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John DiJoseph

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Chemicals & Drugs

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Marc Damelin; Veronica Diesl; John F DiJoseph; Maureen Dougher; Deborah Evans; Maximillian T Follettie; Kenneth G Geles; Jonathon Golas; Janet Gruzas; Philip R Hamann; Shuguang Huang; Maha Karnoub; Kiran Khandke; Arthur Kunz; Kimberly Marquette; Carol Rios; Latha Sridharan; Lioudmila Tchistiakova; Ignacio I Wistuba; Ping Yuan; Robert T Abraham; Douglas Armellino; Michelle Baxter; Carmen Behrens; Erwin R Boghaert; Sung E Choe; Bin-Bing S Zhou
Delineation of a cellular hierarchy in lung cancer reveals an oncofetal antigen expressed on tumor-initiating cells.
John F DiJoseph; Maureen M Dougher; Deborah Y Evans; Bin-Bing Zhou; Nitin K Damle
Preclinical anti-tumor activity of antibody-targeted chemotherapy with CMC-544 (inotuzumab ozogamicin), a CD22-specific immunoconjugate of calicheamicin, compared with non-targeted combination chemotherapy with CVP or CHOP.
Erwin R Boghaert; Kiran M Khandke; Latha Sridharan; Maureen Dougher; John F DiJoseph; Arthur Kunz; Philip R Hamann; Justin Moran; Inder Chaudhary; Nitin Damle
Determination of pharmacokinetic values of calicheamicin-antibody conjugates in mice by plasmon resonance analysis of small (5 microl) blood samples.

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All Publications

2011: Marc Damelin; Veronica Diesl; John F DiJoseph; Maureen Dougher; Deborah Evans; Maximillian T Follettie; Kenneth G Geles; Jonathon Golas; Janet Gruzas; Philip R Hamann; Shuguang Huang; Maha Karnoub; Kiran Khandke; Arthur Kunz; Kimberly Marquette; Carol Rios; Latha Sridharan; Lioudmila Tchistiakova; Ignacio I Wistuba; Ping Yuan; Robert T Abraham; Douglas Armellino; Michelle Baxter; Carmen Behrens; Erwin R Boghaert; Sung E Choe; Bin-Bing S Zhou
Delineation of a cellular hierarchy in lung cancer reveals an oncofetal antigen expressed on tumor-initiating cells.
Cancer research 2011;71(12):4236-46.
2011: John F DiJoseph; Maureen M Dougher; Deborah Y Evans; Bin-Bing Zhou; Nitin K Damle
Preclinical anti-tumor activity of antibody-targeted chemotherapy with CMC-544 (inotuzumab ozogamicin), a CD22-specific immunoconjugate of calicheamicin, compared with non-targeted combination chemotherapy with CVP or CHOP.
Cancer chemotherapy and pharmacology 2011;67(4):741-9.
2008: Erwin R Boghaert; Kiran M Khandke; Latha Sridharan; Maureen Dougher; John F DiJoseph; Arthur Kunz; Philip R Hamann; Justin Moran; Inder Chaudhary; Nitin Damle
Determination of pharmacokinetic values of calicheamicin-antibody conjugates in mice by plasmon resonance analysis of small (5 microl) blood samples.
Cancer chemotherapy and pharmacology 2008;61(6):1027-35.
2008: Erwin R Boghaert; Latha Sridharan; Kiran Khandke; Douglas C Armellino; Matthew G Ryan; K Myers; Richard Harrop; Arthur Kunz; Philip R Hamann; K Marquette; Maureen M Dougher; John F DiJoseph; Nitin K Damle
The oncofetal protein, 5T4, is a suitable target for antibody-guided anti-cancer chemotherapy with calicheamicin.
International journal of oncology 2008;32(1):221-34.
2007: John F DiJoseph; Maureen M Dougher; Douglas C Armellino; D Y Evans; Nitin K Damle
Therapeutic potential of CD22-specific antibody-targeted chemotherapy using inotuzumab ozogamicin (CMC-544) for the treatment of acute lymphoblastic leukemia.
Leukemia 2007;21(11):2240-5.
2007: John F DiJoseph; Maureen M Dougher; Douglas C Armellino; Lyka B Kalyandrug; Arthur Kunz; Erwin R Boghaert; Philip R Hamann; Nitin K Damle
CD20-specific antibody-targeted chemotherapy of non-Hodgkin's B-cell lymphoma using calicheamicin-conjugated rituximab.
Cancer immunology, immunotherapy : CII 2007;56(7):1107-17.
2006: Erwin R Boghaert; Kiran Khandke; Latha Sridharan; Douglas C Armellino; Maureen M Dougher; John F DiJoseph; Arthur Kunz; Philip R Hamann; Ashwin Sridharan; Stanley Jones; Carolyn Discafani; Nitin K Damle
Tumoricidal effect of calicheamicin immuno-conjugates using a passive targeting strategy.
International journal of oncology 2006;28(3):675-84.
2006: John F DiJoseph; Maureen M Dougher; Lyka B Kalyandrug; Douglas C Armellino; Erwin R Boghaert; Philip R Hamann; Justin K Moran; Nitin K Damle
Antitumor efficacy of a combination of CMC-544 (inotuzumab ozogamicin), a CD22-targeted cytotoxic immunoconjugate of calicheamicin, and rituximab against non-Hodgkin's B-cell lymphoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(1):242-9.
2005: John F DiJoseph; Andrew G Popplewell; Simon Tickle; Heather Ladyman; Alastair Lawson; Arthur Kunz; Kiran Khandke; Douglas C Armellino; Erwin R Boghaert; Philip R Hamann; Karen Zinkewich-Peotti; Sue Stephens; Neil Weir; Nitin K Damle
Antibody-targeted chemotherapy of B-cell lymphoma using calicheamicin conjugated to murine or humanized antibody against CD22.
Cancer immunology, immunotherapy : CII 2005;54(1):11-24.
2004: John F DiJoseph; Mary E Goad; Maureen M Dougher; Erwin R Boghaert; Arthur Kunz; Philip R Hamann; Nitin K Damle
Potent and specific antitumor efficacy of CMC-544, a CD22-targeted immunoconjugate of calicheamicin, against systemically disseminated B-cell lymphoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(24):8620-9.
2004: Aranapakam M Venkatesan; Jamie M Davis; George T Grosu; Jannie Baker; Arie Zask; Jeremy I Levin; John W Ellingboe; Jerauld S Skotnicki; John F DiJoseph; Amy Sung; Guixian Jin; Weixin Xu; Diane Joseph McCarthy; Dauphine Barone
Synthesis and structure-activity relationships of 4-alkynyloxy phenyl sulfanyl, sulfinyl, and sulfonyl alkyl hydroxamates as tumor necrosis factor-alpha converting enzyme and matrix metalloproteinase inhibitors.
Journal of medicinal chemistry 2004;47(25):6255-69.
2004: Erwin R Boghaert; Latha Sridharan; Douglas C Armellino; Kiran Khandke; John F DiJoseph; Arthur Kunz; Maureen M Dougher; Fan Jiang; Lyka B Kalyandrug; Philip R Hamann; Philip Frost; Nitin K Damle
Antibody-targeted chemotherapy with the calicheamicin conjugate hu3S193-N-acetyl gamma calicheamicin dimethyl hydrazide targets Lewisy and eliminates Lewisy-positive human carcinoma cells and xenografts.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(13):4538-49.
2004: John F DiJoseph; Douglas C Armellino; Erwin R Boghaert; Kiran Khandke; Maureen M Dougher; Latha Sridharan; Arthur Kunz; Philip R Hamann; boris gorovits; Chandrasekhar Udata; Justin K Moran; Andrew G Popplewell; Sue Stephens; Philip Frost; Nitin K Damle
Antibody-targeted chemotherapy with CMC-544: a CD22-targeted immunoconjugate of calicheamicin for the treatment of B-lymphoid malignancies.
Blood 2004;103(5):1807-14.
2003: Venkatesan Aranapakam; Jamie M Davis; George T Grosu; Jannie Baker; John W Ellingboe; Arie Zask; Jeremy I Levin; Vincent P Sandanayaka; Mila Du; Jerauld S Skotnicki; John F DiJoseph; Amy Sung; Michele A Sharr; Loran M Killar; Thomas Walter; Guixian Jin; Rebecca Cowling; Jeff Tillett; Weiguang Zhao; Joseph McDevitt; Zhang B Xu
Synthesis and structure-activity relationship of N-substituted 4-arylsulfonylpiperidine-4-hydroxamic acids as novel, orally active matrix metalloproteinase inhibitors for the treatment of osteoarthritis.
Journal of medicinal chemistry 2003;46(12):2376-96.
2003: Venkatesan Aranapakam; George T Grosu; Jamie M Davis; Baihua Hu; John W Ellingboe; Jannie L Baker; Jerauld S Skotnicki; Arie Zask; John F DiJoseph; Amy Sung; Michele A Sharr; Loran M Killar; Thomas Walter; Guixian Jin; Rebecca Cowling
Synthesis and structure-activity relationship of alpha-sulfonylhydroxamic acids as novel, orally active matrix metalloproteinase inhibitors for the treatment of osteoarthritis.
Journal of medicinal chemistry 2003;46(12):2361-75.
2003: Arie Zask; Y Gu; J Donald Albright; Xumei Du; M Hogan; Jeremy I Levin; James M Chen; Loran M Killar; Amy Sung; John F DiJoseph; Michele A Sharr; Catherine E Roth; S Skala; Guixian Jin; Rebecca Cowling; Ken Mohler; Dauphine Barone; Roy Black; CJ March; Jerauld S Skotnicki
Synthesis and SAR of bicyclic heteroaryl hydroxamic acid MMP and TACE inhibitors.
Bioorganic & medicinal chemistry letters 2003;13(8):1487-90.
2002: Frances C Nelson; Efren Delos Santos; Jeremy I Levin; James M Chen; Jerauld S Skotnicki; John F DiJoseph; Michele A Sharr; Amy Sung; Loran M Killar; Rebecca Cowling; Guixian Jin; Catherine E Roth; J Donald Albright
Benzodiazepine inhibitors of the MMPs and TACE.
Bioorganic & medicinal chemistry letters 2002;12(20):2867-70.
2001: Jeremy I Levin; James M Chen; Mila T Du; Frances C Nelson; T Wehr; John F DiJoseph; Loran M Killar; S Skala; Amy Sung; Michele A Sharr; Catherine E Roth; Guixian Jin; Rebecca Cowling; L Di; M Sherman; Zhang B Xu; CJ March; Ken Mohler; Roy A Black; Jerauld S Skotnicki
The discovery of anthranilic acid-based MMP inhibitors. Part 3: incorporation of basic amines.
Bioorganic & medicinal chemistry letters 2001;11(22):2975-8.
2001: Jeremy I Levin; J Chen; Mila Du; M Hogan; S Kincaid; Frances C Nelson; Aranapakam M Venkatesan; T Wehr; Arie Zask; John F DiJoseph; Loran M Killar; S Skala; Amy Sung; Michele A Sharr; C Roth; Guixian Jin; Rebecca Cowling; Ken Mohler; Roy A Black; CJ March; Jerauld S Skotnicki
The discovery of anthranilic acid-based MMP inhibitors. Part 2: SAR of the 5-position and P1(1) groups.
Bioorganic & medicinal chemistry letters 2001;11(16):2189-92.
2001: Jeremy I Levin; Y Gu; Frances C Nelson; Arie Zask; John F DiJoseph; Michele A Sharr; Amy Sung; Guixian Jin; Rebecca Cowling; Pranab K Chanda; Scott Cosmi; C L Hsiao; Wade Edris; James Wilhelm; Loran M Killar; Jerauld S Skotnicki
Heteroaryl and cycloalkyl sulfonamide hydroxamic acid inhibitors of matrix metalloproteinases.
Bioorganic & medicinal chemistry letters 2001;11(2):239-42.
2001: Jeremy I Levin; Mila T Du; John F DiJoseph; Loran M Killar; Amy Sung; Thomas Walter; Michele A Sharr; Catherine E Roth; Franklin J Moy; Robert Powers; Guixian Jin; Rebecca Cowling; Jerauld S Skotnicki
The discovery of anthranilic acid-based MMP inhibitors. Part 1: SAR of the 3-position.
Bioorganic & medicinal chemistry letters 2001;11(2):235-8.
1998: Jeremy I Levin; John F DiJoseph; Loran M Killar; Amy Sung; Thomas Walter; Michele A Sharr; Catherine E Roth; Jerauld S Skotnicki; J Donald Albright
The synthesis and biological activity of a novel series of diazepine MMP inhibitors.
Bioorganic & medicinal chemistry letters 1998;8(19):2657-62.
1998: Jeremy I Levin; John F DiJoseph; Loran M Killar; Michele A Sharr; Jerauld S Skotnicki; Dinesh V Patel; Xiao-Yi Xiao; L Shi; M Navre; DA Campbell
The asymmetric synthesis and in vitro characterization of succinyl mercaptoalcohol and mercaptoketone inhibitors of matrix metalloproteinases.
Bioorganic & medicinal chemistry letters 1998;8(10):1163-8.
1998: DA Campbell; Xiao-Yi Xiao; D Harris; S Ida; R Mortezaei; K Ngu; L Shi; D Tien; Y Wang; M Navre; Dinesh V Patel; Michele A Sharr; John F DiJoseph; Loran M Killar; C L Leone; Jeremy I Levin; Jerauld S Skotnicki
Malonyl alpha-mercaptoketones and alpha-mercaptoalcohols, a new class of matrix metalloproteinase inhibitors.
Bioorganic & medicinal chemistry letters 1998;8(10):1157-62.
1996: John F DiJoseph; E Fluhler; J Armstrong; Michele A Sharr; S N Sehgal
Therapeutic blood levels of sirolimus (rapamycin) in the allografted rat.
Transplantation 1996;62(8):1109-12.
1994: John F DiJoseph; M J Mihatsch; S N Sehgal
Renal effects of rapamycin in the spontaneously hypertensive rat.
Transplant international : official journal of the European Society for Organ Transplantation 1994;7(2):83-8.
1993: John F DiJoseph; T L Walter; D A Hartman; R P Carlson
Kidney dysfunction in the arthritic rat.
International journal of immunopharmacology 1993;15(8):933-41.
1993: John F DiJoseph; M J Mihatsch; S N Sehgal
Influence of rat strain on rapamycin's kidney effects.
Transplantation proceedings 1993;25(1 Pt 1):714-5.
1991: R G Caccese; John F DiJoseph; Jerauld S Skotnicki; L E Borella; Laurel M Adams
Inhibition of interleukin-1 (IL-1) induced neutral proteases from rabbit articular chondrocytes by WY-46,135 and WY-48,989.
Agents and actions 1991;34(1-2):223-5.
1991: L Borella; C P Eng; John F DiJoseph; C Wells; J Ward; R Caccese; W L Baeder
Rapid induction of early osteoarthritic-like lesions in the rabbit knee by continuous intra-articular infusion of mammalian collagenase or interleukin-1.
Agents and actions 1991;34(1-2):220-2.
1990: John F DiJoseph; L E Borella; C L Wells; G N Mir
Mucosal protective activity of activated aluminum complex.
Digestion 1990;45(1):19-25.
1990: W A Kinney; N E Lee; R M Blank; C A Demerson; C S Sarnella; N T Scherer; G N Mir; L E Borella; John F DiJoseph; C Wells
N-phenyl-2-pyridinecarbothioamides as gastric mucosal protectants.
Journal of medicinal chemistry 1990;33(1):327-36.
1989: L E Borella; John F DiJoseph; G N Mir
Cytoprotective and antiulcer activities of the antacid magaldrate in the rat.
Arzneimittel-Forschung 1989;39(7):786-9.
1989: John F DiJoseph; C L Wells
Effect of epidermal growth factor on non-steroidal anti-inflammatory drug-induced intestinal damage.
Agents and actions 1989;27(3-4):294-6.
1989: L E Borella; John F DiJoseph
Gastric antisecretory and antiulcer/cytoprotective effects of 2-cyano-3-(ethylthio-3-methylthio)-2-propenoic acid methyl ester.
Arzneimittel-Forschung 1989;39(5):598-601.
1989: John F DiJoseph; L E Borella; G N Mir
Activated aluminum complex derived from solubilized antacids exhibits enhanced cytoprotective activity in the rat.
Gastroenterology 1989;96(3):730-5.
1987: John F DiJoseph; G N Mir
Hyperglycemic effect of lidamidine in the rat.
Archives internationales de pharmacodynamie et de thérapie 1987;288(2):300-8.
1987: John F DiJoseph; J R Eash; G N Mir
Gastric antisecretory and antiulcer effects of WHR1582A, a compound exerting alpha-2 adrenoceptor agonist activity.
The Journal of pharmacology and experimental therapeutics 1987;241(1):97-102.
1984: John F DiJoseph; J A Taylor; G N Mir
Alpha-2 receptors in the gastrointestinal system: a new therapeutic approach.
Life sciences 1984;35(10):1031-42.