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Dimiter Dimitrov

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Weizao Chen; Tianlei Ying; Dimiter S Dimitrov
Antibody-based candidate therapeutics against HIV-1: implications for virus eradication and vaccine design.
Zhongyu Zhu; Christopher C Broder; Weizao Chen; Rui Gong; Prabakaran Ponraj; Dimiter S Dimitrov
Human monoclonal antibodies as candidate therapeutics against emerging viruses and HIV-1.
Zhewei Tang; Brad St Croix; Yen Phung; Min Qian; Amit Chaudhary; Weizao Chen; Dimiter S Dimitrov; Mingqian Feng; Wei Gao; Mitchell Ho
A human single-domain antibody elicits potent antitumor activity by targeting an epitope in mesothelin close to the cancer cell surface.

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All Publications

2013: Weizao Chen; Tianlei Ying; Dimiter S Dimitrov
Antibody-based candidate therapeutics against HIV-1: implications for virus eradication and vaccine design.
Expert opinion on biological therapy 2013;13(5):657-71.
2013: Zhongyu Zhu; Christopher C Broder; Weizao Chen; Rui Gong; Prabakaran Ponraj; Dimiter S Dimitrov
Human monoclonal antibodies as candidate therapeutics against emerging viruses and HIV-1.
Virologica Sinica 2013;28(2):71-80.
2013: Zhewei Tang; Brad St Croix; Yen Phung; Min Qian; Amit Chaudhary; Weizao Chen; Dimiter S Dimitrov; Mingqian Feng; Wei Gao; Mitchell Ho
A human single-domain antibody elicits potent antitumor activity by targeting an epitope in mesothelin close to the cancer cell surface.
Molecular cancer therapeutics 2013;12(4):416-26.
2013: Mingqian Feng; William Douglas Figg; Wei Gao; Weizao Chen; Dimiter S Dimitrov; Yan-Gao Man; Ruoqi Wang; Xin Wei Wang; Mitchell Ho
Therapeutically targeting glypican-3 via a conformation-specific single-domain antibody in hepatocellular carcinoma.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(12):E1083-91.
2013: Waleed Haso; Daniel W Lee; CRYSTAL MACKALL; Richard A Morgan; Ira H Pastan; Nirali N Shah; Maryalice Stetler-Stevenson; ALAN WAYNE; Constance M Yuan; David M Barrett; Dimiter S Dimitrov; David J FitzGerald; Rimas J Orentas
Anti-CD22-chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia.
Blood 2013;121(7):1165-74.
2013: Joel R Meyerson; Erin E H Tran; Theo Verrips; Weizao Chen; Dimiter S Dimitrov; Andrea Gorlani; Oleg Kuybeda; Jeffrey D Lifson; Sriram Subramaniam
Molecular structures of trimeric HIV-1 Env in complex with small antibody derivatives.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(2):513-8.
2013: Aimee J Varewijck; Adriana M Waaijers; Steven W J Lamberts; Piet Uitterlinden; Michael P Brugts; Dimiter S Dimitrov; Yang Feng; Jan Frystyk; Jeannette A Goudzwaard; Leo J Hofland; Joseph A M J L Janssen
Circulating insulin-like growth factors may contribute substantially to insulin receptor isoform A and insulin receptor isoform B signalling.
Molecular and cellular endocrinology 2013;365(1):17-24.
2012: Weizao Chen; Yang Feng; Prabakaran Ponraj; Emily D Streaker; Zhongyu Zhu; Dimiter S Dimitrov
Characterization of human IgG repertoires in an acute HIV-1 infection.
Experimental and molecular pathology 2012;93(3):399-407.
2012: Weizao Chen; Yang Feng; Yanping Wang; Zhongyu Zhu; Dimiter S Dimitrov
Fusion proteins of HIV-1 envelope glycoprotein gp120 with CD4-induced antibodies showed enhanced binding to CD4 and CD4 binding site antibodies.
Biochemical and biophysical research communications 2012;425(4):931-7.
2012: Kurt Gehlsen; Rui Gong; Shaun Kirkpatrick; Yangping Wang; David Wiersma; Dave Bramhill; Yang Feng; Dimiter S Dimitrov
Pharmacokinetics of engineered human monomeric and dimeric CH2 domains.
mAbs 2012;4(4):466-74.
2012: Weizao Chen; Yang Feng; Qi Zhao; Zhongyu Zhu; Dimiter S Dimitrov
Human monoclonal antibodies targeting nonoverlapping epitopes on insulin-like growth factor II as a novel type of candidate cancer therapeutics.
Molecular cancer therapeutics 2012;11(7):1400-10.
2012: Mark J Adler; Dimiter S Dimitrov
Therapeutic antibodies against cancer.
Hematology/oncology clinics of North America 2012;26(3):447-81, vii.
2012: Tianlei Ying; Weizao Chen; Yang Feng; Rui Gong; Dimiter S Dimitrov
Soluble monomeric IgG1 Fc.
The Journal of biological chemistry 2012;287(23):19399-408.
2012: Rui Gong; Weizao Chen; Dimiter S Dimitrov
Candidate antibody-based therapeutics against HIV-1.
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 2012;26(3):143-62.
2012: Prabakaran Ponraj; Maria G Singarayan; Claudia C Stewart; Emily D Streaker; Weizao Chen; Yang Feng; Dimiter S Dimitrov
Expressed antibody repertoires in human cord blood cells: 454 sequencing and IMGT/HighV-QUEST analysis of germline gene usage, junctional diversity, and somatic mutations.
Immunogenetics 2012;64(5):337-50.
2012: Weizao Chen; Dimiter S Dimitrov
Monoclonal antibody-based candidate therapeutics against HIV type 1.
AIDS research and human retroviruses 2012;28(5):425-34.
2012: Weizao Chen; Yang Feng; Prabakaran Ponraj; Daniel E Russ; Emily D Streaker; Dimiter S Dimitrov
Characterization of germline antibody libraries from human umbilical cord blood and selection of monoclonal antibodies to viral envelope glycoproteins: Implications for mechanisms of immune evasion and design of vaccine immunogens.
Biochemical and biophysical research communications 2012;417(4):1164-9.
2012: Mei-Yun Zhang; Javier Guenaga; Jingjing Li; Yuxing Li; Seth H Pincus; Victoria R Polonis; Andrew Rosa Borges; Ruth M Ruprecht; Yanping Wang; Jennifer D Watkins; Richard Wilson; Zheng Yang; Tingting Yuan; Dimiter S Dimitrov
Identification and characterization of a broadly cross-reactive HIV-1 human monoclonal antibody that binds to both gp120 and gp41.
PloS one 2012;7(9):e44241.
2012: Rui Gong; Yanping Wang; Tianlei Ying; Dimiter S Dimitrov
Bispecific engineered antibody domains (nanoantibodies) that interact noncompetitively with an HIV-1 neutralizing epitope and FcRn.
PloS one 2012;7(8):e42288.
2012: Prabakaran Ponraj; Emily D Streaker; Zhongyu Zhu; Weizao Chen; Yang Feng; Rui Gong; Dimiter S Dimitrov
Origin, diversity, and maturation of human antiviral antibodies analyzed by high-throughput sequencing.
Frontiers in microbiology 2012;3():277.
2012: Rui Gong; Weizao Chen; Dimiter S Dimitrov
Expression, purification, and characterization of engineered antibody CH2 and VH domains.
Methods in molecular biology (Clifton, N.J.) 2012;899():85-102.
2012: Qi Zhao; Zhongyu Zhu; Dimiter S Dimitrov
Yeast display of engineered antibody domains.
Methods in molecular biology (Clifton, N.J.) 2012;899():73-84.
2012: Dimiter S Dimitrov
Therapeutic proteins.
Methods in molecular biology (Clifton, N.J.) 2012;899():1-26.
2011: Zhongyu Zhu; Weizao Chen; Genevieve G Fouda; Barton F Haynes; Kristina-Ana Klaric; Peter D Kwong; Hua-Xin Liao; Mark K Louder; John R Mascola; David Montefiori; M Anthony Moody; Gilad Ofek; John Owens; Prabakaran Ponraj; Haiyan Rebekah Qin; Robert Schutte; Jamie K Scott; Xiaoying Shen; Emily Streaker; Georgia D Tomaras; Yanping Wang; Yongping Yang; Qi Zhao; Dimiter S Dimitrov
Cross-reactive HIV-1-neutralizing human monoclonal antibodies identified from a patient with 2F5-like antibodies.
Journal of virology 2011;85(21):11401-8.
2011: Katharine N Bossart; Douglas Brining; Christopher C Broder; Julie Callison; Yee Peng Chan; Antony S Dimitrov; Dimiter S Dimitrov; Friederike Feldmann; Heinz Feldmann; Yan-Ru Feng; Joan B Geisbert; Thomas W Geisbert; Andrew C Hickey; Dana Scott; Yanping Wang; Lianying Yan; Zhongyu Zhu; Barry Rockx
A neutralizing human monoclonal antibody protects african green monkeys from hendra virus challenge.
Science translational medicine 2011;3(105):105ra103.
2011: Tingting Yuan; Yu Zhang; Dimiter S Dimitrov; Jingjing Li; Emily Streaker; Yanping Wang; Mei-Yun Zhang
Putative rhesus macaque germline predecessors of human broadly HIV-neutralizing antibodies: differences from the human counterparts and implications for HIV-1 vaccine development.
Vaccine 2011;29(40):6903-10.
2011: Qi Zhao; Zhongyu Zhu; Yang Feng; Dimiter S Dimitrov
Human monoclonal antibody fragments binding to insulin-like growth factors I and II with picomolar affinity.
Molecular cancer therapeutics 2011;10(9):1677-85.
2011: Weizao Chen; Yang Feng; Rui Gong; Yanping Wang; Qi Zhao; Zhongyu Zhu; Dimiter S Dimitrov
Engineered single human CD4 domains as potent HIV-1 inhibitors and components of vaccine immunogens.
Journal of virology 2011;85(18):9395-405.
2011: Yang Feng; Rui Gong; Dimiter S Dimitrov
Design, expression and characterization of a soluble single-chain functional human neonatal Fc receptor.
Protein expression and purification 2011;79(1):66-71.
2011: Syna Kuriakose Gift; Karyn McFadden; Isaac J Zentner; Srivats Rajagopal; Mei-Yun Zhang; Dimiter S Dimitrov; Irwin Chaiken
Monoclonal antibody m18 paratope leading to dual receptor antagonism of HIV-1 gp120.
Biochemistry 2011;50(14):2769-79.
2011: Syna Kuriakose Gift; Isaac J Zentner; Arne Schön; Karyn McFadden; M Umashankara; Srivats Rajagopal; Mark Contarino; Caitlin Duffy; Joel R Courter; Mei-Yun Zhang; Jonathan M Gershoni; Simon Cocklin; Dimiter S Dimitrov; Amos B Smith; Ernesto Freire; Irwin Chaiken
Conformational and structural features of HIV-1 gp120 underlying the dual receptor antagonism by cross-reactive neutralizing antibody m18.
Biochemistry 2011;50(14):2756-68.
2011: Prabakaran Ponraj; Emily Streaker; Weizao Chen; Dimiter S Dimitrov
454 antibody sequencing - error characterization and correction.
BMC research notes 2011;4():404.
2011: Yang Feng; Michael Lockwood; Philip S Low; Jiayin Shen; Emily D Streaker; Zhongyu Zhu; Dimiter S Dimitrov
A folate receptor beta-specific human monoclonal antibody recognizes activated macrophage of rheumatoid patients and mediates antibody-dependent cell-mediated cytotoxicity.
Arthritis research & therapy 2011;13(2):R59.
2010: Weizao Chen; Xiaodong Xiao; Yanping Wang; Zhongyu Zhu; Dimiter S Dimitrov
Bifunctional fusion proteins of the human engineered antibody domain m36 with human soluble CD4 are potent inhibitors of diverse HIV-1 isolates.
Antiviral research 2010;88(1):107-15.
2010: Yang Feng; Xiaodong Xiao; Zhongyu Zhu; Dimiter S Dimitrov
Identification and characterization of a novel agonistic anti-DR4 human monoclonal antibody.
mAbs 2010;2(5):565-70.
2010: Dimiter S Dimitrov
Therapeutic antibodies, vaccines and antibodyomes.
mAbs 2010;2(3):347-56.
2010: Mei-Yun Zhang; Andrew Rosa Borges; Roger G Ptak; Yanping Wang; Antony S Dimitrov; S Munir Alam; Lindsay Wieczorek; Peter Bouma; Timothy Fouts; Shibo Jiang; Victoria R Polonis; Barton F Haynes; Gerald V Quinnan; David C Montefiori; Dimiter S Dimitrov
Potent and broad neutralizing activity of a single chain antibody fragment against cell-free and cell-associated HIV-1.
mAbs 2010;2(3):266-74.
2010: Kristin Loomis; Brandon Smith; Yang Feng; Himanshu Garg; Amichai Yavlovich; Ryan Campbell-Massa; Dimiter S Dimitrov; Robert Blumenthal; Xiaodong Xiao; Anu Puri
Specific targeting to B cells by lipid-based nanoparticles conjugated with a novel CD22-ScFv.
Experimental and molecular pathology 2010;88(2):238-49.
2010: Xiaodong Xiao; Zhongyu Zhu; Jennifer L Dankmeyer; Michael M Wormald; Randy L Fast; Patricia L Worsham; Christopher K Cote; Kei Amemiya; Dimiter S Dimitrov
Human anti-plague monoclonal antibodies protect mice from Yersinia pestis in a bubonic plague model.
PloS one 2010;5(10):e13047.
2010: Taichi Kimura; Takeshi Kuwata; Satoshi Ashimine; Manabu Yamazaki; Chisako Yamauchi; Kanji Nagai; Akashi Ikehara; Yang Feng; Dimiter S Dimitrov; Seiichi Saito; Atsushi Ochiai
Targeting of bone-derived insulin-like growth factor-II by a human neutralizing antibody suppresses the growth of prostate cancer cells in a human bone environment.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(1):121-9.
2010: Weizao Chen; Zhongyu Zhu; Yang Feng; Dimiter S Dimitrov
A large human domain antibody library combining heavy and light chain CDR3 diversity.
Molecular immunology 2010;47(4):912-21.
2009: Xiaodong Xiao; Weizao Chen; Yang Feng; Zhongyu Zhu; Prabakaran Ponraj; Yanping Wang; Mei-Yun Zhang; Nancy S Longo; Dimiter S Dimitrov
Germline-like predecessors of broadly neutralizing antibodies lack measurable binding to HIV-1 envelope glycoproteins: implications for evasion of immune responses and design of vaccine immunogens.
Biochemical and biophysical research communications 2009;390(3):404-9.
2009: Xiaodong Xiao; Yang Feng; Weizao Chen; Dimiter S Dimitrov
Maturation Pathways of Cross-Reactive HIV-1 Neutralizing Antibodies.
Viruses 2009;1(3):802-17.
2009: Lei Chen; Young Do Kwon; Tongqing Zhou; Xueling Wu; Sijy O'Dell; Lisa Cavacini; Ann J Hessell; Marie Pancera; Min Tang; Ling Xu; Zhi-Yong Yang; Mei-Yun Zhang; James Arthos; Dennis R Burton; Dimiter S Dimitrov; Gary Nabel; Marshall R Posner; Joseph Sodroski; Richard Wyatt; John R Mascola; Peter D Kwong
Structural basis of immune evasion at the site of CD4 attachment on HIV-1 gp120.
Science (New York, N.Y.) 2009;326(5956):1123-7.
2009: Katharine N Bossart; Zhongyu Zhu; Deborah Middleton; Jessica Klippel; Gary Crameri; John Bingham; Jennifer McEachern; Diane Green; Timothy J Hancock; Yee Peng Chan; Andrew C Hickey; Dimiter S Dimitrov; Lin-Fa Wang; Christopher C Broder
A neutralizing human monoclonal antibody protects against lethal disease in a new ferret model of acute nipah virus infection.
PLoS pathogens 2009;5(10):e1000642.
2009: Xiaodong Xiao; Yang Feng; Bang K Vu; Rieko Ishima; Dimiter S Dimitrov
A large library based on a novel (CH2) scaffold: identification of HIV-1 inhibitors.
Biochemical and biophysical research communications 2009;387(2):387-92.
2009: Mei-Yun Zhang; Yang Feng; Yanping Wang; Dimiter S Dimitrov
Characterization of a chimeric monoclonal antibody against the insulin-like growth factor-I receptor.
mAbs 2009;1(5):475-80.
2009: Boopathy Ramakrishnan; Elizabeth Boeggeman; Maria Manzoni; Zhongyu Zhu; Kristin Loomis; Anu Puri; Dimiter S Dimitrov; Pradman K Qasba
Multiple site-specific in vitro labeling of single-chain antibody.
Bioconjugate chemistry 2009;20(7):1383-9.
2009: Rui Gong; Bang K Vu; Yang Feng; DaRue A Prieto; Marzena A Dyba; Joseph D Walsh; Prabakaran Ponraj; Timothy D Veenstra; Sergey G Tarasov; Rieko Ishima; Dimiter S Dimitrov
Engineered human antibody constant domains with increased stability.
The Journal of biological chemistry 2009;284(21):14203-10.
2009: Xiaodong Xiao; Mitchell Ho; Zhongyu Zhu; Ira Pastan; Dimiter S Dimitrov
Identification and characterization of fully human anti-CD22 monoclonal antibodies.
mAbs 2009;1(3):297-303.
2009: Yang Feng; Xiaodong Xiao; Zhongyu Zhu; Emily Streaker; Mitchell Ho; Ira Pastan; Dimiter S Dimitrov
A novel human monoclonal antibody that binds with high affinity to mesothelin-expressing cells and kills them by antibody-dependent cell-mediated cytotoxicity.
Molecular cancer therapeutics 2009;8(5):1113-8.
2009: Weizao Chen; Dimiter S Dimitrov
Human monoclonal antibodies and engineered antibody domains as HIV-1 entry inhibitors.
Current opinion in HIV and AIDS 2009;4(2):112-7.
2009: Prabakaran Ponraj; Zhongyu Zhu; Xiaodong Xiao; Arya Biragyn; Antony S Dimitrov; Christopher C Broder; Dimiter S Dimitrov
Potent human monoclonal antibodies against SARS CoV, Nipah and Hendra viruses.
Expert opinion on biological therapy 2009;9(3):355-68.
2009: Mei-Yun Zhang; Yanping Wang; Marie K Mankowski; Roger G Ptak; Dimiter S Dimitrov
Cross-reactive HIV-1-neutralizing activity of serum IgG from a rabbit immunized with gp41 fused to IgG1 Fc: possible role of the prolonged half-life of the immunogen.
Vaccine 2009;27(6):857-63.
2009: Dimiter S Dimitrov
Engineered CH2 domains (nanoantibodies).
mAbs 2009;1(1):26-8.
2009: Mei-Yun Zhang; Dimiter S Dimitrov
Sequential antigen panning for selection of broadly cross-reactive HIV-1-neutralizing human monoclonal antibodies.
Methods in molecular biology (Clifton, N.J.) 2009;562():143-54.
2009: Dimiter S Dimitrov; James D Marks
Therapeutic antibodies: current state and future trends--is a paradigm change coming soon?
Methods in molecular biology (Clifton, N.J.) 2009;525():1-27, xiii.
2009: Yang Feng; Dimiter S Dimitrov
Scaling-up and production of therapeutic antibodies for preclinical studies.
Methods in molecular biology (Clifton, N.J.) 2009;525():499-508, xiii.
2009: Bang K Vu; Joseph D Walsh; Dimiter S Dimitrov; Rieko Ishima
Dynamics of antibody domains studied by solution NMR.
Methods in molecular biology (Clifton, N.J.) 2009;525():533-43, xv.
2009: Weizao Chen; Zhongyu Zhu; Xiaodong Xiao; Dimiter S Dimitrov
Construction of a human antibody domain (VH) library.
Methods in molecular biology (Clifton, N.J.) 2009;525():81-99, xiii.
2009: Zhongyu Zhu; Dimiter S Dimitrov
Construction of a large naïve human phage-displayed Fab library through one-step cloning.
Methods in molecular biology (Clifton, N.J.) 2009;525():129-42, xv.
2009: Mei-Yun Zhang; Dimiter S Dimitrov
Competitive antigen panning for selection of HIV-1 neutralizing human monoclonal antibodies specific for gp41.
Methods in molecular biology (Clifton, N.J.) 2009;525():175-86, xv.
2008: Weizao Chen; Zhongyu Zhu; Yang Feng; Dimiter S Dimitrov
Human domain antibodies to conserved sterically restricted regions on gp120 as exceptionally potent cross-reactive HIV-1 neutralizers.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(44):17121-6.
2008: Kimberly A Bishop; Andrew C Hickey; Dimple Khetawat; Jared R Patch; Katharine N Bossart; Zhongyu Zhu; Lin-Fa Wang; Dimiter S Dimitrov; Christopher C Broder
Residues in the stalk domain of the hendra virus g glycoprotein modulate conformational changes associated with receptor binding.
Journal of virology 2008;82(22):11398-409.
2008: Weizao Chen; Zhongyu Zhu; Yang Feng; Xiaodong Xiao; Dimiter S Dimitrov
Construction of a large phage-displayed human antibody domain library with a scaffold based on a newly identified highly soluble, stable heavy chain variable domain.
Journal of molecular biology 2008;382(3):779-89.
2008: Prabakaran Ponraj; Bang K Vu; Jianhua Gan; Yang Feng; Dimiter S Dimitrov; Xinhua Ji
Structure of an isolated unglycosylated antibody C(H)2 domain.
Acta crystallographica. Section D, Biological crystallography 2008;64(Pt 10):1062-7.
2008: Mei-Yun Zhang; Bang K Vu; Anil Choudhary; Hong Lu; Michael Humbert; Helena Ong; Munir Alam; Ruth Ruprecht; Gerald Quinnan; Shibo Jiang; David C Montefiori; John R Mascola; Christopher C Broder; Barton F Haynes; Dimiter S Dimitrov
Cross-reactive human immunodeficiency virus type 1-neutralizing human monoclonal antibody that recognizes a novel conformational epitope on gp41 and lacks reactivity against self-antigens.
Journal of virology 2008;82(14):6869-79.
2008: Victoria R Polonis; Bruce K Brown; Andrew Rosa Borges; Susan Zolla-Pazner; Dimiter S Dimitrov; Mei-Yun Zhang; Susan W Barnett; Ruth Ruprecht; Gabriella Scarlatti; Eva Maria Fenyö; David C Montefiori; Francine E McCutchan; Nelson L Michael
Recent advances in the characterization of HIV-1 neutralization assays for standardized evaluation of the antibody response to infection and vaccination.
Virology 2008;375(2):315-20.
2008: Zhongyu Zhu; Katharine N Bossart; Kimberly A Bishop; Gary Crameri; Antony S Dimitrov; Jennifer A McEachern; Yang Feng; Deborah Middleton; Lin-Fa Wang; Christopher C Broder; Dimiter S Dimitrov
Exceptionally potent cross-reactive neutralization of Nipah and Hendra viruses by a human monoclonal antibody.
The Journal of infectious diseases 2008;197(6):846-53.
2008: Katharine N Bossart; Mary Tachedjian; Jennifer McEachern; Gary Crameri; Zhongyu Zhu; Dimiter S Dimitrov; Christopher C Broder; Lin-Fa Wang
Functional studies of host-specific ephrin-B ligands as Henipavirus receptors.
Virology 2008;372(2):357-71.
2008: Yang Feng; Dimiter S Dimitrov
Monoclonal antibodies against components of the IGF system for cancer treatment.
Current opinion in drug discovery & development 2008;11(2):178-85.
2008: Yanina Rozenberg-Adler; John Conner; Hector Aguilar-Carreno; Samitabh Chakraborti; Dimiter S Dimitrov; W French Anderson
Membrane-proximal cytoplasmic domain of Moloney murine leukemia virus envelope tail facilitates fusion.
Experimental and molecular pathology 2008;84(1):18-30.
2008: Raquel F Epand; Yan-Liang Zhang; Tajib Mirzabekov; Bruce L Kagan; Anatoly Silberstein; Wayne L Hubbell; Richard M Epand; Samitabh Chakraborti; Dimiter S Dimitrov; W French Anderson; Yanina Rozenberg-Adler
Membrane activity of an amphiphilic alpha-helical membrane-proximal cytoplasmic domain of the MoMuLV envelope glycoprotein.
Experimental and molecular pathology 2008;84(1):9-17.
2007: Xiaodong Xiao; Dimiter S Dimitrov
Monoclonal antibodies against viruses and bacteria: a survey of patents.
Recent patents on anti-infective drug discovery 2007;2(3):171-7.
2007: Li-Rong Yu; Zhongyu Zhu; King C Chan; Haleem J Issaq; Dimiter S Dimitrov; Timothy D Veenstra
Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.
Journal of proteome research 2007;6(11):4150-62.
2007: Dimiter S Dimitrov; Lin-Fa Wang
In utero transmission of Nipah virus: role played by pregnancy and vertical transmission in Henipavirus epidemiology.
The Journal of infectious diseases 2007;196(6):807-9.
2007: Zhongyu Zhu; Samitabh Chakraborti; Yuxian He; Anjeanette Roberts; Timothy Sheahan; Xiaodong Xiao; Lisa E Hensley; Prabakaran Ponraj; Barry Rockx; Igor Sidorov; Davide Corti; Leatrice Vogel; Yang Feng; Jae-Ouk Kim; Lin-Fa Wang; Ralph S Baric; Antonio Lanzavecchia; Kris Curtis; Gary Nabel; Kanta Subbarao; Shibo Jiang; Dimiter S Dimitrov
Potent cross-reactive neutralization of SARS coronavirus isolates by human monoclonal antibodies.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(29):12123-8.
2007: Sonia Jiménez-Baranda; Concepción Gómez-Moutón; Ana Rojas; Lorena Martínez-Prats; Emilia Mira; Rosa Ana Lacalle; Alfonso Valencia; Dimiter S Dimitrov; Antonella Viola; Rafael Delgado; Carlos Martínez-A; Santos Mañes
Filamin-A regulates actin-dependent clustering of HIV receptors.
Nature cell biology 2007;9(7):838-46.
2007: Vidita Choudhry; Mei-Yun Zhang; Igor A Sidorov; John M Louis; Ilia Harris; Antony S Dimitrov; Peter Bouma; Fatim Cham; Anil Choudhary; Susanna M Rybak; Timothy R Fouts; David C Montefiori; Christopher C Broder; Gerald V Quinnan; Dimiter S Dimitrov
Cross-reactive HIV-1 neutralizing monoclonal antibodies selected by screening of an immune human phage library against an envelope glycoprotein (gp140) isolated from a patient (R2) with broadly HIV-1 neutralizing antibodies.
Virology 2007;363(1):79-90.
2007: Katharine N Bossart; Jennifer McEachern; Andrew C Hickey; Vidita Choudhry; Dimiter S Dimitrov; Bryan T Eaton; Lin-Fa Wang
Neutralization assays for differential henipavirus serology using Bio-Plex protein array systems.
Journal of virological methods 2007;142(1-2):29-40.
2007: Robert Blumenthal; Dimiter S Dimitrov
Targeting the sticky fingers of HIV-1.
Cell 2007;129(2):243-5.
2007: Tongqing Zhou; Ling Xu; Barna Dey; Ann J Hessell; Donald Van Ryk; Shi-Hua Xiang; Xinzhen Yang; Mei-Yun Zhang; Michael B Zwick; James Arthos; Dennis R Burton; Dimiter S Dimitrov; Joseph Sodroski; Richard Wyatt; Gary Nabel; Peter D Kwong
Structural definition of a conserved neutralization epitope on HIV-1 gp120.
Nature 2007;445(7129):732-7.
2007: Prabakaran Ponraj; Antony S Dimitrov; Timothy R Fouts; Dimiter S Dimitrov
Structure and function of the HIV envelope glycoprotein as entry mediator, vaccine immunogen, and target for inhibitors.
Advances in pharmacology (San Diego, Calif.) 2007;55():33-97.
2007: Mei-Yun Zhang; Dimiter S Dimitrov
Novel approaches for identification of broadly cross-reactive HIV-1 neutralizing human monoclonal antibodies and improvement of their potency.
Current pharmaceutical design 2007;13(2):203-12.
2006: Mei-Yun Zhang; Vidita Choudhry; Igor A Sidorov; Vladimir Tenev; Bang K Vu; Anil Choudhary; Hong Lu; Gabriela Stiegler; Hermann Katinger; Shibo Jiang; Christopher C Broder; Dimiter S Dimitrov
Selection of a novel gp41-specific HIV-1 neutralizing human antibody by competitive antigen panning.
Journal of immunological methods 2006;317(1-2):21-30.
2006: Yang Feng; Jin Hui Yuan; Sharon C Maloid; Rebecca Fisher; Terry D Copeland; Dan Longo; Thomas P Conrads; Timothy D Veenstra; Andrea Ferris; Steve Hughes; Dimiter S Dimitrov; Douglass K Ferris
Polo-like kinase 1-mediated phosphorylation of the GTP-binding protein Ran is important for bipolar spindle formation.
Biochemical and biophysical research communications 2006;349(1):144-52.
2006: Vidita Choudhry; Mei-Yun Zhang; Ilia Harris; Igor A Sidorov; Bang K Vu; Antony S Dimitrov; Timothy R Fouts; Dimiter S Dimitrov
Increased efficacy of HIV-1 neutralization by antibodies at low CCR5 surface concentration.
Biochemical and biophysical research communications 2006;348(3):1107-15.
2006: Prabakaran Ponraj; Jianhua Gan; Yang Feng; Zhongyu Zhu; Vidita Choudhry; Xiaodong Xiao; Xinhua Ji; Dimiter S Dimitrov
Structure of severe acute respiratory syndrome coronavirus receptor-binding domain complexed with neutralizing antibody.
The Journal of biological chemistry 2006;281(23):15829-36.
2006: Vidita Choudhry; Mei-Yun Zhang; Dimana Dimitrova; Prabakaran Ponraj; Antony S Dimitrov; Timothy R Fouts; Dimiter S Dimitrov
Antibody-based inhibitors of HIV infection.
Expert opinion on biological therapy 2006;6(5):523-31.
2006: Prabakaran Ponraj; Jianhua Gan; You-Qiang Wu; Mei-Yun Zhang; Dimiter S Dimitrov; Xinhua Ji
Structural mimicry of CD4 by a cross-reactive HIV-1 neutralizing antibody with CDR-H2 and H3 containing unique motifs.
Journal of molecular biology 2006;357(1):82-99.
2006: Michele Di Mascio; Irini Sereti; Lynn T Matthews; Ven Natarajan; Joseph W Adelsberger; Richard A Lempicki; Christian Yoder; Elizabeth Jones; Catherine Chow; Julia A Metcalf; Igor A Sidorov; Dimiter S Dimitrov; Michael A Polis; Joseph A Kovacs
Naïve T-cell dynamics in human immunodeficiency virus type 1 infection: effects of highly active antiretroviral therapy provide insights into the mechanisms of naive T-cell depletion.
Journal of virology 2006;80(6):2665-74.
2006: Zhongyu Zhu; Antony S Dimitrov; Samitabh Chakraborti; Dimana Dimitrova; Xiaodong Xiao; Christopher C Broder; Dimiter S Dimitrov
Development of human monoclonal antibodies against diseases caused by emerging and biodefense-related viruses.
Expert review of anti-infective therapy 2006;4(1):57-66.
2006: Geoff Patton; R Stephens; Igor A Sidorov; X Xiao; Richard A Lempicki; Dimiter S Dimitrov; R H Shoemaker; G Tudor
Transcriptomic response to differentiation induction.
BMC bioinformatics 2006;7():81.
2006: Yang Feng; Zhongyu Zhu; Xiaodong Xiao; Vidita Choudhry; J Carl Barrett; Dimiter S Dimitrov
Novel human monoclonal antibodies to insulin-like growth factor (IGF)-II that potently inhibit the IGF receptor type I signal transduction function.
Molecular cancer therapeutics 2006;5(1):114-20.
2006: Zhongyu Zhu; Antony S Dimitrov; Katharine N Bossart; Gary Crameri; Kimberly A Bishop; Vidita Choudhry; Bruce A Mungall; Yan-Ru Feng; Anil Choudhary; Mei-Yun Zhang; Yang Feng; Lin-Fa Wang; Xiaodong Xiao; Bryan T Eaton; Christopher C Broder; Dimiter S Dimitrov
Potent neutralization of Hendra and Nipah viruses by human monoclonal antibodies.
Journal of virology 2006;80(2):891-9.
2005: Chih-chin Huang; Min Tang; Mei-Yun Zhang; Shahzad Majeed; Elizabeth Montabana; Robyn L Stanfield; Dimiter S Dimitrov; Bette Korber; Joseph Sodroski; Ian A Wilson; Richard Wyatt; Peter D Kwong
Structure of a V3-containing HIV-1 gp120 core.
Science (New York, N.Y.) 2005;310(5750):1025-8.
2005: Xiaodong Xiao; Igor A Sidorov; Jennifer Gee; Richard A Lempicki; Dimiter S Dimitrov
Retinoic acid-induced downmodulation of telomerase activity in human cancer cells.
Experimental and molecular pathology 2005;79(2):108-17.
2005: Joseph A Kovacs; Richard A Lempicki; Igor A Sidorov; Joseph W Adelsberger; Irini Sereti; William Sachau; Grace Kelly; Julia A Metcalf; Richard Davey; Judith Falloon; Michael A Polis; Jorge A Tavel; Randy Stevens; Laurie Lambert; Douglas A Hosack; Marjorie Bosche; Haleem J Issaq; Stephen D Fox; Susan F Leitman; Michael Baseler; Henry Masur; Michele Di Mascio; Dimiter S Dimitrov; H Clifford Lane
Induction of prolonged survival of CD4+ T lymphocytes by intermittent IL-2 therapy in HIV-infected patients.
The Journal of clinical investigation 2005;115(8):2139-48.
2005: Matthew I Bonaparte; Antony S Dimitrov; Katharine N Bossart; Gary Crameri; Bruce A Mungall; Kimberly A Bishop; Vidita Choudhry; Dimiter S Dimitrov; Lin-Fa Wang; Bryan T Eaton; Christopher C Broder
Ephrin-B2 ligand is a functional receptor for Hendra virus and Nipah virus.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(30):10652-7.
2005: Mei-Yun Zhang; Vidita Choudhry; Xiaodong Xiao; Dimiter S Dimitrov
Human monoclonal antibodies to the S glycoprotein and related proteins as potential therapeutics for SARS.
Current opinion in molecular therapeutics 2005;7(2):151-6.
2005: Andrew J Sloane; Vic Raso; Dimiter S Dimitrov; Xiaodong Xiao; Shivashni Deo; Nick Muljadi; David Restuccia; Stuart G Turville; Christine Kearney; Christopher C Broder; Hans Zoellner; Anthony L Cunningham; Linda Bendall; Garry W Lynch
Marked structural and functional heterogeneity in CXCR4: separation of HIV-1 and SDF-1alpha responses.
Immunology and cell biology 2005;83(2):129-43.
2005: Samitabh Chakraborti; Prabakaran Ponraj; Xiaodong Xiao; Dimiter S Dimitrov
The SARS coronavirus S glycoprotein receptor binding domain: fine mapping and functional characterization.
Virology journal 2005;2():73.
2004: Matthew Huentelman; Jasenka Zubcevic; José A Hernández Prada; Xiaodong Xiao; Dimiter S Dimitrov; Mohan K Raizada; David A Ostrov
Structure-based discovery of a novel angiotensin-converting enzyme 2 inhibitor.
Hypertension 2004;44(6):903-6.
2004: Xiaodong Xiao; Dimiter S Dimitrov
The SARS-CoV S glycoprotein.
Cellular and molecular life sciences : CMLS 2004;61(19-20):2428-30.
2004: Xiaodong Xiao; Yang Feng; Samitabh Chakraborti; Dimiter S Dimitrov
Oligomerization of the SARS-CoV S glycoprotein: dimerization of the N-terminus and trimerization of the ectodomain.
Biochemical and biophysical research communications 2004;322(1):93-9.
2004: Xiaodong Xiao; Dimiter S Dimitrov
Cell biology of virus entry: a review of the 4th International Frederick Meeting.
Molecular membrane biology 2004;21(5):281-7.
2004: Mei-Yun Zhang; Xiaodong Xiao; Igor A Sidorov; Vidita Choudhry; Fatim Cham; Peng Fei Zhang; Peter Bouma; Michael B Zwick; Anil Choudhary; David C Montefiori; Christopher C Broder; Dennis R Burton; Gerald V Quinnan; Dimiter S Dimitrov
Identification and characterization of a new cross-reactive human immunodeficiency virus type 1-neutralizing human monoclonal antibody.
Journal of virology 2004;78(17):9233-42.
2004: Chih-chin Huang; Miro Venturi; Shahzad Majeed; Michael J Moore; Sanjay Phogat; Mei-Yun Zhang; Dimiter S Dimitrov; Wayne A Hendrickson; James Robinson; Joseph Sodroski; Richard Wyatt; Hyeryun Choe; Michael Farzan; Peter D Kwong
Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):2706-11.
2004: Mei-Yun Zhang; Yuuei Shu; Igor Sidorov; Dimiter S Dimitrov
Identification of a novel CD4i human monoclonal antibody Fab that neutralizes HIV-1 primary isolates from different clades.
Antiviral research 2004;61(3):161-4.
2004: Ramalakshmi Darbha; Sanjay Phogat; Aran F Labrijn; Yuuei Shu; Yijun Gu; Michelle Andrykovitch; Mei-Yun Zhang; Ralph Pantophlet; Loic MARTIN; Claudio Vita; Dennis R Burton; Dimiter S Dimitrov; Xinhua Ji
Crystal structure of the broadly cross-reactive HIV-1-neutralizing Fab X5 and fine mapping of its epitope.
Biochemistry 2004;43(6):1410-7.
2004: Dimiter S Dimitrov
Virus entry: molecular mechanisms and biomedical applications.
Nature reviews. Microbiology 2004;2(2):109-22.
2004: Prabakaran Ponraj; Xiaodong Xiao; Dimiter S Dimitrov
A model of the ACE2 structure and function as a SARS-CoV receptor.
Biochemical and biophysical research communications 2004;314(1):235-41.
2004: Igor Sidorov; Dennis Gee; Dimiter S Dimitrov
A kinetic model of telomere shortening in infants and adults.
Journal of theoretical biology 2004;226(2):169-75.
2004: Mei-Yun Zhang; Yuuei Shu; Donna Rudolph; Prabakaran Ponraj; Aran F Labrijn; Michael B Zwick; Renu B Lal; Dimiter S Dimitrov
Improved breadth and potency of an HIV-1-neutralizing human single-chain antibody by random mutagenesis and sequential antigen panning.
Journal of molecular biology 2004;335(1):209-19.
2003: Xiaodong Xiao; Samitabh Chakraborti; Anthony S Dimitrov; Kosi Gramatikoff; Dimiter S Dimitrov
The SARS-CoV S glycoprotein: expression and functional characterization.
Biochemical and biophysical research communications 2003;312(4):1159-64.
2003: Dimiter S Dimitrov
The secret life of ACE2 as a receptor for the SARS virus.
Cell 2003;115(6):652-3.
2003: Mei-Yun Zhang; Yuuei Shu; Sanjay Phogat; Xiaodong Xiao; Fatim Cham; Peter Bouma; Anil Choudhary; Yan-Ru Feng; Inaki Sanz; Susanna M Rybak; Christopher C Broder; Gerald V Quinnan; Thomas Evans; Dimiter S Dimitrov
Broadly cross-reactive HIV neutralizing human monoclonal antibody Fab selected by sequential antigen panning of a phage display library.
Journal of immunological methods 2003;283(1-2):17-25.
2003: Xiaodong Xiao; Meropi Athanasiou; Igor A Sidorov; Izumi Horikawa; Gina Cremona; Donald Blair; J Carl Barret; Dimiter S Dimitrov
Role of Ets/Id proteins for telomerase regulation in human cancer cells.
Experimental and molecular pathology 2003;75(3):238-47.
2003: Xiaodong Xiao; Sanjay Phogat; Yuuei Shu; Adhuna Phogat; Yen-Hung Chow; Olivia L Wei; Harris Goldstein; Christopher C Broder; Dimiter S Dimitrov
Purified complexes of HIV-1 envelope glycoproteins with CD4 and CCR5(CXCR4): production, characterization and immunogenicity.
Vaccine 2003;21(27-30):4275-84.
2003: Paul K Tan; Thomas J Downey; Edward L Spitznagel; Pin Xu; Dadin Fu; Dimiter S Dimitrov; Richard A Lempicki; Bruce M Raaka; Margaret C Cam
Evaluation of gene expression measurements from commercial microarray platforms.
Nucleic acids research 2003;31(19):5676-84.
2003: Aran F Labrijn; Pascal Poignard; Aarti Raja; Michael B Zwick; Karla Delgado; Michael Franti; James M Binley; Veronique Vivona; Christoph Grundner; Chih-Chin Huang; Miro Venturi; Christos J Petropoulos; Terri Wrin; Dimiter S Dimitrov; James Robinson; Peter D Kwong; Richard Wyatt; Joseph Sodroski; Dennis R Burton
Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gp120 is sterically restricted on primary human immunodeficiency virus type 1.
Journal of virology 2003;77(19):10557-65.
2003: Sanjay Phogat; Dimiter S Dimitrov
Cell biology of virus entry: a review of selected topics from the 3rd International Frederick meeting.
Biochimica et biophysica acta 2003;1614(1):85-8.
2003: Peter Bouma; Maria Leavitt; Peng Fei Zhang; Igor A Sidorov; Dimiter S Dimitrov; Gerald V Quinnan
Multiple interactions across the surface of the gp120 core structure determine the global neutralization resistance phenotype of human immunodeficiency virus type 1.
Journal of virology 2003;77(14):8061-71.
2003: Robert Staudinger; Sanjay Phogat; Xiaodong Xiao; Xiahong Wang; Dimiter S Dimitrov; Susan Zolla-Pazner
Evidence for CD4-enchanced signaling through the chemokine receptor CCR5.
The Journal of biological chemistry 2003;278(12):10389-92.
2003: Igor Sidorov; Ken S Hirsch; Calvin B Harley; Dimiter S Dimitrov
Cancer treatment by telomerase inhibitors: predictions by a kinetic model.
Mathematical biosciences 2003;181(2):209-21.
2003: Maria Leavitt; Eun Ju Park; Igor A Sidorov; Dimiter S Dimitrov; Gerald V Quinnan
Concordant modulation of neutralization resistance and high infectivity of the primary human immunodeficiency virus type 1 MN strain and definition of a potential gp41 binding site in gp120.
Journal of virology 2003;77(1):560-70.
2002: Igor Sidorov; Ken S Hirsch; Calvin B Harley; Dimiter S Dimitrov
Cancer cell dynamics in presence of telomerase inhibitors: analysis of in vitro data.
Journal of theoretical biology 2002;219(2):225-33.
2002: Xiaodong Xiao; Sanjay Phogat; Igor A Sidorov; J Yang; I Horikawa; D Prieto; J Adelesberger; Richard A Lempicki; J C Barrett; Dimiter S Dimitrov
Identification and characterization of rapidly dividing U937 clones with differential telomerase activity and gene expression profiles: role of c-Myc/Mad1 and Id/Ets proteins.
Leukemia 2002;16(9):1877-80.
2002: Arya Biragyn; Igor M Belyakov; Yen-Hung Chow; Dimiter S Dimitrov; Jay A Berzofsky; Larry W Kwak
DNA vaccines encoding human immunodeficiency virus-1 glycoprotein 120 fusions with proinflammatory chemoattractants induce systemic and mucosal immune responses.
Blood 2002;100(4):1153-9.
2002: Anthony D Cristillo; Xiaodong Xiao; Regina Campbell-Malone; Dimiter S Dimitrov; Barbara E Bierer
Differences between CEM and human peripheral blood T lymphocytes in cAMP-dependent HIV viral fusion and CXCR4 expression.
Experimental and molecular pathology 2002;73(1):9-18.
2002: Hana Golding; Marina Zaitseva; Eve de Rosny; Lisa R King; Jody Manischewitz; Igor Sidorov; Miroslaw K Gorny; Susan Zolla-Pazner; Dimiter S Dimitrov; Carol D Weiss
Dissection of human immunodeficiency virus type 1 entry with neutralizing antibodies to gp41 fusion intermediates.
Journal of virology 2002;76(13):6780-90.
2002: Yen-Hung Chow; Olivia L Wei; Sanjay Phogat; Igor A Sidorov; Timothy R Fouts; Christopher C Broder; Dimiter S Dimitrov
Conserved structures exposed in HIV-1 envelope glycoproteins stabilized by flexible linkers as potent entry inhibitors and potential immunogens.
Biochemistry 2002;41(22):7176-82.
2002: Bo Peng; Rebecca Voltan; Lulu Lim; Yvette Edghill Spano; Sanjay Phogat; Dimiter S Dimitrov; Kamalpreet Arora; Michel Leno; Soe Than; ruth woodward; Phillip D Markham; Martin Cranage; Marjorie Robert-Guroff
Rhesus macaque resistance to mucosal simian immunodeficiency virus infection is associated with a postentry block in viral replication.
Journal of virology 2002;76(12):6016-26.
2002: Maxime Moulard; Sanjay Phogat; Yuuei Shu; Aran F Labrijn; Xiaodong Xiao; James M Binley; Mei-Yun Zhang; Igor A Sidorov; Christopher C Broder; James Robinson; Paul W H I Parren; Dennis R Burton; Dimiter S Dimitrov
Broadly cross-reactive HIV-1-neutralizing human monoclonal Fab selected for binding to gp120-CD4-CCR5 complexes.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(10):6913-8.
2002: Anthony D Cristillo; Helene C Highbarger; Robin L Dewar; Dimiter S Dimitrov; Hana Golding; Barbara E Bierer
Up-regulation of HIV coreceptor CXCR4 expression in human T lymphocytes is mediated in part by a cAMP-responsive element.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(3):354-64.
2001: Joseph A Kovacs; Richard A Lempicki; Igor A Sidorov; Joseph W Adelsberger; Betsey Herpin; Julia A Metcalf; Irini Sereti; Michael A Polis; Richard Davey; Jorge A Tavel; Judith Falloon; Randy Stevens; Laurie Lambert; Robin L Dewar; DJ Schwartzentruber; M R Anver; Michael Baseler; Henry Masur; Dimiter S Dimitrov; H Clifford Lane
Identification of dynamically distinct subpopulations of T lymphocytes that are differentially affected by HIV.
The Journal of experimental medicine 2001;194(12):1731-41.
2001: Michael A Polis; Igor A Sidorov; Christian Yoder; Shirley Jankelevich; Julia Metcalf; BU Mueller; M A Dimitrov; PA Pizzo; Robert Yarchoan; Dimiter S Dimitrov
Correlation between reduction in plasma HIV-1 RNA concentration 1 week after start of antiretroviral treatment and longer-term efficacy.
Lancet 2001;358(9295):1760-5.
2001: Antony S Dimitrov; Xiaodong Xiao; Dimiter S Dimitrov; Robert Blumenthal
Early intermediates in HIV-1 envelope glycoprotein-mediated fusion triggered by CD4 and co-receptor complexes.
The Journal of biological chemistry 2001;276(32):30335-41.
2000: Richard A Lempicki; Joseph A Kovacs; Michael Baseler; Joseph W Adelsberger; Robin L Dewar; Ven Natarajan; Marjorie Bosche; Julia A Metcalf; Randy A Stevens; L A Lambert; W G Alvord; Michael A Polis; Richard Davey; Dimiter S Dimitrov; H Clifford Lane
Impact of HIV-1 infection and highly active antiretroviral therapy on the kinetics of CD4+ and CD8+ T cell turnover in HIV-infected patients.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(25):13778-83.
2000: Yasuyuki Endo; Tatsuhiko Igarashi; Yoshiaki Nishimura; Charles Buckler; Alicia Buckler-White; Ronald Plishka; Dimiter S Dimitrov; Malcolm Martin
Short- and long-term clinical outcomes in rhesus monkeys inoculated with a highly pathogenic chimeric simian/human immunodeficiency virus.
Journal of virology 2000;74(15):6935-45.
2000: P Hug; Han-Ming Joseph Lin; T Korte; Xiaodong Xiao; Dimiter S Dimitrov; Ji Ming Wang; Anu Puri; Robert Blumenthal
Glycosphingolipids promote entry of a broad range of human immunodeficiency virus type 1 isolates into cell lines expressing CD4, CXCR4, and/or CCR5.
Journal of virology 2000;74(14):6377-85.
2000: Dimiter S Dimitrov
Cell biology of virus entry.
Cell 2000;101(7):697-702.
2000: Xiaodong Xiao; D Norwood; Yan-Ru Feng; M Moriuchi; Agnes Jones-Trower; Tzanko S Stantchev; H Moriuchi; Christopher C Broder; Dimiter S Dimitrov
Inefficient formation of a complex among CXCR4, CD4 and gp120 in U937 clones resistant to X4 gp120-gp41-mediated fusion.
Experimental and molecular pathology 2000;68(3):139-46.
2000: Xiaodong Xiao; A Kinter; Christopher C Broder; Dimiter S Dimitrov
Interactions of CCR5 and CXCR4 with CD4 and gp120 in human blood monocyte-derived dendritic cells.
Experimental and molecular pathology 2000;68(3):133-8.
2000: DJ Chabot; H Chen; Dimiter S Dimitrov; Christopher C Broder
N-linked glycosylation of CXCR4 masks coreceptor function for CCR5-dependent human immunodeficiency virus type 1 isolates.
Journal of virology 2000;74(9):4404-13.
1999: Richard Davey; Niranjan Bhat; Christian Yoder; Tae-Wook Chun; Julia A Metcalf; Robin L Dewar; Ven Natarajan; Richard A Lempicki; Joseph W Adelsberger; Kirk D Miller; Joseph A Kovacs; Michael A Polis; Robert E Walker; Judith Falloon; Henry Masur; Dennis Gee; Michael Baseler; Dimiter S Dimitrov; Anthony Fauci; H Clifford Lane
HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppression.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(26):15109-14.
1999: Zvi Grossman; Michael A Polis; Mark B Feinberg; Z Grossman; Itai Levi; Shirley Jankelevich; Robert Yarchoan; J Boon; F de Wolf; J M Lange; J Goudsmit; Dimiter S Dimitrov; William Paul
Ongoing HIV dissemination during HAART.
Nature medicine 1999;5(10):1099-104.
1999: Xiaodong Xiao; L Wu; Tzanko S Stantchev; Yan-Ru Feng; S Ugolini; H Chen; Z Shen; James L Riley; Christopher C Broder; Quentin J Sattentau; Dimiter S Dimitrov
Constitutive cell surface association between CD4 and CCR5.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(13):7496-501.
1999: Dimiter S Dimitrov; D Norwood; Tzanko S Stantchev; Y Feng; Xiaodong Xiao; Christopher C Broder
A mechanism of resistance to HIV-1 entry: inefficient interactions of CXCR4 with CD4 and gp120 in macrophages.
Virology 1999;259(1):1-6.
1999: Riri Shibata; Yan-Ru Feng; Dennis Gee; D Norwood; Xiaodong Xiao; Steven L Zeichner; Malcolm Martin; Dimiter S Dimitrov
Telomere dynamics in monkeys: increased cell turnover in macaques infected with chimeric simian-human immunodeficiency viruses.
Journal of medical primatology 1999;28(1):1-10.
1999: Hana Golding; J Ouyang; Marina Zaitseva; Christopher C Broder; Dimiter S Dimitrov; Cheryl K Lapham
Increased association of glycoprotein 120-CD4 with HIV type 1 coreceptors in the presence of complex-enhanced anti-CD4 monoclonal antibodies.
AIDS research and human retroviruses 1999;15(2):149-59.
1999: Yan-Ru Feng; R J Biggar; Dennis Gee; D Norwood; Steven L Zeichner; Dimiter S Dimitrov
Long-term telomere dynamics: modest increase of cell turnover in HIV-infected individuals followed for up to 14 years.
Pathobiology : journal of immunopathology, molecular and cellular biology 1999;67(1):34-8.
1998: D Norwood; Dimiter S Dimitrov
Sensitive method for measuring telomere lengths by quantifying telomeric DNA content of whole cells.
BioTechniques 1998;25(6):1040-5.
1998: Dimiter S Dimitrov; X Xiao; DJ Chabot; Christopher C Broder
HIV coreceptors.
The Journal of membrane biology 1998;166(2):75-90.
1998: BU Mueller; Steven L Zeichner; Vladimir Kuznetsov; M Heath-Chiozzi; PA Pizzo; Dimiter S Dimitrov
Individual prognoses of long-term responses to antiretroviral treatment based on virological, immunological and pharmacological parameters measured during the first week under therapy.
AIDS (London, England) 1998;12(15):F191-6.
1998: Yan-Ru Feng; D Norwood; Riri Shibata; Dennis Gee; Xiaodong Xiao; Malcolm Martin; Steven L Zeichner; Dimiter S Dimitrov
Telomere dynamics in HIV-1 infected and uninfected chimpanzees measured by an improved method based on high-resolution two-dimensional calibration of DNA sizes.
Journal of medical primatology 1998;27(5):258-65.
1997: Dimiter S Dimitrov
How do viruses enter cells? The HIV coreceptors teach us a lesson of complexity.
Cell 1997;91(6):721-30.
1997: Sherwin Lee; Keith W C Peden; Dimiter S Dimitrov; Christopher C Broder; Jody Manischewitz; Galina Denisova; Jonathan M Gershoni; Hana Golding
Enhancement of human immunodeficiency virus type 1 envelope-mediated fusion by a CD4-gp120 complex-specific monoclonal antibody.
Journal of virology 1997;71(8):6037-43.
1996: Cheryl K Lapham; J Ouyang; B Chandrasekhar; Nga Y Nguyen; Dimiter S Dimitrov; Hana Golding
Evidence for cell-surface association between fusin and the CD4-gp120 complex in human cell lines.
Science (New York, N.Y.) 1996;274(5287):602-5.
1996: Dimiter S Dimitrov
Fusin--a place for HIV-1 and T4 cells to meet.
Nature medicine 1996;2(6):640-1.
1996: Steven L Zeichner; BU Mueller; PA Pizzo; Dimiter S Dimitrov
Kinetics of HIV-1 RNA concentration changes in pediatric patients.
Pathobiology : journal of immunopathology, molecular and cellular biology 1996;64(6):289-94.
1996: Christopher C Broder; Dimiter S Dimitrov
HIV and the 7-transmembrane domain receptors.
Pathobiology : journal of immunopathology, molecular and cellular biology 1996;64(4):171-9.
1995: Hana Golding; Dimiter S Dimitrov; Jody Manischewitz; Christopher C Broder; J Robinson; S Fabian; Dan R Littman; Cheryl K Lapham
Phorbol ester-induced down modulation of tailless CD4 receptors requires prior binding of gp120 and suggests a role for accessory molecules.
Journal of virology 1995;69(10):6140-8.
1994: E Vicenzi; Dimiter S Dimitrov; Alan Engelman; TS Migone; D F Purcell; J Leonard; G Englund; Malcolm Martin
An integration-defective U5 deletion mutant of human immunodeficiency virus type 1 reverts by eliminating additional long terminal repeat sequences.
Journal of virology 1994;68(12):7879-90.
1994: H F Elson; Dimiter S Dimitrov; Robert Blumenthal
A trans-dominant mutation in human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein gp41 inhibits membrane fusion when expressed in target cells.
Molecular membrane biology 1994;11(3):165-9.
1994: Dimiter S Dimitrov; Robert Blumenthal
Photoinactivation and kinetics of membrane fusion mediated by the human immunodeficiency virus type 1 envelope glycoprotein.
Journal of virology 1994;68(3):1956-61.
1994: Hana Golding; Jody Manischewitz; L Vujcic; Robert Blumenthal; Dimiter S Dimitrov
The phorbol ester phorbol myristate acetate inhibits human immunodeficiency virus type 1 envelope-mediated fusion by modulating an accessory component(s) in CD4-expressing cells.
Journal of virology 1994;68(3):1962-9.
1993: Hana Golding; Robert Blumenthal; Jody Manischewitz; Dan R Littman; Dimiter S Dimitrov
Cell fusion mediated by interaction of a hybrid CD4.CD8 molecule with the human immunodeficiency virus type 1 envelope glycoprotein does occur after a long lag time.
Journal of virology 1993;67(11):6469-75.
1993: Dimiter S Dimitrov; G Franzoso; M Salman; Robert Blumenthal; Mark Tarshis; M F Barile; Shlomo Rottem
Mycoplasma fermentans (incognitus strain) cells are able to fuse with T lymphocytes.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1993;17 Suppl 1():S305-8.
1993: Dimiter S Dimitrov; R L Willey; H Sato; Lung-Ji Chang; Robert Blumenthal; Malcolm Martin
Quantitation of human immunodeficiency virus type 1 infection kinetics.
Journal of virology 1993;67(4):2182-90.
1993: Hana Golding; Dimiter S Dimitrov; R Blackburn; Jody Manischewitz; Robert Blumenthal; Basil Golding
Fusion of human B cell lines with HIV-1 envelope-expressing T cells is enhanced by antigen-specific Ig receptors. Possible mechanism for elimination of gp120-specific B cells in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(6):2506-16.
1993: Christopher C Broder; Dimiter S Dimitrov; R Blumenthal; Edward A Berger
The block to HIV-1 envelope glycoprotein-mediated membrane fusion in animal cells expressing human CD4 can be overcome by a human cell component(s).
Virology 1993;193(1):483-91.
1993: Dimiter S Dimitrov; Christopher C Broder; Edward A Berger; Robert Blumenthal
Calcium ions are required for cell fusion mediated by the CD4-human immunodeficiency virus type 1 envelope glycoprotein interaction.
Journal of virology 1993;67(3):1647-52.
1992: M Krumbiegel; Dimiter S Dimitrov; Anu Puri; Robert Blumenthal
Dextran sulfate inhibits fusion of influenza virus and cells expressing influenza hemagglutinin with red blood cells.
Biochimica et biophysica acta 1992;1110(2):158-64.
1992: Hana Golding; Dimiter S Dimitrov; Robert Blumenthal
LFA-1 adhesion molecules are not involved in the early stages of HIV-1 env-mediated cell membrane fusion.
AIDS research and human retroviruses 1992;8(9):1593-8.
1992: G Franzoso; Dimiter S Dimitrov; R Blumenthal; M F Barile; S Rottem
Fusion of Mycoplasma fermentans strain incognitus with T-lymphocytes.
FEBS letters 1992;303(2-3):251-4.
1992: Dimiter S Dimitrov; R L Willey; Malcolm Martin; Robert Blumenthal
Kinetics of HIV-1 interactions with sCD4 and CD4+ cells: implications for inhibition of virus infection and initial steps of virus entry into cells.
Virology 1992;187(2):398-406.
1992: Dimiter S Dimitrov; K Hillman; Jody Manischewitz; Robert Blumenthal; Hana Golding
Correlation between kinetics of soluble CD4 interactions with HIV-1-Env-expressing cells and inhibition of syncytia formation: implications for mechanisms of cell fusion and therapy for AIDS.
AIDS (London, England) 1992;6(3):249-56.
1992: Dimiter S Dimitrov; K Hillman; Jody Manischewitz; Robert Blumenthal; Hana Golding
Kinetics of soluble CD4 binding to cells expressing human immunodeficiency virus type 1 envelope glycoprotein.
Journal of virology 1992;66(1):132-8.
1992: Anu Puri; Dimiter S Dimitrov; Hana Golding; Robert Blumenthal
Interactions of CD4+ plasma membrane vesicles with HIV-1 and HIV-1 envelope glycoprotein-expressing cells.
Journal of acquired immune deficiency syndromes 1992;5(9):915-20.
1991: Dimiter S Dimitrov; Hana Golding; Robert Blumenthal
Initial stages of HIV-1 envelope glycoprotein-mediated cell fusion monitored by a new assay based on redistribution of fluorescent dyes.
AIDS research and human retroviruses 1991;7(10):799-805.