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Jonathan Dimmock

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Muath Helal; Azharul Islam; Adil J Nazarali; Brian Bandy; Umashankar Das; Jonathan R Dimmock
Mitochondrial dysfunction contributes to the cytotoxicity of some 3,5-bis(benzylidene)-4-piperidone derivatives in colon HCT-116 cells.
Ravi S P Singh; Jennifer M Auschwitz; Umashankar Das; Jonathan R Dimmock; Mark R Hickman; Susan E Leed; Jane Alcorn
From a cytotoxic agent to the discovery of a novel antimalarial agent.
Swagatika Das; Umashankar Das; Dennis K J Gorecki; Shoko Iwamoto; Masami Kawase; Tomohiko Matsuta; Joseph Molnár; Hiroshi Sakagami; Julianna Serly; Naoki Umemura; Jonathan R Dimmock
Dimeric 3,5-bis(benzylidene)-4-piperidones: a novel cluster of tumour-selective cytotoxins possessing multidrug-resistant properties.

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2013: Muath Helal; Azharul Islam; Adil J Nazarali; Brian Bandy; Umashankar Das; Jonathan R Dimmock
Mitochondrial dysfunction contributes to the cytotoxicity of some 3,5-bis(benzylidene)-4-piperidone derivatives in colon HCT-116 cells.
Bioorganic & medicinal chemistry letters 2013;23(4):1075-8.
2013: Ravi S P Singh; Jennifer M Auschwitz; Umashankar Das; Jonathan R Dimmock; Mark R Hickman; Susan E Leed; Jane Alcorn
From a cytotoxic agent to the discovery of a novel antimalarial agent.
Bioorganic & medicinal chemistry letters 2013;23(2):584-7.
2012: Swagatika Das; Umashankar Das; Dennis K J Gorecki; Shoko Iwamoto; Masami Kawase; Tomohiko Matsuta; Joseph Molnár; Hiroshi Sakagami; Julianna Serly; Naoki Umemura; Jonathan R Dimmock
Dimeric 3,5-bis(benzylidene)-4-piperidones: a novel cluster of tumour-selective cytotoxins possessing multidrug-resistant properties.
European journal of medicinal chemistry 2012;51():193-9.
2011: Swagatika Das; Umashankar Das; Erik De Clercq; Stephen G Dimmock; Dennis K J Gorecki; Carolina Lema; Armando Varela-Ramírez; Renato J Aguilera; Jan Balzarini; Jonathan R Dimmock
Bis[3,5-bis(benzylidene)-4-oxo-1-piperidinyl]amides: a novel class of potent cytotoxins.
ChemMedChem 2011;6(10):1892-9.
2011: Umashankar Das; Hari N Pati; Hiroshi Sakagami; Ken Hashimoto; Masami Kawase; Jan Balzarini; Erik De Clercq; Jonathan R Dimmock
3,5-Bis(benzylidene)-1-[3-(2-hydroxyethylthio)propanoyl]piperidin-4-ones: a novel cluster of potent tumor-selective cytotoxins.
Journal of medicinal chemistry 2011;54(9):3445-9.
2011: Ebru Mete; Halise Inci Gul; Rengul Cetin-Atalay; Umashankar Das; Ertan Sahin; Mustafa Gul; Cavit Kazaz; Jonathan R Dimmock
The design and cytotoxic evaluation of some 1-aryl-3-isopropylamino-1-propanone hydrochlorides towards human Huh-7 hepatoma cells.
Archiv der Pharmazie 2011;344(5):333-9.
2010: Swagatika Das; Umashankar Das; Hiroshi Sakagami; Ken Hashimoto; Masami Kawase; Dennis K J Gorecki; Jonathan R Dimmock
Sequential cytotoxicity: a theory examined using a series of 3,5-bis(benzylidene)-1-diethylphosphono-4-oxopiperidines and related phosphonic acids.
Bioorganic & medicinal chemistry letters 2010;20(22):6464-8.
2010: S Das; Umashankar Das; B Bandy; D K J Gorecki; Jonathan R Dimmock
2-[4-(4-Methoxyphenylcarbonyloxy)benzylidene]-6-dimethylaminomethyl cyclohexanone hydrochloride: a Mannich base which inhibits the growth of some drug-resistant strains of Mycobacterium tuberculosis.
Die Pharmazie 2010;65(11):849-50.
2010: Ravi Shankar Prasad Singh; Umashankar Das; Jonathan R Dimmock; Jane Alcorn
A general HPLC-UV method for the quantitative determination of curcumin analogues containing the 1,5-diaryl-3-oxo-1,4-pentadienyl pharmacophore in rat biomatrices.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2010;878(28):2796-802.
2010: Umashankar Das; Swagatika Das; Brian Bandy; Dennis K J Gorecki; Jonathan R Dimmock
E-2-[3-(3,4-dichlorophenyl)-1-oxo-2-propenyl]-3-methylquinoxaline-1,4-dioxide: a lead antitubercular agent which alters mitochondrial respiration in rat liver.
European journal of medicinal chemistry 2010;45(10):4682-6.
2010: Hari N Pati; Umashankar Das; Hiroshi Sakagami; Masame Kawase; Qing Chu; Qintao Wang; James P Stables; Jonathan R Dimmock
1,3-diaryl-2-propenones and 2-benzylidene-1,3-indandiones: a quest for compounds displaying greater toxicity to neoplasms than normal cells.
Archiv der Pharmazie 2010;343(9):535-41.
2010: Umashankar Das; Alireza Doroudi; H Inci Gul; Hari N Pati; Masami Kawase; Hiroshi Sakagami; Qing Chu; James P Stables; Jonathan R Dimmock
Cytotoxic 2-benzylidene-6-(nitrobenzylidene)cyclohexanones which display substantially greater toxicity for neoplasms than non-malignant cells.
Bioorganic & medicinal chemistry 2010;18(6):2219-24.
2010: Amitabh Jha; Chandrani Mukherjee; Ashok K Prasad; Virinder S Parmar; Manjula Vadaparti; Umashankar Das; Erik De Clercq; Jan Balzarini; James P Stables; Anuraag Shrivastav; Rajendra K Sharma; Jonathan R Dimmock
Derivatives of aryl amines containing the cytotoxic 1,4-dioxo-2-butenyl pharmacophore.
Bioorganic & medicinal chemistry letters 2010;20(5):1510-5.
2010: Umashankar Das; Hiroshi Sakagami; Qing Chu; Qintao Wang; Masami Kawase; Ponniah Selvakumar; Rajendra K Sharma; Jonathan R Dimmock
3,5-Bis(benzylidene)-1-[4-2-(morpholin-4-yl)ethoxyphenylcarbonyl]-4-piperidone hydrochloride: a lead tumor-specific cytotoxin which induces apoptosis and autophagy.
Bioorganic & medicinal chemistry letters 2010;20(3):912-7.
2009: Swagatika Das; Umashankar Das; Ponniah Selvakumar; Rajendra K Sharma; Jan Balzarini; Erik De Clercq; Joseph Molnár; Julianna Serly; Zoltán Baráth; Gabriele Schatte; Brian Bandy; Dennis K J Gorecki; Jonathan R Dimmock
3,5-Bis(benzylidene)-4-oxo-1-phosphonopiperidines and related diethyl esters: Potent cytotoxins with multi-drug-resistance reverting properties.
ChemMedChem 2009;4(11):1831-40.
2009: Umashankar Das; Hari N Pati; Atulya K Panda; Erik De Clercq; Jan Balzarini; Joseph Molnár; Zoltán Baráth; Imre Ocsovszki; Masami Kawase; Li Zhou; Hiroshi Sakagami; Jonathan R Dimmock
2-(3-Aryl-2-propenoyl)-3-methylquinoxaline-1,4-dioxides: a novel cluster of tumor-specific cytotoxins which reverse multidrug resistance.
Bioorganic & medicinal chemistry 2009;17(11):3909-15.
2009: Ponniah Selvakumar; Ashakumary Lakshmikuttyamma; Umashankar Das; Hari N Pati; Jonathan R Dimmock; Rajendra K Sharma
NC2213: a novel methionine aminopeptidase 2 inhibitor in human colon cancer HT29 cells.
Molecular cancer 2009;8():65.
2009: Umashankar Das; Rajendra K Sharma; Jonathan R Dimmock
1,5-diaryl-3-oxo-1,4-pentadienes: a case for antineoplastics with multiple targets.
Current medicinal chemistry 2009;16(16):2001-20.
2009: Hari N Pati; Umashankar Das; Swagatika Das; Brian Bandy; Erik De Clercq; Jan Balzarini; Masami Kawase; Hiroshi Sakagami; J Wilson Quail; James P Stables; Jonathan R Dimmock
The cytotoxic properties and preferential toxicity to tumour cells displayed by some 2,4-bis(benzylidene)-8-methyl-8-azabicyclo[3.2.1] octan-3-ones and 3,5-bis(benzylidene)-1-methyl-4-piperidones.
European journal of medicinal chemistry 2009;44(1):54-62.
2008: Halise Inci Gul; Kadir Ozden Yerdelen; Umashankar Das; Mustafa Gul; Bulbul Pandit; Pui-Kai Li; Jonathan R Dimmock
Synthesis and cytotoxicity of novel 3-aryl-1-(3'-dibenzylaminomethyl-4'-hydroxyphenyl)-propenones and related compounds.
Chemical & pharmaceutical bulletin 2008;56(12):1675-81.
2008: Ryan Davis; Umashankar Das; Hilary Mackay; Toni Brown; Susan Mooberry; Jonathan R Dimmock; Moses Lee; Hari Pati
Syntheses and cytotoxic properties of the curcumin analogs 2,6-bis(benzylidene)-4-phenylcyclohexanones.
Archiv der Pharmazie 2008;341(7):440-5.
2008: Umashankar Das; Joseph Molnár; Zoltán Baráth; Zsuzsanna Bata; Jonathan R Dimmock
1-[4-(2-Aminoethoxy)phenylcarbonyl]-3,5-bis-(benzylidene)-4-oxopiperidines: a novel series of highly potent revertants of P-glycoprotein associated multidrug resistance.
Bioorganic & medicinal chemistry letters 2008;18(12):3484-7.
2008: Umashankar Das; Alireza Doroudi; Swagatika Das; Brian Bandy; Jan Balzarini; Erik De Clercq; Jonathan R Dimmock
E,E-2-Benzylidene-6-(nitrobenzylidene)cyclohexanones: syntheses, cytotoxicity and an examination of some of their electronic, steric, and hydrophobic properties.
Bioorganic & medicinal chemistry 2008;16(11):6261-8.
2008: Hari N Pati; Umashankar Das; Masami Kawase; Hiroshi Sakagami; Jan Balzarini; Erik De Clercq; Jonathan R Dimmock
1-Aryl-2-dimethylaminomethyl-2-propen-1-one hydrochlorides and related adducts: A quest for selective cytotoxicity for malignant cells.
Bioorganic & medicinal chemistry 2008;16(10):5747-53.
2008: Umashankar Das; Swagatika Das; Brian Bandy; James P Stables; Jonathan R Dimmock
N-Aroyl-3,5-bis(benzylidene)-4-piperidones: a novel class of antimycobacterial agents.
Bioorganic & medicinal chemistry 2008;16(7):3602-7.
2008: Pal Perjesi; Umashankar Das; Erik De Clercq; Jan Balzarini; Masame Kawase; Hiroshi Sakagami; James P Stables; Tamas Lorand; Zsuzsanna Rozmer; Jonathan R Dimmock
Design, synthesis and antiproliferative activity of some 3-benzylidene-2,3-dihydro-1-benzopyran-4-ones which display selective toxicity for malignant cells.
European journal of medicinal chemistry 2008;43(4):839-45.
2008: Hari N Pati; Umashankar Das; J Wilson Quail; Masami Kawase; Hiroshi Sakagami; Jonathan R Dimmock
Cytotoxic 3,5-bis(benzylidene)piperidin-4-ones and N-acyl analogs displaying selective toxicity for malignant cells.
European journal of medicinal chemistry 2008;43(1):1-7.
2007: Amitabh Jha; Chandrani Mukherjee; Ashok K Prasad; Virinder S Parmar; Erik De Clercq; Jan Balzarini; James P Stables; Elias K Manavathu; Anuraag Shrivastav; Rajendra K Sharma; Kurt H Nienaber; Gordon A Zello; Jonathan R Dimmock
E,E,E-1-(4-Arylamino-4-oxo-2-butenoyl)-3,5-bis(arylidene)-4-piperidones: a topographical study of some novel potent cytotoxins.
Bioorganic & medicinal chemistry 2007;15(17):5854-65.
2007: Umashankar Das; Ponniah Selvakumar; Rajendra K Sharma; Thomas A Haas; Jonathan R Dimmock
N-acyl-3,5-bis(arylidene)-4-piperidones and related compounds which stimulate fyn kinase.
Journal of enzyme inhibition and medicinal chemistry 2007;22(4):451-5.
2007: Umashankar Das; Masami Kawase; Hiroshi Sakagami; Atsushi Ideo; Jun Shimada; Joseph Molnár; Zoltán Baráth; Zsuzsanna Bata; Jonathan R Dimmock
3-(3,4,5-Trimethoxyphenyl)-1-oxo-2-propene: a novel pharmacophore displaying potent multidrug resistance reversal and selective cytotoxicity.
Bioorganic & medicinal chemistry 2007;15(10):3373-80.
2007: Hari N Pati; Umashankar Das; Irving Javier Ramirez-Erosa; Donna Mae Dunlop; Robert Allan Hickie; Jonathan R Dimmock
Alpha-substituted 1-aryl-3-dimethylaminopropanone hydrochlorides: potent cytotoxins towards human WiDr colon cancer cells.
Chemical & pharmaceutical bulletin 2007;55(4):511-5.
2007: Hari N Pati; Umashankar Das; Erik De Clercq; Jan Balzarini; Jonathan R Dimmock
Molecular modifications of 2-arylidene-1-indanones leading to increased cytotoxic potencies.
Journal of enzyme inhibition and medicinal chemistry 2007;22(1):37-42.
2007: Hari N Pati; Umashankar Das; Rajendra K Sharma; Jonathan R Dimmock
Cytotoxic thiol alkylators.
Mini reviews in medicinal chemistry 2007;7(2):131-9.
2007: Umashankar Das; Jane Alcorn; Anuraag Shrivastav; Rajendra K Sharma; Erik De Clercq; Jan Balzarini; Jonathan R Dimmock
Design, synthesis and cytotoxic properties of novel 1-[4-(2-alkylaminoethoxy)phenylcarbonyl]-3,5-bis(arylidene)-4-piperidones and related compounds.
European journal of medicinal chemistry 2007;42(1):71-80.
2007: Ponniah Selvakumar; Ashakumary Lakshmikuttyamma; Anuraag Shrivastav; Shankar B Das; Jonathan R Dimmock; Rajendra K Sharma
Potential role of N-myristoyltransferase in cancer.
Progress in lipid research 2007;46(1):1-36.
2006: Anuraag Shrivastav; Nand K Singh; Pratibha Tripathi; Theresa George; Jonathan R Dimmock; Rajendra K Sharma
Copper(II) and manganese(III) complexes of N'-[(2-hydroxy phenyl) carbonothioyl] pyridine-2-carbohydrazide: novel therapeutic agents for cancer.
Biochimie 2006;88(9):1209-16.
2006: Amitabh Jha; Jonathan R Dimmock
1-N-(Arylmaleamoyl)-3,5-bis(phenylmethylene)4-piperidones: a novel class of antimycobacterial agents.
Die Pharmazie 2006;61(6):562-3.
2006: Umashankar Das; Halise Inci Gul; Jane Alcorn; Anuraag Shrivastav; Theresa George; Rajendra K Sharma; Kurt H Nienaber; Erik De Clercq; Jan Balzarini; Masami Kawase; Noriyuki Kan; Toru Tanaka; Satoru Tani; Karl A Werbovetz; Adam J Yakovich; Elias K Manavathu; James P Stables; Jonathan R Dimmock
Cytotoxic 5-aryl-1-(4-nitrophenyl)-3-oxo-1,4-pentadienes mounted on alicyclic scaffolds.
European journal of medicinal chemistry 2006;41(5):577-85.
2006: Ponniah Selvakumar; Ashakumary Lakshmikuttyamma; Jonathan R Dimmock; Rajendra K Sharma
Methionine aminopeptidase 2 and cancer.
Biochimica et biophysica acta 2006;1765(2):148-54.
2005: Stanislaw M Stepkowski; Judy Kao; Mou-Er Wang; Neelam Tejpal; Hemangshu Podder; Lucrezia Furian; Jonathan R Dimmock; Amitabh Jha; Umashankar Das; Barry D Kahan; Robert A Kirken
The Mannich base NC1153 promotes long-term allograft survival and spares the recipient from multiple toxicities.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(7):4236-46.
2005: Jonathan R Dimmock; Umashankar Das; Halise Inci Gul; Masami Kawase; Hiroshi Sakagami; Zoltán Baráth; Imre Ocsovsky; Joseph Molnár
3-Arylidene-1-(4-nitrophenylmethylene)-3,4-dihydro-1H-naphthalen-2-ones and related compounds displaying selective toxicity and reversal of multidrug resistance in neoplastic cells.
Bioorganic & medicinal chemistry letters 2005;15(6):1633-6.
2005: Anuraag Shrivastav; Ponniah Selvakumar; Gagan Bajaj; Yanjie Lu; Jonathan R Dimmock; Rajendra K Sharma
Regulation of N-myristoyltransferase by novel inhibitor proteins.
Cell biochemistry and biophysics 2005;43(1):189-202.
2004: Ponniah Selvakumar; Ashakumary Lakshmikuttyamma; Zoe Lawman; Keith Bonham; Jonathan R Dimmock; Rajendra K Sharma
Expression of methionine aminopeptidase 2, N-myristoyltransferase, and N-myristoyltransferase inhibitor protein 71 in HT29.
Biochemical and biophysical research communications 2004;322(3):1012-7.
2004: Jonathan R Dimmock; S G R Gunda; Sarvesh C Vashishtha; Gordon A Zello; Umashankar Das; Kurt H Nienaber; James P Stables; Theresa M Allen; Cheryl L Santos
Anticonvulsants containing the N-(3-aryl-2-propenoyl) amido pharmacophore.
Journal of enzyme inhibition and medicinal chemistry 2004;19(4):303-12.
2004: Jonathan R Dimmock; NM Kandepu; Umashankar Das; Gordon A Zello; Kurt H Nienaber
Antimycobacterial arylidenecyclohexanones and related Mannich bases.
Die Pharmazie 2004;59(7):502-5.
2004: Ponniah Selvakumar; Ashakumary Lakshmikuttyamma; Mohammed Khysar Pasha; Martin J King; Douglas J H Olson; Sumiko Mori; Andrew R S Ross; Kiyoshi Hayashi; Jonathan R Dimmock; Rajendra K Sharma
N-myristoyltransferase inhibitor protein is homologous to heat shock cognate protein 70.
Journal of cellular biochemistry 2004;92(3):573-8.
2004: Ponniah Selvakumar; Ashakumary Lakshmikuttyamma; Rani Kanthan; Selliah Chandra Kanthan; Jonathan R Dimmock; Rajendra K Sharma
High expression of methionine aminopeptidase 2 in human colorectal adenocarcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(8):2771-5.
2004: Mohammed Khysar Pasha; Ponniah Selvakumar; Lakshmikuttyamma Ashakumary; Mabood Qureshi; Frank S Guziec; Jonathan R Dimmock; Ronald L Felsted; Constance J Glover; Rajendra K Sharma
Lipidic inhibitors of human N-myristoyltransferase.
International journal of molecular medicine 2004;13(4):557-63.
2004: Sweta Gowda; Anuraag Shrivastav; Ponniah Selvakumar; Jonathan R Dimmock; Rajendra K Sharma
A novel inhibitor protein of N-myristoyltransferase from Escherichia coli.
Biochemical and biophysical research communications 2004;314(4):984-7.
2004: Jonathan R Dimmock; Mahmood Chamankhah; Umashankar Das; Gordon A Zello; J Wilson Quail; J Yang; Kurt H Nienaber; Rajendra K Sharma; Ponniah Selvakumar; Jan Balzarini; Erik De Clercq; James P Stables
Cytotoxic and topographical properties of 6-arylidene-2-dimethylaminomethylcyclohexanone hydrochlorides and related compounds.
Journal of enzyme inhibition and medicinal chemistry 2004;19(1):1-10.
2004: Sarvesh C Vashishtha; Gordon A Zello; Kurt H Nienaber; Jan Balzarini; Erik De Clercq; James P Stables; Jonathan R Dimmock
Cytotoxic and anticonvulsant aryloxyaryl Mannich bases and related compounds.
European journal of medicinal chemistry 2004;39(1):27-35.
2003: Anuraag Shrivastav; Mohammed Khysar Pasha; Ponniah Selvakumar; Sweta Gowda; Douglas J H Olson; Andrew R S Ross; Jonathan R Dimmock; Rajendra K Sharma
Potent inhibitor of N-myristoylation: a novel molecular target for cancer.
Cancer research 2003;63(22):7975-8.
2003: Jonathan R Dimmock; Amitabh Jha; Gordon A Zello; Rajendra K Sharma; Anuraag Shrivastav; Ponniah Selvakumar; Theresa M Allen; Cheryl L Santos; Jan Balzarini; Erik De Clercq; Elias K Manavathu; James P Stables
3,5-bis(phenylmethylene)-1-(N-arylmaleamoyl)-4-piperidones: a novel group of cytotoxic agents.
Journal of enzyme inhibition and medicinal chemistry 2003;18(4):325-32.
2003: Jonathan R Dimmock; Maniyan Padmanilayam; Umashankar Das; Gordon A Zello; Rajendra K Sharma; Anuraag Shrivastav; Ponniah Selvakumar; Mohammed Khysar Pasha; Kurt H Nienaber; Jeremy S Lee; Theresa M Allen; Cheryl L Santos; Jan Balzarini; Erik De Clercq
Cytotoxic mannich bases of 1-arylidene-2-tetralones.
Journal of enzyme inhibition and medicinal chemistry 2003;18(4):313-24.
2003: Jonathan R Dimmock; Amitabh Jha; Gordon A Zello; Theresa M Allen; Cheryl L Santos; Jan Balzarini; Erik De Clercq; Elias K Manavathu; James P Stables
Cytotoxic 4'-aminochalcones and related compounds.
Die Pharmazie 2003;58(4):227-32.
2003: Jonathan R Dimmock; Gordon A Zello; Sarvesh C Vashishtha; S J Hayes; Srinivas Mutalik; S Kumar; Madhavacharya Venkatesh; Nayanabhirama Udupa
A toxicological evaluation of 2-dimethylaminomethyl-1-phenyl-2-propen-1-one hydrochloride.
Die Pharmazie 2003;58(2):136-9.
2003: Jonathan R Dimmock; Maniyan Padmanilayam; Gordon A Zello; Kurt H Nienaber; Theresa M Allen; Cheryl L Santos; Erik De Clercq; Jan Balzarini; Elias K Manavathu; James P Stables
Cytotoxic analogues of 2,6-bis(arylidene)cyclohexanones.
European journal of medicinal chemistry 2003;38(2):169-77.
2002: Jonathan R Dimmock; Amitabh Jha; Gordon A Zello; J Wilson Quail; Eliud O Oloo; Kurt H Nienaber; Earl S Kowalczyk; Theresa M Allen; Cheryl L Santos; Erik De Clercq; Jan Balzarini; Elias K Manavathu; James P Stables
Cytotoxic N-[4-(3-aryl-3-oxo-1-propenyl)phenylcarbonyl]-3,5-bis(phenylmethylene)-4-piperidones and related compounds.
European journal of medicinal chemistry 2002;37(12):961-72.
2002: Mohammed Khysar Pasha; Jonathan R Dimmock; Morley D Hollenberg; Rajendra K Sharma
Enhanced activity of human N-myristoyltransferase by dimethyl sulfoxide and related solvents in the presence of serine/threonine-containing peptide substrates.
Biochemical pharmacology 2002;64(10):1461-7.
2002: Jonathan R Dimmock; Maniyan P Padmanilyam; Gordon A Zello; J Wilson Quail; Eliud O Oloo; Jared S Prisciak; Heinz-Bernhard Kraatz; Arten Cherkasov; Jeremy S Lee; Theresa M Allen; Cheryl L Santos; Elias K Manavathu; Erik De Clercq; Jan Balzarini; James P Stables
Cytotoxic 1,3-diarylidene-2-tetralones and related compounds.
European journal of medicinal chemistry 2002;37(10):813-24.
2002: Ponniah Selvakumar; Mohammed Khysar Pasha; Lakshmikuttyamma Ashakumary; Jonathan R Dimmock; Rajendra K Sharma
Myristoyl-CoA:protein N-myristoyltransferase: a novel molecular approach for cancer therapy (Review).
International journal of molecular medicine 2002;10(4):493-500.
2002: Jonathan R Dimmock; Gordon A Zello; Eliud O Oloo; J Wilson Quail; Heinz-Bernhard Kraatz; Pal Perjesi; Ferenc Aradi; Krisztina Takács-Novák; Theresa M Allen; Cheryl L Santos; Jan Balzarini; Erik De Clercq; James P Stables
Correlations between cytotoxicity and topography of some 2-arylidenebenzocycloalkanones determined by X-ray crystallography.
Journal of medicinal chemistry 2002;45(14):3103-11.
2002: Jonathan R Dimmock; Amitabh Jha; Praveen Kumar; Gordon A Zello; J Wilson Quail; Eliud O Oloo; Jennifer J Oucharek; Mohammed Khysar Pasha; Dallas P Seitz; Rajendra K Sharma; Theresa M Allen; Cheryl L Santos; Elias K Manavathu; Erik De Clercq; Jan Balzarini; James P Stables
Cytotoxic 1,4-bis(2-oxo-1-cycloalkylmethylene)benzenes and related compounds.
European journal of medicinal chemistry 2002;37(1):35-44.
2001: Jonathan R Dimmock; Praveen Kumar; Amitabh Jha; J Wilson Quail
Synthesis and cytotoxicity of 1-phenyl-3,3-diacetoxy-1-propene.
Die Pharmazie 2001;56(9):744-5.
2001: Sarvesh C Vashishtha; Theresa M Allen; S Halleran; J Szydlowski; Cheryl L Santos; Erik De Clercq; J Balzarani; Jonathan R Dimmock
Cytotoxic and anticancer properties of some 4-aryl-3-arylcarbonyl-1-ethyl-4-piperidinols and related compounds.
Die Pharmazie 2001;56(5):390-3.
2001: Elias K Manavathu; Jonathan R Dimmock; Sarvesh C Vashishtha; Pranatharthi H Chandrasekar
Inhibition of H(+)-ATPase-mediated proton pumping in Cryptococcus neoformans by a novel conjugated styryl ketone.
The Journal of antimicrobial chemotherapy 2001;47(4):491-4.
2001: Jonathan R Dimmock; Maniyan Padmanilayam; R N Puthucode; Adil J Nazarali; NL Motaganahalli; Gordon A Zello; J Wilson Quail; Eliud O Oloo; Heinz-Bernhard Kraatz; Jared S Prisciak; Theresa M Allen; Cheryl L Santos; Jan Balzarini; Erik De Clercq; Elias K Manavathu
A conformational and structure-activity relationship study of cytotoxic 3,5-bis(arylidene)-4-piperidones and related N-acryloyl analogues.
Journal of medicinal chemistry 2001;44(4):586-93.
2000: Jonathan R Dimmock; Praveen Kumar; Adil J Nazarali; NL Motaganahalli; TP Kowalchuk; MA Beazely; J Wilson Quail; Eliud O Oloo; Theresa M Allen; J Szydlowski; E DeClercq; Jan Balzarini
Cytotoxic 2,6-bis(arylidene)cyclohexanones and related compounds.
European journal of medicinal chemistry 2000;35(11):967-77.
2000: Jonathan R Dimmock; NM Kandepu; Adil J Nazarali; NL Motaganahalli; TP Kowalchuk; U Pugazhenthi; Jared S Prisciak; J Wilson Quail; Theresa M Allen; R LeClerc; Cheryl L Santos; Erik De Clercq; Jan Balzarini
Sequential cytotoxicity: a theory evaluated using novel 2-[4-(3-aryl-2-propenoyloxy)phenylmethylene]cyclohexanones and related compounds.
Journal of medicinal chemistry 2000;43(21):3933-40.
2000: Jonathan R Dimmock; Sarvesh C Vashishtha; James P Stables
Ureylene anticonvulsants and related compounds.
Die Pharmazie 2000;55(7):490-4.
2000: Jonathan R Dimmock; Sarvesh C Vashishtha; James P Stables
Anticonvulsant properties of various acetylhydrazones, oxamoylhydrazones and semicarbazones derived from aromatic and unsaturated carbonyl compounds.
European journal of medicinal chemistry 2000;35(2):241-8.
1999: Elias K Manavathu; Jonathan R Dimmock; Sarvesh C Vashishtha; Pranatharthi H Chandrasekar
Proton-pumping-ATPase-targeted antifungal activity of a novel conjugated styryl ketone.
Antimicrobial agents and chemotherapy 1999;43(12):2950-9.
1999: Jonathan R Dimmock; D W Elias; MA Beazely; NM Kandepu
Bioactivities of chalcones.
Current medicinal chemistry 1999;6(12):1125-49.
1999: Jonathan R Dimmock; NM Kandepu; Adil J Nazarali; TP Kowalchuk; NL Motaganahalli; J Wilson Quail; P A Mykytiuk; Gerald F Audette; Lata Prasad; Pal Perjesi; Theresa M Allen; Cheryl L Santos; J Szydlowski; Erik De Clercq; Jan Balzarini
Conformational and quantitative structure-activity relationship study of cytotoxic 2-arylidenebenzocycloalkanones.
Journal of medicinal chemistry 1999;42(8):1358-66.
1999: Jonathan R Dimmock; Hugh A Semple; S John; MA Beazely; G D Abrams
Isolation and identification of the major urinary metabolite of 4-(4-fluorophenoxy)benzaldehyde semicarbazone after oral dosing to rats.
Die Pharmazie 1999;54(4):260-2.
1998: Elias K Manavathu; Jonathan R Dimmock; Sarvesh C Vashishtha; Jessica L Cutright; Pranatharthi H Chandrasekar
In-vitro and in-vivo susceptibility of Aspergillus fumigatus to a novel conjugated styryl ketone.
The Journal of antimicrobial chemotherapy 1998;42(5):585-90.
1998: Jonathan R Dimmock; Sarvesh C Vashishtha; J Wilson Quail; U Pugazhenthi; Zbigniew Zimpel; Athena Sudom; Theresa M Allen; GY Kao; Jan Balzarini; Erik De Clercq
4-(beta-Arylvinyl)-3-(beta-arylvinylketo)-1-ethyl-4-piperidinols and related compounds: a novel class of cytotoxic and anticancer agents.
Journal of medicinal chemistry 1998;41(21):4012-20.
1998: Jonathan R Dimmock; Sarvesh C Vashishtha; S A Patil; Nayanabhirama Udupa; S B Dinesh; P Uma Devi; R Kamath
Cytotoxic and anticancer activities of some 1-aryl-2-dimethylaminomethyl-2-propen-1-one hydrochlorides.
Die Pharmazie 1998;53(10):702-6.
1998: Sarvesh C Vashishtha; Adil J Nazarali; Jonathan R Dimmock
Application of fluorescence microscopy to measure apoptosis in Jurkat T cells after treatment with a new investigational anticancer agent (N.C.1213).
Cellular and molecular neurobiology 1998;18(4):437-45.
1998: Sarvesh C Vashishtha; Jonathan R Dimmock; Elias K Manavathu
Antifungal activity of some quaternary ammonium salts of 4-(2-arylvinyl)-3-(3-aryl-2-propenoyl)-1-ethyl-4-piperidinols and related compounds.
Die Pharmazie 1998;53(7):499-500.
1998: Jonathan R Dimmock; NM Kandepu; M Hetherington; J Wilson Quail; U Pugazhenthi; Athena Sudom; Mahmood Chamankhah; P Rose; E Pass; Theresa M Allen; S Halleran; J Szydlowski; Bulent Mutus; M Tannous; Elias K Manavathu; Timothy G Myers; Erik De Clercq; Jan Balzarini
Cytotoxic activities of Mannich bases of chalcones and related compounds.
Journal of medicinal chemistry 1998;41(7):1014-26.
1998: Jonathan R Dimmock; S N Pandeya; Theresa M Allen; GY Kao
Mannich bases of arylalicyclic ketones and related quaternary ammonium compounds with antileukemic properties.
Die Pharmazie 1998;53(3):201-2.
1998: Elias K Manavathu; Sarvesh C Vashishtha; George J Alangaden; Jonathan R Dimmock
In vitro antifungal activity of some Mannich bases of conjugated styryl ketones.
Canadian journal of microbiology 1998;44(1):74-9.
1997: Jonathan R Dimmock; Praveen Kumar; Theresa M Allen; GY Kao; S Halleran; Jan Balzarini; Erik De Clercq
Synthesis and cytotoxic evaluation of some carbohydrazones and thiocarbohydrazones of various unsaturated ketones and related Mannich bases.
Die Pharmazie 1997;52(3):182-6.
1996: Jonathan R Dimmock; R N Puthucode; J M Smith; M Hetherington; J Wilson Quail; U Pugazhenthi; T Lechler; J P Stables
(Aryloxy)aryl semicarbazones and related compounds: a novel class of anticonvulsant agents possessing high activity in the maximal electroshock screen.
Journal of medicinal chemistry 1996;39(20):3984-97.
1996: Jonathan R Dimmock; R N Puthucode; M S Lo; J Wilson Quail; J Yang; J P Stables
Structural modifications of the primary amino group of anticonvulsant aryl semicarbazones.
Die Pharmazie 1996;51(2):83-8.
1995: Jonathan R Dimmock; Sarvesh C Vashishtha; J P Stables
Anticonvulsant semicarbazones: are aryl groups necessary for activity?
Die Pharmazie 1995;50(12):823-4.
1995: Jonathan R Dimmock; Mahmood Chamankhah; A Seniuk; T M Allen; G Y Kao; S Halleran
Synthesis and cytotoxic evaluation of some Mannich bases of alicyclic ketones.
Die Pharmazie 1995;50(10):668-71.
1995: Jonathan R Dimmock; P Kumar; M Chen; J Wilson Quail; J Yang; T M Allen; G Y Kao
Synthesis and cytotoxic evaluation of mesna adducts of some 1-aryl-4,4-dimethyl-5-(1-piperidino)-1-penten-3-one hydrochlorides.
Die Pharmazie 1995;50(7):449-53.
1995: Jonathan R Dimmock; Mahmood Chamankhah; T M Allen; S Hallran
Mannich bases of 2-arylmethylenecyclohexanone with cytotoxic activity.
Die Pharmazie 1995;50(3):221-2.
1994: Jonathan R Dimmock; P Kumar; Elias K Manavathu; N Obedeanu; J Grewal
Activity of some Mannich bases of conjugated styryl ketones against Candida albicans.
Die Pharmazie 1994;49(12):909-12.
1994: Jonathan R Dimmock; V K Arora; J Wilson Quail; U Pugazhenthi; T M Allen; G Y Kao; E De Clercq
Cytotoxic evaluation of some 3,5-diarylidene-4-piperidones and various related quaternary ammonium compounds and analogs.
Journal of pharmaceutical sciences 1994;83(8):1124-30.
1994: Jonathan R Dimmock; V K Arora; M Chen; T M Allen; G Y Kao
Cytotoxic evaluation of some N-acyl and N-acyloxy analogues of 3,5-bis(arylidene)-4-piperidones.
Drug design and discovery 1994;12(1):19-28.
1994: Jonathan R Dimmock; K K Sidhu; M Chen; J Li; J Wilson Quail; T M Allen; G Y Kao
Synthesis and cytotoxic evaluation of some cyclic arylidene ketones and related oximes, oxime esters, and analogs.
Journal of pharmaceutical sciences 1994;83(6):852-8.
1994: Jonathan R Dimmock; G B Baker
Anticonvulsant activities of 4-bromobenzaldehyde semicarbazone.
Epilepsia 1994;35(3):648-55.
1993: S N Pandeya; Jonathan R Dimmock
Recent evaluations of thiosemicarbazones and semicarbazones and related compounds for antineoplastic and anticonvulsant activities.
Die Pharmazie 1993;48(9):659-66.
1993: Jonathan R Dimmock; K K Sidhu; R S Thayer; P Mack; M J Duffy; R S Reid; J Wilson Quail; U Pugazhenthi; A Ong; J A Bikker
Anticonvulsant activities of some arylsemicarbazones displaying potent oral activity in the maximal electroshock screen in rats accompanied by high protection indices.
Journal of medicinal chemistry 1993;36(16):2243-52.
1993: Daniel Sexton; Jonathan R Dimmock; Bulent Mutus
A spectrophotometric glutathione S-transferase assay displaying alpha-class selectivity utilizing 1-p-chlorophenyl-4,4-dimethyl-5-diethylamino-1-penten-3- one hydrobromide.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1993;71(1-2):98-101.
1992: Jonathan R Dimmock; K M Advikolanu; H E Scott; M J Duffy; R S Reid; J Wilson Quail; Z Jia; R A Hickie; T M Allen; J M Rutledge
Evaluation of cytotoxicity of some Mannich bases of various aryl and arylidene ketones and their corresponding arylhydrazones.
Journal of pharmaceutical sciences 1992;81(12):1147-52.
1992: Jonathan R Dimmock; K K Sidhu; J Wilson Quail; Z Jia; M J Duffy; R S Reid; D Lynn Kirkpatrick; L Zhu; S M Fletcher
Synthesis and cytotoxic evaluation of some 6-arylidene-2-(alpha-hydroxyamino-alpha-arylmethyl)cyclohexanone oximes and related compounds.
Journal of pharmaceutical sciences 1992;81(11):1059-64.
1992: Jonathan R Dimmock; V K Arora; M J Duffy; R S Reid; T M Allen; G Y Kao
Evaluation of some N-acyl analogues of 3,5-bis(arylidene)-4-piperidones for cytotoxic activity.
Drug design and discovery 1992;8(4):291-9.
1992: Jonathan R Dimmock; S S Jonnalagadda; O A Phillips; E Erciyas; Krishnamurthy Shyam; Hugh A Semple
Anticonvulsant properties of some Mannich bases of conjugated arylidene ketones.
Journal of pharmaceutical sciences 1992;81(5):436-40.
1992: Jonathan R Dimmock; V K Arora; Hugh A Semple; Jeremy S Lee; T M Allen; G Y Kao
3,5-Bis-arylidene-1-methyl-4-piperidone methohalides and related compounds with activity against L 1210 cells and DNA binding properties.
Die Pharmazie 1992;47(4):246-8.
1991: Jonathan R Dimmock; S A Patil; Krishnamurthy Shyam
Evaluation of some Mannich bases of 1-aryl-1-ethanones and related ketones for anticonvulsant activities.
Die Pharmazie 1991;46(7):538-9.
1991: D Thomas; K Klein; Elias K Manavathu; Jonathan R Dimmock; Bulent Mutus
Glutathione levels during thermal induction of the yeast-to-mycelial transition in Candida albicans.
FEMS microbiology letters 1991;61(2-3):331-4.
1990: Jonathan R Dimmock; E Erciyas; G E Bigam; D Lynn Kirkpatrick; M M Duke
Cytotoxicity of Mannich bases of alpha-arylidene-beta-ketoesters and related compounds against EMT6 mammary carcinoma cells.
Drug design and delivery 1990;7(1):51-8.
1990: Jonathan R Dimmock; E Erciyas; K K Sidhu; X Luo; PG Mezey; T M Allen; L Murray
Charge densities of atoms of conjugated styryl ketones having activity against L1210 leukemia cells.
Drug design and delivery 1990;7(1):45-9.
1990: Jonathan R Dimmock; E Erciyas; S K Raghavan; D Lynn Kirkpatrick
Evaluation of the cytotoxicity of some Mannich bases of acetophenone against the EMT6 tumour.
Die Pharmazie 1990;45(10):755-7.
1990: Jonathan R Dimmock; V K Arora; S L Wonko; N W Hamon; J Wilson Quail; Z Jia; Robert C Warrington; W D Fang; Jeremy S Lee
3,5-Bis-benzylidene-4-piperidones and related compounds with high activity towards P388 leukemia cells.
Drug design and delivery 1990;6(3):183-94.
1990: C G Rousseaux; Hugh G G Townsend; O A Phillips; Jonathan R Dimmock
Toxicologic studies on a novel antineoplastic bis-Mannich base, derived from a conjugated styryl ketone.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1990;14(2):318-26.
1989: Jonathan R Dimmock; N W Hamon; C A De Gooijer; G F Grant; S S Jonnalagadda; D S Hancock
Effect of some 4-alkyl-5-dimethylamino-1-phenyl-1-penten-3-one hydrochlorides and related compounds on respiration in mouse liver mitochondria.
Die Pharmazie 1989;44(8):560-2.
1989: Bulent Mutus; J D Wagner; C J Talpas; Jonathan R Dimmock; O A Phillips; R S Reid
1-p-chlorophenyl-4,4-dimethyl-5-diethylamino-1-penten-3-one hydrobromide, a sulfhydryl-specific compound which reacts irreversibly with protein thiols but reversibly with small molecular weight thiols.
Analytical biochemistry 1989;177(2):237-43.
1988: Jonathan R Dimmock; E Erciyas; D Lynn Kirkpatrick; K M King
Evaluation of some azines of aminomethylacetophenones and related quaternary ammonium compounds versus the EMT6 tumour.
Die Pharmazie 1988;43(9):614-6.
1988: Jonathan R Dimmock; S S Jonnalagadda; D M Leek; Robert C Warrington; W D Fang
Evaluation of Mannich bases of styryl ketones and related hydrazones for activity against P388 leukemia.
Neoplasma 1988;35(6):715-24.
1987: Jonathan R Dimmock; J M Brenner; O A Phillips
Evaluation of some benzenesulphonylhydrazones of aryl aldehydes and ketones as antiepileptic agents.
Die Pharmazie 1987;42(6):376-8.
1986: Jonathan R Dimmock; N W Hamon; T A Waslen; S A Patil; O A Phillips; S S Jonnalagadda; D S Hancock
Effect of some Mannich bases derived from aryl-alpha, beta-unsaturated ketones on respiration in mouse liver mitochondria.
Die Pharmazie 1986;41(6):441-2.
1986: Jonathan R Dimmock; S A Patil
A retro-Mannich reaction of a bis-Mannich base.
Die Pharmazie 1986;41(4):284.
1985: Jonathan R Dimmock; Krishnamurthy Shyam; N W Hamon; S A Patil; P J Smith
bis-Mannich bases of styryl ketones as antileukemic agents.
Neoplasma 1985;32(1):85-91.
1984: Jonathan R Dimmock; Krishnamurthy Shyam; P J Smith
Decomposition of 1-aryl-3-dimethylamino-1-propanone methobromides under weakly acidic conditions.
Die Pharmazie 1984;39(7):467-70.
1984: Jonathan R Dimmock; Krishnamurthy Shyam; B M Logan; P J Smith; B M Cross
Syntheses and evaluation of some mannich bases derived from acetophenones against P388 lymphocytic leukemia and toxicological assessment of 3-dimethyl-amino-2-dimethylaminomethyl-1-(4-methoxyphenyl)-1-propanone dihydrochloride in rats.
Journal of pharmaceutical sciences 1984;73(4):471-7.
1983: Jonathan R Dimmock; Krishnamurthy Shyam; N W Hamon; B M Logan; S K Raghavan; D J Harwood; P J Smith
Evaluation of some Mannich bases derived from substituted acetophenones against P-388 lymphocytic leukemia and on respiration in isolated rat liver mitochondria.
Journal of pharmaceutical sciences 1983;72(8):887-94.
1982: Jonathan R Dimmock; D Lynn Kirkpatrick; N G Webb; B M Cross
Synthesis and evaluation of some alkoxy-, chloro-, and acyloxy-conjugated styryl ketones against P-388 lymphocytic leukemia and an examination of the metabolism and toxicological effects of 1-(m-ethoxymethyloxyphenyl)-1-nonen-3-one in rats.
Journal of pharmaceutical sciences 1982;71(9):1000-7.
1982: N W Hamon; D Lynn Kirkpatrick; E W Chow; Jonathan R Dimmock
Effect of 4-dimethylaminomethyl-1-(3-hydroxyphenyl)-1-nonen-3-one hydrochloride and related compounds on respiration in rat liver mitochondria.
Journal of pharmaceutical sciences 1982;71(1):25-9.