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Jonathan Dimmock

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Das Swagatika; Das Umashankar; Selvakumar Ponniah; Sharma Rajendra K; Balzarini Jan; De Clercq Erik; Molnár Joseph; Serly Julianna; Baráth Zoltán; Schatte Gabriele; Bandy Brian; Gorecki Dennis K J; Dimmock Jonathan R
3,5-Bis(benzylidene)-4-oxo-1-phosphonopiperidines and related diethyl esters: Potent cytotoxins with multi-drug-resistance reverting properties.
Das Umashankar; Pati Hari N; Panda Atulya K; De Clercq Erik; Balzarini Jan; Molnár Joseph; Baráth Zoltán; Ocsovszki Imre; Kawase Masami; Zhou Li; Sakagami Hiroshi; Dimmock Jonathan R
2-(3-Aryl-2-propenoyl)-3-methylquinoxaline-1,4-dioxides: a novel cluster of tumor-specific cytotoxins which reverse multidrug resistance.
Pati Hari N; Das Umashankar; Das Swagatika; Bandy Brian; De Clercq Erik; Balzarini Jan; Kawase Masami; Sakagami Hiroshi; Quail J Wilson; Stables James P; Dimmock Jonathan R
The cytotoxic properties and preferential toxicity to tumour cells displayed by some 2,4-bis(benzylidene)-8-methyl-8-azabicyclo[3.2.1] octan-3-ones and 3,5-bis(benzylidene)-1-methyl-4-piperidones.

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All Publications

2009: Das Swagatika; Das Umashankar; Selvakumar Ponniah; Sharma Rajendra K; Balzarini Jan; De Clercq Erik; Molnár Joseph; Serly Julianna; Baráth Zoltán; Schatte Gabriele; Bandy Brian; Gorecki Dennis K J; Dimmock Jonathan R
3,5-Bis(benzylidene)-4-oxo-1-phosphonopiperidines and related diethyl esters: Potent cytotoxins with multi-drug-resistance reverting properties.
ChemMedChem 2009;4(11):1831-40.
2009: Das Umashankar; Pati Hari N; Panda Atulya K; De Clercq Erik; Balzarini Jan; Molnár Joseph; Baráth Zoltán; Ocsovszki Imre; Kawase Masami; Zhou Li; Sakagami Hiroshi; Dimmock Jonathan R
2-(3-Aryl-2-propenoyl)-3-methylquinoxaline-1,4-dioxides: a novel cluster of tumor-specific cytotoxins which reverse multidrug resistance.
Bioorganic & medicinal chemistry 2009;17(11):3909-15.
2009: Pati Hari N; Das Umashankar; Das Swagatika; Bandy Brian; De Clercq Erik; Balzarini Jan; Kawase Masami; Sakagami Hiroshi; Quail J Wilson; Stables James P; Dimmock Jonathan R
The cytotoxic properties and preferential toxicity to tumour cells displayed by some 2,4-bis(benzylidene)-8-methyl-8-azabicyclo[3.2.1] octan-3-ones and 3,5-bis(benzylidene)-1-methyl-4-piperidones.
European journal of medicinal chemistry 2009;44(1):54-62.
2009: Selvakumar Ponniah; Lakshmikuttyamma Ashakumary; Das Umashankar; Pati Hari N; Dimmock Jonathan R; Sharma Rajendra K
NC2213: a novel methionine aminopeptidase 2 inhibitor in human colon cancer HT29 cells.
Molecular cancer 2009;8():65.
2009: Das U; Sharma R K; Dimmock J R
1,5-diaryl-3-oxo-1,4-pentadienes: a case for antineoplastics with multiple targets.
Current medicinal chemistry 2009;16(16):2001-20.
2008: Gul Halise Inci; Yerdelen Kadir Ozden; Das Umashankar; Gul Mustafa; Pandit Bulbul; Li Pui-Kai; Dimmock Jonathan Richard
Synthesis and cytotoxicity of novel 3-aryl-1-(3'-dibenzylaminomethyl-4'-hydroxyphenyl)-propenones and related compounds.
Chemical & pharmaceutical bulletin 2008;56(12):1675-81.
2008: Davis Ryan; Das Umashankar; Mackay Hilary; Brown Toni; Mooberry Susan L; Dimmock Jonathan R; Lee Moses; Pati Hari
Syntheses and cytotoxic properties of the curcumin analogs 2,6-bis(benzylidene)-4-phenylcyclohexanones.
Archiv der Pharmazie 2008;341(7):440-5.
2008: Das Umashankar; Molnár Joseph; Baráth Zoltán; Bata Zsuzsanna; Dimmock Jonathan R
1-[4-(2-Aminoethoxy)phenylcarbonyl]-3,5-bis-(benzylidene)-4-oxopiperidines: a novel series of highly potent revertants of P-glycoprotein associated multidrug resistance.
Bioorganic & medicinal chemistry letters 2008;18(12):3484-7.
2008: Das Umashankar; Doroudi Alireza; Das Swagatika; Bandy Brian; Balzarini Jan; De Clercq Erik; Dimmock Jonathan R
E,E-2-Benzylidene-6-(nitrobenzylidene)cyclohexanones: syntheses, cytotoxicity and an examination of some of their electronic, steric, and hydrophobic properties.
Bioorganic & medicinal chemistry 2008;16(11):6261-8.
2008: Pati Hari N; Das Umashankar; Kawase Masami; Sakagami Hiroshi; Balzarini Jan; De Clercq Erik; Dimmock Jonathan R
1-Aryl-2-dimethylaminomethyl-2-propen-1-one hydrochlorides and related adducts: A quest for selective cytotoxicity for malignant cells.
Bioorganic & medicinal chemistry 2008;16(10):5747-53.
2008: Das Umashankar; Das Swagatika; Bandy Brian; Stables James P; Dimmock Jonathan R
N-Aroyl-3,5-bis(benzylidene)-4-piperidones: a novel class of antimycobacterial agents.
Bioorganic & medicinal chemistry 2008;16(7):3602-7.
2008: Perjési Pal; Das Umashankar; De Clercq Erik; Balzarini Jan; Kawase Masame; Sakagami Hiroshi; Stables James P; Lorand Tamas; Rozmer Zsuzsanna; Dimmock Jonathan R
Design, synthesis and antiproliferative activity of some 3-benzylidene-2,3-dihydro-1-benzopyran-4-ones which display selective toxicity for malignant cells.
European journal of medicinal chemistry 2008;43(4):839-45.
2008: Pati Hari N; Das Umashankar; Quail J Wilson; Kawase Masami; Sakagami Hiroshi; Dimmock Jonathan R
Cytotoxic 3,5-bis(benzylidene)piperidin-4-ones and N-acyl analogs displaying selective toxicity for malignant cells.
European journal of medicinal chemistry 2008;43(1):1-7.
2007: Jha Amitabh; Mukherjee Chandrani; Prasad Ashok K; Parmar Virinder S; Clercq Erik De; Balzarini Jan; Stables James P; Manavathu Elias K; Shrivastav Anuraag; Sharma Rajendra K; Nienaber Kurt H; Zello Gordon A; Dimmock Jonathan R
E,E,E-1-(4-Arylamino-4-oxo-2-butenoyl)-3,5-bis(arylidene)-4-piperidones: a topographical study of some novel potent cytotoxins.
Bioorganic & medicinal chemistry 2007;15(17):5854-65.
2007: Das Umashankar; Selvakumar Ponniah; Sharma Rajendra K; Haas Thomas A; Dimmock Jonathan R
N-acyl-3,5-bis(arylidene)-4-piperidones and related compounds which stimulate fyn kinase.
Journal of enzyme inhibition and medicinal chemistry 2007;22(4):451-5.
2007: Das Umashankar; Kawase Masami; Sakagami Hiroshi; Ideo Atsushi; Shimada Jun; Molnár Joseph; Baráth Zoltán; Bata Zsuzsanna; Dimmock Jonathan R
3-(3,4,5-Trimethoxyphenyl)-1-oxo-2-propene: a novel pharmacophore displaying potent multidrug resistance reversal and selective cytotoxicity.
Bioorganic & medicinal chemistry 2007;15(10):3373-80.
2007: Pati Hari Narayan; Das Umashankar; Ramirez-Erosa Irving Javier; Dunlop Donna Mae; Hickie Robert Allan; Dimmock Jonathan Richard
Alpha-substituted 1-aryl-3-dimethylaminopropanone hydrochlorides: potent cytotoxins towards human WiDr colon cancer cells.
Chemical & pharmaceutical bulletin 2007;55(4):511-5.
2007: Pati Hari N; Das Umashankar; De Clercq Erik; Balzarini Jan; Dimmock Jonathan R
Molecular modifications of 2-arylidene-1-indanones leading to increased cytotoxic potencies.
Journal of enzyme inhibition and medicinal chemistry 2007;22(1):37-42.
2007: Pati Hari N; Das Umashankar; Sharma Rajendra K; Dimmock Jonathan R
Cytotoxic thiol alkylators.
Mini reviews in medicinal chemistry 2007;7(2):131-9.
2007: Das Umashankar; Alcorn Jane; Shrivastav Anuraag; Sharma Rajendra K; De Clercq Erik; Balzarini Jan; Dimmock Jonathan R
Design, synthesis and cytotoxic properties of novel 1-[4-(2-alkylaminoethoxy)phenylcarbonyl]-3,5-bis(arylidene)-4-piperidones and related compounds.
European journal of medicinal chemistry 2007;42(1):71-80.
2007: Selvakumar Ponniah; Lakshmikuttyamma Ashakumary; Shrivastav Anuraag; Das Shankar B; Dimmock Jonathan R; Sharma Rajendra K
Potential role of N-myristoyltransferase in cancer.
Progress in lipid research 2007;46(1):1-36.
2006: Shrivastav Anuraag; Singh Nand K; Tripathi Pratibha; George Theresa; Dimmock Jonathan R; Sharma Rajendra K
Copper(II) and manganese(III) complexes of N'-[(2-hydroxy phenyl) carbonothioyl] pyridine-2-carbohydrazide: novel therapeutic agents for cancer.
Biochimie 2006;88(9):1209-16.
2006: Jha A; Dimmock J R
1-N-(Arylmaleamoyl)-3,5-bis(phenylmethylene)4-piperidones: a novel class of antimycobacterial agents.
Die Pharmazie 2006;61(6):562-3.
2006: Das Umashankar; Gul H Inci; Alcorn Jane; Shrivastav Anuraag; George Theresa; Sharma Rajendra K; Nienaber Kurt H; De Clercq Erik; Balzarini Jan; Kawase Masami; Kan Noriyuki; Tanaka Toru; Tani Satoru; Werbovetz Karl A; Yakovich Adam J; Manavathu Elias K; Stables James P; Dimmock Jonathan R
Cytotoxic 5-aryl-1-(4-nitrophenyl)-3-oxo-1,4-pentadienes mounted on alicyclic scaffolds.
European journal of medicinal chemistry 2006;41(5):577-85.
2006: Selvakumar Ponniah; Lakshmikuttyamma Ashakumary; Dimmock Jonathan R; Sharma Rajendra K
Methionine aminopeptidase 2 and cancer.
Biochimica et biophysica acta 2006;1765(2):148-54.
2005: Stepkowski Stanislaw M; Kao Judy; Wang Mou-Er; Tejpal Neelam; Podder Hemangshu; Furian Lucrezia; Dimmock Jonathan; Jha Amitabh; Das Umashankar; Kahan Barry D; Kirken Robert A
The Mannich base NC1153 promotes long-term allograft survival and spares the recipient from multiple toxicities.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(7):4236-46.
2005: Dimmock Jonathan R; Das Umashankar; Gul H Inci; Kawase Masami; Sakagami Hiroshi; Baráth Zoltán; Ocsovsky Imre; Molnár Joseph
3-Arylidene-1-(4-nitrophenylmethylene)-3,4-dihydro-1H-naphthalen-2-ones and related compounds displaying selective toxicity and reversal of multidrug resistance in neoplastic cells.
Bioorganic & medicinal chemistry letters 2005;15(6):1633-6.
2005: Shrivastav Anuraag; Selvakumar Ponniah; Bajaj Gagan; Lu Yanjie; Dimmock Jonathan R; Sharma Rajendra K
Regulation of N-myristoyltransferase by novel inhibitor proteins.
Cell biochemistry and biophysics 2005;43(1):189-202.
2004: Selvakumar Ponniah; Lakshmikuttyamma Ashakumary; Lawman Zoe; Bonham Keith; Dimmock Jonathan R; Sharma Rajendra K
Expression of methionine aminopeptidase 2, N-myristoyltransferase, and N-myristoyltransferase inhibitor protein 71 in HT29.
Biochemical and biophysical research communications 2004;322(3):1012-7.
2004: Dimmock J R; Gunda S G R; Vashishtha S C; Zello G A; Das U; Nienaber K H; Stables J P; Allen T M; Santos C L
Anticonvulsants containing the N-(3-aryl-2-propenoyl) amido pharmacophore.
Journal of enzyme inhibition and medicinal chemistry 2004;19(4):303-12.
2004: Dimmock J R; Kandepu N M; Das U; Zello G A; Nienaber K H
Antimycobacterial arylidenecyclohexanones and related Mannich bases.
Die Pharmazie 2004;59(7):502-5.
2004: Selvakumar Ponniah; Lakshmikuttyamma Ashakumary; Pasha Mohammed Khysar; King Martin J; Olson Douglas J H; Mori Sumiko; Ross Andrew R S; Hayashi Kiyoshi; Dimmock Jonathan R; Sharma Rajendra K
N-myristoyltransferase inhibitor protein is homologous to heat shock cognate protein 70.
Journal of cellular biochemistry 2004;92(3):573-8.
2004: Selvakumar Ponniah; Lakshmikuttyamma Ashakumary; Kanthan Rani; Kanthan Selliah Chandra; Dimmock Jonathan R; Sharma Rajendra K
High expression of methionine aminopeptidase 2 in human colorectal adenocarcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(8):2771-5.
2004: Pasha Mohammed Khysar; Selvakumar Ponniah; Ashakumary Lakshmikuttyamma; Qureshi Mabood; Guziec Frank S; Dimmock Jonathan R; Felsted Ronald L; Glover Constance J; Sharma Rajendra K
Lipidic inhibitors of human N-myristoyltransferase.
International journal of molecular medicine 2004;13(4):557-63.
2004: Dimmock J R; Chamankhah M; Das U; Zello G A; Quail J W; Yang J; Nienaber K H; Sharma R K; Selvakumar P; Balzarini J; De Clercq E; Stables J P
Cytotoxic and topographical properties of 6-arylidene-2-dimethylaminomethylcyclohexanone hydrochlorides and related compounds.
Journal of enzyme inhibition and medicinal chemistry 2004;19(1):1-10.
2004: Gowda Sweta; Shrivastav Anuraag; Selvakumar Ponniah; Dimmock Jonathan R; Sharma Rajendra K
A novel inhibitor protein of N-myristoyltransferase from Escherichia coli.
Biochemical and biophysical research communications 2004;314(4):984-7.
2004: Vashishtha Sarvesh C; Zello Gordon A; Nienaber Kurt H; Balzarini Jan; De Clercq Erik; Stables James P; Dimmock Jonathan R
Cytotoxic and anticonvulsant aryloxyaryl Mannich bases and related compounds.
European journal of medicinal chemistry 2004;39(1):27-35.
2003: Shrivastav Anuraag; Pasha Mohammed K; Selvakumar Ponniah; Gowda Sweta; Olson Douglas J H; Ross Andrew R S; Dimmock Jonathan R; Sharma Rajendra K
Potent inhibitor of N-myristoylation: a novel molecular target for cancer.
Cancer research 2003;63(22):7975-8.
2003: Dimmock J R; Jha A; Zello G A; Sharma R K; Shrivastav A; Selvakumar P; Allen T M; Santos C L; Balzarini J; De Clercq E; Manavathu E K; Stables J P
3,5-bis(phenylmethylene)-1-(N-arylmaleamoyl)-4-piperidones: a novel group of cytotoxic agents.
Journal of enzyme inhibition and medicinal chemistry 2003;18(4):325-32.
2003: Dimmock J R; Padmanilayam M P; Das U; Zello G A; Sharma R K; Shrivastav A; Selvakumar P; Pasha M K; Nienaber K H; Lee J S; Allen T M; Santos C L; Balzarini J; De Clercq E
Cytotoxic mannich bases of 1-arylidene-2-tetralones.
Journal of enzyme inhibition and medicinal chemistry 2003;18(4):313-24.
2003: Dimmock J R; Jha A; Zello G A; Allen T M; Santos C L; Balzarini J; De Clercq E; Manavathu E K; Stables J P
Cytotoxic 4'-aminochalcones and related compounds.
Die Pharmazie 2003;58(4):227-32.
2003: Dimmock J R; Zello G A; Vashishtha S C; Hayes S J; Mutalik S; Kumar S; Venkatesh M; Udupa N
A toxicological evaluation of 2-dimethylaminomethyl-1-phenyl-2-propen-1-one hydrochloride.
Die Pharmazie 2003;58(2):136-9.
2003: Dimmock Jonathan R; Padmanilayam Maniyan P; Zello Gordon A; Nienaber Kurt H; Allen Theresa M; Santos Cheryl L; De Clercq Erik; Balzarini Jan; Manavathu Elias K; Stables James P
Cytotoxic analogues of 2,6-bis(arylidene)cyclohexanones.
European journal of medicinal chemistry 2003;38(2):169-77.
2002: Dimmock Jonathan R; Jha Amitabh; Zello Gordon A; Quail J Wilson; Oloo Eliud O; Nienaber Kurt H; Kowalczyk Earl S; Allen Theresa M; Santos Cheryl L; De Clercq Erik; Balzarini Jan; Manavathu Elias K; Stables James P
Cytotoxic N-[4-(3-aryl-3-oxo-1-propenyl)phenylcarbonyl]-3,5-bis(phenylmethylene)-4-piperidones and related compounds.
European journal of medicinal chemistry 2002;37(12):961-72.
2002: Pasha Mohammed Khysar; Dimmock Jonathan R; Hollenberg Morley D; Sharma Rajendra K
Enhanced activity of human N-myristoyltransferase by dimethyl sulfoxide and related solvents in the presence of serine/threonine-containing peptide substrates.
Biochemical pharmacology 2002;64(10):1461-7.
2002: Dimmock Jonathan R; Padmanilyam Maniyan P; Zello Gordon A; Quail J Wilson; Oloo Eliud O; Prisciak Jared S; Kraatz Heinz Bernhard; Cherkasov Arten; Lee Jeremy S; Allen Theresa M; Santos Cheryl L; Manavathu Elias K; De Clercq Erik; Balzarini Jan; Stables James P
Cytotoxic 1,3-diarylidene-2-tetralones and related compounds.
European journal of medicinal chemistry 2002;37(10):813-24.
2002: Selvakumar Ponniah; Pasha Mohammed Khysar; Ashakumary Lakshmikuttyamma; Dimmock Jonathan R; Sharma Rajendra K
Myristoyl-CoA:protein N-myristoyltransferase: a novel molecular approach for cancer therapy (Review).
International journal of molecular medicine 2002;10(4):493-500.
2002: Dimmock Jonathan R; Zello Gordon A; Oloo Eliud O; Quail J Wilson; Kraatz Heinz-Bernhard; Perjési Pál; Aradi Ferenc; Takács-Novák Krisztina; Allen Theresa M; Santos Cheryl L; Balzarini Jan; De Clercq Erik; Stables James P
Correlations between cytotoxicity and topography of some 2-arylidenebenzocycloalkanones determined by X-ray crystallography.
Journal of medicinal chemistry 2002;45(14):3103-11.
2002: Dimmock Jonathan R; Jha Amitabh; Kumar Praveen; Zello Gordon A; Quail J Wilson; Oloo Eliud O; Oucharek Jennifer J; Pasha Mohammed K; Seitz Dallas; Sharma Rajendra K; Allen Theresa M; Santos Cheryl L; Manavathu Elias K; De Clercq Erik; Balzarini Jan; Stables James P
Cytotoxic 1,4-bis(2-oxo-1-cycloalkylmethylene)benzenes and related compounds.
European journal of medicinal chemistry 2002;37(1):35-44.
2001: Dimmock J R; Kumar P; Jha A; Quail J W
Synthesis and cytotoxicity of 1-phenyl-3,3-diacetoxy-1-propene.
Die Pharmazie 2001;56(9):744-5.
2001: Vashishtha S C; Allen T M; Halleran S; Szydlowski J; Santos C L; De Clercq E; Balzarani J; Dimmock J R
Cytotoxic and anticancer properties of some 4-aryl-3-arylcarbonyl-1-ethyl-4-piperidinols and related compounds.
Die Pharmazie 2001;56(5):390-3.
2001: Manavathu E K; Dimmock J R; Vashishtha S C; Chandrasekar P H
Inhibition of H(+)-ATPase-mediated proton pumping in Cryptococcus neoformans by a novel conjugated styryl ketone.
The Journal of antimicrobial chemotherapy 2001;47(4):491-4.
2001: Dimmock J R; Padmanilayam M P; Puthucode R N; Nazarali A J; Motaganahalli N L; Zello G A; Quail J W; Oloo E O; Kraatz H B; Prisciak J S; Allen T M; Santos C L; Balzarini J; De Clercq E; Manavathu E K
A conformational and structure-activity relationship study of cytotoxic 3,5-bis(arylidene)-4-piperidones and related N-acryloyl analogues.
Journal of medicinal chemistry 2001;44(4):586-93.
2000: Dimmock J R; Kumar P; Nazarali A J; Motaganahalli N L; Kowalchuk T P; Beazely M A; Wilson Quail J; Oloo E O; Allen T M; Szydlowski J; DeClercq E; Balzarini J
Cytotoxic 2,6-bis(arylidene)cyclohexanones and related compounds.
European journal of medicinal chemistry 2000;35(11):967-77.
2000: Dimmock J R; Kandepu N M; Nazarali A J; Motaganahalli N L; Kowalchuk T P; Pugazhenthi U; Prisciak J S; Quail J W; Allen T M; LeClerc R; Santos C L; De Clercq E; Balzarini J
Sequential cytotoxicity: a theory evaluated using novel 2-[4-(3-aryl-2-propenoyloxy)phenylmethylene]cyclohexanones and related compounds.
Journal of medicinal chemistry 2000;43(21):3933-40.
2000: Dimmock J R; Vashishtha S C; Stables J P
Ureylene anticonvulsants and related compounds.
Die Pharmazie 2000;55(7):490-4.
2000: Dimmock J R; Vashishtha S C; Stables J P
Anticonvulsant properties of various acetylhydrazones, oxamoylhydrazones and semicarbazones derived from aromatic and unsaturated carbonyl compounds.
European journal of medicinal chemistry 2000;35(2):241-8.
1999: Manavathu E K; Dimmock J R; Vashishtha S C; Chandrasekar P H
Proton-pumping-ATPase-targeted antifungal activity of a novel conjugated styryl ketone.
Antimicrobial agents and chemotherapy 1999;43(12):2950-9.
1999: Dimmock J R; Elias D W; Beazely M A; Kandepu N M
Bioactivities of chalcones.
Current medicinal chemistry 1999;6(12):1125-49.
1999: Dimmock J R; Semple H A; John S; Beazely M A; Abrams G D
Isolation and identification of the major urinary metabolite of 4-(4-fluorophenoxy)benzaldehyde semicarbazone after oral dosing to rats.
Die Pharmazie 1999;54(4):260-2.
1999: Dimmock J R; Kandepu N M; Nazarali A J; Kowalchuk T P; Motaganahalli N; Quail J W; Mykytiuk P A; Audette G F; Prasad L; Perjési P; Allen T M; Santos C L; Szydlowski J; De Clercq E; Balzarini J
Conformational and quantitative structure-activity relationship study of cytotoxic 2-arylidenebenzocycloalkanones.
Journal of medicinal chemistry 1999;42(8):1358-66.
1998: Manavathu E K; Dimmock J R; Vashishtha S C; Cutright J; Chandrasekar P H
In-vitro and in-vivo susceptibility of Aspergillus fumigatus to a novel conjugated styryl ketone.
The Journal of antimicrobial chemotherapy 1998;42(5):585-90.
1998: Dimmock J R; Vashishtha S C; Patil S A; Udupa N; Dinesh S B; Devi P U; Kamath R
Cytotoxic and anticancer activities of some 1-aryl-2-dimethylaminomethyl-2-propen-1-one hydrochlorides.
Die Pharmazie 1998;53(10):702-6.
1998: Dimmock J R; Vashishtha S C; Quail J W; Pugazhenthi U; Zimpel Z; Sudom A M; Allen T M; Kao G Y; Balzarini J; De Clercq E
4-(beta-Arylvinyl)-3-(beta-arylvinylketo)-1-ethyl-4-piperidinols and related compounds: a novel class of cytotoxic and anticancer agents.
Journal of medicinal chemistry 1998;41(21):4012-20.
1998: Vashishtha S C; Nazarali A J; Dimmock J R
Application of fluorescence microscopy to measure apoptosis in Jurkat T cells after treatment with a new investigational anticancer agent (N.C.1213).
Cellular and molecular neurobiology 1998;18(4):437-45.
1998: Vashishtha S C; Dimmock J R; Manavathu E K
Antifungal activity of some quaternary ammonium salts of 4-(2-arylvinyl)-3-(3-aryl-2-propenoyl)-1-ethyl-4-piperidinols and related compounds.
Die Pharmazie 1998;53(7):499-500.
1998: Dimmock J R; Pandeya S N; Allen T M; Kao G Y
Mannich bases of arylalicyclic ketones and related quaternary ammonium compounds with antileukemic properties.
Die Pharmazie 1998;53(3):201-2.
1998: Dimmock J R; Kandepu N M; Hetherington M; Quail J W; Pugazhenthi U; Sudom A M; Chamankhah M; Rose P; Pass E; Allen T M; Halleran S; Szydlowski J; Mutus B; Tannous M; Manavathu E K; Myers T G; De Clercq E; Balzarini J
Cytotoxic activities of Mannich bases of chalcones and related compounds.
Journal of medicinal chemistry 1998;41(7):1014-26.
1998: Manavathu E K; Vashishtha S C; Alangaden G J; Dimmock J R
In vitro antifungal activity of some Mannich bases of conjugated styryl ketones.
Canadian journal of microbiology 1998;44(1):74-9.
1997: Dimmock J R; Kumar P; Allen T M; Kao G Y; Halleran S; Balzarini J; de Clercq E
Synthesis and cytotoxic evaluation of some carbohydrazones and thiocarbohydrazones of various unsaturated ketones and related Mannich bases.
Die Pharmazie 1997;52(3):182-6.
1996: Dimmock J R; Puthucode R N; Smith J M; Hetherington M; Quail J W; Pugazhenthi U; Lechler T; Stables J P
(Aryloxy)aryl semicarbazones and related compounds: a novel class of anticonvulsant agents possessing high activity in the maximal electroshock screen.
Journal of medicinal chemistry 1996;39(20):3984-97.
1996: Dimmock J R; Puthucode R N; Lo M S; Quail J W; Yang J; Stables J P
Structural modifications of the primary amino group of anticonvulsant aryl semicarbazones.
Die Pharmazie 1996;51(2):83-8.
1995: Dimmock J R; Vashishtha S C; Stables J P
Anticonvulsant semicarbazones: are aryl groups necessary for activity?
Die Pharmazie 1995;50(12):823-4.
1995: Dimmock J R; Chamankhah M; Seniuk A; Allen T M; Kao G Y; Halleran S
Synthesis and cytotoxic evaluation of some Mannich bases of alicyclic ketones.
Die Pharmazie 1995;50(10):668-71.
1995: Dimmock J R; Kumar P; Chen M; Quail J W; Yang J; Allen T M; Kao G Y
Synthesis and cytotoxic evaluation of mesna adducts of some 1-aryl-4,4-dimethyl-5-(1-piperidino)-1-penten-3-one hydrochlorides.
Die Pharmazie 1995;50(7):449-53.
1995: Dimmock J R; Chamankhah M; Allen T M; Hallran S
Mannich bases of 2-arylmethylenecyclohexanone with cytotoxic activity.
Die Pharmazie 1995;50(3):221-2.
1994: Dimmock J R; Kumar P; Manavathu E K; Obedeanu N; Grewal J
Activity of some Mannich bases of conjugated styryl ketones against Candida albicans.
Die Pharmazie 1994;49(12):909-12.
1994: Dimmock J R; Arora V K; Quail J W; Pugazhenthi U; Allen T M; Kao G Y; De Clercq E
Cytotoxic evaluation of some 3,5-diarylidene-4-piperidones and various related quaternary ammonium compounds and analogs.
Journal of pharmaceutical sciences 1994;83(8):1124-30.
1994: Dimmock J R; Arora V K; Chen M; Allen T M; Kao G Y
Cytotoxic evaluation of some N-acyl and N-acyloxy analogues of 3,5-bis(arylidene)-4-piperidones.
Drug design and discovery 1994;12(1):19-28.
1994: Dimmock J R; Sidhu K K; Chen M; Li J; Quail J W; Allen T M; Kao G Y
Synthesis and cytotoxic evaluation of some cyclic arylidene ketones and related oximes, oxime esters, and analogs.
Journal of pharmaceutical sciences 1994;83(6):852-8.
1994: Dimmock J R; Baker G B
Anticonvulsant activities of 4-bromobenzaldehyde semicarbazone.
Epilepsia 1994;35(3):648-55.
1993: Pandeya S N; Dimmock J R
Recent evaluations of thiosemicarbazones and semicarbazones and related compounds for antineoplastic and anticonvulsant activities.
Die Pharmazie 1993;48(9):659-66.
1993: Dimmock J R; Sidhu K K; Thayer R S; Mack P; Duffy M J; Reid R S; Quail J W; Pugazhenthi U; Ong A; Bikker J A
Anticonvulsant activities of some arylsemicarbazones displaying potent oral activity in the maximal electroshock screen in rats accompanied by high protection indices.
Journal of medicinal chemistry 1993;36(16):2243-52.
1993: Sexton D J; Dimmock J R; Mutus B
A spectrophotometric glutathione S-transferase assay displaying alpha-class selectivity utilizing 1-p-chlorophenyl-4,4-dimethyl-5-diethylamino-1-penten-3- one hydrobromide.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1993;71(1-2):98-101.
1992: Dimmock J R; Advikolanu K M; Scott H E; Duffy M J; Reid R S; Quail J W; Jia Z; Hickie R A; Allen T M; Rutledge J M
Evaluation of cytotoxicity of some Mannich bases of various aryl and arylidene ketones and their corresponding arylhydrazones.
Journal of pharmaceutical sciences 1992;81(12):1147-52.
1992: Dimmock J R; Sidhu K K; Quail J W; Jia Z; Duffy M J; Reid R S; Kirkpatrick D L; Zhu L; Fletcher S M
Synthesis and cytotoxic evaluation of some 6-arylidene-2-(alpha-hydroxyamino-alpha-arylmethyl)cyclohexanone oximes and related compounds.
Journal of pharmaceutical sciences 1992;81(11):1059-64.
1992: Dimmock J R; Arora V K; Duffy M J; Reid R S; Allen T M; Kao G Y
Evaluation of some N-acyl analogues of 3,5-bis(arylidene)-4-piperidones for cytotoxic activity.
Drug design and discovery 1992;8(4):291-9.
1992: Dimmock J R; Jonnalagadda S S; Phillips O A; Erciyas E; Shyam K; Semple H A
Anticonvulsant properties of some Mannich bases of conjugated arylidene ketones.
Journal of pharmaceutical sciences 1992;81(5):436-40.
1992: Dimmock J R; Arora V K; Semple H A; Lee J S; Allen T M; Kao G Y
3,5-Bis-arylidene-1-methyl-4-piperidone methohalides and related compounds with activity against L 1210 cells and DNA binding properties.
Die Pharmazie 1992;47(4):246-8.
1991: Dimmock J R; Patil S A; Shyam K
Evaluation of some Mannich bases of 1-aryl-1-ethanones and related ketones for anticonvulsant activities.
Die Pharmazie 1991;46(7):538-9.
1991: Thomas D; Klein K; Manavathu E; Dimmock J R; Mutus B
Glutathione levels during thermal induction of the yeast-to-mycelial transition in Candida albicans.
FEMS microbiology letters 1991;61(2-3):331-4.
1990: Dimmock J R; Erciyas E; Bigam G E; Kirkpatrick D L; Duke M M
Cytotoxicity of Mannich bases of alpha-arylidene-beta-ketoesters and related compounds against EMT6 mammary carcinoma cells.
Drug design and delivery 1990;7(1):51-8.
1990: Dimmock J R; Erciyas E; Sidhu K K; Luo X; Mezey P G; Allen T M; Murray L
Charge densities of atoms of conjugated styryl ketones having activity against L1210 leukemia cells.
Drug design and delivery 1990;7(1):45-9.
1990: Dimmock J R; Erciyas E; Raghavan S K; Kirkpatrick D L
Evaluation of the cytotoxicity of some Mannich bases of acetophenone against the EMT6 tumour.
Die Pharmazie 1990;45(10):755-7.
1990: Dimmock J R; Arora V K; Wonko S L; Hamon N W; Quail J W; Jia Z; Warrington R C; Fang W D; Lee J S
3,5-Bis-benzylidene-4-piperidones and related compounds with high activity towards P388 leukemia cells.
Drug design and delivery 1990;6(3):183-94.
1990: Rousseaux C G; Townsend H G; Phillips O A; Dimmock J R
Toxicologic studies on a novel antineoplastic bis-Mannich base, derived from a conjugated styryl ketone.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1990;14(2):318-26.
1989: Dimmock J R; Hamon N W; De Gooijer C A; Grant G F; Jonnalagadda S S; Hancock D S
Effect of some 4-alkyl-5-dimethylamino-1-phenyl-1-penten-3-one hydrochlorides and related compounds on respiration in mouse liver mitochondria.
Die Pharmazie 1989;44(8):560-2.
1989: Mutus B; Wagner J D; Talpas C J; Dimmock J R; Phillips O A; Reid R S
1-p-chlorophenyl-4,4-dimethyl-5-diethylamino-1-penten-3-one hydrobromide, a sulfhydryl-specific compound which reacts irreversibly with protein thiols but reversibly with small molecular weight thiols.
Analytical biochemistry 1989;177(2):237-43.
1988: Dimmock J R; Erciyas E; Kirkpatrick D L; King K M
Evaluation of some azines of aminomethylacetophenones and related quaternary ammonium compounds versus the EMT6 tumour.
Die Pharmazie 1988;43(9):614-6.
1988: Dimmock J R; Jonnalagadda S S; Leek D M; Warrington R C; Fang W D
Evaluation of Mannich bases of styryl ketones and related hydrazones for activity against P388 leukemia.
Neoplasma 1988;35(6):715-24.
1987: Dimmock J R; Brenner J M; Phillips O A
Evaluation of some benzenesulphonylhydrazones of aryl aldehydes and ketones as antiepileptic agents.
Die Pharmazie 1987;42(6):376-8.
1986: Dimmock J R; Hamon N W; Waslen T A; Patil S A; Phillips O A; Jonnalagadda S S; Hancock D S
Effect of some Mannich bases derived from aryl-alpha, beta-unsaturated ketones on respiration in mouse liver mitochondria.
Die Pharmazie 1986;41(6):441-2.
1986: Dimmock J R; Patil S A
A retro-Mannich reaction of a bis-Mannich base.
Die Pharmazie 1986;41(4):284.
1985: Dimmock J R; Shyam K; Hamon N W; Patil S A; Smith P J
bis-Mannich bases of styryl ketones as antileukemic agents.
Neoplasma 1985;32(1):85-91.
1984: Dimmock J R; Shyam K; Smith P J
Decomposition of 1-aryl-3-dimethylamino-1-propanone methobromides under weakly acidic conditions.
Die Pharmazie 1984;39(7):467-70.
1984: Dimmock J R; Shyam K; Logan B M; Smith P J; Cross B M
Syntheses and evaluation of some mannich bases derived from acetophenones against P388 lymphocytic leukemia and toxicological assessment of 3-dimethyl-amino-2-dimethylaminomethyl-1-(4-methoxyphenyl)-1-propanone dihydrochloride in rats.
Journal of pharmaceutical sciences 1984;73(4):471-7.
1983: Dimmock J R; Shyam K; Hamon N W; Logan B M; Raghavan S K; Harwood D J; Smith P J
Evaluation of some Mannich bases derived from substituted acetophenones against P-388 lymphocytic leukemia and on respiration in isolated rat liver mitochondria.
Journal of pharmaceutical sciences 1983;72(8):887-94.
1982: Dimmock J R; Kirkpatrick D L; Webb N G; Cross B M
Synthesis and evaluation of some alkoxy-, chloro-, and acyloxy-conjugated styryl ketones against P-388 lymphocytic leukemia and an examination of the metabolism and toxicological effects of 1-(m-ethoxymethyloxyphenyl)-1-nonen-3-one in rats.
Journal of pharmaceutical sciences 1982;71(9):1000-7.
1982: Hamon N W; Kirkpatrick D L; Chow E W; Dimmock J R
Effect of 4-dimethylaminomethyl-1-(3-hydroxyphenyl)-1-nonen-3-one hydrochloride and related compounds on respiration in rat liver mitochondria.
Journal of pharmaceutical sciences 1982;71(1):25-9.

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