Charles Dinarello

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Inflammation

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Wang Meijing; Tan Jiangning; Wang Yue; Meldrum Kirstan K; Dinarello Charles A; Meldrum Daniel R
IL-18 binding protein-expressing mesenchymal stem cells improve myocardial protection after ischemia or infarction.
Carmi Yaron; Voronov Elena; Dotan Shahar; Lahat Nitza; Rahat Michal A; Fogel Mina; Huszar Monika; White Malka R; Dinarello Charles A; Apte Ron N
The role of macrophage-derived IL-1 in induction and maintenance of angiogenesis.
Lonnemann G; Bahlmann F H; Freise J; Hertel B; Dinarello C A
Low-flux hemodialysis suppresses interferon-gamma production: the possible role of beta2-microglobulin.

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All Publications

2009: Wang Meijing; Tan Jiangning; Wang Yue; Meldrum Kirstan K; Dinarello Charles A; Meldrum Daniel R
IL-18 binding protein-expressing mesenchymal stem cells improve myocardial protection after ischemia or infarction.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(41):17499-504.
2009: Carmi Yaron; Voronov Elena; Dotan Shahar; Lahat Nitza; Rahat Michal A; Fogel Mina; Huszar Monika; White Malka R; Dinarello Charles A; Apte Ron N
The role of macrophage-derived IL-1 in induction and maintenance of angiogenesis.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(7):4705-14.
2009: Lonnemann G; Bahlmann F H; Freise J; Hertel B; Dinarello C A
Low-flux hemodialysis suppresses interferon-gamma production: the possible role of beta2-microglobulin.
Clinical nephrology 2009;72(3):170-6.
2009: Favilli Flavia; Anzilotti Consuelo; Martinelli Lucia; Quattroni Paola; De Martino Salvatore; Pratesi Federico; Neumann Detlef; Beermann Silke; Novick Daniela; Dinarello Charles A; Boraschi Diana; Migliorini Paola
IL-18 activity in systemic lupus erythematosus.
Annals of the New York Academy of Sciences 2009;1173():301-9.
2009: Nold-Petry Claudia A; Nold Marcel F; Nielsen Jason W; Bustamante Alex; Zepp Jarod A; Storm Kathleen A; Hong Jae-Woo; Kim Soo-Hyun; Dinarello Charles A
Increased cytokine production in interleukin-18 receptor alpha-deficient cells is associated with dysregulation of suppressors of cytokine signaling.
The Journal of biological chemistry 2009;284(38):25900-11.
2009: Bani-Hani Ahmad H; Leslie Jeffery A; Asanuma Hiroshi; Dinarello Charles A; Campbell Matthew T; Meldrum Daniel R; Zhang Honji; Hile Karen; Meldrum Kirstan K
IL-18 neutralization ameliorates obstruction-induced epithelial-mesenchymal transition and renal fibrosis.
Kidney international 2009;76(5):500-11.
2009: Kliger Yossef; Levy Ofer; Oren Anat; Ashkenazy Haim; Tiran Zohar; Novik Amit; Rosenberg Avi; Amir Anat; Wool Assaf; Toporik Amir; Schreiber Ehud; Eshel Dani; Levine Zurit; Cohen Yossi; Nold-Petry Claudia; Dinarello Charles A; Borukhov Itamar
Peptides modulating conformational changes in secreted chaperones: from in silico design to preclinical proof of concept.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(33):13797-801.
2009: Kleinnijenhuis Johanneke; Joosten Leo A B; van de Veerdonk Frank L; Savage Nigel; van Crevel Reinout; Kullberg Bart Jan; van der Ven Andre; Ottenhoff Tom H M; Dinarello Charles A; van der Meer Jos W M; Netea Mihai G
Transcriptional and inflammasome-mediated pathways for the induction of IL-1beta production by Mycobacterium tuberculosis.
European journal of immunology 2009;39(7):1914-22.
2009: Dinarello Charles A
Interleukin-1beta and the autoinflammatory diseases.
The New England journal of medicine 2009;360(23):2467-70.
2009: van der Meer J H M; Netea M G; Dinarello C A
Modulation of muramyl dipeptide stimulation of cytokine production by blood components.
Clinical and experimental immunology 2009;156(3):428-33.
2009: Olson Jeffrey L; Courtney Robert J; Rouhani Behnaz; Mandava Naresh; Dinarello Charles A
Intravitreal anakinra inhibits choroidal neovascular membrane growth in a rat model.
Ocular immunology and inflammation 2009;17(3):195-200.
2009: Dinarello Charles A
Hyperosmolar sodium chloride, p38 mitogen activated protein and cytokine-mediated inflammation.
Seminars in dialysis 2009;22(3):256-9.
2009: Sun Yaping; Chin Y Eugene; Weisiger Elizabeth; Malter Chelsea; Tawara Isao; Toubai Tomomi; Gatza Erin; Mascagni Paolo; Dinarello Charles A; Reddy Pavan
Cutting edge: Negative regulation of dendritic cells through acetylation of the nonhistone protein STAT-3.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(10):5899-903.
2009: Pott Gregory B; Chan Edward D; Dinarello Charles A; Shapiro Leland
Alpha-1-antitrypsin is an endogenous inhibitor of proinflammatory cytokine production in whole blood.
Journal of leukocyte biology 2009;85(5):886-95.
2009: Ben-Sasson Shlomo Z; Hu-Li Jane; Quiel Juan; Cauchetaux Stephane; Ratner Maya; Shapira Ilana; Dinarello Charles A; Paul William E
IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(17):7119-24.
2009: Elkabets Moshe; Krelin Yakov; Dotan Shahar; Cerwenka Adelheid; Porgador Angel; Lichtenstein Rachel G; White Malka R; Zoller Margot; Iwakura Yoichizo; Dinarello Charles A; Voronov Elena; Apte Ron N
Host-derived interleukin-1alpha is important in determining the immunogenicity of 3-methylcholantrene tumor cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(8):4874-81.
2009: van de Veerdonk Frank L; Joosten Leo A B; Devesa Isabel; Mora-Montes Héctor M; Kanneganti Thirumala-Devi; Dinarello Charles A; van der Meer Jos W M; Gow Neil A R; Kullberg Bart Jan; Netea Mihai G
Bypassing pathogen-induced inflammasome activation for the regulation of interleukin-1beta production by the fungal pathogen Candida albicans.
The Journal of infectious diseases 2009;199(7):1087-96.
2009: Choi Ji-Da; Bae Su-Young; Hong Jae-Woo; Azam Tania; Dinarello Charles A; Her Erk; Choi Whan-Soo; Kim Bo-Kyung; Lee Chang-Kwon; Yoon Do-Young; Kim Sun-Jong; Kim Soo-Hyun
Identification of the most active interleukin-32 isoform.
Immunology 2009;126(4):535-42.
2009: Nold-Petry Claudia A; Nold Marcel F; Zepp Jarod A; Kim Soo-Hyun; Voelkel Norbert F; Dinarello Charles A
IL-32-dependent effects of IL-1beta on endothelial cell functions.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(10):3883-8.
2009: Netea Mihai G; Nold-Petry Claudia A; Nold Marcel F; Joosten Leo A B; Opitz Bastian; van der Meer Jonathan H M; van de Veerdonk Frank L; Ferwerda Gerben; Heinhuis Bas; Devesa Isabel; Funk C Joel; Mason Robert J; Kullberg Bart Jan; Rubartelli Anna; van der Meer Jos W M; Dinarello Charles A
Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages.
Blood 2009;113(10):2324-35.
2009: Dinarello Charles A
Targeting the pathogenic role of interleukin 1{beta} in the progression of smoldering/indolent myeloma to active disease.
Mayo Clinic proceedings. Mayo Clinic 2009;84(2):105-7.
2009: Dinarello Charles A
Inflammation in human disease: anticytokine therapy.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2009;15(1 Suppl):134-6.
2009: Arcaroli John J; Hokanson John E; Abraham Edward; Geraci Mark; Murphy James R; Bowler Russell P; Dinarello Charles A; Silveira Lori; Sankoff Jeff; Heyland Daren; Wischmeyer Paul; Crapo James D
Extracellular superoxide dismutase haplotypes are associated with acute lung injury and mortality.
American journal of respiratory and critical care medicine 2009;179(2):105-12.
2009: Novick D; Elbirt D; Dinarello C A; Rubinstein M; Sthoeger Z M
Interleukin-18 binding protein in the sera of patients with Wegener's granulomatosis.
Journal of clinical immunology 2009;29(1):38-45.
2009: Dinarello Charles A
Immunological and inflammatory functions of the interleukin-1 family.
Annual review of immunology 2009;27():519-50.
2008: Bosisio Daniela; Vulcano Marisa; Del Prete Annalisa; Sironi Marina; Salvi Valentina; Salogni Laura; Riboldi Elena; Leoni Flavio; Dinarello Charles A; Girolomoni Giampiero; Sozzani Silvano
Blocking TH17-polarizing cytokines by histone deacetylase inhibitors in vitro and in vivo.
Journal of leukocyte biology 2008;84(6):1540-8.
2008: Kim Sunjong; Lee Siyoung; Her Erk; Bae Suyoung; Choi Jida; Hong Jaewoo; Jaekal Jun; Yoon Doyoung; Azam Tania; Dinarello Charles A; Kim Soohyun
Proteinase 3-processed form of the recombinant IL-32 separate domain.
BMB reports 2008;41(11):814-9.
2008: He Zhibin; Lu Lawrence; Altmann Christopher; Hoke Thomas S; Ljubanovic Danica; Jani Alkesh; Dinarello Charles A; Faubel Sarah; Edelstein Charles L
Interleukin-18 binding protein transgenic mice are protected against ischemic acute kidney injury.
American journal of physiology. Renal physiology 2008;295(5):F1414-21.
2008: Calabrese Fiorella; Baraldo Simonetta; Bazzan Erica; Lunardi Francesca; Rea Federico; Maestrelli Piero; Turato Graziella; Lokar-Oliani Kim; Papi Alberto; Zuin Renzo; Sfriso Paolo; Balestro Elisabetta; Dinarello Charles A; Saetta Marina
IL-32, a novel proinflammatory cytokine in chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 2008;178(9):894-901.
2008: Lewis Eli C; Mizrahi Mark; Toledano Michel; Defelice Nathaniel; Wright Joanne L; Churg Andrew; Shapiro Leland; Dinarello Charles A
alpha1-Antitrypsin monotherapy induces immune tolerance during islet allograft transplantation in mice.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(42):16236-41.
2008: Botsios Costantino; Sfriso Paolo; Furlan Antonio; Punzi Leonardo; Dinarello Charles A
Resistant Behçet disease responsive to anakinra.
Annals of internal medicine 2008;149(4):284-6.
2008: Reddy Pavan; Sun Yaping; Toubai Tomomi; Duran-Struuck Raimon; Clouthier Shawn G; Weisiger Elizabeth; Maeda Yoshinobu; Tawara Isao; Krijanovski Oleg; Gatza Erin; Liu Chen; Malter Chelsea; Mascagni Paolo; Dinarello Charles A; Ferrara James L M
Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenase-dependent DC functions and regulates experimental graft-versus-host disease in mice.
The Journal of clinical investigation 2008;118(7):2562-73.
2008: Nold Marcel F; Nold-Petry Claudia A; Pott Gregory B; Zepp Jarod A; Saavedra Milene T; Kim Soo-Hyun; Dinarello Charles A
Endogenous IL-32 controls cytokine and HIV-1 production.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(1):557-65.
2008: Sennello Joseph A; Fayad Raja; Pini Maria; Gove Melissa E; Ponemone Venkatesh; Cabay Robert J; Siegmund Britta; Dinarello Charles A; Fantuzzi Giamila
Interleukin-18, together with interleukin-12, induces severe acute pancreatitis in obese but not in nonobese leptin-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(23):8085-90.
2008: Saavedra Milene T; Patterson Abby D; West James; Randell Scott H; Riches David W; Malcolm Ken C; Cool Carlyne D; Nick Jerry A; Dinarello Charles A
Abrogation of anti-inflammatory transcription factor LKLF in neutrophil-dominated airways.
American journal of respiratory cell and molecular biology 2008;38(6):679-88.
2008: Cha John; Wang Zhiping; Ao Lihua; Zou Ning; Dinarello Charles A; Banerjee Anirban; Fullerton David A; Meng Xianzhong
Cytokines link Toll-like receptor 4 signaling to cardiac dysfunction after global myocardial ischemia.
The Annals of thoracic surgery 2008;85(5):1678-85.
2008: Glauben R; Batra A; Stroh T; Erben U; Fedke I; Lehr H A; Leoni F; Mascagni P; Dinarello C A; Zeitz M; Siegmund B
Histone deacetylases: novel targets for prevention of colitis-associated cancer in mice.
Gut 2008;57(5):613-22.
2008: Sharma Sheetal; Kulk Nicole; Nold Marcel F; Gräf Ralph; Kim Soo-Hyun; Reinhardt Dietrich; Dinarello Charles A; Bufler Philip
The IL-1 family member 7b translocates to the nucleus and down-regulates proinflammatory cytokines.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(8):5477-82.
2008: Kim Ki-Hong; Shim Jung-Hyun; Seo Eun-Hee; Cho Min-Chul; Kang Jung-Woo; Kim Soo-Hyun; Yu Dae-Yeul; Song Eun-Young; Lee Hee-Gu; Sohn Jung-Hoon; Kim JinMan; Dinarello Charles A; Yoon Do-Young
Interleukin-32 monoclonal antibodies for immunohistochemistry, Western blotting, and ELISA.
Journal of immunological methods 2008;333(1-2):38-50.
2008: Netea Mihai G; Lewis Eli C; Azam Tania; Joosten Leo A B; Jaekal Jun; Bae Su-Young; Dinarello Charles A; Kim Soo-Hyun
Interleukin-32 induces the differentiation of monocytes into macrophage-like cells.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(9):3515-20.
2008: Manzer Rizwan; Dinarello Charles A; McConville Glen; Mason Robert J
Ozone exposure of macrophages induces an alveolar epithelial chemokine response through IL-1alpha.
American journal of respiratory cell and molecular biology 2008;38(3):318-23.
2008: Marcondes A Mario; Mhyre Andrew J; Stirewalt Derek L; Kim Soo-Hyun; Dinarello Charles A; Deeg H Joachim
Dysregulation of IL-32 in myelodysplastic syndrome and chronic myelomonocytic leukemia modulates apoptosis and impairs NK function.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(8):2865-70.
2008: Meng Xianzhong; Ao Lihua; Song Yong; Babu Ashok; Yang Xiaoping; Wang Maorong; Weyant Michael J; Dinarello Charles A; Cleveland Joseph C; Fullerton David A
Expression of functional Toll-like receptors 2 and 4 in human aortic valve interstitial cells: potential roles in aortic valve inflammation and stenosis.
American journal of physiology. Cell physiology 2008;294(1):C29-35.
2007: Jaekal Jun; Abraham Edward; Azam Tania; Netea Mihai G; Dinarello Charles A; Lim Jong-Seok; Yang Young; Yoon Do-Young; Kim Soo-Hyun
Individual LPS responsiveness depends on the variation of toll-like receptor (TLR) expression level.
Journal of microbiology and biotechnology 2007;17(11):1862-7.
2007: Dinarello Charles A
Historical insights into cytokines.
European journal of immunology 2007;37 Suppl 1():S34-45.
2007: Lavi Galia; Voronov Elena; Dinarello Charles A; Apte Ron N; Cohen Smadar
Sustained delivery of IL-1 Ra from biodegradable microspheres reduces the number of murine B16 melanoma lung metastases.
Journal of controlled release : official journal of the Controlled Release Society 2007;123(2):123-30.
2007: Kamari Yehuda; Werman-Venkert Rachel; Shaish Aviv; Werman Ariel; Harari Ayelet; Gonen Ayelet; Voronov Elena; Grosskopf Itamar; Sharabi Yehonatan; Grossman Ehud; Iwakura Yoichiro; Dinarello Charles A; Apte Ron N; Harats Dror
Differential role and tissue specificity of interleukin-1alpha gene expression in atherogenesis and lipid metabolism.
Atherosclerosis 2007;195(1):31-8.
2007: Dinarello Charles A
Mutations in cryopyrin: bypassing roadblocks in the caspase 1 inflammasome for interleukin-1beta secretion and disease activity.
Arthritis and rheumatism 2007;56(9):2817-22.
2007: Yoon Do-Young; Dinarello Charles A
Differential effects of anti-IL-1R accessory protein antibodies on IL-1alpha or IL-1beta-induced production of PGE(2) and IL-6 from 3T3-L1 cells.
Journal of biochemistry and molecular biology 2007;40(4):562-70.
2007: Faubel Sarah; Lewis Eli C; Reznikov Leonid; Ljubanovic Danica; Hoke Thomas S; Somerset Hilary; Oh Dong-Jin; Lu Lawrence; Klein Christina L; Dinarello Charles A; Edelstein Charles L
Cisplatin-induced acute renal failure is associated with an increase in the cytokines interleukin (IL)-1beta, IL-18, IL-6, and neutrophil infiltration in the kidney.
The Journal of pharmacology and experimental therapeutics 2007;322(1):8-15.
2007: Ao Lihua; Song Yong; Fullerton David A; Dinarello Charles A; Meng Xianzhong
The interaction between myocardial depressant factors in endotoxemic cardiac dysfunction: role of TNF-alpha in TLR4-mediated ICAM-1 expression.
Cytokine 2007;38(3):124-9.
2007: Pott Gregory B; Sailer Carrie A; Porat Reuven; Peskind Robert L; Fuchs Amy C; Angel Jonathan B; Skolnik Paul R; Jacobson Mark A; Giordano Michael F; Lebeaut Alexandre; Grint Paul C; Dinarello Charles A; Shapiro Leland
Effect of a four-week course of interleukin-10 on cytokine production in a placebo-controlled study of HIV-1-infected subjects.
European cytokine network 2007;18(2):49-58.
2007: Auron Philip E; Webb Andrew C; Rosenwasser Lanny J; Mucci Steven F; Rich Alexander; Wolff Sheldon M; Dinarello Charles A
Nucleotide sequence of human monocyte interleukin 1 precursor cDNA. Proc. Natl. Acad. Sci. USA 1984. 81: 7907-7911.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(9):5413-7.
2007: Dinarello Charles A
A signal for the caspase-1 inflammasome free of TLR.
Immunity 2007;26(4):383-5.
2007: Edelstein Charles L; Hoke Thomas S; Somerset Hilary; Fang Wenfeng; Klein Christina L; Dinarello Charles A; Faubel Sarah
Proximal tubules from caspase-1-deficient mice are protected against hypoxia-induced membrane injury.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2007;22(4):1052-61.
2007: Hurgin Vladimir; Novick Daniela; Werman Ariel; Dinarello Charles A; Rubinstein Menachem
Antiviral and immunoregulatory activities of IFN-gamma depend on constitutively expressed IL-1alpha.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(12):5044-9.
2007: Sailer Carrie A; Pott Gregory B; Dinarello Charles A; Whinney Samantha Ma; Forster Jeri E; Larson-Duran Jacqueline K; Landay Alan; Al-Harthi Lena; Schooley Robert T; Benson Constance A; Judson Franklyn N; Thompson Melanie; Palella Frank J; Shapiro Leland
Whole-blood interleukin-18 level during early HIV-1 infection is associated with reduced CXCR4 coreceptor expression and interferon- gamma levels.
The Journal of infectious diseases 2007;195(5):734-8.
2007: Krelin Yakov; Voronov Elena; Dotan Shahar; Elkabets Moshe; Reich Eli; Fogel Mina; Huszar Monika; Iwakura Yoichiro; Segal Shraga; Dinarello Charles A; Apte Ron N
Interleukin-1beta-driven inflammation promotes the development and invasiveness of chemical carcinogen-induced tumors.
Cancer research 2007;67(3):1062-71.
2007: Dinarello Charles A
Interleukin-18 and the pathogenesis of inflammatory diseases.
Seminars in nephrology 2007;27(1):98-114.
2006: Boraschi Diana; Dinarello Charles A
IL-18 in autoimmunity: review.
European cytokine network 2006;17(4):224-52.
2006: Netea Mihai G; Azam Tania; Ferwerda Gerben; Girardin Stephen E; Kim Soo-Hyun; Dinarello Charles A
Triggering receptor expressed on myeloid cells-1 (TREM-1) amplifies the signals induced by the NACHT-LRR (NLR) pattern recognition receptors.
Journal of leukocyte biology 2006;80(6):1454-61.
2006: Lewis Eli C; Dinarello Charles A
Responses of IL-18- and IL-18 receptor-deficient pancreatic islets with convergence of positive and negative signals for the IL-18 receptor.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(45):16852-7.
2006: Dinarello C A; Kim S-H
IL-32, a novel cytokine with a possible role in disease.
Annals of the rheumatic diseases 2006;65 Suppl 3():iii61-4.
2006: Dinarello Charles A
The paradox of pro-inflammatory cytokines in cancer.
Cancer metastasis reviews 2006;25(3):307-13.
2006: Vidal-Vanaclocha Fernando; Mendoza Lorea; Telleria Naiara; Salado Clarisa; Valcárcel María; Gallot Natalia; Carrascal Teresa; Egilegor Eider; Beaskoetxea Jabier; Dinarello Charles A
Clinical and experimental approaches to the pathophysiology of interleukin-18 in cancer progression.
Cancer metastasis reviews 2006;25(3):417-34.
2006: Edwards Carl K; Bendele Alison M; Reznikov Leonid I; Fantuzzi Giamila; Chlipala Elizabeth S; Li Li; Moldawer Lyle L; Mountz John D; Li Yi-Yang Yvonne; Dinarello Charles A
Soluble human p55 and p75 tumor necrosis factor receptors reverse spontaneous arthritis in transgenic mice expressing transmembrane tumor necrosis factor alpha.
Arthritis and rheumatism 2006;54(9):2872-85.
2006: Carta Sonia; Tassi Sara; Semino Claudia; Fossati Gianluca; Mascagni Paolo; Dinarello Charles A; Rubartelli Anna
Histone deacetylase inhibitors prevent exocytosis of interleukin-1beta-containing secretory lysosomes: role of microtubules.
Blood 2006;108(5):1618-26.
2006: Netea Mihai G; Azam Tania; Lewis Eli C; Joosten Leo A B; Wang Maorong; Langenberg Dennis; Meng Xianzhong; Chan Edward D; Yoon Do-Young; Ottenhoff Tom; Kim Soo-Hyun; Dinarello Charles A
Mycobacterium tuberculosis induces interleukin-32 production through a caspase- 1/IL-18/interferon-gamma-dependent mechanism.
PLoS medicine 2006;3(8):e277.
2006: Dvorkin Tatyana; Song Xiaoping; Argov Shmuel; White Rosalyn M; Zoller Margot; Segal Shraga; Dinarello Charles A; Voronov Elena; Apte Ron N
Immune phenomena involved in the in vivo regression of fibrosarcoma cells expressing cell-associated IL-1alpha.
Journal of leukocyte biology 2006;80(1):96-106.
2006: Abraham Edward; Nick Jerry A; Azam Tania; Kim Soo Hyun; Mira Jean-Paul; Svetkauskaite Daiva; He Qianbin; Zamora Marty; Murphy James; Park Jong Sung; Overdier Katherine; Dinarello Charles A
Peripheral blood neutrophil activation patterns are associated with pulmonary inflammatory responses to lipopolysaccharide in humans.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(12):7753-60.
2006: Netea Mihai G; Joosten Leo A B; Lewis Eli; Jensen Dalan R; Voshol Peter J; Kullberg Bart Jan; Tack Cees J; van Krieken Han; Kim Soo-Hyun; Stalenhoef Anton F; van de Loo Fons A; Verschueren Ineke; Pulawa Leslie; Akira Shizuo; Eckel Robert H; Dinarello Charles A; van den Berg Wim; van der Meer Jos W M
Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance.
Nature medicine 2006;12(6):650-6.
2006: Glauben Rainer; Batra Arvind; Fedke Inka; Zeitz Martin; Lehr Hans A; Leoni Flavio; Mascagni Paolo; Fantuzzi Giamila; Dinarello Charles A; Siegmund Britta
Histone hyperacetylation is associated with amelioration of experimental colitis in mice.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(8):5015-22.
2006: Morris Alison M; Sennello Joseph A; Fayad Raja A; Eckel Robert H; Dinarello Charles A; Fantuzzi Giamila
T cell-mediated hepatic inflammation modulates adiponectin levels in mice: role of tumor necrosis factor alpha.
Metabolism: clinical and experimental 2006;55(4):555-9.
2006: Joosten Leo A B; Netea Mihai G; Kim Soo-Hyun; Yoon Do-Young; Oppers-Walgreen Birgitte; Radstake Timothy R D; Barrera Pilar; van de Loo Fons A J; Dinarello Charles A; van den Berg Wim B
IL-32, a proinflammatory cytokine in rheumatoid arthritis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(9):3298-303.
2006: Novick Daniela; Rubinstein Menachem; Azam Tania; Rabinkov Aharon; Dinarello Charles A; Kim Soo-Hyun
Proteinase 3 is an IL-32 binding protein.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(9):3316-21.
2006: Dinarello Charles A
Interleukin 1 and interleukin 18 as mediators of inflammation and the aging process.
The American journal of clinical nutrition 2006;83(2):447S-455S.
2006: Portnoy Joshua; Pan Tianli; Dinarello Charles A; Shannon John M; Westcott Jay Y; Zhang Lening; Mason Robert J
Alveolar type II cells inhibit fibroblast proliferation: role of IL-1alpha.
American journal of physiology. Lung cellular and molecular physiology 2006;290(2):L307-16.
2006: Rodriguez Robert M; Abdullah Rabiatu; Miller Robert; Barry Linda; Lungstras-Bufler Kathrin; Bufler Phillip; Dinarello Charles A; Abraham Ed
A pilot study of cytokine levels and white blood cell counts in the diagnosis of necrotizing fasciitis.
The American journal of emergency medicine 2006;24(1):58-61.
2006: Dinarello C A
Inhibitors of histone deacetylases as anti-inflammatory drugs.
Ernst Schering Research Foundation workshop 2006;(56):45-60.
2005: Dinarello Charles A
Interleukin-1beta.
Critical care medicine 2005;33(12 Suppl):S460-2.
2005: Song Xiaoping; Krelin Yakov; Dvorkin Tatyana; Bjorkdahl Olle; Segal Shraga; Dinarello Charles A; Voronov Elena; Apte Ron N
CD11b+/Gr-1+ immature myeloid cells mediate suppression of T cells in mice bearing tumors of IL-1beta-secreting cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(12):8200-8.
2005: Dinarello Charles A
An IL-1 family member requires caspase-1 processing and signals through the ST2 receptor.
Immunity 2005;23(5):461-2.
2005: Netea Mihai G; Azam Tania; Ferwerda Gerben; Girardin Stephen E; Walsh Mark; Park Jong-Sung; Abraham Edward; Kim Jin-Man; Yoon Do-Young; Dinarello Charles A; Kim Soo-Hyun
IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(45):16309-14.
2005: Lee Kyung-Ae; Cho Kyung-Joo; Kim Soo-Hyun; Shim Jung-Hyun; Lim Jong-Seok; Cho Dae-Ho; Song Min-Sung; Dinarello Charles A; Yoon Do-Young
IL-18 E42A mutant is resistant to the inhibitory effects of HPV-16 E6 and E7 oncogenes on the IL-18-mediated immune response.
Cancer letters 2005;229(2):261-70.
2005: Mazodier Karin; Marin Valérie; Novick Daniela; Farnarier Catherine; Robitail Stéphane; Schleinitz Nicolas; Veit Véronique; Paul Pascale; Rubinstein Menachem; Dinarello Charles A; Harlé Jean-Robert; Kaplanski Gilles
Severe imbalance of IL-18/IL-18BP in patients with secondary hemophagocytic syndrome.
Blood 2005;106(10):3483-9.
2005: Clarke Jason H; Cha John Y; Walsh Mark D; Gamboni-Robertson Fabia; Banerjee Anirban; Reznikov Leonid L; Dinarello Charles A; Harken Alden H; McCarter Martin D
Melanoma inhibits macrophage activation by suppressing toll-like receptor 4 signaling.
Journal of the American College of Surgeons 2005;201(3):418-25.
2005: Lewis Eli C; Shapiro Leland; Bowers Owen J; Dinarello Charles A
Alpha1-antitrypsin monotherapy prolongs islet allograft survival in mice.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(34):12153-8.
2005: Fayad Raja; Sennello Joseph A; Kim Soo-Hyun; Pini Maria; Dinarello Charles A; Fantuzzi Giamila
Induction of thymocyte apoptosis by systemic administration of concanavalin A in mice: role of TNF-alpha, IFN-gamma and glucocorticoids.
European journal of immunology 2005;35(8):2304-12.
2005: Dinarello Charles A
The many worlds of reducing interleukin-1.
Arthritis and rheumatism 2005;52(7):1960-7.
2005: Numerof Robert P; Dinarello Charles A; Asadullah Khusru
Cytokines as potential therapeutic targets for inflammatory skin diseases.
European cytokine network 2005;16(2):101-3.
2005: Fitzgerald Avril A; Leclercq Sharon A; Yan Alexander; Homik Joanne E; Dinarello Charles A
Rapid responses to anakinra in patients with refractory adult-onset Still's disease.
Arthritis and rheumatism 2005;52(6):1794-803.
2005: Dinarello Charles A
Blocking IL-1 in systemic inflammation.
The Journal of experimental medicine 2005;201(9):1355-9.
2005: Sennello Joseph A; Fayad Raja; Morris Alison M; Eckel Robert H; Asilmaz Esra; Montez Jason; Friedman Jeffrey M; Dinarello Charles A; Fantuzzi Giamila
Regulation of T cell-mediated hepatic inflammation by adiponectin and leptin.
Endocrinology 2005;146(5):2157-64.
2005: Wang Wei; Faubel Sarah; Ljubanovic Danica; Mitra Amit; Falk Sandor A; Kim Jun; Tao Yunxia; Soloviev Andrei; Reznikov Leonid L; Dinarello Charles A; Schrier Robert W; Edelstein Charles L
Endotoxemic acute renal failure is attenuated in caspase-1-deficient mice.
American journal of physiology. Renal physiology 2005;288(5):F997-1004.
2005: Dinarello Charles A
Differences between anti-tumor necrosis factor-alpha monoclonal antibodies and soluble TNF receptors in host defense impairment.
The Journal of rheumatology. Supplement 2005;74():40-7.
2005: Kumar Anand; Zanotti Sergio; Bunnell Gene; Habet Kalim; Añel Ramon; Neumann Alex; Cheang Mary; Dinarello Charles A; Cutler David; Parrillo Joseph E
Interleukin-10 blunts the human inflammatory response to lipopolysaccharide without affecting the cardiovascular response.
Critical care medicine 2005;33(2):331-40.
2005: Leoni Flavio; Fossati Gianluca; Lewis Eli C; Lee Jae-Kwon; Porro Giulia; Pagani Paolo; Modena Daniela; Moras Maria Lusia; Pozzi Pietro; Reznikov Leonid L; Siegmund Britta; Fantuzzi Giamila; Dinarello Charles A; Mascagni Paolo
The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo.
Molecular medicine (Cambridge, Mass.) 2005;11(1-12):1-15.
2005: Ludwiczek Othmar; Kaser Arthur; Novick Daniela; Dinarello Charles A; Rubinstein Menachem; Tilg Herbert
Elevated systemic levels of free interleukin-18 (IL-18) in patients with Crohn's disease.
European cytokine network 2005;16(1):27-33.
2005: Kim Soo-Hyun; Han Sun-Young; Azam Tania; Yoon Do-Young; Dinarello Charles A
Interleukin-32: a cytokine and inducer of TNFalpha.
Immunity 2005;22(1):131-42.
2005: Stuyt Rogier J L; Netea Mihai G; Verschueren Ineke; Dinarello Charles A; Kullberg Bart Jan; van der Meer Jos W M
Interleukin-18 does not modulate the acute-phase response.
Journal of endotoxin research 2005;11(2):85-8.
2004: Lee Hee-Gu; Kim Hyoson; Oh Won-Keun; Yu Kyung-Ae; Choe Yong-Kyung; Ahn Jong-Seog; Kim Dong-Soo; Kim Soo-Hyun; Dinarello Charles A; Kim Kilhyoun; Yoon Do-Young
Tetramethoxy hydroxyflavone p7F downregulates inflammatory mediators via the inhibition of nuclear factor kappaB.
Annals of the New York Academy of Sciences 2004;1030():555-68.
2004: Faubel Sarah; Ljubanovic Danica; Reznikov Leonid; Somerset Hilary; Dinarello Charles A; Edelstein Charles L
Caspase-1-deficient mice are protected against cisplatin-induced apoptosis and acute tubular necrosis.
Kidney international 2004;66(6):2202-13.
2004: Ludwiczek O; Vannier E; Borggraefe I; Kaser A; Siegmund B; Dinarello C A; Tilg H
Imbalance between interleukin-1 agonists and antagonists: relationship to severity of inflammatory bowel disease.
Clinical and experimental immunology 2004;138(2):323-9.
2004: Siegmund Britta; Sennello Joseph A; Lehr Hans A; Senaldi Giorgio; Dinarello Charles A; Fantuzzi Giamila
Frontline: interferon regulatory factor-1 as a protective gene in intestinal inflammation: role of TCR gamma delta T cells and interleukin-18-binding protein.
European journal of immunology 2004;34(9):2356-64.
2004: Dinarello Charles A
Therapeutic strategies to reduce IL-1 activity in treating local and systemic inflammation.
Current opinion in pharmacology 2004;4(4):378-85.
2004: Netea Mihai G; Kullberg Bart Jan; Jacobs Liesbeth E H; Verver-Jansen Trees J G; van der Ven-Jongekrijg Johanna; Galama Jochem M D; Stalenhoef Anton F H; Dinarello Charles A; Van der Meer Jos W M
Chlamydia pneumoniae stimulates IFN-gamma synthesis through MyD88-dependent, TLR2- and TLR4-independent induction of IL-18 release.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(2):1477-82.
2004: Bufler Philip; Gamboni-Robertson Fabia; Azam Tania; Kim Soo-Hyun; Dinarello Charles A
Interleukin-1 homologues IL-1F7b and IL-18 contain functional mRNA instability elements within the coding region responsive to lipopolysaccharide.
The Biochemical journal 2004;381(Pt 2):503-10.
2004: Lee Jae-Kwon; Kim Soo-Hyun; Lewis Eli C; Azam Tania; Reznikov Leonid L; Dinarello Charles A
Differences in signaling pathways by IL-1beta and IL-18.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(23):8815-20.
2004: Park Jung-Won; Taube Christian; Swasey Christina; Kodama Taku; Joetham Anthony; Balhorn Annette; Takeda Katsuyuki; Miyahara Nobuaki; Allen Corrie B; Dakhama Azzeddine; Kim Soo-Hyun; Dinarello Charles A; Gelfand Erwin W
Interleukin-1 receptor antagonist attenuates airway hyperresponsiveness following exposure to ozone.
American journal of respiratory cell and molecular biology 2004;30(6):830-6.
2004: Taube Christian; Nick Jerry A; Siegmund Britta; Duez Catherine; Takeda Katsuyuki; Rha Yeong-Ho; Park Jung-Won; Joetham Anthony; Poch Katie; Dakhama Azzeddine; Dinarello Charles A; Gelfand Erwin W
Inhibition of early airway neutrophilia does not affect development of airway hyperresponsiveness.
American journal of respiratory cell and molecular biology 2004;30(6):837-43.
2004: Reznikov L L; Waksman J; Azam T; Kim S H; Bufler P; Niwa T; Werman A; Zhang X; Pischetsrieder M; Shaldon S; Dinarello C A
Effect of advanced glycation end products on endotoxin-induced TNF-alpha, IL-1beta and IL-8 in human peripheral blood mononuclear cells.
Clinical nephrology 2004;61(5):324-36.
2004: Dinarello Charles A
Interleukin-18 and the treatment of rheumatoid arthritis.
Rheumatic diseases clinics of North America 2004;30(2):417-34, ix.
2004: Lungstras-Bufler Kathrin; Bufler Philip; Abdullah Rabiatu; Rutherford Christine; Endres Stefan; Abraham Edward; Dinarello Charles A; Rodriguez Robert M
High cytokine levels at admission are associated with fatal outcome in patients with necrotizing fasciitis.
European cytokine network 2004;15(2):135-8.
2004: Schottelius Arndt J G; Moldawer Lyle L; Dinarello Charles A; Asadullah Khusru; Sterry Wolfram; Edwards Carl K
Biology of tumor necrosis factor-alpha- implications for psoriasis.
Experimental dermatology 2004;13(4):193-222.
2004: Dinarello Charles A
Unraveling the NALP-3/IL-1beta inflammasome: a big lesson from a small mutation.
Immunity 2004;20(3):243-4.
2004: Reddy Pavan; Maeda Yoshinobu; Hotary Kevin; Liu Chen; Reznikov Leonid L; Dinarello Charles A; Ferrara James L M
Histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces acute graft-versus-host disease and preserves graft-versus-leukemia effect.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(11):3921-6.
2004: Werman Ariel; Werman-Venkert Rachel; White Rosalyn; Lee Jae-Kwon; Werman Batsheva; Krelin Yakov; Voronov Elena; Dinarello Charles A; Apte Ron N
The precursor form of IL-1alpha is an intracrine proinflammatory activator of transcription.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(8):2434-9.
2004: Wang Meijing; Sankula Rajakumar; Tsai Ben M; Meldrum Kirstan K; Turrentine Mark; March Keith L; Brown John W; Dinarello Charles A; Meldrum Daniel R
P38 MAPK mediates myocardial proinflammatory cytokine production and endotoxin-induced contractile suppression.
Shock (Augusta, Ga.) 2004;21(2):170-4.
2004: Bar Dganit; Apte Ron N; Voronov Elena; Dinarello Charles A; Cohen Smadar
A continuous delivery system of IL-1 receptor antagonist reduces angiogenesis and inhibits tumor development.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(1):161-3.
2004: Dinarello Charles A
Infection, fever, and exogenous and endogenous pyrogens: some concepts have changed.
Journal of endotoxin research 2004;10(4):201-22.
2003: Azam Tania; Novick Daniela; Bufler Philip; Yoon Do-Young; Rubinstein Menachem; Dinarello Charles A; Kim Soo Hyun
Identification of a critical Ig-like domain in IL-18 receptor alpha and characterization of a functional IL-18 receptor complex.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(12):6574-80.
2003: Song Xiaoping; Voronov Elena; Dvorkin Tatyana; Fima Eyal; Cagnano Emanuela; Benharroch Daniel; Shendler Yaakov; Bjorkdahl Olle; Segal Shraga; Dinarello Charles A; Apte Ron N
Differential effects of IL-1 alpha and IL-1 beta on tumorigenicity patterns and invasiveness.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(12):6448-56.
2003: Nolsøe Rúna L; Pociot Flemming; Novick Daniela; Rubinstein Menachem; Kim Soo-Hyun; Dinarello Charles A; Mandrup-Poulsen Thomas
Mutation scan of a type 1 diabetes candidate gene: the human interleukin-18 binding protein gene.
Annals of the New York Academy of Sciences 2003;1005():332-9.
2003: Lonnemann G; Novick D; Rubinstein M; Dinarello C A
Interleukin-18, interleukin-18 binding protein and impaired production of interferon-gamma in chronic renal failure.
Clinical nephrology 2003;60(5):327-34.
2003: Stuyt Rogier J L; Netea Mihai G; Geijtenbeek Teunis B H; Kullberg Bart Jan; Dinarello Charles A; van der Meer Jos W M
Selective regulation of intercellular adhesion molecule-1 expression by interleukin-18 and interleukin-12 on human monocytes.
Immunology 2003;110(3):329-34.
2003: Bossù Paola; Neumann Detlef; Del Giudice Elda; Ciaramella Antonio; Gloaguen Isabelle; Fantuzzi Giamila; Dinarello Charles A; Di Carlo Emma; Musiani Piero; Meroni Pier Luigi; Caselli Gianfranco; Ruggiero Paolo; Boraschi Diana
IL-18 cDNA vaccination protects mice from spontaneous lupus-like autoimmune disease.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(24):14181-6.
2003: Fantuzzi Giamila; Banda Nirmal K; Guthridge Carla; Vondracek Andrea; Kim Soo-Hyun; Siegmund Britta; Azam Tania; Sennello Joseph A; Dinarello Charles A; Arend William P
Generation and characterization of mice transgenic for human IL-18-binding protein isoform a.
Journal of leukocyte biology 2003;74(5):889-96.
2003: Rijneveld Anita W; Florquin Sandrine; Speelman Peter; Edwards Carl K; Dinarello Charles A; van der Poll Tom
Interleukin-1 receptor antagonist transiently impairs antibacterial defense but not survival in murine pneumococcal pneumonia.
European cytokine network 2003;14(4):242-5.
2003: Roubenoff Ronenn; Parise Helen; Payette Hélène A; Abad Leslie W; D'Agostino Ralph; Jacques Paul F; Wilson Peter W F; Dinarello Charles A; Harris Tamara B
Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study.
The American journal of medicine 2003;115(6):429-35.
2003: Feezor Robert J; Oberholzer Caroline; Baker Henry V; Novick Daniela; Rubinstein Menachem; Moldawer Lyle L; Pribble John; Souza Sonia; Dinarello Charles A; Ertel Wolfgang; Oberholzer Andreas
Molecular characterization of the acute inflammatory response to infections with gram-negative versus gram-positive bacteria.
Infection and immunity 2003;71(10):5803-13.
2003: Selzman Craig H; Netea Mihai G; Zimmerman Michael A; Weinberg Adriana; Reznikov Leonid L; Grover Frederick L; Dinarello Charles A
Atherogenic effects of Chlamydia pneumoniae: refuting the innocent bystander hypothesis.
The Journal of thoracic and cardiovascular surgery 2003;126(3):688-93.
2003: Payette Hélène; Roubenoff Ronenn; Jacques Paul F; Dinarello Charles A; Wilson Peter W F; Abad Leslie W; Harris Tamara
Insulin-like growth factor-1 and interleukin 6 predict sarcopenia in very old community-living men and women: the Framingham Heart Study.
Journal of the American Geriatrics Society 2003;51(9):1237-43.
2003: Gangemi Sebastiano; Basile Giorgio; Merendino Rosaria Alba; Minciullo Paola Lucia; Novick Daniela; Rubinstein Menachem; Dinarello Charles A; Lo Balbo Claudia; Franceschi Claudio; Basili Stefania; D' Urbano Etrusca; Daví Giovanni; Nicita-Mauro Vittorio; Romano Mario
Increased circulating Interleukin-18 levels in centenarians with no signs of vascular disease: another paradox of longevity?
Experimental gerontology 2003;38(6):669-72.
2003: Dinarello Charles A; Fantuzzi Giamila
Interleukin-18 and host defense against infection.
The Journal of infectious diseases 2003;187 Suppl 2():S370-84.
2003: Dinarello Charles A
Anti-cytokine therapeutics and infections.
Vaccine 2003;21 Suppl 2():S24-34.
2003: Vasan Ramachandran S; Sullivan Lisa M; Roubenoff Ronenn; Dinarello Charles A; Harris Tamara; Benjamin Emelia J; Sawyer Douglas B; Levy Daniel; Wilson Peter W F; D'Agostino Ralph B;
Inflammatory markers and risk of heart failure in elderly subjects without prior myocardial infarction: the Framingham Heart Study.
Circulation 2003;107(11):1486-91.
2003: Voronov Elena; Shouval Dror S; Krelin Yakov; Cagnano Emanuela; Benharroch Daniel; Iwakura Yoichiro; Dinarello Charles A; Apte Ron N
IL-1 is required for tumor invasiveness and angiogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2645-50.
2003: Que Xuchu; Kim Soo-Hyun; Sajid Mohammed; Eckmann Lars; Dinarello Charles A; McKerrow James H; Reed Sharon L
A surface amebic cysteine proteinase inactivates interleukin-18.
Infection and immunity 2003;71(3):1274-80.
2003: Banda Nirmal K; Vondracek Andrea; Kraus Damian; Dinarello Charles A; Kim Soo-Hyun; Bendele Alison; Senaldi Giorgio; Arend William P
Mechanisms of inhibition of collagen-induced arthritis by murine IL-18 binding protein.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(4):2100-5.
2003: Stuyt Rogier J L; Kim Soo-Hyun; Reznikov Leonid L; Fantuzzi Giamila; Novick Daniela; Rubinstein Menachem; Kullberg Bart Jan; van der Meer Jos W M; Dinarello Charles A; Netea Mihai G
Regulation of Staphylococcus epidermidis-induced IFN-gamma in whole human blood: the role of endogenous IL-18, IL-12, IL-1, and TNF.
Cytokine 2003;21(2):65-73.
2003: Carrascal Maria Teresa; Mendoza Lorea; Valcárcel Maria; Salado Clarisa; Egilegor Eider; Tellería Naiara; Vidal-Vanaclocha Fernando; Dinarello Charles A
Interleukin-18 binding protein reduces b16 melanoma hepatic metastasis by neutralizing adhesiveness and growth factors of sinusoidal endothelium.
Cancer research 2003;63(2):491-7.
2003: Dinarello Charles A
Setting the cytokine trap for autoimmunity.
Nature medicine 2003;9(1):20-2.
2003: Dinarello Charles A; Novick Daniela; Rubinstein Menachem; Lonnemann Gerhard
Interleukin 18 and interleukin 18 binding protein: possible role in immunosuppression of chronic renal failure.
Blood purification 2003;21(3):258-70.
2003: Lonnemann Gerhard; Novick Daniela; Rubinstein Menachem; Passlick-Deetjen Jutta; Lang Dietmar; Dinarello Charles A
A switch to high-flux helixone membranes reverses suppressed interferon-gamma production in patients on low-flux dialysis.
Blood purification 2003;21(3):225-31.
2002: Ludwiczek Othmar; Kaser Arthur; Novick Daniela; Dinarello Charles A; Rubinstein Menachem; Vogel Wolfgang; Tilg Herbert
Plasma levels of interleukin-18 and interleukin-18 binding protein are elevated in patients with chronic liver disease.
Journal of clinical immunology 2002;22(6):331-7.
2002: Dinarello Charles A; Abraham Edward
Does blocking cytokines in sepsis work?
American journal of respiratory and critical care medicine 2002;166(9):1156-7.
2002: Bufler Philip; Azam Tania; Gamboni-Robertson Fabia; Reznikov Leonid L; Kumar Sanjay; Dinarello Charles A; Kim Soo-Hyun
A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(21):13723-8.
2002: Dinarello C A
The IL-1 family and inflammatory diseases.
Clinical and experimental rheumatology 2002;20(5 Suppl 27):S1-13.
2002: Yatsiv Ido; Morganti-Kossmann Maria C; Perez Daniel; Dinarello Charles A; Novick Daniela; Rubinstein Menachem; Otto Viviane I; Rancan Mario; Kossmann Thomas; Redaelli Claudio A; Trentz Otmar; Shohami Esther; Stahel Philip F
Elevated intracranial IL-18 in humans and mice after traumatic brain injury and evidence of neuroprotective effects of IL-18-binding protein after experimental closed head injury.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2002;22(8):971-8.
2002: Wyman Travis H; Dinarello Charles A; Banerjee Anirban; Gamboni-Robertson Fabia; Hiester Andrew A; England Kelly M; Kelher Marguerite; Silliman Christopher C
Physiological levels of interleukin-18 stimulate multiple neutrophil functions through p38 MAP kinase activation.
Journal of leukocyte biology 2002;72(2):401-9.
2002: Raeburn Christopher D; Dinarello Charles A; Zimmerman Michael A; Calkins Casey M; Pomerantz Benjamin J; McIntyre Robert C; Harken Alden H; Meng Xianzhong
Neutralization of IL-18 attenuates lipopolysaccharide-induced myocardial dysfunction.
American journal of physiology. Heart and circulatory physiology 2002;283(2):H650-7.
2002: Ariel Amiram; Novick Daniela; Rubinstein Menachem; Dinarello Charles A; Lider Ofer; Hershkoviz Rami
IL-12 and IL-18 induce MAP kinase-dependent adhesion of T cells to extracellular matrix components.
Journal of leukocyte biology 2002;72(1):192-8.
2002: Stuyt Rogier J L; Netea Mihai G; Verschueren Ineke; Fantuzzi Giamila; Dinarello Charles A; Van Der Meer Jos W M; Kullberg Bart Jan
Role of interleukin-18 in host defense against disseminated Candida albicans infection.
Infection and immunity 2002;70(6):3284-6.
2002: Reznikov Leonid L; Kim Soo-Hyun; Zhou Li; Bufler Philip; Goncharov Igor; Tsang Monica; Dinarello Charles A
The combination of soluble IL-18Ralpha and IL-18Rbeta chains inhibits IL-18-induced IFN-gamma.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2002;22(5):593-601.
2002: Netea Mihai G; Kullberg Bart Jan; Galama Jochem M D; Stalenhoef Anton F H; Dinarello Charles A; Van der Meer Jos W M
Non-LPS components of Chlamydia pneumoniae stimulate cytokine production through Toll-like receptor 2-dependent pathways.
European journal of immunology 2002;32(4):1188-95.
2002: Netea Mihai G; Stuyt Rogier J L; Kim Soo-Hyun; Van der Meer Jos W M; Kullberg Bart Jan; Dinarello Charles A
The role of endogenous interleukin (IL)-18, IL-12, IL-1beta, and tumor necrosis factor-alpha in the production of interferon-gamma induced by Candida albicans in human whole-blood cultures.
The Journal of infectious diseases 2002;185(7):963-70.
2002: Corbaz Anne; ten Hove Tessa; Herren Suzanne; Graber Pierre; Schwartsburd Boris; Belzer Ilana; Harrison Jillian; Plitz Thomas; Kosco-Vilbois Marie H; Kim Soo-Hyun; Dinarello Charles A; Novick Daniela; van Deventer Sander; Chvatchko Yolande
IL-18-binding protein expression by endothelial cells and macrophages is up-regulated during active Crohn's disease.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(7):3608-16.
2002: Im Sin-Hyeog; Kim Soo-Hyun; Azam Tania; Venkatesh Natarajan; Dinarello Charles A; Fuchs Sara; Souroujon Miriam C
Rat interleukin-18 binding protein: cloning, expression, and characterization.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2002;22(3):321-8.
2002: Leoni Flavio; Zaliani Andrea; Bertolini Giorgio; Porro Giulia; Pagani Paolo; Pozzi Pietro; Donà Giancarlo; Fossati Gianluca; Sozzani Silvano; Azam Tania; Bufler Philip; Fantuzzi Giamila; Goncharov Igor; Kim Soo-Hyun; Pomerantz Benjamin J; Reznikov Leonid L; Siegmund Britta; Dinarello Charles A; Mascagni Paolo
The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):2995-3000.
2002: Wieland Catharina W; Siegmund Britta; Senaldi Giorgio; Vasil Michael L; Dinarello Charles A; Fantuzzi Giamila
Pulmonary inflammation induced by Pseudomonas aeruginosa lipopolysaccharide, phospholipase C, and exotoxin A: role of interferon regulatory factor 1.
Infection and immunity 2002;70(3):1352-8.
2002: Gatti Silvia; Beck Jennifer; Fantuzzi Giamila; Bartfai Tamas; Dinarello Charles A
Effect of interleukin-18 on mouse core body temperature.
American journal of physiology. Regulatory, integrative and comparative physiology 2002;282(3):R702-9.
2002: Kim Soo-Hyun; Azam Tania; Novick Daniela; Yoon Do-Young; Reznikov Leonid L; Bufler Philip; Rubinstein Menachem; Dinarello Charles A
Identification of amino acid residues critical for biological activity in human interleukin-18.
The Journal of biological chemistry 2002;277(13):10998-1003.
2002: Schultz Marc J; Rijneveld Anita W; Florquin Sandrine; Edwards Carl K; Dinarello Charles A; van der Poll Tom
Role of interleukin-1 in the pulmonary immune response during Pseudomonas aeruginosa pneumonia.
American journal of physiology. Lung cellular and molecular physiology 2002;282(2):L285-90.
2002: Perales Miguel-Angel; Fantuzzi Giamila; Goldberg Stacie M; Turk Mary Jo; Mortazavi Fariborz; Busam Klaus; Houghton Alan N; Dinarello Charles A; Wolchok Jedd D
GM-CSF DNA induces specific patterns of cytokines and chemokines in the skin: implications for DNA vaccines.
Cytokines, cellular & molecular therapy 2002;7(3):125-33.
2002: Calkins Casey M; Bensard Denis D; Shames Brian D; Pulido Edward J; Abraham Edward; Fernandez Nathan; Meng Xianzhong; Dinarello Charles A; McIntyre Robert C
IL-1 regulates in vivo C-X-C chemokine induction and neutrophil sequestration following endotoxemia.
Journal of endotoxin research 2002;8(1):59-67.
2001: Plater-Zyberk C; Joosten L A; Helsen M M; Sattonnet-Roche P; Siegfried C; Alouani S; van De Loo F A; Graber P; Aloni S; Cirillo R; Lubberts E; Dinarello C A; van Den Berg W B; Chvatchko Y
Therapeutic effect of neutralizing endogenous IL-18 activity in the collagen-induced model of arthritis.
The Journal of clinical investigation 2001;108(12):1825-32.
2001: Dinarello C A
Novel targets for interleukin 18 binding protein.
Annals of the rheumatic diseases 2001;60 Suppl 3():iii18-24.
2001: Siegmund B; Lehr H A; Fantuzzi G; Dinarello C A
IL-1 beta -converting enzyme (caspase-1) in intestinal inflammation.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(23):13249-54.
2001: Siegmund B; Fantuzzi G; Rieder F; Gamboni-Robertson F; Lehr H A; Hartmann G; Dinarello C A; Endres S; Eigler A
Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production.
American journal of physiology. Regulatory, integrative and comparative physiology 2001;281(4):R1264-73.
2001: Choi H J; Dinarello C A; Shapiro L
Interleukin-18 inhibits human immunodeficiency virus type 1 production in peripheral blood mononuclear cells.
The Journal of infectious diseases 2001;184(5):560-8.
2001: Marin V; Farnarier C; Grès S; Kaplanski S; Su M S; Dinarello C A; Kaplanski G
The p38 mitogen-activated protein kinase pathway plays a critical role in thrombin-induced endothelial chemokine production and leukocyte recruitment.
Blood 2001;98(3):667-73.
2001: Stuyt R J; Netea M G; Kim S H; Novick D; Rubinstein M; Kullberg B J; Van der Meer J W; Dinarello C A
Differential roles of interleukin-18 (IL-18) and IL12 for induction of gamma interferon by staphylococcal cell wall components and superantigens.
Infection and immunity 2001;69(8):5025-30.
2001: Novick D; Schwartsburd B; Pinkus R; Suissa D; Belzer I; Sthoeger Z; Keane W F; Chvatchko Y; Kim S H; Fantuzzi G; Dinarello C A; Rubinstein M
A novel IL-18BP ELISA shows elevated serum IL-18BP in sepsis and extensive decrease of free IL-18.
Cytokine 2001;14(6):334-42.
2001: Knotek M; Rogachev B; Wang W; Ecder T; Melnikov V; Gengaro P E; Esson M; Edelstein C L; Dinarello C A; Schrier R W
Endotoxemic renal failure in mice: Role of tumor necrosis factor independent of inducible nitric oxide synthase.
Kidney international 2001;59(6):2243-9.
2001: Melnikov V Y; Ecder T; Fantuzzi G; Siegmund B; Lucia M S; Dinarello C A; Schrier R W; Edelstein C L
Impaired IL-18 processing protects caspase-1-deficient mice from ischemic acute renal failure.
The Journal of clinical investigation 2001;107(9):1145-52.
2001: Kim S H; Azam T; Yoon D Y; Reznikov L L; Novick D; Rubinstein M; Dinarello C A
Site-specific mutations in the mature form of human IL-18 with enhanced biological activity and decreased neutralization by IL-18 binding protein.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3304-9.
2001: Pomerantz B J; Reznikov L L; Harken A H; Dinarello C A
Inhibition of caspase 1 reduces human myocardial ischemic dysfunction via inhibition of IL-18 and IL-1beta.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2871-6.
2001: Vázquez-Torres A; Fantuzzi G; Edwards C K; Dinarello C A; Fang F C
Defective localization of the NADPH phagocyte oxidase to Salmonella-containing phagosomes in tumor necrosis factor p55 receptor-deficient macrophages.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2561-5.
2001: Fantuzzi G; Reed D; Qi M; Scully S; Dinarello C A; Senaldi G
Role of interferon regulatory factor-1 in the regulation of IL-18 production and activity.
European journal of immunology 2001;31(2):369-75.
2001: Kim S H; Reznikov L L; Stuyt R J; Selzman C H; Fantuzzi G; Hoshino T; Young H A; Dinarello C A
Functional reconstitution and regulation of IL-18 activity by the IL-18R beta chain.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(1):148-54.
2001: Dinarello C A; Pomerantz B J
Proinflammatory cytokines in heart disease.
Blood purification 2001;19(3):314-21.
2000: Joosten L A; van De Loo F A; Lubberts E; Helsen M M; Netea M G; van Der Meer J W; Dinarello C A; van Den Berg W B
An IFN-gamma-independent proinflammatory role of IL-18 in murine streptococcal cell wall arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(11):6553-8.
2000: Frishman J I; Edwards C K; Sonnenberg M G; Kohno T; Cohen A M; Dinarello C A
Tumor necrosis factor (TNF)-alpha-induced interleukin-8 in human blood cultures discriminates neutralization by the p55 and p75 TNF soluble receptors.
The Journal of infectious diseases 2000;182(6):1722-30.
2000: Dinarello C A
Targeting interleukin 18 with interleukin 18 binding protein.
Annals of the rheumatic diseases 2000;59 Suppl 1():i17-20.
2000: Dinarello C A
Interleukin-18, a proinflammatory cytokine.
European cytokine network 2000;11(3):483-6.
2000: Netea M G; Puren A J; Dinarello C A
A short course of oral aspirin increases IL-18-induced interferon-gamma production in whole blood cultures.
European cytokine network 2000;11(3):379-82.
2000: Dinarello C A
The role of the interleukin-1-receptor antagonist in blocking inflammation mediated by interleukin-1.
The New England journal of medicine 2000;343(10):732-4.
2000: Dinarello C A
Proinflammatory cytokines.
Chest 2000;118(2):503-8.
2000: Hong T P; Andersen N A; Nielsen K; Karlsen A E; Fantuzzi G; Eizirik D L; Dinarello C A; Mandrup-Poulsen T
Interleukin-18 mRNA, but not interleukin-18 receptor mRNA, is constitutively expressed in islet beta-cells and up-regulated by interferon-gamma.
European cytokine network 2000;11(2):193-205.
2000: Netea M G; Fantuzzi G; Kullberg B J; Stuyt R J; Pulido E J; McIntyre R C; Joosten L A; Van der Meer J W; Dinarello C A
Neutralization of IL-18 reduces neutrophil tissue accumulation and protects mice against lethal Escherichia coli and Salmonella typhimurium endotoxemia.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(5):2644-9.
2000: Reznikov L L; Kim S H; Westcott J Y; Frishman J; Fantuzzi G; Novick D; Rubinstein M; Dinarello C A
IL-18 binding protein increases spontaneous and IL-1-induced prostaglandin production via inhibition of IFN-gamma.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(5):2174-9.
2000: Kim S H; Eisenstein M; Reznikov L; Fantuzzi G; Novick D; Rubinstein M; Dinarello C A
Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(3):1190-5.
2000: Abraham E; Matthay M A; Dinarello C A; Vincent J L; Cohen J; Opal S M; Glauser M; Parsons P; Fisher C J; Repine J E
Consensus conference definitions for sepsis, septic shock, acute lung injury, and acute respiratory distress syndrome: time for a reevaluation.
Critical care medicine 2000;28(1):232-5.
2000: Reznikov L L; Shames B D; Barton H A; Selzman C H; Fantuzzi G; Kim S H; Johnson S M; Dinarello C A
Interleukin-1beta deficiency results in reduced NF-kappaB levels in pregnant mice.
American journal of physiology. Regulatory, integrative and comparative physiology 2000;278(1):R263-70.
2000: Vidal-Vanaclocha F; Fantuzzi G; Mendoza L; Fuentes A M; Anasagasti M J; Martín J; Carrascal T; Walsh P; Reznikov L L; Kim S H; Novick D; Rubinstein M; Dinarello C A
IL-18 regulates IL-1beta-dependent hepatic melanoma metastasis via vascular cell adhesion molecule-1.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(2):734-9.
1999: Sheridan B C; Dinarello C A; Meldrum D R; Fullerton D A; Selzman C H; McIntyre R C
Interleukin-11 attenuates pulmonary inflammation and vasomotor dysfunction in endotoxin-induced lung injury.
The American journal of physiology 1999;277(5 Pt 1):L861-7.
1999: Dinarello C A
Interleukin-18.
Methods (San Diego, Calif.) 1999;19(1):121-32.
1999: Fantuzzi G; Reed D A; Dinarello C A
IL-12-induced IFN-gamma is dependent on caspase-1 processing of the IL-18 precursor.
The Journal of clinical investigation 1999;104(6):761-7.
1999: Cain B S; Meldrum D R; Dinarello C A; Meng X; Joo K S; Banerjee A; Harken A H
Tumor necrosis factor-alpha and interleukin-1beta synergistically depress human myocardial function.
Critical care medicine 1999;27(7):1309-18.
1999: Reznikov L L; Fantuzzi G; Selzman C H; Shames B D; Barton H A; Bell H; McGregor J A; Dinarello C A
Utilization of endoscopic inoculation in a mouse model of intrauterine infection-induced preterm birth: role of interleukin 1beta.
Biology of reproduction 1999;60(5):1231-8.
1999: Granowitz E V; Porat R; Dinarello C A
Circulating leptin during experimental endotoxemia in humans.
The Journal of infectious diseases 1999;179(5):1313-4.
1999: Selzman C H; Shames B D; Reznikov L L; Miller S A; Meng X; Barton H A; Werman A; Harken A H; Dinarello C A; Banerjee A
Liposomal delivery of purified inhibitory-kappaBalpha inhibits tumor necrosis factor-alpha-induced human vascular smooth muscle proliferation.
Circulation research 1999;84(8):867-75.
1999: Netea M G; Kullberg B J; Boerman O C; Verschueren I; Dinarello C A; Van der Meer J W
Soluble murine IL-1 receptor type I induces release of constitutive IL-1 alpha.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(8):4876-81.
1999: Vannier E; Kaser A; Atkins M B; Fantuzzi G; Dinarello C A; Mier J W; Tilg H
Elevated circulating levels of soluble interleukin-1 receptor type II during interleukin-2 immunotherapy.
European cytokine network 1999;10(1):37-42.
1999: Dinarello C A
Cytokines as endogenous pyrogens.
The Journal of infectious diseases 1999;179 Suppl 2():S294-304.
1999: Puren A J; Fantuzzi G; Dinarello C A
Gene expression, synthesis, and secretion of interleukin 18 and interleukin 1beta are differentially regulated in human blood mononuclear cells and mouse spleen cells.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):2256-61.
1999: Dinarello C A; Gatti S; Bartfai T
Fever: links with an ancient receptor.
Current biology : CB 1999;9(4):R147-50.
1999: Fantuzzi G; Dinarello C A
Interleukin-18 and interleukin-1 beta: two cytokine substrates for ICE (caspase-1).
Journal of clinical immunology 1999;19(1):1-11.
1999: Novick D; Kim S H; Fantuzzi G; Reznikov L L; Dinarello C A; Rubinstein M
Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response.
Immunity 1999;10(1):127-36.
1999: Dinarello C A
IL-18: A TH1-inducing, proinflammatory cytokine and new member of the IL-1 family.
The Journal of allergy and clinical immunology 1999;103(1 Pt 1):11-24.
1998: Puren A J; Razeghi P; Fantuzzi G; Dinarello C A
Interleukin-18 enhances lipopolysaccharide-induced interferon-gamma production in human whole blood cultures.
The Journal of infectious diseases 1998;178(6):1830-4.
1998: Meldrum D R; Dinarello C A; Shames B D; Cleveland J C; Cain B S; Banerjee A; Meng X; Harken A H
Ischemic preconditioning decreases postischemic myocardial tumor necrosis factor-alpha production. Potential ultimate effector mechanism of preconditioning.
Circulation 1998;98(19 Suppl):II214-8; discussion II218-9.
1998: Reznikov L L; Puren A J; Fantuzzi G; Mühl H; Shapiro L; Yoon D Y; Cutler D L; Dinarello C A
Spontaneous and inducible cytokine responses in healthy humans receiving a single dose of IFN-alpha2b: increased production of interleukin-1 receptor antagonist and suppression of IL-1-induced IL-8.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1998;18(10):897-903.
1998: Shapiro L; Puren A J; Barton H A; Novick D; Peskind R L; Shenkar R; Gu Y; Su M S; Dinarello C A
Interleukin 18 stimulates HIV type 1 in monocytic cells.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(21):12550-5.
1998: Dinarello C A
Interleukin-1 beta, interleukin-18, and the interleukin-1 beta converting enzyme.
Annals of the New York Academy of Sciences 1998;856():1-11.
1998: Rubinstein M; Dinarello C A; Oppenheim J J; Hertzog P
Recent advances in cytokines, cytokine receptors and signal transduction.
Cytokine & growth factor reviews 1998;9(2):175-81.
1998: Shapiro L; Heidenreich K A; Meintzer M K; Dinarello C A
Role of p38 mitogen-activated protein kinase in HIV type 1 production in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(13):7422-6.
1998: Dinarello C A; Novick D; Puren A J; Fantuzzi G; Shapiro L; Mühl H; Yoon D Y; Reznikov L L; Kim S H; Rubinstein M
Overview of interleukin-18: more than an interferon-gamma inducing factor.
Journal of leukocyte biology 1998;63(6):658-64.
1998: Yoon D Y; Dinarello C A
Antibodies to domains II and III of the IL-1 receptor accessory protein inhibit IL-1 beta activity but not binding: regulation of IL-1 responses is via type I receptor, not the accessory protein.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(7):3170-9.
1998: Fantuzzi G; Dinarello C A
Stem cell factor-deficient mice have a dysregulation of cytokine production during local inflammation.
European cytokine network 1998;9(1):85-92.
1998: Fantuzzi G; Puren A J; Harding M W; Livingston D J; Dinarello C A
Interleukin-18 regulation of interferon gamma production and cell proliferation as shown in interleukin-1beta-converting enzyme (caspase-1)-deficient mice.
Blood 1998;91(6):2118-25.
1998: Puren A J; Fantuzzi G; Gu Y; Su M S; Dinarello C A
Interleukin-18 (IFNgamma-inducing factor) induces IL-8 and IL-1beta via TNFalpha production from non-CD14+ human blood mononuclear cells.
The Journal of clinical investigation 1998;101(3):711-21.
1998: Dinarello C A
Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist.
International reviews of immunology 1998;16(5-6):457-99.
1997: Dinarello C A
Interleukin-1.
Cytokine & growth factor reviews 1997;8(4):253-65.
1997: Dinarello C A
Proinflammatory and anti-inflammatory cytokines as mediators in the pathogenesis of septic shock.
Chest 1997;112(6 Suppl):321S-329S.
1997: Mühl H; Dinarello C A
Macrophage inflammatory protein-1 alpha production in lipopolysaccharide-stimulated human adherent blood mononuclear cells is inhibited by the nitric oxide synthase inhibitor N(G)-monomethyl-L-arginine.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(10):5063-9.
1997: van Deuren M; van der Ven-Jongekrijg J; Vannier E; van Dalen R; Pesman G; Bartelink A K; Dinarello C A; van der Meer J W
The pattern of interleukin-1beta (IL-1beta) and its modulating agents IL-1 receptor antagonist and IL-1 soluble receptor type II in acute meningococcal infections.
Blood 1997;90(3):1101-8.
1997: Fantuzzi G; Sacco S; Ghezzi P; Dinarello C A
Physiological and cytokine responses in IL-1 beta-deficient mice after zymosan-induced inflammation.
The American journal of physiology 1997;273(1 Pt 2):R400-6.
1997: Dinarello C A; Bunn P A
Fever.
Seminars in oncology 1997;24(3):288-98.
1997: Dinarello C A
Induction of interleukin-1 and interleukin-1 receptor antagonist.
Seminars in oncology 1997;24(3 Suppl 9):S9-81-S9-93.
1997: Kaplanski G; Fabrigoule M; Boulay V; Dinarello C A; Bongrand P; Kaplanski S; Farnarier C
Thrombin induces endothelial type II activation in vitro: IL-1 and TNF-alpha-independent IL-8 secretion and E-selectin expression.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(11):5435-41.
1997: Le Tulzo Y; Shenkar R; Kaneko D; Moine P; Fantuzzi G; Dinarello C A; Abraham E
Hemorrhage increases cytokine expression in lung mononuclear cells in mice: involvement of catecholamines in nuclear factor-kappaB regulation and cytokine expression.
The Journal of clinical investigation 1997;99(7):1516-24.
1997: Shapiro L; Dinarello C A
Hyperosmotic stress as a stimulant for proinflammatory cytokine production.
Experimental cell research 1997;231(2):354-62.
1997: Fantuzzi G; Ku G; Harding M W; Livingston D J; Sipe J D; Kuida K; Flavell R A; Dinarello C A
Response to local inflammation of IL-1 beta-converting enzyme- deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(4):1818-24.
1997: Aiura K; Clark B D; Dinarello C A; Margolis N H; Kaplanski G; Burke J F; Tompkins R G; Gelfand J A
Interaction with autologous platelets multiplies interleukin-1 and tumor necrosis factor production in mononuclear cells.
The Journal of infectious diseases 1997;175(1):123-9.
1996: Pereira B J; Sundaram S; Barrett T W; Butt N K; Porat R; King A J; Dinarello C A
Transfer of cytokine-inducing bacterial products across hemodialyzer membranes in the presence of plasma or whole blood.
Clinical nephrology 1996;46(6):394-401.
1996: Clark B D; Ikejima T; Mancilla J; Orencole S F; Sirko S P; Ishii N; Okuda K; Dinarello C A
An antibody to a 17 amino acid synthetic peptide of the type I interleukin-1 receptor preferentially blocks interleukin-1 beta binding.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1996;16(12):1079-88.
1996: Fuchs A C; Granowitz E V; Shapiro L; Vannier E; Lonnemann G; Angel J B; Kennedy J S; Rabson A R; Radwanski E; Affrime M B; Cutler D L; Grint P C; Dinarello C A
Clinical, hematologic, and immunologic effects of interleukin-10 in humans.
Journal of clinical immunology 1996;16(5):291-303.
1996: Fantuzzi G; Zheng H; Faggioni R; Benigni F; Ghezzi P; Sipe J D; Shaw A R; Dinarello C A
Effect of endotoxin in IL-1 beta-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(1):291-6.
1996: Ye K; Vannier E; Clark B D; Sims J E; Dinarello C A
Three distinct promoters direct transcription of different 5' untranslated regions of the human interleukin 1 type I receptor: a possible mechanism for control of translation.
Cytokine 1996;8(6):421-9.
1996: Dinarello C A
Thermoregulation and the pathogenesis of fever.
Infectious disease clinics of North America 1996;10(2):433-49.
1996: Takabayashi T; Vannier E; Clark B D; Margolis N H; Dinarello C A; Burke J F; Gelfand J A
A new biologic role for C3a and C3a desArg: regulation of TNF-alpha and IL-1 beta synthesis.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(9):3455-60.
1996: Fantuzzi G; Dinarello C A
The inflammatory response in interleukin-1 beta-deficient mice: comparison with other cytokine-related knock-out mice.
Journal of leukocyte biology 1996;59(4):489-93.
1996: Granowitz E V; Saget B M; Angel J B; Wang M Z; Wang A; Dinarello C A; Skolnik P R
Soluble tumor necrosis factor receptors inhibit phorbol myristate acetate and cytokine-induced HIV-1 expression chronically infected U1 cells.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1996;11(5):430-7.
1996: Benigni F; Fantuzzi G; Sacco S; Sironi M; Pozzi P; Dinarello C A; Sipe J D; Poli V; Cappelletti M; Paonessa G; Pennica D; Panayotatos N; Ghezzi P
Six different cytokines that share GP130 as a receptor subunit, induce serum amyloid A and potentiate the induction of interleukin-6 and the activation of the hypothalamus-pituitary-adrenal axis by interleukin-1.
Blood 1996;87(5):1851-4.
1996: Dinarello C A
Biologic basis for interleukin-1 in disease.
Blood 1996;87(6):2095-147.
1996: Endres S; Whitaker R E; Ghorbani R; Meydani S N; Dinarello C A
Oral aspirin and ibuprofen increase cytokine-induced synthesis of IL-1 beta and of tumour necrosis factor-alpha ex vivo.
Immunology 1996;87(2):264-70.
1996: Dinarello C A; Roubenoff R A
Mechanisms of loss of lean body mass in patients on chronic dialysis.
Blood purification 1996;14(5):388-94.
1996: Dinarello C A
Cytokines as mediators in the pathogenesis of septic shock.
Current topics in microbiology and immunology 1996;216():133-65.
1995: Kaplanski G; Teysseire N; Farnarier C; Kaplanski S; Lissitzky J C; Durand J M; Soubeyrand J; Dinarello C A; Bongrand P
IL-6 and IL-8 production from cultured human endothelial cells stimulated by infection with Rickettsia conorii via a cell-associated IL-1 alpha-dependent pathway.
The Journal of clinical investigation 1995;96(6):2839-44.
1995: Shapiro L; Dinarello C A
Osmotic regulation of cytokine synthesis in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(26):12230-4.
1995: Angel J B; Saget B M; Walsh S P; Greten T F; Dinarello C A; Skolnik P R; Endres S
Rolipram, a specific type IV phosphodiesterase inhibitor, is a potent inhibitor of HIV-1 replication.
AIDS (London, England) 1995;9(10):1137-44.
1995: Beasley D; McGuiggin M E; Dinarello C A
Human vascular smooth muscle cells produce an intracellular form of interleukin-1 receptor antagonist.
The American journal of physiology 1995;269(4 Pt 1):C961-8.
1995: Dinarello C A
Controlling the production of interleukin-1 and tumor necrosis factor in disease.
Nutrition (Burbank, Los Angeles County, Calif.) 1995;11(5 Suppl):695-7.
1995: Dinarello C A
Interleukin-1 and interleukin-1 receptor antagonist.
Nutrition (Burbank, Los Angeles County, Calif.) 1995;11(5 Suppl):492-4.
1995: Granowitz E V; Saget B M; Wang M Z; Dinarello C A; Skolnik P R
Interleukin 1 induces HIV-1 expression in chronically infected U1 cells: blockade by interleukin 1 receptor antagonist and tumor necrosis factor binding protein type 1.
Molecular medicine (Cambridge, Mass.) 1995;1(6):667-77.
1995: Miller L C; Sharma A; McKusick A F; Tassoni J P; Dinarello C A; Kaplan M M
Synthesis of interleukin-1 beta in primary biliary cirrhosis: relationship to treatment with methotrexate or colchicine and disease progression.
Hepatology (Baltimore, Md.) 1995;22(2):518-24.
1995: Mileno M D; Margolis N H; Clark B D; Dinarello C A; Burke J F; Gelfand J A
Coagulation of whole blood stimulates interleukin-1 beta gene expression.
The Journal of infectious diseases 1995;172(1):308-11.
1995: Angel J B; Saget B M; Wang M Z; Wang A; Dinarello C A; Skolnik P R
Interleukin-10 enhances human immunodeficiency virus type 1 expression in a chronically infected promonocytic cell line (U1) by a tumor necrosis factor alpha-independent mechanism.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1995;15(6):575-84.
1995: Dinarello C A; Margolis N H
Cytokine-processing enzymes. Stopping the cuts.
Current biology : CB 1995;5(6):587-90.
1995: Chernoff A E; Granowitz E V; Shapiro L; Vannier E; Lonnemann G; Angel J B; Kennedy J S; Rabson A R; Wolff S M; Dinarello C A
A randomized, controlled trial of IL-10 in humans. Inhibition of inflammatory cytokine production and immune responses.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(10):5492-9.
1995: Lonnemann G; Engler-Blum G; Müller G A; Koch K M; Dinarello C A
Cytokines in human renal interstitial fibrosis. II. Intrinsic interleukin (IL)-1 synthesis and IL-1-dependent production of IL-6 and IL-8 by cultured kidney fibroblasts.
Kidney international 1995;47(3):845-54.
1995: Lonnemann G; Shapiro L; Engler-Blum G; Müller G A; Koch K M; Dinarello C A
Cytokines in human renal interstitial fibrosis. I. Interleukin-1 is a paracrine growth factor for cultured fibrosis-derived kidney fibroblasts.
Kidney international 1995;47(3):837-44.
1995: Fantuzzi G; Benigni F; Sironi M; Conni M; Carelli M; Cantoni L; Shapiro L; Dinarello C A; Sipe J D; Ghezzi P
Ciliary neurotrophic factor (CNTF) induces serum amyloid A, hypoglycaemia and anorexia, and potentiates IL-1 induced corticosterone and IL-6 production in mice.
Cytokine 1995;7(2):150-6.
1995: Dinarello C A
Interleukin-1 and interleukin-1 receptor antagonist production during haemodialysis: which cytokine is a surrogate marker for dialysis-related complications?
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1995;10 Suppl 3():25-8.
1994: Dinarello C A
The interleukin-1 family: 10 years of discovery.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1994;8(15):1314-25.
1994: Kaplanski G; Farnarier C; Kaplanski S; Porat R; Shapiro L; Bongrand P; Dinarello C A
Interleukin-1 induces interleukin-8 secretion from endothelial cells by a juxtacrine mechanism.
Blood 1994;84(12):4242-8.
1994: Shapiro L; Panayotatos N; Meydani S N; Wu D; Dinarello C A
Ciliary neurotrophic factor combined with soluble receptor inhibits synthesis of proinflammatory cytokines and prostaglandin-E2 in vitro.
Experimental cell research 1994;215(1):51-6.
1994: Dinarello C A
The biological properties of interleukin-1.
European cytokine network 1994;5(6):517-31.
1994: Dinarello C A
Interleukin-1 in disease.
The Keio journal of medicine 1994;43(3):131-6.
1994: Santos A A; Rodrick M L; Jacobs D O; Dinarello C A; Wolff S M; Mannick J A; Wilmore D W
Does the route of feeding modify the inflammatory response?
Annals of surgery 1994;220(2):155-63.
1994: Lynch E A; Dinarello C A; Cannon J G
Gender differences in IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist secretion from mononuclear cells and urinary excretion.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(1):300-6.
1994: Wakabayashi G; Cannon J G; Gelfand J A; Clark B D; Aiura K; Burke J F; Wolff S M; Dinarello C A
Altered interleukin-1 and tumor necrosis factor production and secretion during pyrogenic tolerance to LPS in rabbits.
The American journal of physiology 1994;267(1 Pt 2):R329-36.
1994: Dinarello C A
Is there a role for interleukin-1 blockade in intravenous immunoglobulin therapy?
Immunological reviews 1994;139():173-88.
1994: Vannier E; Dinarello C A
Histamine enhances interleukin (IL)-1-induced IL-6 gene expression and protein synthesis via H2 receptors in peripheral blood mononuclear cells.
The Journal of biological chemistry 1994;269(13):9952-6.
1994: Pereira B J; Shapiro L; King A J; Falagas M E; Strom J A; Dinarello C A
Plasma levels of IL-1 beta, TNF alpha and their specific inhibitors in undialyzed chronic renal failure, CAPD and hemodialysis patients.
Kidney international 1994;45(3):890-6.
1994: Tilg H; Shapiro L; Vannier E; Poutsiaka D D; Trehu E; Atkins M B; Dinarello C A; Mier J W
Induction of circulating antagonists to IL-1 and TNF by IL-2 administration and their effects on IL-2 induced cytokine production in vitro.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(6):3189-98.
1994: Tilg H; Trehu E; Shapiro L; Pape D; Atkins M B; Dinarello C A; Mier J W
Induction of circulating soluble tumour necrosis factor receptor and interleukin 1 receptor antagonist following interleukin 1 alpha infusion in humans.
Cytokine 1994;6(2):215-9.
1994: Santos A A; Browning J L; Scheltinga M R; Lynch E A; Brown E F; Lawton P; Chambers E; Dougas I; Benjamin C D; Dinarello C A
Are events after endotoxemia related to circulating phospholipase A2?
Annals of surgery 1994;219(2):183-92.
1994: Granowitz E V; Porat R; Gelfand J A; Wolff S M; Dinarello C A
Administration of low-dose endotoxin to healthy humans increases C5a binding to circulating neutrophils.
The Journal of infectious diseases 1994;169(2):480-2.
1994: Tilg H; Trehu E; Atkins M B; Dinarello C A; Mier J W
Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55.
Blood 1994;83(1):113-8.
1994: Latini R; Bianchi M; Correale E; Dinarello C A; Fantuzzi G; Fresco C; Maggioni A P; Mengozzi M; Romano S; Shapiro L
Cytokines in acute myocardial infarction: selective increase in circulating tumor necrosis factor, its soluble receptor, and interleukin-1 receptor antagonist.
Journal of cardiovascular pharmacology 1994;23(1):1-6.
1994: Dinarello C A
Interleukin-1.
Advances in pharmacology (San Diego, Calif.) 1994;25():21-51.
1994: Pereira B J; Dinarello C A
Production of cytokines and cytokine inhibitory proteins in patients on dialysis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1994;9 Suppl 2():60-71.
1994: Pereira B J; King A J; Falagas M E; Dinarello C A
Interleukin-1 receptor antagonist: an index of dialysis-induced interleukin-1 production.
Nephron 1994;67(3):358-61.
1994: Dinarello C A
Blocking interleukin-1 receptors.
International journal of clinical & laboratory research 1994;24(2):61-79.
1993: Endres S; Meydani S N; Ghorbani R; Schindler R; Dinarello C A
Dietary supplementation with n-3 fatty acids suppresses interleukin-2 production and mononuclear cell proliferation.
Journal of leukocyte biology 1993;54(6):599-603.
1993: Poutsiaka D D; Mengozzi M; Vannier E; Sinha B; Dinarello C A
Cross-linking of the beta-glucan receptor on human monocytes results in interleukin-1 receptor antagonist but not interleukin-1 production.
Blood 1993;82(12):3695-700.
1993: Tilg H; Vogel W; Wiedermann C J; Shapiro L; Herold M; Judmaier G; Dinarello C A
Circulating interleukin-1 and tumor necrosis factor antagonists in liver disease.
Hepatology (Baltimore, Md.) 1993;18(5):1132-8.
1993: Tilg H; Vannier E; Vachino G; Dinarello C A; Mier J W
Antiinflammatory properties of hepatic acute phase proteins: preferential induction of interleukin 1 (IL-1) receptor antagonist over IL-1 beta synthesis by human peripheral blood mononuclear cells.
The Journal of experimental medicine 1993;178(5):1629-36.
1993: Erroi A; Fantuzzi G; Mengozzi M; Sironi M; Orencole S F; Clark B D; Dinarello C A; Isetta A; Gnocchi P; Giovarelli M
Differential regulation of cytokine production in lipopolysaccharide tolerance in mice.
Infection and immunity 1993;61(10):4356-9.
1993: Cannon J G; Nerad J L; Poutsiaka D D; Dinarello C A
Measuring circulating cytokines.
Journal of applied physiology (Bethesda, Md. : 1985) 1993;75(4):1897-902.
1993: Tilg H; Pape D; Trehu E; Shapiro L; Atkins M B; Dinarello C A; Mier J W
A method for the detection of erythrocyte-bound interleukin-8 in humans during interleukin-1 immunotherapy.
Journal of immunological methods 1993;163(2):253-8.
1993: Pereira B J; King A J; Poutsiaka D D; Strom J A; Dinarello C A
Comparison of first use and reuse of cuprophan membranes on interleukin-1 receptor antagonist and interleukin-1 beta production by blood mononuclear cells.
American journal of kidney diseases : the official journal of the National Kidney Foundation 1993;22(2):288-95.
1993: Aiura K; Gelfand J A; Burke J F; Thompson R C; Dinarello C A
Interleukin-1 (IL-1) receptor antagonist prevents Staphylococcus epidermidis-induced hypotension and reduces circulating levels of tumor necrosis factor and IL-1 beta in rabbits.
Infection and immunity 1993;61(8):3342-50.
1993: Granowitz E V; Porat R; Mier J W; Orencole S F; Kaplanski G; Lynch E A; Ye K; Vannier E; Wolff S M; Dinarello C A
Intravenous endotoxin suppresses the cytokine response of peripheral blood mononuclear cells of healthy humans.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(3):1637-45.
1993: Vannier E; Dinarello C A
Histamine enhances interleukin (IL)-1-induced IL-1 gene expression and protein synthesis via H2 receptors in peripheral blood mononuclear cells. Comparison with IL-1 receptor antagonist.
The Journal of clinical investigation 1993;92(1):281-7.
1993: Dinarello C A
Modalities for reducing interleukin 1 activity in disease.
Immunology today 1993;14(6):260-4.
1993: Shapiro L; Clark B D; Orencole S F; Poutsiaka D D; Granowitz E V; Dinarello C A
Detection of tumor necrosis factor soluble receptor p55 in blood samples from healthy and endotoxemic humans.
The Journal of infectious diseases 1993;167(6):1344-50.
1993: Kaplanski G; Porat R; Aiura K; Erban J K; Gelfand J A; Dinarello C A
Activated platelets induce endothelial secretion of interleukin-8 in vitro via an interleukin-1-mediated event.
Blood 1993;81(10):2492-5.
1993: Tilg H; Mier J W; Vogel W; Aulitzky W E; Wiedermann C J; Vannier E; Huber C; Dinarello C A
Induction of circulating IL-1 receptor antagonist by IFN treatment.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(10):4687-92.
1993: Coceani F; Lees J; Mancilla J; Belizario J; Dinarello C A
Interleukin-6 and tumor necrosis factor in cerebrospinal fluid: changes during pyrogen fever.
Brain research 1993;612(1-2):165-71.
1993: Dinarello C A
Modalities for reducing interleukin 1 activity in disease.
Trends in pharmacological sciences 1993;14(5):155-9.
1993: Dinarello C A; Gelfand J A; Wolff S M
Anticytokine strategies in the treatment of the systemic inflammatory response syndrome.
JAMA : the journal of the American Medical Association 1993;269(14):1829-35.
1993: Ye K; Dinarello C A; Clark B D
Identification of the promoter region of human interleukin 1 type I receptor gene: multiple initiation sites, high G+C content, and constitutive expression.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(6):2295-9.
1993: Schindler R; Linnenweber S; Schulze M; Oppermann M; Dinarello C A; Shaldon S; Koch K M
Gene expression of interleukin-1 beta during hemodialysis.
Kidney international 1993;43(3):712-21.
1993: Mancilla J; García P; Dinarello C A
The interleukin-1 receptor antagonist can either reduce or enhance the lethality of Klebsiella pneumoniae sepsis in newborn rats.
Infection and immunity 1993;61(3):926-32.
1993: Santos A A; Scheltinga M R; Lynch E; Brown E F; Lawton P; Chambers E; Browning J; Dinarello C A; Wolff S M; Wilmore D W
Elaboration of interleukin 1-receptor antagonist is not attenuated by glucocorticoids after endotoxemia.
Archives of surgery (Chicago, Ill. : 1960) 1993;128(2):138-43; discussion 143-4.
1993: Dinarello C A; Wolff S M
The role of interleukin-1 in disease.
The New England journal of medicine 1993;328(2):106-13.
1993: Miller L C; Lynch E A; Isa S; Logan J W; Dinarello C A; Steere A C
Balance of synovial fluid IL-1 beta and IL-1 receptor antagonist and recovery from Lyme arthritis.
Lancet 1993;341(8838):146-8.
1993: Dinarello C A
Blocking interleukin-1 in disease.
Blood purification 1993;11(2):118-27.
1992: Pereira B J; Poutsiaka D D; King A J; Strom J A; Narayan G; Levey A S; Dinarello C A
In vitro production of interleukin-1 receptor antagonist in chronic renal failure, CAPD and HD.
Kidney international 1992;42(6):1419-24.
1992: Nerad J L; Griffiths J K; Van der Meer J W; Endres S; Poutsiaka D D; Keusch G T; Bennish M; Salam M A; Dinarello C A; Cannon J G
Interleukin-1 beta (IL-1 beta), IL-1 receptor antagonist, and TNF alpha production in whole blood.
Journal of leukocyte biology 1992;52(6):687-92.
1992: Granowitz E V; Porat R; Orencole S F; Callahan M V; Lynch E A; Wolff S M; Dinarello C A
Granulocyte-macrophage colony-stimulating factor synthesis during experimental endotoxemia in humans.
The Journal of infectious diseases 1992;166(5):1204-5.
1992: Numerof R P; Sipe J D; Trehu E G; Dinarello C A; Mier J W
Suppression of IL-2-induced SAA gene expression in mice by the administration of an IL-1 receptor antagonist.
Cytokine 1992;4(6):555-60.
1992: Dinarello C A
The role of interleukin-1 in host responses to infectious diseases.
Infectious agents and disease 1992;1(5):227-36.
1992: Dinarello C A
Interleukin-1 and tumor necrosis factor and their naturally occurring antagonists during hemodialysis.
Kidney international. Supplement 1992;38():S68-77.
1992: Granowitz E V; Porat R; Mier J W; Pribble J P; Stiles D M; Bloedow D C; Catalano M A; Wolff S M; Dinarello C A
Pharmacokinetics, safety and immunomodulatory effects of human recombinant interleukin-1 receptor antagonist in healthy humans.
Cytokine 1992;4(5):353-60.
1992: Miller L C; Isa S; Vannier E; Georgilis K; Steere A C; Dinarello C A
Live Borrelia burgdorferi preferentially activate interleukin-1 beta gene expression and protein synthesis over the interleukin-1 receptor antagonist.
The Journal of clinical investigation 1992;90(3):906-12.
1992: Mancilla J; Ikejima T; Dinarello C A
Glycosylation of the interleukin-1 receptor type I is required for optimal binding of interleukin-1.
Lymphokine and cytokine research 1992;11(4):197-205.
1992: Katzen N A; Segal G M; Vannier E; Nerad J L; Klempner M S; Dinarello C A
Comparison of granulocyte-macrophage colony stimulating factor and interleukin-1 production from human peripheral blood mononuclear cells as measured by specific radioimmunoassays.
European cytokine network 1992;3(4):365-72.
1992: Dinarello C A
Dissociation of transcription from translation of human IL-1 beta: induction of steady state mRNA by adherence or recombinant C5a in the absence of translation.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1992;200(2):228-32.
1992: Dinarello C A
Role of interleukin-1 in infectious diseases.
Immunological reviews 1992;127():119-46.
1992: Dinarello C A
Interleukin-1 and tumor necrosis factor: effector cytokines in autoimmune diseases.
Seminars in immunology 1992;4(3):133-45.
1992: Granowitz E V; Vannier E; Poutsiaka D D; Dinarello C A
Effect of interleukin-1 (IL-1) blockade on cytokine synthesis: II. IL-1 receptor antagonist inhibits lipopolysaccharide-induced cytokine synthesis by human monocytes.
Blood 1992;79(9):2364-9.
1992: Granowitz E V; Clark B D; Vannier E; Callahan M V; Dinarello C A
Effect of interleukin-1 (IL-1) blockade on cytokine synthesis: I. IL-1 receptor antagonist inhibits IL-1-induced cytokine synthesis and blocks the binding of IL-1 to its type II receptor on human monocytes.
Blood 1992;79(9):2356-63.
1992: Vannier E; Miller L C; Dinarello C A
Coordinated antiinflammatory effects of interleukin 4: interleukin 4 suppresses interleukin 1 production but up-regulates gene expression and synthesis of interleukin 1 receptor antagonist.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(9):4076-80.
1992: Dinarello C A
ELISA kits based on monoclonal antibodies do not measure total IL-1 beta synthesis.
Journal of immunological methods 1992;148(1-2):255-9.
1992: Porat R; Poutsiaka D D; Miller L C; Granowitz E V; Dinarello C A
Interleukin-1 (IL-1) receptor blockade reduces endotoxin and Borrelia burgdorferi-stimulated IL-8 synthesis in human mononuclear cells.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1992;6(7):2482-6.
1992: Ye K; Koch K C; Clark B D; Dinarello C A
Interleukin-1 down-regulates gene and surface expression of interleukin-1 receptor type I by destabilizing its mRNA whereas interleukin-2 increases its expression.
Immunology 1992;75(3):427-34.
1992: Dinarello C A
Anti-cytokine strategies.
European cytokine network 1992;3(1):7-17.
1992: Koch K C; Ye K; Clark B D; Dinarello C A
Interleukin 4 (IL) 4 up-regulates gene and surface IL 1 receptor type I in murine T helper type 2 cells.
European journal of immunology 1992;22(1):153-7.
1992: Dinarello C A
The biology of interleukin-1.
Chemical immunology 1992;51():1-32.
1992: Dinarello C A
Reduction of inflammation by decreasing production of interleukin-1 or by specific receptor antagonism.
International journal of tissue reactions 1992;14(2):65-75.
1991: Clark B D; Bedrosian I; Schindler R; Cominelli F; Cannon J G; Shaw A R; Dinarello C A
Detection of interleukin 1 alpha and 1 beta in rabbit tissues during endotoxemia using sensitive radioimmunoassays.
Journal of applied physiology (Bethesda, Md. : 1985) 1991;71(6):2412-8.
1991: Granowitz E V; Santos A A; Poutsiaka D D; Cannon J G; Wilmore D W; Wolff S M; Dinarello C A
Production of interleukin-1-receptor antagonist during experimental endotoxaemia.
Lancet 1991;338(8780):1423-4.
1991: Bedrosian I; Sofia R D; Wolff S M; Dinarello C A
Taurolidine, an analogue of the amino acid taurine, suppresses interleukin 1 and tumor necrosis factor synthesis in human peripheral blood mononuclear cells.
Cytokine 1991;3(6):568-75.
1991: Porat R; Clark B D; Wolff S M; Dinarello C A
Enhancement of growth of virulent strains of Escherichia coli by interleukin-1.
Science (New York, N.Y.) 1991;254(5030):430-2.
1991: Dinarello C A; Cannon J G; Mancilla J; Bishai I; Lees J; Coceani F
Interleukin-6 as an endogenous pyrogen: induction of prostaglandin E2 in brain but not in peripheral blood mononuclear cells.
Brain research 1991;562(2):199-206.
1991: Poutsiaka D D; Clark B D; Vannier E; Dinarello C A
Production of interleukin-1 receptor antagonist and interleukin-1 beta by peripheral blood mononuclear cells is differentially regulated.
Blood 1991;78(5):1275-81.
1991: Granowitz E V; Clark B D; Mancilla J; Dinarello C A
Interleukin-1 receptor antagonist competitively inhibits the binding of interleukin-1 to the type II interleukin-1 receptor.
The Journal of biological chemistry 1991;266(22):14147-50.
1991: Vannier E; Miller L C; Dinarello C A
Histamine suppresses gene expression and synthesis of tumor necrosis factor alpha via histamine H2 receptors.
The Journal of experimental medicine 1991;174(1):281-4.
1991: Wakabayashi G; Gelfand J A; Jung W K; Connolly R J; Burke J F; Dinarello C A
Staphylococcus epidermidis induces complement activation, tumor necrosis factor and interleukin-1, a shock-like state and tissue injury in rabbits without endotoxemia. Comparison to Escherichia coli.
The Journal of clinical investigation 1991;87(6):1925-35.
1991: Dinarello C A
The proinflammatory cytokines interleukin-1 and tumor necrosis factor and treatment of the septic shock syndrome.
The Journal of infectious diseases 1991;163(6):1177-84.
1991: Belizario J E; Dinarello C A
Interleukin 1, interleukin 6, tumor necrosis factor, and transforming growth factor beta increase cell resistance to tumor necrosis factor cytotoxicity by growth arrest in the G1 phase of the cell cycle.
Cancer research 1991;51(9):2379-85.
1991: Dinarello C A
Interleukin-1 and interleukin-1 antagonism.
Blood 1991;77(8):1627-52.
1991: Wakabayashi G; Gelfand J A; Burke J F; Thompson R C; Dinarello C A
A specific receptor antagonist for interleukin 1 prevents Escherichia coli-induced shock in rabbits.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1991;5(3):338-43.
1991: Morin M; Schindler R; Wakabayashi G; Daumy G; Dinarello C A; Gelfand J A
Picogram concentrations of endotoxin stimulate synthesis of IL-1 beta and TNF alpha by human peripheral blood mononuclear cells exposed to recombinant human C5a.
European cytokine network 1991;2(1):27-30.
1990: Schindler R; Gelfand J A; Dinarello C A
Recombinant C5a stimulates transcription rather than translation of interleukin-1 (IL-1) and tumor necrosis factor: translational signal provided by lipopolysaccharide or IL-1 itself.
Blood 1990;76(8):1631-8.
1990: Numerof R P; Kotik A N; Dinarello C A; Mier J W
Pro-interleukin-1 beta production by a subpopulation of human T cells, but not NK cells, in response to interleukin-2.
Cellular immunology 1990;130(1):118-28.
1990: Ikejima T; Okusawa S; Ghezzi P; van der Meer J W; Dinarello C A
Interleukin-1 induces tumor necrosis factor (TNF) in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits.
The Journal of infectious diseases 1990;162(1):215-23.
1990: Schindler R; Clark B D; Dinarello C A
Dissociation between interleukin-1 beta mRNA and protein synthesis in human peripheral blood mononuclear cells.
The Journal of biological chemistry 1990;265(18):10232-7.
1990: Koenig J I; Snow K; Clark B D; Toni R; Cannon J G; Shaw A R; Dinarello C A; Reichlin S; Lee S L; Lechan R M
Intrinsic pituitary interleukin-1 beta is induced by bacterial lipopolysaccharide.
Endocrinology 1990;126(6):3053-8.
1990: Lechan R M; Toni R; Clark B D; Cannon J G; Shaw A R; Dinarello C A; Reichlin S
Immunoreactive interleukin-1 beta localization in the rat forebrain.
Brain research 1990;514(1):135-40.
1990: Dinarello C A; Clark B D; Ikejima T; Puren A J; Savage N; Rosoff P M
Interleukin 1 receptors and biological responses.
The Yale journal of biology and medicine 1990;63(2):87-93.
1990: Schindler R; Ghezzi P; Dinarello C A
IL-1 induces IL-1. IV. IFN-gamma suppresses IL-1 but not lipopolysaccharide-induced transcription of IL-1.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(6):2216-22.
1990: Schindler R; Lonnemann G; Shaldon S; Koch K M; Dinarello C A
Transcription, not synthesis, of interleukin-1 and tumor necrosis factor by complement.
Kidney international 1990;37(1):85-93.
1990: Schindler R; Mancilla J; Endres S; Ghorbani R; Clark S C; Dinarello C A
Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF.
Blood 1990;75(1):40-7.
1990: Dinarello C A; Schindler R
Dissociation of transcription from translation of human IL-1-beta: the induction of steady state mRNA by adherence or recombinant C5a in the absence of translation.
Progress in clinical and biological research 1990;349():195-204.
1990: Dinarello C A; Endres S; Meydani S N; Meydani M; Hellerstein M K
Interleukin-1, anorexia, and dietary fatty acids.
Annals of the New York Academy of Sciences 1990;587():332-8.
1990: Dinarello C A
Cytokines and biocompatibility.
Blood purification 1990;8(4):208-13.
1990: Dinarello C A
Interleukin-1 and inhibition of interleukin-1 in hemodialysis patients.
Contributions to nephrology 1990;86():48-69; discussion 69-72.
1989: Endres S; Cannon J G; Ghorbani R; Dempsey R A; Sisson S D; Lonnemann G; Van der Meer J W; Wolff S M; Dinarello C A
In vitro production of IL 1 beta, IL 1 alpha, TNF and IL2 in healthy subjects: distribution, effect of cyclooxygenase inhibition and evidence of independent gene regulation.
European journal of immunology 1989;19(12):2327-33.
1989: Savage N; Puren A J; Orencole S F; Ikejima T; Clark B D; Dinarello C A
Studies on IL-1 receptors on D10S T-helper cells: demonstration of two molecularly and antigenically distinct IL-1 binding proteins.
Cytokine 1989;1(1):23-35.
1989: Orencole S F; Dinarello C A
Characterization of a subclone (D10S) of the D10.G4.1 helper T-cell line which proliferates to attomolar concentrations of interleukin-1 in the absence of mitogens.
Cytokine 1989;1(1):14-22.
1989: Lonnemann G; Endres S; Van der Meer J W; Cannon J G; Koch K M; Dinarello C A
Differences in the synthesis and kinetics of release of interleukin 1 alpha, interleukin 1 beta and tumor necrosis factor from human mononuclear cells.
European journal of immunology 1989;19(9):1531-6.
1989: Cannon J G; Fielding R A; Fiatarone M A; Orencole S F; Dinarello C A; Evans W J
Increased interleukin 1 beta in human skeletal muscle after exercise.
The American journal of physiology 1989;257(2 Pt 2):R451-5.
1989: Whitcomb E A; Dinarello C A; Pincus S H
Differential effects of interleukin-1 alpha and interleukin-1 beta on human peripheral blood eosinophils.
Blood 1989;73(7):1904-8.
1989: Cannon J G; Clark B D; Wingfield P; Schmeissner U; Losberger C; Dinarello C A; Shaw A R
Rabbit IL-1. Cloning, expression, biologic properties, and transcription during endotoxemia.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(7):2299-306.
1989: Prakash S; Dinarello C A; Danko K; Stadecker M J; Wyler D J
Schistosomal egg granuloma-derived fibroblast-stimulating factor is apparently distinct from interleukin-1.
Infection and immunity 1989;57(3):679-84.
1989: Dinarello C A; Clark B D; Puren A J; Savage N; Rosoff P M
The interleukin 1 receptor.
Immunology today 1989;10(2):49-51.
1989: Schindler R; Dinarello C A
A method for removing interleukin-1- and tumor necrosis factor-inducing substances from bacterial cultures by ultrafiltration with polysulfone.
Journal of immunological methods 1989;116(2):159-65.
1989: Scarborough D E; Lee S L; Dinarello C A; Reichlin S
Interleukin-1 beta stimulates somatostatin biosynthesis in primary cultures of fetal rat brain.
Endocrinology 1989;124(1):549-51.
1989: Dinarello C A; Okusawa S; Gelfand J A
Interleukin-1 induces a shock-like state in rabbits: synergism with tumor necrosis factor and the effect of ibuprofen.
Progress in clinical and biological research 1989;299():203-15.
1989: Dinarello C A; Orencole S F; Savage N
Interleukin-1 induced T-lymphocyte proliferation and its relation to IL-1 receptors.
Advances in experimental medicine and biology 1989;254():45-53.
1989: Dinarello C A; Okusawa S; Gelfand J A
Interleukin-1 induces a shock-like state in rabbits: synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition.
Progress in clinical and biological research 1989;286():243-63.
1989: Schindler R; Ghezzi P; Dinarello C A
Interferons as inhibitors of interleukin 1 induced interleukin 1 synthesis.
Lymphokine research 1989;8(3):275-80.
1989: Dinarello C A
Interleukin-1 and its biologically related cytokines.
Advances in immunology 1989;44():153-205.
1988: Tredget E E; Yu Y M; Zhong S; Burini R; Okusawa S; Gelfand J A; Dinarello C A; Young V R; Burke J F
Role of interleukin 1 and tumor necrosis factor on energy metabolism in rabbits.
The American journal of physiology 1988;255(6 Pt 1):E760-8.
1988: Endres S; Ghorbani R; Lonnemann G; van der Meer J W; Dinarello C A
Measurement of immunoreactive interleukin-1 beta from human mononuclear cells: optimization of recovery, intrasubject consistency, and comparison with interleukin-1 alpha and tumor necrosis factor.
Clinical immunology and immunopathology 1988;49(3):424-38.
1988: Mier J W; Vachino G; van der Meer J W; Numerof R P; Adams S; Cannon J G; Bernheim H A; Atkins M B; Parkinson D R; Dinarello C A
Induction of circulating tumor necrosis factor (TNF alpha) as the mechanism for the febrile response to interleukin-2 (IL-2) in cancer patients.
Journal of clinical immunology 1988;8(6):426-36.
1988: Ikejima T; Okusawa S; van der Meer J W; Dinarello C A
Induction by toxic-shock-syndrome toxin-1 of a circulating tumor necrosis factor-like substance in rabbits and of immunoreactive tumor necrosis factor and interleukin-1 from human mononuclear cells.
The Journal of infectious diseases 1988;158(5):1017-25.
1988: Sisson S D; Dinarello C A
Production of interleukin-1 alpha, interleukin-1 beta and tumor necrosis factor by human mononuclear cells stimulated with granulocyte-macrophage colony-stimulating factor.
Blood 1988;72(4):1368-74.
1988: Michie H R; Spriggs D R; Manogue K R; Sherman M L; Revhaug A; O'Dwyer S T; Arthur K; Dinarello C A; Cerami A; Wolff S M
Tumor necrosis factor and endotoxin induce similar metabolic responses in human beings.
Surgery 1988;104(2):280-6.
1988: Okusawa S; Yancey K B; van der Meer J W; Endres S; Lonnemann G; Hefter K; Frank M M; Burke J F; Dinarello C A; Gelfand J A
C5a stimulates secretion of tumor necrosis factor from human mononuclear cells in vitro. Comparison with secretion of interleukin 1 beta and interleukin 1 alpha.
The Journal of experimental medicine 1988;168(1):443-8.
1988: Ghezzi P; Dinarello C A
IL-1 induces IL-1. III. Specific inhibition of IL-1 production by IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(12):4238-44.
1988: Michie H R; Manogue K R; Spriggs D R; Revhaug A; O'Dwyer S; Dinarello C A; Cerami A; Wolff S M; Wilmore D W
Detection of circulating tumor necrosis factor after endotoxin administration.
The New England journal of medicine 1988;318(23):1481-6.
1988: Coceani F; Lees J; Dinarello C A
Occurrence of interleukin-1 in cerebrospinal fluid of the conscious cat.
Brain research 1988;446(2):245-50.
1988: Okusawa S; Gelfand J A; Ikejima T; Connolly R J; Dinarello C A
Interleukin 1 induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition.
The Journal of clinical investigation 1988;81(4):1162-72.
1988: Dinarello C A; Koch K M; Shaldon S
Interleukin-1 and its relevance in patients treated with hemodialysis.
Kidney international. Supplement 1988;24():S21-6.
1988: van der Meer J W; Endres S; Lonnemann G; Cannon J G; Ikejima T; Okusawa S; Gelfand J A; Dinarello C A
Concentrations of immunoreactive human tumor necrosis factor alpha produced by human mononuclear cells in vitro.
Journal of leukocyte biology 1988;43(3):216-23.
1988: Dinarello C A
Interleukin-1.
Digestive diseases and sciences 1988;33(3 Suppl):25S-35S.
1988: van der Meer J W; Barza M; Wolff S M; Dinarello C A
A low dose of recombinant interleukin 1 protects granulocytopenic mice from lethal gram-negative infection.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(5):1620-3.
1988: Dinarello C A
Biology of interleukin 1.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1988;2(2):108-15.
1988: Revhaug A; Michie H R; Manson J M; Watters J M; Dinarello C A; Wolff S M; Wilmore D W
Inhibition of cyclo-oxygenase attenuates the metabolic response to endotoxin in humans.
Archives of surgery (Chicago, Ill. : 1960) 1988;123(2):162-70.
1988: Lonnemann G; Bingel M; Floege J; Koch K M; Shaldon S; Dinarello C A
Detection of endotoxin-like interleukin-1-inducing activity during in vitro dialysis.
Kidney international 1988;33(1):29-35.
1988: Dinarello C A; Cannon J G; Wolff S M
New concepts on the pathogenesis of fever.
Reviews of infectious diseases 1988;10(1):168-89.
1988: Dinarello C A
Interleukin-1--its multiple biological effects and its association with hemodialysis.
Blood purification 1988;6(3):164-72.
1988: Shaldon S; Dinarello C; Elie M; Koch K M
Interleukin-1 and biocompatibility in haemodialysis.
Contributions to nephrology 1988;62():128-31.
1988: Bingel M; Lonnemann G; Koch K M; Dinarello C A; Shaldon S
Plasma interleukin-1 activity during hemodialysis: the influence of dialysis membranes.
Nephron 1988;50(4):273-6.
1988: Lonnemann G; Endres S; van der Meer J W; Cannon J G; Dinarello C A
A radioimmunoassay for human interleukin-1 alpha: measurement of IL-1 alpha produced in vitro by human blood mononuclear cells stimulated with endotoxin.
Lymphokine research 1988;7(2):75-84.
1988: Shaldon S; Koch K M; Dinarello C A
Interleukin-1 activation and acute phase response during hemodialysis.
Contributions to nephrology 1988;61():18-26.
1988: Shaldon S; Dinarello C A; Koch K M; Lonnemann G; Bingel M; Granolleras C; Deschodt G; Branger B; Oulès R; Fourcade J
Interleukin-1 and dialysis.
Advances in nephrology from the Necker Hospital 1988;17():423-34.
1988: Dinarello C A
Interleukin-1.
Annals of the New York Academy of Sciences 1988;546():122-32.
1987: Dinarello C A
The biology of interleukin 1 and comparison to tumor necrosis factor.
Immunology letters 1987;16(3-4):227-31.
1987: Bishai I; Dinarello C A; Coceani F
Prostaglandin formation in feline cerebral microvessels: effect of endotoxin and interleukin-1.
Canadian journal of physiology and pharmacology 1987;65(11):2225-30.
1987: Shaldon S; Dinarello C A
The relationship between biocompatibility and interleukin-1.
Life support systems : the journal of the European Society for Artificial Organs 1987;5(4):341-5.
1987: Shaldon S; Elie M; Koch K M; Dinarello C A
Interleukin-1 stimulation in the ESRD patient: potential long-term consequences.
Transplantation proceedings 1987;19(5):4353-7.
1987: Okusawa S; Dinarello C A; Yancey K B; Endres S; Lawley T J; Frank M M; Burke J F; Gelfand J A
C5a induction of human interleukin 1. Synergistic effect with endotoxin or interferon-gamma.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(8):2635-40.
1987: Dinarello C A; Ikejima T; Warner S J; Orencole S F; Lonnemann G; Cannon J G; Libby P
Interleukin 1 induces interleukin 1. I. Induction of circulating interleukin 1 in rabbits in vivo and in human mononuclear cells in vitro.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(6):1902-10.
1987: Auron P E; Warner S J; Webb A C; Cannon J G; Bernheim H A; McAdam K J; Rosenwasser L J; LoPreste G; Mucci S F; Dinarello C A
Studies on the molecular nature of human interleukin 1.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(5):1447-56.
1987: Bingel M; Lonnemann G; Koch K M; Dinarello C A; Shaldon S
Enhancement of in-vitro human interleukin-1 production by sodium acetate.
Lancet 1987;1(8523):14-6.
1987: Lonnemann G; Bingel M; Koch K M; Shaldon S; Dinarello C A
Plasma interleukin-1 activity in humans undergoing hemodialysis with regenerated cellulosic membranes.
Lymphokine research 1987;6(2):63-70.
1987: Shaldon S; Dinarello C A; Wyler D J
Induction of interleukin-1 during CAPD.
Contributions to nephrology 1987;57():207-12.
1987: Dinarello C A; Lonnemann G; Bingel M; Koch K M; Shaldon S
Biological consequences of monocyte activation during hemodialysis.
Contributions to nephrology 1987;59():1-9.
1987: Dinarello C A
Interleukin-1: multiple biological properties and mechanisms of action.
Advances in prostaglandin, thromboxane, and leukotriene research 1987;17B():900-4.
1986: Pincus S H; Whitcomb E A; Dinarello C A
Interaction of IL 1 and TPA in modulation of eosinophil function.
Journal of immunology (Baltimore, Md. : 1950) 1986;137(11):3509-14.
1986: Dinarello C A; Dempsey R A; Allegretta M; LoPreste G; Dainiak N; Parkinson D R; Mier J W
Inhibitory effects of elevated temperature on human cytokine production and natural killer activity.
Cancer research 1986;46(12 Pt 1):6236-41.
1986: Dinarello C A; Cannon J G; Mier J W; Bernheim H A; LoPreste G; Lynn D L; Love R N; Webb A C; Auron P E; Reuben R C
Multiple biological activities of human recombinant interleukin 1.
The Journal of clinical investigation 1986;77(6):1734-9.
1986: Bingel M; Lonnemann G; Shaldon S; Koch K M; Dinarello C A
Human interleukin-1 production during hemodialysis.
Nephron 1986;43(3):161-3.
1985: Mier J W; Souza L M; Allegretta M; Boone T; Bernheim H A; Dinarello C A
Dissimilarities between purified human interleukin-1 and recombinant human interleukin-2 in the induction of fever, brain prostaglandin, and acute-phase protein synthesis.
Journal of biological response modifiers 1985;4(1):35-45.
1982: Dempsey R A; Dinarello C A; Mier J W; Rosenwasser L J; Allegretta M; Brown T E; Parkinson D R
The differential effects of human leukocyte pyrogen/lymphocyte-activating factor, T cell growth factor, and interferon on human natural killer activity.
Journal of immunology (Baltimore, Md. : 1950) 1982;129(6):2504-10.

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