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Charles Dinarello

Research Profile

Chemicals & Drugs

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Inflammation

Anatomy

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Christopher Lupfer; Jennifer Martinez; Sandra Milasta; Paul Thomas; Peter Vogel; Ramnik J Xavier; Mondira Kundu; Mohamed Lamkanfi; Paras K Anand; Hongbo Chi; Charles A Dinarello; Peter C Doherty; Douglas R Green; Maggie Green; Gonghua Huang; Thirumala-Devi Kanneganti
Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection.
Yaron Carmi; Charles A Dinarello; Shahar Dotan; Monica Huszar; Irena Kaplanov; Peleg Rider; Shai Abutbul; Ron N Apte; Rona Baron; Malka R White; Elena Voronov
The role of IL-1β in the early tumor cell-induced angiogenic response.
Cecilia B Levandowski; Christina M Mailloux; Kimberly K McFann; Songtao Ben; Charles A Dinarello; Pamela R Fain; Tracey M Ferrara; Katherine Gowan; Paulene J Holland; Ying Jin; Richard A Spritz
NLRP1 haplotypes associated with vitiligo and autoimmunity increase interleukin-1β processing via the NLRP1 inflammasome.

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All Publications

2013: Christopher Lupfer; Jennifer Martinez; Sandra Milasta; Paul Thomas; Peter Vogel; Ramnik J Xavier; Mondira Kundu; Mohamed Lamkanfi; Paras K Anand; Hongbo Chi; Charles A Dinarello; Peter C Doherty; Douglas R Green; Maggie Green; Gonghua Huang; Thirumala-Devi Kanneganti
Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection.
Nature immunology 2013;14(5):480-8.
2013: Yaron Carmi; Charles A Dinarello; Shahar Dotan; Monica Huszar; Irena Kaplanov; Peleg Rider; Shai Abutbul; Ron N Apte; Rona Baron; Malka R White; Elena Voronov
The role of IL-1β in the early tumor cell-induced angiogenic response.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(7):3500-9.
2013: Cecilia B Levandowski; Christina M Mailloux; Kimberly K McFann; Songtao Ben; Charles A Dinarello; Pamela R Fain; Tracey M Ferrara; Katherine Gowan; Paulene J Holland; Ying Jin; Richard A Spritz
NLRP1 haplotypes associated with vitiligo and autoimmunity increase interleukin-1β processing via the NLRP1 inflammasome.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(8):2952-6.
2013: Mark S Gresnigt; Cor W M Jacobs; Leo A B Joosten; Mihai G Netea; Berenice Rösler; Katharina L Becker; Charles A Dinarello; Jos W M van der Meer; Frank van de Veerdonk
The IL-36 receptor pathway regulates Aspergillus fumigatus-induced Th1 and Th17 responses.
European journal of immunology 2013;43(2):416-26.
2013: Weimin Liu; Yuchun Luo; David A Norris; Charles A Dinarello; Jeffrey H Dunn; Mayumi Fujita
Dual role of apoptosis-associated speck-like protein containing a CARD (ASC) in tumorigenesis of human melanoma.
The Journal of investigative dermatology 2013;133(2):518-27.
2012: Mark S Gresnigt; Leo A B Joosten; Mihai G Netea; Jos W M van der Meer; Ineke Verschueren; Charles A Dinarello; Frank van de Veerdonk
Neutrophil-mediated inhibition of proinflammatory cytokine responses.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(10):4806-15.
2012: Mattias S Dahllöf; Charles A Dinarello; Lars G Grunnet; Morten Lundh; Dan P Christensen; Paolo Mascagni; Thomas Mandrup-Poulsen
The lysine deacetylase inhibitor Givinostat inhibits β-cell IL-1β induced IL-1β transcription and processing.
Islets 2012;4(6):417-22.
2012: Bas Heinhuis; Mihai G Netea; Wim B van den Berg; Charles A Dinarello; Leo A B Joosten
Interleukin-32: a predominantly intracellular proinflammatory mediator that controls cell activation and cell death.
Cytokine 2012;60(2):321-7.
2012: Charles A Dinarello
Keep up the heat on IL-1.
Blood 2012;120(13):2538-9.
2012: Charles A Dinarello; Anna Simon; Jos W M van der Meer
Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases.
Nature reviews. Drug discovery 2012;11(8):633-52.
2012: Claudia Cavelti-Weder; Charles A Dinarello; Andrea Babians-Brunner; Cornelia Keller; Malaika Kurz-Levin; Thomas Mandrup-Poulsen; Alan M Solinger; Marc A Stahel; Hany Zayed; Marc Y Donath
Effects of gevokizumab on glycemia and inflammatory markers in type 2 diabetes.
Diabetes care 2012;35(8):1654-62.
2012: Charles A Dinarello
Membrane interleukin-18 revisits membrane IL-1α in T-helper type 1 responses.
European journal of immunology 2012;42(6):1385-7.
2012: Ahmet Gül; Amer Mirza; Leonid Reznikov; Patrick Scannon; Charles A Dinarello; Bahar Artim Esen; Ilknur Tugal-Tutkun; Alan Solinger
Interleukin-1β-regulating antibody XOMA 052 (gevokizumab) in the treatment of acute exacerbations of resistant uveitis of Behcet's disease: an open-label pilot study.
Annals of the rheumatic diseases 2012;71(4):563-6.
2012: Frank van de Veerdonk; Jos W M van der Meer; Gouping Wu; Tania Azam; Aaron N Boeckermann; Ruyi Hao; Leo A B Joosten; Vassili Kalabokis; Mihai G Netea; Angela K Stoeckman; Charles A Dinarello
IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(8):3001-5.
2012: Bas Heinhuis; Marije I Koenders; Mihai G Netea; Wim B van den Berg; Charles A Dinarello; Leo A B Joosten
Interleukin 32 (IL-32) contains a typical α-helix bundle structure that resembles focal adhesion targeting region of focal adhesion kinase-1.
The Journal of biological chemistry 2012;287(8):5733-43.
2012: Carl K Edwards; Mayumi Fujita; Julie S Green; Tatsuya Kawaguchi; Brian L Kotzin; Hiroaki Mitsuya; David A Norris; Ken-Mei Sakata; Michael Schiff; David Trollinger; Hans-Dieter Volk; Danute Bankaitis-Davis; Michael P Bevilacqua; John Cheronis; Charles A Dinarello; Gerd-Rudiger Burmester
Combined anti-tumor necrosis factor-α therapy and DMARD therapy in rheumatoid arthritis patients reduces inflammatory gene expression in whole blood compared to DMARD therapy alone.
Frontiers in immunology 2012;3():366.
2012: Laura Chiossone; Marc Dalod; Charles A Dinarello; Catherine Farnarier; Stefan Jordan; Sandra Audonnet; Yael Berda-Haddad; Lionel Chasson; Bruno Chetaille; Ulrich H Koszinowski; Karin Mazodier; Daniela Novick; Eric Vivier; Gilles Kaplanski
Protection from inflammatory organ damage in a murine model of hemophagocytic lymphohistiocytosis using treatment with IL-18 binding protein.
Frontiers in immunology 2012;3():239.
2012: Charles A Dinarello
Grand challenge in inflammation.
Frontiers in immunology 2012;3():12.
2012: Benjamin W Van Tassell; Norbert F Voelkel; Ross Arena; Tania Azam; Justin Canada; Charles A Dinarello; Eleonora Mezzaroma; Ignacio M Seropian; Keyur Shah; Stefano Toldo; Antonio Abbate
Enhanced interleukin-1 activity contributes to exercise intolerance in patients with systolic heart failure.
PloS one 2012;7(3):e33438.
2012: Jieru Wang; David Wentworth; Bin Zhou; Taylor Alford; Charles A Dinarello; Bifeng Gao; Kevan Hartshorn; Yoko Ito; Piruz Nahreini; Mrinalini P Nikrad; Tzulip Phang; Emily A Travanty; Robert J Mason
Innate immune response of human alveolar macrophages during influenza A infection.
PloS one 2012;7(3):e29879.
2011: Anna Rubartelli; Marco Gattorno; Mihai G Netea; Charles A Dinarello
Interplay between redox status and inflammasome activation.
Trends in immunology 2011;32(12):559-66.
2011: Mara G Shainheit; Arlene H Sharpe; Patrick M Smith; Charles A Dinarello; Eduardo Finger; Bridget M Larkin; Krzysztof W Lasocki; Laura I Rutitzky; Miguel J Stadecker
The pathogenic Th17 cell response to major schistosome egg antigen is sequentially dependent on IL-23 and IL-1β.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(10):5328-35.
2011: A Mario Marcondes; George E Sale; Laura Tabellini; Matthias Bartenstein; Charles A Dinarello; John A Hansen; Julia Kabacka; Xiang Li; H Joachim Deeg
Inhibition of IL-32 activation by α-1 antitrypsin suppresses alloreactivity and increases survival in an allogeneic murine marrow transplantation model.
Blood 2011;118(18):5031-9.
2011: Xiyuan Bai; Ling-Yi Chang; Kathryn Chmura; James D Crapo; Charles A Dinarello; Jennifer R Honda; Amanda Kamali; Marinka Kartalija; Rebecca E Oberley-Deegan; Alida R Ovrutsky; Edward D Chan
IL-32 expression in the airway epithelial cells of patients with Mycobacterium avium complex lung disease.
International immunology 2011;23(11):679-91.
2011: Peleg Rider; Elena Voronov; Malka R White; Alex Braiman; Yaron Carmi; Idan Cohen; Charles A Dinarello; Ofer Guttman; Ron N Apte
IL-1α and IL-1β recruit different myeloid cells and promote different stages of sterile inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(9):4835-43.
2011: Yehuda Kamari; Michal Kandel-Kfir; Sarita Olteanu; Aviv Shaish; Shay Shemesh; Einav Vax; Elana Voronov; Ron N Apte; Yaron Arbel; Iris Barshack; Charles A Dinarello; Shahar Dotan; Dror Harats
Lack of interleukin-1α or interleukin-1β inhibits transformation of steatosis to steatohepatitis and liver fibrosis in hypercholesterolemic mice.
Journal of hepatology 2011;55(5):1086-94.
2011: Eóin N McNamee; Marcel Nold; Claudia Nold-Petry; Philip Bufler; Colm Collins; Charles A Dinarello; Almut Grenz; Paul Jedlicka; Joanne C Masterson; Martine McManus; Jesús Rivera-Nieves
Interleukin 37 expression protects mice from colitis.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(40):16711-6.
2011: Diana Boraschi; Philip Bufler; Stefan Hainzl; Paola Italiani; Maria Leitner; Davide Lucchesi; Elisabeth Maier; Doris Mangelberger; Marcel F Nold; Claudia A Nold-Petry; Gertie J Oostingh; Tobias Pfaller; Claudia Pixner; Gernot Posselt; Charles A Dinarello
IL-37: a new anti-inflammatory cytokine of the IL-1 family.
European cytokine network 2011;22(3):127-47.
2011: Stefano Toldo; Benjamin W Van Tassell; Norbert Voelkel; Charles A Dinarello; Eli C Lewis; Eleonora Mezzaroma; Fadi Salloum; Ignacio M Seropian; Antonio Abbate
Alpha-1 antitrypsin inhibits caspase-1 and protects from acute myocardial ischemia-reperfusion injury.
Journal of molecular and cellular cardiology 2011;51(2):244-51.
2011: Alexander R Moschen; Teresa Fritz; Andrew D Clouston; Ilka Rebhan; Oliver Bauhofer; Helen D Barrie; Elizabeth E Powell; Soo-Hyun Kim; Charles A Dinarello; Ralf Bartenschlager; Julie R Jonsson; Herbert Tilg
Interleukin-32: a new proinflammatory cytokine involved in hepatitis C virus-related liver inflammation and fibrosis.
Hepatology (Baltimore, Md.) 2011;53(6):1819-29.
2011: Charles A Dinarello; Gianluca Fossati; Paolo Mascagni
Histone deacetylase inhibitors for treating a spectrum of diseases not related to cancer.
Molecular medicine (Cambridge, Mass.) 2011;17(5-6):333-52.
2011: Mihai G Netea; Charles A Dinarello
More than inflammation: interleukin-1beta polymorphisms and the lipid metabolism.
The Journal of clinical endocrinology and metabolism 2011;96(5):1279-81.
2011: Jelena Vojinovic; Nemanja Damjanov; Carmine D'Urzo; Antonio Furlan; Gordana Susic; Srdjan Pasic; Nicola Iagaru; Mariana Stefan; Charles A Dinarello
Safety and efficacy of an oral histone deacetylase inhibitor in systemic-onset juvenile idiopathic arthritis.
Arthritis and rheumatism 2011;63(5):1452-8.
2011: Charles A Dinarello
A clinical perspective of IL-1β as the gatekeeper of inflammation.
European journal of immunology 2011;41(5):1203-17.
2011: Michael L Dustin; Robert Rothlein; Atul K Bhan; Charles A Dinarello; Timothy A Springer
Induction by IL 1 and interferon-γ: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J. Immunol. 1986. 137: 245-254.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(9):5024-33.
2011: Shay Matalon; Thomas A Rasmussen; Charles A Dinarello
Histone deacetylase inhibitors for purging HIV-1 from the latent reservoir.
Molecular medicine (Cambridge, Mass.) 2011;17(5-6):466-72.
2011: Antonio Furlan; Flavio Leoni; Paolo Mascagni; Daniela Modena; Valmen Monzani; Leonid L Reznikov; Gianluca Fossati; Charles A Dinarello
Pharmacokinetics, safety and inducible cytokine responses during a phase 1 trial of the oral histone deacetylase inhibitor ITF2357 (givinostat).
Molecular medicine (Cambridge, Mass.) 2011;17(5-6):353-62.
2011: Eli C Lewis; Lykke Blaabjerg; Charles A Dinarello; Paolo Mascagni; Sif G Ronn; Joachim Størling; Thomas Mandrup-Poulsen
The oral histone deacetylase inhibitor ITF2357 reduces cytokines and protects islet β cells in vivo and in vitro.
Molecular medicine (Cambridge, Mass.) 2011;17(5-6):369-77.
2011: Charles A Dinarello
Interleukin-1 in the pathogenesis and treatment of inflammatory diseases.
Blood 2011;117(14):3720-32.
2011: Jarod A Zepp; Claudia Nold-Petry; Charles A Dinarello; Marcel Nold
Protection from RNA and DNA viruses by IL-32.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(7):4110-8.
2011: Bas Heinhuis; Marije I Koenders; Piet L van Riel; Fons A J van de Loo; Charles A Dinarello; Mihai G Netea; Wim B van den Berg; Leo A B Joosten
Tumour necrosis factor alpha-driven IL-32 expression in rheumatoid arthritis synovial tissue amplifies an inflammatory cascade.
Annals of the rheumatic diseases 2011;70(4):660-7.
2011: Rob J W Arts; Leo A B Joosten; Charles A Dinarello; Bart Jan Kullberg; Jos W M van der Meer; Mihai G Netea
TREM-1 interaction with the LPS/TLR4 receptor complex.
European cytokine network 2011;22(1):11-4.
2011: Frank van de Veerdonk; Mihai G Netea; Charles A Dinarello; Leo A B Joosten
Inflammasome activation and IL-1β and IL-18 processing during infection.
Trends in immunology 2011;32(3):110-6.
2011: Yehuda Kamari; Aviv Shaish; Shay Shemesh; Einav Vax; Itamar Grosskopf; Shahar Dotan; Malka White; Elena Voronov; Charles A Dinarello; Ron N Apte; Dror Harats
Reduced atherosclerosis and inflammatory cytokines in apolipoprotein-E-deficient mice lacking bone marrow-derived interleukin-1α.
Biochemical and biophysical research communications 2011;405(2):197-203.
2011: Charles A Dinarello
Blocking interleukin-1β in acute and chronic autoinflammatory diseases.
Journal of internal medicine 2011;269(1):16-28.
2010: Jida Choi; Suyoung Bae; Jaewoo Hong; Soyoon Ryoo; Hyunjhung Jhun; Kwangwon Hong; Doyoung Yoon; Siyoung Lee; Erk Her; Wonhyuk Choi; Jeonghwan Kim; Tania Azam; Charles A Dinarello; Soohyun Kim
Paradoxical effects of constitutive human IL-32{gamma} in transgenic mice during experimental colitis.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(49):21082-6.
2010: Paola Migliorini; Consuelo Anzilotti; Federico Pratesi; Paola Quattroni; Marco Bargagna; Charles A Dinarello; Diana Boraschi
Serum and urinary levels of IL-18 and its inhibitor IL-18BP in systemic lupus erythematosus.
European cytokine network 2010;21(4):264-71.
2010: Moshe Elkabets; Vera S G Ribeiro; Charles A Dinarello; Suzanne Ostrand-Rosenberg; James P Di Santo; Ron N Apte; Christian A J Vosshenrich
IL-1β regulates a novel myeloid-derived suppressor cell subset that impairs NK cell development and function.
European journal of immunology 2010;40(12):3347-57.
2010: Leo A B Joosten; Frank van de Veerdonk; Alieke G Vonk; Otto C Boerman; Monique Keuter; Giamila Fantuzzi; Ineke Verschueren; Tom van der Poll; Charles A Dinarello; Bart Jan Kullberg; Jos W M van der Meer; Mihai G Netea
Differential susceptibility to lethal endotoxaemia in mice deficient in IL-1α, IL-1β or IL-1 receptor type I.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2010;118(12):1000-7.
2010: Marcel F Nold; Claudia A Nold-Petry; Jarod A Zepp; Brent E Palmer; Philip Bufler; Charles A Dinarello
IL-37 is a fundamental inhibitor of innate immunity.
Nature immunology 2010;11(11):1014-22.
2010: Charles A Dinarello
How interleukin-1β induces gouty arthritis.
Arthritis and rheumatism 2010;62(11):3140-4.
2010: Bas Heinhuis; Marije I Koenders; Fons A J van de Loo; P L E M van Lent; Soo-Hyun Kim; Charles A Dinarello; Leo A B Joosten; Wim B van den Berg
IL-32gamma and Streptococcus pyogenes cell wall fragments synergise for IL-1-dependent destructive arthritis via upregulation of TLR-2 and NOD2.
Annals of the rheumatic diseases 2010;69(10):1866-72.
2010: Charles A Dinarello; Marc Y Donath; Thomas Mandrup-Poulsen
Role of IL-1beta in type 2 diabetes.
Current opinion in endocrinology, diabetes, and obesity 2010;17(4):314-21.
2010: Bernhard Maier; Takeshi Ogihara; Anthony P Trace; Sarah A Tersey; Reiesha D Robbins; Swarup K Chakrabarti; Craig S Nunemaker; Natalie D Stull; Catherine A Taylor; John E Thompson; Richard S Dondero; Eli C Lewis; Charles A Dinarello; Jerry L Nadler; Raghavendra G Mirmira
The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice.
The Journal of clinical investigation 2010;120(6):2156-70.
2010: Charles A Dinarello
Why not treat human cancer with interleukin-1 blockade?
Cancer metastasis reviews 2010;29(2):317-29.
2010: Antonio Abbate; Michael C Kontos; John D Grizzard; Giuseppe G L Biondi-Zoccai; Benjamin W Van Tassell; Roshanak Robati; Lenore M Roach; Ross Arena; Charlotte S Roberts; Amit Varma; Christopher C Gelwix; Fadi Salloum; Andrea Hastillo; Charles A Dinarello; George W Vetrovec
Interleukin-1 blockade with anakinra to prevent adverse cardiac remodeling after acute myocardial infarction (Virginia Commonwealth University Anakinra Remodeling Trial [VCU-ART] Pilot study).
The American journal of cardiology 2010;105(10):1371-1377.e1.
2010: Shay Matalon; Brent E Palmer; Marcel Nold; Antonio Furlan; Afework Kassu; Gianluca Fossati; Paolo Mascagni; Charles A Dinarello
The histone deacetylase inhibitor ITF2357 decreases surface CXCR4 and CCR5 expression on CD4(+) T-cells and monocytes and is superior to valproic acid for latent HIV-1 expression in vitro.
Journal of acquired immune deficiency syndromes (1999) 2010;54(1):1-9.
2010: Antonio Abbate; Benjamin W Van Tassell; Ignacio M Seropian; Stefano Toldo; Roshanak Robati; Amit Varma; Fadi Salloum; Lisa Smithson; Charles A Dinarello
Interleukin-1beta modulation using a genetically engineered antibody prevents adverse cardiac remodelling following acute myocardial infarction in the mouse.
European journal of heart failure 2010;12(4):319-22.
2010: Xiyuan Bai; Soo-Hyun Kim; Tania Azam; Mischa T McGibney; Hua Huang; Charles A Dinarello; Edward D Chan
IL-32 is a host protective cytokine against Mycobacterium tuberculosis in differentiated THP-1 human macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(7):3830-40.
2010: Charles A Dinarello
Anti-inflammatory Agents: Present and Future.
Cell 2010;140(6):935-50.
2010: Charles A Dinarello
IL-1: discoveries, controversies and future directions.
European journal of immunology 2010;40(3):599-606.
2010: Christopher C Silliman; Marguerite R Kelher; Fabia Gamboni-Robertson; Christine Hamiel; Kelly M England; Charles A Dinarello; Travis H Wyman; Samina Y Khan; Nathan J D McLaughlin; Rachel S Bercovitz; Anirban Banerjee
Tumor necrosis factor-alpha causes release of cytosolic interleukin-18 from human neutrophils.
American journal of physiology. Cell physiology 2010;298(3):C714-24.
2010: Daniela Novick; Daniel Elbirt; Galit Miller; Charles A Dinarello; Menachem Rubinstein; Zev M Sthoeger
High circulating levels of free interleukin-18 in patients with active SLE in the presence of elevated levels of interleukin-18 binding protein.
Journal of autoimmunity 2010;34(2):121-6.
2010: Miyako Okamoto; Weimin Liu; Yuchun Luo; Aki Tanaka; Xiangna Cai; David A Norris; Charles A Dinarello; Mayumi Fujita
Constitutively active inflammasome in human melanoma cells mediating autoinflammation via caspase-1 processing and secretion of interleukin-1beta.
The Journal of biological chemistry 2010;285(9):6477-88.
2010: Frank van de Veerdonk; Sanne P. Smeekens; Leo A B Joosten; Bart Jan Kullberg; Charles A Dinarello; Jos W M van der Meer; Mihai G Netea
Reactive oxygen species-independent activation of the IL-1beta inflammasome in cells from patients with chronic granulomatous disease.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(7):3030-3.
2010: Idan Cohen; Peleg Rider; Yaron Carmi; Alex Braiman; Shahar Dotan; Malka R White; Elena Voronov; Michael U Martin; Charles A Dinarello; Ron N Apte
Differential release of chromatin-bound IL-1alpha discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(6):2574-9.
2010: Jaewoo Hong; Suyoung Bae; Youngsun Kang; Doyoung Yoon; Xiyuan Bai; Edward D Chan; Tania Azam; Charles A Dinarello; Siyoung Lee; Erk Her; Gyujin Rho; Soohyun Kim
Suppressing IL-32 in monocytes impairs the induction of the proinflammatory cytokines TNFalpha and IL-1beta.
Cytokine 2010;49(2):171-6.
2010: Richard C Chou; Charles A Dinarello; Judith A Ferry; Paola Dal Cin
A 36-year-old woman with recurrent high-grade fevers, hypotension, and hypertriglyceridemia.
Arthritis care & research 2010;62(1):128-36.
2009: Leo A B Joosten; Mihai G Netea; Giamila Fantuzzi; Marije I Koenders; Monique M A Helsen; Helmut Sparrer; Christine T Pham; Jos W M van der Meer; Charles A Dinarello; Wim B van den Berg
Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta.
Arthritis and rheumatism 2009;60(12):3651-62.
2009: Na'ama A Shein; Nikolaos Grigoriadis; Alexander Alexandrovich; Constantina Simeonidou; Athanasios Lourbopoulos; Eleni Polyzoidou; Victoria Trembovler; Paolo Mascagni; Charles A Dinarello; Esther Shohami
Histone deacetylase inhibitor ITF2357 is neuroprotective, improves functional recovery, and induces glial apoptosis following experimental traumatic brain injury.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(12):4266-75.
2009: Meijing Wang; Jiangning Tan; Yue Wang; Kirstan K Meldrum; Charles A Dinarello; Daniel R Meldrum
IL-18 binding protein-expressing mesenchymal stem cells improve myocardial protection after ischemia or infarction.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(41):17499-504.
2009: Yaron Carmi; Elena Voronov; Shahar Dotan; Nitza Lahat; Michal Rahat; Mina Fogel; Monica Huszar; Malka R White; Charles A Dinarello; Ron N Apte
The role of macrophage-derived IL-1 in induction and maintenance of angiogenesis.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(7):4705-14.
2009: Claudia Nold-Petry; Marcel Nold; Jason W Nielsen; Alex Bustamante; Jarod A Zepp; Kathleen A Storm; Jae-Woo Hong; Soo-Hyun Kim; Charles A Dinarello
Increased cytokine production in interleukin-18 receptor alpha-deficient cells is associated with dysregulation of suppressors of cytokine signaling.
The Journal of biological chemistry 2009;284(38):25900-11.
2009: Gerhard Lonnemann; F H Bahlmann; J Freise; B Hertel; Charles A Dinarello
Low-flux hemodialysis suppresses interferon-gamma production: the possible role of beta2-microglobulin.
Clinical nephrology 2009;72(3):170-6.
2009: Flavia Favilli; Consuelo Anzilotti; Lucia Martinelli; Paola Quattroni; Salvatore De Martino; Federico Pratesi; Detlef Neumann; Silke Beermann; Daniela Novick; Charles A Dinarello; Diana Boraschi; Paola Migliorini
IL-18 activity in systemic lupus erythematosus.
Annals of the New York Academy of Sciences 2009;1173():301-9.
2009: Ahmad H Bani-Hani; Jeffery A Leslie; Hiroshi Asanuma; Charles A Dinarello; Matthew T Campbell; Daniel R Meldrum; Honji Zhang; Karen Hile; Kirstan K Meldrum
IL-18 neutralization ameliorates obstruction-induced epithelial-mesenchymal transition and renal fibrosis.
Kidney international 2009;76(5):500-11.
2009: Yossef Kliger; Ofer Levy; Anat Oren; Haim Ashkenazy; Zohar Tiran; Amit Novik; Avi Rosenberg; Anat Amir; Assaf Wool; Amir Toporik; Ehud Schreiber; Dani Eshel; Zurit Levine; Yossi Cohen; Claudia Nold-Petry; Charles A Dinarello; Itamar Borukhov
Peptides modulating conformational changes in secreted chaperones: from in silico design to preclinical proof of concept.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(33):13797-801.
2009: Johanneke Kleinnijenhuis; Leo A B Joosten; Frank van de Veerdonk; Nigel Savage; Reinout van Crevel; Bart Jan Kullberg; Andre van der Ven; Tom H M Ottenhoff; Charles A Dinarello; Jos W M van der Meer; Mihai G Netea
Transcriptional and inflammasome-mediated pathways for the induction of IL-1beta production by Mycobacterium tuberculosis.
European journal of immunology 2009;39(7):1914-22.
2009: Charles A Dinarello
Interleukin-1beta and the autoinflammatory diseases.
The New England journal of medicine 2009;360(23):2467-70.
2009: J H M van der Meer; Mihai G Netea; Charles A Dinarello
Modulation of muramyl dipeptide stimulation of cytokine production by blood components.
Clinical and experimental immunology 2009;156(3):428-33.
2009: Yaping Sun; Y Eugene Chin; Elizabeth Weisiger; Chelsea Malter; Isao Tawara; Tomomi Toubai; Erin Gatza; Paolo Mascagni; Charles A Dinarello; Pavan Reddy
Cutting edge: Negative regulation of dendritic cells through acetylation of the nonhistone protein STAT-3.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(10):5899-903.
2009: Jeffrey L Olson; Robert J Courtney; Behnaz Rouhani; Naresh Mandava; Charles A Dinarello
Intravitreal anakinra inhibits choroidal neovascular membrane growth in a rat model.
Ocular immunology and inflammation 2009;17(3):195-200.
2009: Charles A Dinarello
Hyperosmolar sodium chloride, p38 mitogen activated protein and cytokine-mediated inflammation.
Seminars in dialysis 2009;22(3):256-9.
2009: Gregory B Pott; Edward D Chan; Charles A Dinarello; Leland Shapiro
Alpha-1-antitrypsin is an endogenous inhibitor of proinflammatory cytokine production in whole blood.
Journal of leukocyte biology 2009;85(5):886-95.
2009: Shlomo Z Ben-Sasson; Jane Hu-Li; Juan Quiel; Stephane Cauchetaux; Maya Ratner; Ilan Shapira; Charles A Dinarello; William Paul
IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(17):7119-24.
2009: Moshe Elkabets; Yakov Krelin; Shahar Dotan; Adelheid Cerwenka; Angel Porgador; Rachel G Lichtenstein; Malka R White; Margot Zoller; Yoichizo Iwakura; Charles A Dinarello; Elena Voronov; Ron N Apte
Host-derived interleukin-1alpha is important in determining the immunogenicity of 3-methylcholantrene tumor cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(8):4874-81.
2009: Frank van de Veerdonk; Leo A B Joosten; Isabel Devesa; Hector Mora-Montes; Thirumala-Devi Kanneganti; Charles A Dinarello; Jos W M van der Meer; Neil A R Gow; Bart Jan Kullberg; Mihai G Netea
Bypassing pathogen-induced inflammasome activation for the regulation of interleukin-1beta production by the fungal pathogen Candida albicans.
The Journal of infectious diseases 2009;199(7):1087-96.
2009: Ji-Da Choi; Su-Young Bae; Jae-Woo Hong; Tania Azam; Charles A Dinarello; Erk Her; Whan-Soo Choi; Bo-Kyung Kim; Chang-Kwon Lee; Do-Young Yoon; Sun-Jong Kim; Soo-Hyun Kim
Identification of the most active interleukin-32 isoform.
Immunology 2009;126(4):535-42.
2009: Claudia Nold-Petry; Marcel Nold; Jarod A Zepp; Soo-Hyun Kim; Norbert F Voelkel; Charles A Dinarello
IL-32-dependent effects of IL-1beta on endothelial cell functions.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(10):3883-8.
2009: Mihai G Netea; Claudia Nold-Petry; Marcel Nold; Leo A B Joosten; Bastian Opitz; Jonathan H M van der Meer; Frank van de Veerdonk; Gerben Ferwerda; Bas Heinhuis; Isabel Devesa; C Joel Funk; Robert J Mason; Bart Jan Kullberg; Anna Rubartelli; Jos W M van der Meer; Charles A Dinarello
Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages.
Blood 2009;113(10):2324-35.
2009: Charles A Dinarello
Targeting the pathogenic role of interleukin 1{beta} in the progression of smoldering/indolent myeloma to active disease.
Mayo Clinic proceedings. Mayo Clinic 2009;84(2):105-7.
2009: John Arcaroli; John E Hokanson; Edward Abraham; Mark W Geraci; James R Murphy; Russell P Bowler; Charles A Dinarello; Lori Silveira; Jeff Sankoff; Daren Heyland; Paul E Wischmeyer; James D Crapo
Extracellular superoxide dismutase haplotypes are associated with acute lung injury and mortality.
American journal of respiratory and critical care medicine 2009;179(2):105-12.
2009: Charles A Dinarello
Immunological and inflammatory functions of the interleukin-1 family.
Annual review of immunology 2009;27():519-50.
2009: Charles A Dinarello
Inflammation in human disease: anticytokine therapy.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2009;15(1 Suppl):134-6.
2009: Daniela Novick; Daniel Elbirt; Charles A Dinarello; Menachem Rubinstein; Zev M Sthoeger
Interleukin-18 binding protein in the sera of patients with Wegener's granulomatosis.
Journal of clinical immunology 2009;29(1):38-45.
2008: Daniela Bosisio; MARISA VULCANO; Annalisa Del Prete; Marina Sironi; Valentina Salvi; Laura Salogni; Elena Riboldi; Flavio Leoni; Charles A Dinarello; Giampiero Girolomoni; Silvano Sozzani
Blocking TH17-polarizing cytokines by histone deacetylase inhibitors in vitro and in vivo.
Journal of leukocyte biology 2008;84(6):1540-8.
2008: Sunjong Kim; Siyoung Lee; Erk Her; Suyoung Bae; Jida Choi; Jaewoo Hong; Jun Jaekal; Doyoung Yoon; Tania Azam; Charles A Dinarello; Soohyun Kim
Proteinase 3-processed form of the recombinant IL-32 separate domain.
BMB reports 2008;41(11):814-9.
2008: Zhibin He; Lawrence Lu; Christopher Altmann; Thomas S Hoke; Danica Ljubanovic; Alkesh Jani; Charles A Dinarello; Sarah Faubel; Charles L Edelstein
Interleukin-18 binding protein transgenic mice are protected against ischemic acute kidney injury.
American journal of physiology. Renal physiology 2008;295(5):F1414-21.
2008: Fiorella Calabrese; Simonetta Baraldo; Erica Bazzan; Francesca Lunardi; Federico Rea; Piero Maestrelli; Graziella Turato; Kim Lokar-Oliani; Alberto Papi; Renzo Zuin; Paolo Sfriso; Elisabetta Balestro; Charles A Dinarello; Marina Saetta
IL-32, a novel proinflammatory cytokine in chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 2008;178(9):894-901.
2008: Eli C Lewis; Mark Mizrahi; Michel Toledano; Nathaniel Defelice; Joanne L Wright; Andrew Churg; Leland Shapiro; Charles A Dinarello
alpha1-Antitrypsin monotherapy induces immune tolerance during islet allograft transplantation in mice.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(42):16236-41.
2008: Costantino Botsios; Paolo Sfriso; Antonio Furlan; Leonardo Punzi; Charles A Dinarello
Resistant Behçet disease responsive to anakinra.
Annals of internal medicine 2008;149(4):284-6.
2008: Pavan Reddy; Yi Sun; Tomomi Toubai; Raimon Duran-Struuck; Shawn G Clouthier; Elizabeth Weisiger; Yoshinobu Maeda; Isao Tawara; Oleg Krijanovski; Erin Gatza; Chen Liu; Chelsea Malter; Paolo Mascagni; Charles A Dinarello; James L M Ferrara
Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenase-dependent DC functions and regulates experimental graft-versus-host disease in mice.
The Journal of clinical investigation 2008;118(7):2562-73.
2008: Marcel Nold; Claudia Nold-Petry; Gregory B Pott; Jarod A Zepp; Milene T Saavedra; Soo-Hyun Kim; Charles A Dinarello
Endogenous IL-32 controls cytokine and HIV-1 production.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(1):557-65.
2008: Joseph A Sennello; Raja Fayad; Maria Pini; Melissa E Gove; Venkatesh Ponemone; Robert J Cabay; Britta Siegmund; Charles A Dinarello; Giamila Fantuzzi
Interleukin-18, together with interleukin-12, induces severe acute pancreatitis in obese but not in nonobese leptin-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(23):8085-90.
2008: Milene T Saavedra; Abby D Patterson; James West; Scott H Randell; David W H Riches; Ken C Malcolm; Carlyne D Cool; Jerry A Nick; Charles A Dinarello
Abrogation of anti-inflammatory transcription factor LKLF in neutrophil-dominated airways.
American journal of respiratory cell and molecular biology 2008;38(6):679-88.
2008: John Cha; Zhiping Wang; Lihua Ao; Ning Zou; Charles A Dinarello; Anirban Banerjee; David A Fullerton; Xianzhong Meng
Cytokines link Toll-like receptor 4 signaling to cardiac dysfunction after global myocardial ischemia.
The Annals of thoracic surgery 2008;85(5):1678-85.
2008: Rainer Glauben; Arvind Batra; Thomas Stroh; Ulrike Erben; Inka Fedke; Hans-Anton Lehr; Franco Leoni; Paolo Mascagni; Charles A Dinarello; Martin Zeitz; Britta Siegmund
Histone deacetylases: novel targets for prevention of colitis-associated cancer in mice.
Gut 2008;57(5):613-22.
2008: Ki-Hong Kim; Jung-Hyun Shim; Eun-Hee Seo; Min-Chul Cho; Jung-Woo Kang; Soo-Hyun Kim; Dae-Yeul Yu; Eun-Young Song; Hee Gu Lee; Jung-Hoon Sohn; JinMan Kim; Charles A Dinarello; Do-Young Yoon
Interleukin-32 monoclonal antibodies for immunohistochemistry, Western blotting, and ELISA.
Journal of immunological methods 2008;333(1-2):38-50.
2008: Sheetal Sharma; Nicole Kulk; Marcel Nold; Ralph Gräf; Soo-Hyun Kim; Dietrich Reinhardt; Charles A Dinarello; Philip Bufler
The IL-1 family member 7b translocates to the nucleus and down-regulates proinflammatory cytokines.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(8):5477-82.
2008: Mihai G Netea; Eli C Lewis; Tania Azam; Leo A B Joosten; Jun Jaekal; Su-Young Bae; Charles A Dinarello; Soo-Hyun Kim
Interleukin-32 induces the differentiation of monocytes into macrophage-like cells.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(9):3515-20.
2008: Rizwan Manzer; Charles A Dinarello; Glen McConville; Robert J Mason
Ozone exposure of macrophages induces an alveolar epithelial chemokine response through IL-1alpha.
American journal of respiratory cell and molecular biology 2008;38(3):318-23.
2008: A Mario Marcondes; Andrew J Mhyre; Derek L Stirewalt; Soo-Hyun Kim; Charles A Dinarello; H Joachim Deeg
Dysregulation of IL-32 in myelodysplastic syndrome and chronic myelomonocytic leukemia modulates apoptosis and impairs NK function.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(8):2865-70.
2008: Xianzhong Meng; Lihua Ao; Yong Song; Ashok Babu; Xiaoping Yang; Maorong Wang; Michael J Weyant; Charles A Dinarello; Joseph C Cleveland; David A Fullerton
Expression of functional Toll-like receptors 2 and 4 in human aortic valve interstitial cells: potential roles in aortic valve inflammation and stenosis.
American journal of physiology. Cell physiology 2008;294(1):C29-35.
2007: Galia Lavi; Elena Voronov; Charles A Dinarello; Ron N Apte; Smadar Cohen
Sustained delivery of IL-1 Ra from biodegradable microspheres reduces the number of murine B16 melanoma lung metastases.
Journal of controlled release : official journal of the Controlled Release Society 2007;123(2):123-30.
2007: Jun Jaekal; Edward Abraham; Tania Azam; Mihai G Netea; Charles A Dinarello; Jong-Seok Lim; Young Yang; Do-Young Yoon; Soo-Hyun Kim
Individual LPS responsiveness depends on the variation of toll-like receptor (TLR) expression level.
Journal of microbiology and biotechnology 2007;17(11):1862-7.
2007: Charles A Dinarello
Historical insights into cytokines.
European journal of immunology 2007;37 Suppl 1():S34-45.
2007: Yehuda Kamari; Rachel Werman-Venkert; Aviv Shaish; Ariel Werman; Ayelet Harari; AYELET GONEN; Elena Voronov; Itamar Grosskopf; Yehonatan Sharabi; Ehud Grossman; Yoichiro Iwakura; Charles A Dinarello; Ron N Apte; Dror Harats
Differential role and tissue specificity of interleukin-1alpha gene expression in atherogenesis and lipid metabolism.
Atherosclerosis 2007;195(1):31-8.
2007: Charles A Dinarello
Mutations in cryopyrin: bypassing roadblocks in the caspase 1 inflammasome for interleukin-1beta secretion and disease activity.
Arthritis and rheumatism 2007;56(9):2817-22.
2007: Do-Young Yoon; Charles A Dinarello
Differential effects of anti-IL-1R accessory protein antibodies on IL-1alpha or IL-1beta-induced production of PGE(2) and IL-6 from 3T3-L1 cells.
Journal of biochemistry and molecular biology 2007;40(4):562-70.
2007: Sarah Faubel; Eli C Lewis; Leonid L Reznikov; Danica Ljubanovic; Thomas S Hoke; Hilary Somerset; Dong-Jin Oh; Lawrence Lu; Christina L Klein; Charles A Dinarello; Charles L Edelstein
Cisplatin-induced acute renal failure is associated with an increase in the cytokines interleukin (IL)-1beta, IL-18, IL-6, and neutrophil infiltration in the kidney.
The Journal of pharmacology and experimental therapeutics 2007;322(1):8-15.
2007: Lihua Ao; Yong Song; David A Fullerton; Charles A Dinarello; Xianzhong Meng
The interaction between myocardial depressant factors in endotoxemic cardiac dysfunction: role of TNF-alpha in TLR4-mediated ICAM-1 expression.
Cytokine 2007;38(3):124-9.
2007: Gregory B Pott; Carrie A Sailer; Reuven Porat; Robert L Peskind; Amy C Fuchs; Jonathan B Angel; Paul R Skolnik; Mark A Jacobson; Michael F Giordano; LeBeaut Pierre Alexandre; Paul C Grint; Charles A Dinarello; Leland Shapiro
Effect of a four-week course of interleukin-10 on cytokine production in a placebo-controlled study of HIV-1-infected subjects.
European cytokine network 2007;18(2):49-58.
2007: Philip E. auron; Andrew C Webb; Lanny J Rosenwasser; Steven F Mucci; Alexander Rich; Sheldon M Wolff; Charles A Dinarello
Nucleotide sequence of human monocyte interleukin 1 precursor cDNA. Proc. Natl. Acad. Sci. USA 1984. 81: 7907-7911.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(9):5413-7.
2007: Charles A Dinarello
A signal for the caspase-1 inflammasome free of TLR.
Immunity 2007;26(4):383-5.
2007: Charles L Edelstein; Thomas S Hoke; Hilary Somerset; Wen-feng Fang; Christina L Klein; Charles A Dinarello; Sarah Faubel
Proximal tubules from caspase-1-deficient mice are protected against hypoxia-induced membrane injury.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2007;22(4):1052-61.
2007: Vladimir Hurgin; Daniela Novick; Ariel Werman; Charles A Dinarello; Menachem Rubinstein
Antiviral and immunoregulatory activities of IFN-gamma depend on constitutively expressed IL-1alpha.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(12):5044-9.
2007: Carrie A Sailer; Gregory B Pott; Charles A Dinarello; Samantha Ma Whinney; Jeri E Forster; Jacqueline K Larson-Duran; Alan Landay; Lena Al-Harthi; Robert T Schooley; Constance A Benson; Franklyn N Judson; Melanie Thompson; Frank J Palella; Leland Shapiro
Whole-blood interleukin-18 level during early HIV-1 infection is associated with reduced CXCR4 coreceptor expression and interferon- gamma levels.
The Journal of infectious diseases 2007;195(5):734-8.
2007: Yakov Krelin; Elena Voronov; Shahar Dotan; Moshe Elkabets; Eli Reich; Mina Fogel; Monica Huszar; Yoichiro Iwakura; Shraga Segal; Charles A Dinarello; Ron N Apte
Interleukin-1beta-driven inflammation promotes the development and invasiveness of chemical carcinogen-induced tumors.
Cancer research 2007;67(3):1062-71.
2007: Charles A Dinarello
Interleukin-18 and the pathogenesis of inflammatory diseases.
Seminars in nephrology 2007;27(1):98-114.
2006: Diana Boraschi; Charles A Dinarello
IL-18 in autoimmunity: review.
European cytokine network 2006;17(4):224-52.
2006: Mihai G Netea; Tania Azam; Gerben Ferwerda; Stephen E Girardin; Soo-Hyun Kim; Charles A Dinarello
Triggering receptor expressed on myeloid cells-1 (TREM-1) amplifies the signals induced by the NACHT-LRR (NLR) pattern recognition receptors.
Journal of leukocyte biology 2006;80(6):1454-61.
2006: Eli C Lewis; Charles A Dinarello
Responses of IL-18- and IL-18 receptor-deficient pancreatic islets with convergence of positive and negative signals for the IL-18 receptor.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(45):16852-7.
2006: Charles A Dinarello; Soo-Hyun Kim
IL-32, a novel cytokine with a possible role in disease.
Annals of the rheumatic diseases 2006;65 Suppl 3():iii61-4.
2006: Charles A Dinarello
The paradox of pro-inflammatory cytokines in cancer.
Cancer metastasis reviews 2006;25(3):307-13.
2006: Fernando Vidal-Vanaclocha; Lorea Mendoza; Naiara Telleria; Clarisa Salado; María Valcárcel; Natalia Gallot; Teresa Carrascal; Eider Egilegor; Jabier Beaskoetxea; Charles A Dinarello
Clinical and experimental approaches to the pathophysiology of interleukin-18 in cancer progression.
Cancer metastasis reviews 2006;25(3):417-34.
2006: Carl K Edwards; Alison M Bendele; Leonid I Reznikov; Giamila Fantuzzi; Elizabeth S Chlipala; Li Li; Lyle L Moldawer; John D Mountz; Yi-Yang Yvonne Li; Charles A Dinarello
Soluble human p55 and p75 tumor necrosis factor receptors reverse spontaneous arthritis in transgenic mice expressing transmembrane tumor necrosis factor alpha.
Arthritis and rheumatism 2006;54(9):2872-85.
2006: Sonia Carta; Sara Tassi; Claudia Semino; Gianluca Fossati; Paolo Mascagni; Charles A Dinarello; Anna Rubartelli
Histone deacetylase inhibitors prevent exocytosis of interleukin-1beta-containing secretory lysosomes: role of microtubules.
Blood 2006;108(5):1618-26.
2006: Mihai G Netea; Tania Azam; Eli C Lewis; Leo A B Joosten; Maorong Wang; Dennis Langenberg; Xianzhong Meng; Edward D Chan; Do-Young Yoon; Tom H M Ottenhoff; Soo-Hyun Kim; Charles A Dinarello
Mycobacterium tuberculosis induces interleukin-32 production through a caspase- 1/IL-18/interferon-gamma-dependent mechanism.
PLoS medicine 2006;3(8):e277.
2006: Tatyana Dvorkin; Xiaoping Song; Shmuel Argov; Rosalyn M White; Margot Zoller; Shraga Segal; Charles A Dinarello; Elena Voronov; Ron N Apte
Immune phenomena involved in the in vivo regression of fibrosarcoma cells expressing cell-associated IL-1alpha.
Journal of leukocyte biology 2006;80(1):96-106.
2006: Edward Abraham; Jerry A Nick; Tania Azam; Soo Hyun Kim; Jean-Paul Mira; Daiva Svetkauskaite; Qianbin He; Martin R Zamora; James Murphy; Jong Sung Park; Katherine Overdier; Charles A Dinarello
Peripheral blood neutrophil activation patterns are associated with pulmonary inflammatory responses to lipopolysaccharide in humans.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(12):7753-60.
2006: Mihai G Netea; Leo A B Joosten; Eli Lewis; Dalan R Jensen; Peter J Voshol; Bart Jan Kullberg; Cees J Tack; Han van Krieken; Soo-Hyun Kim; Anton F H Stalenhoef; Fons A J van de Loo; Ineke Verschueren; Leslie Pulawa; Shizuo Akira; Robert H Eckel; Charles A Dinarello; Wim B van den Berg; Jos W M van der Meer
Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance.
Nature medicine 2006;12(6):650-6.
2006: Rainer Glauben; Arvind Batra; Inka Fedke; Martin Zeitz; Hans-Anton Lehr; Franco Leoni; Paolo Mascagni; Giamila Fantuzzi; Charles A Dinarello; Britta Siegmund
Histone hyperacetylation is associated with amelioration of experimental colitis in mice.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(8):5015-22.
2006: Alison M Morris; Joseph A Sennello; Raja Fayad; Robert H Eckel; Charles A Dinarello; Giamila Fantuzzi
T cell-mediated hepatic inflammation modulates adiponectin levels in mice: role of tumor necrosis factor alpha.
Metabolism: clinical and experimental 2006;55(4):555-9.
2006: Leo A B Joosten; Mihai G Netea; Soo-Hyun Kim; Do-Young Yoon; Birgitte Oppers-Walgreen; Timothy Radstake; Pilar Barrera; Fons A J van de Loo; Charles A Dinarello; Wim B van den Berg
IL-32, a proinflammatory cytokine in rheumatoid arthritis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(9):3298-303.
2006: Daniela Novick; Menachem Rubinstein; Tania Azam; Aharon Rabinkov; Charles A Dinarello; Soo-Hyun Kim
Proteinase 3 is an IL-32 binding protein.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(9):3316-21.
2006: Charles A Dinarello
Interleukin 1 and interleukin 18 as mediators of inflammation and the aging process.
The American journal of clinical nutrition 2006;83(2):447S-455S.
2006: Joshua Portnoy; Tianli Pan; Charles A Dinarello; John M Shannon; Jay Y Westcott; Lening Zhang; Robert J Mason
Alveolar type II cells inhibit fibroblast proliferation: role of IL-1alpha.
American journal of physiology. Lung cellular and molecular physiology 2006;290(2):L307-16.
2006: Robert M Rodriguez; Rabiatu Abdullah; Robert Miller; Linda Barry; Kathrin Lungstras-Bufler; Phillip Bufler; Charles A Dinarello; Edward Abraham
A pilot study of cytokine levels and white blood cell counts in the diagnosis of necrotizing fasciitis.
The American journal of emergency medicine 2006;24(1):58-61.
2006: Charles A Dinarello
Inhibitors of histone deacetylases as anti-inflammatory drugs.
Ernst Schering Research Foundation workshop 2006;(56):45-60.
2005: Xiaoping Song; Yakov Krelin; Tatyana Dvorkin; Olle Bjorkdahl; Shraga Segal; Charles A Dinarello; Elena Voronov; Ron N Apte
CD11b+/Gr-1+ immature myeloid cells mediate suppression of T cells in mice bearing tumors of IL-1beta-secreting cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(12):8200-8.
2005: Charles A Dinarello
Interleukin-1beta.
Critical care medicine 2005;33(12 Suppl):S460-2.
2005: Kyung-Ae Lee; Kyung-Joo Cho; Soo-Hyun Kim; Jung-Hyun Shim; Jong-Seok Lim; Dae-Ho Cho; Min-Sung Song; Charles A Dinarello; Do-Young Yoon
IL-18 E42A mutant is resistant to the inhibitory effects of HPV-16 E6 and E7 oncogenes on the IL-18-mediated immune response.
Cancer letters 2005;229(2):261-70.
2005: Karin Mazodier; Valérie Marin; Daniela Novick; Catherine Farnarier; Stéphane Robitail; Nicolas Schleinitz; Véronique Veit; Pascale Paul; Menachem Rubinstein; Charles A Dinarello; Jean-Robert Harlé; Gilles Kaplanski
Severe imbalance of IL-18/IL-18BP in patients with secondary hemophagocytic syndrome.
Blood 2005;106(10):3483-9.
2005: Mihai G Netea; Tania Azam; Gerben Ferwerda; Stephen E Girardin; Mark Walsh; Jong-Sung Park; Edward Abraham; Jin-Man Kim; Do-Young Yoon; Charles A Dinarello; Soo-Hyun Kim
IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(45):16309-14.
2005: Charles A Dinarello; Gilles Kaplanski
Interleukin-18 treatment options for inflammatory diseases.
Expert review of clinical immunology 2005;1(4):619-32.
2005: Charles A Dinarello
An IL-1 family member requires caspase-1 processing and signals through the ST2 receptor.
Immunity 2005;23(5):461-2.
2005: Jason H Clarke; John Y Cha; Mark D Walsh; Fabia Gamboni-Robertson; Anirban Banerjee; Leonid L Reznikov; Charles A Dinarello; Alden H Harken; Martin D McCarter
Melanoma inhibits macrophage activation by suppressing toll-like receptor 4 signaling.
Journal of the American College of Surgeons 2005;201(3):418-25.
2005: Eli C Lewis; Leland Shapiro; Owen J Bowers; Charles A Dinarello
Alpha1-antitrypsin monotherapy prolongs islet allograft survival in mice.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(34):12153-8.
2005: Raja Fayad; Joseph A Sennello; Soo-Hyun Kim; Maria Pini; Charles A Dinarello; Giamila Fantuzzi
Induction of thymocyte apoptosis by systemic administration of concanavalin A in mice: role of TNF-alpha, IFN-gamma and glucocorticoids.
European journal of immunology 2005;35(8):2304-12.
2005: Charles A Dinarello
The many worlds of reducing interleukin-1.
Arthritis and rheumatism 2005;52(7):1960-7.
2005: Robert P Numerof; Charles A Dinarello; Khusru Asadullah
Cytokines as potential therapeutic targets for inflammatory skin diseases.
European cytokine network 2005;16(2):101-3.
2005: Avril A Fitzgerald; Sharon LeClercq; Alexander Yan; Joanne E Homik; Charles A Dinarello
Rapid responses to anakinra in patients with refractory adult-onset Still's disease.
Arthritis and rheumatism 2005;52(6):1794-803.
2005: Charles A Dinarello
Blocking IL-1 in systemic inflammation.
The Journal of experimental medicine 2005;201(9):1355-9.
2005: Joseph A Sennello; Raja Fayad; Alison M Morris; Robert H Eckel; Esra Asilmaz; Jason Montez; Jeffrey M Friedman; Charles A Dinarello; Giamila Fantuzzi
Regulation of T cell-mediated hepatic inflammation by adiponectin and leptin.
Endocrinology 2005;146(5):2157-64.
2005: Wei Wang; Sarah Faubel; Danica Ljubanovic; Amit Mitra; Sandor Falk; Jun Kim; Yunxia Tao; Andrei Soloviev; Leonid L Reznikov; Charles A Dinarello; Robert W Schrier; Charles L Edelstein
Endotoxemic acute renal failure is attenuated in caspase-1-deficient mice.
American journal of physiology. Renal physiology 2005;288(5):F997-1004.
2005: Charles A Dinarello
Differences between anti-tumor necrosis factor-alpha monoclonal antibodies and soluble TNF receptors in host defense impairment.
The Journal of rheumatology. Supplement 2005;74():40-7.
2005: Anand Kumar; Sergio Zanotti; Gene Bunnell; Kalim Habet; Ramon Añel; Alex Neumann; Mary Cheang; Charles A Dinarello; David L Cutler; Joseph E Parrillo
Interleukin-10 blunts the human inflammatory response to lipopolysaccharide without affecting the cardiovascular response.
Critical care medicine 2005;33(2):331-40.
2005: Franco Leoni; Gianluca Fossati; Eli C Lewis; Jae-Kwon Lee; Giulia Porro; Paolo Pagani; Daniela Modena; Maria Lusia Moras; Pietro Pozzi; Leonid L Reznikov; Britta Siegmund; Giamila Fantuzzi; Charles A Dinarello; Paolo Mascagni
The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo.
Molecular medicine (Cambridge, Mass.) 2005;11(1-12):1-15.
2005: Rogier J L Stuyt; Mihai G Netea; Ineke Verschueren; Charles A Dinarello; Bart Jan Kullberg; Jos W M van der Meer
Interleukin-18 does not modulate the acute-phase response.
Journal of endotoxin research 2005;11(2):85-8.
2005: Othmar Ludwiczek; Arthur Kaser; Daniela Novick; Charles A Dinarello; Menachem Rubinstein; Herbert Tilg
Elevated systemic levels of free interleukin-18 (IL-18) in patients with Crohn's disease.
European cytokine network 2005;16(1):27-33.
2005: Soo-Hyun Kim; Sun-Young Han; Tania Azam; Do-Young Yoon; Charles A Dinarello
Interleukin-32: a cytokine and inducer of TNFalpha.
Immunity 2005;22(1):131-42.
2004: Hee Gu Lee; Hyoson Kim; Won-Keun Oh; Kyung-Ae Yu; Yong-Kyung Choe; Jong Seog Ahn; Dong-Soo Kim; Soo-Hyun Kim; Charles A Dinarello; Kilhyoun Kim; Do-Young Yoon
Tetramethoxy hydroxyflavone p7F downregulates inflammatory mediators via the inhibition of nuclear factor kappaB.
Annals of the New York Academy of Sciences 2004;1030():555-68.
2004: Sarah Faubel; Danica Ljubanovic; Leonid L Reznikov; Hilary Somerset; Charles A Dinarello; Charles L Edelstein
Caspase-1-deficient mice are protected against cisplatin-induced apoptosis and acute tubular necrosis.
Kidney international 2004;66(6):2202-13.
2004: Othmar Ludwiczek; Edouard Vannier; Ingo Borggraefe; Arthur Kaser; B Siegmund; Charles A Dinarello; Herbert Tilg
Imbalance between interleukin-1 agonists and antagonists: relationship to severity of inflammatory bowel disease.
Clinical and experimental immunology 2004;138(2):323-9.
2004: Britta Siegmund; Joseph A Sennello; Hans-Anton Lehr; Giorgio Senaldi; Charles A Dinarello; Giamila Fantuzzi
Frontline: interferon regulatory factor-1 as a protective gene in intestinal inflammation: role of TCR gamma delta T cells and interleukin-18-binding protein.
European journal of immunology 2004;34(9):2356-64.
2004: Charles A Dinarello
Therapeutic strategies to reduce IL-1 activity in treating local and systemic inflammation.
Current opinion in pharmacology 2004;4(4):378-85.
2004: Mihai G Netea; Bart Jan Kullberg; Liesbeth E H Jacobs; Trees J G Verver-Jansen; Johanna van der Ven-Jongekrijg; Jochem M D Galama; Anton F H Stalenhoef; Charles A Dinarello; Jos W M van der Meer
Chlamydia pneumoniae stimulates IFN-gamma synthesis through MyD88-dependent, TLR2- and TLR4-independent induction of IL-18 release.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(2):1477-82.
2004: Philip Bufler; Fabia Gamboni-Robertson; Tania Azam; Soo-Hyun Kim; Charles A Dinarello
Interleukin-1 homologues IL-1F7b and IL-18 contain functional mRNA instability elements within the coding region responsive to lipopolysaccharide.
The Biochemical journal 2004;381(Pt 2):503-10.
2004: Jae-Kwon Lee; Soo-Hyun Kim; Eli C Lewis; Tania Azam; Leonid L Reznikov; Charles A Dinarello
Differences in signaling pathways by IL-1beta and IL-18.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(23):8815-20.
2004: Jung-Won Park; Christian Taube; Christina H Swasey; Taku Kodama; Anthony Joetham; Annette Balhorn; Katsuyuki Takeda; Nobuaki Miyahara; Corrie B Allen; Azzeddine Dakhama; Soo-Hyun Kim; Charles A Dinarello; Erwin W Gelfand
Interleukin-1 receptor antagonist attenuates airway hyperresponsiveness following exposure to ozone.
American journal of respiratory cell and molecular biology 2004;30(6):830-6.
2004: Christian Taube; Jerry A Nick; Britta Siegmund; Catherine Duez; Katsuyuki Takeda; Yeong Ho Rha; Jung-Won Park; Anthony Joetham; Katie R Poch; Azzeddine Dakhama; Charles A Dinarello; Erwin W Gelfand
Inhibition of early airway neutrophilia does not affect development of airway hyperresponsiveness.
American journal of respiratory cell and molecular biology 2004;30(6):837-43.
2004: Leonid L Reznikov; Javier C Waksman; Tania Azam; Soo-Hyun Kim; Philip Bufler; T Niwa; A Werman; X Zhang; M Pischetsrieder; stanley shaldon; Charles A Dinarello
Effect of advanced glycation end products on endotoxin-induced TNF-alpha, IL-1beta and IL-8 in human peripheral blood mononuclear cells.
Clinical nephrology 2004;61(5):324-36.
2004: Charles A Dinarello
Interleukin-18 and the treatment of rheumatoid arthritis.
Rheumatic diseases clinics of North America 2004;30(2):417-34, ix.
2004: Kathrin Lungstras-Bufler; Philip Bufler; Rabiatu Abdullah; Christine Rutherford; Stefan Endres; Edward Abraham; Charles A Dinarello; Robert M Rodriguez
High cytokine levels at admission are associated with fatal outcome in patients with necrotizing fasciitis.
European cytokine network 2004;15(2):135-8.
2004: Arndt Schottelius; Lyle L Moldawer; Charles A Dinarello; Khusru Asadullah; Wolfram Sterry; Carl K Edwards
Biology of tumor necrosis factor-alpha- implications for psoriasis.
Experimental dermatology 2004;13(4):193-222.
2004: Pavan Reddy; Yoshinobu Maeda; Kevin B Hotary; Chen Liu; Leonid L Reznikov; Charles A Dinarello; James L M Ferrara
Histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces acute graft-versus-host disease and preserves graft-versus-leukemia effect.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(11):3921-6.
2004: Charles A Dinarello
Unraveling the NALP-3/IL-1beta inflammasome: a big lesson from a small mutation.
Immunity 2004;20(3):243-4.
2004: Ariel Werman; Rachel Werman-Venkert; Rosalyn White; Jae-Kwon Lee; Batsheva Werman; Yakov Krelin; Elena Voronov; Charles A Dinarello; Ron N Apte
The precursor form of IL-1alpha is an intracrine proinflammatory activator of transcription.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(8):2434-9.
2004: Meijing Wang; Rajakumar Sankula; Ben M Tsai; Kirstan K Meldrum; Mark W Turrentine; Keith March; John W Brown; Charles A Dinarello; Daniel R Meldrum
P38 MAPK mediates myocardial proinflammatory cytokine production and endotoxin-induced contractile suppression.
Shock (Augusta, Ga.) 2004;21(2):170-4.
2004: Charles A Dinarello
Infection, fever, and exogenous and endogenous pyrogens: some concepts have changed.
Journal of endotoxin research 2004;10(4):201-22.
2004: Dganit Bar; Ron N Apte; Elena Voronov; Charles A Dinarello; Smadar Cohen
A continuous delivery system of IL-1 receptor antagonist reduces angiogenesis and inhibits tumor development.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(1):161-3.
2003: Tania Azam; Daniela Novick; Philip Bufler; Do-Young Yoon; Menachem Rubinstein; Charles A Dinarello; Soo Hyun Kim
Identification of a critical Ig-like domain in IL-18 receptor alpha and characterization of a functional IL-18 receptor complex.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(12):6574-80.
2003: Xiaoping Song; Elena Voronov; Tatyana Dvorkin; Eyal Fima; Emanuela Cagnano; Daniel Benharroch; Yaakov Shendler; Olle Bjorkdahl; Shraga Segal; Charles A Dinarello; Ron N Apte
Differential effects of IL-1 alpha and IL-1 beta on tumorigenicity patterns and invasiveness.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(12):6448-56.
2003: Paola Bossù; Detlef Neumann; Elda Del Giudice; Antonio Ciaramella; Isabelle Gloaguen; Giamila Fantuzzi; Charles A Dinarello; Emma Di Carlo; Piero Musiani; Pier Luigi Meroni; Gianfranco Caselli; Paolo Ruggiero; Diana Boraschi
IL-18 cDNA vaccination protects mice from spontaneous lupus-like autoimmune disease.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(24):14181-6.
2003: Runa Louise Nolsoe; Flemming Pociot; Daniela Novick; Menachem Rubinstein; Soo-Hyun Kim; Charles A Dinarello; Thomas Mandrup-Poulsen
Mutation scan of a type 1 diabetes candidate gene: the human interleukin-18 binding protein gene.
Annals of the New York Academy of Sciences 2003;1005():332-9.
2003: Gerhard Lonnemann; Daniela Novick; M Rubinstein; Charles A Dinarello
Interleukin-18, interleukin-18 binding protein and impaired production of interferon-gamma in chronic renal failure.
Clinical nephrology 2003;60(5):327-34.
2003: Rogier J L Stuyt; Mihai G Netea; Teunis B H Geijtenbeek; Bart Jan Kullberg; Charles A Dinarello; Jos W M van der Meer
Selective regulation of intercellular adhesion molecule-1 expression by interleukin-18 and interleukin-12 on human monocytes.
Immunology 2003;110(3):329-34.
2003: Giamila Fantuzzi; Nirmal K Banda; Carla Guthridge; Andrea Vondracek; Soo-Hyun Kim; Britta Siegmund; Tania Azam; Joseph A Sennello; Charles A Dinarello; William P Arend
Generation and characterization of mice transgenic for human IL-18-binding protein isoform a.
Journal of leukocyte biology 2003;74(5):889-96.
2003: Ronenn Roubenoff; Helen Parise; Hélène A Payette; Leslie W Abad; Ralph D'Agostino; Paul F Jacques; Peter W F Wilson; Charles A Dinarello; Tamara B Harris
Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study.
The American journal of medicine 2003;115(6):429-35.
2003: Anita W Rijneveld; Sandrine Florquin; Peter Speelman; Carl K Edwards; Charles A Dinarello; Tom van der Poll
Interleukin-1 receptor antagonist transiently impairs antibacterial defense but not survival in murine pneumococcal pneumonia.
European cytokine network 2003;14(4):242-5.
2003: Robert J Feezor; Caroline Oberholzer; Henry Baker; Daniela Novick; Menachem Rubinstein; Lyle L Moldawer; John P Pribble; Sonia Souza; Charles A Dinarello; Wolfgang Ertel; Andreas Oberholzer
Molecular characterization of the acute inflammatory response to infections with gram-negative versus gram-positive bacteria.
Infection and immunity 2003;71(10):5803-13.
2003: Craig H Selzman; Mihai G Netea; Michael A Zimmerman; Adriana Weinberg; Leonid L Reznikov; Frederick L Grover; Charles A Dinarello
Atherogenic effects of Chlamydia pneumoniae: refuting the innocent bystander hypothesis.
The Journal of thoracic and cardiovascular surgery 2003;126(3):688-93.
2003: Hélène Payette; Ronenn Roubenoff; Paul F Jacques; Charles A Dinarello; Peter W F Wilson; Leslie W Abad; Tamara Harris
Insulin-like growth factor-1 and interleukin 6 predict sarcopenia in very old community-living men and women: the Framingham Heart Study.
Journal of the American Geriatrics Society 2003;51(9):1237-43.
2003: Charles A Dinarello; Giamila Fantuzzi
Interleukin-18 and host defense against infection.
The Journal of infectious diseases 2003;187 Suppl 2():S370-84.
2003: Sebastiano Gangemi; Giorgio Basile; Rosaria Alba Merendino; Paola Lucia Minciullo; Daniela Novick; Menachem Rubinstein; Charles A Dinarello; Claudia Lo Balbo; Claudio Franceschi; Stefania Basili; Etrusca D' Urbano; Giovanni Daví; Vittorio Nicita-Mauro; Mario Romano
Increased circulating Interleukin-18 levels in centenarians with no signs of vascular disease: another paradox of longevity?
Experimental gerontology 2003;38(6):669-72.
2003: Charles A Dinarello
Anti-cytokine therapeutics and infections.
Vaccine 2003;21 Suppl 2():S24-34.
2003: Ramachandran S Vasan; Lisa M Sullivan; Ronenn Roubenoff; Charles A Dinarello; Tamara Harris; Emelia Benjamin; Douglas B Sawyer; Daniel Levy; Peter W F Wilson; Ralph B D'Agostino
Inflammatory markers and risk of heart failure in elderly subjects without prior myocardial infarction: the Framingham Heart Study.
Circulation 2003;107(11):1486-91.
2003: Elena Voronov; Daniel Shouval; Yakov Krelin; Emanuela Cagnano; Daniel Benharroch; Yoichiro Iwakura; Charles A Dinarello; Ron N Apte
IL-1 is required for tumor invasiveness and angiogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2645-50.
2003: Xuchu Que; Soo-Hyun Kim; Mohammed Sajid; Lars Eckmann; Charles A Dinarello; James H McKerrow; Sharon L Reed
A surface amebic cysteine proteinase inactivates interleukin-18.
Infection and immunity 2003;71(3):1274-80.
2003: Nirmal K Banda; Andrea Vondracek; Damian Kraus; Charles A Dinarello; Soo-Hyun Kim; Alison Bendele; Giorgio Senaldi; William P Arend
Mechanisms of inhibition of collagen-induced arthritis by murine IL-18 binding protein.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(4):2100-5.
2003: Rogier J L Stuyt; Soo-Hyun Kim; Leonid L Reznikov; Giamila Fantuzzi; Daniela Novick; Menachem Rubinstein; Bart Jan Kullberg; Jos W M van der Meer; Charles A Dinarello; Mihai G Netea
Regulation of Staphylococcus epidermidis-induced IFN-gamma in whole human blood: the role of endogenous IL-18, IL-12, IL-1, and TNF.
Cytokine 2003;21(2):65-73.
2003: Maria Teresa Carrascal; Lorea Mendoza; María Valcárcel; Clarisa Salado; Eider Egilegor; Naiara Tellería; Fernando Vidal-Vanaclocha; Charles A Dinarello
Interleukin-18 binding protein reduces b16 melanoma hepatic metastasis by neutralizing adhesiveness and growth factors of sinusoidal endothelium.
Cancer research 2003;63(2):491-7.
2003: Charles A Dinarello; Daniela Novick; Menachem Rubinstein; Gerhard Lonnemann
Interleukin 18 and interleukin 18 binding protein: possible role in immunosuppression of chronic renal failure.
Blood purification 2003;21(3):258-70.
2003: Gerhard Lonnemann; Daniela Novick; Menachem Rubinstein; Jutta Passlick-Deetjen; Dietmar Lang; Charles A Dinarello
A switch to high-flux helixone membranes reverses suppressed interferon-gamma production in patients on low-flux dialysis.
Blood purification 2003;21(3):225-31.
2003: Charles A Dinarello
Setting the cytokine trap for autoimmunity.
Nature medicine 2003;9(1):20-2.
2002: Othmar Ludwiczek; Arthur Kaser; Daniela Novick; Charles A Dinarello; Menachem Rubinstein; Wolfgang Vogel; Herbert Tilg
Plasma levels of interleukin-18 and interleukin-18 binding protein are elevated in patients with chronic liver disease.
Journal of clinical immunology 2002;22(6):331-7.
2002: Charles A Dinarello; Edward Abraham
Does blocking cytokines in sepsis work?
American journal of respiratory and critical care medicine 2002;166(9):1156-7.
2002: Philip Bufler; Tania Azam; Fabia Gamboni-Robertson; Leonid L Reznikov; Sanjay Kumar; Charles A Dinarello; Soo-Hyun Kim
A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(21):13723-8.
2002: Charles A Dinarello
The IL-1 family and inflammatory diseases.
Clinical and experimental rheumatology 2002;20(5 Suppl 27):S1-13.
2002: Ido Yatsiv; Maria Cristina Morganti-Kossmann; Daniel Perez; Charles A Dinarello; Daniela Novick; Menachem Rubinstein; Vivianne I Otto; Mario Rancan; Thomas Kossmann; Claudio A Redaelli; Otmar Trentz; Esther Shohami; Philip F Stahel
Elevated intracranial IL-18 in humans and mice after traumatic brain injury and evidence of neuroprotective effects of IL-18-binding protein after experimental closed head injury.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2002;22(8):971-8.
2002: Travis H Wyman; Charles A Dinarello; Anirban Banerjee; Fabia Gamboni-Robertson; Andrew A Hiester; Kelly M England; Marguerite R Kelher; Christopher C Silliman
Physiological levels of interleukin-18 stimulate multiple neutrophil functions through p38 MAP kinase activation.
Journal of leukocyte biology 2002;72(2):401-9.
2002: Christopher D Raeburn; Charles A Dinarello; Michael A Zimmerman; Casey M Calkins; Benjamin J Pomerantz; Robert C McIntyre; Alden H Harken; Xianzhong Meng
Neutralization of IL-18 attenuates lipopolysaccharide-induced myocardial dysfunction.
American journal of physiology. Heart and circulatory physiology 2002;283(2):H650-7.
2002: Amiram Ariel; Daniela Novick; Menachem Rubinstein; Charles A Dinarello; Ofer Lider; Rami Hershkoviz
IL-12 and IL-18 induce MAP kinase-dependent adhesion of T cells to extracellular matrix components.
Journal of leukocyte biology 2002;72(1):192-8.
2002: Rogier J L Stuyt; Mihai G Netea; Ineke Verschueren; Giamila Fantuzzi; Charles A Dinarello; Jos W M van der Meer; Bart Jan Kullberg
Role of interleukin-18 in host defense against disseminated Candida albicans infection.
Infection and immunity 2002;70(6):3284-6.
2002: Leonid L Reznikov; Soo-Hyun Kim; Li Zhou; Philip Bufler; Igor Goncharov; Monica Tsang; Charles A Dinarello
The combination of soluble IL-18Ralpha and IL-18Rbeta chains inhibits IL-18-induced IFN-gamma.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2002;22(5):593-601.
2002: Mihai G Netea; Bart Jan Kullberg; Jochem M D Galama; Anton F H Stalenhoef; Charles A Dinarello; Jos W M van der Meer
Non-LPS components of Chlamydia pneumoniae stimulate cytokine production through Toll-like receptor 2-dependent pathways.
European journal of immunology 2002;32(4):1188-95.
2002: Mihai G Netea; Rogier J L Stuyt; Soo-Hyun Kim; Jos W M van der Meer; Bart Jan Kullberg; Charles A Dinarello
The role of endogenous interleukin (IL)-18, IL-12, IL-1beta, and tumor necrosis factor-alpha in the production of interferon-gamma induced by Candida albicans in human whole-blood cultures.
The Journal of infectious diseases 2002;185(7):963-70.
2002: Anne Corbaz; Tessa ten Hove; Suzanne Herren; Pierre Graber; Boris Schwartsburd; Ilana Belzer; Jillian Harrison; Thomas Plitz; Marie H Kosco-Vilbois; Soo-Hyun Kim; Charles A Dinarello; Daniela Novick; Sander J H van Deventer; Yolande Chvatchko
IL-18-binding protein expression by endothelial cells and macrophages is up-regulated during active Crohn's disease.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(7):3608-16.
2002: Soo-Hyun Kim; Tania Azam; Daniela Novick; Do-Young Yoon; Leonid L Reznikov; Philip Bufler; Menachem Rubinstein; Charles A Dinarello
Identification of amino acid residues critical for biological activity in human interleukin-18.
The Journal of biological chemistry 2002;277(13):10998-1003.
2002: Franco Leoni; Andrea Zaliani; Giorgio Bertolini; Giulia Porro; Paolo Pagani; Pietro Pozzi; Giancarlo Donà; Gianluca Fossati; Silvano Sozzani; Tania Azam; Philip Bufler; Giamila Fantuzzi; Igor Goncharov; Soo-Hyun Kim; Benjamin J Pomerantz; Leonid L Reznikov; Britta Siegmund; Charles A Dinarello; Paolo Mascagni
The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):2995-3000.
2002: Sin-Hyeog Im; Soo-Hyun Kim; Tania Azam; Natarajan Venkatesh; Charles A Dinarello; Sara Fuchs; Miriam C Souroujon
Rat interleukin-18 binding protein: cloning, expression, and characterization.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2002;22(3):321-8.
2002: Catharina W Wieland; Britta Siegmund; Giorgio Senaldi; Michael Vasil; Charles A Dinarello; Giamila Fantuzzi
Pulmonary inflammation induced by Pseudomonas aeruginosa lipopolysaccharide, phospholipase C, and exotoxin A: role of interferon regulatory factor 1.
Infection and immunity 2002;70(3):1352-8.
2002: Silvia Gatti; Jennifer Beck; Giamila Fantuzzi; Tamas Bartfai; Charles A Dinarello
Effect of interleukin-18 on mouse core body temperature.
American journal of physiology. Regulatory, integrative and comparative physiology 2002;282(3):R702-9.
2002: Marcus Schultz; Anita W Rijneveld; Sandrine Florquin; Carl K Edwards; Charles A Dinarello; Tom van der Poll
Role of interleukin-1 in the pulmonary immune response during Pseudomonas aeruginosa pneumonia.
American journal of physiology. Lung cellular and molecular physiology 2002;282(2):L285-90.
2002: Miguel-Angel Perales; Giamila Fantuzzi; Stacie M Goldberg; Mary Jo Turk; Fariborz Mortazavi; Klaus J Busam; Alan N Houghton; Charles A Dinarello; Jedd D Wolchok
GM-CSF DNA induces specific patterns of cytokines and chemokines in the skin: implications for DNA vaccines.
Cytokines, cellular & molecular therapy 2002;7(3):125-33.
2002: Casey M Calkins; Denis D Bensard; Brian D Shames; Edward J Pulido; Edward Abraham; Nathan Fernandez; Xianzhong Meng; Charles A Dinarello; Robert C McIntyre
IL-1 regulates in vivo C-X-C chemokine induction and neutrophil sequestration following endotoxemia.
Journal of endotoxin research 2002;8(1):59-67.
2001: Christine Plater-Zyberk; Leo A B Joosten; Monique M A Helsen; P Sattonnet-Roche; C Siegfried; Sami Alouani; Fons A J van de Loo; Pierre Graber; S Aloni; Rocco Cirillo; Erik Lubberts; Charles A Dinarello; Wim B van den Berg; Yolande Chvatchko
Therapeutic effect of neutralizing endogenous IL-18 activity in the collagen-induced model of arthritis.
The Journal of clinical investigation 2001;108(12):1825-32.
2001: Britta Siegmund; Hans-Anton Lehr; Giamila Fantuzzi; Charles A Dinarello
IL-1 beta -converting enzyme (caspase-1) in intestinal inflammation.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(23):13249-54.
2001: Charles A Dinarello
Novel targets for interleukin 18 binding protein.
Annals of the rheumatic diseases 2001;60 Suppl 3():iii18-24.
2001: Britta Siegmund; Giamila Fantuzzi; Florian Rieder; Fabia Gamboni-Robertson; Hans-Anton Lehr; Gunther Hartmann; Charles A Dinarello; Stefan Endres; Andreas Eigler
Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production.
American journal of physiology. Regulatory, integrative and comparative physiology 2001;281(4):R1264-73.
2001: H J Choi; Charles A Dinarello; Leland Shapiro
Interleukin-18 inhibits human immunodeficiency virus type 1 production in peripheral blood mononuclear cells.
The Journal of infectious diseases 2001;184(5):560-8.
2001: Valérie Marin; Catherine Farnarier; Sandra Grès; S Kaplanski; M S Su; Charles A Dinarello; Gilles Kaplanski
The p38 mitogen-activated protein kinase pathway plays a critical role in thrombin-induced endothelial chemokine production and leukocyte recruitment.
Blood 2001;98(3):667-73.
2001: Rogier J L Stuyt; Mihai G Netea; Soo-Hyun Kim; Daniela Novick; Menachem Rubinstein; Bart Jan Kullberg; Jos W M van der Meer; Charles A Dinarello
Differential roles of interleukin-18 (IL-18) and IL12 for induction of gamma interferon by staphylococcal cell wall components and superantigens.
Infection and immunity 2001;69(8):5025-30.
2001: Daniela Novick; Boris Schwartsburd; R Pinkus; D Suissa; Ilana Belzer; Z Sthoeger; W F Keane; Yolande Chvatchko; Soo-Hyun Kim; Giamila Fantuzzi; Charles A Dinarello; Menachem Rubinstein
A novel IL-18BP ELISA shows elevated serum IL-18BP in sepsis and extensive decrease of free IL-18.
Cytokine 2001;14(6):334-42.
2001: M Knotek; Boris Rogachev; Wei Wang; Tevfik Ecder; Vyacheslav Y Melnikov; Patricia E Gengaro; Matthew L Esson; Charles L Edelstein; Charles A Dinarello; Robert W Schrier
Endotoxemic renal failure in mice: Role of tumor necrosis factor independent of inducible nitric oxide synthase.
Kidney international 2001;59(6):2243-9.
2001: Vyacheslav Y Melnikov; Tevfik Ecder; Giamila Fantuzzi; Britta Siegmund; M Scott Lucia; Charles A Dinarello; Robert W Schrier; Charles L Edelstein
Impaired IL-18 processing protects caspase-1-deficient mice from ischemic acute renal failure.
The Journal of clinical investigation 2001;107(9):1145-52.
2001: Soo-Hyun Kim; Tania Azam; Do-Young Yoon; Leonid L Reznikov; Daniela Novick; Menachem Rubinstein; Charles A Dinarello
Site-specific mutations in the mature form of human IL-18 with enhanced biological activity and decreased neutralization by IL-18 binding protein.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3304-9.
2001: Benjamin J Pomerantz; Leonid L Reznikov; Alden H Harken; Charles A Dinarello
Inhibition of caspase 1 reduces human myocardial ischemic dysfunction via inhibition of IL-18 and IL-1beta.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2871-6.
2001: A Vázquez-Torres; Giamila Fantuzzi; C K Edwards; Charles A Dinarello; Ferric C Fang
Defective localization of the NADPH phagocyte oxidase to Salmonella-containing phagosomes in tumor necrosis factor p55 receptor-deficient macrophages.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2561-5.
2001: Giamila Fantuzzi; D Reed; M Qi; Sheila Scully; Charles A Dinarello; Giorgio Senaldi
Role of interferon regulatory factor-1 in the regulation of IL-18 production and activity.
European journal of immunology 2001;31(2):369-75.
2001: Charles A Dinarello; Benjamin J Pomerantz
Proinflammatory cytokines in heart disease.
Blood purification 2001;19(3):314-21.
2001: Soo-Hyun Kim; Leonid L Reznikov; Rogier J L Stuyt; Craig H Selzman; Giamila Fantuzzi; T Hoshino; H A Young; Charles A Dinarello
Functional reconstitution and regulation of IL-18 activity by the IL-18R beta chain.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(1):148-54.
2000: Leo A B Joosten; Fons A J van de Loo; Erik Lubberts; Monique M A Helsen; Mihai G Netea; Jos W M van der Meer; Charles A Dinarello; Wim B van den Berg
An IFN-gamma-independent proinflammatory role of IL-18 in murine streptococcal cell wall arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(11):6553-8.
2000: J I Frishman; C K Edwards; M G Sonnenberg; T Kohno; A M Cohen; Charles A Dinarello
Tumor necrosis factor (TNF)-alpha-induced interleukin-8 in human blood cultures discriminates neutralization by the p55 and p75 TNF soluble receptors.
The Journal of infectious diseases 2000;182(6):1722-30.
2000: Charles A Dinarello
Targeting interleukin 18 with interleukin 18 binding protein.
Annals of the rheumatic diseases 2000;59 Suppl 1():i17-20.
2000: Charles A Dinarello
The role of the interleukin-1-receptor antagonist in blocking inflammation mediated by interleukin-1.
The New England journal of medicine 2000;343(10):732-4.
2000: Charles A Dinarello
Interleukin-18, a proinflammatory cytokine.
European cytokine network 2000;11(3):483-6.
2000: Mihai G Netea; AJ Puren; Charles A Dinarello
A short course of oral aspirin increases IL-18-induced interferon-gamma production in whole blood cultures.
European cytokine network 2000;11(3):379-82.
2000: Charles A Dinarello
Proinflammatory cytokines.
Chest 2000;118(2):503-8.
2000: T P Hong; NA Andersen; K Nielsen; Allan E Karlsen; Giamila Fantuzzi; Decio L Eizirik; Charles A Dinarello; Thomas Mandrup-Poulsen
Interleukin-18 mRNA, but not interleukin-18 receptor mRNA, is constitutively expressed in islet beta-cells and up-regulated by interferon-gamma.
European cytokine network 2000;11(2):193-205.
2000: Mihai G Netea; Giamila Fantuzzi; Bart Jan Kullberg; Rogier J L Stuyt; Edward J Pulido; Robert C McIntyre; Leo A B Joosten; Jos W M van der Meer; Charles A Dinarello
Neutralization of IL-18 reduces neutrophil tissue accumulation and protects mice against lethal Escherichia coli and Salmonella typhimurium endotoxemia.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(5):2644-9.
2000: Leonid L Reznikov; Soo-Hyun Kim; J Y Westcott; J Frishman; Giamila Fantuzzi; Daniela Novick; Menachem Rubinstein; Charles A Dinarello
IL-18 binding protein increases spontaneous and IL-1-induced prostaglandin production via inhibition of IFN-gamma.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(5):2174-9.
2000: Soo-Hyun Kim; M Eisenstein; Leonid L Reznikov; Giamila Fantuzzi; Daniela Novick; Menachem Rubinstein; Charles A Dinarello
Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(3):1190-5.
2000: Fernando Vidal-Vanaclocha; Giamila Fantuzzi; Lorea Mendoza; AM Fuentes; MJ Anasagasti; J Martín; Teresa Carrascal; P Walsh; Leonid L Reznikov; S H Kim; Daniela Novick; M Rubinstein; Charles A Dinarello
IL-18 regulates IL-1beta-dependent hepatic melanoma metastasis via vascular cell adhesion molecule-1.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(2):734-9.
2000: Edward Abraham; M A Matthay; Charles A Dinarello; Jean-Louis Vincent; J Cohen; Steven M Opal; M Glauser; P Parsons; Charles J Fisher; John Repine
Consensus conference definitions for sepsis, septic shock, acute lung injury, and acute respiratory distress syndrome: time for a reevaluation.
Critical care medicine 2000;28(1):232-5.
2000: Leonid L Reznikov; Brian D Shames; HA Barton; Craig H Selzman; Giamila Fantuzzi; S H Kim; S M Johnson; Charles A Dinarello
Interleukin-1beta deficiency results in reduced NF-kappaB levels in pregnant mice.
American journal of physiology. Regulatory, integrative and comparative physiology 2000;278(1):R263-70.
1999: Brett C Sheridan; Charles A Dinarello; Daniel R Meldrum; David A Fullerton; Craig H Selzman; Robert C McIntyre
Interleukin-11 attenuates pulmonary inflammation and vasomotor dysfunction in endotoxin-induced lung injury.
The American journal of physiology 1999;277(5 Pt 1):L861-7.
1999: Charles A Dinarello
Interleukin-18.
Methods (San Diego, Calif.) 1999;19(1):121-32.
1999: Giamila Fantuzzi; D A Reed; Charles A Dinarello
IL-12-induced IFN-gamma is dependent on caspase-1 processing of the IL-18 precursor.
The Journal of clinical investigation 1999;104(6):761-7.
1999: BS Cain; Daniel R Meldrum; Charles A Dinarello; Xianzhong Meng; KS Joo; Anirban Banerjee; Alden H Harken
Tumor necrosis factor-alpha and interleukin-1beta synergistically depress human myocardial function.
Critical care medicine 1999;27(7):1309-18.
1999: Leonid L Reznikov; Giamila Fantuzzi; Craig H Selzman; Brian D Shames; HA Barton; H Bell; James A McGregor; Charles A Dinarello
Utilization of endoscopic inoculation in a mouse model of intrauterine infection-induced preterm birth: role of interleukin 1beta.
Biology of reproduction 1999;60(5):1231-8.
1999: E V Granowitz; R Porat; Charles A Dinarello
Circulating leptin during experimental endotoxemia in humans.
The Journal of infectious diseases 1999;179(5):1313-4.
1999: Craig H Selzman; Brian D Shames; Leonid L Reznikov; S A Miller; Xianzhong Meng; HA Barton; A Werman; Alden H Harken; Charles A Dinarello; Anirban Banerjee
Liposomal delivery of purified inhibitory-kappaBalpha inhibits tumor necrosis factor-alpha-induced human vascular smooth muscle proliferation.
Circulation research 1999;84(8):867-75.
1999: Mihai G Netea; Bart Jan Kullberg; Otto Boerman; Ineke Verschueren; Charles A Dinarello; Jos W M van der Meer
Soluble murine IL-1 receptor type I induces release of constitutive IL-1 alpha.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(8):4876-81.
1999: AJ Puren; Giamila Fantuzzi; Charles A Dinarello
Gene expression, synthesis, and secretion of interleukin 18 and interleukin 1beta are differentially regulated in human blood mononuclear cells and mouse spleen cells.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):2256-61.
1999: Edouard Vannier; Arthur Kaser; Michael B Atkins; Giamila Fantuzzi; Charles A Dinarello; J W Mier; Herbert Tilg
Elevated circulating levels of soluble interleukin-1 receptor type II during interleukin-2 immunotherapy.
European cytokine network 1999;10(1):37-42.
1999: Charles A Dinarello
Cytokines as endogenous pyrogens.
The Journal of infectious diseases 1999;179 Suppl 2():S294-304.
1999: Charles A Dinarello; S Gatti; T Bartfai
Fever: links with an ancient receptor.
Current biology : CB 1999;9(4):R147-50.
1999: Giamila Fantuzzi; Charles A Dinarello
Interleukin-18 and interleukin-1 beta: two cytokine substrates for ICE (caspase-1).
Journal of clinical immunology 1999;19(1):1-11.
1999: Daniela Novick; Soo-Hyun Kim; Giamila Fantuzzi; Leonid L Reznikov; Charles A Dinarello; Menachem Rubinstein
Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response.
Immunity 1999;10(1):127-36.
1999: Charles A Dinarello
IL-18: A TH1-inducing, proinflammatory cytokine and new member of the IL-1 family.
The Journal of allergy and clinical immunology 1999;103(1 Pt 1):11-24.
1998: AJ Puren; P Razeghi; Giamila Fantuzzi; Charles A Dinarello
Interleukin-18 enhances lipopolysaccharide-induced interferon-gamma production in human whole blood cultures.
The Journal of infectious diseases 1998;178(6):1830-4.
1998: Daniel R Meldrum; Charles A Dinarello; Brian D Shames; Joseph C Cleveland; BS Cain; Anirban Banerjee; Xianzhong Meng; Alden H Harken
Ischemic preconditioning decreases postischemic myocardial tumor necrosis factor-alpha production. Potential ultimate effector mechanism of preconditioning.
Circulation 1998;98(19 Suppl):II214-8; discussion II218-9.
1998: Leland Shapiro; AJ Puren; H A Barton; Daniela Novick; R L Peskind; Robert Shenkar; Y Gu; M S Su; Charles A Dinarello
Interleukin 18 stimulates HIV type 1 in monocytic cells.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(21):12550-5.
1998: Leonid L Reznikov; AJ Puren; Giamila Fantuzzi; Heiko Muhl; Leland Shapiro; Do-Young Yoon; David L Cutler; Charles A Dinarello
Spontaneous and inducible cytokine responses in healthy humans receiving a single dose of IFN-alpha2b: increased production of interleukin-1 receptor antagonist and suppression of IL-1-induced IL-8.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1998;18(10):897-903.
1998: Charles A Dinarello
Interleukin-1 beta, interleukin-18, and the interleukin-1 beta converting enzyme.
Annals of the New York Academy of Sciences 1998;856():1-11.
1998: Leland Shapiro; Kim A Heidenreich; Mary Kay Meintzer; Charles A Dinarello
Role of p38 mitogen-activated protein kinase in HIV type 1 production in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(13):7422-6.
1998: Menachem Rubinstein; Charles A Dinarello; J J Oppenheim; P Hertzog
Recent advances in cytokines, cytokine receptors and signal transduction.
Cytokine & growth factor reviews 1998;9(2):175-81.
1998: Charles A Dinarello; Daniela Novick; AJ Puren; Giamila Fantuzzi; Leland Shapiro; Heiko Muhl; Do-Young Yoon; Leonid L Reznikov; Soo-Hyun Kim; Menachem Rubinstein
Overview of interleukin-18: more than an interferon-gamma inducing factor.
Journal of leukocyte biology 1998;63(6):658-64.
1998: Do-Young Yoon; Charles A Dinarello
Antibodies to domains II and III of the IL-1 receptor accessory protein inhibit IL-1 beta activity but not binding: regulation of IL-1 responses is via type I receptor, not the accessory protein.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(7):3170-9.
1998: Giamila Fantuzzi; AJ Puren; MW Harding; David J Livingston; Charles A Dinarello
Interleukin-18 regulation of interferon gamma production and cell proliferation as shown in interleukin-1beta-converting enzyme (caspase-1)-deficient mice.
Blood 1998;91(6):2118-25.
1998: Giamila Fantuzzi; Charles A Dinarello
Stem cell factor-deficient mice have a dysregulation of cytokine production during local inflammation.
European cytokine network 1998;9(1):85-92.
1998: AJ Puren; Giamila Fantuzzi; Y Gu; M S Su; Charles A Dinarello
Interleukin-18 (IFNgamma-inducing factor) induces IL-8 and IL-1beta via TNFalpha production from non-CD14+ human blood mononuclear cells.
The Journal of clinical investigation 1998;101(3):711-21.
1998: Charles A Dinarello
Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist.
International reviews of immunology 1998;16(5-6):457-99.
1997: Charles A Dinarello
Interleukin-1.
Cytokine & growth factor reviews 1997;8(4):253-65.
1997: Charles A Dinarello
Proinflammatory and anti-inflammatory cytokines as mediators in the pathogenesis of septic shock.
Chest 1997;112(6 Suppl):321S-329S.
1997: Heiko Muhl; Charles A Dinarello
Macrophage inflammatory protein-1 alpha production in lipopolysaccharide-stimulated human adherent blood mononuclear cells is inhibited by the nitric oxide synthase inhibitor N(G)-monomethyl-L-arginine.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(10):5063-9.
1997: Marcel van Deuren; Johanna van der Ven-Jongekrijg; E Vannier; R van Dalen; Gerard J Pesman; Albert K M Bartelink; Charles A Dinarello; Jos W M van der Meer
The pattern of interleukin-1beta (IL-1beta) and its modulating agents IL-1 receptor antagonist and IL-1 soluble receptor type II in acute meningococcal infections.
Blood 1997;90(3):1101-8.
1997: Giamila Fantuzzi; S Sacco; P Ghezzi; Charles A Dinarello
Physiological and cytokine responses in IL-1 beta-deficient mice after zymosan-induced inflammation.
The American journal of physiology 1997;273(1 Pt 2):R400-6.
1997: Charles A Dinarello; Paul A Bunn
Fever.
Seminars in oncology 1997;24(3):288-98.
1997: Charles A Dinarello
Induction of interleukin-1 and interleukin-1 receptor antagonist.
Seminars in oncology 1997;24(3 Suppl 9):S9-81-S9-93.
1997: Gilles Kaplanski; M Fabrigoule; Vera Boulay; Charles A Dinarello; Pierre Bongrand; S Kaplanski; Catherine Farnarier
Thrombin induces endothelial type II activation in vitro: IL-1 and TNF-alpha-independent IL-8 secretion and E-selectin expression.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(11):5435-41.
1997: Y Le Tulzo; Robert Shenkar; DJ Kaneko; Pierre Moine; Giamila Fantuzzi; Charles A Dinarello; Edward Abraham
Hemorrhage increases cytokine expression in lung mononuclear cells in mice: involvement of catecholamines in nuclear factor-kappaB regulation and cytokine expression.
The Journal of clinical investigation 1997;99(7):1516-24.
1997: L Shapiro; Charles A Dinarello
Hyperosmotic stress as a stimulant for proinflammatory cytokine production.
Experimental cell research 1997;231(2):354-62.
1997: Giamila Fantuzzi; George Ku; MW Harding; David J Livingston; J D Sipe; Keisuke Kuida; RA Flavell; Charles A Dinarello
Response to local inflammation of IL-1 beta-converting enzyme- deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(4):1818-24.
1997: K Aiura; Burton D Clark; Charles A Dinarello; N H Margolis; G Kaplanski; John F Burke; R G Tompkins; Jeffrey A Gelfand
Interaction with autologous platelets multiplies interleukin-1 and tumor necrosis factor production in mononuclear cells.
The Journal of infectious diseases 1997;175(1):123-9.
1996: Brian J G Pereira; Sumuk Sumuk Sundaram; T W Barrett; N K Butt; R Porat; A J King; Charles A Dinarello
Transfer of cytokine-inducing bacterial products across hemodialyzer membranes in the presence of plasma or whole blood.
Clinical nephrology 1996;46(6):394-401.
1996: Burton D Clark; T Ikejima; J Mancilla; S F Orencole; S P Sirko; N Ishii; K Okuda; Charles A Dinarello
An antibody to a 17 amino acid synthetic peptide of the type I interleukin-1 receptor preferentially blocks interleukin-1 beta binding.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1996;16(12):1079-88.
1996: A C Fuchs; E V Granowitz; L Shapiro; E Vannier; Gerhard Lonnemann; J B Angel; J S Kennedy; A R Rabson; E Radwanski; M B Affrime; David L Cutler; P C Grint; Charles A Dinarello
Clinical, hematologic, and immunologic effects of interleukin-10 in humans.
Journal of clinical immunology 1996;16(5):291-303.
1996: Giamila Fantuzzi; H Zheng; Raffaella Faggioni; F Benigni; Pietro Ghezzi; J D Sipe; A R Shaw; Charles A Dinarello
Effect of endotoxin in IL-1 beta-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(1):291-6.
1996: K Ye; E Vannier; Burton D Clark; J E Sims; Charles A Dinarello
Three distinct promoters direct transcription of different 5' untranslated regions of the human interleukin 1 type I receptor: a possible mechanism for control of translation.
Cytokine 1996;8(6):421-9.
1996: Charles A Dinarello
Thermoregulation and the pathogenesis of fever.
Infectious disease clinics of North America 1996;10(2):433-49.
1996: T Takabayashi; E Vannier; Burton D Clark; N H Margolis; Charles A Dinarello; J F Burke; Jeffrey A Gelfand
A new biologic role for C3a and C3a desArg: regulation of TNF-alpha and IL-1 beta synthesis.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(9):3455-60.
1996: E V Granowitz; B M Saget; J B Angel; M Z Wang; A Wang; Charles A Dinarello; P R Skolnik
Soluble tumor necrosis factor receptors inhibit phorbol myristate acetate and cytokine-induced HIV-1 expression chronically infected U1 cells.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1996;11(5):430-7.
1996: Giamila Fantuzzi; Charles A Dinarello
The inflammatory response in interleukin-1 beta-deficient mice: comparison with other cytokine-related knock-out mice.
Journal of leukocyte biology 1996;59(4):489-93.
1996: Charles A Dinarello
Biologic basis for interleukin-1 in disease.
Blood 1996;87(6):2095-147.
1996: F Benigni; Giamila Fantuzzi; S Sacco; Marina Sironi; P Pozzi; Charles A Dinarello; J D Sipe; Valeria Poli; Manuela Cappelletti; G Paonessa; D Pennica; N Panayotatos; Pietro Ghezzi
Six different cytokines that share GP130 as a receptor subunit, induce serum amyloid A and potentiate the induction of interleukin-6 and the activation of the hypothalamus-pituitary-adrenal axis by interleukin-1.
Blood 1996;87(5):1851-4.
1996: S Endres; R E Whitaker; R Ghorbani; S N Meydani; Charles A Dinarello
Oral aspirin and ibuprofen increase cytokine-induced synthesis of IL-1 beta and of tumour necrosis factor-alpha ex vivo.
Immunology 1996;87(2):264-70.
1996: Charles A Dinarello; R A Roubenoff
Mechanisms of loss of lean body mass in patients on chronic dialysis.
Blood purification 1996;14(5):388-94.
1996: Charles A Dinarello
Cytokines as mediators in the pathogenesis of septic shock.
Current topics in microbiology and immunology 1996;216():133-65.
1995: L Shapiro; Charles A Dinarello
Osmotic regulation of cytokine synthesis in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(26):12230-4.
1995: Gilles Kaplanski; N Teysseire; Catherine Farnarier; S Kaplanski; Jean-Claude Lissitzky; Jean Marc Durand; J Soubeyrand; Charles A Dinarello; Pierre Bongrand
IL-6 and IL-8 production from cultured human endothelial cells stimulated by infection with Rickettsia conorii via a cell-associated IL-1 alpha-dependent pathway.
The Journal of clinical investigation 1995;96(6):2839-44.
1995: J B Angel; B M Saget; S P Walsh; T F Greten; Charles A Dinarello; P R Skolnik; Stefan Endres
Rolipram, a specific type IV phosphodiesterase inhibitor, is a potent inhibitor of HIV-1 replication.
AIDS (London, England) 1995;9(10):1137-44.
1995: Debbie Beasley; M E McGuiggin; Charles A Dinarello
Human vascular smooth muscle cells produce an intracellular form of interleukin-1 receptor antagonist.
The American journal of physiology 1995;269(4 Pt 1):C961-8.
1995: Charles A Dinarello
Controlling the production of interleukin-1 and tumor necrosis factor in disease.
Nutrition (Burbank, Los Angeles County, Calif.) 1995;11(5 Suppl):695-7.
1995: Charles A Dinarello
Interleukin-1 and interleukin-1 receptor antagonist.
Nutrition (Burbank, Los Angeles County, Calif.) 1995;11(5 Suppl):492-4.
1995: E V Granowitz; B M Saget; M Z Wang; Charles A Dinarello; P R Skolnik
Interleukin 1 induces HIV-1 expression in chronically infected U1 cells: blockade by interleukin 1 receptor antagonist and tumor necrosis factor binding protein type 1.
Molecular medicine (Cambridge, Mass.) 1995;1(6):667-77.
1995: L C Miller; A Sharma; A F McKusick; J P Tassoni; Charles A Dinarello; M M Kaplan
Synthesis of interleukin-1 beta in primary biliary cirrhosis: relationship to treatment with methotrexate or colchicine and disease progression.
Hepatology (Baltimore, Md.) 1995;22(2):518-24.
1995: M D Mileno; N H Margolis; Burton D Clark; Charles A Dinarello; J F Burke; Jeffrey A Gelfand
Coagulation of whole blood stimulates interleukin-1 beta gene expression.
The Journal of infectious diseases 1995;172(1):308-11.
1995: J B Angel; B M Saget; M Z Wang; A Wang; Charles A Dinarello; P R Skolnik
Interleukin-10 enhances human immunodeficiency virus type 1 expression in a chronically infected promonocytic cell line (U1) by a tumor necrosis factor alpha-independent mechanism.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1995;15(6):575-84.
1995: Charles A Dinarello; N H Margolis
Cytokine-processing enzymes. Stopping the cuts.
Current biology : CB 1995;5(6):587-90.
1995: A E Chernoff; E V Granowitz; L Shapiro; E Vannier; Gerhard Lonnemann; J B Angel; J S Kennedy; A R Rabson; S M Wolff; Charles A Dinarello
A randomized, controlled trial of IL-10 in humans. Inhibition of inflammatory cytokine production and immune responses.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(10):5492-9.
1995: G Lonnemann; G Engler-Blum; G A Müller; K M Koch; Charles A Dinarello
Cytokines in human renal interstitial fibrosis. II. Intrinsic interleukin (IL)-1 synthesis and IL-1-dependent production of IL-6 and IL-8 by cultured kidney fibroblasts.
Kidney international 1995;47(3):845-54.
1995: G Lonnemann; L Shapiro; G Engler-Blum; G A Müller; K M Koch; Charles A Dinarello
Cytokines in human renal interstitial fibrosis. I. Interleukin-1 is a paracrine growth factor for cultured fibrosis-derived kidney fibroblasts.
Kidney international 1995;47(3):837-44.
1995: Giamila Fantuzzi; F Benigni; Marina Sironi; M Conni; M Carelli; Lavinia Cantoni; L Shapiro; Charles A Dinarello; J D Sipe; Pietro Ghezzi
Ciliary neurotrophic factor (CNTF) induces serum amyloid A, hypoglycaemia and anorexia, and potentiates IL-1 induced corticosterone and IL-6 production in mice.
Cytokine 1995;7(2):150-6.
1995: Charles A Dinarello
Interleukin-1 and interleukin-1 receptor antagonist production during haemodialysis: which cytokine is a surrogate marker for dialysis-related complications?
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1995;10 Suppl 3():25-8.
1994: Gilles Kaplanski; Catherine Farnarier; S Kaplanski; R Porat; L Shapiro; Pierre Bongrand; Charles A Dinarello
Interleukin-1 induces interleukin-8 secretion from endothelial cells by a juxtacrine mechanism.
Blood 1994;84(12):4242-8.
1994: Charles A Dinarello
The interleukin-1 family: 10 years of discovery.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1994;8(15):1314-25.
1994: L Shapiro; N Panayotatos; S N Meydani; D Wu; Charles A Dinarello
Ciliary neurotrophic factor combined with soluble receptor inhibits synthesis of proinflammatory cytokines and prostaglandin-E2 in vitro.
Experimental cell research 1994;215(1):51-6.
1994: Charles A Dinarello
The biological properties of interleukin-1.
European cytokine network 1994;5(6):517-31.
1994: Charles A Dinarello
Interleukin-1 in disease.
The Keio journal of medicine 1994;43(3):131-6.
1994: A A Santos; Mary L Rodrick; Danny O Jacobs; Charles A Dinarello; S M Wolff; John A Mannick; Douglas W Wilmore
Does the route of feeding modify the inflammatory response?
Annals of surgery 1994;220(2):155-63.
1994: E A Lynch; Charles A Dinarello; Joseph Cannon
Gender differences in IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist secretion from mononuclear cells and urinary excretion.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(1):300-6.
1994: Go Wakabayashi; Joseph Cannon; Jeffrey A Gelfand; B D Clark; K Aiura; J F Burke; S M Wolff; Charles A Dinarello
Altered interleukin-1 and tumor necrosis factor production and secretion during pyrogenic tolerance to LPS in rabbits.
The American journal of physiology 1994;267(1 Pt 2):R329-36.
1994: Charles A Dinarello
Is there a role for interleukin-1 blockade in intravenous immunoglobulin therapy?
Immunological reviews 1994;139():173-88.
1994: E Vannier; Charles A Dinarello
Histamine enhances interleukin (IL)-1-induced IL-6 gene expression and protein synthesis via H2 receptors in peripheral blood mononuclear cells.
The Journal of biological chemistry 1994;269(13):9952-6.
1994: Herbert Tilg; L Shapiro; E Vannier; D D Poutsiaka; E Trehu; Michael B Atkins; Charles A Dinarello; James W Mier
Induction of circulating antagonists to IL-1 and TNF by IL-2 administration and their effects on IL-2 induced cytokine production in vitro.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(6):3189-98.
1994: Brian J G Pereira; L Shapiro; A J King; Matthew E Falagas; J A Strom; Charles A Dinarello
Plasma levels of IL-1 beta, TNF alpha and their specific inhibitors in undialyzed chronic renal failure, CAPD and hemodialysis patients.
Kidney international 1994;45(3):890-6.
1994: Herbert Tilg; E Trehu; L Shapiro; D Pape; Michael B Atkins; Charles A Dinarello; James W Mier
Induction of circulating soluble tumour necrosis factor receptor and interleukin 1 receptor antagonist following interleukin 1 alpha infusion in humans.
Cytokine 1994;6(2):215-9.
1994: A A Santos; Jeffrey L Browning; M R Scheltinga; E A Lynch; E F Brown; P Lawton; E Chambers; I Dougas; Christopher D Benjamin; Charles A Dinarello
Are events after endotoxemia related to circulating phospholipase A2?
Annals of surgery 1994;219(2):183-92.
1994: E V Granowitz; R Porat; Jeffrey A Gelfand; S M Wolff; Charles A Dinarello
Administration of low-dose endotoxin to healthy humans increases C5a binding to circulating neutrophils.
The Journal of infectious diseases 1994;169(2):480-2.
1994: Herbert Tilg; E Trehu; Michael B Atkins; Charles A Dinarello; James W Mier
Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55.
Blood 1994;83(1):113-8.
1994: Charles A Dinarello
Interleukin-1.
Advances in pharmacology (San Diego, Calif.) 1994;25():21-51.
1994: Brian J G Pereira; Charles A Dinarello
Production of cytokines and cytokine inhibitory proteins in patients on dialysis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1994;9 Suppl 2():60-71.
1994: Brian J G Pereira; A J King; Matthew E Falagas; Charles A Dinarello
Interleukin-1 receptor antagonist: an index of dialysis-induced interleukin-1 production.
Nephron 1994;67(3):358-61.
1994: Charles A Dinarello
Blocking interleukin-1 receptors.
International journal of clinical & laboratory research 1994;24(2):61-79.
1994: R Latini; M Bianchi; E Correale; Charles A Dinarello; Giamila Fantuzzi; Claudio Fresco; Aldo P Maggioni; M Mengozzi; S Romano; L Shapiro
Cytokines in acute myocardial infarction: selective increase in circulating tumor necrosis factor, its soluble receptor, and interleukin-1 receptor antagonist.
Journal of cardiovascular pharmacology 1994;23(1):1-6.
1993: D D Poutsiaka; M Mengozzi; E Vannier; B Sinha; Charles A Dinarello
Cross-linking of the beta-glucan receptor on human monocytes results in interleukin-1 receptor antagonist but not interleukin-1 production.
Blood 1993;82(12):3695-700.
1993: S Endres; S N Meydani; R Ghorbani; R Schindler; Charles A Dinarello
Dietary supplementation with n-3 fatty acids suppresses interleukin-2 production and mononuclear cell proliferation.
Journal of leukocyte biology 1993;54(6):599-603.
1993: Herbert Tilg; W Vogel; Christian Wiedermann; L Shapiro; M Herold; G Judmaier; Charles A Dinarello
Circulating interleukin-1 and tumor necrosis factor antagonists in liver disease.
Hepatology (Baltimore, Md.) 1993;18(5):1132-8.
1993: Herbert Tilg; E Vannier; G Vachino; Charles A Dinarello; James W Mier
Antiinflammatory properties of hepatic acute phase proteins: preferential induction of interleukin 1 (IL-1) receptor antagonist over IL-1 beta synthesis by human peripheral blood mononuclear cells.
The Journal of experimental medicine 1993;178(5):1629-36.
1993: A Erroi; Giamila Fantuzzi; M Mengozzi; Marina Sironi; S F Orencole; Burton D Clark; Charles A Dinarello; A Isetta; P Gnocchi; M Giovarelli
Differential regulation of cytokine production in lipopolysaccharide tolerance in mice.
Infection and immunity 1993;61(10):4356-9.
1993: Joseph Cannon; J L Nerad; D D Poutsiaka; Charles A Dinarello
Measuring circulating cytokines.
Journal of applied physiology (Bethesda, Md. : 1985) 1993;75(4):1897-902.
1993: Herbert Tilg; D Pape; E Trehu; L Shapiro; Michael B Atkins; Charles A Dinarello; James W Mier
A method for the detection of erythrocyte-bound interleukin-8 in humans during interleukin-1 immunotherapy.
Journal of immunological methods 1993;163(2):253-8.
1993: Brian J G Pereira; A J King; D D Poutsiaka; J A Strom; Charles A Dinarello
Comparison of first use and reuse of cuprophan membranes on interleukin-1 receptor antagonist and interleukin-1 beta production by blood mononuclear cells.
American journal of kidney diseases : the official journal of the National Kidney Foundation 1993;22(2):288-95.
1993: K Aiura; Jeffrey A Gelfand; J F Burke; R C Thompson; Charles A Dinarello
Interleukin-1 (IL-1) receptor antagonist prevents Staphylococcus epidermidis-induced hypotension and reduces circulating levels of tumor necrosis factor and IL-1 beta in rabbits.
Infection and immunity 1993;61(8):3342-50.
1993: E V Granowitz; R Porat; James W Mier; S F Orencole; Gilles Kaplanski; E A Lynch; K Ye; E Vannier; S M Wolff; Charles A Dinarello
Intravenous endotoxin suppresses the cytokine response of peripheral blood mononuclear cells of healthy humans.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(3):1637-45.
1993: E Vannier; Charles A Dinarello
Histamine enhances interleukin (IL)-1-induced IL-1 gene expression and protein synthesis via H2 receptors in peripheral blood mononuclear cells. Comparison with IL-1 receptor antagonist.
The Journal of clinical investigation 1993;92(1):281-7.
1993: Charles A Dinarello
Modalities for reducing interleukin 1 activity in disease.
Immunology today 1993;14(6):260-4.
1993: L Shapiro; Burton D Clark; S F Orencole; D D Poutsiaka; E V Granowitz; Charles A Dinarello
Detection of tumor necrosis factor soluble receptor p55 in blood samples from healthy and endotoxemic humans.
The Journal of infectious diseases 1993;167(6):1344-50.
1993: Flavio Coceani; J Lees; J Mancilla; J Belizario; Charles A Dinarello
Interleukin-6 and tumor necrosis factor in cerebrospinal fluid: changes during pyrogen fever.
Brain research 1993;612(1-2):165-71.
1993: Gilles Kaplanski; R Porat; K Aiura; J K Erban; Jeffrey A Gelfand; Charles A Dinarello
Activated platelets induce endothelial secretion of interleukin-8 in vitro via an interleukin-1-mediated event.
Blood 1993;81(10):2492-5.
1993: Herbert Tilg; James W Mier; W Vogel; Walter Aulitzky; Christian Wiedermann; E Vannier; C Huber; Charles A Dinarello
Induction of circulating IL-1 receptor antagonist by IFN treatment.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(10):4687-92.
1993: Charles A Dinarello
Modalities for reducing interleukin 1 activity in disease.
Trends in pharmacological sciences 1993;14(5):155-9.
1993: Charles A Dinarello; Jeffrey A Gelfand; S M Wolff
Anticytokine strategies in the treatment of the systemic inflammatory response syndrome.
JAMA : the journal of the American Medical Association 1993;269(14):1829-35.
1993: K Ye; Charles A Dinarello; Burton D Clark
Identification of the promoter region of human interleukin 1 type I receptor gene: multiple initiation sites, high G+C content, and constitutive expression.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(6):2295-9.
1993: R Schindler; S Linnenweber; M Schulze; Martin Oppermann; Charles A Dinarello; S Shaldon; Karl-Martin Koch
Gene expression of interleukin-1 beta during hemodialysis.
Kidney international 1993;43(3):712-21.
1993: J Mancilla; P García; Charles A Dinarello
The interleukin-1 receptor antagonist can either reduce or enhance the lethality of Klebsiella pneumoniae sepsis in newborn rats.
Infection and immunity 1993;61(3):926-32.
1993: A A Santos; M R Scheltinga; E Lynch; E F Brown; P Lawton; E Chambers; J Browning; Charles A Dinarello; S M Wolff; Douglas W Wilmore
Elaboration of interleukin 1-receptor antagonist is not attenuated by glucocorticoids after endotoxemia.
Archives of surgery (Chicago, Ill. : 1960) 1993;128(2):138-43; discussion 143-4.
1993: L C Miller; E A Lynch; S Isa; J W Logan; Charles A Dinarello; A C Steere
Balance of synovial fluid IL-1 beta and IL-1 receptor antagonist and recovery from Lyme arthritis.
Lancet 1993;341(8838):146-8.
1993: Charles A Dinarello; S M Wolff
The role of interleukin-1 in disease.
The New England journal of medicine 1993;328(2):106-13.
1993: Charles A Dinarello
Blocking interleukin-1 in disease.
Blood purification 1993;11(2):118-27.
1992: Brian J G Pereira; D D Poutsiaka; A J King; J A Strom; G Narayan; A S Levey; Charles A Dinarello
In vitro production of interleukin-1 receptor antagonist in chronic renal failure, CAPD and HD.
Kidney international 1992;42(6):1419-24.
1992: J L Nerad; Jeffrey Griffiths; J W Van der Meer; S Endres; D D Poutsiaka; Gerald T Keusch; Michael Bennish; M A Salam; Charles A Dinarello; Joseph Cannon
Interleukin-1 beta (IL-1 beta), IL-1 receptor antagonist, and TNF alpha production in whole blood.
Journal of leukocyte biology 1992;52(6):687-92.
1992: E V Granowitz; R Porat; S F Orencole; M V Callahan; E A Lynch; S M Wolff; Charles A Dinarello
Granulocyte-macrophage colony-stimulating factor synthesis during experimental endotoxemia in humans.
The Journal of infectious diseases 1992;166(5):1204-5.
1992: R P Numerof; J D Sipe; E G Trehu; Charles A Dinarello; James W Mier
Suppression of IL-2-induced SAA gene expression in mice by the administration of an IL-1 receptor antagonist.
Cytokine 1992;4(6):555-60.
1992: Charles A Dinarello
The role of interleukin-1 in host responses to infectious diseases.
Infectious agents and disease 1992;1(5):227-36.
1992: Charles A Dinarello
Interleukin-1 and tumor necrosis factor and their naturally occurring antagonists during hemodialysis.
Kidney international. Supplement 1992;38():S68-77.
1992: E V Granowitz; R Porat; James W Mier; John P Pribble; D M Stiles; D C Bloedow; M A Catalano; S M Wolff; Charles A Dinarello
Pharmacokinetics, safety and immunomodulatory effects of human recombinant interleukin-1 receptor antagonist in healthy humans.
Cytokine 1992;4(5):353-60.
1992: L C Miller; S Isa; E Vannier; K Georgilis; A C Steere; Charles A Dinarello
Live Borrelia burgdorferi preferentially activate interleukin-1 beta gene expression and protein synthesis over the interleukin-1 receptor antagonist.
The Journal of clinical investigation 1992;90(3):906-12.
1992: J Mancilla; T Ikejima; Charles A Dinarello
Glycosylation of the interleukin-1 receptor type I is required for optimal binding of interleukin-1.
Lymphokine and cytokine research 1992;11(4):197-205.
1992: N A Katzen; G M Segal; E Vannier; J L Nerad; M S Klempner; Charles A Dinarello
Comparison of granulocyte-macrophage colony stimulating factor and interleukin-1 production from human peripheral blood mononuclear cells as measured by specific radioimmunoassays.
European cytokine network 1992;3(4):365-72.
1992: Charles A Dinarello
Dissociation of transcription from translation of human IL-1 beta: induction of steady state mRNA by adherence or recombinant C5a in the absence of translation.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1992;200(2):228-32.
1992: Charles A Dinarello
Role of interleukin-1 in infectious diseases.
Immunological reviews 1992;127():119-46.
1992: Charles A Dinarello
Interleukin-1 and tumor necrosis factor: effector cytokines in autoimmune diseases.
Seminars in immunology 1992;4(3):133-45.
1992: E V Granowitz; E Vannier; D D Poutsiaka; Charles A Dinarello
Effect of interleukin-1 (IL-1) blockade on cytokine synthesis: II. IL-1 receptor antagonist inhibits lipopolysaccharide-induced cytokine synthesis by human monocytes.
Blood 1992;79(9):2364-9.
1992: E V Granowitz; Burton D Clark; E Vannier; M V Callahan; Charles A Dinarello
Effect of interleukin-1 (IL-1) blockade on cytokine synthesis: I. IL-1 receptor antagonist inhibits IL-1-induced cytokine synthesis and blocks the binding of IL-1 to its type II receptor on human monocytes.
Blood 1992;79(9):2356-63.
1992: E Vannier; L C Miller; Charles A Dinarello
Coordinated antiinflammatory effects of interleukin 4: interleukin 4 suppresses interleukin 1 production but up-regulates gene expression and synthesis of interleukin 1 receptor antagonist.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(9):4076-80.
1992: Charles A Dinarello
ELISA kits based on monoclonal antibodies do not measure total IL-1 beta synthesis.
Journal of immunological methods 1992;148(1-2):255-9.
1992: R Porat; D D Poutsiaka; L C Miller; E V Granowitz; Charles A Dinarello
Interleukin-1 (IL-1) receptor blockade reduces endotoxin and Borrelia burgdorferi-stimulated IL-8 synthesis in human mononuclear cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1992;6(7):2482-6.
1992: K Ye; K C Koch; Burton D Clark; Charles A Dinarello
Interleukin-1 down-regulates gene and surface expression of interleukin-1 receptor type I by destabilizing its mRNA whereas interleukin-2 increases its expression.
Immunology 1992;75(3):427-34.
1992: Charles A Dinarello
Anti-cytokine strategies.
European cytokine network 1992;3(1):7-17.
1992: Charles A Dinarello
The biology of interleukin-1.
Chemical immunology 1992;51():1-32.
1992: K C Koch; K Ye; Burton D Clark; Charles A Dinarello
Interleukin 4 (IL) 4 up-regulates gene and surface IL 1 receptor type I in murine T helper type 2 cells.
European journal of immunology 1992;22(1):153-7.
1992: Charles A Dinarello
Reduction of inflammation by decreasing production of interleukin-1 or by specific receptor antagonism.
International journal of tissue reactions 1992;14(2):65-75.
1991: E V Granowitz; A A Santos; D D Poutsiaka; Joseph Cannon; Douglas W Wilmore; S M Wolff; Charles A Dinarello
Production of interleukin-1-receptor antagonist during experimental endotoxaemia.
Lancet 1991;338(8780):1423-4.
1991: Burton D Clark; I Bedrosian; R Schindler; Fabio Cominelli; Joseph Cannon; A R Shaw; Charles A Dinarello
Detection of interleukin 1 alpha and 1 beta in rabbit tissues during endotoxemia using sensitive radioimmunoassays.
Journal of applied physiology (Bethesda, Md. : 1985) 1991;71(6):2412-8.
1991: I Bedrosian; R D Sofia; S M Wolff; Charles A Dinarello
Taurolidine, an analogue of the amino acid taurine, suppresses interleukin 1 and tumor necrosis factor synthesis in human peripheral blood mononuclear cells.
Cytokine 1991;3(6):568-75.
1991: Charles A Dinarello; Joseph Cannon; J Mancilla; I Bishai; J Lees; Flavio Coceani
Interleukin-6 as an endogenous pyrogen: induction of prostaglandin E2 in brain but not in peripheral blood mononuclear cells.
Brain research 1991;562(2):199-206.
1991: R Porat; B D Clark; S M Wolff; Charles A Dinarello
Enhancement of growth of virulent strains of Escherichia coli by interleukin-1.
Science (New York, N.Y.) 1991;254(5030):430-2.
1991: D D Poutsiaka; Burton D Clark; E Vannier; Charles A Dinarello
Production of interleukin-1 receptor antagonist and interleukin-1 beta by peripheral blood mononuclear cells is differentially regulated.
Blood 1991;78(5):1275-81.
1991: E V Granowitz; Burton D Clark; J Mancilla; Charles A Dinarello
Interleukin-1 receptor antagonist competitively inhibits the binding of interleukin-1 to the type II interleukin-1 receptor.
The Journal of biological chemistry 1991;266(22):14147-50.
1991: E Vannier; L C Miller; Charles A Dinarello
Histamine suppresses gene expression and synthesis of tumor necrosis factor alpha via histamine H2 receptors.
The Journal of experimental medicine 1991;174(1):281-4.
1991: Go Wakabayashi; Jeffrey A Gelfand; W K Jung; R J Connolly; J F Burke; Charles A Dinarello
Staphylococcus epidermidis induces complement activation, tumor necrosis factor and interleukin-1, a shock-like state and tissue injury in rabbits without endotoxemia. Comparison to Escherichia coli.
The Journal of clinical investigation 1991;87(6):1925-35.
1991: Charles A Dinarello
The proinflammatory cytokines interleukin-1 and tumor necrosis factor and treatment of the septic shock syndrome.
The Journal of infectious diseases 1991;163(6):1177-84.
1991: J E Belizario; Charles A Dinarello
Interleukin 1, interleukin 6, tumor necrosis factor, and transforming growth factor beta increase cell resistance to tumor necrosis factor cytotoxicity by growth arrest in the G1 phase of the cell cycle.
Cancer research 1991;51(9):2379-85.
1991: Charles A Dinarello
Interleukin-1 and interleukin-1 antagonism.
Blood 1991;77(8):1627-52.
1991: Go Wakabayashi; Jeffrey A Gelfand; J F Burke; R C Thompson; Charles A Dinarello
A specific receptor antagonist for interleukin 1 prevents Escherichia coli-induced shock in rabbits.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1991;5(3):338-43.
1991: M Morin; R Schindler; Go Wakabayashi; G Daumy; Charles A Dinarello; Jeffrey A Gelfand
Picogram concentrations of endotoxin stimulate synthesis of IL-1 beta and TNF alpha by human peripheral blood mononuclear cells exposed to recombinant human C5a.
European cytokine network 1991;2(1):27-30.
1990: R Schindler; Jeffrey A Gelfand; Charles A Dinarello
Recombinant C5a stimulates transcription rather than translation of interleukin-1 (IL-1) and tumor necrosis factor: translational signal provided by lipopolysaccharide or IL-1 itself.
Blood 1990;76(8):1631-8.
1990: R P Numerof; A N Kotik; Charles A Dinarello; James W Mier
Pro-interleukin-1 beta production by a subpopulation of human T cells, but not NK cells, in response to interleukin-2.
Cellular immunology 1990;130(1):118-28.
1990: T Ikejima; S Okusawa; P Ghezzi; J W van der Meer; Charles A Dinarello
Interleukin-1 induces tumor necrosis factor (TNF) in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits.
The Journal of infectious diseases 1990;162(1):215-23.
1990: R Schindler; Burton D Clark; Charles A Dinarello
Dissociation between interleukin-1 beta mRNA and protein synthesis in human peripheral blood mononuclear cells.
The Journal of biological chemistry 1990;265(18):10232-7.
1990: James I Koenig; K Snow; B D Clark; Roberto Toni; Joseph Cannon; A R Shaw; Charles A Dinarello; S Reichlin; S L Lee; Ronald M Lechan
Intrinsic pituitary interleukin-1 beta is induced by bacterial lipopolysaccharide.
Endocrinology 1990;126(6):3053-8.
1990: Ronald M Lechan; Roberto Toni; B D Clark; Joseph Cannon; A R Shaw; Charles A Dinarello; S Reichlin
Immunoreactive interleukin-1 beta localization in the rat forebrain.
Brain research 1990;514(1):135-40.
1990: R Schindler; Pietro Ghezzi; Charles A Dinarello
IL-1 induces IL-1. IV. IFN-gamma suppresses IL-1 but not lipopolysaccharide-induced transcription of IL-1.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(6):2216-22.
1990: Charles A Dinarello; Burton D Clark; T Ikejima; A J Puren; N Savage; P M Rosoff
Interleukin 1 receptors and biological responses.
The Yale journal of biology and medicine 1990;63(2):87-93.
1990: R Schindler; Gerhard Lonnemann; stanley shaldon; Karl-Martin Koch; Charles A Dinarello
Transcription, not synthesis, of interleukin-1 and tumor necrosis factor by complement.
Kidney international 1990;37(1):85-93.
1990: R Schindler; J Mancilla; S Endres; R Ghorbani; S C Clark; Charles A Dinarello
Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF.
Blood 1990;75(1):40-7.
1990: Charles A Dinarello; R Schindler
Dissociation of transcription from translation of human IL-1-beta: the induction of steady state mRNA by adherence or recombinant C5a in the absence of translation.
Progress in clinical and biological research 1990;349():195-204.
1990: Charles A Dinarello; S Endres; S N Meydani; M Meydani; M K Hellerstein
Interleukin-1, anorexia, and dietary fatty acids.
Annals of the New York Academy of Sciences 1990;587():332-8.
1990: Charles A Dinarello
Cytokines and biocompatibility.
Blood purification 1990;8(4):208-13.
1990: Charles A Dinarello
Interleukin-1 and inhibition of interleukin-1 in hemodialysis patients.
Contributions to nephrology 1990;86():48-69; discussion 69-72.
1989: S Endres; Joseph G Cannon; R Ghorbani; R A Dempsey; Stephen D Sisson; G Lonnemann; J W Van der Meer; S M Wolff; Charles A Dinarello
In vitro production of IL 1 beta, IL 1 alpha, TNF and IL2 in healthy subjects: distribution, effect of cyclooxygenase inhibition and evidence of independent gene regulation.
European journal of immunology 1989;19(12):2327-33.
1989: N Savage; A J Puren; S F Orencole; T Ikejima; Burton D Clark; Charles A Dinarello
Studies on IL-1 receptors on D10S T-helper cells: demonstration of two molecularly and antigenically distinct IL-1 binding proteins.
Cytokine 1989;1(1):23-35.
1989: S F Orencole; Charles A Dinarello
Characterization of a subclone (D10S) of the D10.G4.1 helper T-cell line which proliferates to attomolar concentrations of interleukin-1 in the absence of mitogens.
Cytokine 1989;1(1):14-22.
1989: G Lonnemann; S Endres; J W Van der Meer; Joseph Cannon; K M Koch; Charles A Dinarello
Differences in the synthesis and kinetics of release of interleukin 1 alpha, interleukin 1 beta and tumor necrosis factor from human mononuclear cells.
European journal of immunology 1989;19(9):1531-6.
1989: Joseph Cannon; R A Fielding; MA Fiatarone; S F Orencole; Charles A Dinarello; William J Evans
Increased interleukin 1 beta in human skeletal muscle after exercise.
The American journal of physiology 1989;257(2 Pt 2):R451-5.
1989: E A Whitcomb; Charles A Dinarello; S H Pincus
Differential effects of interleukin-1 alpha and interleukin-1 beta on human peripheral blood eosinophils.
Blood 1989;73(7):1904-8.
1989: Joseph Cannon; B D Clark; P Wingfield; U Schmeissner; C Losberger; Charles A Dinarello; A R Shaw
Rabbit IL-1. Cloning, expression, biologic properties, and transcription during endotoxemia.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(7):2299-306.
1989: S Prakash; Charles A Dinarello; K Danko; Miguel J Stadecker; D J Wyler
Schistosomal egg granuloma-derived fibroblast-stimulating factor is apparently distinct from interleukin-1.
Infection and immunity 1989;57(3):679-84.
1989: Charles A Dinarello; Burton D Clark; A J Puren; N Savage; P M Rosoff
The interleukin 1 receptor.
Immunology today 1989;10(2):49-51.
1989: R Schindler; Charles A Dinarello
A method for removing interleukin-1- and tumor necrosis factor-inducing substances from bacterial cultures by ultrafiltration with polysulfone.
Journal of immunological methods 1989;116(2):159-65.
1989: Charles A Dinarello; S Okusawa; Jeffrey A Gelfand
Interleukin-1 induces a shock-like state in rabbits: synergism with tumor necrosis factor and the effect of ibuprofen.
Progress in clinical and biological research 1989;299():203-15.
1989: D E Scarborough; S L Lee; Charles A Dinarello; S Reichlin
Interleukin-1 beta stimulates somatostatin biosynthesis in primary cultures of fetal rat brain.
Endocrinology 1989;124(1):549-51.
1989: Charles A Dinarello; S F Orencole; N Savage
Interleukin-1 induced T-lymphocyte proliferation and its relation to IL-1 receptors.
Advances in experimental medicine and biology 1989;254():45-53.
1989: Charles A Dinarello; S Okusawa; Jeffrey A Gelfand
Interleukin-1 induces a shock-like state in rabbits: synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition.
Progress in clinical and biological research 1989;286():243-63.
1989: R Schindler; Pietro Ghezzi; Charles A Dinarello
Interferons as inhibitors of interleukin 1 induced interleukin 1 synthesis.
Lymphokine research 1989;8(3):275-80.
1989: Charles A Dinarello
Interleukin-1 and its biologically related cytokines.
Advances in immunology 1989;44():153-205.
1988: E E Tredget; YM Yu; S Zhong; R Burini; S Okusawa; Jeffrey A Gelfand; Charles A Dinarello; Vernon R Young; J F Burke
Role of interleukin 1 and tumor necrosis factor on energy metabolism in rabbits.
The American journal of physiology 1988;255(6 Pt 1):E760-8.
1988: S Endres; R Ghorbani; G Lonnemann; J W van der Meer; Charles A Dinarello
Measurement of immunoreactive interleukin-1 beta from human mononuclear cells: optimization of recovery, intrasubject consistency, and comparison with interleukin-1 alpha and tumor necrosis factor.
Clinical immunology and immunopathology 1988;49(3):424-38.
1988: James W Mier; G Vachino; J W van der Meer; R P Numerof; S Adams; Joseph Cannon; H A Bernheim; Michael B Atkins; D R Parkinson; Charles A Dinarello
Induction of circulating tumor necrosis factor (TNF alpha) as the mechanism for the febrile response to interleukin-2 (IL-2) in cancer patients.
Journal of clinical immunology 1988;8(6):426-36.
1988: T Ikejima; S Okusawa; J W van der Meer; Charles A Dinarello
Induction by toxic-shock-syndrome toxin-1 of a circulating tumor necrosis factor-like substance in rabbits and of immunoreactive tumor necrosis factor and interleukin-1 from human mononuclear cells.
The Journal of infectious diseases 1988;158(5):1017-25.
1988: Stephen D Sisson; Charles A Dinarello
Production of interleukin-1 alpha, interleukin-1 beta and tumor necrosis factor by human mononuclear cells stimulated with granulocyte-macrophage colony-stimulating factor.
Blood 1988;72(4):1368-74.
1988: H R Michie; David Spriggs; K R Manogue; M L Sherman; A Revhaug; S T O'Dwyer; K Arthur; Charles A Dinarello; A Cerami; S M Wolff
Tumor necrosis factor and endotoxin induce similar metabolic responses in human beings.
Surgery 1988;104(2):280-6.
1988: S Okusawa; K B Yancey; J W van der Meer; S Endres; G Lonnemann; K Hefter; M M Frank; J F Burke; Charles A Dinarello; Jeffrey A Gelfand
C5a stimulates secretion of tumor necrosis factor from human mononuclear cells in vitro. Comparison with secretion of interleukin 1 beta and interleukin 1 alpha.
The Journal of experimental medicine 1988;168(1):443-8.
1988: Pietro Ghezzi; Charles A Dinarello
IL-1 induces IL-1. III. Specific inhibition of IL-1 production by IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(12):4238-44.
1988: H R Michie; K R Manogue; David Spriggs; A Revhaug; S O'Dwyer; Charles A Dinarello; A Cerami; S M Wolff; Douglas W Wilmore
Detection of circulating tumor necrosis factor after endotoxin administration.
The New England journal of medicine 1988;318(23):1481-6.
1988: Flavio Coceani; J Lees; Charles A Dinarello
Occurrence of interleukin-1 in cerebrospinal fluid of the conscious cat.
Brain research 1988;446(2):245-50.
1988: S Okusawa; Jeffrey A Gelfand; T Ikejima; R J Connolly; Charles A Dinarello
Interleukin 1 induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition.
The Journal of clinical investigation 1988;81(4):1162-72.
1988: Charles A Dinarello; Karl-Martin Koch; S Shaldon
Interleukin-1 and its relevance in patients treated with hemodialysis.
Kidney international. Supplement 1988;24():S21-6.
1988: J W van der Meer; S Endres; G Lonnemann; Joseph Cannon; T Ikejima; S Okusawa; J A Gelfand; Charles A Dinarello
Concentrations of immunoreactive human tumor necrosis factor alpha produced by human mononuclear cells in vitro.
Journal of leukocyte biology 1988;43(3):216-23.
1988: Charles A Dinarello
Interleukin-1.
Digestive diseases and sciences 1988;33(3 Suppl):25S-35S.
1988: J W van der Meer; M Barza; S M Wolff; Charles A Dinarello
A low dose of recombinant interleukin 1 protects granulocytopenic mice from lethal gram-negative infection.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(5):1620-3.
1988: Charles A Dinarello
Biology of interleukin 1.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1988;2(2):108-15.
1988: A Revhaug; H R Michie; J M Manson; James M Watters; Charles A Dinarello; S M Wolff; Douglas W Wilmore
Inhibition of cyclo-oxygenase attenuates the metabolic response to endotoxin in humans.
Archives of surgery (Chicago, Ill. : 1960) 1988;123(2):162-70.
1988: Charles A Dinarello
Interleukin-1--its multiple biological effects and its association with hemodialysis.
Blood purification 1988;6(3):164-72.
1988: S Shaldon; Charles A Dinarello; M Elie; Karl-Martin Koch
Interleukin-1 and biocompatibility in haemodialysis.
Contributions to nephrology 1988;62():128-31.
1988: Gerhard Lonnemann; M Bingel; Jürgen Floege; Karl-Martin Koch; S Shaldon; Charles A Dinarello
Detection of endotoxin-like interleukin-1-inducing activity during in vitro dialysis.
Kidney international 1988;33(1):29-35.
1988: M Bingel; Gerhard Lonnemann; Karl-Martin Koch; Charles A Dinarello; S Shaldon
Plasma interleukin-1 activity during hemodialysis: the influence of dialysis membranes.
Nephron 1988;50(4):273-6.
1988: Gerhard Lonnemann; Stefan Endres; J W van der Meer; Joseph Cannon; Charles A Dinarello
A radioimmunoassay for human interleukin-1 alpha: measurement of IL-1 alpha produced in vitro by human blood mononuclear cells stimulated with endotoxin.
Lymphokine research 1988;7(2):75-84.
1988: S Shaldon; Karl-Martin Koch; Charles A Dinarello
Interleukin-1 activation and acute phase response during hemodialysis.
Contributions to nephrology 1988;61():18-26.
1988: S Shaldon; Charles A Dinarello; Karl-Martin Koch; Gerhard Lonnemann; M Bingel; Céline Granolleras; G Deschodt; B Branger; R Oulès; J Fourcade
Interleukin-1 and dialysis.
Advances in nephrology from the Necker Hospital 1988;17():423-34.
1988: Charles A Dinarello
Interleukin-1.
Annals of the New York Academy of Sciences 1988;546():122-32.
1988: Charles A Dinarello; Joseph Cannon; S M Wolff
New concepts on the pathogenesis of fever.
Reviews of infectious diseases 1988;10(1):168-89.
1987: Charles A Dinarello
The biology of interleukin 1 and comparison to tumor necrosis factor.
Immunology letters 1987;16(3-4):227-31.
1987: I Bishai; Charles A Dinarello; Flavio Coceani
Prostaglandin formation in feline cerebral microvessels: effect of endotoxin and interleukin-1.
Canadian journal of physiology and pharmacology 1987;65(11):2225-30.
1987: S Okusawa; Charles A Dinarello; K B Yancey; S Endres; T J Lawley; M M Frank; J F Burke; Jeffrey A Gelfand
C5a induction of human interleukin 1. Synergistic effect with endotoxin or interferon-gamma.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(8):2635-40.
1987: S Shaldon; Charles A Dinarello
The relationship between biocompatibility and interleukin-1.
Life support systems : the journal of the European Society for Artificial Organs 1987;5(4):341-5.
1987: S Shaldon; M Elie; Karl-Martin Koch; Charles A Dinarello
Interleukin-1 stimulation in the ESRD patient: potential long-term consequences.
Transplantation proceedings 1987;19(5):4353-7.
1987: Charles A Dinarello; T Ikejima; S J Warner; S F Orencole; G Lonnemann; Joseph Cannon; P Libby
Interleukin 1 induces interleukin 1. I. Induction of circulating interleukin 1 in rabbits in vivo and in human mononuclear cells in vitro.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(6):1902-10.
1987: Philip E. auron; S J Warner; A C Webb; Joseph Cannon; H A Bernheim; K J McAdam; L J Rosenwasser; G LoPreste; S F Mucci; Charles A Dinarello
Studies on the molecular nature of human interleukin 1.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(5):1447-56.
1987: M Bingel; Gerhard Lonnemann; Karl-Martin Koch; Charles A Dinarello; S Shaldon
Enhancement of in-vitro human interleukin-1 production by sodium acetate.
Lancet 1987;1(8523):14-6.
1987: Gerhard Lonnemann; M Bingel; K M Koch; S Shaldon; Charles A Dinarello
Plasma interleukin-1 activity in humans undergoing hemodialysis with regenerated cellulosic membranes.
Lymphokine research 1987;6(2):63-70.
1987: S Shaldon; Charles A Dinarello; D J Wyler
Induction of interleukin-1 during CAPD.
Contributions to nephrology 1987;57():207-12.
1987: Charles A Dinarello; Gerhard Lonnemann; M Bingel; Karl-Martin Koch; S Shaldon
Biological consequences of monocyte activation during hemodialysis.
Contributions to nephrology 1987;59():1-9.
1987: Charles A Dinarello
Interleukin-1: multiple biological properties and mechanisms of action.
Advances in prostaglandin, thromboxane, and leukotriene research 1987;17B():900-4.
1986: S H Pincus; E A Whitcomb; Charles A Dinarello
Interaction of IL 1 and TPA in modulation of eosinophil function.
Journal of immunology (Baltimore, Md. : 1950) 1986;137(11):3509-14.
1986: Charles A Dinarello; R A Dempsey; M Allegretta; G LoPreste; N Dainiak; D R Parkinson; James W Mier
Inhibitory effects of elevated temperature on human cytokine production and natural killer activity.
Cancer research 1986;46(12 Pt 1):6236-41.
1986: Charles A Dinarello; Joseph Cannon; James W Mier; H A Bernheim; G LoPreste; D L Lynn; R N Love; A C Webb; Philip E. auron; R C Reuben
Multiple biological activities of human recombinant interleukin 1.
The Journal of clinical investigation 1986;77(6):1734-9.
1986: M Bingel; Gerhard Lonnemann; S Shaldon; Karl-Martin Koch; Charles A Dinarello
Human interleukin-1 production during hemodialysis.
Nephron 1986;43(3):161-3.
1985: James W Mier; L M Souza; M Allegretta; T Boone; H A Bernheim; Charles A Dinarello
Dissimilarities between purified human interleukin-1 and recombinant human interleukin-2 in the induction of fever, brain prostaglandin, and acute-phase protein synthesis.
Journal of biological response modifiers 1985;4(1):35-45.
1982: R A Dempsey; Charles A Dinarello; James W Mier; L J Rosenwasser; M Allegretta; T E Brown; D R Parkinson
The differential effects of human leukocyte pyrogen/lymphocyte-activating factor, T cell growth factor, and interferon on human natural killer activity.
Journal of immunology (Baltimore, Md. : 1950) 1982;129(6):2504-10.