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Sheng Ding

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TOP 3
Janghwan Kim; Rajesh Ambasudhan; Sheng Ding
Direct lineage reprogramming to neural cells.
Hairi Li; Xiangqiang Li; Jinsong Qiu; Michael G Rosenfeld; Dong Wang; Hongyan Zhou; Yu Zhou; Sheng Ding; Xiang-Dong Fu
Versatile pathway-centric approach based on high-throughput sequencing to anticancer drug discovery.
Tim U Ukrohne; Junhua Wang; Peter D Westenskow; Saiyong Zhu; Sheng Ding; Alison L Dorsey; David F Friedlander; Toshihide Kurihara; Mandy Lehmann; Wenlin Li; Andrew Schultz; Gary Siuzdak; Martin Friedlander
Generation of retinal pigment epithelial cells from small molecules and OCT4 reprogrammed human induced pluripotent stem cells.

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All Publications

2012: Janghwan Kim; Rajesh Ambasudhan; Sheng Ding
Direct lineage reprogramming to neural cells.
Current opinion in neurobiology 2012;22(5):778-84.
2012: Hairi Li; Xiangqiang Li; Jinsong Qiu; Michael G Rosenfeld; Dong Wang; Hongyan Zhou; Yu Zhou; Sheng Ding; Xiang-Dong Fu
Versatile pathway-centric approach based on high-throughput sequencing to anticancer drug discovery.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(12):4609-14.
2012: Tim U Ukrohne; Junhua Wang; Peter D Westenskow; Saiyong Zhu; Sheng Ding; Alison L Dorsey; David F Friedlander; Toshihide Kurihara; Mandy Lehmann; Wenlin Li; Andrew Schultz; Gary Siuzdak; Martin Friedlander
Generation of retinal pigment epithelial cells from small molecules and OCT4 reprogrammed human induced pluripotent stem cells.
Stem cells translational medicine 2012;1(2):96-109.
2012: Peter D Westenskow; Yang Xu; Zhen-Ning Zhang; Tongbiao Zhao; Saiyong Zhu; Sheng Ding; Tim Krohne; Toshihide Kurihara; Stacey K Moreno; Martin Friedlander
Using flow cytometry to compare the dynamics of photoreceptor outer segment phagocytosis in iPS-derived RPE cells.
Investigative ophthalmology & visual science 2012;53(10):6282-90.
2011: Jun Liu; Ken Muneoka; Nicholas Ng; Victoria Piamonte; Sheng Ding; Richard Glynne; Mindy H Hsieh; Kristen Johnson; Jie Li; Brian M Steffy; John R Walker; Xu Wu; Jay Zhang; Peter G Schultz
Regenerative phenotype in mice with a point mutation in transforming growth factor beta type I receptor (TGFBR1).
Proceedings of the National Academy of Sciences of the United States of America 2011;108(35):14560-5.
2011: Jem A Efe; Sheng Ding
The evolving biology of small molecules: controlling cell fate and identity.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2011;366(1575):2208-21.
2011: Rajesh Ambasudhan; Ronald Coleman; Stuart A Lipton; Maria Talantova; Xu Yuan; Saiyong Zhu; Sheng Ding
Direct reprogramming of adult human fibroblasts to functional neurons under defined conditions.
Cell stem cell 2011;9(2):113-8.
2011: Jem A Efe; Sheng Ding
Reprogramming, transdifferentiation and the shifting landscape of cellular identity.
Cell cycle (Georgetown, Tex.) 2011;10(12):1886-7.
2011: Wenlin Li; Woong Sun; Yu Zhang; Wanguo Wei; Rajesh Ambasudhan; Peng Xia; Maria Talantova; Tongxiang Lin; Janghwan Kim; Xiaolei Wang; Woon Ryoung Kim; Stuart A Lipton; Kang Zhang; Sheng Ding
Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(20):8299-304.
2011: Janghwan Kim; Jem A Efe; Saiyong Zhu; Maria Talantova; Xu Yuan; Shufen Wang; Stuart A Lipton; Kang Zhang; Sheng Ding
Direct reprogramming of mouse fibroblasts to neural progenitors.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(19):7838-43.
2011: Wenlin Li; Sheng Ding
Human pluripotent stem cells: decoding the naïve state.
Science translational medicine 2011;3(76):76ps10.
2011: Saiyong Zhu; Tianhua Ma; Jun Li; Sheng Ding
Recent advances in chemically induced reprogramming.
Cell cycle (Georgetown, Tex.) 2011;10(6):871-2.
2011: Xu Yuan; Haifeng Wan; Xiaoyang Zhao; Saiyong Zhu; Qi Zhou; Sheng Ding
Brief report: combined chemical treatment enables Oct4-induced reprogramming from mouse embryonic fibroblasts.
Stem cells (Dayton, Ohio) 2011;29(3):549-53.
2011: Jem A Efe; Simon Hilcove; Janghwan Kim; Hongyan Zhou; Kunfu Ouyang; Gang Wang; Ju Chen; Sheng Ding
Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy.
Nature cell biology 2011;13(3):215-22.
2011: Jem A Efe; Kai Jiang; Xu Yuan; Sheng Ding
Development unchained: how cellular reprogramming is redefining our view of cell fate and identity.
Science progress 2011;94(Pt 3):298-322.
2011: Xu Yuan; Wenlin Li; Sheng Ding
Small molecules in cellular reprogramming and differentiation.
Progress in drug research. Fortschritte der Arzneimittelforschung. Progrès des recherches pharmaceutiques 2011;67():253-66.
2010: Saiyong Zhu; Wenlin Li; Hongyan Zhou; Wanguo Wei; Rajesh Ambasudhan; Tongxiang Lin; Janghwan Kim; Kang Zhang; Sheng Ding
Reprogramming of human primary somatic cells by OCT4 and chemical compounds.
Cell stem cell 2010;7(6):651-5.
2010: Hongyan Zhou; Wenlin Li; Saiyong Zhu; Jin Young Joo; Jeong Tae Do; Wen Xiong; Jeong Beom Kim; Kang Zhang; Hans R Schöler; Sheng Ding
Conversion of mouse epiblast stem cells to an earlier pluripotency state by small molecules.
The Journal of biological chemistry 2010;285(39):29676-80.
2010: Ramzey Abujarour; Jem Efe; Sheng Ding
Genome-wide gain-of-function screen identifies novel regulators of pluripotency.
Stem cells (Dayton, Ohio) 2010;28(9):1487-97.
2010: Hongyan Zhou; Sheng Ding
Evolution of induced pluripotent stem cell technology.
Current opinion in hematology 2010;17(4):276-80.
2010: Ian Lian; Joungmok Kim; Hideki Okazawa; Jiagang Zhao; Bin Zhao; Jindan YU; Arul M Chinnaiyan; Mason A Israel; Lawrence S B Goldstein; Ramzey Abujarour; Sheng Ding; Kun-Liang Guan
The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation.
Genes & development 2010;24(11):1106-18.
2010: Yue Xu; Xiuwen Zhu; Heung Sik Hahm; Wanguo Wei; Ergeng Hao; Alberto Hayek; Sheng Ding
Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(18):8129-34.
2010: Wenlin Li; Sheng Ding
Generation of novel rat and human pluripotent stem cells by reprogramming and chemical approaches.
Methods in molecular biology (Clifton, N.J.) 2010;636():293-300.
2010: Caroline Desponts; Sheng Ding
Using small molecules to improve generation of induced pluripotent stem cells from somatic cells.
Methods in molecular biology (Clifton, N.J.) 2010;636():207-18.
2010: Wenlin Li; Sheng Ding
Small molecules that modulate embryonic stem cell fate and somatic cell reprogramming.
Trends in pharmacological sciences 2010;31(1):36-45.
2009: Wenlin Li; HongYan Zhou; Ramzey Abujarour; Saiyong Zhu; Jin Young Joo; Tongxiang Lin; Ergeng Hao; Hans R Schöler; Alberto Hayek; Sheng Ding
Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2.
Stem cells (Dayton, Ohio) 2009;27(12):2992-3000.
2009: Tongxiang Lin; Rajesh Ambasudhan; Xu Yuan; Wenlin Li; Simon Hilcove; Ramzey Abujarour; Xiangyi Lin; Heung Sik Hahm; Ergeng Hao; Alberto Hayek; Sheng Ding
A chemical platform for improved induction of human iPSCs.
Nature methods 2009;6(11):805-8.
2009: Hongyan Zhou; Shili Wu; Jin Young Joo; Saiyong Zhu; Dong Wook Han; Tongxiang Lin; Sunia Trauger; Geoffery Bien; Susan Yao; Yong Zhu; Gary Siuzdak; Hans R Schöler; Lingxun Duan; Sheng Ding
Generation of induced pluripotent stem cells using recombinant proteins.
Cell stem cell 2009;4(5):381-4.
2009: Wenlin Li; Wei Wei; Saiyong Zhu; Jinliang Zhu; Yan Shi; Tongxiang Lin; Ergeng Hao; Alberto Hayek; Hongkui Deng; Sheng Ding
Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors.
Cell stem cell 2009;4(1):16-9.
2009: Ramzey Abujarour; Sheng Ding
Induced pluripotent stem cells free of exogenous reprogramming factors.
Genome biology 2009;10(5):220.
2008: Yan Shi; Caroline Desponts; Jeong Tae Do; Heung Sik Hahm; Hans R Schöler; Sheng Ding
Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds.
Cell stem cell 2008;3(5):568-74.
2008: Yue Xu; Yan Shi; Sheng Ding
A chemical approach to stem-cell biology and regenerative medicine.
Nature 2008;453(7193):338-44.
2007: Jongkook Lee; Xu Wu; Marina Pasca di Magliano; Eric C Peters; Yan Wang; Jiyong Hong; Metthias Hebrok; Sheng Ding; Charles Y Cho; Peter G Schultz
A small-molecule antagonist of the hedgehog signaling pathway.
Chembiochem : a European journal of chemical biology 2007;8(16):1916-9.
2007: Rajesh Ambasudhan; Sheng Ding
An "orphan" finds a home in NSC regulation.
Chemistry & biology 2007;14(9):974-5.
2007: Shuibing Chen; Shinichi Takanashi; Qisheng Zhang; Wen Xiong; Shoutian Zhu; Eric C Peters; Sheng Ding; Peter G Schultz
Reversine increases the plasticity of lineage-committed mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(25):10482-7.
2007: Yuanxiang Zhao; Sheng Ding
A high-throughput siRNA library screen identifies osteogenic suppressors in human mesenchymal stem cells.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(23):9673-8.
2007: Nil Emre; Ronald Coleman; Sheng Ding
A chemical approach to stem cell biology.
Current opinion in chemical biology 2007;11(3):252-8.
2007: Qisheng Zhang; Michael Ben Major; Shinichi Takanashi; Nathan D Camp; Naoyuki Nishiya; Eric C Peters; Mark H Ginsberg; Xiaoying Jian; Paul A Randazzo; Peter G Schultz; Randall T Moon; Sheng Ding
Small-molecule synergist of the Wnt/beta-catenin signaling pathway.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(18):7444-8.
2006: Shuibing Chen; Jeong Tae Do; Qisheng Zhang; Shuyuan Yao; Feng Yan; Eric C Peters; Hans R Schöler; Peter G Schultz; Sheng Ding
Self-renewal of embryonic stem cells by a small molecule.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(46):17266-71.
2006: Richard Belvindrah; Perihan Nalbant; Sheng Ding; Chuanyue Wu; Gary M Bokoch; Ulrich Müller
Integrin-linked kinase regulates Bergmann glial differentiation during cerebellar development.
Molecular and cellular neurosciences 2006;33(2):109-25.
2006: Shuyuan Yao; Shuibing Chen; julie clark; Ergeng Hao; Gillian M Beattie; Alberto Hayek; Sheng Ding
Long-term self-renewal and directed differentiation of human embryonic stem cells in chemically defined conditions.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(18):6907-12.
2006: Francisco J Adrián; Qiang Ding; Taebo Sim; Anastasia Velentza; Christine Sloan; Yi Liu; Guobao Zhang; Wooyoung Hur; Sheng Ding; Paul Manley; Jürgen Mestan; Doriano Fabbro; Nathanael S Gray
Allosteric inhibitors of Bcr-abl-dependent cell proliferation.
Nature chemical biology 2006;2(2):95-102.
2006: Masaki Warashina; Kyung Hoon Min; Tomoko Kuwabara; Alexis Huynh; Fred H Gage; Peter G Schultz; Sheng Ding
A synthetic small molecule that induces neuronal differentiation of adult hippocampal neural progenitor cells.
Angewandte Chemie (International ed. in English) 2006;45(4):591-3.
2006: Shuibing Chen; Simon Hilcove; Sheng Ding
Exploring stem cell biology with small molecules.
Molecular bioSystems 2006;2(1):18-24.
2005: Yuanxiang Zhao; julie clark; Sheng Ding
Genomic studies in stem cell systems.
Current opinion in molecular therapeutics 2005;7(6):543-50.
2005: Jun Liu; Xu Wu; Brian Mitchell; Chris Kintner; Sheng Ding; Peter G Schultz
A small-molecule agonist of the Wnt signaling pathway.
Angewandte Chemie (International ed. in English) 2005;44(13):1987-90.
2005: Jun Liu; Anne G Bang; Chris Kintner; Anthony P Orth; Sumit K Chanda; Sheng Ding; Peter G Schultz
Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genome-wide functional analysis.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(6):1927-32.
2005: Sheng Ding; Peter G Schultz
Small molecules and future regenerative medicine.
Current topics in medicinal chemistry 2005;5(4):383-95.
2004: Xu Wu; John Walker; Jie Zhang; Sheng Ding; Peter G Schultz
Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway.
Chemistry & biology 2004;11(9):1229-38.
2004: Sheng Ding; Peter G Schultz
A role for chemistry in stem cell biology.
Nature biotechnology 2004;22(7):833-40.
2004: Lianxing Zheng; Sheng Ding
Mammalian genome-wide loss-of-function screens using arrayed small interfering RNA expression libraries.
Discovery medicine 2004;4(21):102-5.
2004: Xu Wu; Sheng Ding; Qiang Ding; Nathanael S Gray; Peter G Schultz
Small molecules that induce cardiomyogenesis in embryonic stem cells.
Journal of the American Chemical Society 2004;126(6):1590-1.
2004: Shuibing Chen; Qisheng Zhang; Xu Wu; Peter G Schultz; Sheng Ding
Dedifferentiation of lineage-committed cells by a small molecule.
Journal of the American Chemical Society 2004;126(2):410-1.
2004: Tom Y H Wu; Christian Hassig; Yiqin Wu; Sheng Ding; Peter G Schultz
Design, synthesis, and activity of HDAC inhibitors with a N-formyl hydroxylamine head group.
Bioorganic & medicinal chemistry letters 2004;14(2):449-53.
2004: Lianxing Zheng; Jun Liu; Serge Batalov; Demin Zhou; Anthony P Orth; Sheng Ding; Peter G Schultz
An approach to genomewide screens of expressed small interfering RNAs in mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(1):135-40.
2003: Tom Y H Wu; Peter G Schultz; Sheng Ding
One-pot two-step microwave-assisted reaction in constructing 4,5-disubstituted pyrazolopyrimidines.
Organic letters 2003;5(20):3587-90.
2003: Sheng Ding; Tom Y H Wu; Achim Brinker; Eric C Peters; Wooyoung Hur; Nathanael S Gray; Peter G Schultz
Synthetic small molecules that control stem cell fate.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(13):7632-7.
2002: Eli Chapman; Sheng Ding; Peter G Schultz; Chi-Huey Wong
A potent and highly selective sulfotransferase inhibitor.
Journal of the American Chemical Society 2002;124(49):14524-5.
2002: Xu Wu; Sheng Ding; Qiang Ding; Nathanael S Gray; Peter G Schultz
A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells.
Journal of the American Chemical Society 2002;124(49):14520-1.
2002: Young-Tae Chang; Jaehwa Choi; Sheng Ding; Eva E Prieschl; Thomas Baumruker; Jae-Mok Lee; Sung-Kee Chung; Peter G Schultz
The synthesis and biological characterization of a ceramide library.
Journal of the American Chemical Society 2002;124(9):1856-7.
2002: Sheng Ding; Nathanael S Gray; Qiang Ding; Xu Wu; Peter G Schultz
Resin-capture and release strategy toward combinatorial libraries of 2,6,9-substituted purines.
Journal of combinatorial chemistry 2002;4(2):183-6.
2002: Sheng Ding; Nathanael S Gray; Xu Wu; Qiang Ding; Peter G Schultz
A combinatorial scaffold approach toward kinase-directed heterocycle libraries.
Journal of the American Chemical Society 2002;124(8):1594-6.
2001: Sheng Ding; Nathanael S Gray; Qiang Ding; Peter G Schultz
A concise and traceless linker strategy toward combinatorial libraries of 2,6,9-substituted purines.
The Journal of organic chemistry 2001;66(24):8273-6.
2001: Tom Y H Wu; Sheng Ding; Nathanael S Gray; Peter G Schultz
Solid-phase synthesis of 2,3,5-trisubstituted indoles.
Organic letters 2001;3(24):3827-30.