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Marco d'Ischia

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Chemicals & Drugs

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Oxidative Stress

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Giovanni Pagano; Federico V Pallardó; Sandra Petrović; Beatriz Porto; Luca Tiano; Giuseppe Castello; Marco d'Ischia; Annarita Aiello Talamanca; Adriana Zatterale
From clinical description, to in vitro and animal studies, and backward to patients: oxidative stress and mitochondrial dysfunction in Fanconi anemia.
Laura Ascione; Cosimo Carfagna; Veronica Ambrogi; Alessandro Pezzella; Marco d'Ischia
Intermolecular π-electron perturbations generate extrinsic visible contributions to eumelanin black chromophore in model polymers with interrupted interring conjugation.
Lucia Panzella; Sonia Ramos; Luisella Verotta; Laura Bravo; Luis Goya; María Angeles Martín; Alessandra Napolitano; Marco d'Ischia
Synthesis and bioactivity profile of 5-s-lipoylhydroxytyrosol-based multidefense antioxidants with a sizeable (poly)sulfide chain.

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All Publications

2013: Giovanni Pagano; Federico V Pallardó; Sandra Petrović; Beatriz Porto; Luca Tiano; Giuseppe Castello; Marco d'Ischia; Annarita Aiello Talamanca; Adriana Zatterale
From clinical description, to in vitro and animal studies, and backward to patients: oxidative stress and mitochondrial dysfunction in Fanconi anemia.
Free radical biology & medicine 2013;58():118-25.
2013: Laura Ascione; Cosimo Carfagna; Veronica Ambrogi; Alessandro Pezzella; Marco d'Ischia
Intermolecular π-electron perturbations generate extrinsic visible contributions to eumelanin black chromophore in model polymers with interrupted interring conjugation.
Photochemistry and photobiology 2013;89(2):314-8.
2013: Lucia Panzella; Sonia Ramos; Luisella Verotta; Laura Bravo; Luis Goya; María Angeles Martín; Alessandra Napolitano; Marco d'Ischia
Synthesis and bioactivity profile of 5-s-lipoylhydroxytyrosol-based multidefense antioxidants with a sizeable (poly)sulfide chain.
Journal of agricultural and food chemistry 2013;61(8):1710-7.
2013: Alessandra Napolitano; Lucia Panzella; Loredana Leone; Marco d'Ischia
Red hair benzothiazines and benzothiazoles: mutation-inspired chemistry in the quest for functionality.
Accounts of chemical research 2013;46(2):519-28.
2012: Alice Corani; Annemarie Huijser; Alfonso Iadonisi; Alessandro Pezzella; Villy Sundström; Marco d'Ischia
Bottom-up approach to eumelanin photoprotection: emission dynamics in parallel sets of water-soluble 5,6-dihydroxyindole-based model systems.
The journal of physical chemistry. B 2012;116(44):13151-8.
2012: Lucia Panzella; Thomas Eidenberger; Alessandra Napolitano; Marco d'Ischia
Black sesame pigment: DPPH assay-guided purification, antioxidant/antinitrosating properties, and identification of a degradative structural marker.
Journal of agricultural and food chemistry 2012;60(36):8895-901.
2012: Claudia Ciniglia; Alessandra Napolitano; Lucia Panzella; Clementina Sansone; Marco d'Ischia
Effects of walnut husk washing waters and their phenolic constituents on horticultural species.
Environmental science and pollution research international 2012;19(8):3299-306.
2012: Marianna Arzillo; Richard K Heenan; Gaetano Mangiapia; Luigi Paduano; Alessandro Pezzella; Aurel Radulescu; Marco d'Ischia
Eumelanin buildup on the nanoscale: aggregate growth/assembly and visible absorption development in biomimetic 5,6-dihydroxyindole polymerization.
Biomacromolecules 2012;13(8):2379-90.
2012: Elena Ercolesi; Gabriella Fiore; Elisa Maffioli; Armando Negri; Marco d'Ischia; Gabriella Tedeschi; Anna Palumbo
Protein nitration as footprint of oxidative stress-related nitric oxide signaling pathways in developing Ciona intestinalis.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2012;27(1):18-24.
2012: Liliana Lista; Paola Manini; Alessandra Napolitano; Alessandro Pezzella; Marco d'Ischia
Atropodiastereoselectivity in solid state BINOL synthesis: leads from the estradiol platform.
Steroids 2012;77(6):630-4.
2012: Daniela Kovacs; Vittoria Maresca; Alessandra Napolitano; Monica Ottaviani; Lucia Panzella; Mauro Picardo; Nicaela Aspite; Maria Lucia Dell'Anna; Enrica Flori; Marco d'Ischia
The eumelanin intermediate 5,6-dihydroxyindole-2-carboxylic acid is a messenger in the cross-talk among epidermal cells.
The Journal of investigative dermatology 2012;132(4):1196-205.
2012: Samantha Reale; Marcello Crucianelli; Marco d'Ischia; Alessandro Pezzella; Francesco De Angelis
Exploring the frontiers of synthetic eumelanin polymers by high-resolution matrix-assisted laser/desorption ionization mass spectrometry.
Journal of mass spectrometry : JMS 2012;47(1):49-53.
2011: Giorgia Greco; Alessandra Napolitano; Lucia Panzella; Cosimo Carfagna; Maria Emanuela Errico; Gennaro Gentile; Marco d'Ischia
A melanin-inspired pro-oxidant system for dopa(mine) polymerization: mimicking the natural casing process.
Chemical communications (Cambridge, England) 2011;47(37):10308-10.
2011: Luigia Capelli; Orlando Crescenzi; Paola Manini; Alessandro Pezzella; Vincenzo Barone; Marco d'Ischia
π-Electron manipulation of the 5,6-dihydroxyindole/quinone system by 3-alkynylation: mild acid-mediated entry to (cross)-conjugated scaffolds and paradigms for medium-tunable chromophores.
The Journal of organic chemistry 2011;76(11):4457-66.
2011: Giorgia Greco; Lucia Panzella; Luisella Verotta; Marco d'Ischia; Alessandra Napolitano
Uncovering the structure of human red hair pheomelanin: benzothiazolylthiazinodihydroisoquinolines as key building blocks.
Journal of natural products 2011;74(4):675-82.
2011: Wiete Westerhof; Paola Manini; Alessandra Napolitano; Marco d'Ischia
The haptenation theory of vitiligo and melanoma rejection: a close-up.
Experimental dermatology 2011;20(2):92-6.
2011: Lucia Panzella; Alessandra Napolitano; Marco d'Ischia
Is DHICA the key to dopachrome tautomerase and melanocyte functions?
Pigment cell & melanoma research 2011;24(1):248-9.
2011: Eliana Guerriero; Pasquale Palladino; Angela Sorice; Francesca Capone; Susan Costantini; Marco d'Ischia; Giuseppe Castello
Effects of lipoic acid, caffeic acid and a synthesized lipoyl-caffeic conjugate on human hepatoma cell lines.
Molecules (Basel, Switzerland) 2011;16(8):6365-77.
2011: Alessandra Napolitano; Paola Manini; Marco d'Ischia
Oxidation chemistry of catecholamines and neuronal degeneration: an update.
Current medicinal chemistry 2011;18(12):1832-45.
2010: Luigia Capelli; Paola Manini; Alessandro Pezzella; Marco d'Ischia
First synthetic entry to the trimer stage of 5,6-dihydroxyindole polymerization: ortho-alkynylaniline-based access to the missing 2,7':2',7''-triindole.
Organic & biomolecular chemistry 2010;8(19):4243-5.
2010: Annemarie Huijser; Alessandro Pezzella; Jonas K Hannestad; Lucia Panzella; Alessandra Napolitano; Marco d'Ischia; Villy Sundström
UV-dissipation mechanisms in the eumelanin building block DHICA.
Chemphyschem : a European journal of chemical physics and physical chemistry 2010;11(11):2424-31.
2010: Federico V Pallardó; Ana Lloret; Michel Lebel; Marco d'Ischia; Victoria C Cogger; David G Le Couteur; Maria Nicola Gadaleta; Giuseppe Castello; Giovanni Pagano
Mitochondrial dysfunction in some oxidative stress-related genetic diseases: Ataxia-Telangiectasia, Down Syndrome, Fanconi Anaemia and Werner Syndrome.
Biogerontology 2010;11(4):401-19.
2010: Teresa Mattiello; Gabriella Fiore; Euan R Brown; Marco d'Ischia; Anna Palumbo
Nitric oxide mediates the glutamate-dependent pathway for neurotransmission in Sepia officinalis chromatophore organs.
The Journal of biological chemistry 2010;285(31):24154-63.
2010: Marianna Arzillo; Alessandro Pezzella; Orlando Crescenzi; Alessandra Napolitano; Edward J Land; Vincenzo Barone; Marco d'Ischia
Cyclic structural motifs in 5,6-dihydroxyindole polymerization uncovered: biomimetic modular buildup of a unique five-membered macrocycle.
Organic letters 2010;12(14):3250-3.
2010: Lucia Panzella; Grzegorz Szewczyk; Marco d'Ischia; Alessandra Napolitano; Tadeusz Sarna
Zinc-induced structural effects enhance oxygen consumption and superoxide generation in synthetic pheomelanins on UVA/visible light irradiation.
Photochemistry and photobiology 2010;86(4):757-64.
2010: Alessandro Pezzella; Veronica Ambrogi; Marianna Arzillo; Alessandra Napolitano; Cosimo Carfagna; Marco d'Ischia
5,6-Dihydroxyindole oxidation in phosphate buffer/polyvinyl alcohol: a new model system for studies of visible chromophore development in synthetic eumelanin polymers.
Photochemistry and photobiology 2010;86(3):533-7.
2010: Carlo Di Cristo; Paola Di Donato; Anna Palumbo; Marco d'Ischia; Marina Paolucci; Anna Di Cosmo
Steroidogenesis in the brain of Sepia officinalis and Octopus vulgaris.
Frontiers in bioscience (Elite edition) 2010;2():673-83.
2009: Maria De Lucia; Lucia Panzella; Dominique Melck; Italo Giudicianni; Andrea Motta; Alessandra Napolitano; Marco d'Ischia
Differential reactivity of purified bioactive coffee furans, cafestol and kahweol, with acidic nitrite: product characterization and factors controlling nitrosation versus ring-opening pathways.
Chemical research in toxicology 2009;22(12):1922-8.
2009: Gabriella Fiore; Teresa Mattiello; Gabriella Tedeschi; Simona Nonnis; Marco d'Ischia; Anna Palumbo
Protein nitration is specifically associated with melanin production and reveals redox imbalance as a new correlate of cell maturation in the ink gland of Sepia officinalis.
Pigment cell & melanoma research 2009;22(6):857-9.
2009: Alessandro Pezzella; Alfonso Iadonisi; Silvia Valerio; Lucia Panzella; Alessandra Napolitano; Matteo Adinolfi; Marco d'Ischia
Disentangling eumelanin "black chromophore": visible absorption changes as signatures of oxidation state- and aggregation-dependent dynamic interactions in a model water-soluble 5,6-dihydroxyindole polymer.
Journal of the American Chemical Society 2009;131(42):15270-5.
2009: Luigia Capelli; Paola Manini; Alessandro Pezzella; Alessandra Napolitano; Marco d'Ischia
Efficient synthesis of 5,6-dihydroxyindole dimers, key eumelanin building blocks, by a unified o-ethynylaniline-based strategy for the construction of 2-linked biindolyl scaffolds.
The Journal of organic chemistry 2009;74(18):7191-4.
2009: Magdalena Gauden; Alessandro Pezzella; Lucia Panzella; Alessandra Napolitano; Marco d'Ischia; Villy Sundström
Ultrafast excited state dynamics of 5,6-dihydroxyindole, a key eumelanin building block: nonradiative decay mechanism.
The journal of physical chemistry. B 2009;113(37):12575-80.
2009: Antonio Toffoletti; Fosca Conti; Tommaso Sandron; Alessandra Napolitano; Lucia Panzella; Marco d'Ischia
Time-resolved EPR observation of synthetic eumelanin-superoxide radical pairs.
Chemical communications (Cambridge, England) 2009;(33):4977-9.
2009: Paola Manini; Alessandra Napolitano; Wiete Westerhof; Patrick A Riley; Marco d'Ischia
A reactive ortho-quinone generated by tyrosinase-catalyzed oxidation of the skin depigmenting agent monobenzone: self-coupling and thiol-conjugation reactions and possible implications for melanocyte toxicity.
Chemical research in toxicology 2009;22(8):1398-405.
2009: Giorgia Greco; Kazumasa Wakamatsu; Lucia Panzella; Shosuke Ito; Alessandra Napolitano; Marco d'Ischia
Isomeric cysteinyldopas provide a (photo)degradable bulk component and a robust structural element in red human hair pheomelanin.
Pigment cell & melanoma research 2009;22(3):319-27.
2009: Alessandro Pezzella; Lucia Panzella; Orlando Crescenzi; Alessandra Napolitano; Suppiah Navaratnam; Ruth Edge; Edward J Land; Vincenzo Barone; Marco d'Ischia
Lack of visible chromophore development in the pulse radiolysis oxidation of 5,6-dihydroxyindole-2-carboxylic acid oligomers: DFT investigation and implications for eumelanin absorption properties.
The Journal of organic chemistry 2009;74(10):3727-34.
2009: Marco d'Ischia; Alessandra Napolitano; Alessandro Pezzella; Paul Meredith; Tadeusz Sarna
Chemical and structural diversity in eumelanins: unexplored bio-optoelectronic materials.
Angewandte Chemie (International ed. in English) 2009;48(22):3914-21.
2008: Maria De Lucia; Lucia Panzella; Alessandro Pezzella; Alessandra Napolitano; Marco d'Ischia
Plant catechols and their S-glutathionyl conjugates as antinitrosating agents: expedient synthesis and remarkable potency of 5-S-glutathionylpiceatannol.
Chemical research in toxicology 2008;21(12):2407-13.
2008: Paola Manini; Luigia Capelli; Samantha Reale; Marianna Arzillo; Orlando Crescenzi; Alessandra Napolitano; Vincenzo Barone; Marco d'Ischia
Chemistry of nitrated lipids: remarkable instability of 9-nitrolinoleic acid in neutral aqueous medium and a novel nitronitrate ester product by concurrent autoxidation/nitric oxide-release pathways.
The Journal of organic chemistry 2008;73(19):7517-25.
2008: Bruce Freeman; Paul Baker; Francisco J Schopfer; Steven R Woodcock; Alessandra Napolitano; Marco d'Ischia
Nitro-fatty acid formation and signaling.
The Journal of biological chemistry 2008;283(23):15515-9.
2008: Marco d'Ischia; Orlando Crescenzi; Alessandro Pezzella; Marianna Arzillo; Lucia Panzella; Alessandra Napolitano; Vincenzo Barone
Structural effects on the electronic absorption properties of 5,6-dihydroxyindole oligomers: the potential of an integrated experimental and DFT approach to model eumelanin optical properties.
Photochemistry and photobiology 2008;84(3):600-7.
2008: Alessandra Napolitano; Maria De Lucia; Lucia Panzella; Marco d'Ischia
The "benzothiazine" chromophore of pheomelanins: a reassessment.
Photochemistry and photobiology 2008;84(3):593-9.
2008: Ana Lloret; Rita Calzone; Christina Dunster; Paola Manini; Marco d'Ischia; Paolo Degan; Frank Kelly; Federico V Pallardó; Adriana Zatterale; Giovanni Pagano
Different patterns of in vivo pro-oxidant states in a set of cancer- or aging-related genetic diseases.
Free radical biology & medicine 2008;44(4):495-503.
2008: Paola Manini; Emanuela Camera; Mauro Picardo; Alessandra Napolitano; Marco d'Ischia
Biomimetic nitration of the linoleic acid metabolite 13-hydroxyoctadecadienoic acid: isolation and spectral characterization of novel chain-rearranged epoxy nitro derivatives.
Chemistry and physics of lipids 2008;151(1):51-61.
2008: Valeria Russo; Giuseppe Borzacchiello; R Brun; Marco d'Ischia; Alessandra Napolitano; Orlando Paciello; Lucia Panzella; Franco Roperto; C Urraro; Sante Roperto
Melanosis of the urinary bladder in a cow.
Veterinary pathology 2008;45(1):46-50.
2007: Maria De Lucia; Francesco Mainieri; Luisella Verotta; Massimo Maffei; Lucia Panzella; Orlando Crescenzi; Alessandra Napolitano; Vincenzo Barone; Giovanni Appendino; Marco d'Ischia
Nitration versus nitrosation chemistry of menthofuran: remarkable fragmentation and dimerization pathways and expeditious entry into dehydromenthofurolactone.
The Journal of organic chemistry 2007;72(26):10123-9.
2007: Alessandro Pezzella; Lucia Panzella; Anna Natangelo; Marianna Arzillo; Alessandra Napolitano; Marco d'Ischia
5,6-dihydroxyindole tetramers with "anomalous" interunit bonding patterns by oxidative coupling of 5,5',6,6'-tetrahydroxy-2,7'-biindolyl: emerging complexities on the way toward an improved model of eumelanin buildup.
The Journal of organic chemistry 2007;72(24):9225-30.
2007: Paola Manini; Lucia Panzella; Alessandra Napolitano; Marco d'Ischia
Oxidation chemistry of norepinephrine: partitioning of the O-quinone between competing cyclization and chain breakdown pathways and their roles in melanin formation.
Chemical research in toxicology 2007;20(10):1549-55.
2007: Wiete Westerhof; Marco d'Ischia
Vitiligo puzzle: the pieces fall in place.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2007;20(5):345-59.
2007: Adriana Zatterale; Frank Kelly; Paolo Degan; Marco d'Ischia; Federico V Pallardó; Rita Calzone; Christina Dunster; Ana Lloret; Paola Manini; Ozgur Coğulu; Kaan Kavakli; Giovanni Pagano
Oxidative stress biomarkers in four Bloom syndrome (BS) patients and in their parents suggest in vivo redox abnormalities in BS phenotype.
Clinical biochemistry 2007;40(15):1100-3.
2007: Carlo Di Cristo; Gabriella Fiore; Vladimir Scheinker; Grigori Enikolopov; Marco d'Ischia; Anna Palumbo; Anna Di Cosmo
Nitric oxide synthase expression in the central nervous system of Sepia officinalis: an in situ hybridization study.
The European journal of neuroscience 2007;26(6):1599-610.
2007: Stefania Comes; Annamaria Locascio; Francesco Silvestre; Marco d'Ischia; Gian Luigi Russo; Elisabetta Tosti; Margherita Branno; Anna Palumbo
Regulatory roles of nitric oxide during larval development and metamorphosis in Ciona intestinalis.
Developmental biology 2007;306(2):772-84.
2007: Paolo Degan; Marco d'Ischia; Federico V Pallardó; Adriana Zatterale; Alfredo Brusco; Rita Calzone; Simona Cavalieri; Kaan Kavakli; Ana Lloret; Paola Manini; Maria Antonietta Pisanti; Emilia Vuttariello; Giovanni Pagano
Glutathione levels in blood from ataxia telangiectasia patients suggest in vivo adaptive mechanisms to oxidative stress.
Clinical biochemistry 2007;40(9-10):666-70.
2007: Lucia Panzella; Paola Manini; Giuseppe Monfrecola; Marco d'Ischia; Alessandra Napolitano
An easy-to-run method for routine analysis of eumelanin and pheomelanin in pigmented tissues.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2007;20(2):128-33.
2007: Lucia Panzella; Alessandro Pezzella; Alessandra Napolitano; Marco d'Ischia
The first 5,6-dihydroxyindole tetramer by oxidation of 5,5',6,6'-tetrahydroxy- 2,4'-biindolyl and an unexpected issue of positional reactivity en route to eumelanin-related polymers.
Organic letters 2007;9(7):1411-4.
2007: Alessandro Pezzella; Orlando Crescenzi; Anna Natangelo; Lucia Panzella; Alessandra Napolitano; Suppiah Navaratnam; Ruth Edge; Edward J Land; Vincenzo Barone; Marco d'Ischia
Chemical, pulse radiolysis and density functional studies of a new, labile 5,6-indolequinone and its semiquinone.
The Journal of organic chemistry 2007;72(5):1595-603.
2007: Angela Amoresano; Giovanni Chiappetta; Piero Pucci; Marco d'Ischia; Gennaro Marino
Bidimensional tandem mass spectrometry for selective identification of nitration sites in proteins.
Analytical chemistry 2007;79(5):2109-17.
2006: Alessandro Pezzella; Lucia Panzella; Orlando Crescenzi; Alessandra Napolitano; Suppiah Navaratman; Ruth Edge; Edward J Land; Vincenzo Barone; Marco d'Ischia
Short-lived quinonoid species from 5,6-dihydroxyindole dimers en route to eumelanin polymers: integrated chemical, pulse radiolytic, and quantum mechanical investigation.
Journal of the American Chemical Society 2006;128(48):15490-8.
2006: Ruth Edge; Marco d'Ischia; Edward J Land; Alessandra Napolitano; Suppiah Navaratnam; Lucia Panzella; Alessandro Pezzella; Christopher A Ramsden; Patrick A Riley
Dopaquinone redox exchange with dihydroxyindole and dihydroxyindole carboxylic acid.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2006;19(5):443-50.
2006: Paola Manini; Paola La Pietra; Lucia Panzella; Alessandra Napolitano; Marco d'Ischia
Glyoxal formation by Fenton-induced degradation of carbohydrates and related compounds.
Carbohydrate research 2006;341(11):1828-33.
2006: Liliana Lista; Paola Manini; Alessandra Napolitano; Alessandro Pezzella; Marco d'Ischia
Practical one-pot conversion of 17beta-estradiol to 10beta-hydroxy- (p-quinol) and 10beta-chloro-17beta-hydroxyestra-1,4-dien-3-one.
Steroids 2006;71(8):670-3.
2006: Federico V Pallardó; Paolo Degan; Marco d'Ischia; Frank Kelly; Adriana Zatterale; Rita Calzone; Giuseppe Castello; Rafael Fernandez-Delgado; Christina Dunster; Ana Lloret; Paola Manini; Maria Antonietta Pisanti; Emilia Vuttariello; Giovanni Pagano
Multiple evidence for an early age pro-oxidant state in Down Syndrome patients.
Biogerontology 2006;7(4):211-20.
2006: Paola Manini; Stefania Briganti; C Fabbri; Mauro Picardo; Alessandra Napolitano; Marco d'Ischia
Free radical oxidation of 15-(S)-hydroxyeicosatetraenoic acid with the Fenton reagent: characterization of an epoxy-alcohol and cytotoxic 4-hydroxy-2E-nonenal from the heptatrienyl radical pathway.
Chemistry and physics of lipids 2006;142(1-2):14-22.
2006: Lucia Panzella; Maria De Lucia; Carmine Amalfitano; Alessandro Pezzella; Antonio Evidente; Alessandra Napolitano; Marco d'Ischia
Acid-promoted reaction of the stilbene antioxidant resveratrol with nitrite ions: mild phenolic oxidation at the 4'-hydroxystiryl sector triggering nitration, dimerization, and aldehyde-forming routes.
The Journal of organic chemistry 2006;71(11):4246-54.
2006: Maria De Lucia; Lucia Panzella; Orlando Crescenzi; Alessandra Napolitano; Vincenzo Barone; Marco d'Ischia
The catecholic antioxidant piceatannol is an effective nitrosation inhibitor via an unusual double bond nitration.
Bioorganic & medicinal chemistry letters 2006;16(8):2238-42.
2006: Gabriella Fiore; Carlo Di Cristo; Gianluca Monti; Angela Amoresano; Laura Columbano; Piero Pucci; Fernando A Cioffi; Anna Di Cosmo; Anna Palumbo; Marco d'Ischia
Tubulin nitration in human gliomas.
Neuroscience letters 2006;394(1):57-62.
2006: Marco d'Ischia; Lucia Panzella; Paola Manini; Alessandra Napolitano
The chemical basis of the antinitrosating action of polyphenolic cancer chemopreventive agents.
Current medicinal chemistry 2006;13(26):3133-44.
2005: Paola Manini; Alessandra Napolitano; Marco d'Ischia
Reactions of D-glucose with phenolic amino acids: further insights into the competition between Maillard and Pictet-Spengler condensation pathways.
Carbohydrate research 2005;340(18):2719-27.
2005: Vladimir Scheinker; Gabriella Fiore; Carlo Di Cristo; Anna Di Cosmo; Marco d'Ischia; Grigori Enikolopov; Anna Palumbo
Nitric oxide synthase in the nervous system and ink gland of the cuttlefish Sepia officinalis: molecular cloning and expression.
Biochemical and biophysical research communications 2005;338(2):1204-15.
2005: Alessandro Pezzella; Liliana Lista; Alessandra Napolitano; Marco d'Ischia
Tyrosinase-catalyzed oxidation of 17beta-estradiol: structure elucidation of the products formed beyond catechol estrogen quinones.
Chemical research in toxicology 2005;18(9):1413-9.
2005: Giovanni Pagano; Paolo Degan; Marco d'Ischia; Frank Kelly; Bruno Nobili; Federico V Pallardó; Hagop Youssoufian; Adriana Zatterale
Oxidative stress as a multiple effector in Fanconi anaemia clinical phenotype.
European journal of haematology 2005;75(2):93-100.
2005: Alessandro Pezzella; Paola Manini; Alessandra Napolitano; Orlando Crescenzi; Vincenzo Barone; Marco d'Ischia
Oxidative chemistry of 2-nitro and 4-nitroestradiol: Dichotomous behavior of radical intermediates and novel potential routes for oxyfunctionalization and B-ring fission of steroidal scaffolds.
Steroids 2005;70(8):543-50.
2005: Giovanni Pagano; Adriana Zatterale; Paolo Degan; Marco d'Ischia; Frank Kelly; Federico V Pallardó; Rita Calzone; Giuseppe Castello; Christina Dunster; Aldo Giudice; Yurdanur Kilinç; Ana Lloret; Paola Manini; Roberta Masella; Emilia Vuttariello; Michel Warnau
In vivo prooxidant state in Werner syndrome (WS): results from three WS patients and two WS heterozygotes.
Free radical research 2005;39(5):529-33.
2005: Lucia Panzella; Paola Manini; Alessandra Napolitano; Marco d'Ischia
The acid-promoted reaction of the green tea polyphenol epigallocatechin gallate with nitrite ions.
Chemical research in toxicology 2005;18(4):722-9.
2005: Paola Manini; Emanuela Camera; Mauro Picardo; Alessandra Napolitano; Marco d'Ischia
Free radical oxidation of coriolic acid (13-(S)-hydroxy-9Z,11E-octadecadienoic acid).
Chemistry and physics of lipids 2005;134(2):161-71.
2005: Giovanni Pagano; Adriana Zatterale; Paolo Degan; Marco d'Ischia; Frank Kelly; Federico V Pallardó; Seiji Kodama
Multiple involvement of oxidative stress in Werner syndrome phenotype.
Biogerontology 2005;6(4):233-43.
2004: Lucia Panzella; Paola Manini; Alessandra Napolitano; Marco d'Ischia
Free radical oxidation of (E)-retinoic acid by the Fenton reagent: competing epoxidation and oxidative breakdown pathways and novel products of 5,6-epoxyretinoic acid transformation.
Chemical research in toxicology 2004;17(12):1716-24.
2004: Alessandra Napolitano; Lucia Panzella; Maria Flavia Savarese; Raffaele Sacchi; Italo Giudicianni; Livio Paolillo; Marco d'Ischia
Acid-induced structural modifications of unsaturated Fatty acids and phenolic olive oil constituents by nitrite ions: a chemical assessment.
Chemical research in toxicology 2004;17(10):1329-37.
2004: Giovanni Pagano; Paolo Degan; Marco d'Ischia; Frank Kelly; Federico V Pallardó; Adriana Zatterale; S Sema Anak; Ebru E Akisik; Gerardo Beneduce; Rita Calzone; Elena De Nicola; Christina Dunster; Ana Lloret; Paola Manini; Bruno Nobili; Anna Saviano; Emilia Vuttariello; Michel Warnau
Gender- and age-related distinctions for the in vivo prooxidant state in Fanconi anaemia patients.
Carcinogenesis 2004;25(10):1899-909.
2004: Paola Manini; Lucia Panzella; Idolo Tedesco; Fabio Petitto; Gian Luigi Russo; Alessandra Napolitano; Anna Palumbo; Marco d'Ischia
Tetrahydrobiisoquinoline derivatives by reaction of dopamine with glyoxal: a novel potential degenerative pathway of catecholamines under oxidative stress conditions.
Chemical research in toxicology 2004;17(9):1190-8.
2004: Alessandro Pezzella; Liliana Lista; Alessandra Napolitano; Marco d'Ischia
Oxidative coupling of 17beta-estradiol: inventory of oligomer products and configuration assignment of atropoisomeric c4-linked biphenyl-type dimers and trimers.
The Journal of organic chemistry 2004;69(17):5652-9.
2004: Alessandro Pezzella; Paola Manini; Paola Di Donato; Raffaele Boni; Alessandra Napolitano; Anna Palumbo; Marco d'Ischia
17beta-Estradiol nitration by peroxidase/H2O2/NO2-: a chemical assessment.
Bioorganic & medicinal chemistry 2004;12(11):2927-36.
2004: Gabriella Fiore; Annarita Poli; Anna Di Cosmo; Marco d'Ischia; Anna Palumbo
Dopamine in the ink defence system of Sepia officinalis: biosynthesis, vesicular compartmentation in mature ink gland cells, nitric oxide (NO)/cGMP-induced depletion and fate in secreted ink.
The Biochemical journal 2004;378(Pt 3):785-91.
2004: Davide Vogna; Raffaele Marotta; Alessandra Napolitano; Roberto Andreozzi; Marco d'Ischia
Advanced oxidation of the pharmaceutical drug diclofenac with UV/H2O2 and ozone.
Water research 2004;38(2):414-22.
2004: Davide Vogna; Raffaele Marotta; Roberto Andreozzi; Alessandra Napolitano; Marco d'Ischia
Kinetic and chemical assessment of the UV/H2O2 treatment of antiepileptic drug carbamazepine.
Chemosphere 2004;54(4):497-505.
2003: Lucia Panzella; Alessandra Napolitano; Marco d'Ischia
Oxidative conjugation of chlorogenic acid with glutathione. Structural characterization of addition products and a new nitrite-Promoted pathway.
Bioorganic & medicinal chemistry 2003;11(22):4797-805.
2003: Maria Lucia Dell'Anna; Sandra Urbanelli; Arianna Mastrofrancesco; Emanuela Camera; Paolo Iacovelli; Giovanni Leone; Paola Manini; Marco d'Ischia; Mauro Picardo
Alterations of mitochondria in peripheral blood mononuclear cells of vitiligo patients.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2003;16(5):553-9.
2003: Gian Luigi Russo; Elio De Nisco; Gabriella Fiore; Paola Di Donato; Marco d'Ischia; Anna Palumbo
Toxicity of melanin-free ink of Sepia officinalis to transformed cell lines: identification of the active factor as tyrosinase.
Biochemical and biophysical research communications 2003;308(2):293-9.
2003: Paola Manini; Alessandra Napolitano; Emanuela Camera; Teresa Caserta; Mauro Picardo; Anna Palumbo; Marco d'Ischia
Ni2+ enhances Fe2+/peroxide-induced oxidation of arachidonic acid and formation of geno/cytotoxic 4-hydroxynonenal: a possible contributory mechanism in nickel toxicity and allergenicity.
Biochimica et biophysica acta 2003;1621(1):9-16.
2003: Lucia Panzella; Paola Manini; Orlando Crescenzi; Alessandra Napolitano; Marco d'Ischia
Nitrite-induced nitration pathways of retinoic acid, 5,6-epoxyretinoic acid, and their esters under mildly acidic conditions: toward a reappraisal of retinoids as scavengers of reactive nitrogen species.
Chemical research in toxicology 2003;16(4):502-11.
2002: Lucia Panzella; Alessandra Napolitano; Marco d'Ischia
Nitrite-mediated decarboxylative conjugation of caffeic acid with glutathione under mildly acidic conditions.
Bioorganic & medicinal chemistry letters 2002;12(24):3547-50.
2002: Davide Vogna; Raffaele Marotta; Alessandra Napolitano; Marco d'Ischia
Advanced oxidation chemistry of paracetamol. UV/H(2)O(2)-induced hydroxylation/degradation pathways and (15)N-aided inventory of nitrogenous breakdown products.
The Journal of organic chemistry 2002;67(17):6143-51.
2002: Anna Palumbo; Gabriella Fiore; Carlo Di Cristo; Anna Di Cosmo; Marco d'Ischia
NMDA receptor stimulation induces temporary alpha-tubulin degradation signaled by nitric oxide-mediated tyrosine nitration in the nervous system of Sepia officinalis.
Biochemical and biophysical research communications 2002;293(5):1536-43.
2002: Alessandra Napolitano; Marco d'Ischia
New insights into the acid-promoted reaction of caffeic acid and its esters with nitrite: decarboxylation drives chain nitrosation pathways toward novel oxime derivatives and oxidation/fragmentation products thereof.
The Journal of organic chemistry 2002;67(3):803-10.
2002: Anna Palumbo; Alessandra Napolitano; Marco d'Ischia
Nitrocatechols versus nitrocatecholamines as novel competitive inhibitors of neuronal nitric oxide synthase: lack of the aminoethyl side chain determines loss of tetrahydrobiopterin-antagonizing properties.
Bioorganic & medicinal chemistry letters 2002;12(1):13-6.
2001: Anna Palumbo; Alessandra Napolitano; Antonio Carraturo; Gian Luigi Russo; Marco d'Ischia
Oxidative conversion of 6-nitrocatecholamines to nitrosating products: a possible contributory factor in nitric oxide and catecholamine neurotoxicity associated with oxidative stress and acidosis.
Chemical research in toxicology 2001;14(9):1296-305.
2001: Paola Manini; Marco d'Ischia; Giuseppe Prota
An unusual decarboxylative Maillard reaction between L-DOPA and D-glucose under biomimetic conditions: factors governing competition with Pictet-Spengler condensation.
The Journal of organic chemistry 2001;66(15):5048-53.
2000: Anna Di Cosmo; Carlo Di Cristo; Anna Palumbo; Marco d'Ischia; J B Messenger
Nitric oxide synthase (NOS) in the brain of the cephalopod Sepia officinalis.
The Journal of comparative neurology 2000;428(3):411-27.
2000: Anna Palumbo; Marco d'Ischia; Fernando A Cioffi
2-thiouracil is a selective inhibitor of neuronal nitric oxide synthase antagonising tetrahydrobiopterin-dependent enzyme activation and dimerisation.
FEBS letters 2000;485(2-3):109-12.
2000: Alessandra Napolitano; Emanuela Camera; Mauro Picardo; Marco d'Ischia
Acid-promoted reactions of ethyl linoleate with nitrite ions: formation and structural characterization of isomeric nitroalkene, nitrohydroxy, and novel 3-nitro-1,5-hexadiene and 1,5-dinitro-1, 3-pentadiene products.
The Journal of organic chemistry 2000;65(16):4853-60.
2000: Paola Manini; Marco d'Ischia; Giuseppe Prota
A novel octahydropyridobenzothiazepine metabolite in human urine: biomimetic formation from the melanogen 5-S-cysteinyldopa and formaldehyde via a peculiar sulfur-controlled double Pictet-Spengler condensation.
The Journal of organic chemistry 2000;65(14):4269-73.
2000: Anna Palumbo; Annarita Poli; Anna Di Cosmo; Marco d'Ischia
N-Methyl-D-aspartate receptor stimulation activates tyrosinase and promotes melanin synthesis in the ink gland of the cuttlefish Sepia officinalis through the nitric Oxide/cGMP signal transduction pathway. A novel possible role for glutamate as physiologic activator of melanogenesis.
The Journal of biological chemistry 2000;275(22):16885-90.
2000: Marco d'Ischia; Anna Palumbo; F Buzzo
Interactions of nitric oxide with lipid peroxidation products under aerobic conditions: inhibitory effects on the formation of malondialdehyde and related thiobarbituric acid-reactive substances.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2000;4(1):4-14.
1999: Anna Palumbo; Alessandra Napolitano; P Barone; Marco d'Ischia
Nitrite- and peroxide-dependent oxidation pathways of dopamine: 6-nitrodopamine and 6-hydroxydopamine formation as potential contributory mechanisms of oxidative stress- and nitric oxide-induced neurotoxicity in neuronal degeneration.
Chemical research in toxicology 1999;12(12):1213-22.
1999: Paola Manini; Marco d'Ischia; R Lanzetta; M Parrilli; Giuseppe Prota
Reaction of dopamine with D-glyceraldehyde under biomimetic conditions: stereoselective formation of tetrahydroisoquinolines and rate-accelerating effects of transition metal ions.
Bioorganic & medicinal chemistry 1999;7(11):2525-30.
1999: Anna Palumbo; Anna Di Cosmo; Annarita Poli; Carlo Di Cristo; Marco d'Ischia
A calcium/calmodulin-dependent nitric oxide synthase, NMDAR2/3 receptor subunits, and glutamate in the CNS of the cuttlefish Sepia officinalis: localization in specific neural pathways controlling the inking system.
Journal of neurochemistry 1999;73(3):1254-63.
1998: Luisa Novellino; Marco d'Ischia; Giuseppe Prota
Nitric oxide-induced oxidation of 5,6-dihydroxyindole and 5,6-dihydroxyindole-2-carboxylic acid under aerobic conditions: non-enzymatic route to melanin pigments of potential relevance to skin (photo)protection.
Biochimica et biophysica acta 1998;1425(1):27-35.
1998: MR Vincensi; Marco d'Ischia; Alessandra Napolitano; Enrico Maria Procaccini; Giuseppe Riccio; Giuseppe Monfrecola; Pietro Santoianni; Giuseppe Prota
Phaeomelanin versus eumelanin as a chemical indicator of ultraviolet sensitivity in fair-skinned subjects at high risk for melanoma: a pilot study.
Melanoma research 1998;8(1):53-8.
1997: Anna Palumbo; U Mårs; L De Martino; Marco d'Ischia; Alessandra Napolitano; BS Larsson; Giuseppe Prota
Selective incorporation of the prototype melanoma seeker thiourea into nascent melanin: a chemical insight.
Melanoma research 1997;7(6):478-85.
1997: Marco d'Ischia; Giuseppe Prota
Biosynthesis, structure, and function of neuromelanin and its relation to Parkinson's disease: a critical update.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 1997;10(6):370-6.
1997: Alessandro Pezzella; Marco d'Ischia; Alessandra Napolitano; G Misuraca; Giuseppe Prota
Iron-mediated generation of the neurotoxin 6-hydroxydopamine quinone by reaction of fatty acid hydroperoxides with dopamine: a possible contributory mechanism for neuronal degeneration in Parkinson's disease.
Journal of medicinal chemistry 1997;40(14):2211-6.
1997: Anna Palumbo; Anna Di Cosmo; I Gesualdo; Marco d'Ischia
A calcium-dependent nitric oxide synthase and NMDA R1 glutamate receptor in the ink gland of Sepia officinalis: a hint to a regulatory role of nitric oxide in melanogenesis?
Biochemical and biophysical research communications 1997;235(2):429-32.
1997: S Memoli; Alessandra Napolitano; Marco d'Ischia; G Misuraca; Anna Palumbo; Giuseppe Prota
Diffusible melanin-related metabolites are potent inhibitors of lipid peroxidation.
Biochimica et biophysica acta 1997;1346(1):61-8.
1996: Alessandra Napolitano; Anna Palumbo; Marco d'Ischia; Giuseppe Prota
Mechanism of selective incorporation of the melanoma seeker 2-thiouracil into growing melanin.
Journal of medicinal chemistry 1996;39(26):5192-201.
1996: Marco d'Ischia; Luisa Novellino
Nitric oxide-induced oxidation of alpha-tocopherol.
Bioorganic & medicinal chemistry 1996;4(10):1747-53.
1996: Alessandra Napolitano; S Memoli; Anthony J Nappi; Marco d'Ischia; Giuseppe Prota
5-S-cysteinyldopa, a diffusible product of melanocyte activity, is an efficient inhibitor of hydroxylation/oxidation reactions induced by the Fenton system.
Biochimica et biophysica acta 1996;1291(1):75-82.
1996: Marco d'Ischia; C Costantini; Giuseppe Prota
Lipofuscin-like pigments by autoxidation of polyunsaturated fatty acids in the presence of amine neurotransmitters: the role of malondialdehyde.
Biochimica et biophysica acta 1996;1290(3):319-26.
1995: Fulvio D'Acquisto; Rosa Carnuccio; Marco d'Ischia; G Misuraca
5,6-Dihydroxyindole-2-carboxylic acid, a diffusible melanin precursor, is a potent stimulator of lipopolysaccharide-induced production of nitric oxide by J774 macrophages.
Life sciences 1995;57(26):PL401-6.
1995: Anna Palumbo; Marco d'Ischia; G Misuraca; L De Martino; Giuseppe Prota
Iron- and peroxide-dependent conjugation of dopamine with cysteine: oxidative routes to the novel brain metabolite 5-S-cysteinyldopamine.
Biochimica et biophysica acta 1995;1245(2):255-61.
1995: Marco d'Ischia; C Costantini
Nitric oxide-induced nitration of catecholamine neurotransmitters: a key to neuronal degeneration?
Bioorganic & medicinal chemistry 1995;3(7):923-7.
1994: Giuseppe Prota; Marco d'Ischia; D Mascagna
Melanogenesis as a targeting strategy against metastatic melanoma: a reassessment.
Melanoma research 1994;4(6):351-8.
1994: C Costantini; Marco d'Ischia; Anna Palumbo; Giuseppe Prota
Photochemistry of 5-S-cysteinyldopa.
Photochemistry and photobiology 1994;60(1):33-7.
1994: Anna Palumbo; Marco d'Ischia; G Misuraca; L De Martino; Giuseppe Prota
A new dopachrome-rearranging enzyme from the ejected ink of the cuttlefish Sepia officinalis.
The Biochemical journal 1994;299 ( Pt 3)():839-44.
1993: Giuseppe Prota; Marco d'Ischia
Neuromelanin: a key to Parkinson's disease.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 1993;6(5):333-5.
1992: K Tsukamoto; Anna Palumbo; Marco d'Ischia; Vincent J Hearing; Giuseppe Prota
5,6-Dihydroxyindole-2-carboxylic acid is incorporated in mammalian melanin.
The Biochemical journal 1992;286 ( Pt 2)():491-5.
1992: C Costantini; Marco d'Ischia; Alessandra Napolitano; G Misuraca; Giuseppe Prota
Photodynamic degradation of vitamin E induced by psoralens.
Biochimica et biophysica acta 1992;1116(3):291-6.
1992: D Mascagna; Ghanem Ghanem; Renato Morandini; Marco d'Ischia; G Misuraca; F Lejeune; Giuseppe Prota
Synthesis and cytotoxic properties of new N-substituted 4-aminophenol derivatives with a potential as antimelanoma agents.
Melanoma research 1992;2(1):25-32.
1992: Anna Palumbo; Marco d'Ischia; G Misuraca; Giuseppe Prota
Skin depigmentation by hydroquinone: a chemical and biochemical insight.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 1992;Suppl 2():299-303.
1991: Alessandra Napolitano; Marco d'Ischia; Giuseppe Prota; M Havens; KM Tramposch
2-Aryl-1,3-thiazolidines as masked sulfhydryl agents for inhibition of melanogenesis.
Biochimica et biophysica acta 1991;1073(2):416-22.
1991: Marco d'Ischia; Alessandra Napolitano; Giuseppe Prota
Peroxidase as an alternative to tyrosinase in the oxidative polymerization of 5,6-dihydroxyindoles to melanin(s).
Biochimica et biophysica acta 1991;1073(2):423-30.
1991: Anna Palumbo; Marco d'Ischia; G Misuraca; Giuseppe Prota
Mechanism of inhibition of melanogenesis by hydroquinone.
Biochimica et biophysica acta 1991;1073(1):85-90.
1990: Anna Palumbo; Marco d'Ischia; G Misuraca; A Iannone; Giuseppe Prota
Selective uptake of 2-thiouracil into melanin-producing systems depends on chemical binding to enzymically generated dopaquinone.
Biochimica et biophysica acta 1990;1036(3):221-7.
1990: Anna Palumbo; Marco d'Ischia; G Misuraca; L Carratú; Giuseppe Prota
Activation of mammalian tyrosinase by ferrous ions.
Biochimica et biophysica acta 1990;1033(3):256-60.
1989: Marco d'Ischia; Alessandra Napolitano; Giuseppe Prota
Psoralens sensitize glutathione photooxidation in vitro.
Biochimica et biophysica acta 1989;993(2-3):143-7.
1989: Anna Palumbo; Marco d'Ischia; G Misuraca; Giuseppe Prota
A new look at the rearrangement of adrenochrome under biomimetic conditions.
Biochimica et biophysica acta 1989;990(3):297-302.
1988: Anna Palumbo; Marco d'Ischia; G Misuraca; Giuseppe Prota; T M Schultz
Structural modifications in biosynthetic melanins induced by metal ions.
Biochimica et biophysica acta 1988;964(2):193-9.
1987: Anna Palumbo; Marco d'Ischia; G Misuraca; Giuseppe Prota
Effect of metal ions on the rearrangement of dopachrome.
Biochimica et biophysica acta 1987;925(2):203-9.
1985: Anna Palumbo; G Misuraca; Marco d'Ischia; Giuseppe Prota
Effect of metal ions on the kinetics of tyrosine oxidation catalysed by tyrosinase.
The Biochemical journal 1985;228(3):647-51.
1983: Anna Palumbo; G Nardi; Marco d'Ischia; G Misuraca; Giuseppe Prota
Non-enzymic oxidation of cysteinyldopa catalyzed by metallic ions.
General pharmacology 1983;14(2):253-7.