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Klaus Dittmann

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Stephan M Huber; Claus Mayer; Milan Misovic; Hans-Peter Rodemann; Klaus Dittmann
EGFR-mediated stimulation of sodium/glucose cotransport promotes survival of irradiated human A549 lung adenocarcinoma cells.
Marc Steinle; Klaus Dittmann; Robert Lukowski; Milan Misovic; Daniela Palme; Justine Rudner; Peter Ruth; Stephan M Huber
Ionizing radiation induces migration of glioblastoma cells by activating BK K(+) channels.
Klaus Dittmann; Birgit Fehrenbacher; Rainer Kehlbach; Claus Mayer; Martin Schaller; H Peter Rodemann
Nuclear epidermal growth factor receptor modulates cellular radio-sensitivity by regulation of chromatin access.

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All Publications

2012: Stephan M Huber; Claus Mayer; Milan Misovic; Hans-Peter Rodemann; Klaus Dittmann
EGFR-mediated stimulation of sodium/glucose cotransport promotes survival of irradiated human A549 lung adenocarcinoma cells.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2012;103(3):373-9.
2011: Marc Steinle; Klaus Dittmann; Robert Lukowski; Milan Misovic; Daniela Palme; Justine Rudner; Peter Ruth; Stephan M Huber
Ionizing radiation induces migration of glioblastoma cells by activating BK K(+) channels.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2011;101(1):122-6.
2011: Klaus Dittmann; Birgit Fehrenbacher; Rainer Kehlbach; Claus Mayer; Martin Schaller; H Peter Rodemann
Nuclear epidermal growth factor receptor modulates cellular radio-sensitivity by regulation of chromatin access.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2011;99(3):317-22.
2010: Klaus Dittmann; Claus Mayer; Birgit Fehrenbacher; Martin Schaller; Rainer Kehlbach; H Peter Rodemann
Nuclear EGFR shuttling induced by ionizing radiation is regulated by phosphorylation at residue Thr654.
FEBS letters 2010;584(18):3878-84.
2010: Klaus Dittmann; Claus Mayer; H Peter Rodemann
Nuclear EGFR as novel therapeutic target: insights into nuclear translocation and function.
Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al] 2010;186(1):1-6.
2009: Klaus Dittmann; Claus Mayer; Rainer Kehlbach; Marie-Christine Rothmund; H Peter Rodemann
Radiation-induced lipid peroxidation activates src kinase and triggers nuclear EGFR transport.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2009;92(3):379-82.
2008: Mahmoud Toulany; Klaus Dittmann; Birgit Fehrenbacher; Martin Schaller; Michael Baumann; H Peter Rodemann
PI3K-Akt signaling regulates basal, but MAP-kinase signaling regulates radiation-induced XRCC1 expression in human tumor cells in vitro.
DNA repair 2008;7(10):1746-56.
2008: Klaus Dittmann; Claus Mayer; Rainer Kehlbach; H Peter Rodemann
The radioprotector Bowman-Birk proteinase inhibitor stimulates DNA repair via epidermal growth factor receptor phosphorylation and nuclear transport.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2008;86(3):375-82.
2008: Gabriele Wanner; Claus Mayer; Rainer Kehlbach; H Peter Rodemann; Klaus Dittmann
Activation of protein kinase Cepsilon stimulates DNA-repair via epidermal growth factor receptor nuclear accumulation.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2008;86(3):383-90.
2008: Klaus Dittmann; Claus Mayer; Rainer Kehlbach; H Peter Rodemann
Radiation-induced caveolin-1 associated EGFR internalization is linked with nuclear EGFR transport and activation of DNA-PK.
Molecular cancer 2008;7():69.
2008: Klaus Dittmann; Claus Mayer; Petra A Ohneseit; Uma Raju; Nicolaus Andratschke; Luka Milas; H Peter Rodemann
Celecoxib induced tumor cell radiosensitization by inhibiting radiation induced nuclear EGFR transport and DNA-repair: a COX-2 independent mechanism.
International journal of radiation oncology, biology, physics 2008;70(1):203-12.
2007: H Peter Rodemann; Klaus Dittmann; Mahmoud Toulany
Radiation-induced EGFR-signaling and control of DNA-damage repair.
International journal of radiation biology 2007;83(11-12):781-91.
2007: Klaus Dittmann; Claus Mayer; Gabriele Wanner; Rainer Kehlbach; H Peter Rodemann
The radioprotector O-phospho-tyrosine stimulates DNA-repair via epidermal growth factor receptor- and DNA-dependent kinase phosphorylation.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2007;84(3):328-34.
2007: Michael Baumann; Mechthild Krause; Ekkehard Dikomey; Klaus Dittmann; Wolfgang Dörr; Ulla Kasten-Pisula; H Peter Rodemann
EGFR-targeted anti-cancer drugs in radiotherapy: preclinical evaluation of mechanisms.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2007;83(3):238-48.
2007: Petra A Ohneseit; Guido Krebiehl; Klaus Dittmann; Rainer Kehlbach; H Peter Rodemann
Inhibition of cyclooxygenase-2 activity by celecoxib does not lead to radiosensitization of human prostate cancer cells in vitro.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2007;82(2):229-38.
2006: Mahmoud Toulany; Ulla Kasten-Pisula; Ingo Brammer; Shaomeng Wang; Jianyong Chen; Klaus Dittmann; Michael Baumann; Ekkehard Dikomey; H Peter Rodemann
Blockage of epidermal growth factor receptor-phosphatidylinositol 3-kinase-AKT signaling increases radiosensitivity of K-RAS mutated human tumor cells in vitro by affecting DNA repair.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(13):4119-26.
2005: Uma Raju; Hisanori Ariga; Klaus Dittmann; Eiko Nakata; K. Kian Ang; Luka Milas
Inhibition of DNA repair as a mechanism of enhanced radioresponse of head and neck carcinoma cells by a selective cyclooxygenase-2 inhibitor, celecoxib.
International journal of radiation oncology, biology, physics 2005;63(2):520-8.
2005: Klaus Dittmann; Claus Mayer; Birgit Fehrenbacher; Martin Schaller; Uma Raju; Luka Milas; David J Chen; Rainer Kehlbach; H Peter Rodemann
Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinase.
The Journal of biological chemistry 2005;280(35):31182-9.
2005: Mahmoud Toulany; Klaus Dittmann; Maren Krüger; Michael Baumann; H Peter Rodemann
Radioresistance of K-Ras mutated human tumor cells is mediated through EGFR-dependent activation of PI3K-AKT pathway.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2005;76(2):143-50.
2005: Klaus Dittmann; Claus Mayer; H Peter Rodemann
Inhibition of radiation-induced EGFR nuclear import by C225 (Cetuximab) suppresses DNA-PK activity.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2005;76(2):157-61.
2005: Klaus Dittmann; Mahmoud Toulany; Johannes Classen; Vanessa Heinrich; Luka Milas; H Peter Rodemann
Selective radioprotection of normal tissues by Bowman-birk proteinase inhibitor (BBI) in mice.
Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al] 2005;181(3):191-6.
2005: Mahmoud Toulany; Klaus Dittmann; Michael Baumann; H Peter Rodemann
Radiosensitization of Ras-mutated human tumor cells in vitro by the specific EGF receptor antagonist BIBX1382BS.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2005;74(2):117-29.
2004: Michael Baumann; Mechthild Krause; Daniel Zips; Cordula Petersen; Klaus Dittmann; Wolfgang Dörr; H Peter Rodemann
Molecular targeting in radiotherapy of lung cancer.
Lung cancer (Amsterdam, Netherlands) 2004;45 Suppl 2():S187-97.
2004: Nicolaus Andratschke; Klaus Dittmann; Kathryn A Mason; Zhen Fan; Zhongxing Liao; Ritsuko Komaki; K. Kian Ang; Luka Milas
Epidermal growth factor receptor as a target to improve treatment of lung cancer.
Clinical lung cancer 2004;5(6):340-52.
2003: Klaus Dittmann; Patricia Virsik-Köpp; Claus Mayer; Margret Rave-Fränk; H Peter Rodemann
Bowman-Birk protease inhibitor activates DNA-dependent protein kinase and reduces formation of radiation-induced dicentric chromosomes.
International journal of radiation biology 2003;79(10):801-8.
2003: Klaus Dittmann; Claus Mayer; H Peter Rodemann
Radioprotection of normal tissue to improve radiotherapy: the effect of the Bowman Birk protease inhibitor.
Current medicinal chemistry. Anti-cancer agents 2003;3(5):360-3.
2002: A Von Pfeil; L Hakenjos; Carsten Herskind; Klaus Dittmann; Michael Weller; H Peter Rodemann
Irradiated homozygous TGF-beta1 knockout fibroblasts show enhanced clonogenic survival as compared with TGF-beta1 wild-type fibroblasts.
International journal of radiation biology 2002;78(5):331-9.
2001: Klaus Dittmann; D Knaus-Dittmann; C Mayer; H Peter Rodemann
Bowman-Birk proteinase inhibitor-mediated radioprotection against UV irradiation is TP53-dependent and associated with stimulation of nucleotide excision repair.
Radiation and environmental biophysics 2001;40(2):163-7.
2001: Klaus Dittmann; Nuri Gueven; Claus Mayer; H Peter Rodemann
Characterization of the amino acids essential for the photo- and radioprotective effects of a Bowman-Birk protease inhibitor-derived nonapeptide.
Protein engineering 2001;14(3):157-60.
2001: Klaus Dittmann; Claus Mayer; H Peter Rodemann
O-phospho-L-tyrosine protects TP53 wild-type cells against ionizing radiation.
International journal of cancer. Journal international du cancer 2001;96 Suppl():1-6.
2000: Klaus Dittmann; Ekkehard Dikomey; Claus Mayer; H Peter Rodemann
The Bowman-Birk protease inhibitor enhances clonogenic cell survival of ionizing radiation-treated nucleotide excision repair-competent cells but not of xeroderma pigmentosum cells.
International journal of radiation biology 2000;76(2):223-9.
1998: Klaus Dittmann; Nuri Gueven; Claus Mayer; Petra A Ohneseit; R Zell; A C Begg; H Peter Rodemann
The presence of wild-type TP53 is necessary for the radioprotective effect of the Bowman-Birk proteinase inhibitor in normal fibroblasts.
Radiation research 1998;150(6):648-55.
1998: Klaus Dittmann; Nuri Gueven; Claus Mayer; H Peter Rodemann
The radioprotective effect of BBI is associated with the activation of DNA repair-relevant genes.
International journal of radiation biology 1998;74(2):225-30.
1998: Nuri Gueven; Klaus Dittmann; C Mayer; H Peter Rodemann
The radioprotective potential of the Bowman-Birk protease inhibitor is independent of its secondary structure.
Cancer letters 1998;125(1-2):77-82.
1998: Nuri Gueven; Klaus Dittmann; Claus Mayer; H Peter Rodemann
Bowman-Birk protease inhibitor reduces the radiation-induced activation of the EGF receptor and induces tyrosine phosphatase activity.
International journal of radiation biology 1998;73(2):157-62.
1998: Klaus Dittmann; C Mayer; H Peter Rodemann; P E Petrides; Claudio Denzlinger
MK-886, a leukotriene biosynthesis inhibitor, induces antiproliferative effects and apoptosis in HL-60 cells.
Leukemia research 1998;22(1):49-53.
1996: Christian Ries; F Lottspeich; Klaus Dittmann; Petro E Petrides
HL-60 leukemia cells produce an autocatalytically truncated form of matrix metalloproteinase-9 with impaired sensitivity to inhibition by tissue inhibitors of metalloproteinases.
Leukemia 1996;10(9):1520-6.
1995: Klaus Dittmann; F Lottspeich; Christian Ries; Petro E Petrides
Leukemic cells (HL-60) produce a novel extracellular matrix-degrading proteinase that is not inhibited by tissue inhibitors of matrix metalloproteinases (TIMPs).
Experimental hematology 1995;23(2):155-60.
1995: Klaus Dittmann; H Löffler; D D; H Peter Rodemann
Bowman-Birk proteinase inhibitor (BBI) modulates radiosensitivity and radiation-induced differentiation of human fibroblasts in culture.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 1995;34(2):137-43.
1991: Klaus Dittmann; Petro E Petrides
A 41 kDa transferrin related molecule acts as an autocrine growth factor for HL-60 cells.
Biochemical and biophysical research communications 1991;176(1):473-8.
1990: Petro E Petrides; Klaus Dittmann
How do normal and leukemic white blood cells egress from the bone marrow? Morphological facts and biochemical riddles.
Blut 1990;61(1):3-13.
1989: H P Rodemann; K Bayreuther; P I Francz; Klaus Dittmann; M Albiez
Selective enrichment and biochemical characterization of seven human skin fibroblasts cell types in vitro.
Experimental cell research 1989;180(1):84-93.
1988: K Bayreuther; H P Rodemann; R Hommel; Klaus Dittmann; M Albiez; P I Francz
Human skin fibroblasts in vitro differentiate along a terminal cell lineage.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(14):5112-6.