FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

David Dix

Research Profile

Chemicals & Drugs

Organizations

United States Environmental Protection Agency

Living Beings

Rats
Mouse

Procedures

Devices

Oligonucleotide Array Sequence Analysis

Geographic Areas

United States

Anatomy

Concepts & Ideas

Physiology

Gene Expression Regulation

Co-author Network

Publications

TOP 3
Nicole C Kleinstreuer; Thomas B Knudsen; Matthew T Martin; Katie B Paul; David M Reif; Imran Shah; Kevin M Crofton; David J Dix; Kerry Hamilton; Keith A Houck; Ronald Hunter; Robert J Kavlock; Richard S Judson
In vitro perturbations of targets in cancer hallmark processes predict rodent chemical carcinogenesis.
David J Dix; Keith A Houck; Richard S Judson; Nicole C Kleinstreuer; Thomas B Knudsen; Matthew T Martin; David M Reif; Ann M Richard; Imran Shah; Nisha S Sipes; Robert Kavlock
Incorporating biological, chemical, and toxicological knowledge into predictive models of toxicity.
Ila Cote; David J Dix; Stephen Wilton Edwards; Paul T Anastas; Linda S Birnbaum; Rebecca M Clark; Peter W Preuss
Advancing the next generation of health risk assessment.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of David Dix (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Nicole C Kleinstreuer; Thomas B Knudsen; Matthew T Martin; Katie B Paul; David M Reif; Imran Shah; Kevin M Crofton; David J Dix; Kerry Hamilton; Keith A Houck; Ronald Hunter; Robert J Kavlock; Richard S Judson
In vitro perturbations of targets in cancer hallmark processes predict rodent chemical carcinogenesis.
Toxicological sciences : an official journal of the Society of Toxicology 2013;131(1):40-55.
2012: David J Dix; Keith A Houck; Richard S Judson; Nicole C Kleinstreuer; Thomas B Knudsen; Matthew T Martin; David M Reif; Ann M Richard; Imran Shah; Nisha S Sipes; Robert Kavlock
Incorporating biological, chemical, and toxicological knowledge into predictive models of toxicity.
Toxicological sciences : an official journal of the Society of Toxicology 2012;130(2):440-1; author reply 442-3.
2012: Ila Cote; David J Dix; Stephen Wilton Edwards; Paul T Anastas; Linda S Birnbaum; Rebecca M Clark; Peter W Preuss
Advancing the next generation of health risk assessment.
Environmental health perspectives 2012;120(11):1499-502.
2012: Stephanie Padilla; Beth Padnos; N Sipes; A Beam; D Corum; David J Dix; K A Houck; Deborah L Hunter; N Kleinstreuer; Amar Singh; D M Reif
Zebrafish developmental screening of the ToxCast™ Phase I chemical library.
Reproductive toxicology (Elmsford, N.Y.) 2012;33(2):174-87.
2011: N C Kleinstreuer; Amar Singh; J A Palmer; A M Smith; A M Weir-Hauptman; P R West; K R Conard; David J Dix; E L R Donley; B R Fontaine; G G Cezar
Identifying developmental toxicity pathways for a subset of ToxCast chemicals using human embryonic stem cells and metabolomics.
Toxicology and applied pharmacology 2011;257(1):111-21.
2011: Nisha S Sipes; Matthew T Martin; David M Reif; Amar Singh; Kelly J Chandler; David J Dix; Richard S Judson; Robert Kavlock; Nicole C Kleinstreuer; Thomas B Knudsen
Predictive models of prenatal developmental toxicity from ToxCast high-throughput screening data.
Toxicological sciences : an official journal of the Society of Toxicology 2011;124(1):109-27.
2011: Nicole C Kleinstreuer; David M Reif; Amar V Singh; Nisha S Sipes; Kelly J Chandler; Rob Dewoskin; David J Dix; Richard S Judson; Robert Kavlock; Amar Singh
Environmental impact on vascular development predicted by high-throughput screening.
Environmental health perspectives 2011;119(11):1596-603.
2011: Sumit Gangwal; Keith A Houck; James S Brown; David J Dix; Robert Kavlock; Amy Wang; Elaine A Cohen Hubal
Informing selection of nanomaterial concentrations for ToxCast in vitro testing based on occupational exposure potential.
Environmental health perspectives 2011;119(11):1539-46.
2011: Matthew T Martin; David M Reif; Keith A Houck; Richard S Judson; Robert J Kavlock; Thomas B Knudsen; David J Dix
Predictive model of rat reproductive toxicity from ToxCast high throughput screening.
Biology of reproduction 2011;85(2):327-39.
2011: Richard S Judson; Robert J Kavlock; R Woodrow Setzer; Elaine A Cohen Hubal; Matthew T Martin; Thomas B Knudsen; Keith A Houck; Russell S Thomas; Barbara A Wetmore; David J Dix
Estimating toxicity-related biological pathway altering doses for high-throughput chemical risk assessment.
Chemical research in toxicology 2011;24(4):451-62.
2011: Amar Singh; Keith A Houck; Nisha S Sipes; Amar V Singh; Richard S Judson; Matthew T Martin; Arthur Weissman; Nicole C Kleinstreuer; Holly M Mortensen; David M Reif; James R Rabinowitz; R Woodrow Setzer; Ann M Richard; David J Dix; Robert Kavlock
Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets.
Toxicology 2011;282(1-2):1-15.
2011: Kelly J Chandler; David J Dix; E Sidney Hunter; Susan C Jeffay; Richard S Judson; Robert Kavlock; Nicole C Kleinstreuer; Harriette P Nichols; David M Reif; Amar Singh; Nisha S Sipes; Marianne Barrier; Thomas B Knudsen
Evaluation of 309 environmental chemicals using a mouse embryonic stem cell adherent cell differentiation and cytotoxicity assay.
PloS one 2011;6(6):e18540.
2011: Imran Shah; Keith Houck; Richard S Judson; Robert J Kavlock; Matthew T Martin; David M Reif; John Wambaugh; David J Dix
Using nuclear receptor activity to stratify hepatocarcinogens.
PloS one 2011;6(2):e14584.
2010: David M Reif; Matthew T Martin; Shirlee W Tan; Keith A Houck; Richard S Judson; Ann M Richard; Thomas B Knudsen; David J Dix; Robert Kavlock
Endocrine profiling and prioritization of environmental chemicals using ToxCast data.
Environmental health perspectives 2010;118(12):1714-20.
2010: Daniel M Rotroff; Barbara A Wetmore; David J Dix; Stephen S Ferguson; Harvey J Clewell; Keith A Houck; Edward L Lecluyse; Melvin E Andersen; Richard S Judson; Cornelia M Smith; Mark A Sochaski; Robert J Kavlock; Frank Boellmann; Matthew T Martin; David M Reif; John F Wambaugh; Russell S Thomas
Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening.
Toxicological sciences : an official journal of the Society of Toxicology 2010;117(2):348-58.
2010: Richard S Judson; Matthew T Martin; David M Reif; Keith A Houck; Thomas B Knudsen; Daniel M Rotroff; Menghang Xia; Srilatha Sakamuru; Ruili Huang; Paul Shinn; Christopher P Austin; Robert J Kavlock; David J Dix
Analysis of eight oil spill dispersants using rapid, in vitro tests for endocrine and other biological activity.
Environmental science & technology 2010;44(15):5979-85.
2010: Richard S Judson; Keith A Houck; Robert J Kavlock; Thomas B Knudsen; Matthew T Martin; Holly M Mortensen; David M Reif; Daniel M Rotroff; Imran Shah; Ann M Richard; David J Dix
In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast project.
Environmental health perspectives 2010;118(4):485-92.
2010: Matthew T Martin; David J Dix; Richard S Judson; Robert J Kavlock; David M Reif; Ann M Richard; Daniel M Rotroff; Sergei Romanov; Alexander Medvedev; Natalia Poltoratskaya; Maria Gambarian; Matt Moeser; Sergei S Makarov; Keith A Houck
Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program.
Chemical research in toxicology 2010;23(3):578-90.
2010: Daniel M Rotroff; Andrew L Beam; David J Dix; Adam Farmer; Kimberly M Freeman; Keith A Houck; Richard S Judson; Edward L LeCluyse; Matthew T Martin; David M Reif; Stephen S Ferguson
Xenobiotic-metabolizing enzyme and transporter gene expression in primary cultures of human hepatocytes modulated by ToxCast chemicals.
Journal of toxicology and environmental health. Part B, Critical reviews 2010;13(2-4):329-46.
2010: Robert Kavlock; David J Dix
Computational toxicology as implemented by the U.S. EPA: providing high throughput decision support tools for screening and assessing chemical exposure, hazard and risk.
Journal of toxicology and environmental health. Part B, Critical reviews 2010;13(2-4):197-217.
2009: Amber K Goetz; John C Rockett; Hongzu Ren; Inthirany Thillainadarajah; David J Dix
Inhibition of rat and human steroidogenesis by triazole antifungals.
Systems biology in reproductive medicine 2009;55(5-6):214-26.
2009: Keith A Houck; David J Dix; Richard S Judson; Robert J Kavlock; Jian Yang; Ellen L Berg
Profiling bioactivity of the ToxCast chemical library using BioMAP primary human cell systems.
Journal of biomolecular screening 2009;14(9):1054-66.
2009: Thomas B Knudsen; Matthew T Martin; Robert Kavlock; Richard S Judson; David J Dix; Amar Singh
Profiling the activity of environmental chemicals in prenatal developmental toxicity studies using the U.S. EPA's ToxRefDB.
Reproductive toxicology (Elmsford, N.Y.) 2009;28(2):209-19.
2009: Amber K Goetz; David J Dix
Mode of action for reproductive and hepatic toxicity inferred from a genomic study of triazole antifungals.
Toxicological sciences : an official journal of the Society of Toxicology 2009;110(2):449-62.
2009: Amber K Goetz; David J Dix
Toxicogenomic effects common to triazole antifungals and conserved between rats and humans.
Toxicology and applied pharmacology 2009;238(1):80-9.
2009: Matthew T Martin; Elizabeth Mendez; Daniel G Corum; Richard S Judson; Robert J Kavlock; Daniel M Rotroff; David J Dix
Profiling the reproductive toxicity of chemicals from multigeneration studies in the toxicity reference database.
Toxicological sciences : an official journal of the Society of Toxicology 2009;110(1):181-90.
2009: Richard Judson; Ann Richard; David J Dix; Keith Houck; Matthew Martin; Robert Kavlock; Vicki Dellarco; Tala Henry; Todd Holderman; Philip Sayre; Shirlee Tan; Thomas Carpenter; Edwin Smith
The toxicity data landscape for environmental chemicals.
Environmental health perspectives 2009;117(5):685-95.
2009: Matthew T Martin; Richard S Judson; David M Reif; Robert Kavlock; David J Dix
Profiling chemicals based on chronic toxicity results from the U.S. EPA ToxRef Database.
Environmental health perspectives 2009;117(3):392-9.
2008: Richard Judson; Ann Richard; David J Dix; Keith Houck; Fathi Elloumi; Matthew Martin; Tommy Cathey; Thomas R Transue; Richard Spencer; Maritja Wolf
ACToR--Aggregated Computational Toxicology Resource.
Toxicology and applied pharmacology 2008;233(1):7-13.
2008: Robert Kavlock; Gerald T Ankley; Jerry Blancato; Michael Breen; Rory B Conolly; David J Dix; Keith Houck; Elaine Hubal; Richard Judson; James Rabinowitz; Ann Richard; R Woodrow Setzer; Imran Shah; Daniel Villeneuve; Eric Weber
Computational toxicology--a state of the science mini review.
Toxicological sciences : an official journal of the Society of Toxicology 2008;103(1):14-27.
2007: Sung Jae Kim; David J Dix; Kary E Thompson; Rachel N Murrell; Judith E Schmid; Jane E Gallagher; John C Rockett
Effects of storage, RNA extraction, genechip type, and donor sex on gene expression profiling of human whole blood.
Clinical chemistry 2007;53(6):1038-45.
2007: Matthew T Martin; Richard Brennan; Wenyue Hu; Eser Ayanoglu; Christopher Lau; Hongzu Ren; Carmen R Wood; J Christopher Corton; Robert Kavlock; David J Dix
Toxicogenomic study of triazole fungicides and perfluoroalkyl acids in rat livers predicts toxicity and categorizes chemicals based on mechanisms of toxicity.
Toxicological sciences : an official journal of the Society of Toxicology 2007;97(2):595-613.
2007: Adrian E Platts; David J Dix; Hector E Chemes; Kary E Thompson; Robert J Goodrich; John C Rockett; Vanesa Y Rawe; Silvina Quintana; Michael Diamond; Lillian F Strader; Stephen A Krawetz
Success and failure in human spermatogenesis as revealed by teratozoospermic RNAs.
Human molecular genetics 2007;16(7):763-73.
2007: Guobin Sun; Rachel D Grindstaff; Sheau-Fung Thai; Guy Lambert; Douglas B Tully; David J Dix; Stephen Nesnow
Induction of cytochrome P450 enzymes in rat liver by two conazoles, myclobutanil and triadimefon.
Xenobiotica; the fate of foreign compounds in biological systems 2007;37(2):180-93.
2007: Amber K Goetz; Hongzu Ren; Judith E Schmid; Chad R Blystone; Inthirany Thillainadarajah; Deborah S Best; Harriette P Nichols; Lillian F Strader; Douglas Wolf; Michael G Narotsky; John C Rockett; David J Dix
Disruption of testosterone homeostasis as a mode of action for the reproductive toxicity of triazole fungicides in the male rat.
Toxicological sciences : an official journal of the Society of Toxicology 2007;95(1):227-39.
2007: David J Dix; Keith A Houck; Matthew T Martin; Ann M Richard; R Woodrow Setzer; Robert Kavlock
The ToxCast program for prioritizing toxicity testing of environmental chemicals.
Toxicological sciences : an official journal of the Society of Toxicology 2007;95(1):5-12.
2006: John C Rockett; Michael G Narotsky; Kary E Thompson; Inthirany Thillainadarajah; Chad R Blystone; Amber K Goetz; Hongzu Ren; Deborah S Best; Rachel N Murrell; Harriette P Nichols; Judith E Schmid; Douglas Wolf; David J Dix
Effect of conazole fungicides on reproductive development in the female rat.
Reproductive toxicology (Elmsford, N.Y.) 2006;22(4):647-58.
2006: Amber K Goetz; Wenjun Bao; Hongzu Ren; Judith E Schmid; Douglas B Tully; Carmen Wood; John C Rockett; Michael G Narotsky; Guobin Sun; Guy Lambert; Sheau-Fung Thai; Douglas Wolf; Stephen Nesnow; David J Dix
Gene expression profiling in the liver of CD-1 mice to characterize the hepatotoxicity of triazole fungicides.
Toxicology and applied pharmacology 2006;215(3):274-84.
2006: Douglas B Tully; Wenjun Bao; Amber K Goetz; Chad R Blystone; Hongzu Ren; Judith E Schmid; Lillian F Strader; Carmen R Wood; Deborah S Best; Michael G Narotsky; Douglas Wolf; John C Rockett; David J Dix
Gene expression profiling in liver and testis of rats to characterize the toxicity of triazole fungicides.
Toxicology and applied pharmacology 2006;215(3):260-73.
2006: H A Barton; J Tang; Y M Sey; J P Stanko; Rachel N Murrell; John C Rockett; David J Dix
Metabolism of myclobutanil and triadimefon by human and rat cytochrome P450 enzymes and liver microsomes.
Xenobiotica; the fate of foreign compounds in biological systems 2006;36(9):793-806.
2006: David J Dix; Kathryn Gallagher; William H Benson; Brenda L Groskinsky; J Thomas McClintock; Kerry L Dearfield; William H Farland
A framework for the use of genomics data at the EPA.
Nature biotechnology 2006;24(9):1108-11.
2006: Guobin Sun; Sheau-Fung Thai; Guy Lambert; Douglas Wolf; Douglas B Tully; Amber K Goetz; Michael H George; Rachel D Grindstaff; David J Dix; Stephen Nesnow
Fluconazole-induced hepatic cytochrome P450 gene expression and enzymatic activities in rats and mice.
Toxicology letters 2006;164(1):44-53.
2006: Sung Jae Kim; David J Dix; Kary E Thompson; Rachel N Murrell; Judith E Schmid; Jane E Gallagher; John C Rockett
Gene expression in head hair follicles plucked from men and women.
Annals of clinical and laboratory science 2006;36(2):115-26.
2005: G Charles Ostermeier; Robert J Goodrich; Michael Diamond; David J Dix; Stephen A Krawetz
Toward using stable spermatozoal RNAs for prognostic assessment of male factor fertility.
Fertility and sterility 2005;83(6):1687-94.
2005: Guobin Sun; Sheau-Fung Thai; Douglas B Tully; Guy Lambert; Amber K Goetz; Douglas Wolf; David J Dix; Stephen Nesnow
Propiconazole-induced cytochrome P450 gene expression and enzymatic activities in rat and mouse liver.
Toxicology letters 2005;155(2):277-87.
2005: Wenjun Bao; Judith E Schmid; Amber K Goetz; Hongzu Ren; David J Dix
A database for tracking toxicogenomic samples and procedures.
Reproductive toxicology (Elmsford, N.Y.) 2005;19(3):411-9.
2005: Douglas B Tully; J Christopher Luft; John C Rockett; Hongzu Ren; Judith E Schmid; Carmen R Wood; David J Dix
Reproductive and genomic effects in testes from mice exposed to the water disinfectant byproduct bromochloroacetic acid.
Reproductive toxicology (Elmsford, N.Y.) 2005;19(3):353-66.
2004: John C Rockett; Pasquale Patrizio; Judith E Schmid; Norman B Hecht; David J Dix
Gene expression patterns associated with infertility in humans and rodent models.
Mutation research 2004;549(1-2):225-40.
2004: John C Rockett; Michael Burczynski; Albert J Fornace; Paul C Herrmann; Stephen A Krawetz; David J Dix
Surrogate tissue analysis: monitoring toxicant exposure and health status of inaccessible tissues through the analysis of accessible tissues and cells.
Toxicology and applied pharmacology 2004;194(2):189-99.
2002: G Charles Ostermeier; David J Dix; David Miller; Purvesh Khatri; Stephen A Krawetz
Spermatozoal RNA profiles of normal fertile men.
Lancet 2002;360(9335):772-7.
2002: John C Rockett; Robert Kavlock; Christy Lambright; Louise G Parks; Judith E Schmid; Vickie S Wilson; Carmen Wood; David J Dix
DNA arrays to monitor gene expression in rat blood and uterus following 17beta-estradiol exposure: biomonitoring environmental effects using surrogate tissues.
Toxicological sciences : an official journal of the Society of Toxicology 2002;69(1):49-59.
2002: G Charles Ostermeier; David J Dix; Stephen A Krawetz
A bioinformatic strategy to rapidly characterize cDNA libraries.
Bioinformatics (Oxford, England) 2002;18(7):949-52.
2002: J A Barnes; BW Collins; David J Dix; James W Allen
Effects of heat shock protein 70 (Hsp70) on arsenite-induced genotoxicity.
Environmental and molecular mutagenesis 2002;40(4):236-42.
2001: J Christopher Luft; I J Benjamin; Ruben Mestril; David J Dix
Heat shock factor 1-mediated thermotolerance prevents cell death and results in G2/M cell cycle arrest.
Cell stress & chaperones 2001;6(4):326-36.
2001: J A Barnes; David J Dix; BW Collins; C Luft; James W Allen
Expression of inducible Hsp70 enhances the proliferation of MCF-7 breast cancer cells and protects against the cytotoxic effects of hyperthermia.
Cell stress & chaperones 2001;6(4):316-25.
2001: E Sidney Hunter; David J Dix
Heat shock proteins Hsp70-1 and Hsp70-3 Are necessary and sufficient to prevent arsenite-induced dysmorphology in mouse embryos.
Molecular reproduction and development 2001;59(3):285-93.
2001: John C Rockett; F L Mapp; J B Garges; J Christopher Luft; Chisato Mori; David J Dix
Effects of hyperthermia on spermatogenesis, apoptosis, gene expression, and fertility in adult male mice.
Biology of reproduction 2001;65(1):229-39.
2001: John C Rockett; J Christopher Luft; J Brian Garges; Stephen A Krawetz; M R Hughes; K Hee Kirn; A J Oudes; David J Dix
Development of a 950-gene DNA array for examining gene expression patterns in mouse testis.
Genome biology 2001;2(4):RESEARCH0014.
2000: John C Rockett; David J Dix
DNA arrays: technology, options and toxicological applications.
Xenobiotica; the fate of foreign compounds in biological systems 2000;30(2):155-77.
1999: J Christopher Luft; David J Dix
Hsp70 expression and function during embryogenesis.
Cell stress & chaperones 1999;4(3):162-70.
1999: Chisato Mori; J W Allen; David J Dix; N Nakamura; M Fujioka; Kiyotaka Toshimori; Edward Eddy
Completion of meiosis is not always required for acrosome formation in HSP70-2 null mice.
Biology of reproduction 1999;61(3):813-22.
1999: John C Rockett; David J Dix
Application of DNA arrays to toxicology.
Environmental health perspectives 1999;107(8):681-5.
1998: David J Dix; J B Garges; R L Hong
Inhibition of hsp70-1 and hsp70-3 expression disrupts preimplantation embryogenesis and heightens embryo sensitivity to arsenic.
Molecular reproduction and development 1998;51(4):373-80.
1997: David J Dix; James W Allen; BW Collins; P Poorman-Allen; Chisato Mori; D R Blizard; Paula R Brown; Eugenia H Goulding; B D Strong; Edward Eddy
HSP70-2 is required for desynapsis of synaptonemal complexes during meiotic prophase in juvenile and adult mouse spermatocytes.
Development (Cambridge, England) 1997;124(22):4595-603.
1997: D Zhu; David J Dix; Edward Eddy
HSP70-2 is required for CDC2 kinase activity in meiosis I of mouse spermatocytes.
Development (Cambridge, England) 1997;124(15):3007-14.
1997: David J Dix
Hsp70 expression and function during gametogenesis.
Cell stress & chaperones 1997;2(2):73-7.
1997: C Mori; N Nakamura; David J Dix; M Fujioka; S Nakagawa; Kohei Shiota; Edward Eddy
Morphological analysis of germ cell apoptosis during postnatal testis development in normal and Hsp 70-2 knockout mice.
Developmental dynamics : an official publication of the American Association of Anatomists 1997;208(1):125-36.