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Shantu Amin

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Konstantin Kropachev; Zhi Liu; Adam G Schwaid; Lu Zhang; Shantu Amin; Suse Broyde; Yuqin Cai; Shuang Ding; Alexander Kolbanovskiy; Marina Kolbanovskiy; Nicholas E Geacintov
Adenine-DNA Adducts Derived from the Highly Tumorigenic Dibenzo[a,l]pyrene Are Resistant to Nucleotide Excision Repair while Guanine Adducts Are Not.
Arun K Sharma; Shantu Amin
Post SELECT: selenium on trial.
Joshua E Allen; Shantu Amin; David T Dicker; Jean-Nicolas Gallant; Rosalyn B Irby; Arun K Sharma; Wafik S El-Deiry
The Akt inhibitor ISC-4 synergizes with cetuximab in 5-FU-resistant colon cancer.

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All Publications

2013: Konstantin Kropachev; Zhi Liu; Adam G Schwaid; Lu Zhang; Shantu Amin; Suse Broyde; Yuqin Cai; Shuang Ding; Alexander Kolbanovskiy; Marina Kolbanovskiy; Nicholas E Geacintov
Adenine-DNA Adducts Derived from the Highly Tumorigenic Dibenzo[a,l]pyrene Are Resistant to Nucleotide Excision Repair while Guanine Adducts Are Not.
Chemical research in toxicology 2013;26(5):783-93.
2013: Arun K Sharma; Shantu Amin
Post SELECT: selenium on trial.
Future medicinal chemistry 2013;5(2):163-74.
2013: Joshua E Allen; Shantu Amin; David T Dicker; Jean-Nicolas Gallant; Rosalyn B Irby; Arun K Sharma; Wafik S El-Deiry
The Akt inhibitor ISC-4 synergizes with cetuximab in 5-FU-resistant colon cancer.
PloS one 2013;8(3):e59380.
2013: Raghavendra Gowda; Subbarao V Madhunapantula; Shantu Amin; Dhimant Desai; Gavin P. Robertson
Simultaneous targeting of COX-2 and AKT using selenocoxib-1-GSH to inhibit melanoma.
Molecular cancer therapeutics 2013;12(1):3-15.
2012: Yijin Tang; Shantu Amin; Suse Broyde; Yuqin Cai; Shuang Ding; Donald M Jerina; Chin H Lin; Zhi Liu; Fabian A Rodriguez; Jane M Sayer; Nicholas E Geacintov
Nuclear magnetic resonance solution structure of an N(2)-guanine DNA adduct derived from the potent tumorigen dibenzo[a,l]pyrene: intercalation from the minor groove with ruptured Watson-Crick base pairing.
Biochemistry 2012;51(48):9751-62.
2012: Julie B Ealy; Jacek Krzeminski; Malgorzata Sudol; Shantu Amin; Michael Katzman
Alternative nucleophilic substrates for the endonuclease activities of human immunodeficiency virus type 1 integrase.
Virology 2012;433(1):149-56.
2012: Melissa A Crampsie; Dhimant Desai; Manoj K Pandey; Shantu Amin; Julian Spallholz; Arun K Sharma
Phenylalkyl isoselenocyanates vs phenylalkyl isothiocyanates: thiol reactivity and its implications.
Chemico-biological interactions 2012;200(1):28-37.
2012: Mi Sun Moon; Bruce Stanley; Junjia Zhu; Cesar Aliaga; Shantu Amin; Jacek Krzeminski; Emily I McDevitt; Thomas G Miller; Harriet C Isom
Elevated hepatic iron activates NF-E2-related factor 2-regulated pathway in a dietary iron overload mouse model.
Toxicological sciences : an official journal of the Society of Toxicology 2012;129(1):74-85.
2012: Gitanjali A Narayanan; Shantu Amin; Gowdahalli Krishnegowda; Iain A Murray; Gary H Perdew
Selective aryl hydrocarbon receptor modulator-mediated repression of CD55 expression induced by cytokine exposure.
The Journal of pharmacology and experimental therapeutics 2012;342(2):345-55.
2012: Raghavendra Gowda; Subbarao V Madhunapantula; Shantu Amin; Dhimant Desai; Gavin P. Robertson
Selenium-containing histone deacetylase inhibitors for melanoma management.
Cancer biology & therapy 2012;13(9):756-65.
2012: A S Prakasha Gowda; Gowdahalli Krishnegowda; Shantu Amin; Zucai Suo; Thomas E Spratt
Low fidelity bypass of O(2)-(3-pyridyl)-4-oxobutylthymine, the most persistent bulky adduct produced by the tobacco specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by model DNA polymerases.
Chemical research in toxicology 2012;25(6):1195-202.
2012: Joseph B Guttenplan; Kun Jiang; Wieslawa Kosinska; Arun K Sharma; Yuan-Wan Sun; Shang-Min Zhang; Zhong-Lin Zhao; Kwangmi Ahn; Cesar Aliaga; Shantu Amin; Richard Bruggeman; Kun-Ming Chen; Timothy Cooper; Joseph DelTondo; Karam El-Bayoumy
Mutagenesis and carcinogenesis induced by dibenzo[a,l]pyrene in the mouse oral cavity: a potential new model for oral cancer.
International journal of cancer. Journal international du cancer 2012;130(12):2783-90.
2012: Sans W Emmert; Yuan-Wan Sun; Cesar Aliaga; Shantu Amin; Arunangshu Das; Dhimant Desai; Karam El-Bayoumy; John P Richie
Induction of lung glutathione and glutamylcysteine ligase by 1,4-phenylenebis(methylene)selenocyanate and its glutathione conjugate: role of nuclear factor-erythroid 2-related factor 2.
Free radical biology & medicine 2012;52(10):2064-71.
2012: Jyh Ming Lin; A S Prakasha Gowda; Arun K Sharma; Shantu Amin
In vitro growth inhibition of human cancer cells by novel honokiol analogs.
Bioorganic & medicinal chemistry 2012;20(10):3202-11.
2012: Megan M Young; Jong Yun; Jianke Zhang; Shantu Amin; Tsukasa Hori; Chang-Deng Hu; Mark Kester; Osman Khan; Sungman Park; Arun K Sharma; Yoshinori Takahashi; Hong-Gang Wang
Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis.
The Journal of biological chemistry 2012;287(15):12455-68.
2012: Kenichiro Doi; Gowdahalli Krishnegowda; Rongshi Li; Xin Liu; Yan Liu; Thomas P Loughran; Wanda Manieri; Yong Qin; Ernst Schonbrunn; Said Sebti; Shen-Shu Sung; Shantu Amin; Andy Awwad; Chunwei Cheng; Gary Daughdrill; Alden Dewey; Hongwei Wu; Hong-Gang Wang
Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation.
The Journal of biological chemistry 2012;287(13):10224-35.
2012: Kun-Ming Chen; Timothy Cooper; Cesar Aliaga; Shantu Amin; Krishnegowda Gowdahalli; Yuan-Wan Sun; Shang-Min Zhang; Junjia Zhu; Karam El-Bayoumy
Induction of ovarian cancer and DNA adducts by Dibenzo[a,l]pyrene in the mouse.
Chemical research in toxicology 2012;25(2):374-80.
2012: Eun-Ryeong Hahm; Shantu Amin; Kumar Chandra-Kuntal; Dhimant Desai; Shivendra V Singh
Notch activation is dispensable for D, L-sulforaphane-mediated inhibition of human prostate cancer cell migration.
PloS one 2012;7(9):e44957.
2012: Yan Cheng; Kathryn J Huber-Keener; Jason Liao; Xingcong Ren; Arun K Sharma; Ugir Hossain Sk; Yuan-Wan Sun; Li Zhang; Yi Zhang; Shantu Amin; Jin-Ming Yang
Rational incorporation of selenium into temozolomide elicits superior antitumor activity associated with both apoptotic and autophagic cell death.
PloS one 2012;7(4):e35104.
2011: Mi Sun Moon; John P Richie; Junjia Zhu; Cesar Aliaga; Shantu Amin; Boo-Hyon Kang; Susan Kocher; Jacek Krzeminski; Emily I McDevitt; Harriet C Isom
3,5,5-trimethyl-hexanoyl-ferrocene diet protects mice from moderate transient acetaminophen-induced hepatotoxicity.
Toxicological sciences : an official journal of the Society of Toxicology 2011;124(2):348-58.
2011: Melissa A Crampsie; Arunangshu Das; Dhimant Desai; Nathan Jones; Philip Lazarus; Cesar Aliaga; Shantu Amin; Arun K Sharma
Phenylbutyl isoselenocyanate modulates phase I and II enzymes and inhibits 4-(methylnitrosamino)-1-(3-pyridyl)- 1-butanone-induced DNA adducts in mice.
Cancer prevention research (Philadelphia, Pa.) 2011;4(11):1884-94.
2011: Dara A Reeves; Shantu Amin; Suse Broyde; Yuqin Cai; Ying Chen; Shuang Ding; Alexander Kolbanovskiy; Marina Kolbanovskiy; Konstantin Kropachev; Jacek Krzeminski; Hong Mu; Dinshaw J Patel; Nicholas E Geacintov
Resistance of bulky DNA lesions to nucleotide excision repair can result from extensive aromatic lesion-base stacking interactions.
Nucleic acids research 2011;39(20):8752-64.
2011: Gowdahalli Krishnegowda; A S Prakasha Gowda; Arun K Sharma; Hephzibah Rani S Tagaram; Kevin F Staveley-O' Carroll; Rosalyn B Irby; Shantu Amin
Synthesis and biological evaluation of a novel class of isatin analogs as dual inhibitors of tubulin polymerization and Akt pathway.
Bioorganic & medicinal chemistry 2011;19(20):6006-14.
2011: Kristine C Olson; Ira J Ropson; Arun K Sharma; Thomas E Spratt; Dongxiao Sun; Shantu Amin; Gang Chen; Philip Lazarus
Characterization of dibenzo[a,l]pyrene-trans-11,12-diol (dibenzo[def,p]chrysene) glucuronidation by UDP-glucuronosyltransferases.
Chemical research in toxicology 2011;24(9):1549-59.
2011: Aijun Liao; Jason Liao; Cesar Aliaga; Shantu Amin; Kendall Thomas Baab; Kathleen Broeg; Dhimant Desai; Alden Dewey; Todd Fox; Leah Hirsch; Nancy Ruth Jarbadan; Mark Kester; Yongping Li; Kelly Loughran; Thomas P Loughran; Andrew Rogers; Lindsay Ryland; Mithun Vinod Shah; Su-Fern Tan; Hong-Gang Wang; Rebecca Watters; Jun Yang; Lucy Q Zhang; Xin Liu
Therapeutic efficacy of FTY720 in a rat model of NK-cell leukemia.
Blood 2011;118(10):2793-800.
2011: Shang-Min Zhang; Jyh-Ming Lin; Arun K Sharma; Yuan-Wan Sun; Cesar Aliaga; Shantu Amin; Kun-Ming Chen; Karam El-Bayoumy
Identification and quantification of DNA adducts in the oral tissues of mice treated with the environmental carcinogen dibenzo[a,l]pyrene by HPLC-MS/MS.
Chemical research in toxicology 2011;24(8):1297-303.
2011: Ugir Hossain Sk; Thomas E Spratt; Jong K Yun; Shantu Amin; Melissa A Crampsie; A S Prakasha Gowda; Arun K Sharma
Development of novel naphthalimide derivatives and their evaluation as potential melanoma therapeutics.
European journal of medicinal chemistry 2011;46(8):3331-8.
2011: Arun K Sharma; Christina L Kline; Shantu Amin; Arthur Berg; Rosalyn B Irby
The Akt inhibitor ISC-4 activates prostate apoptosis response protein-4 and reduces colon tumor growth in a nude mouse model.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(13):4474-83.
2011: Gowdahalli Krishnegowda; Jacek Krzeminski; Jyh-Ming Lin; Arun K Sharma; Thomas E Spratt; Dhimant Desai; A S Prakasha Gowda; Shantu Amin
Facile syntheses of O(2)-[4-(3-pyridyl-4-oxobut-1-yl]thymidine, the major adduct formed by tobacco specific nitrosamine 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in vivo, and its site-specifically adducted oligodeoxynucleotides.
Chemical research in toxicology 2011;24(6):960-7.
2011: Chin-Ying Chung; Subbarao V Madhunapantula; Dhimant Desai; Shantu Amin; Gavin P. Robertson
Melanoma prevention using topical PBISe.
Cancer prevention research (Philadelphia, Pa.) 2011;4(6):935-48.
2011: Rebecca Guza; Robert H E Hudson; Ryszard Jankowiak; Roger Jones; Delshanee Kotandeniya; Rahul R Lad; Chen Lin; Kristopher Murphy; Shana J Sturla; Shantu Amin; Thakshila Dissanayake; George Madalin Giambasu; Filip Wojciechowski; Darrin M York; Natalia Tretyakova
Influence of C-5 substituted cytosine and related nucleoside analogs on the formation of benzo[a]pyrene diol epoxide-dG adducts at CG base pairs of DNA.
Nucleic acids research 2011;39(9):3988-4006.
2011: Ryan T Bushey; Gang Chen; Andrea S Blevins-Primeau; Jacek Krzeminski; Shantu Amin; Philip Lazarus
Characterization of UDP-glucuronosyltransferase 2A1 (UGT2A1) variants and their potential role in tobacco carcinogenesis.
Pharmacogenetics and genomics 2011;21(2):55-65.
2011: Natalie Nguyen; Arati Sharma; Nhung Nguyen; Arun K Sharma; Dhimant Desai; Sung Jin Huh; Shantu Amin; Craig Meyers; Gavin P. Robertson
Melanoma chemoprevention in skin reconstructs and mouse xenografts using isoselenocyanate-4.
Cancer prevention research (Philadelphia, Pa.) 2011;4(2):248-58.
2011: Jacek Krzeminski; Konstantin Kropachev; Marina Kolbanovskiy; Dara Reeves; Alexander Kolbanovskiy; Byeong Hwa Yun; Nicholas E Geacintov; Shantu Amin; Karam El-Bayoumy
Inefficient nucleotide excision repair in human cell extracts of the N-(deoxyguanosin-8-yl)-6-aminochrysene and 5-(deoxyguanosin-N(2)-yl)-6-aminochrysene adducts derived from 6-nitrochrysene.
Chemical research in toxicology 2011;24(1):65-72.
2010: Jeremy A Hengst; Xujun Wang; Ugir H Sk; Arun K Sharma; Shantu Amin; Jong K Yun
Development of a sphingosine kinase 1 specific small-molecule inhibitor.
Bioorganic & medicinal chemistry letters 2010;20(24):7498-502.
2010: Dhimant Desai; Naveen Kaushal; Ujjawal H Gandhi; Ryan J Arner; Christopher D'Souza; Gang Chen; Hema Vunta; Karam El-Bayoumy; Shantu Amin; K Sandeep Prabhu
Synthesis and evaluation of the anti-inflammatory properties of selenium-derivatives of celecoxib.
Chemico-biological interactions 2010;188(3):446-56.
2010: Nilkamal Karelia; Dhimant Desai; Jeremy A Hengst; Shantu Amin; Sairam V Rudrabhatla; Jong Yun
Selenium-containing analogs of SAHA induce cytotoxicity in lung cancer cells.
Bioorganic & medicinal chemistry letters 2010;20(22):6816-9.
2010: Ignazio Garaguso; Roman Halter; Jacek Krzeminski; Shantu Amin; Jürgen Borlak
Method for the rapid detection and molecular characterization of DNA alkylating agents by MALDI-TOF mass spectrometry.
Analytical chemistry 2010;82(20):8573-82.
2010: Qing Zhong; Shantu Amin; Philip Lazarus; Thomas E Spratt
Differential repair of polycyclic aromatic hydrocarbon DNA adducts from an actively transcribed gene.
DNA repair 2010;9(9):1011-6.
2010: Arun K Sharma; Ugir Hossain Sk; Melissa A Gimbor; Jeremy A Hengst; Xujun Wang; Jong Yun; Shantu Amin
Synthesis and bioactivity of sphingosine kinase inhibitors and their novel aspirinyl conjugated analogs.
European journal of medicinal chemistry 2010;45(9):4149-56.
2010: Prajakta S Palkar; Michael G Borland; Simone Naruhn; Christina H Ferry; Christina Lee; Ugir H Sk; Arun K Sharma; Shantu Amin; Iain A Murray; Cherie R Anderson; Gary H Perdew; Frank J Gonzalez; Rolf Müller; Jeffrey M Peters
Cellular and pharmacological selectivity of the peroxisome proliferator-activated receptor-beta/delta antagonist GSK3787.
Molecular pharmacology 2010;78(3):419-30.
2010: Oliver R Mikse; Daniel C Blake; Nathan R Jones; Yuan-Wan Sun; Shantu Amin; Carla J Gallagher; Philip Lazarus; Judith Weisz; Christopher R Herzog
FOXO3 encodes a carcinogen-activated transcription factor frequently deleted in early-stage lung adenocarcinoma.
Cancer research 2010;70(15):6205-15.
2010: Arun K Sharma; Ugir Hossain Sk; Pengfei He; Jeffrey M Peters; Shantu Amin
Synthesis of isosteric selenium analog of the PPARbeta/delta agonist GW501516 and comparison of biological activity.
Bioorganic & medicinal chemistry letters 2010;20(14):4050-2.
2010: Dhimant Desai; Indu Sinha; Kevin Null; William Wolter; Mark A Suckow; Tonya King; Shantu Amin; Raghu Sinha
Synthesis and antitumor properties of selenocoxib-1 against rat prostate adenocarcinoma cells.
International journal of cancer. Journal international du cancer 2010;127(1):230-8.
2010: Yuqin Cai; Konstantin Kropachev; Rong Xu; Yijin Tang; Marina Kolbanovskii; Alexander Kolbanovskii; Shantu Amin; Dinshaw J Patel; Suse Broyde; Nicholas E Geacintov
Distant neighbor base sequence context effects in human nucleotide excision repair of a benzo[a]pyrene-derived DNA lesion.
Journal of molecular biology 2010;399(3):397-409.
2010: Iain A Murray; Gowdahalli Krishnegowda; Brett C DiNatale; Colin Flaveny; Chris Chiaro; Jyh-Ming Lin; Arun K Sharma; Shantu Amin; Gary H Perdew
Development of a selective modulator of aryl hydrocarbon (Ah) receptor activity that exhibits anti-inflammatory properties.
Chemical research in toxicology 2010;23(5):955-66.
2010: Sans W Emmert; Dhimant Desai; Shantu Amin; John P Richie
Enhanced Nrf2-dependent induction of glutathione in mouse embryonic fibroblasts by isoselenocyanate analog of sulforaphane.
Bioorganic & medicinal chemistry letters 2010;20(8):2675-9.
2010: Dhimant Desai; Ugur Salli; Kent E Vrana; Shantu Amin
SelSA, selenium analogs of SAHA as potent histone deacetylase inhibitors.
Bioorganic & medicinal chemistry letters 2010;20(6):2044-7.
2010: Dhimant Desai; Subbarao V Madhunapantula; Krishnegowda Gowdahalli; Arati Sharma; Raghavendragowda Chandagaludoreswamy; Karam El-Bayoumy; Gavin P Robertson; Shantu Amin
Synthesis and characterization of a novel iNOS/Akt inhibitor Se,Se'-1,4-phenylenebis(1,2-ethanediyl)bisisoselenourea (PBISe)--against colon cancer.
Bioorganic & medicinal chemistry letters 2010;20(6):2038-43.
2010: Jennifer E Foreman; Arun K Sharma; Shantu Amin; Frank J Gonzalez; Jeffrey M Peters
Ligand activation of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) inhibits cell growth in a mouse mammary gland cancer cell line.
Cancer letters 2010;288(2):219-25.
2010: Wenjing Luo; Jingxia Li; Dongyun Zhang; T Cai; Lun Song; Xiao-Ming Yin; Dhimant Desai; Shantu Amin; Jingyuan Chen; Chuanshu Huang
Bid mediates anti-apoptotic COX-2 induction through the IKKbeta/NFkappaB pathway due to 5-MCDE exposure.
Current cancer drug targets 2010;10(1):96-106.
2010: Iain A Murray; Jose L Morales; Colin A Flaveny; Brett C Dinatale; Chris Chiaro; Krishnegowda Gowdahalli; Shantu Amin; Gary H Perdew
Evidence for ligand-mediated selective modulation of aryl hydrocarbon receptor activity.
Molecular pharmacology 2010;77(2):247-54.
2010: Jennifer C Schroeder; Brett C Dinatale; Iain A Murray; Colin A Flaveny; Qiang Liu; Elizabeth M Laurenzana; Jyh Ming Lin; Stephen C Strom; Curtis J Omiecinski; Shantu Amin; Gary H Perdew
The uremic toxin 3-indoxyl sulfate is a potent endogenous agonist for the human aryl hydrocarbon receptor.
Biochemistry 2010;49(2):393-400.
2009: Yuan-Wan Sun; Joseph B Guttenplan; Michael Khmelnitsky; Jacek Krzeminski; Telih Boyiri; Shantu Amin; Karam El-Bayoumy
Stereoselective metabolism of the environmental mammary carcinogen 6-nitrochrysene to trans-1,2-dihydroxy-1,2-dihydro-6-nitrochrysene by aroclor 1254-treated rat liver microsomes and their comparative mutation profiles in a laci mammary epithelial cell line.
Chemical research in toxicology 2009;22(12):1992-7.
2009: Kristine C Olson; Ryan W Dellinger; Qing Zhong; Dongxiao Sun; Shantu Amin; Thomas E Spratt; Philip Lazarus
Functional characterization of low-prevalence missense polymorphisms in the UDP-glucuronosyltransferase 1A9 gene.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(10):1999-2007.
2009: Arunangshu Das; James Bortner; Dhimant Desai; Shantu Amin; Karam El-Bayoumy
The selenium analog of the chemopreventive compound S,S'-(1,4-phenylenebis[1,2-ethanediyl])bisisothiourea is a remarkable inducer of apoptosis and inhibitor of cell growth in human non-small cell lung cancer.
Chemico-biological interactions 2009;180(2):158-64.
2009: Dong Xiao; Anna A Powolny; Jedrzej Antosiewicz; Eun-Ryeong Hahm; Ajay Bommareddy; Yan Zeng; Dhimant Desai; Shantu Amin; Anna Herman-Antosiewicz; Shivendra V Singh
Cellular responses to cancer chemopreventive agent D,L-sulforaphane in human prostate cancer cells are initiated by mitochondrial reactive oxygen species.
Pharmaceutical research 2009;26(7):1729-38.
2009: Kun-Ming Chen; Peter G Sacks; Thomas E Spratt; Jyh-Ming Lin; Telih Boyiri; Joel L. Schwartz; John P Richie; Ana Calcagnotto; Arunangshu Das; James Bortner; Zonglin Zhao; Shantu Amin; Joseph Guttenplan; Karam El-Bayoumy
Modulations of benzo[a]pyrene-induced DNA adduct, cyclin D1 and PCNA in oral tissue by 1,4-phenylenebis(methylene)selenocyanate.
Biochemical and biophysical research communications 2009;383(1):151-5.
2009: Konstantin Kropachev; Marina Kolbanovskii; Yuqin Cai; Fabian Rodríguez; Alexander Kolbanovskii; Yang Liu; Lu Zhang; Shantu Amin; Dinshaw J Patel; Suse Broyde; Nicholas E Geacintov
The sequence dependence of human nucleotide excision repair efficiencies of benzo[a]pyrene-derived DNA lesions: insights into the structural factors that favor dual incisions.
Journal of molecular biology 2009;386(5):1193-203.
2009: Andrea S Blevins-Primeau; Dongxiao Sun; Gang Chen; Arun K Sharma; Carla J Gallagher; Shantu Amin; Philip Lazarus
Functional significance of UDP-glucuronosyltransferase variants in the metabolism of active tamoxifen metabolites.
Cancer research 2009;69(5):1892-900.
2009: Shivendra V Singh; Renaud Warin; Dong Xiao; Anna A Powolny; Silvia D Stan; Julie A Arlotti; Yan Zeng; Eun-Ryeong Hahm; Stanley W Marynowski; Ajay Bommareddy; Dhimant Desai; Shantu Amin; Robert A Parise; Jan H Beumer; William Chambers
Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in TRAMP mice in association with increased cytotoxicity of natural killer cells.
Cancer research 2009;69(5):2117-25.
2009: Arati Sharma; Arun K Sharma; Subbarao V Madhunapantula; Dhimant Desai; Sung Jin Huh; Paul Mosca; Shantu Amin; Gavin P. Robertson
Targeting Akt3 signaling in malignant melanoma using isoselenocyanates.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(5):1674-85.
2008: Sarfaraz Ahmad; Sandra L Kabler; Lisa Rudd; Shantu Amin; Johannes Doehmer; Charles S Morrow; Alan J Townsend
Cytotoxicity and mutagenicity of 5-methylchrysene and its 1,2-dihydrodiol in V79MZ cells modified to express human CYP1A1 or CYP1B1, in the presence or absence of human GSTP1 coexpression.
Toxicology letters 2008;183(1-3):99-104.
2008: Pengfei He; Michael G Borland; Bokai Zhu; Arun K Sharma; Shantu Amin; Karam El-Bayoumy; Frank J Gonzalez; Jeffrey M Peters
Effect of ligand activation of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) in human lung cancer cell lines.
Toxicology 2008;254(1-2):112-7.
2008: Michael G Borland; Jennifer E Foreman; Elizabeth E Girroir; Reza Zolfaghari; Arun K Sharma; Shantu Amin; Frank J Gonzalez; A Catharine Ross; Jeffrey M Peters
Ligand activation of peroxisome proliferator-activated receptor-beta/delta inhibits cell proliferation in human HaCaT keratinocytes.
Molecular pharmacology 2008;74(5):1429-42.
2008: Subbarao V Madhunapantula; Dhimant Desai; Arati Sharma; Sung Jin Huh; Shantu Amin; Gavin P. Robertson
PBISe, a novel selenium-containing drug for the treatment of malignant melanoma.
Molecular cancer therapeutics 2008;7(5):1297-308.
2008: Arun K Sharma; Krishnegowda Gowdahalli; Melissa Gimbor; Shantu Amin
Synthesis, microsome-mediated metabolism, and identification of major metabolites of environmental pollutant naphtho[8,1,2-ghi]chrysene.
Chemical research in toxicology 2008;21(5):1154-62.
2008: José Luis Morales; Jacek Krzeminski; Shantu Amin; Gary H Perdew
Characterization of the antiallergic drugs 3-[2-(2-phenylethyl) benzoimidazole-4-yl]-3-hydroxypropanoic acid and ethyl 3-hydroxy-3-[2-(2-phenylethyl)benzoimidazol-4-yl]propanoate as full aryl hydrocarbon receptor agonists.
Chemical research in toxicology 2008;21(2):472-82.
2008: Elizabeth E Girroir; Holly E Hollingshead; Andrew N Billin; Timothy M Willson; Gavin P. Robertson; Arun K Sharma; Shantu Amin; Frank J Gonzalez; Jeffrey M Peters
Peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) ligands inhibit growth of UACC903 and MCF7 human cancer cell lines.
Toxicology 2008;243(1-2):236-43.
2007: Joseph B Guttenplan; Kun-Ming Chen; Michael Khmelnitsky; Wieslawa Kosinska; Jeannie Hennessy; Richard Bruggeman; Dhimant Desai; Shantu Amin; Yuan-Wan Sun; Thomas E Spratt; Karam El-Bayoumy
Effects of 1,4-phenylenebis(methylene)selenocyanate on mutagenesis and p53 protein expression in the tongue of lacI rats treated with 4-nitroquinoline-N-oxide.
Mutation research 2007;634(1-2):146-55.
2007: Holly E Hollingshead; Renee L Killins; Michael G Borland; Elizabeth E Girroir; Andrew N Billin; Timothy M Willson; Arun K Sharma; Shantu Amin; Frank J Gonzalez; Jeffrey M Peters
Peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) ligands do not potentiate growth of human cancer cell lines.
Carcinogenesis 2007;28(12):2641-9.
2007: Arun K Sharma; Krishnegowda Gowdahalli; Jacek Krzeminski; Shantu Amin
Microwave-assisted Suzuki cross-coupling reaction, a key step in the synthesis of polycyclic aromatic hydrocarbons and their metabolites.
The Journal of organic chemistry 2007;72(23):8987-9.
2007: Kun-Ming Chen; Thomas E Spratt; Bruce Stanley; Dan A De Cotiis; Maria C Bewley; John M Flanagan; Dhimant Desai; Arunangshu Das; Emerich Fiala; Shantu Amin; Karam El-Bayoumy
Inhibition of nuclear factor-kappaB DNA binding by organoselenocyanates through covalent modification of the p50 subunit.
Cancer research 2007;67(21):10475-83.
2007: Dongxiao Sun; Arun K Sharma; Ryan W Dellinger; Andrea S Blevins-Primeau; Renee M Balliet; Gang Chen; Telih Boyiri; Shantu Amin; Philip Lazarus
Glucuronidation of active tamoxifen metabolites by the human UDP glucuronosyltransferases.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(11):2006-14.
2007: Ryan W Dellinger; Gang Chen; Andrea S Blevins-Primeau; Jacek Krzeminski; Shantu Amin; Philip Lazarus
Glucuronidation of PhIP and N-OH-PhIP by UDP-glucuronosyltransferase 1A10.
Carcinogenesis 2007;28(11):2412-8.
2007: Joseph B Guttenplan; Zhong-lin Zhao; Wieslawa Kosinska; Robert Norman; Jacek Krzeminski; Yuan-Wan Sun; Shantu Amin; Karam El-Bayoumy
Comparative mutational profiles of the environmental mammary carcinogen, 6-nitrochrysene and its metabolites in a lacI mammary epithelial cell line.
Carcinogenesis 2007;28(11):2391-7.
2007: Yuan-Wan Sun; Christopher R Herzog; Jacek Krzeminski; Shantu Amin; Gary Perdew; Karam El-Bayoumy
Effects of the environmental mammary carcinogen 6-nitrochrysene on p53 and p21(Cip1) protein expression and cell cycle regulation in MCF-7 and MCF-10A cells.
Chemico-biological interactions 2007;170(1):31-9.
2007: Yan Zheng; Dongxiao Sun; Arun K Sharma; Gang Chen; Shantu Amin; Philip Lazarus
Elimination of antiestrogenic effects of active tamoxifen metabolites by glucuronidation.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(10):1942-8.
2007: Weiming Ouyang; Yu Hu; Jingxia Li; Min Ding; Yongju Lu; Dongyun Zhang; Yan Yan; Lun Song; Qingshan Qu; Dhimant Desai; Shantu Amin; Chuanshu Huang
Direct evidence for the critical role of NFAT3 in benzo[a]pyrene diol-epoxide-induced cell transformation through mediation of inflammatory cytokine TNF induction in mouse epidermal Cl41 cells.
Carcinogenesis 2007;28(10):2218-26.
2007: Qian Ruan; Tongming Liu; Alexander Kolbanovskiy; Yang Liu; Jian Ren; Milan Skorvaga; Yue Zou; Joshua Lader; Brijesh Malkani; Shantu Amin; Bennett Van Houten; Nicholas E Geacintov
Sequence context- and temperature-dependent nucleotide excision repair of a benzo[a]pyrene diol epoxide-guanine DNA adduct catalyzed by thermophilic UvrABC proteins.
Biochemistry 2007;46(23):7006-15.
2007: Carol S Trempus; Rebecca J Morris; Matthew Ehinger; Amy Elmore; Carl Bortner; Mayumi Ito; George Cotsarelis; Joanne G W Nijhof; John Peckham; Norris Flagler; Grace E Kissling; Margaret M Humble; Leon C King; Linda D Adams; Dhimant Desai; Shantu Amin; Raymond W Tennant
CD34 expression by hair follicle stem cells is required for skin tumor development in mice.
Cancer research 2007;67(9):4173-81.
2007: Garret Nelson; Jeffrey Ross; Maria Pimentel; Dhimant Desai; Arun K Sharma; Shantu Amin; Stephen Nesnow
Characterization of naphtho[1,2-a]pyrene and naphtho[1,2-e]pyrene DNA adducts in C3H10T1/2 fibroblasts.
Cancer letters 2007;247(2):309-17.
2007: Fabián A Rodríguez; Yuqin Cai; Chin Lin; Yijin Tang; Alexander Kolbanovskiy; Shantu Amin; Dinshaw J Patel; Suse Broyde; Nicholas E Geacintov
Exocyclic amino groups of flanking guanines govern sequence-dependent adduct conformations and local structural distortions for minor groove-aligned benzo[a]pyrenyl-guanine lesions in a GG mutation hotspot context.
Nucleic acids research 2007;35(5):1555-68.
2006: Brinda Mahadevan; Andreas Luch; Jennifer Atkin; Tuan Nguyen; Arun K Sharma; Shantu Amin; William M Baird
Investigation of the genotoxicity of dibenzo[c,p]chrysene in human carcinoma MCF-7 cells in culture.
Chemico-biological interactions 2006;164(3):181-91.
2006: Arati Sharma; Melissa A Tran; Shile Liang; Arun K Sharma; Shantu Amin; Charles D. Smith; Cheng Dong; Gavin P. Robertson
Targeting mitogen-activated protein kinase/extracellular signal-regulated kinase kinase in the mutant (V600E) B-Raf signaling cascade effectively inhibits melanoma lung metastases.
Cancer research 2006;66(16):8200-9.
2006: Karam El-Bayoumy; Arunangshu Das; Bhagavathi A Narayanan; Narayanan Narayanan; Emerich Fiala; Dhimant Desai; Chinthalapally V Rao; Shantu Amin; Raghu Sinha
Molecular targets of the chemopreventive agent 1,4-phenylenebis (methylene)-selenocyanate in human non-small cell lung cancer.
Carcinogenesis 2006;27(7):1369-76.
2006: Jin Ding; Jingxia Li; Jingyuan Chen; Haobin Chen; Weiming Ouyang; Ronghe Zhang; Caifang Xue; Dongyun Zhang; Shantu Amin; Dhimant Desai; Chuanshu Huang
Effects of polycyclic aromatic hydrocarbons (PAHs) on vascular endothelial growth factor induction through phosphatidylinositol 3-kinase/AP-1-dependent, HIF-1alpha-independent pathway.
The Journal of biological chemistry 2006;281(14):9093-100.
2006: Christopher R Herzog; Dhimant Desai; Shantu Amin
Array CGH analysis reveals chromosomal aberrations in mouse lung adenocarcinomas induced by the human lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Biochemical and biophysical research communications 2006;341(3):856-63.
2006: Jishen Pan; Warren Davis; Neil Trushin; Shantu Amin; Raghu G Nath; Norman Salem; Fung-Lung Chung
A solid-phase extraction/high-performance liquid chromatography-based (32)P-postlabeling method for detection of cyclic 1,N(2)-propanodeoxyguanosine adducts derived from enals.
Analytical biochemistry 2006;348(1):15-23.
2005: Arun K Sharma; Shantu Amin
Synthesis and identification of major metabolites of environmental pollutant dibenzo[c,mno]chrysene.
Chemical research in toxicology 2005;18(9):1438-43.
2005: Arun K Sharma; Jyh-Ming Lin; Dhimant Desai; Shantu Amin
Convenient syntheses of dibenzo[c,p]chrysene and its possible proximate and ultimate carcinogens: in vitro metabolism and DNA adduction studies.
The Journal of organic chemistry 2005;70(13):4962-70.
2005: Na Zhang; Chin Lin; Xuanwei Huang; Alexander Kolbanovskiy; Brian E Hingerty; Shantu Amin; Suse Broyde; Nicholas E Geacintov; Dinshaw J Patel
Methylation of cytosine at C5 in a CpG sequence context causes a conformational switch of a benzo[a]pyrene diol epoxide-N2-guanine adduct in DNA from a minor groove alignment to intercalation with base displacement.
Journal of molecular biology 2005;346(4):951-65.
2005: Louisa A Hooven; Brinda Mahadevan; Channa Keshava; Christopher Johns; Cliff Pereira; Dhimant Desai; Shantu Amin; Ainsley Weston; William M Baird
Effects of suberoylanilide hydroxamic acid and trichostatin A on induction of cytochrome P450 enzymes and benzo[a]pyrene DNA adduct formation in human cells.
Bioorganic & medicinal chemistry letters 2005;15(5):1283-7.
2005: Fung-Lung Chung; Despina Komninou; Lei Zhang; Raghu Nath; Jishen Pan; Shantu Amin; John Richie
Glutathione depletion enhances the formation of endogenous cyclic DNA adducts derived from t-4-hydroxy-2-nonenal in rat liver.
Chemical research in toxicology 2005;18(1):24-7.
2004: Karam El-Bayoumy; Arun K Sharma; Jyh-Ming Lin; Jacek Krzeminski; Telih Boyiri; Leon C King; Guy Lambert; William T Padgett; Stephen Nesnow; Shantu Amin
Identification of 5-(deoxyguanosin-N2-yl)- 1,2-dihydroxy-1,2-dihydro-6-aminochrysene as the major DNA lesion in the mammary gland of rats treated with the environmental pollutant 6-nitrochrysene.
Chemical research in toxicology 2004;17(12):1591-9.
2004: Jung-Hoon Yoon; Ahmad Besaratinia; Zhaohui Feng; Moon-shong Tang; Shantu Amin; Andreas Luch; Gerd P Pfeifer
DNA damage, repair, and mutation induction by (+)-Syn and (-)-anti-dibenzo[a,l]pyrene-11,12-diol-13,14-epoxides in mouse cells.
Cancer research 2004;64(20):7321-8.
2004: Shivendra V Singh; Vijayalakshmi Varma; Piotr Zimniak; Sanjay Srivastava; Stanley W Marynowski; Dhimant Desai; Shantu Amin; Xinhua Ji
Structural basis for catalytic differences between alpha class human glutathione transferases hGSTA1-1 and hGSTA2-2 for glutathione conjugation of environmental carcinogen benzo[a]pyrene-7,8-diol-9,10-epoxide.
Biochemistry 2004;43(30):9708-15.
2004: Yuan-Wan Sun; F Peter Guengerich; Arun K Sharma; Telih Boyiri; Shantu Amin; Karam El-Bayoumy
Human cytochromes P450 1A1 and 1B1 catalyze ring oxidation but not nitroreduction of environmental pollutant mononitropyrene isomers in primary cultures of human breast cells and cultured MCF-10A and MCF-7 cell lines.
Chemical research in toxicology 2004;17(8):1077-85.
2004: Joel L. Schwartz; Vikki Baker; Eric Larios; Dhimant Desai; Shantu Amin
Inhibition of experimental tobacco carcinogen induced head and neck carcinogenesis.
Oral oncology 2004;40(6):611-23.
2004: Sujata Choudhury; Jishen Pan; Shantu Amin; Fung-Lung Chung; Rabindra Roy
Repair kinetics of trans-4-hydroxynonenal-induced cyclic 1,N2-propanodeoxyguanine DNA adducts by human cell nuclear extracts.
Biochemistry 2004;43(23):7514-21.
2004: Jingxia Li; Haobin Chen; Qingdong Ke; Zhaohui Feng; Moon-shong Tang; Bingci Liu; Shantu Amin; Max Costa; Chuanshu Huang
Differential effects of polycyclic aromatic hydrocarbons on transactivation of AP-1 and NF-kappaB in mouse epidermal cl41 cells.
Molecular carcinogenesis 2004;40(2):104-15.
2004: Arun K Sharma; Subodh Kumar; Shantu Amin
A Highly Abbreviated Synthesis of Dibenzo[def,p]chrysene and Its 12-Methoxy Derivative, a Key Precursor for the Synthesis of the Proximate and Ultimate Carcinogens of Dibenzo[def,p]chrysene.
The Journal of organic chemistry 2004;69(11):3979-82.
2004: Jingxia Li; Haobin Chen; Moon-shong Tang; Xianglin Shi; Shantu Amin; Dhimant Desai; Max Costa; Chuanshu Huang
PI-3K and Akt are mediators of AP-1 induction by 5-MCDE in mouse epidermal Cl41 cells.
The Journal of cell biology 2004;165(1):77-86.
2004: Telih Boyiri; Joseph B Guttenplan; Michael Khmelnitsky; Wieslawa Kosinska; Jyh-Ming Lin; Dhimant Desai; Shantu Amin; Brian Pittman; Karam El-Bayoumy
Mammary carcinogenesis and molecular analysis of in vivo cII gene mutations in the mammary tissue of female transgenic rats treated with the environmental pollutant 6-nitrochrysene.
Carcinogenesis 2004;25(4):637-43.
2004: Subodh Kumar; Jyh Ming Lin; John Whysner; Harish C Sikka; Shantu Amin
Mutagenicity of benzo[b]phenanthro[2,3-d]thiophene (BPT) and its metabolites in TA100 and base-specific tester strains (TA7001-TA7006) of Salmonella typhimurium: evidence of multiple pathways for the bioactivation of BPT.
Mutation research 2004;545(1-2):11-21.
2004: Brinda Mahadevan; Heather Parsons; Tamara Musafia; Arun K Sharma; Shantu Amin; Cliff Pereira; William M Baird
Effect of artificial mixtures of environmental polycyclic aromatic hydrocarbons present in coal tar, urban dust, and diesel exhaust particulates on MCF-7 cells in culture.
Environmental and molecular mutagenesis 2004;44(2):99-107.
2003: Karam El-Bayoumy; Arunangshu Das; Telih Boyiri; Dhimant Desai; Raghu Sinha; Brian Pittman; Shantu Amin
Comparative action of 1,4-phenylenebis(methylene)selenocyanate and its metabolites against 7,12-dimethylbenz[a]anthracene-DNA adduct formation in the rat and cell proliferation in rat mammary tumor cells.
Chemico-biological interactions 2003;146(2):179-90.
2003: Zhaohui Feng; Wenwei Hu; Shantu Amin; Moon-shong Tang
Mutational spectrum and genotoxicity of the major lipid peroxidation product, trans-4-hydroxy-2-nonenal, induced DNA adducts in nucleotide excision repair-proficient and -deficient human cells.
Biochemistry 2003;42(25):7848-54.
2003: Nancy W Shappell; Uli Carlino-MacDonald; Shantu Amin; Subodh Kumar; Harish C Sikka
Comparative metabolism of chrysene and 5-methylchrysene by rat and rainbow trout liver microsomes.
Toxicological sciences : an official journal of the Society of Toxicology 2003;72(2):260-6.
2003: Xuanwei Huang; Alexander Kolbanovskiy; Xiaohua Wu; Yanbin Zhang; Zhigang Wang; Ping Zhuang; Shantu Amin; Nicholas E Geacintov
Effects of base sequence context on translesion synthesis past a bulky (+)-trans-anti-B[a]P-N2-dG lesion catalyzed by the Y-family polymerase pol kappa.
Biochemistry 2003;42(8):2456-66.
2003: Shantu Amin; Jyh-Ming Lin; Jacek Krzeminski; Telih Boyiri; Dhimant Desai; Karam El-Bayoumy
Metabolism of benzo[c]chrysene and comparative mammary gland tumorigenesis of benzo[c]chrysene bay and fjord region diol epoxides in female CD rats.
Chemical research in toxicology 2003;16(2):227-31.
2003: Arunangshu Das; Dhimant Desai; Brian Pittman; Shantu Amin; Karam El-Bayoumy
Comparison of the chemopreventive efficacies of 1,4-phenylenebis(methylene)selenocyanate and selenium-enriched yeast on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced lung tumorigenesis in A/J mouse.
Nutrition and cancer 2003;46(2):179-85.
2003: Dhimant Desai; Arunangshu Das; Leonard Cohen; Karam El-Bayoumy; Shantu Amin
Chemopreventive efficacy of suberoylanilide hydroxamic acid (SAHA) against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in female A/J mice.
Anticancer research 2003;23(1A):499-503.
2002: Wenwei Hu; Zhaohui Feng; Jamie Eveleigh; Ganesh Iyer; Jishen Pan; Shantu Amin; Fung-Lung Chung; Moon-shong Tang
The major lipid peroxidation product, trans-4-hydroxy-2-nonenal, preferentially forms DNA adducts at codon 249 of human p53 gene, a unique mutational hotspot in hepatocellular carcinoma.
Carcinogenesis 2002;23(11):1781-9.
2002: Olga Rechkoblit; Yanbin Zhang; Dongyu Guo; Zhigang Wang; Shantu Amin; Jacek Krzeminsky; Natalia Louneva; Nicholas E Geacintov
trans-Lesion synthesis past bulky benzo[a]pyrene diol epoxide N2-dG and N6-dA lesions catalyzed by DNA bypass polymerases.
The Journal of biological chemistry 2002;277(34):30488-94.
2002: Telih Boyiri; Joanna Leszczynska; Dhimant Desai; Shantu Amin; Daniel W Nixon; Karam El-Bayoumy
Metabolism and DNA binding of the environmental pollutant 6-nitrochrysene in primary culture of human breast cells and in cultured MCF-10A, MCF-7 and MDA-MB-435s cell lines.
International journal of cancer. Journal international du cancer 2002;100(4):395-400.
2002: Karam El-Bayoumy; Dhimant Desai; Telih Boyiri; Jose Rosa; Jacek Krzeminski; Arun K Sharma; Brian Pittman; Shantu Amin
Comparative tumorigenicity of the environmental pollutant 6-nitrochrysene and its metabolites in the rat mammary gland.
Chemical research in toxicology 2002;15(7):972-8.
2002: Dhimant Desai; Arun K Sharma; Jyh-Ming Lin; Jacek Krzeminski; Maria Pimentel; Karam El-Bayoumy; Stephen Nesnow; Shantu Amin
Synthesis, in vitro metabolism, cell transformation, mutagenicity, and DNA adduction of dibenzo[c,mno]chrysene.
Chemical research in toxicology 2002;15(7):964-71.
2002: Leonard A Cohen; Paul A Marks; Richard A Rifkind; Shantu Amin; Dhimant Desai; Brian Pittman; Victoria M Richon
Suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, suppresses the growth of carcinogen-induced mammary tumors.
Anticancer research 2002;22(3):1497-504.
2002: Bogdan Prokopczyk; Dietrich Hoffmann; Matthew Bologna; A John Cunningham; Neil Trushin; Shobha Akerkar; Telih Boyiri; Shantu Amin; Dhimant Desai; Stephen Colosimo; Brian Pittman; Gerhard Leder; Marco Ramadani; Doris Henne-Bruns; Hans G Beger; Karam El-Bayoumy
Identification of tobacco-derived compounds in human pancreatic juice.
Chemical research in toxicology 2002;15(5):677-85.
2002: Xuanwei Huang; Katharine C Colgate; Alexander Kolbanovskiy; Shantu Amin; Nicholas E Geacintov
Conformational changes of a benzo[a]pyrene diol epoxide-N(2)-dG adduct induced by a 5'-flanking 5-methyl-substituted cytosine in a (Me)CG double-stranded oligonucleotide sequence context.
Chemical research in toxicology 2002;15(3):438-44.
2002: Qian Ruan; Alexander Kolbanovskiy; Ping Zhuang; Junxin Chen; Jacek Krzeminski; Shantu Amin; Nicholas E Geacintov
Synthesis and characterization of site-specific and stereoisomeric fjord dibenzo[a,l]pyrene diol epoxide-N(6)-adenine adducts: unusual thermal stabilization of modified DNA duplexes.
Chemical research in toxicology 2002;15(2):249-61.
2002: Weidong Huang; Shantu Amin; Nicholas E Geacintov
Fluorescence characteristics of site-specific and stereochemically distinct benzo[a]pyrene diol epoxide-DNA adducts as probes of adduct conformation.
Chemical research in toxicology 2002;15(2):118-26.
2002: Yang-Ming Yang; C Clifford Conaway; Jen Wei Chiao; Chung-Xiou Wang; Shantu Amin; John Whysner; Wei Dai; Joel Reinhardt; Fung-Lung Chung
Inhibition of benzo(a)pyrene-induced lung tumorigenesis in A/J mice by dietary N-acetylcysteine conjugates of benzyl and phenethyl isothiocyanates during the postinitiation phase is associated with activation of mitogen-activated protein kinases and p53 activity and induction of apoptosis.
Cancer research 2002;62(1):2-7.
2001: C Clifford Conaway; J Krzeminski; Shantu Amin; Fung-Lung Chung
Decomposition rates of isothiocyanate conjugates determine their activity as inhibitors of cytochrome p450 enzymes.
Chemical research in toxicology 2001;14(9):1170-6.
2001: Ping Zhuang; Alexander Kolbanovskiy; Shantu Amin; Nicholas E Geacintov
Base sequence dependence of in vitro translesional DNA replication past a bulky lesion catalyzed by the exo- Klenow fragment of Pol I.
Biochemistry 2001;40(22):6660-9.
2001: Leon C King; Michael J Kohan; L Brooks; Garret B Nelson; Jeffrey Ross; J Allison; L Adams; Dhimant Desai; Shantu Amin; William T Padgett; Guy Lambert; Ann M Richard; Stephen Nesnow
An evaluation of the mutagenicity, metabolism, and DNA adduct formation of 5-nitrobenzo[b]naphtho[2,1-d]thiophene.
Chemical research in toxicology 2001;14(6):661-71.
2001: Olga Rechkoblit; J Krzeminsky; Shantu Amin; B Jernström; Natalia Louneva; Nicholas E Geacintov
Influence of bulky polynuclear carcinogen lesions in a TATA promoter sequence on TATA binding protein-DNA complex formation.
Biochemistry 2001;40(19):5622-32.
2001: R B Roth; Shantu Amin; Nicholas E Geacintov; David A Scicchitano
Bacteriophage T7 RNA polymerase transcription elongation is inhibited by site-specific, stereospecific benzo[c]phenanthrene diol epoxide DNA lesions.
Biochemistry 2001;40(17):5200-7.
2001: C H Lin; X Huang; A Kolbanovskii; Brian E Hingerty; Shantu Amin; Suse Broyde; Nicholas E Geacintov; Dinshaw J Patel
Molecular topology of polycyclic aromatic carcinogens determines DNA adduct conformation: a link to tumorigenic activity.
Journal of molecular biology 2001;306(5):1059-80.
2000: Ajay Pal; D H Desai; Shantu Amin; S K Srivastava; X Hu; C Herzog; Piotr Zimniak; Shivendra V Singh
Location of the epoxide function determines specificity of the allelic variants of human glutathione transferase Pi toward benzo[c]chrysene diol epoxide isomers.
FEBS letters 2000;486(2):163-6.
2000: Bogdan Prokopczyk; JG Rosa; Dhimant Desai; Shantu Amin; Ock Soon Sohn; Emerich Fiala; Karam El-Bayoumy
Chemoprevention of lung tumorigenesis induced by a mixture of benzo(a)pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by the organoselenium compound 1,4-phenylenebis(methylene)selenocyanate.
Cancer letters 2000;161(1):35-46.
2000: Jacek Krzeminski; Dhimant Desai; Jyh-Ming Lin; Vladimir Serebryany; Karam El-Bayoumy; Shantu Amin
Synthesis of anti-1,2-dihydroxy-3,4-epoxy-1,2,3, 4-tetrahydro-6-nitrochrysene and its reaction with 2'-deoxyguanosine- 5'-monophosphate, 2'-deoxyadenosine-5'-monophosphate, and calf thymus DNA in vitro.
Chemical research in toxicology 2000;13(11):1143-8.
2000: S Shimotakahara; Andrey Gorin; Alexander Kolbanovskiy; A Kettani; Brian E Hingerty; Shantu Amin; Suse Broyde; Nicholas E Geacintov; Dinshaw J Patel
Accomodation of S-cis-tamoxifen-N(2)-guanine adduct within a bent and widened DNA minor groove.
Journal of molecular biology 2000;302(2):377-93.
2000: Jen Wei Chiao; F Chung; J Krzeminski; Shantu Amin; R Arshad; Tauseef Ahmed; C Clifford Conaway
Modulation of growth of human prostate cancer cells by the N-acetylcysteine conjugate of phenethyl isothiocyanate.
International journal of oncology 2000;16(6):1215-9.
2000: Smith Leslie; Mikhail F Denissenko; Patrick Williams; H Li; Shantu Amin; M Tang; Gerd P Pfeifer
Targeting of lung cancer mutational hotspots by polycyclic aromatic hydrocarbons.
Journal of the National Cancer Institute 2000;92(10):803-11.
2000: Karam El-Bayoumy; YH Chae; JG Rosa; L K Williams; Dhimant Desai; Shantu Amin; Emerich Fiala
The effects of 1-nitropyrene, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 7,12-dimethylbenz[a]anthracene on 8-hydroxy-2'-deoxyguanosine levels in the rat mammary gland and modulation by dietary 1,4-phenylenebis(methylene) selenocyanate.
Cancer letters 2000;151(1):7-13.
1999: Leonard A Cohen; Shantu Amin; Paul A Marks; Richard A Rifkind; Dhimant Desai; Victoria M Richon
Chemoprevention of carcinogen-induced mammary tumorigenesis by the hybrid polar cytodifferentiation agent, suberanilohydroxamic acid (SAHA).
Anticancer research 1999;19(6B):4999-5005.
1999: Leon C King; L Adams; J Allison; Michael J Kohan; G Nelson; Dhimant Desai; Shantu Amin; Jeffrey Ross
A quantitative comparison of dibenzo[a,l]pyrene-DNA adduct formation by recombinant human cytochrome P450 microsomes.
Molecular carcinogenesis 1999;26(2):74-82.
1999: AK Suri; B Mao; Shantu Amin; Nicholas E Geacintov; Dinshaw J Patel
Solution conformation of the (+)-trans-anti-benzo[g]chrysene-dA adduct opposite dT in a DNA duplex.
Journal of molecular biology 1999;292(2):289-307.
1999: Olga Rechkoblit; Shantu Amin; Nicholas E Geacintov
Primer length dependence of binding of DNA polymerase I Klenow fragment to template-primer complexes containing site-specific bulky lesions.
Biochemistry 1999;38(36):11834-43.
1999: B Mao; Xiaoling kang; Andrey Gorin; J Chen; Brian E Hingerty; Shantu Amin; Suse Broyde; Nicholas E Geacintov; Dinshaw J Patel
Solution structure of the (+)-cis-anti-benzo[a]pyrene-dA ([BP]dA) adduct opposite dT in a DNA duplex.
Biochemistry 1999;38(33):10831-42.
1999: Jyh-Ming Lin; Dhimant Desai; L Chung; Stephen S Hecht; Shantu Amin
Synthesis of anti-7,8-dihydroxy-9,10-epoxy-7,8,9, 10-tetrahydro-11-methylbenzo[a]pyrene and its reaction with DNA.
Chemical research in toxicology 1999;12(4):341-6.
1999: Karam El-Bayoumy; Michael J Iatropoulos; Shantu Amin; D Hoffmann; E L Wynder
Increased expression of cyclooxygenase-2 in rat lung tumors induced by the tobacco-specific nitrosamine 4-(methylnitrosamino)-4-(3-pyridyl)-1-butanone: the impact of a high-fat diet.
Cancer research 1999;59(7):1400-3.
1998: J Ni; T Liu; Alexander Kolbanovskiy; Jacek Krzeminski; Shantu Amin; Nicholas E Geacintov
Mass spectrometric sequencing of site-specific carcinogen-modified oligodeoxyribonucleotides containing bulky benzo[a]pyrene diol epoxide-deoxyguanosyl adducts.
Analytical biochemistry 1998;264(2):222-9.
1998: H Tsao; B Mao; Ping Zhuang; R Xu; Shantu Amin; Nicholas E Geacintov
Sequence dependence and characteristics of bends induced by site-specific polynuclear aromatic carcinogen-deoxyguanosine lesions in oligonucleotides.
Biochemistry 1998;37(14):4993-5000.
1998: N Pirogov; Vladimir Shafirovich; Alexander Kolbanovskiy; K Solntsev; S A Courtney; Shantu Amin; Nicholas E Geacintov
Role of hydrophobic effects in the reaction of a polynuclear aromatic diol epoxide with oligodeoxynucleotides in aqueous solutions.
Chemical research in toxicology 1998;11(4):381-8.
1998: R Xu; B Mao; Shantu Amin; Nicholas E Geacintov
Bending and circularization of site-specific and stereoisomeric carcinogen-DNA adducts.
Biochemistry 1998;37(2):769-78.
1997: D Jiao; T J Smith; C S Yang; Brian Pittman; D Desai; Shantu Amin; Fung-Lung Chung
Chemopreventive activity of thiol conjugates of isothiocyanates for lung tumorigenesis.
Carcinogenesis 1997;18(11):2143-7.
1997: Bogdan Prokopczyk; Shantu Amin; Dhimant Desai; C Kurtzke; P Upadhyaya; Karam El-Bayoumy
Effects of 1,4-phenylenebis(methylene)selenocyanate and selenomethionine on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced tumorigenesis in A/J mouse lung.
Carcinogenesis 1997;18(9):1855-7.
1997: Nicholas E Geacintov; Monique Cosman; Brian E Hingerty; Shantu Amin; Suse Broyde; Dinshaw J Patel
NMR solution structures of stereoisometric covalent polycyclic aromatic carcinogen-DNA adduct: principles, patterns, and diversity.
Chemical research in toxicology 1997;10(2):111-46.
1996: Stephen S Hecht; Abraham Rivenson; Shantu Amin; J Krzeminski; Karam El-Bayoumy; Bandaru S Reddy; C Kurtzke; E J La Voie
Mammary carcinogenicity of diol epoxide metabolites of benzo[j]fluoranthene in female CD rats.
Cancer letters 1996;106(2):251-5.
1996: Karam El-Bayoumy; P Upadhyaya; Dhimant Desai; Shantu Amin; D Hoffmann; E L Wynder
Effects of 1,4-phenylenebis(methylene)selenocyanate, phenethyl isothiocyanate, indole-3-carbinol, and d-limonene individually and in combination on the tumorigenicity of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung.
Anticancer research 1996;16(5A):2709-12.
1996: Stephen S Hecht; N Trushin; J Rigotty; Steven G Carmella; A Borukhova; SA Akerkar; D Desai; Shantu Amin; Abraham Rivenson
Inhibitory effects of 6-phenylhexyl isothiocyanate on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolic activation and lung tumorigenesis in rats.
Carcinogenesis 1996;17(9):2061-7.
1996: R Xu; S Dwarakanath; M Cosman; Shantu Amin; Nicholas E Geacintov
Site-specific adducts derived from the binding of anti-5-methylchrysene diol epoxide enantiomers to DNA: synthesis and characteristics.
Carcinogenesis 1996;17(9):2035-42.
1996: M Cosman; Brian E Hingerty; N Luneva; Shantu Amin; Nicholas E Geacintov; Suse Broyde; Dinshaw J Patel
Solution conformation of the (-)-cis-anti-benzo[a]pyrenyl-dG adduct opposite dC in a DNA duplex: intercalation of the covalently attached BP ring into the helix with base displacement of the modified deoxyguanosine into the major groove.
Biochemistry 1996;35(30):9850-63.
1996: Ze'ev Ronai; A Polotskaya; S Gradia; Shantu Amin; Stephen S Hecht
Expression of a 32 kDa protein in rat mammary tumors induced by anti-benzo[c]phenanthrene-3,4-diol-1,2-epoxide.
International journal of cancer. Journal international du cancer 1996;67(1):124-8.
1996: Karam El-Bayoumy; B Y Ji; P Upadhyaya; YH Chae; C Kurtzke; Abraham Rivenson; Bandaru S Reddy; Shantu Amin; Stephen S Hecht
Lack of tumorigenicity of cholesterol epoxides and estrone-3,4-quinone in the rat mammary gland.
Cancer research 1996;56(9):1970-3.
1996: D Jiao; T J Smith; S Kim; C S Yang; D Desai; Shantu Amin; Fung-Lung Chung
The essential role of the functional group in alkyl isothiocyanates for inhibition of tobacco nitrosamine-induced lung tumorigenesis.
Carcinogenesis 1996;17(4):755-9.
1996: Bogdan Prokopczyk; J E Cox; P Upadhyaya; Shantu Amin; D Desai; D Hoffmann; Karam El-Bayoumy
Effects of dietary 1,4-phenylenebis(methylene)selenocyanate on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA adduct formation in lung and liver of A/J mice and F344 rats.
Carcinogenesis 1996;17(4):749-53.
1996: Assieh A Melikian; P Sun; S Coleman; Shantu Amin; Stephen S Hecht
Detection of DNA and globin adducts of polynuclear aromatic hydrocarbon diol epoxides by gas chromatography-mass spectrometry and -3H-CH3I postlabeling of released tetraols.
Chemical research in toxicology 1996;9(2):508-16.
1996: W Koehl; Shantu Amin; M E Staretz; Y F Ueng; H Yamazaki; T Tateishi; F P Guengerich; Stephen S Hecht
Metabolism of 5-methylchrysene and 6-methylchrysene by human hepatic and pulmonary cytochrome P450 enzymes.
Cancer research 1996;56(2):316-24.
1996: T Liu; J Xu; H Tsao; B Li; R Xu; C Yang; Shantu Amin; M Moriya; Nicholas E Geacintov
Base sequence-dependent bends in site-specific benzo[a]pyrene diol epoxide-modified oligonucleotide duplexes.
Chemical research in toxicology 1996;9(1):255-61.
1996: Karam El-Bayoumy; Bogdan Prokopczyk; L A Peterson; D Desai; Shantu Amin; B S Reddy; D Hoffmann; E Wynder
Effects of dietary fat content on the metabolism of NNK and on DNA methylation induced by NNK.
Nutrition and cancer 1996;26(1):1-10.
1996: Shantu Amin; D Desai; Stephen S Hecht; D Hoffmann
Synthesis of tobacco-specific N-nitrosamines and their metabolites and results of related bioassays.
Critical reviews in toxicology 1996;26(2):139-47.
1995: D Desai; M Nunes; L Chang; J M Lin; D Jiao; Shantu Amin
Ipomeanol analogs as chemopreventive agents: effect on the in vitro metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
Cancer letters 1995;97(2):155-62.
1995: Shantu Amin; D Desai; W Dai; R G Harvey; Stephen S Hecht
Tumorigenicity in newborn mice of fjord region and other sterically hindered diol epoxides of benzo[g]chrysene, dibenzo[a,l]pyrene (dibenzo[def,p]chrysene), 4H-cyclopenta[def]chrysene and fluoranthene.
Carcinogenesis 1995;16(11):2813-7.
1995: Shantu Amin; J Krzeminski; Abraham Rivenson; C Kurtzke; Stephen S Hecht; Karam El-Bayoumy
Mammary carcinogenicity in female CD rats of fjord region diol epoxides of benzo[c]phenanthrene, benzo[g]chrysene and dibenzo[a,l]pyrene.
Carcinogenesis 1995;16(8):1971-4.
1995: Stephen S Hecht; Shantu Amin; J M Lin; Abraham Rivenson; C Kurtzke; Karam El-Bayoumy
Mammary carcinogenicity in female CD rats of a diol epoxide metabolite of fluoranthene, a commonly occurring environmental pollutant.
Carcinogenesis 1995;16(6):1433-5.
1995: M Cosman; R Xu; Brian E Hingerty; Shantu Amin; R G Harvey; Nicholas E Geacintov; Suse Broyde; Dinshaw J Patel
Solution conformation of the (-)-trans-anti-5-methylchrysene-dG adduct opposite dC in a DNA duplex: DNA bending associated with wedging of the methyl group of 5-methylchrysene to the 3'-side of the modification site.
Biochemistry 1995;34(18):6247-60.
1995: A Laryea; M Cosman; J M Lin; T Liu; R Agarwal; S Smirnov; Shantu Amin; R G Harvey; A Dipple; Nicholas E Geacintov
Direct synthesis and characterization of site-specific adenosyl adducts derived from the binding of a 3,4-dihydroxy-1,2-epoxybenzo[c]phenanthrene stereoisomer to an 11-mer oligodeoxyribonucleotide.
Chemical research in toxicology 1995;8(3):444-54.
1995: B Li; B Mao; T M Liu; J Xu; A Dourandin; Shantu Amin; Nicholas E Geacintov
Laser pulse-induced photochemical strand cleavage of site-specifically and covalently modified (+)-anti-benzo[a]pyrene diol epoxide-oligonucleotide adducts.
Chemical research in toxicology 1995;8(3):396-402.
1995: M Cosman; A Laryea; R Fiala; Brian E Hingerty; Shantu Amin; Nicholas E Geacintov; Suse Broyde; Dinshaw J Patel
Solution conformation of the (-)-trans-anti-benzo[c]phenanthrene-dA ([BPh]dA) adduct opposite dT in a DNA duplex: intercalation of the covalently attached benzo[c]phenanthrenyl ring to the 3'-side of the adduct site and comparison with the (+)-trans-anti-[BPh]dA opposite dT stereoisomer.
Biochemistry 1995;34(4):1295-307.
1994: L R Dolan; Susan Rutberg; Shantu Amin; M Emura; U Mohr; Andrew Kraft; K Yokoyama; Ze'ev Ronai
Regulation of c-jun by lung carcinogens in Clara cells of hamsters.
Carcinogenesis 1994;15(12):2789-93.
1994: D Desai; J Krzeminski; Shantu Amin
Convenient synthesis of 3-methoxybenz[a]anthracene-7,12-dione.
Chemical research in toxicology 1994;7(6):722-3.
1994: Ze'ev Ronai; S Gradia; Karam El-Bayoumy; Shantu Amin; Stephen S Hecht
Contrasting incidence of ras mutations in rat mammary and mouse skin tumors induced by anti-benzo[c]phenanthrene-3,4-diol-1,2-epoxide.
Carcinogenesis 1994;15(10):2113-6.
1994: M Cosman; R Fiala; Brian E Hingerty; Shantu Amin; Nicholas E Geacintov; Suse Broyde; Dinshaw J Patel
Solution conformation of the (+)-cis-anti-[BP]dG adduct opposite a deletion site in a DNA duplex: intercalation of the covalently attached benzo[a]pyrene into the helix with base displacement of the modified deoxyguanosine into the minor groove.
Biochemistry 1994;33(38):11518-27.
1994: M Cosman; R Fiala; Brian E Hingerty; Shantu Amin; Nicholas E Geacintov; Suse Broyde; Dinshaw J Patel
Solution conformation of the (+)-trans-anti-[BP]dG adduct opposite a deletion site in a DNA duplex: intercalation of the covalently attached benzo[a]pyrene into the helix with base displacement of the modified deoxyguanosine into the major groove.
Biochemistry 1994;33(38):11507-17.
1994: J Krzeminski; J M Lin; Shantu Amin; Stephen S Hecht
Synthesis of Fjord region diol epoxides as potential ultimate carcinogens of dibenzo[a,l]pyrene.
Chemical research in toxicology 1994;7(2):125-9.
1994: Stephen S Hecht; Karam El-Bayoumy; Abraham Rivenson; Shantu Amin
Potent mammary carcinogenicity in female CD rats of a fjord region diol-epoxide of benzo[c]phenanthrene compared to a bay region diol-epoxide of benzo[a]pyrene.
Cancer research 1994;54(1):21-4.
1993: M Cosman; R Fiala; Brian E Hingerty; A Laryea; H Lee; R G Harvey; Shantu Amin; Nicholas E Geacintov; Suse Broyde; Dinshaw J Patel
Solution conformation of the (+)-trans-anti-[BPh]dA adduct opposite dT in a DNA duplex: intercalation of the covalently attached benzo[c]phenanthrene to the 5'-side of the adduct site without disruption of the modified base pair.
Biochemistry 1993;32(46):12488-97.
1993: B Mao; B Li; Shantu Amin; M Cosman; Nicholas E Geacintov
Opposite stereoselective resistance to digestion by phosphodiesterases I and II of benzo[a]pyrene diol epoxide-modified oligonucleotide adducts.
Biochemistry 1993;32(44):11785-93.
1993: J M Lin; Shantu Amin; N Trushin; Stephen S Hecht
Effects of isothiocyanates on tumorigenesis by benzo[a]pyrene in murine tumor models.
Cancer letters 1993;74(3):151-9.
1993: D Desai; S S Kagan; Shantu Amin; Steven G Carmella; Stephen S Hecht
Identification of 4-(methylnitrosamino)-1-[3-(6-hydroxypyridyl)]-1-butanone as a urinary metabolite of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in rodents.
Chemical research in toxicology 1993;6(6):794-9.
1993: Shantu Amin; D Desai; Stephen S Hecht
Tumor-initiating activity on mouse skin of bay region diol-epoxides of 5,6-dimethylchrysene and benzo[c]phenanthrene.
Carcinogenesis 1993;14(10):2033-7.
1993: L Balasta; R Xu; Nicholas E Geacintov; C E Swenberg; Shantu Amin; Stephen S Hecht
Unwinding and hydrodynamic flow linear dichroism characteristics of supercoiled DNA covalently modified with two isomeric methylchrysene diol epoxides of different biological activities.
Chemical research in toxicology 1993;6(5):616-24.
1993: D Hoffmann; M V Djordjevic; Abraham Rivenson; Edith Zang; D Desai; Shantu Amin
A study of tobacco carcinogenesis. LI. Relative potencies of tobacco-specific N-nitrosamines as inducers of lung tumours in A/J mice.
Cancer letters 1993;71(1-3):25-30.
1993: Karam El-Bayoumy; P Upadhyaya; Dhimant Desai; Shantu Amin; Stephen S Hecht
Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone tumorigenicity in mouse lung by the synthetic organoselenium compound, 1,4-phenylenebis(methylene)selenocyanate.
Carcinogenesis 1993;14(6):1111-3.
1992: Karam El-Bayoumy; D Desai; P Upadhyaya; Shantu Amin; Stephen S Hecht
Comparative tumorigenicity of nitrochrysene isomers in newborn mice.
Carcinogenesis 1992;13(12):2271-5.
1992: B Misra; J M Lin; Shantu Amin; Stephen S Hecht
Distinct conformers of alkylchrysene diol epoxide-deoxyguanosine adducts detected by proton NMR.
Chemical research in toxicology 1992;5(6):756-9.
1992: J M Lin; Dhimant Desai; Mark A Morse; Shantu Amin; Stephen S Hecht
Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone pulmonary metabolism and tumorigenicity in mice by analogues of the investigational chemotherapeutic drug 4-ipomeanol.
Chemical research in toxicology 1992;5(5):674-9.
1992: S E Murphy; Shantu Amin; K Coletta; D Hoffmann
Rat liver metabolism of benzo[b]naphtho[2,1-d]thiophene.
Chemical research in toxicology 1992;5(4):491-5.
1992: B Misra; Shantu Amin; Stephen S Hecht
Dimethylchrysene diol epoxides: mutagenicity in Salmonella typhimurium, tumorigenicity in newborn mice, and reactivity with deoxyadenosine in DNA.
Chemical research in toxicology 1992;5(2):248-54.
1992: B Misra; Shantu Amin; Stephen S Hecht
Metabolism and DNA binding of 5,6-dimethylchrysene in mouse skin.
Chemical research in toxicology 1992;5(2):242-7.
1992: Shantu Amin; D Desai; Stephen S Hecht
Comparative tumorigenicity of dimethylchrysenes in mouse skin.
Chemical research in toxicology 1992;5(2):237-41.
1991: Dhimant Desai; Shantu Amin
Synthesis of a hapten to be used in development of immunoassays for trans-3'-hydroxycotinine, a major metabolite of cotinine.
Chemical research in toxicology 1991;4(5):524-7.
1991: Shantu Amin; B Misra; J Braley; Stephen S Hecht
Comparative tumorigenicity in newborn mice of chrysene- and 5-alkylchrysene-1,2-diol-3,4-epoxides.
Cancer letters 1991;58(1-2):115-8.
1990: Nicholas E Geacintov; M S Lee; V Ibanez; Shantu Amin; Stephen S Hecht
Differences in conformations of covalent adducts derived from the binding of 5- and 6-methylchrysene diol epoxide stereoisomers to DNA.
Carcinogenesis 1990;11(6):985-9.
1990: Shantu Amin; Stephen S Hecht; P Di Raddo; R G Harvey
Comparative tumor initiating activities of cyclopentano and methyl derivatives of 5-methylchrysene and chrysene.
Cancer letters 1990;51(1):17-20.
1990: B Misra; Shantu Amin
Synthesis and mutagenicity of trans-dihydrodiol metabolites of benzo[b]naphtho[2,1-d]thiophene.
Chemical research in toxicology 1990;3(2):93-7.
1990: D Desai; Shantu Amin
A convenient synthesis of trans-3'-hydroxycotinine, a major nicotine metabolite found in the urine of tobacco users.
Chemical research in toxicology 1990;3(1):47-8.
1989: Stephen S Hecht; Mark A Morse; Shantu Amin; G D Stoner; K G Jordan; C I Choi; Fung-Lung Chung
Rapid single-dose model for lung tumor induction in A/J mice by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and the effect of diet.
Carcinogenesis 1989;10(10):1901-4.
1989: Shantu Amin; B Misra; D Desai; K Huie; Stephen S Hecht
Chromatographic conditions for separation of 32P-labeled phosphates of major polynuclear aromatic hydrocarbon--deoxyribonucleoside adducts.
Carcinogenesis 1989;10(10):1971-4.
1989: Abraham Rivenson; M V Djordjevic; Shantu Amin; R Hoffmann
A study of tobacco carcinogenesis XLIV. Bioassay in A/J mice of some N-nitrosamines.
Cancer letters 1989;47(1-2):111-4.
1989: Karam El-Bayoumy; G H Shiue; Shantu Amin; Stephen S Hecht
The effects of bay-region methyl substitution on 6-nitrochrysene mutagenicity in Salmonella typhimurium and tumorigenicity in newborn mice.
Carcinogenesis 1989;10(9):1685-9.
1988: Shantu Amin; K Huie; G Balanikas; Stephen S Hecht
Synthesis and mutagenicity of 5-alkyl-substituted chrysene-1,2-diol-3,4-epoxides.
Carcinogenesis 1988;9(12):2305-8.
1988: Abraham Rivenson; D Hoffmann; Bogdan Prokopczyk; Shantu Amin; Stephen S Hecht
Induction of lung and exocrine pancreas tumors in F344 rats by tobacco-specific and Areca-derived N-nitrosamines.
Cancer research 1988;48(23):6912-7.
1988: Shantu Amin; G Balanikas; K Huie; Stephen S Hecht
Synthesis and tumor-initiating activities of dimethylchrysenes.
Chemical research in toxicology 1988;1(6):349-55.
1988: Assieh A Melikian; Shantu Amin; K Huie; Stephen S Hecht; R G Harvey
Reactivity with DNA bases and mutagenicity toward Salmonella typhimurium of methylchrysene diol epoxide enantiomers.
Cancer research 1988;48(7):1781-7.
1987: J E Geddie; Shantu Amin; K Huie; Stephen S Hecht
Formation and tumorigenicity of benzo[b]fluoranthene metabolites in mouse epidermis.
Carcinogenesis 1987;8(11):1579-84.
1987: Stephen S Hecht; Shantu Amin; K Huie; Assieh A Melikian; R G Harvey
Enhancing effect of a bay region methyl group on tumorigenicity in newborn mice and mouse skin of enantiomeric bay region diol epoxides formed stereoselectively from methylchrysenes in mouse epidermis.
Cancer research 1987;47(20):5310-5.
1987: Shantu Amin; K Huie; G Balanikas; Stephen S Hecht; J Pataki; R G Harvey
High stereoselectivity in mouse skin metabolic activation of methylchrysenes to tumorigenic dihydrodiols.
Cancer research 1987;47(14):3613-7.
1985: Shantu Amin; K Huie; Assieh A Melikian; J M Leszczynska; Stephen S Hecht
Comparative metabolic activation in mouse skin of the weak carcinogen 6-methylchrysene and the strong carcinogen 5-methylchrysene.
Cancer research 1985;45(12 Pt 1):6406-42.
1985: Assieh A Melikian; J M Leszczynska; Shantu Amin; Stephen S Hecht; D Hoffmann; J Pataki; R G Harvey
Rates of hydrolysis and extents of DNA binding of 5-methylchrysene dihydrodiol epoxides.
Cancer research 1985;45(5):1990-6.
1985: Shantu Amin; N Hussain; G Balanikas; K Huie; Stephen S Hecht
Mutagenicity and tumor initiating activity of methylated benzo[k] fluoranthenes.
Cancer letters 1985;26(3):343-7.
1985: Stephen S Hecht; L Radok; Shantu Amin; K Huie; Assieh A Melikian; D Hoffmann; J Pataki; R G Harvey
Tumorigenicity of 5-methylchrysene dihydrodiols and dihydrodiol epoxides in newborn mice and on mouse skin.
Cancer research 1985;45(4):1449-52.
1984: Assieh A Melikian; Shantu Amin; Stephen S Hecht; D Hoffmann; J Pataki; R G Harvey
Identification of the major adducts formed by reaction of 5-methylchrysene anti-dihydrodiol-epoxides with DNA in vitro.
Cancer research 1984;44(6):2524-9.