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Agnieszka Dobrzyn

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Michael J MacDonald; James M Ntambi; Agnieszka Dobrzyn; Noaman M Hasan; Xueqing Liu; Scott W Stoker; Harini Sampath
Knockdown of pyruvate carboxylase or fatty acid synthase lowers numerous lipids and glucose-stimulated insulin release in insulinoma cells.
Anna Dziewulska; Magdalena Jazurek; James M Ntambi; Aleksandra Pyrkowska; Pawel Dobrzyn; Agnieszka Dobrzyn
Monounsaturated fatty acids are required for membrane translocation of protein kinase C-theta induced by lipid overload in skeletal muscle.
Pawel Brzek; Agnieszka Dobrzyn; Aneta Ksiazek; Marek Konarzewski
Effect of dietary restriction on metabolic, anatomic and molecular traits in mice depends on the initial level of basal metabolic rate.

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All Publications

2013: Michael J MacDonald; James M Ntambi; Agnieszka Dobrzyn; Noaman M Hasan; Xueqing Liu; Scott W Stoker; Harini Sampath
Knockdown of pyruvate carboxylase or fatty acid synthase lowers numerous lipids and glucose-stimulated insulin release in insulinoma cells.
Archives of biochemistry and biophysics 2013;532(1):23-31.
2012: Anna Dziewulska; Magdalena Jazurek; James M Ntambi; Aleksandra Pyrkowska; Pawel Dobrzyn; Agnieszka Dobrzyn
Monounsaturated fatty acids are required for membrane translocation of protein kinase C-theta induced by lipid overload in skeletal muscle.
Molecular membrane biology 2012;29(7):309-20.
2012: Pawel Brzek; Agnieszka Dobrzyn; Aneta Ksiazek; Marek Konarzewski
Effect of dietary restriction on metabolic, anatomic and molecular traits in mice depends on the initial level of basal metabolic rate.
The Journal of experimental biology 2012;215(Pt 18):3191-9.
2012: Malgorzata E Sztolsztener; Anna Tylki-Szymanska; Agnieszka Dobrzyn; Slawomir Pikula; Joanna Bandorowicz-Pikula
Impaired dynamics of the late endosome/lysosome compartment in human Niemann-Pick type C skin fibroblasts carrying mutation in NPC1 gene.
Molecular bioSystems 2012;8(4):1197-205.
2012: Pawel Dobrzyn; Magdalena Jazurek; Aleksandra Pyrkowska; Agnieszka Dobrzyn
Increased availability of endogenous and dietary oleic acid contributes to the upregulation of cardiac fatty acid oxidation.
Mitochondrion 2012;12(1):132-7.
2010: Pawel Dobrzyn; Agnieszka Dobrzyn; Makoto Miyazaki; James M Ntambi
Loss of stearoyl-CoA desaturase 1 rescues cardiac function in obese leptin-deficient mice.
Journal of lipid research 2010;51(8):2202-10.
2010: Pawel Dobrzyn; Agnieszka Dobrzyn
Novel substituted heteroaromatic compounds as inhibitors of stearoyl-CoA desaturase.
Expert opinion on therapeutic patents 2010;20(6):849-53.
2010: Pawel Dobrzyn; Magdalena Jazurek; Agnieszka Dobrzyn
Stearoyl-CoA desaturase and insulin signaling--what is the molecular switch?
Biochimica et biophysica acta 2010;1797(6-7):1189-94.
2009: Makoto Miyazaki; Harini Sampath; Xueqing Liu; Matthew Flowers; Kiki Chu; Agnieszka Dobrzyn; James M Ntambi
Stearoyl-CoA desaturase-1 deficiency attenuates obesity and insulin resistance in leptin-resistant obese mice.
Biochemical and biophysical research communications 2009;380(4):818-22.
2008: Robert Zarnowski; Agnieszka Dobrzyn; James M Ntambi; Jon P Woods
Ferrous, but not ferric, iron maintains homeostasis in Histoplasma capsulatum triacylglycerides.
Current microbiology 2008;57(2):153-7.
2008: Michael J MacDonald; Agnieszka Dobrzyn; James M Ntambi; Scott W Stoker
The role of rapid lipogenesis in insulin secretion: Insulin secretagogues acutely alter lipid composition of INS-1 832/13 cells.
Archives of biochemistry and biophysics 2008;470(2):153-62.
2008: Pawel Dobrzyn; Harini Sampath; Agnieszka Dobrzyn; Makoto Miyazaki; James M Ntambi
Loss of stearoyl-CoA desaturase 1 inhibits fatty acid oxidation and increases glucose utilization in the heart.
American journal of physiology. Endocrinology and metabolism 2008;294(2):E357-64.
2008: Robert Zarnowski; Agnieszka Dobrzyn; James M Ntambi; Jon P Woods
Neutral storage lipids of Histoplasma capsulatum: effect of culture age.
Current microbiology 2008;56(2):110-4.
2008: Wojciech Modrzejewski; Malgorzata Knapp; Agnieszka Dobrzyn; Wlodzimierz J Musial; Jan Górski
[Ceramides and adhesive molecules in stable ischaemic heart disease].
Przegla̧d lekarski 2008;65(3):131-4.
2007: Robert Zarnowski; Makoto Miyazaki; Agnieszka Dobrzyn; James M Ntambi; Jon P Woods
Typing of Histoplasma capsulatum strains by fatty acid profile analysis.
Journal of medical microbiology 2007;56(Pt 6):788-97.
2007: Harini Sampath; Makoto Miyazaki; Agnieszka Dobrzyn; James M Ntambi
Stearoyl-CoA desaturase-1 mediates the pro-lipogenic effects of dietary saturated fat.
The Journal of biological chemistry 2007;282(4):2483-93.
2005: Makoto Miyazaki; Agnieszka Dobrzyn; Peter M Elias; James M Ntambi
Stearoyl-CoA desaturase-2 gene expression is required for lipid synthesis during early skin and liver development.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(35):12501-6.
2005: Agnieszka Dobrzyn; Pawel Dobrzyn; Makoto Miyazaki; James M Ntambi
Polyunsaturated fatty acids do not activate AMP-activated protein kinase in mouse tissues.
Biochemical and biophysical research communications 2005;332(3):892-6.
2005: Agnieszka Dobrzyn; James M Ntambi
The role of stearoyl-CoA desaturase in the control of metabolism.
Prostaglandins, leukotrienes, and essential fatty acids 2005;73(1):35-41.
2005: Agnieszka Dobrzyn; Pawel Dobrzyn; Makoto Miyazaki; Harini Sampath; Kiki Chu; James M Ntambi
Stearoyl-CoA desaturase 1 deficiency increases CTP:choline cytidylyltransferase translocation into the membrane and enhances phosphatidylcholine synthesis in liver.
The Journal of biological chemistry 2005;280(24):23356-62.
2005: Agnieszka Dobrzyn; James M Ntambi
Stearoyl-CoA desaturase as a new drug target for obesity treatment.
Obesity reviews : an official journal of the International Association for the Study of Obesity 2005;6(2):169-74.
2005: Agnieszka Dobrzyn; Pawel Dobrzyn; Seong-Ho Lee; Makoto Miyazaki; Paul Cohen; Esra Asilmaz; D Grahame Hardie; Jeffrey M Friedman; James M Ntambi
Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2005;288(3):E599-607.
2005: Rahman Shaikh; Agnieszka Dobrzyn; Seong-Ho Lee; Pawel Dobrzyn; Makoto Miyazaki; James M Ntambi
Stearoyl-CoA desaturase 1 deficiency increases insulin signaling and glycogen accumulation in brown adipose tissue.
American journal of physiology. Endocrinology and metabolism 2005;288(2):E381-7.
2004: James M Ntambi; Makoto Miyazaki; Agnieszka Dobrzyn
Regulation of stearoyl-CoA desaturase expression.
Lipids 2004;39(11):1061-5.
2004: Seong-Ho Lee; Agnieszka Dobrzyn; Pawel Dobrzyn; Rahman Shaikh; Makoto Miyazaki; James M Ntambi
Lack of stearoyl-CoA desaturase 1 upregulates basal thermogenesis but causes hypothermia in a cold environment.
Journal of lipid research 2004;45(9):1674-82.
2004: Makoto Miyazaki; Agnieszka Dobrzyn; Harini Sampath; Seong-Ho Lee; Weng Chi Man; Kiki Chu; Jeffrey M Peters; Frank J Gonzalez; James M Ntambi
Reduced adiposity and liver steatosis by stearoyl-CoA desaturase deficiency are independent of peroxisome proliferator-activated receptor-alpha.
The Journal of biological chemistry 2004;279(33):35017-24.
2004: Makoto Miyazaki; Agnieszka Dobrzyn; Weng Chi Man; Kiki Chu; Harini Sampath; Hyoun-Ju Kim; James M Ntambi
Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1c-dependent and -independent mechanisms.
The Journal of biological chemistry 2004;279(24):25164-71.
2004: Richard A Wilson; Perng-Kuang Chang; Agnieszka Dobrzyn; James M Ntambi; Robert Zarnowski; Nancy P Keller
Two Delta9-stearic acid desaturases are required for Aspergillus nidulans growth and development.
Fungal genetics and biology : FG & B 2004;41(5):501-9.
2004: Pawel Dobrzyn; Agnieszka Dobrzyn; Makoto Miyazaki; Paul Cohen; Esra Asilmaz; D Grahame Hardie; Jeffrey M Friedman; James M Ntambi
Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(17):6409-14.
2004: Agnieszka Dobrzyn; James M Ntambi
The role of stearoyl-CoA desaturase in body weight regulation.
Trends in cardiovascular medicine 2004;14(2):77-81.
2004: Jørn Wulff Helge; Agnieszka Dobrzyn; Bengt Saltin; Jan Gorski
Exercise and training effects on ceramide metabolism in human skeletal muscle.
Experimental physiology 2004;89(1):119-27.
2003: Jonathan T Goldstein; Agnieszka Dobrzyn; Margaret Clagett-Dame; J Wesley Pike; Hector F Deluca
Isolation and characterization of unsaturated fatty acids as natural ligands for the retinoid-X receptor.
Archives of biochemistry and biophysics 2003;420(1):185-93.
2003: Rahman Shaikh; Agnieszka Dobrzyn; Pawel Dobrzyn; Seong-Ho Lee; Makoto Miyazaki; James M Ntambi
Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B in muscle.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):11110-5.
2002: Jan Górski; Agnieszka Dobrzyn; Malgorzata Zendzian-Piotrowska
The sphingomyelin-signaling pathway in skeletal muscles and its role in regulation of glucose uptake.
Annals of the New York Academy of Sciences 2002;967():236-48.