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Christopher Dobson

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Physiology

Protein Folding

Concepts & Ideas

Disorders

Protein Denaturation

Chemicals & Drugs

Phenomena

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Publications

TOP 3
Vuchelen Anneleen; O'Day Elizabeth; De Genst Erwin; Pardon Els; Wyns Lode; Dumoulin Mireille; Dobson Christopher M; Christodoulou John; Hsu Shang-Te Danny
(1)H, (13)C and (15)N assignments of a camelid nanobody directed against human alpha-synuclein.
Bui Jennifer M; Gsponer Jörg; Vendruscolo Michele; Dobson Christopher M
Analysis of sub-tauc and supra-tauc motions in protein Gbeta1 using molecular dynamics simulations.
Lendel Christofer; Bertoncini Carlos W; Cremades Nunilo; Waudby Christopher A; Vendruscolo Michele; Dobson Christopher M; Schenk Dale; Christodoulou John; Toth Gergely
On the mechanism of nonspecific inhibitors of protein aggregation: dissecting the interactions of alpha-synuclein with Congo red and Lacmoid.

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All Publications

2009: Vuchelen Anneleen; O'Day Elizabeth; De Genst Erwin; Pardon Els; Wyns Lode; Dumoulin Mireille; Dobson Christopher M; Christodoulou John; Hsu Shang-Te Danny
(1)H, (13)C and (15)N assignments of a camelid nanobody directed against human alpha-synuclein.
Biomolecular NMR assignments 2009;3(2):231-3.
2009: Bui Jennifer M; Gsponer Jörg; Vendruscolo Michele; Dobson Christopher M
Analysis of sub-tauc and supra-tauc motions in protein Gbeta1 using molecular dynamics simulations.
Biophysical journal 2009;97(9):2513-20.
2009: Lendel Christofer; Bertoncini Carlos W; Cremades Nunilo; Waudby Christopher A; Vendruscolo Michele; Dobson Christopher M; Schenk Dale; Christodoulou John; Toth Gergely
On the mechanism of nonspecific inhibitors of protein aggregation: dissecting the interactions of alpha-synuclein with Congo red and Lacmoid.
Biochemistry 2009;48(35):8322-34.
2009: Luheshi Leila M; Dobson Christopher M
Bridging the gap: from protein misfolding to protein misfolding diseases.
FEBS letters 2009;583(16):2581-6.
2009: White Duncan A; Buell Alexander K; Dobson Christopher M; Welland Mark E; Knowles Tuomas P J
Biosensor-based label-free assays of amyloid growth.
FEBS letters 2009;583(16):2587-92.
2009: Bodner Christina R; Dobson Christopher M; Bax Ad
Multiple tight phospholipid-binding modes of alpha-synuclein revealed by solution NMR spectroscopy.
Journal of molecular biology 2009;390(4):775-90.
2009: Hsu Shang-Te Danny; Behrens Caroline; Cabrita Lisa D; Dobson Christopher M
1H, 15N and 13C assignments of yellow fluorescent protein (YFP) Venus.
Biomolecular NMR assignments 2009;3(1):67-72.
2009: Hsu Shang-Te Danny; Cabrita Lisa D; Christodoulou John; Dobson Christopher M
1H, 15N and 13C assignments of domain 5 of Dictyostelium discoideum gelation factor (ABP-120) in its native and 8M urea-denatured states.
Biomolecular NMR assignments 2009;3(1):29-31.
2009: Hsu Shang-Te Danny; Dobson Christopher M
1H, 15N and 13C assignments of the dimeric ribosome binding domain of trigger factor from Escherichia coli.
Biomolecular NMR assignments 2009;3(1):17-20.
2009: Hsu Shang-Te Danny; Cabrita Lisa D; Fucini Paola; Christodoulou John; Dobson Christopher M
Probing side-chain dynamics of a ribosome-bound nascent chain using methyl NMR spectroscopy.
Journal of the American Chemical Society 2009;131(24):8366-7.
2009: Hsu Shang-Te Danny; Bertoncini Carlos W; Dobson Christopher M
Use of protonless NMR spectroscopy to alleviate the loss of information resulting from exchange-broadening.
Journal of the American Chemical Society 2009;131(21):7222-3.
2009: Robustelli Paul; Cavalli Andrea; Dobson Christopher M; Vendruscolo Michele; Salvatella Xavier
Folding of small proteins by Monte Carlo simulations with chemical shift restraints without the use of molecular fragment replacement or structural homology.
The journal of physical chemistry. B 2009;113(22):7890-6.
2009: Carulla Natàlia; Zhou Min; Arimon Muriel; Gairí Margarida; Giralt Ernest; Robinson Carol V; Dobson Christopher M
Experimental characterization of disordered and ordered aggregates populated during the process of amyloid fibril formation.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(19):7828-33.
2009: Buell Alexander K; Tartaglia Gian Gaetano; Birkett Neil R; Waudby Christopher A; Vendruscolo Michele; Salvatella Xavier; Welland Mark E; Dobson Christopher M; Knowles Tuomas P J
Position-dependent electrostatic protection against protein aggregation.
Chembiochem : a European journal of chemical biology 2009;10(8):1309-12.
2009: Tartaglia Gian Gaetano; Pechmann Sebastian; Dobson Christopher M; Vendruscolo Michele
A relationship between mRNA expression levels and protein solubility in E. coli.
Journal of molecular biology 2009;388(2):381-9.
2009: Hsu Shang-Te Danny; Cabrita Lisa D; Fucini Paola; Dobson Christopher M; Christodoulou John
Structure, dynamics and folding of an immunoglobulin domain of the gelation factor (ABP-120) from Dictyostelium discoideum.
Journal of molecular biology 2009;388(4):865-79.
2009: Calamai Martino; Tartaglia Gian Gaetano; Vendruscolo Michele; Chiti Fabrizio; Dobson Christopher M
Mutational analysis of the aggregation-prone and disaggregation-prone regions of acylphosphatase.
Journal of molecular biology 2009;387(4):965-74.
2009: Frare Erica; Mossuto Maria F; de Laureto Patrizia Polverino; Tolin Serena; Menzer Linda; Dumoulin Mireille; Dobson Christopher M; Fontana Angelo
Characterization of oligomeric species on the aggregation pathway of human lysozyme.
Journal of molecular biology 2009;387(1):17-27.
2009: Yerbury Justin J; Kumita Janet R; Meehan Sarah; Dobson Christopher M; Wilson Mark R
alpha2-Macroglobulin and haptoglobin suppress amyloid formation by interacting with prefibrillar protein species.
The Journal of biological chemistry 2009;284(7):4246-54.
2009: Bayro Marvin J; Maly Thorsten; Birkett Neil R; Dobson Christopher M; Griffin Robert G
Long-range correlations between aliphatic 13C nuclei in protein MAS NMR spectroscopy.
Angewandte Chemie (International ed. in English) 2009;48(31):5708-10.
2009: Yanamandra Kiran; Alexeyev Oleg; Zamotin Vladimir; Srivastava Vaibhav; Shchukarev Andrei; Brorsson Ann-Christin; Tartaglia Gian Gaetano; Vogl Thomas; Kayed Rakez; Wingsle Gunnar; Olsson Jan; Dobson Christopher M; Bergh Anders; Elgh Fredrik; Morozova-Roche Ludmilla A
Amyloid formation by the pro-inflammatory S100A8/A9 proteins in the ageing prostate.
PloS one 2009;4(5):e5562.
2008: Chan Pak-Ho; Pardon Els; Menzer Linda; De Genst Erwin; Kumita Janet R; Christodoulou John; Saerens Dirk; Brans Alain; Bouillenne Fabrice; Archer David B; Robinson Carol V; Muyldermans Serge; Matagne André; Redfield Christina; Wyns Lode; Dobson Christopher M; Dumoulin Mireille
Engineering a camelid antibody fragment that binds to the active site of human lysozyme and inhibits its conversion into amyloid fibrils.
Biochemistry 2008;47(42):11041-54.
2008: Calloni Giulia; Lendel Christofer; Campioni Silvia; Giannini Silva; Gliozzi Alessandra; Relini Annalisa; Vendruscolo Michele; Dobson Christopher M; Salvatella Xavier; Chiti Fabrizio
Structure and dynamics of a partially folded protein are decoupled from its mechanism of aggregation.
Journal of the American Chemical Society 2008;130(39):13040-50.
2008: Roodveldt Cintia; Christodoulou John; Dobson Christopher M
Immunological features of alpha-synuclein in Parkinson's disease.
Journal of cellular and molecular medicine 2008;12(5B):1820-9.
2008: Orte Angel; Birkett Neil R; Clarke Richard W; Devlin Glyn L; Dobson Christopher M; Klenerman David
Direct characterization of amyloidogenic oligomers by single-molecule fluorescence.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(38):14424-9.
2008: Tartaglia Gian Gaetano; Pawar Amol P; Campioni Silvia; Dobson Christopher M; Chiti Fabrizio; Vendruscolo Michele
Prediction of aggregation-prone regions in structured proteins.
Journal of molecular biology 2008;380(2):425-36.
2008: Gsponer Jörg; Christodoulou John; Cavalli Andrea; Bui Jennifer M; Richter Barbara; Dobson Christopher M; Vendruscolo Michele
A coupled equilibrium shift mechanism in calmodulin-mediated signal transduction.
Structure (London, England : 1993) 2008;16(5):736-46.
2008: Rivers Robert C; Kumita Janet R; Tartaglia Gian Gaetano; Dedmon Matthew M; Pawar Amol; Vendruscolo Michele; Dobson Christopher M; Christodoulou John
Molecular determinants of the aggregation behavior of alpha- and beta-synuclein.
Protein science : a publication of the Protein Society 2008;17(5):887-98.
2008: Gras Sally L; Tickler Anna K; Squires Adam M; Devlin Glyn L; Horton Michael A; Dobson Christopher M; MacPhee Cait E
Functionalised amyloid fibrils for roles in cell adhesion.
Biomaterials 2008;29(11):1553-62.
2008: van Nuland Nico A J; Dobson Christopher M; Regan Lynne
Characterization of folding the four-helix bundle protein Rop by real-time NMR.
Protein engineering, design & selection : PEDS 2008;21(3):165-70.
2008: Várnai Péter; Dobson Christopher M; Vendruscolo Michele
Determination of the transition state ensemble for the folding of ubiquitin from a combination of Phi and Psi analyses.
Journal of molecular biology 2008;377(2):575-88.
2008: Luheshi Leila M; Crowther Damian C; Dobson Christopher M
Protein misfolding and disease: from the test tube to the organism.
Current opinion in chemical biology 2008;12(1):25-31.
2008: Cheon Mookyung; Favrin Giorgio; Chang Iksoo; Dobson Christopher M; Vendruscolo Michele
Calculation of the free energy barriers in the oligomerisation of Abeta peptide fragments.
Frontiers in bioscience : a journal and virtual library 2008;13():5614-22.
2008: Baldwin Andrew J; Anthony-Cahill Spencer J; Knowles Tuomas P J; Lippens Guy; Christodoulou John; Barker Paul D; Dobson Christopher M
Measurement of amyloid fibril length distributions by inclusion of rotational motion in solution NMR diffusion measurements.
Angewandte Chemie (International ed. in English) 2008;47(18):3385-7.
2007: Knowles Tuomas P; Fitzpatrick Anthony W; Meehan Sarah; Mott Helen R; Vendruscolo Michele; Dobson Christopher M; Welland Mark E
Role of intermolecular forces in defining material properties of protein nanofibrils.
Science (New York, N.Y.) 2007;318(5858):1900-3.
2007: Luheshi Leila M; Tartaglia Gian Gaetano; Brorsson Ann-Christin; Pawar Amol P; Watson Ian E; Chiti Fabrizio; Vendruscolo Michele; Lomas David A; Dobson Christopher M; Crowther Damian C
Systematic in vivo analysis of the intrinsic determinants of amyloid Beta pathogenicity.
PLoS biology 2007;5(11):e290.
2007: Hsu Shang-Te Danny; Fucini Paola; Cabrita Lisa D; Launay Hélène; Dobson Christopher M; Christodoulou John
Structure and dynamics of a ribosome-bound nascent chain by NMR spectroscopy.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(42):16516-21.
2007: Cheon Mookyung; Chang Iksoo; Mohanty Sandipan; Luheshi Leila M; Dobson Christopher M; Vendruscolo Michele; Favrin Giorgio
Structural reorganisation and potential toxicity of oligomeric species formed during the assembly of amyloid fibrils.
PLoS computational biology 2007;3(9):1727-38.
2007: Baldwin Andrew J; Christodoulou John; Barker Paul D; Dobson Christopher M; Lippens Guy
Contribution of rotational diffusion to pulsed field gradient diffusion measurements.
The Journal of chemical physics 2007;127(11):114505.
2007: Meehan Sarah; Knowles Tuomas P J; Baldwin Andrew J; Smith Jeffrey F; Squires Adam M; Clements Phillip; Treweek Teresa M; Ecroyd Heath; Tartaglia Gian Gaetano; Vendruscolo Michele; Macphee Cait E; Dobson Christopher M; Carver John A
Characterisation of amyloid fibril formation by small heat-shock chaperone proteins human alphaA-, alphaB- and R120G alphaB-crystallins.
Journal of molecular biology 2007;372(2):470-84.
2007: Yerbury Justin J; Poon Stephen; Meehan Sarah; Thompson Brianna; Kumita Janet R; Dobson Christopher M; Wilson Mark R
The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(10):2312-22.
2007: Auer Stefan; Dobson Christopher M; Vendruscolo Michele
Characterization of the nucleation barriers for protein aggregation and amyloid formation.
HFSP journal 2007;1(2):137-46.
2007: Knowles Tuomas P J; Shu Wenmiao; Devlin Glyn L; Meehan Sarah; Auer Stefan; Dobson Christopher M; Welland Mark E
Kinetics and thermodynamics of amyloid formation from direct measurements of fluctuations in fibril mass.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(24):10016-21.
2007: Cavalli Andrea; Salvatella Xavier; Dobson Christopher M; Vendruscolo Michele
Protein structure determination from NMR chemical shifts.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(23):9615-20.
2007: Meinhardt Jessica; Tartaglia Gian Gaetano; Pawar Amol; Christopeit Tony; Hortschansky Peter; Schroeckh Volker; Dobson Christopher M; Vendruscolo Michele; Fändrich Marcus
Similarities in the thermodynamics and kinetics of aggregation of disease-related Abeta(1-40) peptides.
Protein science : a publication of the Protein Society 2007;16(6):1214-22.
2007: Tartaglia Gian Gaetano; Pechmann Sebastian; Dobson Christopher M; Vendruscolo Michele
Life on the edge: a link between gene expression levels and aggregation rates of human proteins.
Trends in biochemical sciences 2007;32(5):204-6.
2007: Kumita Janet R; Poon Stephen; Caddy Gemma L; Hagan Christine L; Dumoulin Mireille; Yerbury Justin J; Stewart Elise M; Robinson Carol V; Wilson Mark R; Dobson Christopher M
The extracellular chaperone clusterin potently inhibits human lysozyme amyloid formation by interacting with prefibrillar species.
Journal of molecular biology 2007;369(1):157-67.
2006: Di Gaetano Sonia; Guglielmi Fulvio; Arciello Angela; Mangione Palma; Monti Maria; Pagnozzi Daniela; Raimondi Sara; Giorgetti Sofia; Orrù Stefania; Canale Claudio; Pucci Piero; Dobson Christopher M; Bellotti Vittorio; Piccoli Renata
Recombinant amyloidogenic domain of ApoA-I: analysis of its fibrillogenic potential.
Biochemical and biophysical research communications 2006;351(1):223-8.
2006: Gsponer Joerg; Hopearuoho Harri; Cavalli Andrea; Dobson Christopher M; Vendruscolo Michele
Geometry, energetics, and dynamics of hydrogen bonds in proteins: structural information derived from NMR scalar couplings.
Journal of the American Chemical Society 2006;128(47):15127-35.
2006: Calamai Martino; Kumita Janet R; Mifsud John; Parrini Claudia; Ramazzotti Matteo; Ramponi Giampietro; Taddei Niccoló; Chiti Fabrizio; Dobson Christopher M
Nature and significance of the interactions between amyloid fibrils and biological polyelectrolytes.
Biochemistry 2006;45(42):12806-15.
2006: Smith Jeffrey F; Knowles Tuomas P J; Dobson Christopher M; Macphee Cait E; Welland Mark E
Characterization of the nanoscale properties of individual amyloid fibrils.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(43):15806-11.
2006: Dumoulin Mireille; Kumita Janet R; Dobson Christopher M
Normal and aberrant biological self-assembly: Insights from studies of human lysozyme and its amyloidogenic variants.
Accounts of chemical research 2006;39(9):603-10.
2006: Vendruscolo Michele; Dobson Christopher M
Structural biology. Dynamic visions of enzymatic reactions.
Science (New York, N.Y.) 2006;313(5793):1586-7.
2006: Squires Adam M; Devlin Glyn L; Gras Sally L; Tickler Anna K; MacPhee Cait E; Dobson Christopher M
X-ray scattering study of the effect of hydration on the cross-beta structure of amyloid fibrils.
Journal of the American Chemical Society 2006;128(36):11738-9.
2006: Baglioni Serena; Casamenti Fiorella; Bucciantini Monica; Luheshi Leila M; Taddei Niccolò; Chiti Fabrizio; Dobson Christopher M; Stefani Massimo
Prefibrillar amyloid aggregates could be generic toxins in higher organisms.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(31):8160-7.
2006: Frare Erica; Mossuto Maria F; Polverino de Laureto Patrizia; Dumoulin Mireille; Dobson Christopher M; Fontana Angelo
Identification of the core structure of lysozyme amyloid fibrils by proteolysis.
Journal of molecular biology 2006;361(3):551-61.
2006: Devlin Glyn L; Knowles Tuomas P J; Squires Adam; McCammon Margaret G; Gras Sally L; Nilsson Melanie R; Robinson Carol V; Dobson Christopher M; MacPhee Cait E
The component polypeptide chains of bovine insulin nucleate or inhibit aggregation of the parent protein in a conformation-dependent manner.
Journal of molecular biology 2006;360(2):497-509.
2006: Bader Reto; Seeliger Markus A; Kelly Sadie E; Ilag Leopold L; Meersman Filip; Limones Alejandra; Luisi Ben F; Dobson Christopher M; Itzhaki Laura S
Folding and fibril formation of the cell cycle protein Cks1.
The Journal of biological chemistry 2006;281(27):18816-24.
2006: Knowles Tuomas P J; Smith Jeffrey F; Craig Aidan; Dobson Christopher M; Welland Mark E
Spatial persistence of angular correlations in amyloid fibrils.
Physical review letters 2006;96(23):238301.
2006: Hall Damien; Dobson Christopher M
Expanding to fill the gap: a possible role for inert biopolymers in regulating the extent of the 'macromolecular crowding' effect.
FEBS letters 2006;580(11):2584-90.
2006: Chandran Vidya; Stollar Elliott J; Lindorff-Larsen Kresten; Harper Jeffrey F; Chazin Walter J; Dobson Christopher M; Luisi Ben F; Christodoulou John
Structure of the regulatory apparatus of a calcium-dependent protein kinase (CDPK): a novel mode of calmodulin-target recognition.
Journal of molecular biology 2006;357(2):400-10.
2006: Meersman Filip; Dobson Christopher M
Probing the pressure-temperature stability of amyloid fibrils provides new insights into their molecular properties.
Biochimica et biophysica acta 2006;1764(3):452-60.
2006: Baldwin Andrew J; Bader Reto; Christodoulou John; MacPhee Cait E; Dobson Christopher M; Barker Paul D
Cytochrome display on amyloid fibrils.
Journal of the American Chemical Society 2006;128(7):2162-3.
2006: Kumita Janet R; Johnson Russell J K; Alcocer Marcos J C; Dumoulin Mireille; Holmqvist Fredrik; McCammon Margaret G; Robinson Carol V; Archer David B; Dobson Christopher M
Impact of the native-state stability of human lysozyme variants on protein secretion by Pichia pastoris.
The FEBS journal 2006;273(4):711-20.
2006: Bader Reto; Bamford Richard; Zurdo Jesús; Luisi Ben F; Dobson Christopher M
Probing the mechanism of amyloidogenesis through a tandem repeat of the PI3-SH3 domain suggests a generic model for protein aggregation and fibril formation.
Journal of molecular biology 2006;356(1):189-208.
2006: Chiti Fabrizio; Dobson Christopher M
Protein misfolding, functional amyloid, and human disease.
Annual review of biochemistry 2006;75():333-66.
2006: Fändrich Marcus; Zandomeneghi Giorgia; Krebs Mark R H; Kittler Marlis; Buder Katrin; Rossner Angela; Heinemann Stefan H; Dobson Christopher M; Diekmann Stephan
Apomyoglobin reveals a random-nucleation mechanism in amyloid protofibril formation.
Acta histochemica 2006;108(3):215-9.
2006: Dobson Christopher M
Protein aggregation and its consequences for human disease.
Protein and peptide letters 2006;13(3):219-27.
2005: Thorn David C; Meehan Sarah; Sunde Margaret; Rekas Agata; Gras Sally L; MacPhee Cait E; Dobson Christopher M; Wilson Mark R; Carver John A
Amyloid fibril formation by bovine milk kappa-casein and its inhibition by the molecular chaperones alphaS- and beta-casein.
Biochemistry 2005;44(51):17027-36.
2005: Wright Caroline F; Teichmann Sarah A; Clarke Jane; Dobson Christopher M
The importance of sequence diversity in the aggregation and evolution of proteins.
Nature 2005;438(7069):878-81.
2005: Calamai Martino; Chiti Fabrizio; Dobson Christopher M
Amyloid fibril formation can proceed from different conformations of a partially unfolded protein.
Biophysical journal 2005;89(6):4201-10.
2005: Collins Emily S; Wirmer Julia; Hirai Kenichi; Tachibana Hideki; Segawa Shin-ichi; Dobson Christopher M; Schwalbe Harald
Characterisation of disulfide-bond dynamics in non-native states of lysozyme and its disulfide deletion mutants by NMR.
Chembiochem : a European journal of chemical biology 2005;6(9):1619-27.
2005: Johnson Russell J K; Christodoulou John; Dumoulin Mireille; Caddy Gemma L; Alcocer Marcos J C; Murtagh Gareth J; Kumita Janet R; Larsson Göran; Robinson Carol V; Archer David B; Luisi Ben; Dobson Christopher M
Rationalising lysozyme amyloidosis: insights from the structure and solution dynamics of T70N lysozyme.
Journal of molecular biology 2005;352(4):823-36.
2005: Salvatella Xavier; Dobson Christopher M; Fersht Alan R; Vendruscolo Michele
Determination of the folding transition states of barnase by using PhiI-value-restrained simulations validated by double mutant PhiIJ-values.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(35):12389-94.
2005: Parrini Claudia; Taddei Niccolò; Ramazzotti Matteo; Degl'Innocenti Donatella; Ramponi Giampietro; Dobson Christopher M; Chiti Fabrizio
Glycine residues appear to be evolutionarily conserved for their ability to inhibit aggregation.
Structure (London, England : 1993) 2005;13(8):1143-51.
2005: Plakoutsi Georgia; Bemporad Francesco; Calamai Martino; Taddei Niccolò; Dobson Christopher M; Chiti Fabrizio
Evidence for a mechanism of amyloid formation involving molecular reorganisation within native-like precursor aggregates.
Journal of molecular biology 2005;351(4):910-22.
2005: Wain Rachel; Smith Lorna J; Dobson Christopher M
Oxidative refolding of amyloidogenic variants of human lysozyme.
Journal of molecular biology 2005;351(3):662-71.
2005: Hall Damien; Hirota Nami; Dobson Christopher M
A toy model for predicting the rate of amyloid formation from unfolded protein.
Journal of molecular biology 2005;351(1):195-205.
2005: Carulla Natàlia; Caddy Gemma L; Hall Damien R; Zurdo Jesús; Gairí Margarida; Feliz Miguel; Giralt Ernest; Robinson Carol V; Dobson Christopher M
Molecular recycling within amyloid fibrils.
Nature 2005;436(7050):554-8.
2005: Fowler Susan B; Poon Stephen; Muff Roman; Chiti Fabrizio; Dobson Christopher M; Zurdo Jesús
Rational design of aggregation-resistant bioactive peptides: reengineering human calcitonin.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(29):10105-10.
2005: Pawar Amol P; Dubay Kateri F; Zurdo Jesús; Chiti Fabrizio; Vendruscolo Michele; Dobson Christopher M
Prediction of "aggregation-prone" and "aggregation-susceptible" regions in proteins associated with neurodegenerative diseases.
Journal of molecular biology 2005;350(2):379-92.
2005: Mok K Hun; Nagashima Toshio; Day Iain J; Hore P J; Dobson Christopher M
Multiple subsets of side-chain packing in partially folded states of alpha-lactalbumins.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(25):8899-904.
2005: Vendruscolo Michele; Dobson Christopher M
A glimpse at the organization of the protein universe.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(16):5641-2.
2005: Kristjansdottir Sigridur; Lindorff-Larsen Kresten; Fieber Wolfgang; Dobson Christopher M; Vendruscolo Michele; Poulsen Flemming M
Formation of native and non-native interactions in ensembles of denatured ACBP molecules from paramagnetic relaxation enhancement studies.
Journal of molecular biology 2005;347(5):1053-62.
2005: Dedmon Matthew M; Christodoulou John; Wilson Mark R; Dobson Christopher M
Heat shock protein 70 inhibits alpha-synuclein fibril formation via preferential binding to prefibrillar species.
The Journal of biological chemistry 2005;280(15):14733-40.
2005: Marcon Giordana; Plakoutsi Georgia; Canale Claudio; Relini Annalisa; Taddei Niccolò; Dobson Christopher M; Ramponi Giampietro; Chiti Fabrizio
Amyloid formation from HypF-N under conditions in which the protein is initially in its native state.
Journal of molecular biology 2005;347(2):323-35.
2005: Calloni Giulia; Zoffoli Sara; Stefani Massimo; Dobson Christopher M; Chiti Fabrizio
Investigating the effects of mutations on protein aggregation in the cell.
The Journal of biological chemistry 2005;280(11):10607-13.
2005: Dumoulin Mireille; Canet Denis; Last Alexander M; Pardon Els; Archer David B; Muyldermans Serge; Wyns Lode; Matagne Andre; Robinson Carol V; Redfield Christina; Dobson Christopher M
Reduced global cooperativity is a common feature underlying the amyloidogenicity of pathogenic lysozyme mutations.
Journal of molecular biology 2005;346(3):773-88.
2005: Calamai Martino; Canale Claudio; Relini Annalisa; Stefani Massimo; Chiti Fabrizio; Dobson Christopher M
Reversal of protein aggregation provides evidence for multiple aggregated States.
Journal of molecular biology 2005;346(2):603-16.
2005: Vendruscolo Michele; Dobson Christopher M
Towards complete descriptions of the free-energy landscapes of proteins.
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences 2005;363(1827):433-50; discussion 450-2.
2005: Lindorff-Larsen Kresten; Røgen Peter; Paci Emanuele; Vendruscolo Michele; Dobson Christopher M
Protein folding and the organization of the protein topology universe.
Trends in biochemical sciences 2005;30(1):13-9.
2005: Lindorff-Larsen Kresten; Best Robert B; Depristo Mark A; Dobson Christopher M; Vendruscolo Michele
Simultaneous determination of protein structure and dynamics.
Nature 2005;433(7022):128-32.
2005: Dedmon Matthew M; Lindorff-Larsen Kresten; Christodoulou John; Vendruscolo Michele; Dobson Christopher M
Mapping long-range interactions in alpha-synuclein using spin-label NMR and ensemble molecular dynamics simulations.
Journal of the American Chemical Society 2005;127(2):476-7.
2004: Dobson Christopher M
Chemical space and biology.
Nature 2004;432(7019):824-8.
2004: Krebs Mark R H; Macphee Cait E; Miller Aline F; Dunlop Iain E; Dobson Christopher M; Donald Athene M
The formation of spherulites by amyloid fibrils of bovine insulin.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(40):14420-4.
2004: Dumoulin Mireille; Dobson Christopher M
Probing the origins, diagnosis and treatment of amyloid diseases using antibodies.
Biochimie 2004;86(9-10):589-600.
2004: Dobson Christopher M
Experimental investigation of protein folding and misfolding.
Methods (San Diego, Calif.) 2004;34(1):4-14.
2004: DuBay Kateri F; Pawar Amol P; Chiti Fabrizio; Zurdo Jesús; Dobson Christopher M; Vendruscolo Michele
Prediction of the absolute aggregation rates of amyloidogenic polypeptide chains.
Journal of molecular biology 2004;341(5):1317-26.
2004: Korzhnev Dmitry M; Salvatella Xavier; Vendruscolo Michele; Di Nardo Ariel A; Davidson Alan R; Dobson Christopher M; Kay Lewis E
Low-populated folding intermediates of Fyn SH3 characterized by relaxation dispersion NMR.
Nature 2004;430(6999):586-90.
2004: Christodoulou John; Larsson Göran; Fucini Paola; Connell Sean R; Pertinhez Thelma A; Hanson Charlotte L; Redfield Christina; Nierhaus Knud H; Robinson Carol V; Schleucher Jürgen; Dobson Christopher M
Heteronuclear NMR investigations of dynamic regions of intact Escherichia coli ribosomes.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(30):10949-54.
2004: Frare Erica; Polverino De Laureto Patrizia; Zurdo Jesús; Dobson Christopher M; Fontana Angelo
A highly amyloidogenic region of hen lysozyme.
Journal of molecular biology 2004;340(5):1153-65.
2004: Krebs Mark R H; Morozova-Roche Ludmilla A; Daniel Katie; Robinson Carol V; Dobson Christopher M
Observation of sequence specificity in the seeding of protein amyloid fibrils.
Protein science : a publication of the Protein Society 2004;13(7):1933-8.
2004: Bucciantini Monica; Calloni Giulia; Chiti Fabrizio; Formigli Lucia; Nosi Daniele; Dobson Christopher M; Stefani Massimo
Prefibrillar amyloid protein aggregates share common features of cytotoxicity.
The Journal of biological chemistry 2004;279(30):31374-82.
2004: Wright Caroline F; Christodoulou John; Dobson Christopher M; Clarke Jane
The importance of loop length in the folding of an immunoglobulin domain.
Protein engineering, design & selection : PEDS 2004;17(5):443-53.
2004: Dobson Christopher M
Protein chemistry. In the footsteps of alchemists.
Science (New York, N.Y.) 2004;304(5675):1259-62.
2004: Lindorff-Larsen Kresten; Vendruscolo Michele; Paci Emanuele; Dobson Christopher M
Transition states for protein folding have native topologies despite high structural variability.
Nature structural & molecular biology 2004;11(5):443-9.
2004: Gilbert Robert J C; Fucini Paola; Connell Sean; Fuller Stephen D; Nierhaus Knud H; Robinson Carol V; Dobson Christopher M; Stuart David I
Three-dimensional structures of translating ribosomes by Cryo-EM.
Molecular cell 2004;14(1):57-66.
2004: Quezada Cindy M; Schulman Brenda A; Froggatt Joanna J; Dobson Christopher M; Redfield Christina
Local and global cooperativity in the human alpha-lactalbumin molten globule.
Journal of molecular biology 2004;338(1):149-58.
2004: Lindorff-Larsen Kresten; Kristjansdottir Sigridur; Teilum Kaare; Fieber Wolfgang; Dobson Christopher M; Poulsen Flemming M; Vendruscolo Michele
Determination of an ensemble of structures representing the denatured state of the bovine acyl-coenzyme a binding protein.
Journal of the American Chemical Society 2004;126(10):3291-9.
2004: Dobson Christopher M
Principles of protein folding, misfolding and aggregation.
Seminars in cell & developmental biology 2004;15(1):3-16.
2004: Jaroniec Christopher P; MacPhee Cait E; Bajaj Vikram S; McMahon Michael T; Dobson Christopher M; Griffin Robert G
High-resolution molecular structure of a peptide in an amyloid fibril determined by magic angle spinning NMR spectroscopy.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(3):711-6.
2004: Meehan Sarah; Berry Yoke; Luisi Ben; Dobson Christopher M; Carver John A; MacPhee Cait E
Amyloid fibril formation by lens crystallin proteins and its implications for cataract formation.
The Journal of biological chemistry 2004;279(5):3413-9.
2003: Dobson Christopher M
Protein folding and misfolding.
Nature 2003;426(6968):884-90.
2003: Vendruscolo Michele; Paci Emanuele; Dobson Christopher M; Karplus Martin
Rare fluctuations of native proteins sampled by equilibrium hydrogen exchange.
Journal of the American Chemical Society 2003;125(51):15686-7.
2003: Fändrich Marcus; Forge Vincent; Buder Katrin; Kittler Marlis; Dobson Christopher M; Diekmann Stephan
Myoglobin forms amyloid fibrils by association of unfolded polypeptide segments.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(26):15463-8.
2003: Vendruscolo Michele; Paci Emanuele; Karplus Martin; Dobson Christopher M
Structures and relative free energies of partially folded states of proteins.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(25):14817-21.
2003: Polverino de Laureto Patrizia; Taddei Niccolò; Frare Erica; Capanni Cristina; Costantini Silvia; Zurdo Jesús; Chiti Fabrizio; Dobson Christopher M; Fontana Angelo
Protein aggregation and amyloid fibril formation by an SH3 domain probed by limited proteolysis.
Journal of molecular biology 2003;334(1):129-41.
2003: Nilsson Melanie R; Dobson Christopher M
Chemical modification of insulin in amyloid fibrils.
Protein science : a publication of the Protein Society 2003;12(11):2637-41.
2003: Stefani Massimo; Dobson Christopher M
Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution.
Journal of molecular medicine (Berlin, Germany) 2003;81(11):678-99.
2003: Mok K Hun; Nagashima Toshio; Day Iain J; Jones Jonathan A; Jones Charles J V; Dobson Christopher M; Hore P J
Rapid sample-mixing technique for transient NMR and photo-CIDNP spectroscopy: applications to real-time protein folding.
Journal of the American Chemical Society 2003;125(41):12484-92.
2003: Chiti Fabrizio; Stefani Massimo; Taddei Niccolò; Ramponi Giampietro; Dobson Christopher M
Rationalization of the effects of mutations on peptide and protein aggregation rates.
Nature 2003;424(6950):805-8.
2003: Dumoulin Mireille; Last Alexander M; Desmyter Aline; Decanniere Klaas; Canet Denis; Larsson Göran; Spencer Andrew; Archer David B; Sasse Jurgen; Muyldermans Serge; Wyns Lode; Redfield Christina; Matagne André; Robinson Carol V; Dobson Christopher M
A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme.
Nature 2003;424(6950):783-8.
2003: Lindorff-Larsen Kresten; Paci Emanuele; Serrano Luis; Dobson Christopher M; Vendruscolo Michele
Calculation of mutational free energy changes in transition states for protein folding.
Biophysical journal 2003;85(2):1207-14.
2003: Malisauskas Mantas; Zamotin Vladimir; Jass Jana; Noppe Wim; Dobson Christopher M; Morozova-Roche Ludmilla A
Amyloid protofilaments from the calcium-binding protein equine lysozyme: formation of ring and linear structures depends on pH and metal ion concentration.
Journal of molecular biology 2003;330(4):879-90.
2003: Canet Denis; Lyon Charles E; Scheek Ruud M; Robillard George T; Dobson Christopher M; Hore Peter J; van Nuland Nico A J
Rapid formation of non-native contacts during the folding of HPr revealed by real-time photo-CIDNP NMR and stopped-flow fluorescence experiments.
Journal of molecular biology 2003;330(2):397-407.
2003: Vendruscolo Michele; Zurdo Jesús; MacPhee Cait E; Dobson Christopher M
Protein folding and misfolding: a paradigm of self-assembly and regulation in complex biological systems.
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences 2003;361(1807):1205-22.
2003: Azuaga Ana I; Canet Denis; Smeenk Gerard; Berends Roel; Titgemeijer Fritz; Duurkens Ria; Mateo Pedro L; Scheek Ruud M; Robillard George T; Dobson Christopher M; van Nuland Nico A J
Characterization of single-tryptophan mutants of histidine-containing phosphocarrier protein: evidence for local rearrangements during folding from high concentrations of denaturant.
Biochemistry 2003;42(17):4883-95.
2003: Kamatari Yuji O; Dobson Christopher M; Konno Takashi
Structural dissection of alkaline-denatured pepsin.
Protein science : a publication of the Protein Society 2003;12(4):717-24.
2003: Dobson Christopher M
Protein folding and disease: a view from the first Horizon Symposium.
Nature reviews. Drug discovery 2003;2(2):154-60.
2003: Nilsson Melanie R; Dobson Christopher M
In vitro characterization of lactoferrin aggregation and amyloid formation.
Biochemistry 2003;42(2):375-82.
2002: Jaroniec Christopher P; MacPhee Cait E; Astrof Nathan S; Dobson Christopher M; Griffin Robert G
Molecular conformation of a peptide fragment of transthyretin in an amyloid fibril.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(26):16748-53.
2002: Chiti Fabrizio; Calamai Martino; Taddei Niccolo; Stefani Massimo; Ramponi Giampietro; Dobson Christopher M
Studies of the aggregation of mutant proteins in vitro provide insights into the genetics of amyloid diseases.
Proceedings of the National Academy of Sciences of the United States of America 2002;99 Suppl 4():16419-26.
2002: Fändrich Marcus; Dobson Christopher M
The behaviour of polyamino acids reveals an inverse side chain effect in amyloid structure formation.
The EMBO journal 2002;21(21):5682-90.
2002: Lyon Charles E; Suh Eui-Sik; Dobson Christopher M; Hore P J
Probing the exposure of tyrosine and tryptophan residues in partially folded proteins and folding intermediates by CIDNP pulse-labeling.
Journal of the American Chemical Society 2002;124(44):13018-24.
2002: Pertinhez Thelma A; Bouchard Mario; Smith Richard A G; Dobson Christopher M; Smith Lorna J
Stimulation and inhibition of fibril formation by a peptide in the presence of different concentrations of SDS.
FEBS letters 2002;529(2-3):193-7.
2002: Dobson Christopher M
Getting out of shape.
Nature 2002;418(6899):729-30.
2002: Azuaga Ana I; Dobson Christopher M; Mateo Pedro L; Conejero-Lara Francisco
Unfolding and aggregation during the thermal denaturation of streptokinase.
European journal of biochemistry / FEBS 2002;269(16):4121-33.
2002: Jiménez José L; Nettleton Ewan J; Bouchard Mario; Robinson Carol V; Dobson Christopher M; Saibil Helen R
The protofilament structure of insulin amyloid fibrils.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(14):9196-201.
2002: Carver John A; Lindner Robyn A; Lyon Charles; Canet Denis; Hernandez Helena; Dobson Christopher M; Redfield Christina
The interaction of the molecular chaperone alpha-crystallin with unfolding alpha-lactalbumin: a structural and kinetic spectroscopic study.
Journal of molecular biology 2002;318(3):815-27.
2002: Canet Denis; Last Alexander M; Tito Paula; Sunde Margaret; Spencer Andrew; Archer David B; Redfield Christina; Robinson Carol V; Dobson Christopher M
Local cooperativity in the unfolding of an amyloidogenic variant of human lysozyme.
Nature structural biology 2002;9(4):308-15.
2002: Klein-Seetharaman Judith; Oikawa Maki; Grimshaw Shaun B; Wirmer Julia; Duchardt Elke; Ueda Tadashi; Imoto Taiji; Smith Lorna J; Dobson Christopher M; Schwalbe Harald
Long-range interactions within a nonnative protein.
Science (New York, N.Y.) 2002;295(5560):1719-22.
2002: Chiti Fabrizio; Taddei Niccolò; Baroni Fabiana; Capanni Cristina; Stefani Massimo; Ramponi Giampietro; Dobson Christopher M
Kinetic partitioning of protein folding and aggregation.
Nature structural biology 2002;9(2):137-43.
2001: Chiti F; Bucciantini M; Capanni C; Taddei N; Dobson C M; Stefani M
Solution conditions can promote formation of either amyloid protofilaments or mature fibrils from the HypF N-terminal domain.
Protein science : a publication of the Protein Society 2001;10(12):2541-7.
2001: Chamberlain A K; Receveur V; Spencer A; Redfield C; Dobson C M
Characterization of the structure and dynamics of amyloidogenic variants of human lysozyme by NMR spectroscopy.
Protein science : a publication of the Protein Society 2001;10(12):2525-30.
2001: Chiti F; De Lorenzi E; Grossi S; Mangione P; Giorgetti S; Caccialanza G; Dobson C M; Merlini G; Ramponi G; Bellotti V
A partially structured species of beta 2-microglobulin is significantly populated under physiological conditions and involved in fibrillogenesis.
The Journal of biological chemistry 2001;276(50):46714-21.
2001: Wain R; Pertinhez T A; Tomlinson E J; Hong L; Dobson C M; Ferguson S J; Smith L J
The cytochrome c fold can be attained from a compact apo state by occupancy of a nascent heme binding site.
The Journal of biological chemistry 2001;276(49):45813-7.
2001: Taddei N; Capanni C; Chiti F; Stefani M; Dobson C M; Ramponi G
Folding and aggregation are selectively influenced by the conformational preferences of the alpha-helices of muscle acylphosphatase.
The Journal of biological chemistry 2001;276(40):37149-54.
2001: Wijesinha-Bettoni R; Dobson C M; Redfield C
Comparison of the denaturant-induced unfolding of the bovine and human alpha-lactalbumin molten globules.
Journal of molecular biology 2001;312(1):261-73.
2001: Zurdo J; Guijarro J I; Dobson C M
Preparation and characterization of purified amyloid fibrils.
Journal of the American Chemical Society 2001;123(33):8141-2.
2001: Zurdo J; Guijarro J I; Jiménez J L; Saibil H R; Dobson C M
Dependence on solution conditions of aggregation and amyloid formation by an SH3 domain.
Journal of molecular biology 2001;311(2):325-40.
2001: Pertinhez T A; Bouchard M; Tomlinson E J; Wain R; Ferguson S J; Dobson C M; Smith L J
Amyloid fibril formation by a helical cytochrome.
FEBS letters 2001;495(3):184-6.
2001: Chiti F; Taddei N; Stefani M; Dobson C M; Ramponi G
Reduction of the amyloidogenicity of a protein by specific binding of ligands to the native conformation.
Protein science : a publication of the Protein Society 2001;10(4):879-86.
2001: Schwalbe H; Grimshaw S B; Spencer A; Buck M; Boyd J; Dobson C M; Redfield C; Smith L J
A refined solution structure of hen lysozyme determined using residual dipolar coupling data.
Protein science : a publication of the Protein Society 2001;10(4):677-88.
2001: Canet D; Doering K; Dobson C M; Dupont Y
High-sensitivity fluorescence anisotropy detection of protein-folding events: application to alpha-lactalbumin.
Biophysical journal 2001;80(4):1996-2003.
2001: Wijesinha-Bettoni R; Dobson C M; Redfield C
Comparison of the structural and dynamical properties of holo and apo bovine alpha-lactalbumin by NMR spectroscopy.
Journal of molecular biology 2001;307(3):885-98.
2001: Kamatari Y O; Yamada H; Akasaka K; Jones J A; Dobson C M; Smith L J
Response of native and denatured hen lysozyme to high pressure studied by (15)N/(1)H NMR spectroscopy.
European journal of biochemistry / FEBS 2001;268(6):1782-93.
2001: Chiti F; Mangione P; Andreola A; Giorgetti S; Stefani M; Dobson C M; Bellotti V; Taddei N
Detection of two partially structured species in the folding process of the amyloidogenic protein beta 2-microglobulin.
Journal of molecular biology 2001;307(1):379-91.
2001: Fändrich M; Fletcher M A; Dobson C M
Amyloid fibrils from muscle myoglobin.
Nature 2001;410(6825):165-6.
2001: Paci E; Smith L J; Dobson C M; Karplus M
Exploration of partially unfolded states of human alpha-lactalbumin by molecular dynamics simulation.
Journal of molecular biology 2001;306(2):329-47.
2001: Vendruscolo M; Paci E; Dobson C M; Karplus M
Three key residues form a critical contact network in a protein folding transition state.
Nature 2001;409(6820):641-5.
2000: Chamberlain A K; MacPhee C E; Zurdo J; Morozova-Roche L A; Hill H A; Dobson C M; Davis J J
Ultrastructural organization of amyloid fibrils by atomic force microscopy.
Biophysical journal 2000;79(6):3282-93.
2000: Fändrich M; Tito M A; Leroux M R; Rostom A A; Hartl F U; Dobson C M; Robinson C V
Observation of the noncovalent assembly and disassembly pathways of the chaperone complex MtGimC by mass spectrometry.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(26):14151-5.
2000: Bouchard M; Zurdo J; Nettleton E J; Dobson C M; Robinson C V
Formation of insulin amyloid fibrils followed by FTIR simultaneously with CD and electron microscopy.
Protein science : a publication of the Protein Society 2000;9(10):1960-7.
2000: Dobson C M; Ellison G B; Tuck A F; Vaida V
Atmospheric aerosols as prebiotic chemical reactors.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):11864-8.
2000: Pertinhez T A; Hamada D; Smith L J; Chiti F; Taddei N; Stefani M; Dobson C M
Initial denaturing conditions influence the slow folding phase of acylphosphatase associated with proline isomerization.
Protein science : a publication of the Protein Society 2000;9(8):1466-73.
2000: van den Berg B; Wain R; Dobson C M; Ellis R J
Macromolecular crowding perturbs protein refolding kinetics: implications for folding inside the cell.
The EMBO journal 2000;19(15):3870-5.
2000: Nettleton E J; Tito P; Sunde M; Bouchard M; Dobson C M; Robinson C V
Characterization of the oligomeric states of insulin in self-assembly and amyloid fibril formation by mass spectrometry.
Biophysical journal 2000;79(2):1053-65.
2000: Taddei N; Chiti F; Fiaschi T; Bucciantini M; Capanni C; Stefani M; Serrano L; Dobson C M; Ramponi G
Stabilisation of alpha-helices by site-directed mutagenesis reveals the importance of secondary structure in the transition state for acylphosphatase folding.
Journal of molecular biology 2000;300(3):633-47.
2000: Krebs M R; Wilkins D K; Chung E W; Pitkeathly M C; Chamberlain A K; Zurdo J; Robinson C V; Dobson C M
Formation and seeding of amyloid fibrils from wild-type hen lysozyme and a peptide fragment from the beta-domain.
Journal of molecular biology 2000;300(3):541-9.
2000: Dinner A R; Sali A; Smith L J; Dobson C M; Karplus M
Understanding protein folding via free-energy surfaces from theory and experiment.
Trends in biochemical sciences 2000;25(7):331-9.
2000: Morozova-Roche L A; Zurdo J; Spencer A; Noppe W; Receveur V; Archer D B; Joniau M; Dobson C M
Amyloid fibril formation and seeding by wild-type human lysozyme and its disease-related mutational variants.
Journal of structural biology 2000;130(2-3):339-51.
2000: Morgan C J; Wilkins D K; Smith L J; Kawata Y; Dobson C M
A compact monomeric intermediate identified by NMR in the denaturation of dimeric triose phosphate isomerase.
Journal of molecular biology 2000;300(1):11-6.
2000: Rostom A A; Fucini P; Benjamin D R; Juenemann R; Nierhaus K H; Hartl F U; Dobson C M; Robinson C V
Detection and selective dissociation of intact ribosomes in a mass spectrometer.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5185-90.
2000: Wilkins D K; Dobson C M; Gross M
Biophysical studies of the development of amyloid fibrils from a peptide fragment of cold shock protein B.
European journal of biochemistry / FEBS 2000;267(9):2609-16.
2000: MacPhee C E; Dobson C M
Chemical dissection and reassembly of amyloid fibrils formed by a peptide fragment of transthyretin.
Journal of molecular biology 2000;297(5):1203-15.
2000: Chiti F; Taddei N; Bucciantini M; White P; Ramponi G; Dobson C M
Mutational analysis of the propensity for amyloid formation by a globular protein.
The EMBO journal 2000;19(7):1441-9.
2000: Maeda K; Lyon C E; Lopez J J; Cemazar M; Dobson C M; Hore P J
Improved photo-CIDNP methods for studying protein structure and folding.
Journal of biomolecular NMR 2000;16(3):235-44.
2000: Penkett C J; Dobson C M; Smith L J; Bright J R; Pickford A R; Campbell I D; Potts J R
Identification of residues involved in the interaction of Staphylococcus aureus fibronectin-binding protein with the (4)F1(5)F1 module pair of human fibronectin using heteronuclear NMR spectroscopy.
Biochemistry 2000;39(11):2887-93.
2000: Matagne A; Jamin M; Chung E W; Robinson C V; Radford S E; Dobson C M
Thermal unfolding of an intermediate is associated with non-Arrhenius kinetics in the folding of hen lysozyme.
Journal of molecular biology 2000;297(1):193-210.
2000: Bouchard M; Benjamin D R; Tito P; Robinson C V; Dobson C M
Solvent effects on the conformation of the transmembrane peptide gramicidin A: insights from electrospray ionization mass spectrometry.
Biophysical journal 2000;78(2):1010-7.
2000: Hamada D; Chiti F; Guijarro J I; Kataoka M; Taddei N; Dobson C M
Evidence concerning rate-limiting steps in protein folding from the effects of trifluoroethanol.
Nature structural biology 2000;7(1):58-61.
1999: van den Berg B; Ellis R J; Dobson C M
Effects of macromolecular crowding on protein folding and aggregation.
The EMBO journal 1999;18(24):6927-33.
1999: Wilkins D K; Grimshaw S B; Receveur V; Dobson C M; Jones J A; Smith L J
Hydrodynamic radii of native and denatured proteins measured by pulse field gradient NMR techniques.
Biochemistry 1999;38(50):16424-31.
1999: Leroux M R; Fändrich M; Klunker D; Siegers K; Lupas A N; Brown J R; Schiebel E; Dobson C M; Hartl F U
MtGimC, a novel archaeal chaperone related to the eukaryotic chaperonin cofactor GimC/prefoldin.
The EMBO journal 1999;18(23):6730-43.
1999: Chiti F; Taddei N; White P M; Bucciantini M; Magherini F; Stefani M; Dobson C M
Mutational analysis of acylphosphatase suggests the importance of topology and contact order in protein folding.
Nature structural biology 1999;6(11):1005-9.
1999: Redfield C; Schulman B A; Milhollen M A; Kim P S; Dobson C M
Alpha-lactalbumin forms a compact molten globule in the absence of disulfide bonds.
Nature structural biology 1999;6(10):948-52.
1999: Dobson C M
Protein misfolding, evolution and disease.
Trends in biochemical sciences 1999;24(9):329-32.
1999: van den Berg B; Chung E W; Robinson C V; Mateo P L; Dobson C M
The oxidative refolding of hen lysozyme and its catalysis by protein disulfide isomerase.
The EMBO journal 1999;18(17):4794-803.
1999: Chiti F; Taddei N; Giannoni E; van Nuland N A; Ramponi G; Dobson C M
Development of enzymatic activity during protein folding. Detection of a spectroscopically silent native-like intermediate of muscle acylphosphatase.
The Journal of biological chemistry 1999;274(29):20151-8.
1999: van den Berg B; Chung E W; Robinson C V; Dobson C M
Characterisation of the dominant oxidative folding intermediate of hen lysozyme.
Journal of molecular biology 1999;290(3):781-96.
1999: Smith L J; Dobson C M; van Gunsteren W F
Molecular dynamics simulations of human alpha-lactalbumin: changes to the structural and dynamical properties of the protein at low pH.
Proteins 1999;36(1):77-86.
1999: Vis H; Dobson C M; Robinson C V
Selective association of protein molecules followed by mass spectrometry.
Protein science : a publication of the Protein Society 1999;8(6):1368-70.
1999: Gross M; Wilkins D K; Pitkeathly M C; Chung E W; Higham C; Clark A; Dobson C M
Formation of amyloid fibrils by peptides derived from the bacterial cold shock protein CspB.
Protein science : a publication of the Protein Society 1999;8(6):1350-7.
1999: Morozova-Roche L A; Jones J A; Noppe W; Dobson C M
Independent nucleation and heterogeneous assembly of structure during folding of equine lysozyme.
Journal of molecular biology 1999;289(4):1055-73.
1999: Spencer A; Morozov-Roche L A; Noppe W; MacKenzie D A; Jeenes D J; Joniau M; Dobson C M; Archer D B
Expression, purification, and characterization of the recombinant calcium-binding equine lysozyme secreted by the filamentous fungus Aspergillus niger: comparisons with the production of hen and human lysozymes.
Protein expression and purification 1999;16(1):171-80.
1999: Canet D; Sunde M; Last A M; Miranker A; Spencer A; Robinson C V; Dobson C M
Mechanistic studies of the folding of human lysozyme and the origin of amyloidogenic behavior in its disease-related variants.
Biochemistry 1999;38(20):6419-27.
1999: Hennig M; Bermel W; Spencer A; Dobson C M; Smith L J; Schwalbe H
Side-chain conformations in an unfolded protein: chi1 distributions in denatured hen lysozyme determined by heteronuclear 13C, 15N NMR spectroscopy.
Journal of molecular biology 1999;288(4):705-23.
1999: Forge V; Wijesinha R T; Balbach J; Brew K; Robinson C V; Redfield C; Dobson C M
Rapid collapse and slow structural reorganisation during the refolding of bovine alpha-lactalbumin.
Journal of molecular biology 1999;288(4):673-88.
1999: Chiti F; Taddei N; Webster P; Hamada D; Fiaschi T; Ramponi G; Dobson C M
Acceleration of the folding of acylphosphatase by stabilization of local secondary structure.
Nature structural biology 1999;6(4):380-7.
1999: Chiti F; Webster P; Taddei N; Clark A; Stefani M; Ramponi G; Dobson C M
Designing conditions for in vitro formation of amyloid protofilaments and fibrils.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):3590-4.
1999: Smith L J; Dobson C M; van Gunsteren W F
Side-chain conformational disorder in a molten globule: molecular dynamics simulations of the A-state of human alpha-lactalbumin.
Journal of molecular biology 1999;286(5):1567-80.
1999: Azuaga A I; Woodruff N D; Conejero-Lara F; Cox V F; Smith R A; Dobson C M
Expression and characterization of the intact N-terminal domain of streptokinase.
Protein science : a publication of the Protein Society 1999;8(2):443-6.
1999: Dobson C M; Karplus M
The fundamentals of protein folding: bringing together theory and experiment.
Current opinion in structural biology 1999;9(1):92-101.
1999: Taddei N; Chiti F; Paoli P; Fiaschi T; Bucciantini M; Stefani M; Dobson C M; Ramponi G
Thermodynamics and kinetics of folding of common-type acylphosphatase: comparison to the highly homologous muscle isoenzyme.
Biochemistry 1999;38(7):2135-42.
1999: Jiménez J L; Guijarro J I; Orlova E; Zurdo J; Dobson C M; Sunde M; Saibil H R
Cryo-electron microscopy structure of an SH3 amyloid fibril and model of the molecular packing.
The EMBO journal 1999;18(4):815-21.
1998: Penkett C J; Redfield C; Jones J A; Dodd I; Hubbard J; Smith R A; Smith L J; Dobson C M
Structural and dynamical characterization of a biologically active unfolded fibronectin-binding protein from Staphylococcus aureus.
Biochemistry 1998;37(48):17054-67.
1998: Chiti F; Taddei N; van Nuland N A; Magherini F; Stefani M; Ramponi G; Dobson C M
Structural characterization of the transition state for folding of muscle acylphosphatase.
Journal of molecular biology 1998;283(4):893-903.
1998: van Nuland N A; Chiti F; Taddei N; Raugei G; Ramponi G; Dobson C M
Slow folding of muscle acylphosphatase in the absence of intermediates.
Journal of molecular biology 1998;283(4):883-91.
1998: Conejero-Lara F; Parrado J; Azuaga A I; Dobson C M; Ponting C P
Analysis of the interactions between streptokinase domains and human plasminogen.
Protein science : a publication of the Protein Society 1998;7(10):2190-9.
1998: Dobson C M; Ellis R J
Protein folding and misfolding inside and outside the cell.
The EMBO journal 1998;17(18):5251-4.
1998: Nettleton E J; Sunde M; Lai Z; Kelly J W; Dobson C M; Robinson C V
Protein subunit interactions and structural integrity of amyloidogenic transthyretins: evidence from electrospray mass spectrometry.
Journal of molecular biology 1998;281(3):553-64.
1998: Chiti F; Magherini F; Taddei N; Ilardi C; Stefani M; Bucciantini M; Dobson C M; Ramponi G
Studies on enzymatic activity and conformational stability of muscle acylphosphatase mutated at conserved lysine residues.
Protein engineering 1998;11(7):557-61.
1998: Smith L J; Mark A E; Dobson C M; van Gunsteren W F
Molecular dynamics simulations of peptide fragments from hen lysozyme: insight into non-native protein conformations.
Journal of molecular biology 1998;280(4):703-19.
1998: Dobson C M; Hore P J
Kinetic studies of protein folding using NMR spectroscopy.
Nature structural biology 1998;5 Suppl():504-7.
1998: Benjamin D R; Robinson C V; Hendrick J P; Hartl F U; Dobson C M
Mass spectrometry of ribosomes and ribosomal subunits.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(13):7391-5.
1998: Morgan C J; Miranker A; Dobson C M
Characterization of collapsed states in the early stages of the refolding of hen lysozyme.
Biochemistry 1998;37(23):8473-80.
1998: Matagne A; Dobson C M
The folding process of hen lysozyme: a perspective from the 'new view'.
Cellular and molecular life sciences : CMLS 1998;54(4):363-71.
1998: Matagne A; Chung E W; Ball L J; Radford S E; Robinson C V; Dobson C M
The origin of the alpha-domain intermediate in the folding of hen lysozyme.
Journal of molecular biology 1998;277(5):997-1005.
1998: Guijarro J I; Sunde M; Jones J A; Campbell I D; Dobson C M
Amyloid fibril formation by an SH3 domain.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(8):4224-8.
1998: de Jongh H H; Rospert S; Dobson C M
Comparison of the conformational state and in vitro refolding of yeast chaperonin protein cpn10 with bacterial GroES.
Biochemical and biophysical research communications 1998;244(3):884-8.
1998: Guijarro J I; Morton C J; Plaxco K W; Campbell I D; Dobson C M
Folding kinetics of the SH3 domain of PI3 kinase by real-time NMR combined with optical spectroscopy.
Journal of molecular biology 1998;276(3):657-67.
1998: Plaxco K W; Guijarro J I; Morton C J; Pitkeathly M; Campbell I D; Dobson C M
The folding kinetics and thermodynamics of the Fyn-SH3 domain.
Biochemistry 1998;37(8):2529-37.
1998: Chiti F; van Nuland N A; Taddei N; Magherini F; Stefani M; Ramponi G; Dobson C M
Conformational stability of muscle acylphosphatase: the role of temperature, denaturant concentration, and pH.
Biochemistry 1998;37(5):1447-55.
1998: Van Nuland N A; Meijberg W; Warner J; Forge V; Scheek R M; Robillard G T; Dobson C M
Slow cooperative folding of a small globular protein HPr.
Biochemistry 1998;37(2):622-37.
1998: Rostom A A; Sunde M; Richardson S J; Schreiber G; Jarvis S; Bateman R; Dobson C M; Robinson C V
Dissection of multi-protein complexes using mass spectrometry: subunit interactions in transthyretin and retinol-binding protein complexes.
Proteins 1998;Suppl 2():3-11.
1997: Penkett C J; Redfield C; Dodd I; Hubbard J; McBay D L; Mossakowska D E; Smith R A; Dobson C M; Smith L J
NMR analysis of main-chain conformational preferences in an unfolded fibronectin-binding protein.
Journal of molecular biology 1997;274(2):152-9.
1997: Schulman B A; Kim P S; Dobson C M; Redfield C
A residue-specific NMR view of the non-cooperative unfolding of a molten globule.
Nature structural biology 1997;4(8):630-4.
1997: Plaxco K W; Spitzfaden C; Campbell I D; Dobson C M
A comparison of the folding kinetics and thermodynamics of two homologous fibronectin type III modules.
Journal of molecular biology 1997;270(5):763-70.
1997: Schwalbe H; Fiebig K M; Buck M; Jones J A; Grimshaw S B; Spencer A; Glaser S J; Smith L J; Dobson C M
Structural and dynamical properties of a denatured protein. Heteronuclear 3D NMR experiments and theoretical simulations of lysozyme in 8 M urea.
Biochemistry 1997;36(29):8977-91.
1997: Balbach J; Forge V; Lau W S; Jones J A; van Nuland N A; Dobson C M
Detection of residue contacts in a protein folding intermediate.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(14):7182-5.
1997: Chung E W; Nettleton E J; Morgan C J; Gross M; Miranker A; Radford S E; Dobson C M; Robinson C V
Hydrogen exchange properties of proteins in native and denatured states monitored by mass spectrometry and NMR.
Protein science : a publication of the Protein Society 1997;6(6):1316-24.
1997: Morozova-Roche L A; Arico-Muendel C C; Haynie D T; Emelyanenko V I; Van Dael H; Dobson C M
Structural characterisation and comparison of the native and A-states of equine lysozyme.
Journal of molecular biology 1997;268(5):903-21.
1997: Matagne A; Radford S E; Dobson C M
Fast and slow tracks in lysozyme folding: insight into the role of domains in the folding process.
Journal of molecular biology 1997;267(5):1068-74.
1997: Dobson C M; Ptitsyn O B
Folding and binding. From theory to therapy.
Current opinion in structural biology 1997;7(1):1-2.
1997: Lu H; Buck M; Radford S E; Dobson C M
Acceleration of the folding of hen lysozyme by trifluoroethanol.
Journal of molecular biology 1997;265(2):112-7.
1996: Conejero-Lara F; Parrado J; Azuaga A I; Smith R A; Ponting C P; Dobson C M
Thermal stability of the three domains of streptokinase studied by circular dichroism and nuclear magnetic resonance.
Protein science : a publication of the Protein Society 1996;5(12):2583-91.
1996: Balbach J; Forge V; Lau W S; van Nuland N A; Brew K; Dobson C M
Protein folding monitored at individual residues during a two-dimensional NMR experiment.
Science (New York, N.Y.) 1996;274(5290):1161-3.
1996: Plaxco K W; Dobson C M
Time-resolved biophysical methods in the study of protein folding.
Current opinion in structural biology 1996;6(5):630-6.
1996: Plaxco K W; Spitzfaden C; Campbell I D; Dobson C M
Rapid refolding of a proline-rich all-beta-sheet fibronectin type III module.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(20):10703-6.
1996: Parrado J; Escuredo P R; Conejero-Lara F; Kotik M; Ponting C P; Asenjo J A; Dobson C M
Molecular characterisation of a thermoactive beta-1,3-glucanase from Oerskovia xanthineolytica.
Biochimica et biophysica acta 1996;1296(2):145-51.
1996: Bolin K A; Pitkeathly M; Miranker A; Smith L J; Dobson C M
Insight into a random coil conformation and an isolated helix: structural and dynamical characterisation of the C-helix peptide from hen lysozyme.
Journal of molecular biology 1996;261(3):443-53.
1996: Parrado J; Conejero-Lara F; Smith R A; Marshall J M; Ponting C P; Dobson C M
The domain organization of streptokinase: nuclear magnetic resonance, circular dichroism, and functional characterization of proteolytic fragments.
Protein science : a publication of the Protein Society 1996;5(4):693-704.
1996: Buck M; Schwalbe H; Dobson C M
Main-chain dynamics of a partially folded protein: 15N NMR relaxation measurements of hen egg white lysozyme denatured in trifluoroethanol.
Journal of molecular biology 1996;257(3):669-83.
1996: Miranker A D; Dobson C M
Collapse and cooperativity in protein folding.
Current opinion in structural biology 1996;6(1):31-42.
1996: Smith L J; Bolin K A; Schwalbe H; MacArthur M W; Thornton J M; Dobson C M
Analysis of main chain torsion angles in proteins: prediction of NMR coupling constants for native and random coil conformations.
Journal of molecular biology 1996;255(3):494-506.
1996: Miranker A; Robinson C V; Radford S E; Dobson C M
Investigation of protein folding by mass spectrometry.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(1):93-101.
1996: Yang J J; van den Berg B; Pitkeathly M; Smith L J; Bolin K A; Keiderling T A; Redfield C; Dobson C M; Radford S E
Native-like secondary structure in a peptide from the alpha-domain of hen lysozyme.
Folding & design 1996;1(6):473-84.
1996: Smith L J; Fiebig K M; Schwalbe H; Dobson C M
The concept of a random coil. Residual structure in peptides and denatured proteins.
Folding & design 1996;1(5):R95-106.
1995: Schulman B A; Redfield C; Peng Z Y; Dobson C M; Kim P S
Different subdomains are most protected from hydrogen exchange in the molten globule and native states of human alpha-lactalbumin.
Journal of molecular biology 1995;253(5):651-7.
1995: Morozova L A; Haynie D T; Arico-Muendel C; Van Dael H; Dobson C M
Structural basis of the stability of a lysozyme molten globule.
Nature structural biology 1995;2(10):871-5.
1995: Balbach J; Forge V; van Nuland N A; Winder S L; Hore P J; Dobson C M
Following protein folding in real time using NMR spectroscopy.
Nature structural biology 1995;2(10):865-70.
1995: Buck M; Schwalbe H; Dobson C M
Characterization of conformational preferences in a partly folded protein by heteronuclear NMR spectroscopy: assignment and secondary structure analysis of hen egg-white lysozyme in trifluoroethanol.
Biochemistry 1995;34(40):13219-32.
1995: Yang J J; Buck M; Pitkeathly M; Kotik M; Haynie D T; Dobson C M; Radford S E
Conformational properties of four peptides spanning the sequence of hen lysozyme.
Journal of molecular biology 1995;252(4):483-91.
1995: Smith L J; Mark A E; Dobson C M; van Gunsteren W F
Comparison of MD simulations and NMR experiments for hen lysozyme. Analysis of local fluctuations, cooperative motions, and global changes.
Biochemistry 1995;34(34):10918-31.
1995: Spraggon G; Phillips C; Nowak U K; Ponting C P; Saunders D; Dobson C M; Stuart D I; Jones E Y
The crystal structure of the catalytic domain of human urokinase-type plasminogen activator.
Structure (London, England : 1993) 1995;3(7):681-91.
1995: Pardon E; Haezebrouck P; De Baetselier A; Hooke S D; Fancourt K T; Desmet J; Dobson C M; Van Dael H; Joniau M
A Ca(2+)-binding chimera of human lysozyme and bovine alpha-lactalbumin that can form a molten globule.
The Journal of biological chemistry 1995;270(18):10514-24.
1995: Radford S E; Dobson C M
Insights into protein folding using physical techniques: studies of lysozyme and alpha-lactalbumin.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1995;348(1323):17-25.
1995: Buck M; Boyd J; Redfield C; MacKenzie D A; Jeenes D J; Archer D B; Dobson C M
Structural determinants of protein dynamics: analysis of 15N NMR relaxation measurements for main-chain and side-chain nuclei of hen egg white lysozyme.
Biochemistry 1995;34(12):4041-55.
1995: Haezebrouck P; Joniau M; Van Dael H; Hooke S D; Woodruff N D; Dobson C M
An equilibrium partially folded state of human lysozyme at low pH.
Journal of molecular biology 1995;246(3):382-7.
1995: Kotik M; Radford S E; Dobson C M
Comparison of the refolding of hen lysozyme from dimethyl sulfoxide and guanidinium chloride.
Biochemistry 1995;34(5):1714-24.
1994: Robinson C V; Gross M; Eyles S J; Ewbank J J; Mayhew M; Hartl F U; Dobson C M; Radford S E
Conformation of GroEL-bound alpha-lactalbumin probed by mass spectrometry.
Nature 1994;372(6507):646-51.
1994: Hadfield A T; Harvey D J; Archer D B; MacKenzie D A; Jeenes D J; Radford S E; Lowe G; Dobson C M; Johnson L N
Crystal structure of the mutant D52S hen egg white lysozyme with an oligosaccharide product.
Journal of molecular biology 1994;243(5):856-72.
1994: Taddei N; Buck M; Broadhurst R W; Stefani M; Ramponi G; Dobson C M
Equilibrium unfolding studies of horse muscle acylphosphatase.
European journal of biochemistry / FEBS 1994;225(3):811-7.
1994: Eyles S J; Radford S E; Robinson C V; Dobson C M
Kinetic consequences of the removal of a disulfide bridge on the folding of hen lysozyme.
Biochemistry 1994;33(44):13038-48.
1994: Smith L J; Alexandrescu A T; Pitkeathly M; Dobson C M
Solution structure of a peptide fragment of human alpha-lactalbumin in trifluoroethanol: a model for local structure in the molten globule.
Structure (London, England : 1993) 1994;2(8):703-12.
1994: Hooke S D; Radford S E; Dobson C M
The refolding of human lysozyme: a comparison with the structurally homologous hen lysozyme.
Biochemistry 1994;33(19):5867-76.
1994: Itzhaki L S; Evans P A; Dobson C M; Radford S E
Tertiary interactions in the folding pathway of hen lysozyme: kinetic studies using fluorescent probes.
Biochemistry 1994;33(17):5212-20.
1994: Smith L J; Redfield C; Smith R A; Dobson C M; Clore G M; Gronenborn A M; Walter M R; Naganbushan T L; Wlodawer A
Comparison of four independently determined structures of human recombinant interleukin-4.
Nature structural biology 1994;1(5):301-10.
1994: Redfield C; Smith L J; Boyd J; Lawrence G M; Edwards R G; Gershater C J; Smith R A; Dobson C M
Analysis of the solution structure of human interleukin-4 determined by heteronuclear three-dimensional nuclear magnetic resonance techniques.
Journal of molecular biology 1994;238(1):23-41.
1994: Buck M; Radford S E; Dobson C M
Amide hydrogen exchange in a highly denatured state. Hen egg-white lysozyme in urea.
Journal of molecular biology 1994;237(3):247-54.
1994: Nowak U K; Cooper A; Saunders D; Smith R A; Dobson C M
Unfolding studies of the protease domain of urokinase-type plasminogen activator: the existence of partly folded states and stable subdomains.
Biochemistry 1994;33(10):2951-60.
1994: Li X; Bokman A M; Llinás M; Smith R A; Dobson C M
Solution structure of the kringle domain from urokinase-type plasminogen activator.
Journal of molecular biology 1994;235(5):1548-59.
1994: Lumb K J; Cheetham J C; Dobson C M
1H nuclear magnetic resonance studies of hen lysozyme-N-acetylglucosamine oligosaccharide complexes in solution. Application of chemical shifts for the comparison of conformational changes in solution and in the crystal.
Journal of molecular biology 1994;235(3):1072-87.
1994: Alexandrescu A T; Ng Y L; Dobson C M
Characterization of a trifluoroethanol-induced partially folded state of alpha-lactalbumin.
Journal of molecular biology 1994;235(2):587-99.
1994: Dobson C M; Evans P A; Radford S E
Understanding how proteins fold: the lysozyme story so far.
Trends in biochemical sciences 1994;19(1):31-7.
1994: Redfield C; Smith R A; Dobson C M
Structural characterization of a highly-ordered 'molten globule' at low pH.
Nature structural biology 1994;1(1):23-9.
1993: Miranker A; Robinson C V; Radford S E; Aplin R T; Dobson C M
Detection of transient protein folding populations by mass spectrometry.
Science (New York, N.Y.) 1993;262(5135):896-900.
1993: Van Dael H; Haezebrouck P; Morozova L; Arico-Muendel C; Dobson C M
Partially folded states of equine lysozyme. Structural characterization and significance for protein folding.
Biochemistry 1993;32(44):11886-94.
1993: Teuten A J; Cooper A; Smith R A; Dobson C M
Binding of a substrate analogue can induce co-operative structure in the plasmin serine-proteinase domain.
The Biochemical journal 1993;293 ( Pt 2)():567-72.
1993: Teuten A J; Broadhurst R W; Smith R A; Dobson C M
Characterization of structural and folding properties of streptokinase by n.m.r. spectroscopy.
The Biochemical journal 1993;290 ( Pt 2)():313-9.
1993: Smith L J; Sutcliffe M J; Redfield C; Dobson C M
Structure of hen lysozyme in solution.
Journal of molecular biology 1993;229(4):930-44.
1993: Alexandrescu A T; Evans P A; Pitkeathly M; Baum J; Dobson C M
Structure and dynamics of the acid-denatured molten globule state of alpha-lactalbumin: a two-dimensional NMR study.
Biochemistry 1993;32(7):1707-18.
1993: Buck M; Radford S E; Dobson C M
A partially folded state of hen egg white lysozyme in trifluoroethanol: structural characterization and implications for protein folding.
Biochemistry 1993;32(2):669-78.
1993: Nowak U K; Li X; Teuten A J; Smith R A; Dobson C M
NMR studies of the dynamics of the multidomain protein urokinase-type plasminogen activator.
Biochemistry 1993;32(1):298-309.
1992: Alexandrescu A T; Broadhurst R W; Wormald C; Chyan C L; Baum J; Dobson C M
1H-NMR assignments and local environments of aromatic residues in bovine, human and guinea pig variants of alpha-lactalbumin.
European journal of biochemistry / FEBS 1992;210(3):699-709.
1992: Raleigh D P; Evans P A; Pitkeathly M; Dobson C M
A peptide model for proline isomerism in the unfolded state of staphylococcal nuclease.
Journal of molecular biology 1992;228(2):338-42.
1992: Redfield C; Boyd J; Smith L J; Smith R A; Dobson C M
Loop mobility in a four-helix-bundle protein: 15N NMR relaxation measurements on human interleukin-4.
Biochemistry 1992;31(43):10431-7.
1992: Radford S E; Buck M; Topping K D; Dobson C M; Evans P A
Hydrogen exchange in native and denatured states of hen egg-white lysozyme.
Proteins 1992;14(2):237-48.
1992: Li X; Smith R A; Dobson C M
Sequential 1H NMR assignments and secondary structure of the kringle domain from urokinase.
Biochemistry 1992;31(40):9562-71.
1992: Lumb K J; Dobson C M
1H nuclear magnetic resonance studies of the interaction of urea with hen lysozyme. Origins of the conformational change induced in hen lysozyme by N-acetylglucosamine oligosaccharides.
Journal of molecular biology 1992;227(1):9-14.
1992: Radford S E; Dobson C M; Evans P A
The folding of hen lysozyme involves partially structured intermediates and multiple pathways.
Nature 1992;358(6384):302-7.
1992: Cooper A; Eyles S J; Radford S E; Dobson C M
Thermodynamic consequences of the removal of a disulphide bridge from hen lysozyme.
Journal of molecular biology 1992;225(4):939-43.
1992: Smith L J; Redfield C; Boyd J; Lawrence G M; Edwards R G; Smith R A; Dobson C M
Human interleukin 4. The solution structure of a four-helix bundle protein.
Journal of molecular biology 1992;224(4):899-904.
1992: Li X A; Sutcliffe M J; Schwartz T W; Dobson C M
Sequence-specific 1H NMR assignments and solution structure of bovine pancreatic polypeptide.
Biochemistry 1992;31(4):1245-53.
1992: Lumb K J; Aplin R T; Radford S E; Archer D B; Jeenes D J; Lambert N; MacKenzie D A; Dobson C M; Lowe G
A study of D52S hen lysozyme-GlcNAc oligosaccharide complexes by NMR spectroscopy and electrospray mass spectrometry.
FEBS letters 1992;296(2):153-7.
1991: Redfield C; Smith L J; Boyd J; Lawrence G M; Edwards R G; Smith R A; Dobson C M
Secondary structure and topology of human interleukin 4 in solution.
Biochemistry 1991;30(46):11029-35.
1991: Cheetham J C; Raleigh D P; Griest R E; Redfield C; Dobson C M; Rees A R
Antigen mobility in the combining site of an anti-peptide antibody.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(18):7968-72.
1991: Oswald R E; Sutcliffe M J; Bamberger M; Loring R H; Braswell E; Dobson C M
Solution structure of neuronal bungarotoxin determined by two-dimensional NMR spectroscopy: sequence-specific assignments, secondary structure, and dimer formation.
Biochemistry 1991;30(20):4901-9.
1991: Miranker A; Radford S E; Karplus M; Dobson C M
Demonstration by NMR of folding domains in lysozyme.
Nature 1991;349(6310):633-6.
1991: Smith L J; Sutcliffe M J; Redfield C; Dobson C M
Analysis of phi and chi 1 torsion angles for hen lysozyme in solution from 1H NMR spin-spin coupling constants.
Biochemistry 1991;30(4):986-96.
1991: Radford S E; Woolfson D N; Martin S R; Lowe G; Dobson C M
A three-disulphide derivative of hen lysozyme. Structure, dynamics and stability.
The Biochemical journal 1991;273(Pt 1)():211-7.
1991: Broadhurst R W; Dobson C M; Hore P J; Radford S E; Rees M L
A photochemically induced dynamic nuclear polarization study of denatured states of lysozyme.
Biochemistry 1991;30(2):405-12.
1991: Teuten A J; Smith R A; Dobson C M
Domain interactions in human plasminogen studied by proton NMR.
FEBS letters 1991;278(1):17-22.
1991: Sutcliffe M J; Dobson C M
Relaxation data in NMR structure determination: model calculations for the lysozyme-Gd3+ complex.
Proteins 1991;10(2):117-29.
1991: Dobson C M
NMR spectroscopy and protein folding: studies of lysozyme and alpha-lactalbumin.
Ciba Foundation symposium 1991;161():167-81; discussion 181-9.
1991: Evans P A; Topping K D; Woolfson D N; Dobson C M
Hydrophobic clustering in nonnative states of a protein: interpretation of chemical shifts in NMR spectra of denatured states of lysozyme.
Proteins 1991;9(4):248-66.
1990: Redfield C; Dobson C M
1H NMR studies of human lysozyme: spectral assignment and comparison with hen lysozyme.
Biochemistry 1990;29(31):7201-14.
1990: Archer D B; Jeenes D J; MacKenzie D A; Brightwell G; Lambert N; Lowe G; Radford S E; Dobson C M
Hen egg white lysozyme expressed in, and secreted from, Aspergillus niger is correctly processed and folded.
Bio/technology (Nature Publishing Company) 1990;8(8):741-5.
1989: Bogusky M J; Dobson C M; Smith R A
Reversible independent unfolding of the domains of urokinase monitored by 1H NMR.
Biochemistry 1989;28(16):6728-35.
1989: Oswald R E; Bogusky M J; Bamberger M; Smith R A; Dobson C M
Dynamics of the multidomain fibrinolytic protein urokinase from two-dimensional NMR.
Nature 1989;337(6207):579-82.
1989: Baum J; Dobson C M; Evans P A; Hanley C
Characterization of a partly folded protein by NMR methods: studies on the molten globule state of guinea pig alpha-lactalbumin.
Biochemistry 1989;28(1):7-13.
1989: Evans P A; Kautz R A; Fox R O; Dobson C M
A magnetization-transfer nuclear magnetic resonance study of the folding of staphylococcal nuclease.
Biochemistry 1989;28(1):362-70.
1988: Redfield C; Dobson C M
Sequential 1H NMR assignments and secondary structure of hen egg white lysozyme in solution.
Biochemistry 1988;27(1):122-36.
1987: Dobson C M; Lian L Y
A 31P MAS NMR study of cytidine 2'-phosphate bound to ribonuclease A in the crystalline state.
FEBS letters 1987;225(1-2):183-7.
1987: Evans P A; Dobson C M; Kautz R A; Hatfull G; Fox R O
Proline isomerism in staphylococcal nuclease characterized by NMR and site-directed mutagenesis.
Nature 1987;329(6136):266-8.
1986: Post C B; Brooks B R; Karplus M; Dobson C M; Artymiuk P J; Cheetham J C; Phillips D C
Molecular dynamics simulations of native and substrate-bound lysozyme. A study of the average structures and atomic fluctuations.
Journal of molecular biology 1986;190(3):455-79.
1986: Fox R O; Evans P A; Dobson C M
Multiple conformations of a protein demonstrated by magnetization transfer NMR spectroscopy.
Nature 1986;320(6058):192-4.
1985: Redfield C; Dobson C M; Scheek R M; Stob S; Kaptein R
Surface accessibility of aromatic residues in human lysozyme using photochemically induced dynamic nuclear polarization NMR spectroscopy.
FEBS letters 1985;185(2):248-52.
1985: Fett J W; Strydom D J; Lobb R R; Alderman E M; Vallee B L; Artymiuk P J; Collett S; Phillips D C; Dobson C M; Redfield C
Lysozyme: a major secretory product of a human colon carcinoma cell line.
Biochemistry 1985;24(4):965-75.

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