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Christopher Dobson

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Physiology

Protein Folding

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Dorothea Pinotsi; Alexander K Buell; Christopher M Dobson; Gabriele S Kaminski Schierle; Clemens F Kaminski
A label-free, quantitative assay of amyloid fibril growth based on intrinsic fluorescence.
Fiona T S Chan; Christopher M Dobson; Gabriele S Kaminski Schierle; CARLOS WALTER BERTONCINI; Janet R Kumita; Clemens F Kaminski
Protein amyloids develop an intrinsic fluorescence signature during aggregation.
Anthony Fitzpatrick; Robert G Griffin; Christopher Jaroniec; Tuomas P J Knowles; Vladimir Ladizhansky; Cait E MacPhee; Helen R Mott; Shirley A Müller; Elena V Orlova; Helen R Saibil; Michele Vendruscolo; Luchun Wang; Christopher Waudby; Vikram S Bajaj; Marvin J Bayro; Marc A Caporini; Daniel K Clare; Alfonso De Simone; Galia T Debelouchina; Christopher M Dobson
Atomic structure and hierarchical assembly of a cross-β amyloid fibril.

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All Publications

2013: Dorothea Pinotsi; Alexander K Buell; Christopher M Dobson; Gabriele S Kaminski Schierle; Clemens F Kaminski
A label-free, quantitative assay of amyloid fibril growth based on intrinsic fluorescence.
Chembiochem : a European journal of chemical biology 2013;14(7):846-50.
2013: Fiona T S Chan; Christopher M Dobson; Gabriele S Kaminski Schierle; CARLOS WALTER BERTONCINI; Janet R Kumita; Clemens F Kaminski
Protein amyloids develop an intrinsic fluorescence signature during aggregation.
The Analyst 2013;138(7):2156-62.
2013: Anthony Fitzpatrick; Robert G Griffin; Christopher Jaroniec; Tuomas P J Knowles; Vladimir Ladizhansky; Cait E MacPhee; Helen R Mott; Shirley A Müller; Elena V Orlova; Helen R Saibil; Michele Vendruscolo; Luchun Wang; Christopher Waudby; Vikram S Bajaj; Marvin J Bayro; Marc A Caporini; Daniel K Clare; Alfonso De Simone; Galia T Debelouchina; Christopher M Dobson
Atomic structure and hierarchical assembly of a cross-β amyloid fibril.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(14):5468-73.
2013: Michele Vendruscolo; Christopher M Dobson
Structural biology: Protein self-assembly intermediates.
Nature chemical biology 2013;9(4):216-7.
2013: Alexander K Buell; Christopher M Dobson; Peter Hung; Xavier Salvatella; Mark E Welland; Tuomas P J Knowles
Electrostatic effects in filamentous protein aggregation.
Biophysical journal 2013;104(5):1116-26.
2013: Amy Ruth Wyatt; Patrick Constantinescu; Christopher M Dobson; Heath Ecroyd; Janet R Kumita; Mark R Wilson; Justin J Yerbury
Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms.
FEBS letters 2013;587(5):398-403.
2013: Priyanka Narayan; Seema Qamar; Peter St George-Hyslop; Laura Weimann; Mark R Wilson; John A Carver; Christopher M Dobson; Kristina A Ganzinger; James McColl; Sarah Meehan; David Klenerman
Single molecule characterization of the interactions between amyloid-β peptides and the membranes of hippocampal cells.
Journal of the American Chemical Society 2013;135(4):1491-8.
2013: Prajwal Ciryam; Christopher M Dobson; Richard I Morimoto; Michele Vendruscolo; Edward P O'Brien
In vivo translation rates can substantially delay the cotranslational folding of the Escherichia coli cytosolic proteome.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(2):E132-40.
2012: Priyanka Narayan; Mark R Wilson; John A Carver; Christopher M Dobson; Sarah Meehan; David Klenerman
Amyloid-β oligomers are sequestered by both intracellular and extracellular chaperones.
Biochemistry 2012;51(46):9270-6.
2012: Cintia Roodveldt; Gian Gaetano Tartaglia; August Andersson; Alexander K Buell; Erwin J De Genst; Christopher M Dobson; Adahir Labrador-Garrido; Michele Vendruscolo
A rationally designed six-residue swap generates comparability in the aggregation behavior of α-synuclein and β-synuclein.
Biochemistry 2012;51(44):8771-8.
2012: Tuomas P J Knowles; Sarah Meehan; Luke Rajah; Andrew Baldwin; Alfonso De Simone; Christopher M Dobson; Anthony Fitzpatrick; Michele Vendruscolo; Mark E Welland; Eugene M Terentjev
Twisting transition between crystalline and fibrillar phases of aggregated peptides.
Physical review letters 2012;109(15):158101.
2012: Samuel I A Cohen; Christopher M Dobson; Michele Vendruscolo; Tuomas P J Knowles
From macroscopic measurements to microscopic mechanisms of protein aggregation.
Journal of molecular biology 2012;421(2-3):160-71.
2012: Benedetta Mannini; Sarah Meehan; Amanda Penco; Annalisa Relini; Cintia Roodveldt; Maria van Waarde-Verhagen; Mark R Wilson; Mariagioia Zampagni; Matilde Boninsegna; Silvia Campioni; Roberta Cascella; Cristina Cecchi; Christopher M Dobson; Harm H Kampinga; Fabrizio Chiti
Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(31):12479-84.
2012: Edward P O'Brien; Michele Vendruscolo; John Christodoulou; Christopher M Dobson
Trigger factor slows co-translational folding through kinetic trapping while sterically protecting the nascent chain from aberrant cytosolic interactions.
Journal of the American Chemical Society 2012;134(26):10920-32.
2012: Eva K McGuire; Michael Motskin; Jeremy N Skepper; Shane D Bergin; Benedetta Bolognesi; Christopher M Dobson; Tuomas P J Knowles; Leila M Luheshi; David W McComb; Alexandra E Porter
Selenium-enhanced electron microscopic imaging of different aggregate forms of a segment of the amyloid β peptide in cells.
ACS nano 2012;6(6):4740-7.
2012: Elena Speretta; Gian Gaetano Tartaglia; Teresa P Barros; Damian C Crowther; Giorgio Favrin; Sara Imarisio; Thomas R Jahn; David A Lomas; Leila M Luheshi; Christopher M Dobson
Expression in drosophila of tandem amyloid β peptides provides insights into links between aggregation and neurotoxicity.
The Journal of biological chemistry 2012;287(24):20748-54.
2012: Francesco Bemporad; Fabrizio Chiti; Alfonso De Simone; Christopher M Dobson
Characterizing intermolecular interactions that initiate native-like protein aggregation.
Biophysical journal 2012;102(11):2595-604.
2012: Nunilo Cremades; Emma Deas; Christopher M Dobson; Paul Dunne; Andrey Y Abramov; Francesco A Aprile; CARLOS WALTER BERTONCINI; Allen Y Chen; Richard W Clarke; Samuel I A Cohen; Tuomas P J Knowles; Angel Orte; Massimo Sandal; Nicholas W Wood; David Klenerman
Direct observation of the interconversion of normal and toxic forms of α-synuclein.
Cell 2012;149(5):1048-59.
2012: Alexander K Buell; Anne Dhulesia; Christopher M Dobson; Tuomas P J Knowles; Duncan A White; Mark E Welland
Detailed analysis of the energy barriers for amyloid fibril growth.
Angewandte Chemie (International ed. in English) 2012;51(21):5247-51.
2012: Elisa Evangelisti; Caterina Sgromo; Matteo Becatti; Roberta Cascella; Cristina Cecchi; Fabrizio Chiti; Christopher M Dobson; Massimo Stefani
Membrane lipid composition and its physicochemical properties define cell vulnerability to aberrant protein oligomers.
Journal of cell science 2012;125(Pt 10):2416-27.
2012: Giuliana Fusco; Shang-Te Danny Hsu; Michele Vendruscolo; Francesco Bemporad; Fabrizio Chiti; Alfonso De Simone; Christopher M Dobson
¹H, ¹³C and ¹⁵N resonance assignments of human muscle acylphosphatase.
Biomolecular NMR assignments 2012;6(1):27-9.
2012: Minkoo Ahn; Erwin De Genst; Christopher M Dobson; Miklos Erdelyi; Gabriele S Kaminski Schierle; Clemens F Kaminski; Janet R Kumita
Analysis of the native structure, stability and aggregation of biotinylated human lysozyme.
PloS one 2012;7(11):e50192.
2012: Erwin De Genst; Christopher M Dobson
Nanobodies as structural probes of protein misfolding and fibril formation.
Methods in molecular biology (Clifton, N.J.) 2012;911():533-58.
2012: Edward P O'Brien; Michele Vendruscolo; Christopher M Dobson
Prediction of variable translation rate effects on cotranslational protein folding.
Nature communications 2012;3():868.
2012: Alexander K Buell; Christopher M Dobson; Mark E Welland
Measuring the kinetics of amyloid fibril elongation using quartz crystal microbalances.
Methods in molecular biology (Clifton, N.J.) 2012;849():101-19.
2012: Jenna M Gregory; Teresa P Barros; Christopher M Dobson; Sarah Meehan; Leila M Luheshi
The aggregation and neurotoxicity of TDP-43 and its ALS-associated 25 kDa fragment are differentially affected by molecular chaperones in Drosophila.
PloS one 2012;7(2):e31899.
2011: Alexander K Buell; Christopher M Dobson; Elin K Esbjörner; Patrick J Riss; Gergely Toth; Mark E Welland; Duncan A White; Franklin I Aigbirhio; Tuomas P J Knowles
Probing small molecule binding to amyloid fibrils.
Physical chemistry chemical physics : PCCP 2011;13(45):20044-52.
2011: Michele Vendruscolo; Tuomas P J Knowles; Christopher M Dobson
Protein solubility and protein homeostasis: a generic view of protein misfolding disorders.
Cold Spring Harbor perspectives in biology 2011;3(12):.
2011: Amy Ruth Wyatt; Justin J Yerbury; Paula Berghofer; Christopher M Dobson; Ivan Greguric; Andrew Katsifis; Mark R Wilson
Clusterin facilitates in vivo clearance of extracellular misfolded proteins.
Cellular and molecular life sciences : CMLS 2011;68(23):3919-31.
2011: Sarah L Shammas; Shuyu Wang; Christopher Waudby; Mark E Welland; Alexander K Buell; John A Carver; Christopher M Dobson; Heath Ecroyd; Tuomas P J Knowles; Sarah Meehan
Binding of the molecular chaperone αB-crystallin to Aβ amyloid fibrils inhibits fibril elongation.
Biophysical journal 2011;101(7):1681-9.
2011: Anthony Fitzpatrick; Tuomas P J Knowles; Michele Vendruscolo; Christopher Waudby; Christopher M Dobson
Inversion of the balance between hydrophobic and hydrogen bonding interactions in protein folding and aggregation.
PLoS computational biology 2011;7(10):e1002169.
2011: Andrew Baldwin; Paul D Barker; John Christodoulou; Glyn L Devlin; Spencer J Anthony-Cahill; Anthony Fitzpatrick; Sally L Gras; Tuomas P J Knowles; Sarah Meehan; Maria F Mossuto; Sarah Lucy Shammas; Gian Gaetano Tartaglia; Michele Vendruscolo; Christopher Waudby; Christopher M Dobson
Metastability of native proteins and the phenomenon of amyloid formation.
Journal of the American Chemical Society 2011;133(36):14160-3.
2011: Marvin J Bayro; Neil R Birkett; Galia T Debelouchina; Christopher M Dobson; Matthew T Eddy; Werner E Maas; Cait E MacPhee; Melanie Rosay; Robert G Griffin
Intermolecular structure determination of amyloid fibrils with magic-angle spinning and dynamic nuclear polarization NMR.
Journal of the American Chemical Society 2011;133(35):13967-74.
2011: Gabriele S Kaminski Schierle; CARLOS WALTER BERTONCINI; Christopher M Dobson; Miklos Erdelyi; Elin K Esbjörner; Teresa Klein; Eric Rees; Markus Sauer; Sebastian van de Linde; Clemens F Kaminski
In situ measurements of the formation and morphology of intracellular β-amyloid fibrils by super-resolution fluorescence imaging.
Journal of the American Chemical Society 2011;133(33):12902-5.
2011: Samuel I A Cohen; Christopher M Dobson; Michele Vendruscolo; Tuomas P J Knowles
Nucleated polymerization with secondary pathways. III. Equilibrium behavior and oligomer populations.
The Journal of chemical physics 2011;135(6):065107.
2011: Samuel I A Cohen; Christopher M Dobson; Michele Vendruscolo; Tuomas P J Knowles
Nucleated polymerization with secondary pathways. II. Determination of self-consistent solutions to growth processes described by non-linear master equations.
The Journal of chemical physics 2011;135(6):065106.
2011: Samuel I A Cohen; Christopher M Dobson; Eugene M Terentjev; Michele Vendruscolo; Mark E Welland; Tuomas P J Knowles
Nucleated polymerization with secondary pathways. I. Time evolution of the principal moments.
The Journal of chemical physics 2011;135(6):065105.
2011: Maria F Mossuto; Gian G Tartaglia; Federico Agostini; Benedetta Bolognesi; Anne Dhulesia; Christopher M Dobson; Mireille Dumoulin; Bernat Guixer; Janet R Kumita; Xavier Salvatella
Disulfide bonds reduce the toxicity of the amyloid fibrils formed by an extracellular protein.
Angewandte Chemie (International ed. in English) 2011;50(31):7048-51.
2011: Kai J Kohlhoff; David A Lomas; Damian C Crowther; Christopher M Dobson; Thomas R Jahn; Michele Vendruscolo
The iFly tracking system for an automated locomotor and behavioural analysis of Drosophila melanogaster.
Integrative biology : quantitative biosciences from nano to macro 2011;3(7):755-60.
2011: Sarah L Shammas; Tuomas P J Knowles; Andrew Baldwin; Cait E MacPhee; Mark E Welland; Christopher M Dobson; Glyn L Devlin
Perturbation of the stability of amyloid fibrils through alteration of electrostatic interactions.
Biophysical journal 2011;100(11):2783-91.
2011: Alexander K Buell; Anne Dhulesia; Maria F Mossuto; Nunilo Cremades; Janet R Kumita; Mireille Dumoulin; Mark E Welland; Tuomas P J Knowles; Xavier Salvatella; Christopher M Dobson
Population of nonnative states of lysozyme variants drives amyloid fibril formation.
Journal of the American Chemical Society 2011;133(20):7737-43.
2011: Thomas R Jahn; Kai J Kohlhoff; Michael Scott; Gian Gaetano Tartaglia; David A Lomas; Christopher M Dobson; Michele Vendruscolo; Damian C Crowther
Detection of early locomotor abnormalities in a Drosophila model of Alzheimer's disease.
Journal of neuroscience methods 2011;197(1):186-9.
2011: Gabriele S Kaminski Schierle; CARLOS WALTER BERTONCINI; Fiona T S Chan; Annemieke T van der Goot; Stefanie Schwedler; Jeremy Skepper; Simon Schlachter; Tjakko van Ham; Alessandro Esposito; Janet R Kumita; Ellen A A Nollen; Christopher M Dobson; Clemens F Kaminski
A FRET sensor for non-invasive imaging of amyloid formation in vivo.
Chemphyschem : a European journal of chemical physics and physical chemistry 2011;12(3):673-80.
2011: Michele Vendruscolo; Christopher M Dobson
Protein dynamics: Moore's law in molecular biology.
Current biology : CB 2011;21(2):R68-70.
2011: Samuel I A Cohen; Christopher M Dobson; Michele Vendruscolo; Tuomas P J Knowles
Nucleated polymerisation in the presence of pre-formed seed filaments.
International journal of molecular sciences 2011;12(9):5844-52.
2011: Graham Whyteside; Marcos J C Alcocer; Christopher M Dobson; Janet R Kumita; Maria Lazarou; Richard J Pleass; David B Archer
Native-state stability determines the extent of degradation relative to secretion of protein variants from Pichia pastoris.
PloS one 2011;6(7):e22692.
2011: Tuomas P J Knowles; Glyn L Devlin; Christopher M Dobson; Mark E Welland
Probing protein aggregation with quartz crystal microbalances.
Methods in molecular biology (Clifton, N.J.) 2011;752():137-45.
2010: Alexander K Buell; Christopher M Dobson; Tuomas P J Knowles; Mark E Welland
Interactions between amyloidophilic dyes and their relevance to studies of amyloid inhibitors.
Biophysical journal 2010;99(10):3492-7.
2010: Anne Dhulesia; Nunilo Cremades; Janet R Kumita; Shang-Te Danny Hsu; Maria F Mossuto; Mireille Dumoulin; Daniel Nietlispach; Mikael Akke; Xavier Salvatella; Christopher M Dobson
Local cooperativity in an amyloidogenic state of human lysozyme observed at atomic resolution.
Journal of the American Chemical Society 2010;132(44):15580-8.
2010: Marc A Caporini; Vikram S Bajaj; Mikhail Veshtort; Anthony Fitzpatrick; Cait E MacPhee; Michele Vendruscolo; Christopher M Dobson; Robert G Griffin
Accurate determination of interstrand distances and alignment in amyloid fibrils by magic angle spinning NMR.
The journal of physical chemistry. B 2010;114(42):13555-61.
2010: Maria F Mossuto; Anne Dhulesia; Glyn Devlin; Erica Frare; Janet R Kumita; Patrizia Polverino de Laureto; Mireille Dumoulin; Angelo Fontana; Christopher M Dobson; Xavier Salvatella
The non-core regions of human lysozyme amyloid fibrils influence cytotoxicity.
Journal of molecular biology 2010;402(5):783-96.
2010: Erwin J De Genst; Tim Guilliams; Joke Wellens; Elizabeth M O'Day; Christopher Waudby; Sarah Meehan; Mireille Dumoulin; Shang-Te Danny Hsu; Nunilo Cremades; Koen H G Verschueren; Els Pardon; Lode Wyns; Jan Steyaert; John Christodoulou; Christopher M Dobson
Structure and properties of a complex of α-synuclein and a single-domain camelid antibody.
Journal of molecular biology 2010;402(2):326-43.
2010: Marvin J Bayro; Thorsten Maly; Neil R Birkett; Cait E MacPhee; Christopher M Dobson; Robert G Griffin
High-resolution MAS NMR analysis of PI3-SH3 amyloid fibrils: backbone conformation and implications for protofilament assembly and structure .
Biochemistry 2010;49(35):7474-84.
2010: Alexander K Buell; Duncan A White; Christoph Meier; Mark E Welland; Tuomas P J Knowles; Christopher M Dobson
Surface attachment of protein fibrils via covalent modification strategies.
The journal of physical chemistry. B 2010;114(34):10925-38.
2010: Anders Sandberg; Leila M Luheshi; Sofia Söllvander; Teresa Pereira de Barros; Bertil Macao; Tuomas P J Knowles; Henrik Biverstål; Christofer Lendel; Frida Ekholm-Petterson; Anatoly Dubnovitsky; Lars Lannfelt; Christopher M Dobson; Torleif Härd
Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(35):15595-600.
2010: Benedetta Bolognesi; Janet R Kumita; Teresa P Barros; Elin K Esbjorner; Leila M Luheshi; Damian C Crowther; Mark R Wilson; Christopher M Dobson; Giorgio Favrin; Justin J Yerbury
ANS binding reveals common features of cytotoxic amyloid species.
ACS chemical biology 2010;5(8):735-40.
2010: Gian Gaetano Tartaglia; Christopher M Dobson; F Ulrich Hartl; Michele Vendruscolo
Physicochemical determinants of chaperone requirements.
Journal of molecular biology 2010;400(3):579-88.
2010: Christine L Hagan; Russell J K Johnson; Anne Dhulesia; Mireille Dumoulin; Janice Dumont; Erwin De Genst; John Christodoulou; Carol V Robinson; Christopher M Dobson; Janet R Kumita
A non-natural variant of human lysozyme (I59T) mimics the in vitro behaviour of the I56T variant that is responsible for a form of familial amyloidosis.
Protein engineering, design & selection : PEDS 2010;23(7):499-506.
2010: Alexander K Buell; Jamie R Blundell; Christopher M Dobson; Mark E Welland; Eugene M Terentjev; Tuomas P J Knowles
Frequency factors in a landscape model of filamentous protein aggregation.
Physical review letters 2010;104(22):228101.
2010: Duncan A White; Alexander K Buell; Tuomas P J Knowles; Mark E Welland; Christopher M Dobson
Protein aggregation in crowded environments.
Journal of the American Chemical Society 2010;132(14):5170-5.
2010: Christopher Waudby; Tuomas P J Knowles; Glyn L Devlin; Jeremy N Skepper; Heath Ecroyd; John A Carver; Mark E Welland; John Christodoulou; Christopher M Dobson; Sarah Meehan
The interaction of alphaB-crystallin with mature alpha-synuclein amyloid fibrils inhibits their elongation.
Biophysical journal 2010;98(5):843-51.
2010: Leila M Luheshi; Wolfgang Hoyer; Teresa Pereira de Barros; Iris Van Dijk-Härd; Ann-Christin Brorsson; Bertil Macao; Cecilia Persson; Damian C Crowther; David A Lomas; Stefan Ståhl; Christopher M Dobson; Torleif Härd
Sequestration of the Abeta peptide prevents toxicity and promotes degradation in vivo.
PLoS biology 2010;8(3):e1000334.
2010: Christofer Lendel; Benedetta Bolognesi; Anna Wahlström; Christopher M Dobson; Astrid Gräslund
Detergent-like interaction of Congo red with the amyloid beta peptide.
Biochemistry 2010;49(7):1358-60.
2010: Shang-Te Danny Hsu; Georg Blaser; Caroline Behrens; Lisa D Cabrita; Christopher M Dobson; Sophie E Jackson
Folding study of Venus reveals a strong ion dependence of its yellow fluorescence under mildly acidic conditions.
The Journal of biological chemistry 2010;285(7):4859-69.
2010: Christina R Bodner; Alexander S Maltsev; Christopher M Dobson; Ad Bax
Differential phospholipid binding of alpha-synuclein variants implicated in Parkinson's disease revealed by solution NMR spectroscopy.
Biochemistry 2010;49(5):862-71.
2010: Lisa D Cabrita; Christopher M Dobson; John Christodoulou
Protein folding on the ribosome.
Current opinion in structural biology 2010;20(1):33-45.
2010: Silvia Campioni; Benedetta Mannini; Mariagioia Zampagni; Anna Pensalfini; Claudia Parrini; Elisa Evangelisti; Annalisa Relini; Massimo Stefani; Christopher M Dobson; Cristina Cecchi; Fabrizio Chiti
A causative link between the structure of aberrant protein oligomers and their toxicity.
Nature chemical biology 2010;6(2):140-7.
2010: Tjakko J van Ham; Alessandro Esposito; Janet R Kumita; Shang-Te D Hsu; Gabriele S Kaminski Schierle; Clemens F Kaminski; Christopher M Dobson; Ellen A A Nollen; CARLOS WALTER BERTONCINI
Towards multiparametric fluorescent imaging of amyloid formation: studies of a YFP model of alpha-synuclein aggregation.
Journal of molecular biology 2010;395(3):627-42.
2010: Cintia Roodveldt; Adahir Labrador-Garrido; Elena Gonzalez-Rey; Rafael Fernandez-Montesinos; Marta Caro; Christian C Lachaud; Christopher Waudby; Mario Delgado; Christopher M Dobson; David Pozo Perez
Glial innate immunity generated by non-aggregated alpha-synuclein in mouse: differences between wild-type and Parkinson's disease-linked mutants.
PloS one 2010;5(10):e13481.
2009: Jane R Allison; Péter Várnai; Christopher M Dobson; Michele Vendruscolo
Determination of the free energy landscape of alpha-synuclein using spin label nuclear magnetic resonance measurements.
Journal of the American Chemical Society 2009;131(51):18314-26.
2009: Lisa D Cabrita; Shang-Te Danny Hsu; Helene Launay; Christopher M Dobson; John Christodoulou
Probing ribosome-nascent chain complexes produced in vivo by NMR spectroscopy.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(52):22239-44.
2009: Tuomas P J Knowles; Christopher Waudby; Glyn L Devlin; Samuel I A Cohen; Adriano Aguzzi; Michele Vendruscolo; Eugene M Terentjev; Mark E Welland; Christopher M Dobson
An analytical solution to the kinetics of breakable filament assembly.
Science (New York, N.Y.) 2009;326(5959):1533-7.
2009: Cintia Roodveldt; CARLOS WALTER BERTONCINI; August Andersson; Annemieke T van der Goot; Shang-Te Danny Hsu; Rafael Fernández-Montesinos; Jannie de Jong; Tjakko J van Ham; Ellen A A Nollen; David Pozo Perez; John Christodoulou; Christopher M Dobson
Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/alpha-synuclein complex by Hip.
The EMBO journal 2009;28(23):3758-70.
2009: Anneleen Vuchelen; Elizabeth O'Day; Erwin De Genst; Els Pardon; Lode Wyns; Mireille Dumoulin; Christopher M Dobson; John Christodoulou; Shang-Te Danny Hsu
(1)H, (13)C and (15)N assignments of a camelid nanobody directed against human alpha-synuclein.
Biomolecular NMR assignments 2009;3(2):231-3.
2009: Jennifer M Bui; Joerg Gsponer; Michele Vendruscolo; Christopher M Dobson
Analysis of sub-tauc and supra-tauc motions in protein Gbeta1 using molecular dynamics simulations.
Biophysical journal 2009;97(9):2513-20.
2009: Christofer Lendel; CARLOS WALTER BERTONCINI; Nunilo Cremades; Christopher Waudby; Michele Vendruscolo; Christopher M Dobson; Dale Schenk; John Christodoulou; Gergely Toth
On the mechanism of nonspecific inhibitors of protein aggregation: dissecting the interactions of alpha-synuclein with Congo red and lacmoid.
Biochemistry 2009;48(35):8322-34.
2009: Leila M Luheshi; Christopher M Dobson
Bridging the gap: from protein misfolding to protein misfolding diseases.
FEBS letters 2009;583(16):2581-6.
2009: Duncan A White; Alexander K Buell; Christopher M Dobson; Mark E Welland; Tuomas P J Knowles
Biosensor-based label-free assays of amyloid growth.
FEBS letters 2009;583(16):2587-92.
2009: Christina R Bodner; Christopher M Dobson; Adriaan Bax
Multiple tight phospholipid-binding modes of alpha-synuclein revealed by solution NMR spectroscopy.
Journal of molecular biology 2009;390(4):775-90.
2009: Shang-Te Danny Hsu; Lisa D Cabrita; Paola Fucini; John Christodoulou; Christopher M Dobson
Probing side-chain dynamics of a ribosome-bound nascent chain using methyl NMR spectroscopy.
Journal of the American Chemical Society 2009;131(24):8366-7.
2009: Paul Robustelli; Andrea Cavalli; Christopher M Dobson; Michele Vendruscolo; Xavier Salvatella
Folding of small proteins by Monte Carlo simulations with chemical shift restraints without the use of molecular fragment replacement or structural homology.
The journal of physical chemistry. B 2009;113(22):7890-6.
2009: Shang-Te Danny Hsu; CARLOS WALTER BERTONCINI; Christopher M Dobson
Use of protonless NMR spectroscopy to alleviate the loss of information resulting from exchange-broadening.
Journal of the American Chemical Society 2009;131(21):7222-3.
2009: Shang-Te Danny Hsu; Caroline Behrens; Lisa D Cabrita; Christopher M Dobson
1H, 15N and 13C assignments of yellow fluorescent protein (YFP) Venus.
Biomolecular NMR assignments 2009;3(1):67-72.
2009: Shang-Te Danny Hsu; Lisa D Cabrita; John Christodoulou; Christopher M Dobson
1H, 15N and 13C assignments of domain 5 of Dictyostelium discoideum gelation factor (ABP-120) in its native and 8M urea-denatured states.
Biomolecular NMR assignments 2009;3(1):29-31.
2009: Shang-Te Danny Hsu; Christopher M Dobson
1H, 15N and 13C assignments of the dimeric ribosome binding domain of trigger factor from Escherichia coli.
Biomolecular NMR assignments 2009;3(1):17-20.
2009: Alexander K Buell; Gian Gaetano Tartaglia; Neil R Birkett; Christopher Waudby; Michele Vendruscolo; Xavier Salvatella; Mark E Welland; Christopher M Dobson; Tuomas P J Knowles
Position-dependent electrostatic protection against protein aggregation.
Chembiochem : a European journal of chemical biology 2009;10(8):1309-12.
2009: Shang-Te Danny Hsu; Lisa D Cabrita; Paola Fucini; Christopher M Dobson; John Christodoulou
Structure, dynamics and folding of an immunoglobulin domain of the gelation factor (ABP-120) from Dictyostelium discoideum.
Journal of molecular biology 2009;388(4):865-79.
2009: Natàlia Carulla; Min Zhou; Muriel Arimon; Margarida Gairí; Ernest Giralt; Carol V Robinson; Christopher M Dobson
Experimental characterization of disordered and ordered aggregates populated during the process of amyloid fibril formation.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(19):7828-33.
2009: Gian Gaetano Tartaglia; Sebastian Pechmann; Christopher M Dobson; Michele Vendruscolo
A relationship between mRNA expression levels and protein solubility in E. coli.
Journal of molecular biology 2009;388(2):381-9.
2009: Martino Calamai; Gian Gaetano Tartaglia; Michele Vendruscolo; Fabrizio Chiti; Christopher M Dobson
Mutational analysis of the aggregation-prone and disaggregation-prone regions of acylphosphatase.
Journal of molecular biology 2009;387(4):965-74.
2009: Erica Frare; Maria F Mossuto; Patrizia Polverino de Laureto; Serena Tolin; Linda Menzer; Mireille Dumoulin; Christopher M Dobson; Angelo Fontana
Characterization of oligomeric species on the aggregation pathway of human lysozyme.
Journal of molecular biology 2009;387(1):17-27.
2009: Justin J Yerbury; Janet R Kumita; Sarah Meehan; Christopher M Dobson; Mark R Wilson
alpha2-Macroglobulin and haptoglobin suppress amyloid formation by interacting with prefibrillar protein species.
The Journal of biological chemistry 2009;284(7):4246-54.
2009: Michele Vendruscolo; Christopher M Dobson
Quantitative approaches to defining normal and aberrant protein homeostasis.
Faraday discussions 2009;143():277-91; discussion 359-72.
2009: Stephen Poon; N R Birkett; Susan B Fowler; B F Luisi; Christopher M Dobson; Jesús Zurdo
Amyloidogenicity and aggregate cytotoxicity of human glucagon-like peptide-1 (hGLP-1).
Protein and peptide letters 2009;16(12):1548-56.
2009: Marvin J Bayro; Thorsten Maly; Neil R Birkett; Christopher M Dobson; Robert G Griffin
Long-range correlations between aliphatic 13C nuclei in protein MAS NMR spectroscopy.
Angewandte Chemie (International ed. in English) 2009;48(31):5708-10.
2009: Kiran Yanamandra; Oleg A Alexeyev; Vladimir Zamotin; Vaibhav Srivastava; Andrei Shchukarev; Ann-Christin Brorsson; Gian Gaetano Tartaglia; Thomas Vogl; Rakez Kayed; Gunnar Wingsle; Jan Olsson; Christopher M Dobson; Anders Bergh; Fredrik Elgh; Ludmilla A Morozova-Roche
Amyloid formation by the pro-inflammatory S100A8/A9 proteins in the ageing prostate.
PloS one 2009;4(5):e5562.
2008: Pak-Ho Chan; Els Pardon; Linda Menzer; Erwin De Genst; Janet R Kumita; John Christodoulou; Dirk Saerens; Alain Brans; Fabrice Bouillenne; David B Archer; Carol V Robinson; Serge Muyldermans; Alain Matagne; Christina Redfield; Lode Wyns; Christopher M Dobson; Mireille Dumoulin
Engineering a camelid antibody fragment that binds to the active site of human lysozyme and inhibits its conversion into amyloid fibrils.
Biochemistry 2008;47(42):11041-54.
2008: Giulia Calloni; Christofer Lendel; Silvia Campioni; Silva Giannini; Alessandra Gliozzi; Annalisa Relini; Michele Vendruscolo; Christopher M Dobson; Xavier Salvatella; Fabrizio Chiti
Structure and dynamics of a partially folded protein are decoupled from its mechanism of aggregation.
Journal of the American Chemical Society 2008;130(39):13040-50.
2008: Cintia Roodveldt; John Christodoulou; Christopher M Dobson
Immunological features of alpha-synuclein in Parkinson's disease.
Journal of cellular and molecular medicine 2008;12(5B):1820-9.
2008: Tuomas P J Knowles; Hans Peter Lang; Wenmiao Shu; Christopher M Dobson; Christoph Gerber; François Huber; Mark E Welland
Label-free detection of amyloid growth with microcantilever sensors.
Nanotechnology 2008;19(38):384007.
2008: Angel Orte; Neil R Birkett; Richard W Clarke; Glyn L Devlin; Christopher M Dobson; David Klenerman
Direct characterization of amyloidogenic oligomers by single-molecule fluorescence.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(38):14424-9.
2008: Gian Gaetano Tartaglia; Amol P Pawar; Silvia Campioni; Christopher M Dobson; Fabrizio Chiti; Michele Vendruscolo
Prediction of aggregation-prone regions in structured proteins.
Journal of molecular biology 2008;380(2):425-36.
2008: Jörg Gsponer; John Christodoulou; Andrea Cavalli; Jennifer M Bui; Barbara Richter; Christopher M Dobson; Michele Vendruscolo
A coupled equilibrium shift mechanism in calmodulin-mediated signal transduction.
Structure (London, England : 1993) 2008;16(5):736-46.
2008: Robert C Rivers; Janet R Kumita; Gian Gaetano Tartaglia; Matthew M. Dedmon; Amol P Pawar; Michele Vendruscolo; Christopher M Dobson; John Christodoulou
Molecular determinants of the aggregation behavior of alpha- and beta-synuclein.
Protein science : a publication of the Protein Society 2008;17(5):887-98.
2008: Sally L Gras; Anna K Tickler; Adam M Squires; Glyn L Devlin; Michael A Horton; Christopher M Dobson; Cait E MacPhee
Functionalised amyloid fibrils for roles in cell adhesion.
Biomaterials 2008;29(11):1553-62.
2008: Péter Várnai; Christopher M Dobson; Michele Vendruscolo
Determination of the transition state ensemble for the folding of ubiquitin from a combination of Phi and Psi analyses.
Journal of molecular biology 2008;377(2):575-88.
2008: Nico A J van Nuland; Christopher M Dobson; Lynne Regan
Characterization of folding the four-helix bundle protein Rop by real-time NMR.
Protein engineering, design & selection : PEDS 2008;21(3):165-70.
2008: Leila M Luheshi; Damian C Crowther; Christopher M Dobson
Protein misfolding and disease: from the test tube to the organism.
Current opinion in chemical biology 2008;12(1):25-31.
2008: Mookyung Cheon; Giorgio Favrin; Iksoo Chang; Christopher M Dobson; Michele Vendruscolo
Calculation of the free energy barriers in the oligomerisation of Abeta peptide fragments.
Frontiers in bioscience : a journal and virtual library 2008;13():5614-22.
2008: Andrew Baldwin; Spencer J Anthony-Cahill; Tuomas P J Knowles; Guy Lippens; John Christodoulou; Paul D Barker; Christopher M Dobson
Measurement of amyloid fibril length distributions by inclusion of rotational motion in solution NMR diffusion measurements.
Angewandte Chemie (International ed. in English) 2008;47(18):3385-7.
2007: Tuomas P J Knowles; Anthony Fitzpatrick; Sarah Meehan; Helen R Mott; Michele Vendruscolo; Christopher M Dobson; Mark E Welland
Role of intermolecular forces in defining material properties of protein nanofibrils.
Science (New York, N.Y.) 2007;318(5858):1900-3.
2007: Leila M Luheshi; Gian Gaetano Tartaglia; Ann-Christin Brorsson; Amol P Pawar; Ian E Watson; Fabrizio Chiti; Michele Vendruscolo; David A Lomas; Christopher M Dobson; Damian C Crowther
Systematic in vivo analysis of the intrinsic determinants of amyloid Beta pathogenicity.
PLoS biology 2007;5(11):e290.
2007: Shang-Te Danny Hsu; Paola Fucini; Lisa D Cabrita; Hélène Launay; Christopher M Dobson; John Christodoulou
Structure and dynamics of a ribosome-bound nascent chain by NMR spectroscopy.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(42):16516-21.
2007: Andrew Baldwin; John Christodoulou; Paul D Barker; Christopher M Dobson; Guy Lippens
Contribution of rotational diffusion to pulsed field gradient diffusion measurements.
The Journal of chemical physics 2007;127(11):114505.
2007: Sarah Meehan; Tuomas P J Knowles; Andrew Baldwin; Jeffrey F Smith; Adam M Squires; Phillip Clements; Teresa M Treweek; Heath Ecroyd; Gian Gaetano Tartaglia; Michele Vendruscolo; Cait E MacPhee; Christopher M Dobson; John A Carver
Characterisation of amyloid fibril formation by small heat-shock chaperone proteins human alphaA-, alphaB- and R120G alphaB-crystallins.
Journal of molecular biology 2007;372(2):470-84.
2007: Mookyung Cheon; Iksoo Chang; Sandipan Mohanty; Leila M Luheshi; Christopher M Dobson; Michele Vendruscolo; Giorgio Favrin
Structural reorganisation and potential toxicity of oligomeric species formed during the assembly of amyloid fibrils.
PLoS computational biology 2007;3(9):1727-38.
2007: Justin J Yerbury; Stephen Poon; Sarah Meehan; Brianna Thompson; Janet R Kumita; Christopher M Dobson; Mark R Wilson
The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(10):2312-22.
2007: Stefan Auer; Christopher M Dobson; Michele Vendruscolo
Characterization of the nucleation barriers for protein aggregation and amyloid formation.
HFSP journal 2007;1(2):137-46.
2007: Tuomas P J Knowles; Wenmiao Shu; Glyn L Devlin; Sarah Meehan; Stefan Auer; Christopher M Dobson; Mark E Welland
Kinetics and thermodynamics of amyloid formation from direct measurements of fluctuations in fibril mass.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(24):10016-21.
2007: Andrea Cavalli; Xavier Salvatella; Christopher M Dobson; Michele Vendruscolo
Protein structure determination from NMR chemical shifts.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(23):9615-20.
2007: Jessica Meinhardt; Gian Gaetano Tartaglia; Amol Pawar; Tony Christopeit; Peter Hortschansky; Volker Schroeckh; Christopher M Dobson; Michele Vendruscolo; Marcus Fändrich
Similarities in the thermodynamics and kinetics of aggregation of disease-related Abeta(1-40) peptides.
Protein science : a publication of the Protein Society 2007;16(6):1214-22.
2007: Janet R Kumita; Stephen Poon; Gemma L Caddy; Christine L Hagan; Mireille Dumoulin; Justin J Yerbury; Elise M Stewart; Carol V Robinson; Mark R Wilson; Christopher M Dobson
The extracellular chaperone clusterin potently inhibits human lysozyme amyloid formation by interacting with prefibrillar species.
Journal of molecular biology 2007;369(1):157-67.
2007: Gian Gaetano Tartaglia; Sebastian Pechmann; Christopher M Dobson; Michele Vendruscolo
Life on the edge: a link between gene expression levels and aggregation rates of human proteins.
Trends in biochemical sciences 2007;32(5):204-6.
2006: Sonia Di Gaetano; Fulvio Guglielmi; Angela Arciello; Palma Mangione; Maria Monti; Daniela Pagnozzi; Sara Raimondi; Sofia Giorgetti; Stefania Orrù; Claudio Canale; Piero Pucci; Christopher M Dobson; Vittorio Bellotti; Renata Piccoli
Recombinant amyloidogenic domain of ApoA-I: analysis of its fibrillogenic potential.
Biochemical and biophysical research communications 2006;351(1):223-8.
2006: Joerg Gsponer; Harri Hopearuoho; Andrea Cavalli; Christopher M Dobson; Michele Vendruscolo
Geometry, energetics, and dynamics of hydrogen bonds in proteins: structural information derived from NMR scalar couplings.
Journal of the American Chemical Society 2006;128(47):15127-35.
2006: Martino Calamai; Janet R Kumita; John Mifsud; Claudia Parrini; Matteo Ramazzotti; Giampietro Ramponi; Niccolò Taddei; Fabrizio Chiti; Christopher M Dobson
Nature and significance of the interactions between amyloid fibrils and biological polyelectrolytes.
Biochemistry 2006;45(42):12806-15.
2006: Jeffrey F Smith; Tuomas P J Knowles; Christopher M Dobson; Cait E MacPhee; Mark E Welland
Characterization of the nanoscale properties of individual amyloid fibrils.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(43):15806-11.
2006: Michele Vendruscolo; Christopher M Dobson
Structural biology. Dynamic visions of enzymatic reactions.
Science (New York, N.Y.) 2006;313(5793):1586-7.
2006: Adam M Squires; Glyn L Devlin; Sally L Gras; Anna K Tickler; Cait E MacPhee; Christopher M Dobson
X-ray scattering study of the effect of hydration on the cross-beta structure of amyloid fibrils.
Journal of the American Chemical Society 2006;128(36):11738-9.
2006: Mireille Dumoulin; Janet R Kumita; Christopher M Dobson
Normal and aberrant biological self-assembly: Insights from studies of human lysozyme and its amyloidogenic variants.
Accounts of chemical research 2006;39(9):603-10.
2006: Erica Frare; Maria F Mossuto; Patrizia Polverino De Laureto; Mireille Dumoulin; Christopher M Dobson; Angelo Fontana
Identification of the core structure of lysozyme amyloid fibrils by proteolysis.
Journal of molecular biology 2006;361(3):551-61.
2006: Silvana Baglioni; Fiorella Casamenti; monica bucciantini; Leila M Luheshi; Niccolò Taddei; Fabrizio Chiti; Christopher M Dobson; Massimo Stefani
Prefibrillar amyloid aggregates could be generic toxins in higher organisms.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(31):8160-7.
2006: Glyn L Devlin; Tuomas P J Knowles; Adam M Squires; Margaret McCammon; Sally L Gras; Melanie R Nilsson; Carol V Robinson; Christopher M Dobson; Cait E MacPhee
The component polypeptide chains of bovine insulin nucleate or inhibit aggregation of the parent protein in a conformation-dependent manner.
Journal of molecular biology 2006;360(2):497-509.
2006: Reto Bader; Markus A Seeliger; Sadie E Kelly; Leopold L Ilag; Filip Meersman; Alejandra Limones; Ben F Luisi; Christopher M Dobson; Laura S Itzhaki
Folding and fibril formation of the cell cycle protein Cks1.
The Journal of biological chemistry 2006;281(27):18816-24.
2006: Tuomas P J Knowles; Jeffrey F Smith; Aidan Craig; Christopher M Dobson; Mark E Welland
Spatial persistence of angular correlations in amyloid fibrils.
Physical review letters 2006;96(23):238301.
2006: Damien Hall; Christopher M Dobson
Expanding to fill the gap: a possible role for inert biopolymers in regulating the extent of the 'macromolecular crowding' effect.
FEBS letters 2006;580(11):2584-90.
2006: Vidya Chandran; Elliott J Stollar; Kresten Lindorff-Larsen; Jeffrey F Harper; Walter J Chazin; Christopher M Dobson; Ben F Luisi; John Christodoulou
Structure of the regulatory apparatus of a calcium-dependent protein kinase (CDPK): a novel mode of calmodulin-target recognition.
Journal of molecular biology 2006;357(2):400-10.
2006: Filip Meersman; Christopher M Dobson
Probing the pressure-temperature stability of amyloid fibrils provides new insights into their molecular properties.
Biochimica et biophysica acta 2006;1764(3):452-60.
2006: Andrew Baldwin; Reto Bader; John Christodoulou; Cait E MacPhee; Christopher M Dobson; Paul D Barker
Cytochrome display on amyloid fibrils.
Journal of the American Chemical Society 2006;128(7):2162-3.
2006: Reto Bader; Richard Bamford; Jesús Zurdo; Ben F Luisi; Christopher M Dobson
Probing the mechanism of amyloidogenesis through a tandem repeat of the PI3-SH3 domain suggests a generic model for protein aggregation and fibril formation.
Journal of molecular biology 2006;356(1):189-208.
2006: Janet R Kumita; Russell J K Johnson; Marcos J C Alcocer; Mireille Dumoulin; Fredrik Holmqvist; Margaret McCammon; Carol V Robinson; David B Archer; Christopher M Dobson
Impact of the native-state stability of human lysozyme variants on protein secretion by Pichia pastoris.
The FEBS journal 2006;273(4):711-20.
2006: Fabrizio Chiti; Christopher M Dobson
Protein misfolding, functional amyloid, and human disease.
Annual review of biochemistry 2006;75():333-66.
2006: Marcus Fändrich; Giorgia Zandomeneghi; Mark R H Krebs; Marlis Kittler; Katrin Buder; Angela Rossner; Stefan H Heinemann; Christopher M Dobson; Stephan Diekmann
Apomyoglobin reveals a random-nucleation mechanism in amyloid protofibril formation.
Acta histochemica 2006;108(3):215-9.
2006: Christopher M Dobson
Protein aggregation and its consequences for human disease.
Protein and peptide letters 2006;13(3):219-27.
2005: David C Thorn; Sarah Meehan; Margaret Sunde; Agata Rekas; Sally L Gras; Cait E MacPhee; Christopher M Dobson; Mark R Wilson; John A Carver
Amyloid fibril formation by bovine milk kappa-casein and its inhibition by the molecular chaperones alphaS- and beta-casein.
Biochemistry 2005;44(51):17027-36.
2005: Caroline F Wright; Sarah A Teichmann; Jane Clarke; Christopher M Dobson
The importance of sequence diversity in the aggregation and evolution of proteins.
Nature 2005;438(7069):878-81.
2005: Martino Calamai; Fabrizio Chiti; Christopher M Dobson
Amyloid fibril formation can proceed from different conformations of a partially unfolded protein.
Biophysical journal 2005;89(6):4201-10.
2005: Russell J K Johnson; John Christodoulou; Mireille Dumoulin; Gemma L Caddy; Marcos J C Alcocer; Gareth J Murtagh; Janet R Kumita; Göran Larsson; Carol V Robinson; David B Archer; Ben F Luisi; Christopher M Dobson
Rationalising lysozyme amyloidosis: insights from the structure and solution dynamics of T70N lysozyme.
Journal of molecular biology 2005;352(4):823-36.
2005: Emily Collins; Julia Wirmer; Kenichi Hirai; Hideki Tachibana; Shin-ichi Segawa; Christopher M Dobson; Harald Schwalbe
Characterisation of disulfide-bond dynamics in non-native states of lysozyme and its disulfide deletion mutants by NMR.
Chembiochem : a European journal of chemical biology 2005;6(9):1619-27.
2005: Xavier Salvatella; Christopher M Dobson; Alan Fersht; Michele Vendruscolo
Determination of the folding transition states of barnase by using PhiI-value-restrained simulations validated by double mutant PhiIJ-values.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(35):12389-94.
2005: Georgia Plakoutsi; Francesco Bemporad; Martino Calamai; Niccolò Taddei; Christopher M Dobson; Fabrizio Chiti
Evidence for a mechanism of amyloid formation involving molecular reorganisation within native-like precursor aggregates.
Journal of molecular biology 2005;351(4):910-22.
2005: Rachel Wain; Lorna J Smith; Christopher M Dobson
Oxidative refolding of amyloidogenic variants of human lysozyme.
Journal of molecular biology 2005;351(3):662-71.
2005: Damien Hall; Nami Hirota; Christopher M Dobson
A toy model for predicting the rate of amyloid formation from unfolded protein.
Journal of molecular biology 2005;351(1):195-205.
2005: Claudia Parrini; Niccolò Taddei; Matteo Ramazzotti; Donatella Degl'Innocenti; Giampietro Ramponi; Christopher M Dobson; Fabrizio Chiti
Glycine residues appear to be evolutionarily conserved for their ability to inhibit aggregation.
Structure (London, England : 1993) 2005;13(8):1143-51.
2005: Natàlia Carulla; Gemma L Caddy; Damien R Hall; Jesús Zurdo; Margarida Gairí; Miguel Feliz; Ernest Giralt; Carol V Robinson; Christopher M Dobson
Molecular recycling within amyloid fibrils.
Nature 2005;436(7050):554-8.
2005: Susan B Fowler; Stephen Poon; Roman Muff; Fabrizio Chiti; Christopher M Dobson; Jesús Zurdo
Rational design of aggregation-resistant bioactive peptides: reengineering human calcitonin.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(29):10105-10.
2005: Amol P Pawar; Kateri F Dubay; Jesús Zurdo; Fabrizio Chiti; Michele Vendruscolo; Christopher M Dobson
Prediction of "aggregation-prone" and "aggregation-susceptible" regions in proteins associated with neurodegenerative diseases.
Journal of molecular biology 2005;350(2):379-92.
2005: K Hun Mok; Toshio Nagashima; Iain J Day; Peter J Hore; Christopher M Dobson
Multiple subsets of side-chain packing in partially folded states of alpha-lactalbumins.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(25):8899-904.
2005: Michele Vendruscolo; Christopher M Dobson
A glimpse at the organization of the protein universe.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(16):5641-2.
2005: Sigridur Kristjansdottir; Kresten Lindorff-Larsen; Wolfgang Fieber; Christopher M Dobson; Michele Vendruscolo; Flemming M Poulsen
Formation of native and non-native interactions in ensembles of denatured ACBP molecules from paramagnetic relaxation enhancement studies.
Journal of molecular biology 2005;347(5):1053-62.
2005: Matthew M. Dedmon; John Christodoulou; Mark R Wilson; Christopher M Dobson
Heat shock protein 70 inhibits alpha-synuclein fibril formation via preferential binding to prefibrillar species.
The Journal of biological chemistry 2005;280(15):14733-40.
2005: Giordana Marcon; Georgia Plakoutsi; Claudio Canale; Annalisa Relini; Niccolò Taddei; Christopher M Dobson; Giampietro Ramponi; Fabrizio Chiti
Amyloid formation from HypF-N under conditions in which the protein is initially in its native state.
Journal of molecular biology 2005;347(2):323-35.
2005: Giulia Calloni; Sara Zoffoli; Massimo Stefani; Christopher M Dobson; Fabrizio Chiti
Investigating the effects of mutations on protein aggregation in the cell.
The Journal of biological chemistry 2005;280(11):10607-13.
2005: Mireille Dumoulin; Denis Canet; Alexander M Last; Els Pardon; David B Archer; Serge Muyldermans; Lode Wyns; Alain Matagne; Carol V Robinson; Christina Redfield; Christopher M Dobson
Reduced global cooperativity is a common feature underlying the amyloidogenicity of pathogenic lysozyme mutations.
Journal of molecular biology 2005;346(3):773-88.
2005: Martino Calamai; Claudio Canale; Annalisa Relini; Massimo Stefani; Fabrizio Chiti; Christopher M Dobson
Reversal of protein aggregation provides evidence for multiple aggregated States.
Journal of molecular biology 2005;346(2):603-16.
2005: Michele Vendruscolo; Christopher M Dobson
Towards complete descriptions of the free-energy landscapes of proteins.
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences 2005;363(1827):433-50; discussion 450-2.
2005: Matthew M. Dedmon; Kresten Lindorff-Larsen; John Christodoulou; Michele Vendruscolo; Christopher M Dobson
Mapping long-range interactions in alpha-synuclein using spin-label NMR and ensemble molecular dynamics simulations.
Journal of the American Chemical Society 2005;127(2):476-7.
2005: Kresten Lindorff-Larsen; Robert B Best; Mark A DePristo; Christopher M Dobson; Michele Vendruscolo
Simultaneous determination of protein structure and dynamics.
Nature 2005;433(7022):128-32.
2005: Kresten Lindorff-Larsen; Peter Røgen; Emanuele Paci; Michele Vendruscolo; Christopher M Dobson
Protein folding and the organization of the protein topology universe.
Trends in biochemical sciences 2005;30(1):13-9.
2004: Christopher M Dobson
Chemical space and biology.
Nature 2004;432(7019):824-8.
2004: Mark R H Krebs; Cait E MacPhee; Aline F Miller; Iain E Dunlop; Christopher M Dobson; Athene M Donald
The formation of spherulites by amyloid fibrils of bovine insulin.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(40):14420-4.
2004: Mireille Dumoulin; Christopher M Dobson
Probing the origins, diagnosis and treatment of amyloid diseases using antibodies.
Biochimie 2004;86(9-10):589-600.
2004: Christopher M Dobson
Experimental investigation of protein folding and misfolding.
Methods (San Diego, Calif.) 2004;34(1):4-14.
2004: Kateri F DuBay; Amol P Pawar; Fabrizio Chiti; Jesús Zurdo; Christopher M Dobson; Michele Vendruscolo
Prediction of the absolute aggregation rates of amyloidogenic polypeptide chains.
Journal of molecular biology 2004;341(5):1317-26.
2004: Dmitry M Korzhnev; Xavier Salvatella; Michele Vendruscolo; Ariel A Di Nardo; Alan R Davidson; Christopher M Dobson; Lewis E Kay
Low-populated folding intermediates of Fyn SH3 characterized by relaxation dispersion NMR.
Nature 2004;430(6999):586-90.
2004: John Christodoulou; Göran Larsson; Paola Fucini; Sean connell; Thelma A Pertinhez; Charlotte L Hanson; Christina Redfield; Knud H Nierhaus; Carol V Robinson; Jürgen Schleucher; Christopher M Dobson
Heteronuclear NMR investigations of dynamic regions of intact Escherichia coli ribosomes.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(30):10949-54.
2004: Erica Frare; Patrizia Polverino De Laureto; Jesús Zurdo; Christopher M Dobson; Angelo Fontana
A highly amyloidogenic region of hen lysozyme.
Journal of molecular biology 2004;340(5):1153-65.
2004: monica bucciantini; Giulia Calloni; Fabrizio Chiti; Lucia Formigli; Daniele Nosi; Christopher M Dobson; Massimo Stefani
Prefibrillar amyloid protein aggregates share common features of cytotoxicity.
The Journal of biological chemistry 2004;279(30):31374-82.
2004: Mark R H Krebs; Ludmilla A Morozova-Roche; Katie Daniel; Carol V Robinson; Christopher M Dobson
Observation of sequence specificity in the seeding of protein amyloid fibrils.
Protein science : a publication of the Protein Society 2004;13(7):1933-8.
2004: Christopher M Dobson
Protein chemistry. In the footsteps of alchemists.
Science (New York, N.Y.) 2004;304(5675):1259-62.
2004: Caroline F Wright; John Christodoulou; Christopher M Dobson; Jane Clarke
The importance of loop length in the folding of an immunoglobulin domain.
Protein engineering, design & selection : PEDS 2004;17(5):443-53.
2004: Kresten Lindorff-Larsen; Michele Vendruscolo; Emanuele Paci; Christopher M Dobson
Transition states for protein folding have native topologies despite high structural variability.
Nature structural & molecular biology 2004;11(5):443-9.
2004: Cindy M Quezada; Brenda A Schulman; Joanna J Froggatt; Christopher M Dobson; Christina Redfield
Local and global cooperativity in the human alpha-lactalbumin molten globule.
Journal of molecular biology 2004;338(1):149-58.
2004: Robert J C Gilbert; Paola Fucini; Sean connell; Stephen D Fuller; Knud H Nierhaus; Carol V Robinson; Christopher M Dobson; David I Stuart
Three-dimensional structures of translating ribosomes by Cryo-EM.
Molecular cell 2004;14(1):57-66.
2004: Kresten Lindorff-Larsen; Sigridur Kristjansdottir; Kaare Teilum; Wolfgang Fieber; Christopher M Dobson; Flemming M Poulsen; Michele Vendruscolo
Determination of an ensemble of structures representing the denatured state of the bovine acyl-coenzyme a binding protein.
Journal of the American Chemical Society 2004;126(10):3291-9.
2004: Christopher M Dobson
Principles of protein folding, misfolding and aggregation.
Seminars in cell & developmental biology 2004;15(1):3-16.
2004: Sarah Meehan; Yoke Berry; Ben F Luisi; Christopher M Dobson; John A Carver; Cait E MacPhee
Amyloid fibril formation by lens crystallin proteins and its implications for cataract formation.
The Journal of biological chemistry 2004;279(5):3413-9.
2004: Christopher Jaroniec; Cait E MacPhee; Vikram S Bajaj; Michael McMahon; Christopher M Dobson; Robert G Griffin
High-resolution molecular structure of a peptide in an amyloid fibril determined by magic angle spinning NMR spectroscopy.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(3):711-6.
2003: Michele Vendruscolo; Emanuele Paci; Christopher M Dobson; Martin Karplus
Rare fluctuations of native proteins sampled by equilibrium hydrogen exchange.
Journal of the American Chemical Society 2003;125(51):15686-7.
2003: Marcus Fändrich; Vincent Forge; Katrin Buder; Marlis Kittler; Christopher M Dobson; Stephan Diekmann
Myoglobin forms amyloid fibrils by association of unfolded polypeptide segments.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(26):15463-8.
2003: Christopher M Dobson
Protein folding and misfolding.
Nature 2003;426(6968):884-90.
2003: Michele Vendruscolo; Emanuele Paci; Martin Karplus; Christopher M Dobson
Structures and relative free energies of partially folded states of proteins.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(25):14817-21.
2003: Patrizia Polverino De Laureto; Niccolò Taddei; Erica Frare; Cristina Capanni; Silvia Costantini; Jesús Zurdo; Fabrizio Chiti; Christopher M Dobson; Angelo Fontana
Protein aggregation and amyloid fibril formation by an SH3 domain probed by limited proteolysis.
Journal of molecular biology 2003;334(1):129-41.
2003: Melanie R Nilsson; Christopher M Dobson
Chemical modification of insulin in amyloid fibrils.
Protein science : a publication of the Protein Society 2003;12(11):2637-41.
2003: Massimo Stefani; Christopher M Dobson
Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution.
Journal of molecular medicine (Berlin, Germany) 2003;81(11):678-99.
2003: K Hun Mok; Toshio Nagashima; Iain J Day; Jonathan A Jones; Charles J V Jones; Christopher M Dobson; Peter J Hore
Rapid sample-mixing technique for transient NMR and photo-CIDNP spectroscopy: applications to real-time protein folding.
Journal of the American Chemical Society 2003;125(41):12484-92.
2003: Fabrizio Chiti; Massimo Stefani; Niccolò Taddei; Giampietro Ramponi; Christopher M Dobson
Rationalization of the effects of mutations on peptide and protein aggregation rates.
Nature 2003;424(6950):805-8.
2003: Mireille Dumoulin; Alexander M Last; Aline Desmyter; Klaas Decanniere; Denis Canet; Göran Larsson; Andrew Spencer; David B Archer; Jurgen Sasse; Serge Muyldermans; Lode Wyns; Christina Redfield; Alain Matagne; Carol V Robinson; Christopher M Dobson
A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme.
Nature 2003;424(6950):783-8.
2003: Kresten Lindorff-Larsen; Emanuele Paci; Luis Serrano; Christopher M Dobson; Michele Vendruscolo
Calculation of mutational free energy changes in transition states for protein folding.
Biophysical journal 2003;85(2):1207-14.
2003: Mantas Malisauskas; Vladimir Zamotin; Jana Jass; Wim Noppe; Christopher M Dobson; Ludmilla A Morozova-Roche
Amyloid protofilaments from the calcium-binding protein equine lysozyme: formation of ring and linear structures depends on pH and metal ion concentration.
Journal of molecular biology 2003;330(4):879-90.
2003: Denis Canet; Charles E Lyon; Ruud M Scheek; George T Robillard; Christopher M Dobson; Peter J Hore; Nico A J van Nuland
Rapid formation of non-native contacts during the folding of HPr revealed by real-time photo-CIDNP NMR and stopped-flow fluorescence experiments.
Journal of molecular biology 2003;330(2):397-407.
2003: Michele Vendruscolo; Jesús Zurdo; Cait E MacPhee; Christopher M Dobson
Protein folding and misfolding: a paradigm of self-assembly and regulation in complex biological systems.
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences 2003;361(1807):1205-22.
2003: Ana I Azuaga; Denis Canet; Gerard Smeenk; Roel Berends; Fritz Titgemeijer; Ria H Duurkens; Pedro L Mateo; Ruud M Scheek; George T Robillard; Christopher M Dobson; Nico A J van Nuland
Characterization of single-tryptophan mutants of histidine-containing phosphocarrier protein: evidence for local rearrangements during folding from high concentrations of denaturant.
Biochemistry 2003;42(17):4883-95.
2003: Yuji O Kamatari; Christopher M Dobson; Takashi Konno
Structural dissection of alkaline-denatured pepsin.
Protein science : a publication of the Protein Society 2003;12(4):717-24.
2003: Christopher M Dobson
Protein folding and disease: a view from the first Horizon Symposium.
Nature reviews. Drug discovery 2003;2(2):154-60.
2003: Melanie R Nilsson; Christopher M Dobson
In vitro characterization of lactoferrin aggregation and amyloid formation.
Biochemistry 2003;42(2):375-82.
2002: Christopher Jaroniec; Cait E MacPhee; Nathan S Astrof; Christopher M Dobson; Robert G Griffin
Molecular conformation of a peptide fragment of transthyretin in an amyloid fibril.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(26):16748-53.
2002: Fabrizio Chiti; Martino Calamai; Niccolò Taddei; Massimo Stefani; Giampietro Ramponi; Christopher M Dobson
Studies of the aggregation of mutant proteins in vitro provide insights into the genetics of amyloid diseases.
Proceedings of the National Academy of Sciences of the United States of America 2002;99 Suppl 4():16419-26.
2002: Charles E Lyon; Eui-Sik Suh; Christopher M Dobson; Peter J Hore
Probing the exposure of tyrosine and tryptophan residues in partially folded proteins and folding intermediates by CIDNP pulse-labeling.
Journal of the American Chemical Society 2002;124(44):13018-24.
2002: Marcus Fändrich; Christopher M Dobson
The behaviour of polyamino acids reveals an inverse side chain effect in amyloid structure formation.
The EMBO journal 2002;21(21):5682-90.
2002: Thelma A Pertinhez; Mario Bouchard; Richard A G Smith; Christopher M Dobson; Lorna J Smith
Stimulation and inhibition of fibril formation by a peptide in the presence of different concentrations of SDS.
FEBS letters 2002;529(2-3):193-7.
2002: Christopher M Dobson
Getting out of shape.
Nature 2002;418(6899):729-30.
2002: Ana I Azuaga; Christopher M Dobson; Pedro L Mateo; Francisco Conejero-Lara
Unfolding and aggregation during the thermal denaturation of streptokinase.
European journal of biochemistry / FEBS 2002;269(16):4121-33.
2002: José L Jiménez; Ewan J Nettleton; Mario Bouchard; Carol V Robinson; Christopher M Dobson; Helen R Saibil
The protofilament structure of insulin amyloid fibrils.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(14):9196-201.
2002: John A Carver; Robyn A Lindner; Charles Lyon; Denis Canet; Helena Hernandez; Christopher M Dobson; Christina Redfield
The interaction of the molecular chaperone alpha-crystallin with unfolding alpha-lactalbumin: a structural and kinetic spectroscopic study.
Journal of molecular biology 2002;318(3):815-27.
2002: Denis Canet; Alexander M Last; Paula Tito; Margaret Sunde; Andrew Spencer; David B Archer; Christina Redfield; Carol V Robinson; Christopher M Dobson
Local cooperativity in the unfolding of an amyloidogenic variant of human lysozyme.
Nature structural biology 2002;9(4):308-15.
2002: Judith Klein-Seetharaman; Maki Oikawa; Shaun B Grimshaw; Julia Wirmer; Elke Duchardt; Tadashi Ueda; Taiji Imoto; Lorna J Smith; Christopher M Dobson; Harald Schwalbe
Long-range interactions within a nonnative protein.
Science (New York, N.Y.) 2002;295(5560):1719-22.
2002: Fabrizio Chiti; Niccolò Taddei; Fabiana Baroni; Cristina Capanni; Massimo Stefani; Giampietro Ramponi; Christopher M Dobson
Kinetic partitioning of protein folding and aggregation.
Nature structural biology 2002;9(2):137-43.
2001: Fabrizio Chiti; Ersilia De Lorenzi; Silvia Grossi; Palma Mangione; Sofia Giorgetti; Gabriele Caccialanza; Christopher M Dobson; Giampaolo Merlini; Giampietro Ramponi; Vittorio Bellotti
A partially structured species of beta 2-microglobulin is significantly populated under physiological conditions and involved in fibrillogenesis.
The Journal of biological chemistry 2001;276(50):46714-21.
2001: Rachel Wain; Thelma A Pertinhez; Esther J Tomlinson; L Hong; Christopher M Dobson; Stuart J Ferguson; Lorna J Smith
The cytochrome c fold can be attained from a compact apo state by occupancy of a nascent heme binding site.
The Journal of biological chemistry 2001;276(49):45813-7.
2001: Fabrizio Chiti; monica bucciantini; Cristina Capanni; Niccolò Taddei; Christopher M Dobson; Massimo Stefani
Solution conditions can promote formation of either amyloid protofilaments or mature fibrils from the HypF N-terminal domain.
Protein science : a publication of the Protein Society 2001;10(12):2541-7.
2001: A K Chamberlain; Veronique Receveur-Brechot; Andrew Spencer; Christina Redfield; Christopher M Dobson
Characterization of the structure and dynamics of amyloidogenic variants of human lysozyme by NMR spectroscopy.
Protein science : a publication of the Protein Society 2001;10(12):2525-30.
2001: Niccolò Taddei; Cristina Capanni; Fabrizio Chiti; Massimo Stefani; Christopher M Dobson; Giampietro Ramponi
Folding and aggregation are selectively influenced by the conformational preferences of the alpha-helices of muscle acylphosphatase.
The Journal of biological chemistry 2001;276(40):37149-54.
2001: Ramani Wijesinha-Bettoni; Christopher M Dobson; Christina Redfield
Comparison of the denaturant-induced unfolding of the bovine and human alpha-lactalbumin molten globules.
Journal of molecular biology 2001;312(1):261-73.
2001: Jesús Zurdo; JI Guijarro; Christopher M Dobson
Preparation and characterization of purified amyloid fibrils.
Journal of the American Chemical Society 2001;123(33):8141-2.
2001: Jesús Zurdo; JI Guijarro; José L Jiménez; Helen R Saibil; Christopher M Dobson
Dependence on solution conditions of aggregation and amyloid formation by an SH3 domain.
Journal of molecular biology 2001;311(2):325-40.
2001: Thelma A Pertinhez; Mario Bouchard; Esther J Tomlinson; Rachel Wain; Stuart J Ferguson; Christopher M Dobson; Lorna J Smith
Amyloid fibril formation by a helical cytochrome.
FEBS letters 2001;495(3):184-6.
2001: Fabrizio Chiti; Niccolò Taddei; Massimo Stefani; Christopher M Dobson; Giampietro Ramponi
Reduction of the amyloidogenicity of a protein by specific binding of ligands to the native conformation.
Protein science : a publication of the Protein Society 2001;10(4):879-86.
2001: Harald Schwalbe; Shaun B Grimshaw; Andrew Spencer; M Buck; J Boyd; Christopher M Dobson; Christina Redfield; Lorna J Smith
A refined solution structure of hen lysozyme determined using residual dipolar coupling data.
Protein science : a publication of the Protein Society 2001;10(4):677-88.
2001: Denis Canet; K Doering; Christopher M Dobson; Y Dupont
High-sensitivity fluorescence anisotropy detection of protein-folding events: application to alpha-lactalbumin.
Biophysical journal 2001;80(4):1996-2003.
2001: Ramani Wijesinha-Bettoni; Christopher M Dobson; Christina Redfield
Comparison of the structural and dynamical properties of holo and apo bovine alpha-lactalbumin by NMR spectroscopy.
Journal of molecular biology 2001;307(3):885-98.
2001: Fabrizio Chiti; Palma Mangione; Alessia Andreola; Sofia Giorgetti; Massimo Stefani; Christopher M Dobson; Vittorio Bellotti; Niccolò Taddei
Detection of two partially structured species in the folding process of the amyloidogenic protein beta 2-microglobulin.
Journal of molecular biology 2001;307(1):379-91.
2001: Marcus Fändrich; M A Fletcher; Christopher M Dobson
Amyloid fibrils from muscle myoglobin.
Nature 2001;410(6825):165-6.
2001: Yuji O Kamatari; H Yamada; Kazuyuki Akasaka; J A Jones; Christopher M Dobson; Lorna J Smith
Response of native and denatured hen lysozyme to high pressure studied by (15)N/(1)H NMR spectroscopy.
European journal of biochemistry / FEBS 2001;268(6):1782-93.
2001: E Paci; Lorna J Smith; Christopher M Dobson; M Karplus
Exploration of partially unfolded states of human alpha-lactalbumin by molecular dynamics simulation.
Journal of molecular biology 2001;306(2):329-47.
2001: Michele Vendruscolo; E Paci; Christopher M Dobson; M Karplus
Three key residues form a critical contact network in a protein folding transition state.
Nature 2001;409(6820):641-5.
2000: Marcus Fändrich; MA Tito; MR Leroux; A A Rostom; F Ulrich Hartl; Christopher M Dobson; Carol V Robinson
Observation of the noncovalent assembly and disassembly pathways of the chaperone complex MtGimC by mass spectrometry.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(26):14151-5.
2000: A K Chamberlain; Cait E MacPhee; Jesús Zurdo; Ludmilla A Morozova-Roche; H Allen O Hill; Christopher M Dobson; Jason J Davis
Ultrastructural organization of amyloid fibrils by atomic force microscopy.
Biophysical journal 2000;79(6):3282-93.
2000: Christopher M Dobson; G B Ellison; A F Tuck; V Vaida
Atmospheric aerosols as prebiotic chemical reactors.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):11864-8.
2000: Mario Bouchard; Jesús Zurdo; Ewan J Nettleton; Christopher M Dobson; Carol V Robinson
Formation of insulin amyloid fibrils followed by FTIR simultaneously with CD and electron microscopy.
Protein science : a publication of the Protein Society 2000;9(10):1960-7.
2000: Thelma A Pertinhez; Daizo Hamada; Lorna J Smith; Fabrizio Chiti; Niccolò Taddei; Massimo Stefani; Christopher M Dobson
Initial denaturing conditions influence the slow folding phase of acylphosphatase associated with proline isomerization.
Protein science : a publication of the Protein Society 2000;9(8):1466-73.
2000: B van den Berg; Rachel Wain; Christopher M Dobson; RJ Ellis
Macromolecular crowding perturbs protein refolding kinetics: implications for folding inside the cell.
The EMBO journal 2000;19(15):3870-5.
2000: Ewan J Nettleton; Paula Tito; Margaret Sunde; Mario Bouchard; Christopher M Dobson; Carol V Robinson
Characterization of the oligomeric states of insulin in self-assembly and amyloid fibril formation by mass spectrometry.
Biophysical journal 2000;79(2):1053-65.
2000: Niccolò Taddei; Fabrizio Chiti; Tania Fiaschi; monica bucciantini; Cristina Capanni; Massimo Stefani; L Serrano; Christopher M Dobson; Giampietro Ramponi
Stabilisation of alpha-helices by site-directed mutagenesis reveals the importance of secondary structure in the transition state for acylphosphatase folding.
Journal of molecular biology 2000;300(3):633-47.
2000: M R Krebs; DK Wilkins; EW Chung; MC Pitkeathly; A K Chamberlain; Jesús Zurdo; Carol V Robinson; Christopher M Dobson
Formation and seeding of amyloid fibrils from wild-type hen lysozyme and a peptide fragment from the beta-domain.
Journal of molecular biology 2000;300(3):541-9.
2000: AR Dinner; Andrej Sali; L J Smith; Christopher M Dobson; M Karplus
Understanding protein folding via free-energy surfaces from theory and experiment.
Trends in biochemical sciences 2000;25(7):331-9.
2000: CJ Morgan; DK Wilkins; Lorna J Smith; Y Kawata; Christopher M Dobson
A compact monomeric intermediate identified by NMR in the denaturation of dimeric triose phosphate isomerase.
Journal of molecular biology 2000;300(1):11-6.
2000: Ludmilla A Morozova-Roche; Jesús Zurdo; Andrew Spencer; Wim Noppe; Veronique Receveur-Brechot; David B Archer; M Joniau; Christopher M Dobson
Amyloid fibril formation and seeding by wild-type human lysozyme and its disease-related mutational variants.
Journal of structural biology 2000;130(2-3):339-51.
2000: A A Rostom; Paola Fucini; DR Benjamin; R Juenemann; Knud H Nierhaus; F Ulrich Hartl; Christopher M Dobson; Carol V Robinson
Detection and selective dissociation of intact ribosomes in a mass spectrometer.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5185-90.
2000: DK Wilkins; Christopher M Dobson; M Gross
Biophysical studies of the development of amyloid fibrils from a peptide fragment of cold shock protein B.
European journal of biochemistry / FEBS 2000;267(9):2609-16.
2000: Cait E MacPhee; Christopher M Dobson
Chemical dissection and reassembly of amyloid fibrils formed by a peptide fragment of transthyretin.
Journal of molecular biology 2000;297(5):1203-15.
2000: Fabrizio Chiti; Niccolò Taddei; monica bucciantini; P White; Giampietro Ramponi; Christopher M Dobson
Mutational analysis of the propensity for amyloid formation by a globular protein.
The EMBO journal 2000;19(7):1441-9.
2000: CJ Penkett; Christopher M Dobson; Lorna J Smith; JR Bright; Andrew R Pickford; Iain D Campbell; Jennifer R Potts
Identification of residues involved in the interaction of Staphylococcus aureus fibronectin-binding protein with the (4)F1(5)F1 module pair of human fibronectin using heteronuclear NMR spectroscopy.
Biochemistry 2000;39(11):2887-93.
2000: A Matagne; M Jamin; EW Chung; Carol V Robinson; SE Radford; Christopher M Dobson
Thermal unfolding of an intermediate is associated with non-Arrhenius kinetics in the folding of hen lysozyme.
Journal of molecular biology 2000;297(1):193-210.
2000: K Maeda; Charles E Lyon; Jakob J Lopez; M Cemazar; Christopher M Dobson; Peter J Hore
Improved photo-CIDNP methods for studying protein structure and folding.
Journal of biomolecular NMR 2000;16(3):235-44.
2000: Mario Bouchard; DR Benjamin; Paula Tito; Carol V Robinson; Christopher M Dobson
Solvent effects on the conformation of the transmembrane peptide gramicidin A: insights from electrospray ionization mass spectrometry.
Biophysical journal 2000;78(2):1010-7.
2000: Daizo Hamada; Fabrizio Chiti; J I Guijarro; M Kataoka; Niccolò Taddei; Christopher M Dobson
Evidence concerning rate-limiting steps in protein folding from the effects of trifluoroethanol.
Nature structural biology 2000;7(1):58-61.
1999: B van den Berg; RJ Ellis; Christopher M Dobson
Effects of macromolecular crowding on protein folding and aggregation.
The EMBO journal 1999;18(24):6927-33.
1999: DK Wilkins; Shaun B Grimshaw; Veronique Receveur-Brechot; Christopher M Dobson; JA Jones; Lorna J Smith
Hydrodynamic radii of native and denatured proteins measured by pulse field gradient NMR techniques.
Biochemistry 1999;38(50):16424-31.
1999: MR Leroux; Marcus Fändrich; Daniel Klunker; Katja Siegers; Andrei N Lupas; J R Brown; Elmar Schiebel; Christopher M Dobson; F Ulrich Hartl
MtGimC, a novel archaeal chaperone related to the eukaryotic chaperonin cofactor GimC/prefoldin.
The EMBO journal 1999;18(23):6730-43.
1999: Fabrizio Chiti; Niccolò Taddei; P M White; monica bucciantini; Francesca Magherini; Massimo Stefani; Christopher M Dobson
Mutational analysis of acylphosphatase suggests the importance of topology and contact order in protein folding.
Nature structural biology 1999;6(11):1005-9.
1999: Christina Redfield; Brenda A Schulman; M A Milhollen; Peter S Kim; Christopher M Dobson
Alpha-lactalbumin forms a compact molten globule in the absence of disulfide bonds.
Nature structural biology 1999;6(10):948-52.
1999: Christopher M Dobson
Protein misfolding, evolution and disease.
Trends in biochemical sciences 1999;24(9):329-32.
1999: B van den Berg; EW Chung; Carol V Robinson; P L Mateo; Christopher M Dobson
The oxidative refolding of hen lysozyme and its catalysis by protein disulfide isomerase.
The EMBO journal 1999;18(17):4794-803.
1999: Fabrizio Chiti; Niccolò Taddei; Elisa Giannoni; Nico A J van Nuland; Giampietro Ramponi; Christopher M Dobson
Development of enzymatic activity during protein folding. Detection of a spectroscopically silent native-like intermediate of muscle acylphosphatase.
The Journal of biological chemistry 1999;274(29):20151-8.
1999: B van den Berg; EW Chung; Carol V Robinson; Christopher M Dobson
Characterisation of the dominant oxidative folding intermediate of hen lysozyme.
Journal of molecular biology 1999;290(3):781-96.
1999: Lorna J Smith; Christopher M Dobson; Wilfred F van Gunsteren
Molecular dynamics simulations of human alpha-lactalbumin: changes to the structural and dynamical properties of the protein at low pH.
Proteins 1999;36(1):77-86.
1999: Ludmilla A Morozova-Roche; J A Jones; Wim Noppe; Christopher M Dobson
Independent nucleation and heterogeneous assembly of structure during folding of equine lysozyme.
Journal of molecular biology 1999;289(4):1055-73.
1999: H Vis; Christopher M Dobson; Carol V Robinson
Selective association of protein molecules followed by mass spectrometry.
Protein science : a publication of the Protein Society 1999;8(6):1368-70.
1999: M Gross; DK Wilkins; MC Pitkeathly; EW Chung; Christopher W Higham; A Clark; Christopher M Dobson
Formation of amyloid fibrils by peptides derived from the bacterial cold shock protein CspB.
Protein science : a publication of the Protein Society 1999;8(6):1350-7.
1999: Andrew Spencer; L A Morozov-Roche; Wim Noppe; Donald A MacKenzie; David J Jeenes; M Joniau; Christopher M Dobson; David B Archer
Expression, purification, and characterization of the recombinant calcium-binding equine lysozyme secreted by the filamentous fungus Aspergillus niger: comparisons with the production of hen and human lysozymes.
Protein expression and purification 1999;16(1):171-80.
1999: Denis Canet; Margaret Sunde; Alexander M Last; Andrew D Miranker; Andrew Spencer; Carol V Robinson; Christopher M Dobson
Mechanistic studies of the folding of human lysozyme and the origin of amyloidogenic behavior in its disease-related variants.
Biochemistry 1999;38(20):6419-27.
1999: Mirko Hennig; Wolfgang Bermel; A Spencer; Christopher M Dobson; L J Smith; Harald Schwalbe
Side-chain conformations in an unfolded protein: chi1 distributions in denatured hen lysozyme determined by heteronuclear 13C, 15N NMR spectroscopy.
Journal of molecular biology 1999;288(4):705-23.
1999: V Forge; R T Wijesinha; J Balbach; K Brew; Carol V Robinson; Christina Redfield; Christopher M Dobson
Rapid collapse and slow structural reorganisation during the refolding of bovine alpha-lactalbumin.
Journal of molecular biology 1999;288(4):673-88.
1999: Fabrizio Chiti; Niccolò Taddei; P Webster; Daizo Hamada; Tania Fiaschi; Giampietro Ramponi; Christopher M Dobson
Acceleration of the folding of acylphosphatase by stabilization of local secondary structure.
Nature structural biology 1999;6(4):380-7.
1999: Fabrizio Chiti; P Webster; Niccolò Taddei; Anne Clark; Massimo Stefani; Giampietro Ramponi; Christopher M Dobson
Designing conditions for in vitro formation of amyloid protofilaments and fibrils.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):3590-4.
1999: Lorna J Smith; Christopher M Dobson; Wilfred F van Gunsteren
Side-chain conformational disorder in a molten globule: molecular dynamics simulations of the A-state of human alpha-lactalbumin.
Journal of molecular biology 1999;286(5):1567-80.
1999: Niccolò Taddei; Fabrizio Chiti; Paola Paoli; Tania Fiaschi; monica bucciantini; Massimo Stefani; Christopher M Dobson; Giampietro Ramponi
Thermodynamics and kinetics of folding of common-type acylphosphatase: comparison to the highly homologous muscle isoenzyme.
Biochemistry 1999;38(7):2135-42.
1999: José L Jiménez; J I Guijarro; Elena V Orlova; Jesús Zurdo; Christopher M Dobson; M Sunde; Helen R Saibil
Cryo-electron microscopy structure of an SH3 amyloid fibril and model of the molecular packing.
The EMBO journal 1999;18(4):815-21.
1999: Ana I Azuaga; N D Woodruff; Francisco Conejero-Lara; V F Cox; Richard A G Smith; Christopher M Dobson
Expression and characterization of the intact N-terminal domain of streptokinase.
Protein science : a publication of the Protein Society 1999;8(2):443-6.
1999: Christopher M Dobson; M Karplus
The fundamentals of protein folding: bringing together theory and experiment.
Current opinion in structural biology 1999;9(1):92-101.
1998: CJ Penkett; Christina Redfield; JA Jones; I Dodd; J Hubbard; R A G Smith; Lorna J Smith; Christopher M Dobson
Structural and dynamical characterization of a biologically active unfolded fibronectin-binding protein from Staphylococcus aureus.
Biochemistry 1998;37(48):17054-67.
1998: Fabrizio Chiti; Niccolò Taddei; Nico A J van Nuland; Francesca Magherini; Massimo Stefani; Giampietro Ramponi; Christopher M Dobson
Structural characterization of the transition state for folding of muscle acylphosphatase.
Journal of molecular biology 1998;283(4):893-903.
1998: Nico A J van Nuland; Fabrizio Chiti; Niccolò Taddei; Giovanni Raugei; Giampietro Ramponi; Christopher M Dobson
Slow folding of muscle acylphosphatase in the absence of intermediates.
Journal of molecular biology 1998;283(4):883-91.
1998: Francisco Conejero-Lara; J Parrado; Ana I Azuaga; Christopher M Dobson; CP Ponting
Analysis of the interactions between streptokinase domains and human plasminogen.
Protein science : a publication of the Protein Society 1998;7(10):2190-9.
1998: Christopher M Dobson; RJ Ellis
Protein folding and misfolding inside and outside the cell.
The EMBO journal 1998;17(18):5251-4.
1998: Ewan J Nettleton; Margaret Sunde; Z Lai; J W Kelly; Christopher M Dobson; Carol V Robinson
Protein subunit interactions and structural integrity of amyloidogenic transthyretins: evidence from electrospray mass spectrometry.
Journal of molecular biology 1998;281(3):553-64.
1998: Lorna J Smith; A E Mark; Christopher M Dobson; Wilfred F van Gunsteren
Molecular dynamics simulations of peptide fragments from hen lysozyme: insight into non-native protein conformations.
Journal of molecular biology 1998;280(4):703-19.
1998: Fabrizio Chiti; Francesca Magherini; Niccolò Taddei; C Ilardi; Massimo Stefani; monica bucciantini; Christopher M Dobson; Giampietro Ramponi
Studies on enzymatic activity and conformational stability of muscle acylphosphatase mutated at conserved lysine residues.
Protein engineering 1998;11(7):557-61.
1998: Christopher M Dobson; P J Hore
Kinetic studies of protein folding using NMR spectroscopy.
Nature structural biology 1998;5 Suppl():504-7.
1998: DR Benjamin; Carol V Robinson; J P Hendrick; F Ulrich Hartl; Christopher M Dobson
Mass spectrometry of ribosomes and ribosomal subunits.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(13):7391-5.
1998: CJ Morgan; Andrew D Miranker; Christopher M Dobson
Characterization of collapsed states in the early stages of the refolding of hen lysozyme.
Biochemistry 1998;37(23):8473-80.
1998: A Matagne; EW Chung; Linda J Ball; SE Radford; Carol V Robinson; Christopher M Dobson
The origin of the alpha-domain intermediate in the folding of hen lysozyme.
Journal of molecular biology 1998;277(5):997-1005.
1998: J I Guijarro; Margaret Sunde; J A Jones; Iain D Campbell; Christopher M Dobson
Amyloid fibril formation by an SH3 domain.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(8):4224-8.
1998: A Matagne; Christopher M Dobson
The folding process of hen lysozyme: a perspective from the 'new view'.
Cellular and molecular life sciences : CMLS 1998;54(4):363-71.
1998: H H de Jongh; S Rospert; Christopher M Dobson
Comparison of the conformational state and in vitro refolding of yeast chaperonin protein cpn10 with bacterial GroES.
Biochemical and biophysical research communications 1998;244(3):884-8.
1998: JI Guijarro; CJ Morton; KW Plaxco; Iain D Campbell; Christopher M Dobson
Folding kinetics of the SH3 domain of PI3 kinase by real-time NMR combined with optical spectroscopy.
Journal of molecular biology 1998;276(3):657-67.
1998: KW Plaxco; JI Guijarro; CJ Morton; MC Pitkeathly; Iain D Campbell; Christopher M Dobson
The folding kinetics and thermodynamics of the Fyn-SH3 domain.
Biochemistry 1998;37(8):2529-37.
1998: Fabrizio Chiti; Nico A J van Nuland; Niccolò Taddei; Francesca Magherini; Massimo Stefani; Giampietro Ramponi; Christopher M Dobson
Conformational stability of muscle acylphosphatase: the role of temperature, denaturant concentration, and pH.
Biochemistry 1998;37(5):1447-55.
1998: Nico A J van Nuland; Wim Meijberg; J Warner; V Forge; Ruud M Scheek; George T Robillard; Christopher M Dobson
Slow cooperative folding of a small globular protein HPr.
Biochemistry 1998;37(2):622-37.
1998: A A Rostom; Margaret Sunde; S J Richardson; G Schreiber; S Jarvis; R Bateman; Christopher M Dobson; Carol V Robinson
Dissection of multi-protein complexes using mass spectrometry: subunit interactions in transthyretin and retinol-binding protein complexes.
Proteins 1998;Suppl 2():3-11.
1997: CJ Penkett; Christina Redfield; I Dodd; J Hubbard; DL McBay; DE Mossakowska; R A G Smith; Christopher M Dobson; Lorna J Smith
NMR analysis of main-chain conformational preferences in an unfolded fibronectin-binding protein.
Journal of molecular biology 1997;274(2):152-9.
1997: KW Plaxco; CJ Morton; Shaun B Grimshaw; JA Jones; MC Pitkeathly; Iain D Campbell; Christopher M Dobson
The effects of guanidine hydrochloride on the 'random coil' conformations and NMR chemical shifts of the peptide series GGXGG.
Journal of biomolecular NMR 1997;10(3):221-30.
1997: Brenda A Schulman; Peter S Kim; Christopher M Dobson; Christina Redfield
A residue-specific NMR view of the non-cooperative unfolding of a molten globule.
Nature structural biology 1997;4(8):630-4.
1997: KW Plaxco; C Spitzfaden; Iain D Campbell; Christopher M Dobson
A comparison of the folding kinetics and thermodynamics of two homologous fibronectin type III modules.
Journal of molecular biology 1997;270(5):763-70.
1997: Harald Schwalbe; Klaus M Fiebig; M Buck; JA Jones; Shaun B Grimshaw; Andrew Spencer; S J Glaser; Lorna J Smith; Christopher M Dobson
Structural and dynamical properties of a denatured protein. Heteronuclear 3D NMR experiments and theoretical simulations of lysozyme in 8 M urea.
Biochemistry 1997;36(29):8977-91.
1997: J Balbach; V Forge; W S Lau; J A Jones; Nico A J van Nuland; Christopher M Dobson
Detection of residue contacts in a protein folding intermediate.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(14):7182-5.
1997: EW Chung; Ewan J Nettleton; CJ Morgan; M Gross; Andrew D Miranker; SE Radford; Christopher M Dobson; Carol V Robinson
Hydrogen exchange properties of proteins in native and denatured states monitored by mass spectrometry and NMR.
Protein science : a publication of the Protein Society 1997;6(6):1316-24.
1997: Ludmilla A Morozova-Roche; C C Arico-Muendel; D T Haynie; V I Emelyanenko; H Van Dael; Christopher M Dobson
Structural characterisation and comparison of the native and A-states of equine lysozyme.
Journal of molecular biology 1997;268(5):903-21.
1997: A Matagne; SE Radford; Christopher M Dobson
Fast and slow tracks in lysozyme folding: insight into the role of domains in the folding process.
Journal of molecular biology 1997;267(5):1068-74.
1997: Christopher M Dobson; O B Ptitsyn
Folding and binding. From theory to therapy.
Current opinion in structural biology 1997;7(1):1-2.
1997: Hui Lu; M Buck; SE Radford; Christopher M Dobson
Acceleration of the folding of hen lysozyme by trifluoroethanol.
Journal of molecular biology 1997;265(2):112-7.
1996: Francisco Conejero-Lara; J Parrado; Ana I Azuaga; R A G Smith; C P Ponting; Christopher M Dobson
Thermal stability of the three domains of streptokinase studied by circular dichroism and nuclear magnetic resonance.
Protein science : a publication of the Protein Society 1996;5(12):2583-91.
1996: J Balbach; V Forge; W S Lau; Nico A J van Nuland; K Brew; Christopher M Dobson
Protein folding monitored at individual residues during a two-dimensional NMR experiment.
Science (New York, N.Y.) 1996;274(5290):1161-3.
1996: K W Plaxco; Christopher M Dobson
Time-resolved biophysical methods in the study of protein folding.
Current opinion in structural biology 1996;6(5):630-6.
1996: K W Plaxco; C Spitzfaden; Iain D Campbell; Christopher M Dobson
Rapid refolding of a proline-rich all-beta-sheet fibronectin type III module.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(20):10703-6.
1996: J Parrado; Kepa Escuredo; Francisco Conejero-Lara; M Kotik; C P Ponting; Juan A Asenjo; Christopher M Dobson
Molecular characterisation of a thermoactive beta-1,3-glucanase from Oerskovia xanthineolytica.
Biochimica et biophysica acta 1996;1296(2):145-51.
1996: K A Bolin; MC Pitkeathly; Andrew D Miranker; Lorna J Smith; Christopher M Dobson
Insight into a random coil conformation and an isolated helix: structural and dynamical characterisation of the C-helix peptide from hen lysozyme.
Journal of molecular biology 1996;261(3):443-53.
1996: M Buck; Harald Schwalbe; Christopher M Dobson
Main-chain dynamics of a partially folded protein: 15N NMR relaxation measurements of hen egg white lysozyme denatured in trifluoroethanol.
Journal of molecular biology 1996;257(3):669-83.
1996: J Parrado; Francisco Conejero-Lara; R A G Smith; J M Marshall; C P Ponting; Christopher M Dobson
The domain organization of streptokinase: nuclear magnetic resonance, circular dichroism, and functional characterization of proteolytic fragments.
Protein science : a publication of the Protein Society 1996;5(4):693-704.
1996: Andrew D Miranker; Christopher M Dobson
Collapse and cooperativity in protein folding.
Current opinion in structural biology 1996;6(1):31-42.
1996: Lorna J Smith; K A Bolin; Harald Schwalbe; M W MacArthur; J M Thornton; Christopher M Dobson
Analysis of main chain torsion angles in proteins: prediction of NMR coupling constants for native and random coil conformations.
Journal of molecular biology 1996;255(3):494-506.
1996: Jenny J Yang; B van den Berg; MC Pitkeathly; Lorna J Smith; K A Bolin; Timothy A Keiderling; Christina Redfield; Christopher M Dobson; S E Radford
Native-like secondary structure in a peptide from the alpha-domain of hen lysozyme.
Folding & design 1996;1(6):473-84.
1996: Lorna J Smith; Klaus M Fiebig; Harald Schwalbe; Christopher M Dobson
The concept of a random coil. Residual structure in peptides and denatured proteins.
Folding & design 1996;1(5):R95-106.
1996: Andrew D Miranker; Carol V Robinson; S E Radford; Christopher M Dobson
Investigation of protein folding by mass spectrometry.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(1):93-101.
1995: Brenda A Schulman; Christina Redfield; Zheng-Yu Peng; Christopher M Dobson; Peter S Kim
Different subdomains are most protected from hydrogen exchange in the molten globule and native states of human alpha-lactalbumin.
Journal of molecular biology 1995;253(5):651-7.
1995: M Buck; Harald Schwalbe; Christopher M Dobson
Characterization of conformational preferences in a partly folded protein by heteronuclear NMR spectroscopy: assignment and secondary structure analysis of hen egg-white lysozyme in trifluoroethanol.
Biochemistry 1995;34(40):13219-32.
1995: L A Morozova; D T Haynie; C Arico-Muendel; Herman Van Dael; Christopher M Dobson
Structural basis of the stability of a lysozyme molten globule.
Nature structural biology 1995;2(10):871-5.
1995: J Balbach; V Forge; Nico A J van Nuland; S L Winder; P J Hore; Christopher M Dobson
Following protein folding in real time using NMR spectroscopy.
Nature structural biology 1995;2(10):865-70.
1995: Jenny J Yang; M Buck; MC Pitkeathly; M Kotik; D T Haynie; Christopher M Dobson; S E Radford
Conformational properties of four peptides spanning the sequence of hen lysozyme.
Journal of molecular biology 1995;252(4):483-91.
1995: Lorna J Smith; Alan E Mark; Christopher M Dobson; Wilfred F van Gunsteren
Comparison of MD simulations and NMR experiments for hen lysozyme. Analysis of local fluctuations, cooperative motions, and global changes.
Biochemistry 1995;34(34):10918-31.
1995: G Spraggon; C Phillips; U K Nowak; C P Ponting; D Saunders; Christopher M Dobson; David I Stuart; E Yvonne Jones
The crystal structure of the catalytic domain of human urokinase-type plasminogen activator.
Structure (London, England : 1993) 1995;3(7):681-91.
1995: E Pardon; Petra Haezebrouck; A De Baetselier; S D Hooke; K T Fancourt; Johan Desmet; Christopher M Dobson; Herman Van Dael; Marcel Joniau
A Ca(2+)-binding chimera of human lysozyme and bovine alpha-lactalbumin that can form a molten globule.
The Journal of biological chemistry 1995;270(18):10514-24.
1995: S E Radford; Christopher M Dobson
Insights into protein folding using physical techniques: studies of lysozyme and alpha-lactalbumin.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1995;348(1323):17-25.
1995: M Buck; J Boyd; Christina Redfield; Donald A MacKenzie; David J Jeenes; David B Archer; Christopher M Dobson
Structural determinants of protein dynamics: analysis of 15N NMR relaxation measurements for main-chain and side-chain nuclei of hen egg white lysozyme.
Biochemistry 1995;34(12):4041-55.
1995: Petra Haezebrouck; Marcel Joniau; Herman Van Dael; S D Hooke; N D Woodruff; Christopher M Dobson
An equilibrium partially folded state of human lysozyme at low pH.
Journal of molecular biology 1995;246(3):382-7.
1995: M Kotik; S E Radford; Christopher M Dobson
Comparison of the refolding of hen lysozyme from dimethyl sulfoxide and guanidinium chloride.
Biochemistry 1995;34(5):1714-24.
1994: Carol V Robinson; M Gross; S J Eyles; J J Ewbank; M Mayhew; F Ulrich Hartl; Christopher M Dobson; S E Radford
Conformation of GroEL-bound alpha-lactalbumin probed by mass spectrometry.
Nature 1994;372(6507):646-51.
1994: A T Hadfield; David Harvey; David B Archer; Donald A MacKenzie; David J Jeenes; S E Radford; Gordon Lowe; Christopher M Dobson; Louise N Johnson
Crystal structure of the mutant D52S hen egg white lysozyme with an oligosaccharide product.
Journal of molecular biology 1994;243(5):856-72.
1994: S J Eyles; S E Radford; Carol V Robinson; Christopher M Dobson
Kinetic consequences of the removal of a disulfide bridge on the folding of hen lysozyme.
Biochemistry 1994;33(44):13038-48.
1994: Niccolò Taddei; M Buck; R W Broadhurst; Massimo Stefani; Giampietro Ramponi; Christopher M Dobson
Equilibrium unfolding studies of horse muscle acylphosphatase.
European journal of biochemistry / FEBS 1994;225(3):811-7.
1994: Lorna J Smith; A T Alexandrescu; MC Pitkeathly; Christopher M Dobson
Solution structure of a peptide fragment of human alpha-lactalbumin in trifluoroethanol: a model for local structure in the molten globule.
Structure (London, England : 1993) 1994;2(8):703-12.
1994: S D Hooke; S E Radford; Christopher M Dobson
The refolding of human lysozyme: a comparison with the structurally homologous hen lysozyme.
Biochemistry 1994;33(19):5867-76.
1994: LS Itzhaki; P A Evans; Christopher M Dobson; S E Radford
Tertiary interactions in the folding pathway of hen lysozyme: kinetic studies using fluorescent probes.
Biochemistry 1994;33(17):5212-20.
1994: L J Smith; Christina Redfield; R A Smith; Christopher M Dobson; G M Clore; A M Gronenborn; M R Walter; T L Naganbushan; A Wlodawer
Comparison of four independently determined structures of human recombinant interleukin-4.
Nature structural biology 1994;1(5):301-10.
1994: Christina Redfield; Lorna J Smith; J Boyd; G M Lawrence; R G Edwards; C J Gershater; R A G Smith; Christopher M Dobson
Analysis of the solution structure of human interleukin-4 determined by heteronuclear three-dimensional nuclear magnetic resonance techniques.
Journal of molecular biology 1994;238(1):23-41.
1994: M Buck; S E Radford; Christopher M Dobson
Amide hydrogen exchange in a highly denatured state. Hen egg-white lysozyme in urea.
Journal of molecular biology 1994;237(3):247-54.
1994: U K Nowak; A Cooper; D Saunders; R A G Smith; Christopher M Dobson
Unfolding studies of the protease domain of urokinase-type plasminogen activator: the existence of partly folded states and stable subdomains.
Biochemistry 1994;33(10):2951-60.
1994: X Li; A M Bokman; Miguel Llinás; R A G Smith; Christopher M Dobson
Solution structure of the kringle domain from urokinase-type plasminogen activator.
Journal of molecular biology 1994;235(5):1548-59.
1994: Kevin J Lumb; J C Cheetham; Christopher M Dobson
1H nuclear magnetic resonance studies of hen lysozyme-N-acetylglucosamine oligosaccharide complexes in solution. Application of chemical shifts for the comparison of conformational changes in solution and in the crystal.
Journal of molecular biology 1994;235(3):1072-87.
1994: A T Alexandrescu; Y L Ng; Christopher M Dobson
Characterization of a trifluoroethanol-induced partially folded state of alpha-lactalbumin.
Journal of molecular biology 1994;235(2):587-99.
1994: Christopher M Dobson; P A Evans; S E Radford
Understanding how proteins fold: the lysozyme story so far.
Trends in biochemical sciences 1994;19(1):31-7.
1994: Christina Redfield; R A Smith; Christopher M Dobson
Structural characterization of a highly-ordered 'molten globule' at low pH.
Nature structural biology 1994;1(1):23-9.
1993: Herman Van Dael; Petra Haezebrouck; L Morozova; C Arico-Muendel; Christopher M Dobson
Partially folded states of equine lysozyme. Structural characterization and significance for protein folding.
Biochemistry 1993;32(44):11886-94.
1993: Andrew D Miranker; Carol V Robinson; S E Radford; R T Aplin; Christopher M Dobson
Detection of transient protein folding populations by mass spectrometry.
Science (New York, N.Y.) 1993;262(5135):896-900.
1993: A J Teuten; A Cooper; R A G Smith; Christopher M Dobson
Binding of a substrate analogue can induce co-operative structure in the plasmin serine-proteinase domain.
The Biochemical journal 1993;293 ( Pt 2)():567-72.
1993: A J Teuten; R W Broadhurst; R A G Smith; Christopher M Dobson
Characterization of structural and folding properties of streptokinase by n.m.r. spectroscopy.
The Biochemical journal 1993;290 ( Pt 2)():313-9.
1993: A T Alexandrescu; P A Evans; MC Pitkeathly; J Baum; Christopher M Dobson
Structure and dynamics of the acid-denatured molten globule state of alpha-lactalbumin: a two-dimensional NMR study.
Biochemistry 1993;32(7):1707-18.
1993: Lorna J Smith; M J Sutcliffe; Christina Redfield; Christopher M Dobson
Structure of hen lysozyme in solution.
Journal of molecular biology 1993;229(4):930-44.
1993: M Buck; S E Radford; Christopher M Dobson
A partially folded state of hen egg white lysozyme in trifluoroethanol: structural characterization and implications for protein folding.
Biochemistry 1993;32(2):669-78.
1993: U K Nowak; X Li; A J Teuten; R A G Smith; Christopher M Dobson
NMR studies of the dynamics of the multidomain protein urokinase-type plasminogen activator.
Biochemistry 1993;32(1):298-309.
1992: A T Alexandrescu; R W Broadhurst; C Wormald; C L Chyan; J Baum; Christopher M Dobson
1H-NMR assignments and local environments of aromatic residues in bovine, human and guinea pig variants of alpha-lactalbumin.
European journal of biochemistry / FEBS 1992;210(3):699-709.
1992: Daniel P Raleigh; P A Evans; MC Pitkeathly; Christopher M Dobson
A peptide model for proline isomerism in the unfolded state of staphylococcal nuclease.
Journal of molecular biology 1992;228(2):338-42.
1992: Christina Redfield; J Boyd; Lorna J Smith; R A G Smith; Christopher M Dobson
Loop mobility in a four-helix-bundle protein: 15N NMR relaxation measurements on human interleukin-4.
Biochemistry 1992;31(43):10431-7.
1992: X Li; R A G Smith; Christopher M Dobson
Sequential 1H NMR assignments and secondary structure of the kringle domain from urokinase.
Biochemistry 1992;31(40):9562-71.
1992: S E Radford; M Buck; K D Topping; Christopher M Dobson; P A Evans
Hydrogen exchange in native and denatured states of hen egg-white lysozyme.
Proteins 1992;14(2):237-48.
1992: Kevin J Lumb; Christopher M Dobson
1H nuclear magnetic resonance studies of the interaction of urea with hen lysozyme. Origins of the conformational change induced in hen lysozyme by N-acetylglucosamine oligosaccharides.
Journal of molecular biology 1992;227(1):9-14.
1992: S E Radford; Christopher M Dobson; P A Evans
The folding of hen lysozyme involves partially structured intermediates and multiple pathways.
Nature 1992;358(6384):302-7.
1992: A Cooper; S J Eyles; S E Radford; Christopher M Dobson
Thermodynamic consequences of the removal of a disulphide bridge from hen lysozyme.
Journal of molecular biology 1992;225(4):939-43.
1992: Lorna J Smith; Christina Redfield; J Boyd; G M Lawrence; R G Edwards; R A G Smith; Christopher M Dobson
Human interleukin 4. The solution structure of a four-helix bundle protein.
Journal of molecular biology 1992;224(4):899-904.
1992: X A Li; M J Sutcliffe; T W Schwartz; Christopher M Dobson
Sequence-specific 1H NMR assignments and solution structure of bovine pancreatic polypeptide.
Biochemistry 1992;31(4):1245-53.
1992: Kevin J Lumb; R T Aplin; S E Radford; David B Archer; David J Jeenes; N Lambert; Donald A MacKenzie; Christopher M Dobson; Gordon Lowe
A study of D52S hen lysozyme-GlcNAc oligosaccharide complexes by NMR spectroscopy and electrospray mass spectrometry.
FEBS letters 1992;296(2):153-7.
1991: Christina Redfield; Lorna J Smith; J Boyd; G M Lawrence; R G Edwards; R A G Smith; Christopher M Dobson
Secondary structure and topology of human interleukin 4 in solution.
Biochemistry 1991;30(46):11029-35.
1991: J C Cheetham; Daniel P Raleigh; R E Griest; Christina Redfield; Christopher M Dobson; Anthony R Rees
Antigen mobility in the combining site of an anti-peptide antibody.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(18):7968-72.
1991: Robert E Oswald; M J Sutcliffe; M Bamberger; R H Loring; E Braswell; Christopher M Dobson
Solution structure of neuronal bungarotoxin determined by two-dimensional NMR spectroscopy: sequence-specific assignments, secondary structure, and dimer formation.
Biochemistry 1991;30(20):4901-9.
1991: Andrew D Miranker; S E Radford; M Karplus; Christopher M Dobson
Demonstration by NMR of folding domains in lysozyme.
Nature 1991;349(6310):633-6.
1991: Lorna J Smith; M J Sutcliffe; Christina Redfield; Christopher M Dobson
Analysis of phi and chi 1 torsion angles for hen lysozyme in solution from 1H NMR spin-spin coupling constants.
Biochemistry 1991;30(4):986-96.
1991: R W Broadhurst; Christopher M Dobson; P J Hore; S E Radford; M L Rees
A photochemically induced dynamic nuclear polarization study of denatured states of lysozyme.
Biochemistry 1991;30(2):405-12.
1991: A J Teuten; R A G Smith; Christopher M Dobson
Domain interactions in human plasminogen studied by proton NMR.
FEBS letters 1991;278(1):17-22.
1991: S E Radford; D N Woolfson; S R Martin; Gordon Lowe; Christopher M Dobson
A three-disulphide derivative of hen lysozyme. Structure, dynamics and stability.
The Biochemical journal 1991;273(Pt 1)():211-7.
1991: M J Sutcliffe; Christopher M Dobson
Relaxation data in NMR structure determination: model calculations for the lysozyme-Gd3+ complex.
Proteins 1991;10(2):117-29.
1991: Christopher M Dobson
NMR spectroscopy and protein folding: studies of lysozyme and alpha-lactalbumin.
Ciba Foundation symposium 1991;161():167-81; discussion 181-9.
1991: P A Evans; K D Topping; Derek N Woolfson; Christopher M Dobson
Hydrophobic clustering in nonnative states of a protein: interpretation of chemical shifts in NMR spectra of denatured states of lysozyme.
Proteins 1991;9(4):248-66.
1990: Christina Redfield; Christopher M Dobson
1H NMR studies of human lysozyme: spectral assignment and comparison with hen lysozyme.
Biochemistry 1990;29(31):7201-14.
1990: David B Archer; David J Jeenes; Donald A MacKenzie; G Brightwell; N Lambert; Gordon Lowe; S E Radford; Christopher M Dobson
Hen egg white lysozyme expressed in, and secreted from, Aspergillus niger is correctly processed and folded.
Bio/technology (Nature Publishing Company) 1990;8(8):741-5.
1989: M J Bogusky; Christopher M Dobson; R A G Smith
Reversible independent unfolding of the domains of urokinase monitored by 1H NMR.
Biochemistry 1989;28(16):6728-35.
1989: R E Oswald; M J Bogusky; M Bamberger; R A Smith; Christopher M Dobson
Dynamics of the multidomain fibrinolytic protein urokinase from two-dimensional NMR.
Nature 1989;337(6207):579-82.
1989: J Baum; Christopher M Dobson; P A Evans; C Hanley
Characterization of a partly folded protein by NMR methods: studies on the molten globule state of guinea pig alpha-lactalbumin.
Biochemistry 1989;28(1):7-13.
1989: P A Evans; R A Kautz; Robert Fox; Christopher M Dobson
A magnetization-transfer nuclear magnetic resonance study of the folding of staphylococcal nuclease.
Biochemistry 1989;28(1):362-70.
1988: Christina Redfield; Christopher M Dobson
Sequential 1H NMR assignments and secondary structure of hen egg white lysozyme in solution.
Biochemistry 1988;27(1):122-36.
1987: Christopher M Dobson; L Y Lian
A 31P MAS NMR study of cytidine 2'-phosphate bound to ribonuclease A in the crystalline state.
FEBS letters 1987;225(1-2):183-7.
1987: P A Evans; Christopher M Dobson; R A Kautz; G Hatfull; Robert Fox
Proline isomerism in staphylococcal nuclease characterized by NMR and site-directed mutagenesis.
Nature 1987;329(6136):266-8.
1986: C B Post; Bernard Brooks; M Karplus; Christopher M Dobson; P J Artymiuk; J C Cheetham; D C Phillips
Molecular dynamics simulations of native and substrate-bound lysozyme. A study of the average structures and atomic fluctuations.
Journal of molecular biology 1986;190(3):455-79.
1986: Robert Fox; P A Evans; Christopher M Dobson
Multiple conformations of a protein demonstrated by magnetization transfer NMR spectroscopy.
Nature 1986;320(6058):192-4.
1985: C Redfield; Christopher M Dobson; Ruud M Scheek; S Stob; R Kaptein
Surface accessibility of aromatic residues in human lysozyme using photochemically induced dynamic nuclear polarization NMR spectroscopy.
FEBS letters 1985;185(2):248-52.
1985: James W Fett; D J Strydom; R R Lobb; E M Alderman; B L Vallee; P J Artymiuk; S Collett; D C Phillips; Christopher M Dobson; C Redfield
Lysozyme: a major secretory product of a human colon carcinoma cell line.
Biochemistry 1985;24(4):965-75.