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Roberto Docampo

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Silvia N J Moreno; Roberto Docampo
Polyphosphate and its diverse functions in host cells and pathogens.
Marion Recher; Sergio H Szajnman; Alejandro P Barboza; Roberto Docampo; Mariana Ferrer-Casal; Melina Galizzi; Zhu-Hong Li; Silvia N J Moreno; Juan B Rodriguez
Design, synthesis and biological evaluation of sulfur-containing 1,1-bisphosphonic acids as antiparasitic agents.
Guozhong Huang; Silvia N J Moreno; Andrew P Thomas; Paula J Bartlett; Roberto Docampo
Acidocalcisomes of Trypanosoma brucei have an inositol 1,4,5-trisphosphate receptor that is required for growth and infectivity.

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All Publications

2013: Silvia N J Moreno; Roberto Docampo
Polyphosphate and its diverse functions in host cells and pathogens.
PLoS pathogens 2013;9(5):e1003230.
2013: Marion Recher; Sergio H Szajnman; Alejandro P Barboza; Roberto Docampo; Mariana Ferrer-Casal; Melina Galizzi; Zhu-Hong Li; Silvia N J Moreno; Juan B Rodriguez
Design, synthesis and biological evaluation of sulfur-containing 1,1-bisphosphonic acids as antiparasitic agents.
European journal of medicinal chemistry 2013;60():431-40.
2013: Guozhong Huang; Silvia N J Moreno; Andrew P Thomas; Paula J Bartlett; Roberto Docampo
Acidocalcisomes of Trypanosoma brucei have an inositol 1,4,5-trisphosphate receptor that is required for growth and infectivity.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(5):1887-92.
2013: Roberto Docampo
Redesign of the articles that now have a more modern look.
The Journal of eukaryotic microbiology 2013;60(1):1.
2012: David Moreno-Sanchez; Felix A Ruiz; Laura Hernandez-Ruiz; Roberto Docampo
Polyphosphate is a novel pro-inflammatory regulator of mast cells and is located in acidocalcisomes.
The Journal of biological chemistry 2012;287(34):28435-44.
2012: Srinivas Aripirala; Roberto Docampo; Sandra B. Gabelli; Jean Jakoncic; Juan B Rodriguez; Sergio H Szajnman; Mario Amzel
Design, synthesis, calorimetry, and crystallographic analysis of 2-alkylaminoethyl-1,1-bisphosphonates as inhibitors of Trypanosoma cruzi farnesyl diphosphate synthase.
Journal of medicinal chemistry 2012;55(14):6445-54.
2012: Bruno Demoro; Roberto Docampo; Ricardo Faccio; Melina Galizzi; Dinorah Gambino; Mercedes González; Leena Malayil; Alvaro W Mombrú; Diego Benítez; Francesco Caruso; Hugo Cerecetto; Miriam Rossi; Lucía Otero
Bisphosphonate metal complexes as selective inhibitors of Trypanosoma cruzi farnesyl diphosphate synthase.
Dalton transactions (Cambridge, England : 2003) 2012;41(21):6468-76.
2012: Zhu-Hong Li; Nicolás Mendiondo; Haiming Wang; Vanina E Alvarez; Javier G De Gaudenzi; Alberto C Frasch; Jessica Kissinger; Roberto Docampo
A 43-nucleotide U-rich element in 3'-untranslated region of large number of Trypanosoma cruzi transcripts is important for mRNA abundance in intracellular amastigotes.
The Journal of biological chemistry 2012;287(23):19058-69.
2012: Timothy E Long; Xiao Lu; Roberto Docampo; Melina Galizzi; Jiri Gut; Philip J Rosenthal
Phosphonium lipocations as antiparasitic agents.
Bioorganic & medicinal chemistry letters 2012;22(8):2976-9.
2012: Sergio H Szajnman; Valeria S Rosso; Alyssa Smith; Roberto Docampo; Leena Malayil; Silvia N J Moreno; Juan B Rodriguez
1-(Fluoroalkylidene)-1,1-bisphosphonic acids are potent and selective inhibitors of the enzymatic activity of Toxoplasma gondii farnesyl pyrophosphate synthase.
Organic & biomolecular chemistry 2012;10(7):1424-33.
2012: Veronica Jimenez; Roberto Docampo
Molecular and electrophysiological characterization of a novel cation channel of Trypanosoma cruzi.
PLoS pathogens 2012;8(6):e1002750.
2012: Roberto Docampo; Julius Lukeš
Trypanosomes and the solution to a 50-year mitochondrial calcium mystery.
Trends in parasitology 2012;28(1):31-7.
2011: Zhu-Hong Li; Juan J Cazzulo; Javier G De Gaudenzi; Celso Sant'Anna; Vanina E Alvarez; Alberto C C Frasch; Roberto Docampo
Hyperosmotic stress induces aquaporin-dependent cell shrinkage, polyphosphate synthesis, amino acid accumulation, and global gene expression changes in Trypanosoma cruzi.
The Journal of biological chemistry 2011;286(51):43959-71.
2011: Guozhong Huang; Zhu-Hong Li; Peter Rohloff; Celso Sant'Anna; Dianne L Wellems; Jianmin Fang; Roberto Docampo
Adaptor protein-3 (AP-3) complex mediates the biogenesis of acidocalcisomes and is essential for growth and virulence of Trypanosoma brucei.
The Journal of biological chemistry 2011;286(42):36619-30.
2011: Lia Carolina Soares Medeiros; Silvia Moreno; Helmut Plattner; Sergio H Seabra; Hector Barrabin; Renato A DaMatta; Wanderley de Souza; Roberto Docampo; Fabio Gomes; Joachim Hentschel; Urara Kawazoe; Luis Renato Maia Maciel; Kildare Miranda
Volutin granules of Eimeria parasites are acidic compartments and have physiological and structural characteristics similar to acidocalcisomes.
The Journal of eukaryotic microbiology 2011;58(5):416-23.
2011: Roberto Docampo; Silvia N J Moreno
Acidocalcisomes.
Cell calcium 2011;50(2):113-9.
2011: Valeria S Rosso; Sergio H Szajnman; Leena Malayil; Melina Galizzi; Silvia N J Moreno; Roberto Docampo; Juan B Rodriguez
Synthesis and biological evaluation of new 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase.
Bioorganic & medicinal chemistry 2011;19(7):2211-7.
2011: Rosa M de Lederkremer; Rosalía Agusti; Roberto Docampo
Inositolphosphoceramide metabolism in Trypanosoma cruzi as compared with other trypanosomatids.
The Journal of eukaryotic microbiology 2011;58(2):79-87.
2011: Isabela Ramos; Katsuharu Saito; Wanderley de Souza; Roberto Docampo; Fabio Gomes; Norton Heise; Carolina M Koeller; Ednildo A Machado; Hatisaburo Masuda; Kildare Miranda
Acidocalcisomes as calcium- and polyphosphate-storage compartments during embryogenesis of the insect Rhodnius prolixus Stahl.
PloS one 2011;6(11):e27276.
2011: Roberto Docampo
Molecular parasitology in the 21st century.
Essays in biochemistry 2011;51():1-13.
2011: Roberto Docampo; Veronica Jimenez; Sharon King-Keller; Zhu-hong Li; Silvia N J Moreno
The role of acidocalcisomes in the stress response of Trypanosoma cruzi.
Advances in parasitology 2011;75():307-24.
2011: Paul N Ulrich; Veronica Jimenez; Miyoung Park; Vicente P Martins; James Atwood; Kristen Moles; Dalis Collins; Peter Rohloff; Rick L Tarleton; Silvia N J Moreno; Ronald C Orlando; Roberto Docampo
Identification of contractile vacuole proteins in Trypanosoma cruzi.
PloS one 2011;6(3):e18013.
2011: Alejandra C Schoijet; Kildare Miranda; Lia Carolina Soares Medeiros; Wanderley de Souza; Mirtha M Flawiá; Héctor N Torres; Omar P Pignataro; Roberto Docampo; Guillermo Alonso
Defining the role of a FYVE domain in the localization and activity of a cAMP phosphodiesterase implicated in osmoregulation in Trypanosoma cruzi.
Molecular microbiology 2011;79(1):50-62.
2010: Bruno Demoro; Francesco Caruso; Miriam Rossi; Diego Benítez; Mercedes Gonzalez; Hugo Cerecetto; Beatriz Parajón-Costa; Jorge Castiglioni; Melina Galizzi; Roberto Docampo; Lucía Otero; Dinorah Gambino
Risedronate metal complexes potentially active against Chagas disease.
Journal of inorganic biochemistry 2010;104(12):1252-8.
2010: Vicente de Paulo Martins; Michael Okura; Danijela Maric; David M Engman; Mauricio Vieira; Roberto Docampo; Silvia N J Moreno
Acylation-dependent export of Trypanosoma cruzi phosphoinositide-specific phospholipase C to the outer surface of amastigotes.
The Journal of biological chemistry 2010;285(40):30906-17.
2010: Vicente de Paulo Martins; Melina Galizzi; Maria Laura Salto; Roberto Docampo; Silvia N J Moreno
Developmental expression of a Trypanosoma cruzi phosphoinositide-specific phospholipase C in amastigotes and stimulation of host phosphoinositide hydrolysis.
Infection and immunity 2010;78(10):4206-12.
2010: Sharon King-Keller; Minyong Li; Alyssa Smith; Shilong Zheng; Gurpreet Kaur; Xiaochuan Yang; Binghe Wang; Roberto Docampo
Chemical validation of phosphodiesterase C as a chemotherapeutic target in Trypanosoma cruzi, the etiological agent of Chagas' disease.
Antimicrobial agents and chemotherapy 2010;54(9):3738-45.
2010: Isabela B Ramos; Kildare Miranda; Douglas A Pace; Katherine C Verbist; Fu-Yang Lin; Yonghui Zhang; Eric Oldfield; Ednildo A Machado; Wanderley de Souza; Roberto Docampo
Calcium- and polyphosphate-containing acidic granules of sea urchin eggs are similar to acidocalcisomes, but are not the targets for NAADP.
The Biochemical journal 2010;429(3):485-95.
2010: Teresa Cristina Leandro de Jesus; Renata Rosito Tonelli; Sheila C Nardelli; Leonardo da Silva Augusto; Maria Cristina M Motta; Wendell Girard-Dias; Kildare Miranda; Paul Ulrich; Veronica Jimenez; Antonio Barquilla; Miguel Navarro; Roberto Docampo; Sergio Schenkman
Target of rapamycin (TOR)-like 1 kinase is involved in the control of polyphosphate levels and acidocalcisome maintenance in Trypanosoma brucei.
The Journal of biological chemistry 2010;285(31):24131-40.
2010: Agam Prasad Singh; Yonghui Zhang; Joo-Hwan No; Roberto Docampo; Victor Nussenzweig; Eric Oldfield
Lipophilic bisphosphonates are potent inhibitors of Plasmodium liver-stage growth.
Antimicrobial agents and chemotherapy 2010;54(7):2987-93.
2010: Isabela B Ramos; Kildare Miranda; Paul Ulrich; Peter Ingram; Ann Lefurgey; Ednildo A Machado; Wanderley de Souza; Roberto Docampo
Calcium- and polyphosphate-containing acidocalcisomes in chicken egg yolk.
Biology of the cell / under the auspices of the European Cell Biology Organization 2010;102(7):421-34.
2010: Sandip Patel; Roberto Docampo
Acidic calcium stores open for business: expanding the potential for intracellular Ca2+ signaling.
Trends in cell biology 2010;20(5):277-86.
2010: Roberto Docampo; Paul Ulrich; Silvia N J Moreno
Evolution of acidocalcisomes and their role in polyphosphate storage and osmoregulation in eukaryotic microbes.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2010;365(1541):775-84.
2010: Noelia Lander; Carolina Bernal; Nardy Diez; Nestor Anez; Roberto Docampo; José Luis Ramírez
Localization and developmental regulation of a dispersed gene family 1 protein in Trypanosoma cruzi.
Infection and immunity 2010;78(1):231-40.
2009: Roman Mezencev; Melina Galizzi; Peter Kutschy; Roberto Docampo
Trypanosoma cruzi: antiproliferative effect of indole phytoalexins on intracellular amastigotes in vitro.
Experimental parasitology 2009;122(1):66-9.
2009: Silvia N J Moreno; Roberto Docampo
The role of acidocalcisomes in parasitic protists.
The Journal of eukaryotic microbiology 2009;56(3):208-13.
2009: Lucimar S Motta; Isabela B Ramos; Fabio Gomes; Wanderley de Souza; Donald E Champagne; Marcelo F Santiago; Roberto Docampo; Kildare Miranda; Ednildo A Machado
Proton-pyrophosphatase and polyphosphate in acidocalcisome-like vesicles from oocytes and eggs of Periplaneta americana.
Insect biochemistry and molecular biology 2009;39(3):198-206.
2009: Sandip Patel; Roberto Docampo
In with the TRP channels: intracellular functions for TRPM1 and TRPM2.
Science signaling 2009;2(95):pe69.
2008: Alejandra C Schoijet; Kildare Miranda; Wendell Girard-Dias; Wanderley de Souza; Mirtha M Flawiá; Héctor N Torres; Roberto Docampo; Guillermo Alonso
A Trypanosoma cruzi phosphatidylinositol 3-kinase (TcVps34) is involved in osmoregulation and receptor-mediated endocytosis.
The Journal of biological chemistry 2008;283(46):31541-50.
2008: Marcela Ferella; Daniel Nilsson; Hamid Darban; Claudia Rodrigues; Esteban J Bontempi; Roberto Docampo; Björn Andersson
Proteomics in Trypanosoma cruzi--localization of novel proteins to various organelles.
Proteomics 2008;8(13):2735-49.
2008: Marcela Ferella; Zhu-Hong Li; Björn Andersson; Roberto Docampo
Farnesyl diphosphate synthase localizes to the cytoplasm of Trypanosoma cruzi and T. brucei.
Experimental parasitology 2008;119(2):308-12.
2008: Maria Laura Salto; Theresa Kuhlenschmidt; Mark S Kuhlenschmidt; Rosa M de Lederkremer; Roberto Docampo
Phospholipid and glycolipid composition of acidocalcisomes of Trypanosoma cruzi.
Molecular and biochemical parasitology 2008;158(2):120-30.
2008: Sergio H Szajnman; Guadalupe E García Liñares; Zhu-Hong Li; Cuiying Jiang; Melina Galizzi; Esteban J Bontempi; Marcela Ferella; Silvia N J Moreno; Roberto Docampo; Juan B Rodriguez
Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase.
Bioorganic & medicinal chemistry 2008;16(6):3283-90.
2008: Roberto Docampo; Silvia N J Moreno
The acidocalcisome as a target for chemotherapeutic agents in protozoan parasites.
Current pharmaceutical design 2008;14(9):882-8.
2008: Roberto Docampo
Special section on novel organelles in parasitic protozoa.
Experimental parasitology 2008;118(1):1.
2008: Peter Rohloff; Roberto Docampo
A contractile vacuole complex is involved in osmoregulation in Trypanosoma cruzi.
Experimental parasitology 2008;118(1):17-24.
2007: Jianmin Fang; Felix A Ruiz; Melissa Docampo; Shuhong Luo; Juliany C F Rodrigues; Lucimar S Motta; Peter Rohloff; Roberto Docampo
Overexpression of a Zn2+-sensitive soluble exopolyphosphatase from Trypanosoma cruzi depletes polyphosphate and affects osmoregulation.
The Journal of biological chemistry 2007;282(44):32501-10.
2007: Jianmin Fang; Peter Rohloff; Kildare Miranda; Roberto Docampo
Ablation of a small transmembrane protein of Trypanosoma brucei (TbVTC1) involved in the synthesis of polyphosphate alters acidocalcisome biogenesis and function, and leads to a cytokinesis defect.
The Biochemical journal 2007;407(2):161-70.
2007: Guadalupe García Liñares; Santiago Gismondi; Nicolás Osa Codesido; Silvia N J Moreno; Roberto Docampo; Juan B Rodriguez
Fluorine-containing aryloxyethyl thiocyanate derivatives are potent inhibitors of Trypanosoma cruzi and Toxoplasma gondii proliferation.
Bioorganic & medicinal chemistry letters 2007;17(18):5068-71.
2006: Marcela Ferella; Andrea Montalvetti; Peter Rohloff; Kildare Miranda; Jianmin Fang; Silvia Reina; Makoto Kawamukai; Jacqueline Búa; Daniel Nilsson; Carlos Pravia; Alejandro M Katzin; Maria Cassera; Lena Aslund; Björn Andersson; Roberto Docampo; Esteban J Bontempi
A solanesyl-diphosphate synthase localizes in glycosomes of Trypanosoma cruzi.
The Journal of biological chemistry 2006;281(51):39339-48.
2006: Peter Rohloff; Roberto Docampo
Ammonium production during hypo-osmotic stress leads to alkalinization of acidocalcisomes and cytosolic acidification in Trypanosoma cruzi.
Molecular and biochemical parasitology 2006;150(2):249-55.
2006: Shuhong Luo; Jianmin Fang; Roberto Docampo
Molecular characterization of Trypanosoma brucei P-type H+-ATPases.
The Journal of biological chemistry 2006;281(31):21963-73.
2006: Ann Stephanie Smith; Nicola J Mutch; Deepak Baskar; Peter Rohloff; Roberto Docampo; James Morrissey
Polyphosphate modulates blood coagulation and fibrinolysis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(4):903-8.
2006: Esteban L Ravaschino; Roberto Docampo; Juan B Rodriguez
Design, synthesis, and biological evaluation of phosphinopeptides against Trypanosoma cruzi targeting trypanothione biosynthesis.
Journal of medicinal chemistry 2006;49(1):426-35.
2006: Sandra B. Gabelli; Jason S McLellan; Andrea Montalvetti; Eric Oldfield; Roberto Docampo; Mario Amzel
Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: implications for drug design.
Proteins 2006;62(1):80-8.
2005: Mauricio Vieira; Peter Rohloff; Shuhong Luo; Narcisa L Cunha-e-Silva; Wanderley de Souza; Roberto Docampo
Role for a P-type H+-ATPase in the acidification of the endocytic pathway of Trypanosoma cruzi.
The Biochemical journal 2005;392(Pt 3):467-74.
2005: Norma Marchesini; Mauricio Vieira; Shuhong Luo; Silvia N J Moreno; Roberto Docampo
A malaria parasite-encoded vacuolar H(+)-ATPase is targeted to the host erythrocyte.
The Journal of biological chemistry 2005;280(44):36841-7.
2005: Sergio H Szajnman; Esteban L Ravaschino; Roberto Docampo; Juan B Rodriguez
Synthesis and biological evaluation of 1-amino-1,1-bisphosphonates derived from fatty acids against Trypanosoma cruzi targeting farnesyl pyrophosphate synthase.
Bioorganic & medicinal chemistry letters 2005;15(21):4685-90.
2005: Evangelia Kotsikorou; Yongcheng Song; Julian M W Chan; Stephanie Faelens; Zev Tovian; Erin Broderick; Norbert Bakalara; Roberto Docampo; Eric Oldfield
Bisphosphonate inhibition of the exopolyphosphatase activity of the Trypanosoma brucei soluble vacuolar pyrophosphatase.
Journal of medicinal chemistry 2005;48(19):6128-39.
2005: Ileana C Cuevas; Peter Rohloff; Daniel O Sánchez; Roberto Docampo
Characterization of farnesylated protein tyrosine phosphatase TcPRL-1 from Trypanosoma cruzi.
Eukaryotic cell 2005;4(9):1550-61.
2005: Michael Okura; Jianmin Fang; Maria Laura Salto; Randall S Singer; Roberto Docampo; Silvia N J Moreno
A lipid-modified phosphoinositide-specific phospholipase C (TcPI-PLC) is involved in differentiation of trypomastigotes to amastigotes of Trypanosoma cruzi.
The Journal of biological chemistry 2005;280(16):16235-43.
2005: Roberto Docampo; Wanderley de Souza; Kildare Miranda; Peter Rohloff; Silvia N J Moreno
Acidocalcisomes - conserved from bacteria to man.
Nature reviews. Microbiology 2005;3(3):251-61.
2005: Kai Zhang; Fong-Fu Hsu; David A Scott; Roberto Docampo; John Turk; Stephen M Beverley
Leishmania salvage and remodelling of host sphingolipids in amastigote survival and acidocalcisome biogenesis.
Molecular microbiology 2005;55(5):1566-78.
2005: Kildare Miranda; Anibal E Vercesi; Rosana Catisti; Wanderley de Souza; Claudia Rodrigues; Roberto Docampo
P-type proton ATPases are involved in intracellular calcium and proton uptake in the plant parasite Phytomonas francai.
The Journal of eukaryotic microbiology 2005;52(1):55-60.
2004: Peter Rohloff; Andrea Montalvetti; Roberto Docampo
Acidocalcisomes and the contractile vacuole complex are involved in osmoregulation in Trypanosoma cruzi.
The Journal of biological chemistry 2004;279(50):52270-81.
2004: Manfredo Seufferheld; Christopher R Lea; Mauricio Vieira; Eric Oldfield; Roberto Docampo
The H(+)-pyrophosphatase of Rhodospirillum rubrum is predominantly located in polyphosphate-rich acidocalcisomes.
The Journal of biological chemistry 2004;279(49):51193-202.
2004: Kildare Miranda; Roberto Docampo; Orlando Grillo; Wanderley de Souza
Acidocalcisomes of trypanosomatids have species-specific elemental composition.
Protist 2004;155(4):395-405.
2004: Felix A Ruiz; Christopher R Lea; Eric Oldfield; Roberto Docampo
Human platelet dense granules contain polyphosphate and are similar to acidocalcisomes of bacteria and unicellular eukaryotes.
The Journal of biological chemistry 2004;279(43):44250-7.
2004: Kildare Miranda; Claudia Rodrigues; Joachim Hentchel; Anibal E Vercesi; Helmut Plattner; Wanderley de Souza; Roberto Docampo
Acidocalcisomes of Phytomonas françai possess distinct morphological characteristics and contain iron.
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2004;10(5):647-55.
2004: Felix A Ruiz; Shuhong Luo; Silvia N J Moreno; Roberto Docampo
Polyphosphate content and fine structure of acidocalcisomes of Plasmodium falciparum.
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2004;10(5):563-7.
2004: Roberto Docampo
Introduction: A special issue on cellular biology of protozoan parasites.
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2004;10(5):511-2.
2004: Junhong Mao; Yi-Gui Gao; Sarah Odeh; Howard Robinson; Andrea Montalvetti; Roberto Docampo; Eric Oldfield
Crystallization and preliminary X-ray diffraction study of the farnesyl diphosphate synthase from Trypanosoma brucei.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 10):1863-6.
2004: Andrea Montalvetti; Peter Rohloff; Roberto Docampo
A functional aquaporin co-localizes with the vacuolar proton pyrophosphatase to acidocalcisomes and the contractile vacuole complex of Trypanosoma cruzi.
The Journal of biological chemistry 2004;279(37):38673-82.
2004: Kildare Miranda; Roberto Docampo; Orlando Grillo; Anderson Franzen; Marcia Attias; Anibal E Vercesi; Helmut Plattner; Joachim Hentschel; Wanderley de Souza
Dynamics of polymorphism of acidocalcisomes in Leishmania parasites.
Histochemistry and cell biology 2004;121(5):407-18.
2004: Shuhong Luo; Peter Rohloff; Joanna Cox; Sergio A Uyemura; Roberto Docampo
Trypanosoma brucei plasma membrane-type Ca(2+)-ATPase 1 (TbPMC1) and 2 (TbPMC2) genes encode functional Ca(2+)-ATPases localized to the acidocalcisomes and plasma membrane, and essential for Ca(2+) homeostasis and growth.
The Journal of biological chemistry 2004;279(14):14427-39.
2004: Luciana R Garzoni; Mariana C Waghabi; Marcos M Baptista; Solange L de Castro; Maria de Nazareth L Meirelles; Constança Britto; Roberto Docampo; Eric Oldfield; Julio A Urbina
Antiparasitic activity of risedronate in a murine model of acute Chagas' disease.
International journal of antimicrobial agents 2004;23(3):286-90.
2004: Luciana R Garzoni; Aura Caldera; Maria de Nazareth L Meirelles; Solange L de Castro; Roberto Docampo; Gary A Meints; Eric Oldfield; Julio A Urbina
Selective in vitro effects of the farnesyl pyrophosphate synthase inhibitor risedronate on Trypanosoma cruzi.
International journal of antimicrobial agents 2004;23(3):273-85.
2004: Guillaume Lemercier; Benoît Espiau; Felix A Ruiz; Mauricio Vieira; Shuhong Luo; Théo Baltz; Roberto Docampo; Norbert Bakalara
A pyrophosphatase regulating polyphosphate metabolism in acidocalcisomes is essential for Trypanosoma brucei virulence in mice.
The Journal of biological chemistry 2004;279(5):3420-5.
2004: Sergio A Uyemura; Shuhong Luo; Mauricio Vieira; Silvia N J Moreno; Roberto Docampo
Oxidative phosphorylation and rotenone-insensitive malate- and NADH-quinone oxidoreductases in Plasmodium yoelii yoelii mitochondria in situ.
The Journal of biological chemistry 2004;279(1):385-93.
2003: Julio A Urbina; Roberto Docampo
Specific chemotherapy of Chagas disease: controversies and advances.
Trends in parasitology 2003;19(11):495-501.
2003: Sergio H Szajnman; Andrea Montalvetti; Youhong Wang; Roberto Docampo; Juan B Rodriguez
Bisphosphonates derived from fatty acids are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase.
Bioorganic & medicinal chemistry letters 2003;13(19):3231-5.
2003: Ianina Conte; Carlos Labriola; Juan J Cazzulo; Roberto Docampo; Armando J Parodi
The interplay between folding-facilitating mechanisms in Trypanosoma cruzi endoplasmic reticulum.
Molecular biology of the cell 2003;14(9):3529-40.
2003: Manfredo Seufferheld; Mauricio C F Vieira; Felix A Ruiz; Claudia Rodrigues; Silvia N J Moreno; Roberto Docampo
Identification of organelles in bacteria similar to acidocalcisomes of unicellular eukaryotes.
The Journal of biological chemistry 2003;278(32):29971-8.
2003: Roberto Docampo
New and reemerging infectious diseases.
Emerging infectious diseases 2003;9(8):1030-3.
2003: Silvia N J Moreno; Roberto Docampo
Calcium regulation in protozoan parasites.
Current opinion in microbiology 2003;6(4):359-64.
2003: Maria Laura Salto; Laura E Bertello; Mauricio Vieira; Roberto Docampo; Silvia N J Moreno; Rosa M de Lederkremer
Formation and remodeling of inositolphosphoceramide during differentiation of Trypanosoma cruzi from trypomastigote to amastigote.
Eukaryotic cell 2003;2(4):756-68.
2003: Roberto Docampo; Silvia N J Moreno
Current chemotherapy of human African trypanosomiasis.
Parasitology research 2003;90 Supp 1():S10-3.
2003: Julio A Urbina; Juan Luis Concepcion; Andrea Montalvetti; Juan B Rodriguez; Roberto Docampo
Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease.
Antimicrobial agents and chemotherapy 2003;47(6):2047-50.
2003: Andrea Montalvetti; Alexis Fernandez; John M Sanders; Subhash Ghosh; Erin M Van Brussel; Eric Oldfield; Roberto Docampo
Farnesyl pyrophosphate synthase is an essential enzyme in Trypanosoma brucei. In vitro RNA interference and in vivo inhibition studies.
The Journal of biological chemistry 2003;278(19):17075-83.
2003: Peter Rohloff; Claudia Rodrigues; Roberto Docampo
Regulatory volume decrease in Trypanosoma cruzi involves amino acid efflux and changes in intracellular calcium.
Molecular and biochemical parasitology 2003;126(2):219-30.
2002: Claudia Rodrigues; Felix A Ruiz; Mauricio Vieira; Janet E Hill; Roberto Docampo
An acidocalcisomal exopolyphosphatase from Leishmania major with high affinity for short chain polyphosphate.
The Journal of biological chemistry 2002;277(52):50899-906.
2002: Shuhong Luo; David A Scott; Roberto Docampo
Trypanosoma cruzi H+-ATPase 1 (TcHA1) and 2 (TcHA2) genes complement yeast mutants defective in H+ pumps and encode plasma membrane P-type H+-ATPases with different enzymatic properties.
The Journal of biological chemistry 2002;277(46):44497-506.
2002: Guillaume Lemercier; Sandrine Dutoya; Shuhong Luo; Felix A Ruiz; Claudia Rodrigues; Théo Baltz; Roberto Docampo; Norbert Bakalara
A vacuolar-type H+-pyrophosphatase governs maintenance of functional acidocalcisomes and growth of the insect and mammalian forms of Trypanosoma brucei.
The Journal of biological chemistry 2002;277(40):37369-76.
2002: Nicole Van Der Heyden; Roberto Docampo
Significant differences between procyclic and bloodstream forms of Trypanosoma brucei in the maintenance of their plasma membrane potential.
The Journal of eukaryotic microbiology 2002;49(5):407-13.
2002: Roberto Docampo
Fifth annual conference on new and re-emerging infectious diseases.
Emerging infectious diseases 2002;8(9):1008-10.
2002: Eleonora Elhalem; Brian N Bailey; Roberto Docampo; István Ujváry; Sergio H Szajnman; Juan B Rodriguez
Design, synthesis, and biological evaluation of aryloxyethyl thiocyanate derivatives against Trypanosoma cruzi.
Journal of medicinal chemistry 2002;45(18):3984-99.
2002: Roberto Docampo
New and re-emerging infectious diseases.
Trends in parasitology 2002;18(8):334-6.
2002: Benjamin Moreno; Claudia Rodrigues; Brian N Bailey; Julio A Urbina; Silvia N J Moreno; Roberto Docampo; Eric Oldfield
Magic-angle spinning (31)P NMR spectroscopy of condensed phosphates in parasitic protozoa: visualizing the invisible.
FEBS letters 2002;523(1-3):207-12.
2002: Noris Rodriguez; Brian N Bailey; Michael B Martin; Eric Oldfield; Julio A Urbina; Roberto Docampo
Radical cure of experimental cutaneous leishmaniasis by the bisphosphonate pamidronate.
The Journal of infectious diseases 2002;186(1):138-40.
2002: Rosa Martinez; Youhong Wang; Gustavo Benaim; Marlene Benchimol; Wanderley de Souza; David A Scott; Roberto Docampo
A proton pumping pyrophosphatase in the Golgi apparatus and plasma membrane vesicles of Trypanosoma cruzi.
Molecular and biochemical parasitology 2002;120(2):205-13.
2002: Norma Marchesini; Felix A Ruiz; Mauricio Vieira; Roberto Docampo
Acidocalcisomes are functionally linked to the contractile vacuole of Dictyostelium discoideum.
The Journal of biological chemistry 2002;277(10):8146-53.
2002: Vanessa Yardley; Anis A Khan; Michael B Martin; Teri Slifer; Fausto G Araujo; Silvia N J Moreno; Roberto Docampo; Simon L Croft; Eric Oldfield
In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii.
Antimicrobial agents and chemotherapy 2002;46(3):929-31.
2002: Nicole Van Der Heyden; Roberto Docampo
Proton and sodium pumps regulate the plasma membrane potential of different stages of Trypanosoma cruzi.
Molecular and biochemical parasitology 2002;120(1):127-39.
2002: Noris M Rodriguez; Roberto Docampo; Hong-gang Lu Hg; David A Scott
Overexpression of the Leishmania amazonensis Ca2+-ATPase gene lmaa1 enhances virulence.
Cellular microbiology 2002;4(2):117-26.
2002: Norma Marchesini; Roberto Docampo
A plasma membrane P-type H(+)-ATPase regulates intracellular pH in Leishmania mexicana amazonensis.
Molecular and biochemical parasitology 2002;119(2):225-36.
2002: Maria Laura Salto; Tetsuya Furuya; Silvia N J Moreno; Roberto Docampo; Rosa M de Lederkremer
The phosphatidylinositol-phospholipase C from Trypanosoma cruzi is active on inositolphosphoceramide.
Molecular and biochemical parasitology 2002;119(1):131-3.
2001: Felix A Ruiz; Norma Marchesini; Manfredo Seufferheld; Roberto Docampo
The polyphosphate bodies of Chlamydomonas reinhardtii possess a proton-pumping pyrophosphatase and are similar to acidocalcisomes.
The Journal of biological chemistry 2001;276(49):46196-203.
2001: Andrea Montalvetti; Brian N Bailey; Michael B Martin; G W Severin; Eric Oldfield; Roberto Docampo
Bisphosphonates are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase.
The Journal of biological chemistry 2001;276(36):33930-7.
2001: Claudia Rodrigues; Rosana Catisti; Sergio A Uyemura; Anibal E Vercesi; Renee Lira; C Rodriguez; Julio A Urbina; Roberto Docampo
The sterol composition of Trypanosoma cruzi changes after growth in different culture media and results in different sensitivity to digitonin-permeabilization.
The Journal of eukaryotic microbiology 2001;48(5):588-94.
2001: T Furuya; M Okura; Felix A Ruiz; David A Scott; Roberto Docampo
TcSCA complements yeast mutants defective in Ca2+ pumps and encodes a Ca2+-ATPase that localizes to the endoplasmic reticulum of Trypanosoma cruzi.
The Journal of biological chemistry 2001;276(35):32437-45.
2001: Roberto Docampo
Recent developments in the chemotherapy of Chagas disease.
Current pharmaceutical design 2001;7(12):1157-64.
2001: Felix A Ruiz; Claudia Rodrigues; Roberto Docampo
Rapid changes in polyphosphate content within acidocalcisomes in response to cell growth, differentiation, and environmental stress in Trypanosoma cruzi.
The Journal of biological chemistry 2001;276(28):26114-21.
2001: Benjamin Moreno; Brian N Bailey; Shuhong Luo; Michael B Martin; Mark S Kuhlenschmidt; Silvia N J Moreno; Roberto Docampo; Eric Oldfield
(31)P NMR of apicomplexans and the effects of risedronate on Cryptosporidium parvum growth.
Biochemical and biophysical research communications 2001;284(3):632-7.
2001: Roberto Docampo; Silvia N J Moreno
Bisphosphonates as chemotherapeutic agents against trypanosomatid and apicomplexan parasites.
Current drug targets. Infectious disorders 2001;1(1):51-61.
2001: Roberto Docampo; Silvia N J Moreno
The acidocalcisome.
Molecular and biochemical parasitology 2001;114(2):151-9.
2001: Sergio H Szajnman; Brian N Bailey; Roberto Docampo; Juan B Rodriguez
Bisphosphonates derived from fatty acids are potent growth inhibitors of Trypanosoma cruzi.
Bioorganic & medicinal chemistry letters 2001;11(6):789-92.
2001: Michael B Martin; Joshua S Grimley; Jared C Lewis; H T Heath; Brian N Bailey; Howard Kendrick; Vanessa Yardley; Aura Caldera; Renee Lira; Julio A Urbina; Silvia N J Moreno; Roberto Docampo; Simon L Croft; Eric Oldfield
Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy.
Journal of medicinal chemistry 2001;44(6):909-16.
2000: J E Hill; David A Scott; Shuhong Luo; Roberto Docampo
Cloning and functional expression of a gene encoding a vacuolar-type proton-translocating pyrophosphatase from Trypanosoma cruzi.
The Biochemical journal 2000;351(Pt 1):281-8.
2000: Benjamin Moreno; Julio A Urbina; Eric Oldfield; Brian N Bailey; Claudia Rodrigues; Roberto Docampo
31P NMR spectroscopy of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major. Evidence for high levels of condensed inorganic phosphates.
The Journal of biological chemistry 2000;275(37):28356-62.
2000: David A Scott; Roberto Docampo
Characterization of isolated acidocalcisomes of Trypanosoma cruzi.
The Journal of biological chemistry 2000;275(31):24215-21.
2000: Roberto Docampo
New and re-emerging diseases: a dedication to Norman D. Levine.
Parasitology today (Personal ed.) 2000;16(8):316-7.
2000: Anibal E Vercesi; Claudia Rodrigues; Rosana Catisti; Roberto Docampo
Presence of a Na(+)/H(+) exchanger in acidocalcisomes of Leishmania donovani and their alkalization by anti-leishmanial drugs.
FEBS letters 2000;473(2):203-6.
2000: Sergio H Szajnman; W Yan; Brian N Bailey; Roberto Docampo; Eleonora Elhalem; Juan B Rodriguez
Design and synthesis of aryloxyethyl thiocyanate derivatives as potent inhibitors of Trypanosoma cruzi proliferation.
Journal of medicinal chemistry 2000;43(9):1826-40.
2000: Kildare Miranda; Marlene Benchimol; Roberto Docampo; Wanderley de Souza
The fine structure of acidocalcisomes in Trypanosoma cruzi.
Parasitology research 2000;86(5):373-84.
2000: Norma Marchesini; Shuhong Luo; Claudia Rodrigues; Silvia N J Moreno; Roberto Docampo
Acidocalcisomes and a vacuolar H+-pyrophosphatase in malaria parasites.
The Biochemical journal 2000;347 Pt 1():243-53.
2000: Sergio A Uyemura; Shuhong Luo; Silvia N J Moreno; Roberto Docampo
Oxidative phosphorylation, Ca(2+) transport, and fatty acid-induced uncoupling in malaria parasites mitochondria.
The Journal of biological chemistry 2000;275(13):9709-15.
2000: T Furuya; C Kashuba; Roberto Docampo; Silvia N J Moreno
A novel phosphatidylinositol-phospholipase C of Trypanosoma cruzi that is lipid modified and activated during trypomastigote to amastigote differentiation.
The Journal of biological chemistry 2000;275(9):6428-38.
2000: N Vanderheyden; Gerald McLaughlin; Roberto Docampo
Regulation of the plasma membrane potential in Pneumocystis carinii.
FEMS microbiology letters 2000;183(2):327-30.
2000: N Vanderheyden; J Wong; Roberto Docampo
A pyruvate-proton symport and an H+-ATPase regulate the intracellular pH of Trypanosoma brucei at different stages of its life cycle.
The Biochemical journal 2000;346 Pt 1():53-62.
2000: Rosana Catisti; Sergio A Uyemura; Roberto Docampo; Anibal E Vercesi
Calcium mobilization by arachidonic acid in trypanosomatids.
Molecular and biochemical parasitology 2000;105(2):261-71.
2000: Nicole Van Der Heyden; Roberto Docampo
Intracellular pH in mammalian stages of Trypanosoma cruzi is K+-dependent and regulated by H+-ATPases.
Molecular and biochemical parasitology 2000;105(2):237-51.
2000: Juan B Rodriguez; Roberto Docampo; Eduardo G Gros
Sulphur-containing derivatives structurally related to fenoxycarb are potent growth inhibitors against the intracellular form of Trypanosoma cruzi.
International journal of antimicrobial agents 2000;13(3):215-8.
1999: Julio A Urbina; Benjamin Moreno; S Vierkotter; Eric Oldfield; gilberto payares; cristina sanoja; Brian N Bailey; W Yan; David A Scott; Silvia N J Moreno; Roberto Docampo
Trypanosoma cruzi contains major pyrophosphate stores, and its growth in vitro and in vivo is blocked by pyrophosphate analogs.
The Journal of biological chemistry 1999;274(47):33609-15.
1999: Claudia Rodrigues; David A Scott; Roberto Docampo
Characterization of a vacuolar pyrophosphatase in Trypanosoma brucei and its localization to acidocalcisomes.
Molecular and cellular biology 1999;19(11):7712-23.
1999: Roberto Docampo; Silvia N J Moreno
Acidocalcisome: A novel Ca2+ storage compartment in trypanosomatids and apicomplexan parasites.
Parasitology today (Personal ed.) 1999;15(11):443-8.
1999: Shuhong Luo; Norma Marchesini; Silvia N J Moreno; Roberto Docampo
A plant-like vacuolar H(+)-pyrophosphatase in Plasmodium falciparum.
FEBS letters 1999;460(2):217-20.
1999: Julio F Turrens; C L Newton; L Zhong; F R Hernandez; J Whitfield; Roberto Docampo
Mercaptopyridine-N-oxide, an NADH-fumarate reductase inhibitor, blocks Trypanosoma cruzi growth in culture and in infected myoblasts.
FEMS microbiology letters 1999;175(2):217-21.
1999: Claudia Rodrigues; David A Scott; Roberto Docampo
Presence of a vacuolar H+-pyrophosphatase in promastigotes of Leishmania donovani and its localization to a different compartment from the vacuolar H+-ATPase.
The Biochemical journal 1999;340 ( Pt 3)():759-66.
1998: Juan B Rodriguez; L Zhong; Roberto Docampo; Z Wimmer; Eduardo G Gros
Growth inhibitory effect of juvenile hormone analogues on epimastigotes of Trypanosoma cruzi.
Bioorganic & medicinal chemistry letters 1998;8(22):3257-60.
1998: David A Scott; Wanderley de Souza; Marlene Benchimol; L Zhong; HG Lu; Silvia N J Moreno; Roberto Docampo
Presence of a plant-like proton-pumping pyrophosphatase in acidocalcisomes of Trypanosoma cruzi.
The Journal of biological chemistry 1998;273(34):22151-8.
1998: Marlene Benchimol; Wanderley de Souza; N Vanderheyden; L Zhong; HG Lu; Silvia N J Moreno; Roberto Docampo
Functional expression of a vacuolar-type H+-ATPase in the plasma membrane and intracellular vacuoles of Trypanosoma cruzi.
The Biochemical journal 1998;332 ( Pt 3)():695-702.
1998: D A Scott; Roberto Docampo; M Benchimol
Analysis of the uptake of the fluorescent marker 2',7'-bis-(2-carboxyethyl)-5(and-6)-carboxyfluorescein (BCECF) by hydrogenosomes in Trichomonas vaginalis.
European journal of cell biology 1998;76(2):139-45.
1998: T Furuya; L Zhong; J R Meyer-Fernandes; HG Lu; Silvia N J Moreno; Roberto Docampo
Ecto-protein tyrosine phosphatase activity in Trypanosoma cruzi infective stages.
Molecular and biochemical parasitology 1998;92(2):339-48.
1998: G M Cinque; Sergio H Szajnman; L Zhong; Roberto Docampo; A J Schvartzapel; Juan B Rodriguez; Eduardo G Gros
Structure-activity relationship of new growth inhibitors of Trypanosoma cruzi.
Journal of medicinal chemistry 1998;41(9):1540-54.
1998: David A Scott; Roberto Docampo
Two types of H+-ATPase are involved in the acidification of internal compartments in Trypanosoma cruzi.
The Biochemical journal 1998;331 ( Pt 2)():583-9.
1998: L Zhong; HG Lu; Silvia N J Moreno; Roberto Docampo
Tyrosine phosphate hydrolysis of host proteins by Trypanosoma cruzi is linked to cell invasion.
FEMS microbiology letters 1998;161(1):15-20.
1998: HG Lu; L Zhong; Wanderley de Souza; Marlene Benchimol; Silvia N J Moreno; Roberto Docampo
Ca2+ content and expression of an acidocalcisomal calcium pump are elevated in intracellular forms of Trypanosoma cruzi.
Molecular and cellular biology 1998;18(4):2309-23.
1997: Anibal E Vercesi; MT Grijalba; Roberto Docampo
Inhibition of Ca2+ release from Trypanosoma brucei acidocalcisomes by 3,5-dibutyl-4-hydroxytoluene: role of the Na+/H+ exchanger.
The Biochemical journal 1997;328 ( Pt 2)():479-82.
1997: David A Scott; Roberto Docampo; J A Dvorak; S Shi; Richard Leapman
In situ compositional analysis of acidocalcisomes in Trypanosoma cruzi.
The Journal of biological chemistry 1997;272(44):28020-9.
1997: A J Schvartzapel; L Zhong; Roberto Docampo; Juan B Rodriguez; Eduardo G Gros
Design, synthesis, and biological evaluation of new growth inhibitors of Trypanosoma cruzi (epimastigotes).
Journal of medicinal chemistry 1997;40(15):2314-22.
1997: Julio A Urbina; Gonzalo Visbal; L M Contreras; G McLaughlin; Roberto Docampo
Inhibitors of delta24(25) sterol methyltransferase block sterol synthesis and cell proliferation in Pneumocystis carinii.
Antimicrobial agents and chemotherapy 1997;41(7):1428-32.
1997: HG Lu; L Zhong; K P Chang; Roberto Docampo
Intracellular Ca2+ pool content and signaling and expression of a calcium pump are linked to virulence in Leishmania mexicana amazonesis amastigotes.
The Journal of biological chemistry 1997;272(14):9464-73.
1997: Roberto Docampo; G A Schmuñis
Sterol biosynthesis inhibitors: potential chemotherapeutics against Chagas disease.
Parasitology today (Personal ed.) 1997;13(4):129-30.
1996: Julio F Turrens; B P Watts; L Zhong; Roberto Docampo
Inhibition of Trypanosoma cruzi and T. brucei NADH fumarate reductase by benznidazole and anthelmintic imidazole derivatives.
Molecular and biochemical parasitology 1996;82(1):125-9.
1996: N Vanderheyden; Gustavo Benaim; Roberto Docampo
The role of a H(+)-ATPase in the regulation of cytoplasmic pH in Trypanosoma cruzi epimastigotes.
The Biochemical journal 1996;318 ( Pt 1)():103-9.
1996: M Suju; M Davila; G Poleo; Roberto Docampo; Gustavo Benaim
Phosphatidylethanol stimulates the plasma-membrane calcium pump from human erythrocytes.
The Biochemical journal 1996;317 ( Pt 3)():933-8.
1996: Roberto Docampo; N M Vanderheyden; MM Shaw; Pamela J Durant; Marilyn S Bartlett; James W Smith; Gerald McLaughlin
An H(+)-ATPase regulates cytoplasmic pH in Pneumocystis carinii trophozoites.
The Biochemical journal 1996;316 ( Pt 2)():681-4.
1996: Anibal E Vercesi; Roberto Docampo
Sodium-proton exchange stimulates Ca2+ release from acidocalcisomes of Trypanosoma brucei.
The Biochemical journal 1996;315 ( Pt 1)():265-70.
1996: Roberto Docampo; Silvia N J Moreno
The role of Ca2+ in the process of cell invasion by intracellular parasites.
Parasitology today (Personal ed.) 1996;12(2):61-5.
1995: D A Scott; Silvia N J Moreno; Roberto Docampo
Ca2+ storage in Trypanosoma brucei: the influence of cytoplasmic pH and importance of vacuolar acidity.
The Biochemical journal 1995;310 ( Pt 3)():789-94.
1995: Roberto Docampo; D A Scott; Anibal E Vercesi; Silvia N J Moreno
Intracellular Ca2+ storage in acidocalcisomes of Trypanosoma cruzi.
The Biochemical journal 1995;310 ( Pt 3)():1005-12.
1995: M E Hoffmann; J Jang; Silvia N J Moreno; Roberto Docampo
Inhibition of protein synthesis and amino acid transport by crystal violet in Trypanosoma cruzi.
The Journal of eukaryotic microbiology 1995;42(3):293-7.
1995: Gustavo Benaim; Silvia N J Moreno; G Hutchinson; Vincenza Cervino; Tomas Hermoso; Pedro J Romero; F Ruiz; W de Souza; Roberto Docampo
Characterization of the plasma-membrane calcium pump from Trypanosoma cruzi.
The Biochemical journal 1995;306 ( Pt 1)():299-303.
1994: Anibal E Vercesi; Silvia N J Moreno; Roberto Docampo
Ca2+/H+ exchange in acidic vacuoles of Trypanosoma brucei.
The Biochemical journal 1994;304 ( Pt 1)():227-33.
1994: Silvia N J Moreno; J Silva; Anibal E Vercesi; Roberto Docampo
Cytosolic-free calcium elevation in Trypanosoma cruzi is required for cell invasion.
The Journal of experimental medicine 1994;180(4):1535-40.
1994: Silvia N J Moreno; E G Carnieri; Roberto Docampo
Inhibition of Trypanosoma cruzi trypanothione reductase by crystal violet.
Molecular and biochemical parasitology 1994;67(2):313-20.
1993: Gustavo Benaim; C Lopez-Estraño; Roberto Docampo; Silvia N J Moreno
A calmodulin-stimulated Ca2+ pump in plasma-membrane vesicles from Trypanosoma brucei; selective inhibition by pentamidine.
The Biochemical journal 1993;296 ( Pt 3)():759-63.
1993: E G Carnieri; Silvia N J Moreno; Roberto Docampo
Trypanothione-dependent peroxide metabolism in Trypanosoma cruzi different stages.
Molecular and biochemical parasitology 1993;61(1):79-86.
1993: Roberto Docampo; Silvia N J Moreno; Anibal E Vercesi
Effect of thapsigargin on calcium homeostasis in Trypanosoma cruzi trypomastigotes and epimastigotes.
Molecular and biochemical parasitology 1993;59(2):305-13.
1993: Roberto Docampo; F R Gadelha; Silvia N J Moreno; Gustavo Benaim; M E Hoffmann; Anibal E Vercesi
Disruption of Ca2+ homeostasis in Trypanosoma cruzi by crystal violet.
The Journal of eukaryotic microbiology 1993;40(3):311-6.
1993: Anibal E Vercesi; Silvia N J Moreno; C F Bernardes; AR Meinicke; E C Fernandes; Roberto Docampo
Thapsigargin causes Ca2+ release and collapse of the membrane potential of Trypanosoma brucei mitochondria in situ and of isolated rat liver mitochondria.
The Journal of biological chemistry 1993;268(12):8564-8.
1993: Anibal E Vercesi; M E Hoffmann; C F Bernardes; Roberto Docampo
ATP and Ca2+ homeostasis in Trypanosoma cruzi.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 1993;26(4):355-63.
1993: Roberto Docampo
Calcium homeostasis in Trypanosoma cruzi.
Biological research 1993;26(1-2):189-96.
1992: Anibal E Vercesi; Roberto Docampo; Silvia N J Moreno
Energization-dependent Ca2+ accumulation in Trypanosoma brucei bloodstream and procyclic trypomastigotes mitochondria.
Molecular and biochemical parasitology 1992;56(2):251-7.
1992: F R Gadelha; P M Hanna; R P Mason; Roberto Docampo
Evidence for free radical formation during horseradish peroxidase-catalyzed N-demethylation of crystal violet.
Chemico-biological interactions 1992;85(1):35-48.
1992: Silvia N J Moreno; Anibal E Vercesi; O P Pignataro; Roberto Docampo
Calcium homeostasis in Trypanosoma cruzi amastigotes: presence of inositol phosphates and lack of an inositol 1,4,5-trisphosphate-sensitive calcium pool.
Molecular and biochemical parasitology 1992;52(2):251-61.
1992: Anibal E Vercesi; Roberto Docampo
Ca2+ transport by digitonin-permeabilized Leishmania donovani. Effects of Ca2+, pentamidine and WR-6026 on mitochondrial membrane potential in situ.
The Biochemical journal 1992;284 ( Pt 2)():463-7.
1992: Silvia N J Moreno; Roberto Docampo; Anibal E Vercesi
Calcium homeostasis in procyclic and bloodstream forms of Trypanosoma brucei. Lack of inositol 1,4,5-trisphosphate-sensitive Ca2+ release.
The Journal of biological chemistry 1992;267(9):6020-6.
1991: Gustavo Benaim; S Losada; F R Gadelha; Roberto Docampo
A calmodulin-activated (Ca(2+)-Mg2+)-ATPase is involved in Ca2+ transport by plasma membrane vesicles from Trypanosoma cruzi.
The Biochemical journal 1991;280 ( Pt 3)():715-20.
1991: Anibal E Vercesi; C F Bernardes; M E Hoffmann; F R Gadelha; Roberto Docampo
Digitonin permeabilization does not affect mitochondrial function and allows the determination of the mitochondrial membrane potential of Trypanosoma cruzi in situ.
The Journal of biological chemistry 1991;266(22):14431-4.
1991: Anibal E Vercesi; M E Hoffmann; C F Bernardes; Roberto Docampo
Regulation of intracellular calcium homeostasis in Trypanosoma cruzi. Effects of calmidazolium and trifluoperazine.
Cell calcium 1991;12(5):361-9.
1991: Roberto Docampo; O P Pignataro
The inositol phosphate/diacylglycerol signalling pathway in Trypanosoma cruzi.
The Biochemical journal 1991;275 ( Pt 2)():407-11.
1990: Anibal E Vercesi; D V Macedo; S A Lima; F R Gadelha; Roberto Docampo
Ca2+ transport in digitonin-permeabilized trypanosomatids.
Molecular and biochemical parasitology 1990;42(1):119-24.
1990: Roberto Docampo
Sensitivity of parasites to free radical damage by antiparasitic drugs.
Chemico-biological interactions 1990;73(1):1-27.
1990: Roberto Docampo; Silvia N J Moreno
The metabolism and mode of action of gentian violet.
Drug metabolism reviews 1990;22(2-3):161-78.
1989: Roberto Docampo; A E Vercesi
Characteristics of Ca2+ transport by Trypanosoma cruzi mitochondria in situ.
Archives of biochemistry and biophysics 1989;272(1):122-9.
1989: F R Gadelha; Silvia N J Moreno; Wanderley de Souza; F S Cruz; Roberto Docampo
The mitochondrion of Trypanosoma cruzi is a target of crystal violet toxicity.
Molecular and biochemical parasitology 1989;34(2):117-26.
1989: Roberto Docampo; A E Vercesi
Ca2+ transport by coupled Trypanosoma cruzi mitochondria in situ.
The Journal of biological chemistry 1989;264(1):108-11.
1988: Roberto Docampo; Silvia N J Moreno; F R Gadelha; Wanderley de Souza; F S Cruz
Prevention of Chagas' disease resulting from blood transfusion by treatment of blood: toxicity and mode of action of gentian violet.
Biomedical and environmental sciences : BES 1988;1(4):406-13.
1988: Silvia N J Moreno; F R Gadelha; Roberto Docampo
Crystal violet as an uncoupler of oxidative phosphorylation in rat liver mitochondria.
The Journal of biological chemistry 1988;263(25):12493-9.
1988: Roberto Docampo; Silvia N J Moreno; F S Cruz
Enhancement of the cytotoxicity of crystal violet against Trypanosoma cruzi in the blood by ascorbate.
Molecular and biochemical parasitology 1988;27(2-3):241-7.
1988: Silvia N J Moreno; Roberto Docampo
Reduction of 5-nitroimidazoles, nitrofurazone, and 2,4-dinitrophenol to their free radical metabolites by Tritrichomonas foetus hydrogenosomes.
Basic life sciences 1988;49():759-64.
1988: Roberto Docampo; Silvia N J Moreno; Ronald P Mason
Generation of superoxide anion and hydrogen peroxide during redox cycling of 5-(4-nitrophenyl)-penta-2,4-dienal by mammalian microsomes and enzymes.
Chemico-biological interactions 1988;65(2):123-31.
1987: Roberto Docampo; Silvia N J Moreno; R P Mason
Free radical intermediates in the reaction of pyruvate:ferredoxin oxidoreductase in Tritrichomonas foetus hydrogenosomes.
The Journal of biological chemistry 1987;262(26):12417-20.
1987: S M Albónico; M E Assem; I A Benages; A A Montiel; M T Pizzorno; Roberto Docampo; Andrés O M Stoppani
Synthetic trypanocides: growth-inhibiting properties of new 1,2,3,4-tetrahydrocarbazoles on Trypanosoma cruzi.
Revista Argentina de microbiología 1987;19(3):121-4.
1986: J J Marr; Roberto Docampo
Chemotherapy for Chagas' disease: a perspective of current therapy and considerations for future research.
Reviews of infectious diseases 1986;8(6):884-903.
1986: Roberto Docampo; Silvia N J Moreno
Free radical metabolism of antiparasitic agents.
Federation proceedings 1986;45(10):2471-6.
1986: K Reszka; F S Cruz; Roberto Docampo
Photosensitization by the trypanocidal agent crystal violet. Type I versus type II reactions.
Chemico-biological interactions 1986;58(2):161-72.
1986: Silvia N J Moreno; Roberto Docampo
Reduction of the metallochromic indicators murexide and tetramethylmurexide to their free radical metabolites by cytoplasmic enzymes and reducing agents.
Chemico-biological interactions 1986;57(1):17-25.
1985: Silvia N J Moreno; Roberto Docampo
Mechanism of toxicity of nitro compounds used in the chemotherapy of trichomoniasis.
Environmental health perspectives 1985;64():199-208.
1985: Silvia N J Moreno; R P Mason; Roberto Docampo
Reduction of the metallochromic indicators arsenazo III and antipyrylazo III to their free radical metabolites by cytoplasmic enzymes.
FEBS letters 1985;180(2):229-33.
1985: Rita L Cardoni; E H de Titto; Roberto Docampo
On the mechanism of killing of Trypanosoma cruzi by human polymorphonuclear leukocytes.
Experientia 1985;41(1):89-91.
1984: Silvia N J Moreno; R P Mason; Roberto Docampo
Ca2+ and Mg2+-enhanced reduction of arsenazo III to its anion free radical metabolite and generation of superoxide anion by an outer mitochondrial membrane azoreductase.
The Journal of biological chemistry 1984;259(23):14609-16.
1984: Silvia N J Moreno; R P Mason; Roberto Docampo
Distinct reduction of nitrofurans and metronidazole to free radical metabolites by Tritrichomonas foetus hydrogenosomal and cytosolic enzymes.
The Journal of biological chemistry 1984;259(13):8252-9.
1984: F S Cruz; L A Lopes; W De Souza; Silvia N J Moreno; R P Mason; Roberto Docampo
The photodynamic action of rose bengal on Trypanosoma cruzi.
Acta tropica 1984;41(2):99-108.
1984: Silvia N J Moreno; R P Mason; Roberto Docampo
Reduction of nifurtimox and nitrofurantoin to free radical metabolites by rat liver mitochondria. Evidence of an outer membrane-located nitroreductase.
The Journal of biological chemistry 1984;259(10):6298-305.
1984: Roberto Docampo; Silvia N J Moreno
Free radical metabolites in the mode of action of chemotherapeutic agents and phagocytic cells on Trypanosoma cruzi.
Reviews of infectious diseases 1984;6(2):223-38.
1983: Roberto Docampo; Silvia N J Moreno; R P Mason
Generation of free radical metabolites and superoxide anion by the calcium indicators arsenazo III, antipyrylazo III, and murexide in rat liver microsomes.
The Journal of biological chemistry 1983;258(24):14920-5.
1983: Roberto Docampo; Silvia N J Moreno; R P Muniz; F S Cruz; R P Mason
Light-enhanced free radical formation and trypanocidal action of gentian violet (crystal violet).
Science (New York, N.Y.) 1983;220(4603):1292-5.
1983: Roberto Docampo; A M Casellas; E D Madeira; R L Cardoni; Silvia N J Moreno; R P Mason
Oxygen-derived radicals from Trypanosoma cruzi-stimulated human neutrophils.
FEBS letters 1983;155(1):25-30.
1983: Silvia N J Moreno; R P Mason; R P Muniz; F S Cruz; Roberto Docampo
Generation of free radicals from metronidazole and other nitroimidazoles by Tritrichomonas foetus.
The Journal of biological chemistry 1983;258(7):4051-4.
1983: M Dubin; Silvia N J Moreno; E E Martino; Roberto Docampo; A O Stoppani
Increased biliary secretion and loss of hepatic glutathione in rat liver after nifurtimox treatment.
Biochemical pharmacology 1983;32(3):483-7.
1983: Roberto Docampo; M Dubin; E E Martino; Silvia N J Moreno; A O Stoppani
[Influence of nifurtimox on the glutathione content of the liver and bile in rats].
Medicina 1983;43(1):33-40.
1983: Silvia N J Moreno; Roberto Docampo; A O Stoppani
[Undesirable effects of benznidazole and nifurtimox].
Medicina 1983;43(3):291-5.
1982: Silvia N J Moreno; Roberto Docampo; R P Mason; W Leon; A O Stoppani
Different behaviors of benznidazole as free radical generator with mammalian and Trypanosoma cruzi microsomal preparations.
Archives of biochemistry and biophysics 1982;218(2):585-91.
1982: J J Cannata; E Valle; Roberto Docampo; Juan J Cazzulo
Subcellular localization of phosphoenolpyruvate carboxykinase in the trypanosomatids Trypanosoma cruzi and Crithidia fasciculata.
Molecular and biochemical parasitology 1982;6(3):151-60.
1982: R L Cardoni; Roberto Docampo; A M Casellas
Metabolic requirements for the damage of Trypanosoma cruzi epimastigotes by human polymorphonuclear leukocytes.
The Journal of parasitology 1982;68(4):547-52.
1982: T A Salzman; A M Stella; E A Wider de Xifra; Alcira Batlle; Roberto Docampo; A O Stoppani
Porphyrin biosynthesis in parasitic hemoflagellates: functional and defective enzymes in Trypanosoma cruzi.
Comparative biochemistry and physiology. B, Comparative biochemistry 1982;72(4):663-7.
1981: Roberto Docampo; R P Mason; C Mottley; R P Muniz
Generation of free radicals induced by nifurtimox in mammalian tissues.
The Journal of biological chemistry 1981;256(21):10930-3.
1981: Roberto Docampo; Silvia N J Moreno; A O Stoppani; W Leon; F S Cruz; Fernando Villalta; R F Muniz
Mechanism of nifurtimox toxicity in different forms of Trypanosoma cruzi.
Biochemical pharmacology 1981;30(14):1947-51.
1981: Roberto Docampo; Silvia N J Moreno; J F Turrens; Alejandro M Katzin; S M Gonzalez-Cappa; A O Stoppani
Biochemical and ultrastructural alterations produced by miconazole and econazole in Trypanosoma cruzi.
Molecular and biochemical parasitology 1981;3(3):169-80.
1981: Roberto Docampo; Silvia N J Moreno; A O Stoppani
Nitrofuran enhancement of microsomal electron transport, superoxide anion production and lipid peroxidation.
Archives of biochemistry and biophysics 1981;207(2):316-24.
1980: A O Stoppani; Roberto Docampo; J F de Boiso; A C Frasch
Effect of inhibitors of electron transport and oxidative phosphorylation on Trypanosoma cruzi respiration and growth.
Molecular and biochemical parasitology 1980;2(1):3-21.
1980: Silvia N J Moreno; D J Palmero; K Eiguchi de Palmero; Roberto Docampo; A O Stoppani
[Stimulation of lipid peroxidation and ultrastructural changes induced by nifurtimox in mammalian tissue].
Medicina 1980;40(5):553-9.
1980: A Boveris; H Sies; E E Martino; Roberto Docampo; J F Turrens; A O Stoppani
Deficient metabolic utilization of hydrogen peroxide in Trypanosoma cruzi.
The Biochemical journal 1980;188(3):643-8.
1980: A M Gonçalves; M E Vasconcellos; Roberto Docampo; F S Cruz; W de Souza; W Leon
Evaluation of the toxicity of 3-allyl-beta-lapachone against Trypanosoma cruzi bloodstream forms.
Molecular and biochemical parasitology 1980;1(3):167-76.
1980: Juan J Cazzulo; E Valle; Roberto Docampo; J J Cannata
Intracellular distribution of carbon dioxide-fixing enzymes in Trypanosoma cruzi and Crithidia fasciculata.
Journal of general microbiology 1980;117(1):271-4.
1980: J J Cannata; Roberto Docampo; E Valle; B M Franke de Cazzulo; Juan J Cazzulo
[Intracellular distribution of CO2-fixing enzymes in Trypanosoma cruzi and Crithidia fasciculata].
Medicina 1980;40 Suppl 1():145-53.
1980: Roberto Docampo; A O Stoppani
[Mechanism of the trypanocidal action of nifurtimox and other nitro-derivatives on Trypanosoma cruzi].
Medicina 1980;40 Suppl 1():10-6.
1979: Roberto Docampo; A O Stoppani
Generation of superoxide anion and hydrogen peroxide induced by nifurtimox in Trypanosoma cruzi.
Archives of biochemistry and biophysics 1979;197(1):317-21.
1979: W de Souza; T Souto-Padrón; Roberto Docampo; L Chaves; W Leon
The presence of basic proteins associated to the kinetoplast-DNA of Trypanosoma cruzi epimastigotes. Short communication.
Acta tropica 1979;36(3):254-5.
1979: J F de Boiso; Roberto Docampo; A O Stoppani; A C Frasch
[Effect of antimycin A on the respiration and growth of Trypanosoma cruzi].
Medicina 1979;39(3):362-8.
1979: Roberto Docampo; F S Cruz; W Leon; G A Schmunis
Acetate oxidation by bloodstream forms of Trypanosoma cruzi.
The Journal of protozoology 1979;26(2):301-3.
1979: Roberto Docampo; F S Cruz; A Boveris; R P Muniz; D M Esquivel
beta-Lapachone enhancement of lipid peroxidation and superoxide anion and hydrogen peroxide formation by sarcoma 180 ascites tumor cells.
Biochemical pharmacology 1979;28(6):723-8.
1979: J F De Boiso; Roberto Docampo; A O Stoppani
[Cytochromes in epimastigote form of Trypanosoma cruzi].
Revista Argentina de microbiología 1979;11(1):22-36.
1978: F S Cruz; Roberto Docampo; A Boveris
Drugs inducing generation of free radicals in Trypanosoma cruzi [proceedings].
Anais da Academia Brasileira de Ciências 1978;50(4):598.
1978: J N Lopes; F S Cruz; Roberto Docampo; M E Vasconcellos; M C Sampaio; A V Pinto; B Gilbert
In vitro and in vivo evaluation of the toxicity of 1,4-naphthoquinone and 1,2-naphthoquinone derivatives against Trypanosoma cruzi.
Annals of tropical medicine and parasitology 1978;72(6):523-31.
1978: Roberto Docampo; W De Souza; F S Cruz; I Roitman; B Cover; W E Gutteridge
Ultrastructural alterations and peroxide formation induced by naphthoquinones in different stages of Trypanosoma cruzi.
Zeitschrift für Parasitenkunde (Berlin, Germany) 1978;57(3):189-98.
1978: A Boveris; Roberto Docampo; J F Turrens; A O Stoppani
Effect of beta-lapachone on superoxide anion and hydrogen peroxide production in Trypanosoma cruzi.
The Biochemical journal 1978;175(2):431-9.
1978: F S Cruz; Roberto Docampo; A Boveris
Generation of superoxide anions and hydrogen peroxide from beta-lapachone in bacteria.
Antimicrobial agents and chemotherapy 1978;14(4):630-3.
1978: Roberto Docampo; F S Cruz; R P Muniz; D M Esquivel; M E de Vasconcellos
Generation of free radicals from phenazine methosulfate in Trypanosoma cruzi epimastigotes.
Acta tropica 1978;35(3):221-37.
1978: L Leon; M E Vasconcellos; W Leon; F S Cruz; Roberto Docampo; W de Souza
Trypanosoma cruzi: effect of olivacine on macromolecular synthesis, ultrastructure, and respiration of epimastigotes.
Experimental parasitology 1978;45(2):151-9.
1978: Roberto Docampo; J F de Boiso; A O Stoppani
Tricarboxylic acid cycle operation at the kinetoplast-mitochondrion complex of Trypanosoma cruzi.
Biochimica et biophysica acta 1978;502(3):466-76.
1978: Roberto Docampo; F S Cruz; A Boveris; R P Muniz; D M Esquivel
Lipid peroxidation and the generation of free radicals, superoxide anion, and hydrogen peroxide in beta-lapachone-treated Trypanosoma cruzi epimastigotes.
Archives of biochemistry and biophysics 1978;186(2):292-7.
1978: F S Cruz; Roberto Docampo; W de Souza
Effect of beta-lapachone on hydrogen peroxide production in Trypanosoma cruzi.
Acta tropica 1978;35(1):35-40.
1978: A Boveris; A O Stoppani; Roberto Docampo; F S Cruz
Superoxide anion production and trypanocidal action of naphthoquinones on Trypanosoma cruzi.
Comparative biochemistry and physiology. C: Comparative pharmacology 1978;61 C(2):327-9.
1977: Roberto Docampo; J N Lopes; F S Cruz; W Souza
Trypanosoma cruzi: ultrastructural and metabolic alterations of epimastigotes by beta-lapachone.
Experimental parasitology 1977;42(1):142-9.
1977: A Boveris; Roberto Docampo; J F Turrens; A O Stoppani
[Effect of beta and alpha-lapachone on the production of H202 and on the growth of Trypanosoma cruzi].
Revista de la Asociación Argentina de Microbiología 1977;9(2):54-61.
1976: Roberto Docampo; J F de Boiso; A Boveris; A O Stoppani
Localization of peroxidase activity in Trypanosoma cruzi microbodies.
Experientia 1976;32(8):972-5.
1974: Roberto Docampo; J F de Boiso; A O Stoppani
[Metabolic changes in diskinetoplastic Trypanosoma cruzi by ethidium bromide action].
Medicina 1974;34(5):525-31.
1974: J F de Boiso; Roberto Docampo; A O Stoppani
[Ultrastructure of Trypanosoma cruzi with scanning and transmission electromicroscopy].
Revista de la Asociación Argentina de Microbiología 1974;6(3):119-26.
1974: Roberto Docampo; J F de Boiso; A O Stoppani
[Metabolic differences in Trypanosoma cruzi depending of the culturing conditions].
Revista de la Asociación Argentina de Microbiología 1974;6(1):7-14.