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Andrew Docherty

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Chemicals & Drugs

Genes & Molecular Sequences

Amino Acid Sequences

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Gisela Weskamp; Jill W Ford; Jamie L Sturgill; Steve Martin; Andrew J P Docherty; Steven Swendeman; Neil Broadway; Dieter Hartmann; Paul Saftig; Shelby Umland; Atsuko Sehara-Fujisawa; Roy A Black; Andreas Ludwig; J David Becherer; Daniel H Conrad; Carl P Blobel
ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23.
Kristine Kelly; Gillian Hutchinson; Daniela Nebenius-Oosthuizen; Andrew J H Smith; Joerg Walter Bartsch; Keisuke Horiuchi; Andrea Rittger; Katia Manova-Todorova; Andrew J P Docherty; Carl P Blobel
Metalloprotease-disintegrin ADAM8: expression analysis and targeted deletion in mice.
Erika H M Kerkvliet; Ineke D C Jansen; Ton Schoenmaker; Andrew J P Docherty; Wouter Beertsen; Vincent Everts
Low molecular weight inhibitors of matrix metalloproteinases can enhance the expression of matrix metalloproteinase-2 (gelatinase A) without inhibiting its activation.

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All Publications

2006: Gisela Weskamp; Jill W Ford; Jamie L Sturgill; Steve Martin; Andrew J P Docherty; Steven Swendeman; Neil Broadway; Dieter Hartmann; Paul Saftig; Shelby Umland; Atsuko Sehara-Fujisawa; Roy A Black; Andreas Ludwig; J David Becherer; Daniel H Conrad; Carl P Blobel
ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23.
Nature immunology 2006;7(12):1293-8.
2005: Kristine Kelly; Gillian Hutchinson; Daniela Nebenius-Oosthuizen; Andrew J H Smith; Joerg Walter Bartsch; Keisuke Horiuchi; Andrea Rittger; Katia Manova-Todorova; Andrew J P Docherty; Carl P Blobel
Metalloprotease-disintegrin ADAM8: expression analysis and targeted deletion in mice.
Developmental dynamics : an official publication of the American Association of Anatomists 2005;232(1):221-31.
2003: Erika H M Kerkvliet; Ineke D C Jansen; Ton Schoenmaker; Andrew J P Docherty; Wouter Beertsen; Vincent Everts
Low molecular weight inhibitors of matrix metalloproteinases can enhance the expression of matrix metalloproteinase-2 (gelatinase A) without inhibiting its activation.
Cancer 2003;97(6):1582-8.
2002: Uwe Schlomann; Dirk Wildeboer; Ailsa Webster; Olga Antropova; Dagmar Zeuschner; C Graham Knight; Andrew J P Docherty; Marc Lambert; Lisa Skelton; Harald Jockusch; Joerg Walter Bartsch
The metalloprotease disintegrin ADAM8. Processing by autocatalysis is required for proteolytic activity and cell adhesion.
The Journal of biological chemistry 2002;277(50):48210-9.
2002: Augustin Amour; C Graham Knight; William R English; Ailsa Webster; Patrick M Slocombe; Vera Knäuper; Andrew J P Docherty; J David Becherer; Carl P Blobel; Gillian Murphy
The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs.
FEBS letters 2002;524(1-3):154-8.
2001: Vera Knäuper; Margaret L Patterson; F X Gomis-Rüth; B Smith; A Lyons; Andrew J P Docherty; Gillian Murphy
The role of exon 5 in fibroblast collagenase (MMP-1) substrate specificity and inhibitor selectivity.
European journal of biochemistry / FEBS 2001;268(6):1888-96.
2000: Deepa Nath; Patrick M Slocombe; Ailsa Webster; PE Stephens; Andrew J P Docherty; Gillian Murphy
Meltrin gamma(ADAM-9) mediates cellular adhesion through alpha(6)beta(1 )integrin, leading to a marked induction of fibroblast cell motility.
Journal of cell science 2000;113 ( Pt 12)():2319-28.
2000: Augustin Amour; C Graham Knight; Ailsa Webster; Patrick M Slocombe; PE Stephens; Vera Knäuper; Andrew J P Docherty; Gillian Murphy
The in vitro activity of ADAM-10 is inhibited by TIMP-1 and TIMP-3.
FEBS letters 2000;473(3):275-9.
1999: Erika H M Kerkvliet; Andrew J P Docherty; Wouter Beertsen; Vincent Everts
Collagen breakdown in soft connective tissue explants is associated with the level of active gelatinase A (MMP-2) but not with collagenase.
Matrix biology : journal of the International Society for Matrix Biology 1999;18(4):373-80.
1999: Vincent Everts; Wolf Korper; DC Jansen; J Steinfort; I Lammerse; S Heera; Andrew J P Docherty; Wouter Beertsen
Functional heterogeneity of osteoclasts: matrix metalloproteinases participate in osteoclastic resorption of calvarial bone but not in resorption of long bone.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(10):1219-30.
1999: Augustin Amour; Mike Hutton; Vera Knäuper; Patrick M Slocombe; Ailsa Webster; M Butler; C Graham Knight; B J Smith; Andrew J P Docherty; Gillian Murphy
Inhibition of the metalloproteinase domain of mouse TACE.
Annals of the New York Academy of Sciences 1999;878():728-31.
1999: V Everts; Wolf Korper; Andrew J P Docherty; Wouter Beertsen
Matrix metalloproteinase inhibitors block osteoclastic resorption of calvarial bone but not the resorption of long bone.
Annals of the New York Academy of Sciences 1999;878():603-6.
1999: Deepa Nath; Patrick M Slocombe; PE Stephens; A Warn; G R Hutchinson; K M Yamada; Andrew J P Docherty; Gillian Murphy
Interaction of metargidin (ADAM-15) with alphavbeta3 and alpha5beta1 integrins on different haemopoietic cells.
Journal of cell science 1999;112 ( Pt 4)():579-87.
1998: Augustin Amour; Patrick M Slocombe; Ailsa Webster; M Butler; C Graham Knight; B J Smith; PE Stephens; Chris Shelley; Mike Hutton; Vera Knäuper; Andrew J P Docherty; Gillian Murphy
TNF-alpha converting enzyme (TACE) is inhibited by TIMP-3.
FEBS letters 1998;435(1):39-44.
1998: LB Creemers; Ineke D C Jansen; Andrew J P Docherty; J J Reynolds; Wouter Beertsen; Vincent Everts
Gelatinase A (MMP-2) and cysteine proteinases are essential for the degradation of collagen in soft connective tissue.
Matrix biology : journal of the International Society for Matrix Biology 1998;17(1):35-46.
1997: Vera Knäuper; Andrew J P Docherty; B Smith; Harald Tschesche; Gillian Murphy
Analysis of the contribution of the hinge region of human neutrophil collagenase (HNC, MMP-8) to stability and collagenolytic activity by alanine scanning mutagenesis.
FEBS letters 1997;405(1):60-4.
1996: U Gohlke; F X Gomis-Rüth; T Crabbe; Gillian Murphy; Andrew J P Docherty; Wolfram Bode
The C-terminal (haemopexin-like) domain structure of human gelatinase A (MMP2): structural implications for its function.
FEBS letters 1996;378(2):126-30.
1995: J A Allan; Andrew J P Docherty; P J Barker; N S Huskisson; John J Reynolds; Gillian Murphy
Binding of gelatinases A and B to type-I collagen and other matrix components.
The Biochemical journal 1995;309 ( Pt 1)():299-306.
1995: Peter A Hill; Andrew J P Docherty; K M Bottomley; J P O'Connell; J R Morphy; John J Reynolds; Murray C Meikle
Inhibition of bone resorption in vitro by selective inhibitors of gelatinase and collagenase.
The Biochemical journal 1995;308 ( Pt 1)():167-75.
1995: S K Chander; P Antoniw; N R Beeley; B Boyce; T Crabbe; Andrew J P Docherty; J Leonard; B Mason; K Millar; A T Millican
An in vivo model for screening peptidomimetic inhibitors of gelatinase A.
Journal of pharmaceutical sciences 1995;84(4):404-9.
1994: T Crabbe; J P O'Connell; B J Smith; Andrew J P Docherty
Reciprocated matrix metalloproteinase activation: a process performed by interstitial collagenase and progelatinase A.
Biochemistry 1994;33(48):14419-25.
1994: Peter A Hill; Gillian Murphy; Andrew J P Docherty; Rosalind M Hembry; T A Millican; John J Reynolds; Murray C Meikle
The effects of selective inhibitors of matrix metalloproteinases (MMPs) on bone resorption and the identification of MMPs and TIMP-1 in isolated osteoclasts.
Journal of cell science 1994;107 ( Pt 11)():3055-64.
1994: J A Allan; Andrew J P Docherty; Gillian Murphy
The binding of gelatinases A and B to type I collagen yields both high and low affinity sites.
Annals of the New York Academy of Sciences 1994;732():365-6.
1994: Gillian Murphy; F Willenbrock; T Crabbe; M O'Shea; R Ward; Susan Atkinson; J O'Connell; Andrew J P Docherty
Regulation of matrix metalloproteinase activity.
Annals of the New York Academy of Sciences 1994;732():31-41.
1994: T Baker; S Tickle; H Wasan; Andrew J P Docherty; D Isenberg; J Waxman
Serum metalloproteinases and their inhibitors: markers for malignant potential.
British journal of cancer 1994;70(3):506-12.
1994: T Crabbe; Stanley Zucker; Mark Cockett; F Willenbrock; S Tickle; J P O'Connell; J M Scothern; Gillian Murphy; Andrew J P Docherty
Mutation of the active site glutamic acid of human gelatinase A: effects on latency, catalysis, and the binding of tissue inhibitor of metalloproteinases-1.
Biochemistry 1994;33(21):6684-90.
1994: J P O'Connell; F Willenbrock; Andrew J P Docherty; D Eaton; Gillian Murphy
Analysis of the role of the COOH-terminal domain in the activation, proteolytic activity, and tissue inhibitor of metalloproteinase interactions of gelatinase B.
The Journal of biological chemistry 1994;269(21):14967-73.
1994: T Crabbe; B Smith; J O'Connell; Andrew J P Docherty
Human progelatinase A can be activated by matrilysin.
FEBS letters 1994;345(1):14-6.
1994: Gillian Murphy; Q Nguyen; Mark Cockett; Susan J Atkinson; J A Allan; C G Knight; F Willenbrock; Andrew J P Docherty
Assessment of the role of the fibronectin-like domain of gelatinase A by analysis of a deletion mutant.
The Journal of biological chemistry 1994;269(9):6632-6.
1994: Q Nguyen; F Willenbrock; Mark Cockett; M O'Shea; Andrew J P Docherty; Gillian Murphy
Different domain interactions are involved in the binding of tissue inhibitors of metalloproteinases to stromelysin-1 and gelatinase A.
Biochemistry 1994;33(8):2089-95.
1994: Mark Cockett; M L Birch; G Murphy; I R Hart; Andrew J P Docherty
Metalloproteinase domain structure, cellular invasion and metastasis.
Biochemical Society transactions 1994;22(1):55-7.
1993: T Crabbe; C Ioannou; Andrew J P Docherty
Human progelatinase A can be activated by autolysis at a rate that is concentration-dependent and enhanced by heparin bound to the C-terminal domain.
European journal of biochemistry / FEBS 1993;218(2):431-8.
1993: S P Tolley; Gideon J Davies; M O'Shea; Mark Cockett; Andrew J P Docherty; Gillian Murphy
Crystallization and preliminary X-ray analysis of nonglycosylated tissue inhibitor of metalloproteinases-1, N30QN78Q TIMP-1.
Proteins 1993;17(4):435-7.
1993: F Willenbrock; T Crabbe; Patrick M Slocombe; C W Sutton; Andrew J P Docherty; Mark Cockett; M O'Shea; Keith Brocklehurst; Ian R Phillips; Gillian Murphy
The activity of the tissue inhibitors of metalloproteinases is regulated by C-terminal domain interactions: a kinetic analysis of the inhibition of gelatinase A.
Biochemistry 1993;32(16):4330-7.
1993: S Tolley; Gillian Murphy; M O'Shea; R Ward; Andrew J P Docherty; Mark Cockett; A Rawas; G Davies
Crystallization and preliminary X-ray analysis of a truncated tissue metalloproteinase inhibitor delta 128-194 TIMP-2.
Journal of molecular biology 1993;229(4):1163-4.
1992: M O'Shea; F Willenbrock; R A Williamson; Mark Cockett; R B Freedman; John J Reynolds; Andrew J P Docherty; Gillian Murphy
Site-directed mutations that alter the inhibitory activity of the tissue inhibitor of metalloproteinases-1: importance of the N-terminal region between cysteine 3 and cysteine 13.
Biochemistry 1992;31(42):10146-52.
1992: T Crabbe; F Willenbrock; D Eaton; P Hynds; A F Carne; Gillian Murphy; Andrew J P Docherty
Biochemical characterization of matrilysin. Activation conforms to the stepwise mechanisms proposed for other matrix metalloproteinases.
Biochemistry 1992;31(36):8500-7.
1992: Gillian Murphy; Andrew J P Docherty
The matrix metalloproteinases and their inhibitors.
American journal of respiratory cell and molecular biology 1992;7(2):120-5.
1992: Andrew J P Docherty; J O'Connell; T Crabbe; S Angal; Gillian Murphy
The matrix metalloproteinases and their natural inhibitors: prospects for treating degenerative tissue diseases.
Trends in biotechnology 1992;10(6):200-7.
1992: Gillian Murphy; J A Allan; F Willenbrock; Mark Cockett; J P O'Connell; Andrew J P Docherty
The role of the C-terminal domain in collagenase and stromelysin specificity.
The Journal of biological chemistry 1992;267(14):9612-8.
1992: Gillian Murphy; F Willenbrock; R V Ward; Mark Cockett; D Eaton; Andrew J P Docherty
The C-terminal domain of 72 kDa gelatinase A is not required for catalysis, but is essential for membrane activation and modulates interactions with tissue inhibitors of metalloproteinases.
The Biochemical journal 1992;283 ( Pt 3)():637-41.
1991: R V Ward; Susan J Atkinson; Patrick M Slocombe; Andrew J P Docherty; John J Reynolds; Gillian Murphy
Tissue inhibitor of metalloproteinases-2 inhibits the activation of 72 kDa progelatinase by fibroblast membranes.
Biochimica et biophysica acta 1991;1079(2):242-6.
1991: Gillian Murphy; A Houbrechts; Mark Cockett; R A Williamson; M O'Shea; Andrew J P Docherty
The N-terminal domain of tissue inhibitor of metalloproteinases retains metalloproteinase inhibitory activity.
Biochemistry 1991;30(33):8097-102.
1991: Gillian Murphy; Mark Cockett; R V Ward; Andrew J P Docherty
Matrix metalloproteinase degradation of elastin, type IV collagen and proteoglycan. A quantitative comparison of the activities of 95 kDa and 72 kDa gelatinases, stromelysins-1 and -2 and punctuated metalloproteinase (PUMP).
The Biochemical journal 1991;277 ( Pt 1)():277-9.
1990: Andrew J P Docherty; Gillian Murphy
The tissue metalloproteinase family and the inhibitor TIMP: a study using cDNAs and recombinant proteins.
Annals of the rheumatic diseases 1990;49 Suppl 1():469-79.
1987: Gillian Murphy; Mark Cockett; PE Stephens; B J Smith; Andrew J P Docherty
Stromelysin is an activator of procollagenase. A study with natural and recombinant enzymes.
The Biochemical journal 1987;248(1):265-8.
1987: D R Edwards; G Murphy; J J Reynolds; S E Whitham; Andrew J P Docherty; P Angel; J K Heath
Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor.
The EMBO journal 1987;6(7):1899-904.
1986: S E Whitham; Gillian Murphy; P Angel; H J Rahmsdorf; B J Smith; A Lyons; T J Harris; J J Reynolds; P Herrlich; Andrew J P Docherty
Comparison of human stromelysin and collagenase by cloning and sequence analysis.
The Biochemical journal 1986;240(3):913-6.
1985: Andrew J P Docherty; A Lyons; B J Smith; E M Wright; PE Stephens; T J Harris; Gillian Murphy; J J Reynolds
Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity.
Nature 1985;318(6041):66-9.