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Andrew Docherty
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Research Profile (preview)
Chemicals & Drugs
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Physiology
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Network (preview)
33
Murphy, Gillian
13
Cockett, Mark
8
Slocombe, Patrick
6
Stephens, PE
6
Webster, Ailsa
6
Knäuper, Vera
5
Knight, Graham
5
Reynolds, John
5
Beertsen, Wouter
4
Everts, Vincent
4
Amour, Augustin
3
Blobel, Carl
2
Atkinson, Susan
2
Becherer, David
2
Hill, Peter
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Publications
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Geonetwork of Andrew Docherty (preview)
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All Publications
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2006: Weskamp Gisela; Ford Jill W; Sturgill Jamie; Martin Steve; Docherty Andrew J P; Swendeman Steven; Broadway Neil; Hartmann Dieter; Saftig Paul; Umland Shelby; Sehara-Fujisawa Atsuko; Black Roy A; Ludwig Andreas; Becherer J David; Conrad Daniel H; Blobel Carl P
ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23.
Nature immunology 2006;7(12):1293-8.
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2005: Kelly Kristine; Hutchinson Gillian; Nebenius-Oosthuizen Daniela; Smith Andrew J H; Bartsch Jörg W; Horiuchi Keisuke; Rittger Andrea; Manova Katia; Docherty Andy J P; Blobel Carl P
Metalloprotease-disintegrin ADAM8: expression analysis and targeted deletion in mice.
Developmental dynamics : an official publication of the American Association of Anatomists 2005;232(1):221-31.
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2003: Kerkvliet Erika H M; Jansen Ineke D C; Schoenmaker Ton A M; Docherty Andy J P; Beertsen Wollter; Everts Vincent
Low molecular weight inhibitors of matrix metalloproteinases can enhance the expression of matrix metalloproteinase-2 (gelatinase A) without inhibiting its activation.
Cancer 2003;97(6):1582-8.
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2002: Schlomann Uwe; Wildeboer Dirk; Webster Ailsa; Antropova Olga; Zeuschner Dagmar; Knight C Graham; Docherty Andrew J P; Lambert Marc; Skelton Lisa; Jockusch Harald; Bartsch Jörg W
The metalloprotease disintegrin ADAM8. Processing by autocatalysis is required for proteolytic activity and cell adhesion.
The Journal of biological chemistry 2002;277(50):48210-9.
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2002: Amour Augustin; Knight C Graham; English William R; Webster Ailsa; Slocombe Patrick M; Knäuper Vera; Docherty Andrew J P; Becherer J David; Blobel Carl P; Murphy Gillian
The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs.
FEBS letters 2002;524(1-3):154-8.
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2001: Knäuper V; Patterson M L; Gomis-Rüth F X; Smith B; Lyons A; Docherty A J; Murphy G
The role of exon 5 in fibroblast collagenase (MMP-1) substrate specificity and inhibitor selectivity.
European journal of biochemistry / FEBS 2001;268(6):1888-96.
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2000: Nath D; Slocombe P M; Webster A; Stephens P E; Docherty A J; Murphy G
Meltrin gamma(ADAM-9) mediates cellular adhesion through alpha(6)beta(1 )integrin, leading to a marked induction of fibroblast cell motility.
Journal of cell science 2000;113 ( Pt 12)():2319-28.
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2000: Amour A; Knight C G; Webster A; Slocombe P M; Stephens P E; Knäuper V; Docherty A J; Murphy G
The in vitro activity of ADAM-10 is inhibited by TIMP-1 and TIMP-3.
FEBS letters 2000;473(3):275-9.
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1999: Kerkvliet E H; Docherty A J; Beertsen W; Everts V
Collagen breakdown in soft connective tissue explants is associated with the level of active gelatinase A (MMP-2) but not with collagenase.
Matrix biology : journal of the International Society for Matrix Biology 1999;18(4):373-80.
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1999: Everts V; Korper W; Jansen D C; Steinfort J; Lammerse I; Heera S; Docherty A J; Beertsen W
Functional heterogeneity of osteoclasts: matrix metalloproteinases participate in osteoclastic resorption of calvarial bone but not in resorption of long bone.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(10):1219-30.
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1999: Amour A; Hutton M; Knäuper V; Slocombe P M; Webster A; Butler M; Knight C G; Smith B J; Docherty A J; Murphy G
Inhibition of the metalloproteinase domain of mouse TACE.
Annals of the New York Academy of Sciences 1999;878():728-31.
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1999: Everts V; Korper W; Docherty A J; Beertsen W
Matrix metalloproteinase inhibitors block osteoclastic resorption of calvarial bone but not the resorption of long bone.
Annals of the New York Academy of Sciences 1999;878():603-6.
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1999: Nath D; Slocombe P M; Stephens P E; Warn A; Hutchinson G R; Yamada K M; Docherty A J; Murphy G
Interaction of metargidin (ADAM-15) with alphavbeta3 and alpha5beta1 integrins on different haemopoietic cells.
Journal of cell science 1999;112 ( Pt 4)():579-87.
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1998: Amour A; Slocombe P M; Webster A; Butler M; Knight C G; Smith B J; Stephens P E; Shelley C; Hutton M; Knäuper V; Docherty A J; Murphy G
TNF-alpha converting enzyme (TACE) is inhibited by TIMP-3.
FEBS letters 1998;435(1):39-44.
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1998: Creemers L B; Jansen I D; Docherty A J; Reynolds J J; Beertsen W; Everts V
Gelatinase A (MMP-2) and cysteine proteinases are essential for the degradation of collagen in soft connective tissue.
Matrix biology : journal of the International Society for Matrix Biology 1998;17(1):35-46.
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1997: Knäuper V; Docherty A J; Smith B; Tschesche H; Murphy G
Analysis of the contribution of the hinge region of human neutrophil collagenase (HNC, MMP-8) to stability and collagenolytic activity by alanine scanning mutagenesis.
FEBS letters 1997;405(1):60-4.
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1996: Gohlke U; Gomis-Rüth F X; Crabbe T; Murphy G; Docherty A J; Bode W
The C-terminal (haemopexin-like) domain structure of human gelatinase A (MMP2): structural implications for its function.
FEBS letters 1996;378(2):126-30.
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1995: Allan J A; Docherty A J; Barker P J; Huskisson N S; Reynolds J J; Murphy G
Binding of gelatinases A and B to type-I collagen and other matrix components.
The Biochemical journal 1995;309 ( Pt 1)():299-306.
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1995: Hill P A; Docherty A J; Bottomley K M; O'Connell J P; Morphy J R; Reynolds J J; Meikle M C
Inhibition of bone resorption in vitro by selective inhibitors of gelatinase and collagenase.
The Biochemical journal 1995;308 ( Pt 1)():167-75.
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1995: Chander S K; Antoniw P; Beeley N R; Boyce B; Crabbe T; Docherty A J; Leonard J; Mason B; Millar K; Millican A T
An in vivo model for screening peptidomimetic inhibitors of gelatinase A.
Journal of pharmaceutical sciences 1995;84(4):404-9.
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1994: Crabbe T; O'Connell J P; Smith B J; Docherty A J
Reciprocated matrix metalloproteinase activation: a process performed by interstitial collagenase and progelatinase A.
Biochemistry 1994;33(48):14419-25.
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1994: Hill P A; Murphy G; Docherty A J; Hembry R M; Millican T A; Reynolds J J; Meikle M C
The effects of selective inhibitors of matrix metalloproteinases (MMPs) on bone resorption and the identification of MMPs and TIMP-1 in isolated osteoclasts.
Journal of cell science 1994;107 ( Pt 11)():3055-64.
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1994: Baker T; Tickle S; Wasan H; Docherty A; Isenberg D; Waxman J
Serum metalloproteinases and their inhibitors: markers for malignant potential.
British journal of cancer 1994;70(3):506-12.
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1994: Allan J A; Docherty A J; Murphy G
The binding of gelatinases A and B to type I collagen yields both high and low affinity sites.
Annals of the New York Academy of Sciences 1994;732():365-6.
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1994: Murphy G; Willenbrock F; Crabbe T; O'Shea M; Ward R; Atkinson S; O'Connell J; Docherty A
Regulation of matrix metalloproteinase activity.
Annals of the New York Academy of Sciences 1994;732():31-41.
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1994: O'Connell J P; Willenbrock F; Docherty A J; Eaton D; Murphy G
Analysis of the role of the COOH-terminal domain in the activation, proteolytic activity, and tissue inhibitor of metalloproteinase interactions of gelatinase B.
The Journal of biological chemistry 1994;269(21):14967-73.
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1994: Crabbe T; Smith B; O'Connell J; Docherty A
Human progelatinase A can be activated by matrilysin.
FEBS letters 1994;345(1):14-6.
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1994: Crabbe T; Zucker S; Cockett M I; Willenbrock F; Tickle S; O'Connell J P; Scothern J M; Murphy G; Docherty A J
Mutation of the active site glutamic acid of human gelatinase A: effects on latency, catalysis, and the binding of tissue inhibitor of metalloproteinases-1.
Biochemistry 1994;33(21):6684-90.
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1994: Murphy G; Nguyen Q; Cockett M I; Atkinson S J; Allan J A; Knight C G; Willenbrock F; Docherty A J
Assessment of the role of the fibronectin-like domain of gelatinase A by analysis of a deletion mutant.
The Journal of biological chemistry 1994;269(9):6632-6.
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1994: Nguyen Q; Willenbrock F; Cockett M I; O'Shea M; Docherty A J; Murphy G
Different domain interactions are involved in the binding of tissue inhibitors of metalloproteinases to stromelysin-1 and gelatinase A.
Biochemistry 1994;33(8):2089-95.
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1994: Cockett M I; Birch M L; Murphy G; Hart I R; Docherty A J
Metalloproteinase domain structure, cellular invasion and metastasis.
Biochemical Society transactions 1994;22(1):55-7.
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1993: Crabbe T; Ioannou C; Docherty A J
Human progelatinase A can be activated by autolysis at a rate that is concentration-dependent and enhanced by heparin bound to the C-terminal domain.
European journal of biochemistry / FEBS 1993;218(2):431-8.
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1993: Tolley S P; Davies G J; O'Shea M; Cockett M I; Docherty A J; Murphy G
Crystallization and preliminary X-ray analysis of nonglycosylated tissue inhibitor of metalloproteinases-1, N30QN78Q TIMP-1.
Proteins 1993;17(4):435-7.
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1993: Willenbrock F; Crabbe T; Slocombe P M; Sutton C W; Docherty A J; Cockett M I; O'Shea M; Brocklehurst K; Phillips I R; Murphy G
The activity of the tissue inhibitors of metalloproteinases is regulated by C-terminal domain interactions: a kinetic analysis of the inhibition of gelatinase A.
Biochemistry 1993;32(16):4330-7.
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1993: Tolley S; Murphy G; O'Shea M; Ward R; Docherty A; Cockett M; Rawas A; Davies G
Crystallization and preliminary X-ray analysis of a truncated tissue metalloproteinase inhibitor delta 128-194 TIMP-2.
Journal of molecular biology 1993;229(4):1163-4.
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1992: O'Shea M; Willenbrock F; Williamson R A; Cockett M I; Freedman R B; Reynolds J J; Docherty A J; Murphy G
Site-directed mutations that alter the inhibitory activity of the tissue inhibitor of metalloproteinases-1: importance of the N-terminal region between cysteine 3 and cysteine 13.
Biochemistry 1992;31(42):10146-52.
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1992: Crabbe T; Willenbrock F; Eaton D; Hynds P; Carne A F; Murphy G; Docherty A J
Biochemical characterization of matrilysin. Activation conforms to the stepwise mechanisms proposed for other matrix metalloproteinases.
Biochemistry 1992;31(36):8500-7.
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1992: Murphy G; Docherty A J
The matrix metalloproteinases and their inhibitors.
American journal of respiratory cell and molecular biology 1992;7(2):120-5.
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1992: Docherty A J; O'Connell J; Crabbe T; Angal S; Murphy G
The matrix metalloproteinases and their natural inhibitors: prospects for treating degenerative tissue diseases.
Trends in biotechnology 1992;10(6):200-7.
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1992: Murphy G; Willenbrock F; Ward R V; Cockett M I; Eaton D; Docherty A J
The C-terminal domain of 72 kDa gelatinase A is not required for catalysis, but is essential for membrane activation and modulates interactions with tissue inhibitors of metalloproteinases.
The Biochemical journal 1992;283 ( Pt 3)():637-41.
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1992: Murphy G; Allan J A; Willenbrock F; Cockett M I; O'Connell J P; Docherty A J
The role of the C-terminal domain in collagenase and stromelysin specificity.
The Journal of biological chemistry 1992;267(14):9612-8.
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1991: Ward R V; Atkinson S J; Slocombe P M; Docherty A J; Reynolds J J; Murphy G
Tissue inhibitor of metalloproteinases-2 inhibits the activation of 72 kDa progelatinase by fibroblast membranes.
Biochimica et biophysica acta 1991;1079(2):242-6.
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1991: Murphy G; Houbrechts A; Cockett M I; Williamson R A; O'Shea M; Docherty A J
The N-terminal domain of tissue inhibitor of metalloproteinases retains metalloproteinase inhibitory activity.
Biochemistry 1991;30(33):8097-102.
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1991: Murphy G; Cockett M I; Ward R V; Docherty A J
Matrix metalloproteinase degradation of elastin, type IV collagen and proteoglycan. A quantitative comparison of the activities of 95 kDa and 72 kDa gelatinases, stromelysins-1 and -2 and punctuated metalloproteinase (PUMP).
The Biochemical journal 1991;277 ( Pt 1)():277-9.
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1990: Docherty A J; Murphy G
The tissue metalloproteinase family and the inhibitor TIMP: a study using cDNAs and recombinant proteins.
Annals of the rheumatic diseases 1990;49 Suppl 1():469-79.
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1987: Murphy G; Cockett M I; Stephens P E; Smith B J; Docherty A J
Stromelysin is an activator of procollagenase. A study with natural and recombinant enzymes.
The Biochemical journal 1987;248(1):265-8.
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1987: Edwards D R; Murphy G; Reynolds J J; Whitham S E; Docherty A J; Angel P; Heath J K
Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor.
The EMBO journal 1987;6(7):1899-904.
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1986: Whitham S E; Murphy G; Angel P; Rahmsdorf H J; Smith B J; Lyons A; Harris T J; Reynolds J J; Herrlich P; Docherty A J
Comparison of human stromelysin and collagenase by cloning and sequence analysis.
The Biochemical journal 1986;240(3):913-6.
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1985: Docherty A J; Lyons A; Smith B J; Wright E M; Stephens P E; Harris T J; Murphy G; Reynolds J J
Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity.
Nature 1985;318(6041):66-9.
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