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Bhupendra Doctor

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Wei Sun; Prasanthi Tipparaju; Bhupendra P Doctor; Chunyuan Luo; Ashima Saxena
Effect of polyethylene glycol conjugation on the circulatory stability of plasma-derived human butyrylcholinesterase in mice.
Ying Wang; Yanling Wei; Bhupendra P Doctor; Samuel Oguntayo; Madhusoodana P Nambiar
A combination of [+] and [-]-Huperzine A improves protection against soman toxicity compared to [+]-Huperzine A in guinea pigs.
Ramachandra S Naik; Kunjan A Patel; Nagarajan Pattabiraman; Bhupendra P Doctor; Ashima Saxena
Amino acid residues at the N- and C-termini are essential for the folding of active human butyrylcholinesterase polypeptide.

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2013: Wei Sun; Prasanthi Tipparaju; Bhupendra P Doctor; Chunyuan Luo; Ashima Saxena
Effect of polyethylene glycol conjugation on the circulatory stability of plasma-derived human butyrylcholinesterase in mice.
Chemico-biological interactions 2013;203(1):172-6.
2013: Ying Wang; Yanling Wei; Bhupendra P Doctor; Samuel Oguntayo; Madhusoodana P Nambiar
A combination of [+] and [-]-Huperzine A improves protection against soman toxicity compared to [+]-Huperzine A in guinea pigs.
Chemico-biological interactions 2013;203(1):120-4.
2013: Ramachandra S Naik; Kunjan A Patel; Nagarajan Pattabiraman; Bhupendra P Doctor; Ashima Saxena
Amino acid residues at the N- and C-termini are essential for the folding of active human butyrylcholinesterase polypeptide.
Chemico-biological interactions 2013;203(1):24-9.
2013: Hendra Gunosewoyo; Bhupendra P Doctor; Madhusoodana P Nambiar; Marco Pieroni; Suresh K Tipparaju; Ying Wang; Alan P Kozikowski
Structural analogs of huperzine A improve survival in guinea pigs exposed to soman.
Bioorganic & medicinal chemistry letters 2013;23(5):1544-7.
2012: Michael W Perkins; Zdenka Pierre; Praveena Sabnekar; Alfred M Sciuto; Jian Song; Iswarduth Soojhawon; Bhupendra P Doctor; Samuel Oguntayo; Madhusoodana P Nambiar
Aerosolized delivery of oxime MMB-4 in combination with atropine sulfate protects against soman exposure in guinea pigs.
Inhalation toxicology 2012;24(9):539-49.
2012: Nahum Allon; Carolyn Chambers; Ashima Saxena; Bhupendra P Doctor
A new liposome-based gene delivery system targeting lung epithelial cells using endothelin antagonist.
Journal of controlled release : official journal of the Controlled Release Society 2012;160(2):217-24.
2012: Todd M Myers; Ramachandra S Naik; Matthew G Clark; Bhupendra P Doctor; Wei Sun; Ashima Saxena
Characterization of human serum butyrylcholinesterase in rhesus monkeys: behavioral and physiological effects.
Neurotoxicology and teratology 2012;34(3):323-30.
2012: Magnus M Che; Bhupendra P Doctor; Samuel Oguntayo; Michael W Perkins; Peter Rezk; Alfred M Sciuto; Jian Song; Madhusoodana P Nambiar
Treatment with endotracheal therapeutics after sarin microinstillation inhalation exposure increases blood cholinesterase levels in guinea pigs.
Toxicology mechanisms and methods 2012;22(4):250-9.
2012: Manojkumar Valiyaveettil; Yonas A Alamneh; Bhupendra P Doctor; Madhusoodana P Nambiar
Crossroads in the evaluation of paraoxonase 1 for protection against nerve agent and organophosphate toxicity.
Toxicology letters 2012;210(1):87-94.
2012: Ying Wang; Yanling Wei; Elisa Wood; Samuel Oguntayo; James Auta; Ammon Brown; Bhupendra P Doctor; Alessandro Guiodotti; Neil Jensen; Madhusoodana P Nambiar
Neuroprotective effects of imidazenil against chemical warfare nerve agent soman toxicity in guinea pigs.
Neurotoxicology 2012;33(2):169-77.
2011: Ashima Saxena; Wei Sun; Paul A Dabisch; Nicholas B Hastings; Stanley W Hulet; Edward M Jakubowski; Robert J Mioduszewski; Bhupendra P Doctor
Pretreatment with human serum butyrylcholinesterase alone prevents cardiac abnormalities, seizures, and death in Göttingen minipigs exposed to sarin vapor.
Biochemical pharmacology 2011;82(12):1984-93.
2011: Ying Wang; Yanling Wei; Bhupendra P Doctor; Neil Jensen; Samuel Oguntayo; Madhusoodana P Nambiar
[+]-Huperzine A protects against soman toxicity in guinea pigs.
Neurochemical research 2011;36(12):2381-90.
2011: Magnus M Che; Bhupendra P Doctor; Soma Chanda; Michael W Perkins; Peter E Rezk; Praveena Sabnekar; Alfred M Sciuto; Jian Song; Madhusoodana P Nambiar
Aerosolized scopolamine protects against microinstillation inhalation toxicity to sarin in guinea pigs.
Toxicology mechanisms and methods 2011;21(6):463-72.
2011: Manojkumar Valiyaveettil; Yonas Alamneh; Lionel Biggemann; Iswarduth Soojhawon; Heba A Farag; Prashasthi Agrawal; Bhupendra P Doctor; Madhusoodana P Nambiar
In vitro efficacy of paraoxonase 1 from multiple sources against various organophosphates.
Toxicology in vitro : an international journal published in association with BIBRA 2011;25(4):905-13.
2011: Manojkumar Valiyaveettil; Yonas Alamneh; Peter Rezk; Michael W Perkins; Alfred M Sciuto; Bhupendra P Doctor; Madhusoodana P Nambiar
Recombinant paraoxonase 1 protects against sarin and soman toxicity following microinstillation inhalation exposure in guinea pigs.
Toxicology letters 2011;202(3):203-8.
2011: Michael W Perkins; Zdenka Pierre; Peter Rezk; Alfred M Sciuto; Jian Song; Bhupendra P Doctor; Samuel Oguntayo; Madhusoodana P Nambiar
Acute changes in pulmonary function following microinstillation inhalation exposure to soman in nonatropenized guinea pigs.
International journal of toxicology 2011;30(3):348-57.
2011: Manojkumar Valiyaveettil; Yonas Alamneh; Peter Rezk; Lionel Biggemann; Michael W Perkins; Alfred M Sciuto; Bhupendra P Doctor; Madhusoodana P Nambiar
Protective efficacy of catalytic bioscavenger, paraoxonase 1 against sarin and soman exposure in guinea pigs.
Biochemical pharmacology 2011;81(6):800-9.
2011: Michael W Perkins; Zdenka Pierre; Peter Rezk; Jian Song; Seema Marshall; Samuel Oguntayo; Venee Morthole; Alfred M Sciuto; Bhupendra P Doctor; Madhusoodana P Nambiar
Endotracheal aerosolization of atropine sulfate protects against soman-induced acute respiratory toxicity in guinea pigs.
Inhalation toxicology 2011;23(4):182-95.
2011: Ashima Saxena; Wei Sun; James M Fedorko; Irwin Koplovitz; Bhupendra P Doctor
Prophylaxis with human serum butyrylcholinesterase protects guinea pigs exposed to multiple lethal doses of soman or VX.
Biochemical pharmacology 2011;81(1):164-9.
2010: Manojkumar Valiyaveettil; Yonas Alamneh; Lionel Biggemann; Iswarduth Soojhawon; Bhupendra P Doctor; Madhusoodana P Nambiar
Efficient hydrolysis of the chemical warfare nerve agent tabun by recombinant and purified human and rabbit serum paraoxonase 1.
Biochemical and biophysical research communications 2010;403(1):97-102.
2010: Soma Chanda; Jian Song; Peter Rezk; Praveena Sabnekar; Bhupendra P Doctor; Alfred M Sciuto; Madhusoodana P Nambiar
Gastrointestinal acetylcholinesterase activity following endotracheal microinstillation inhalation exposure to sarin in guinea pigs.
Chemico-biological interactions 2010;187(1-3):309-11.
2010: Yvonne J Rosenberg; Ashima Saxena; Wei Sun; Xiaoming Jiang; Nageswararao Chilukuri; Chunjuan Luo; Bhupendra P Doctor; Keunmyoung D Lee
Demonstration of in vivo stability and lack of immunogenicity of a polyethyleneglycol-conjugated recombinant CHO-derived butyrylcholinesterase bioscavenger using a homologous macaque model.
Chemico-biological interactions 2010;187(1-3):279-86.
2010: Michael W Perkins; Zdenka Pierre; Peter Rezk; Praveena Sabnekar; Kareem Kabra; Soma Chanda; Samuel Oguntayo; Alfred M Sciuto; Bhupendra P Doctor; Madhusoodana P Nambiar
Acute respiratory toxicity following inhalation exposure to soman in guinea pigs.
Toxicology and applied pharmacology 2010;245(2):171-8.
2010: Raymond F Genovese; Wei Sun; Christina C Johnson; Robert C diTargiani; Bhupendra P Doctor; Ashima Saxena
Safety of administration of human butyrylcholinesterase and its conjugates with soman or VX in rats.
Basic & clinical pharmacology & toxicology 2010;106(5):428-34.
2010: Todd M Myers; Wei Sun; Ashima Saxena; Bhupendra P Doctor; Andrew J Bonvillain; Matthew G Clark
Systemic administration of the potential countermeasure huperzine reversibly inhibits central and peripheral acetylcholinesterase activity without adverse cognitive-behavioral effects.
Pharmacology, biochemistry, and behavior 2010;94(3):477-81.
2009: Wei Sun; Chunyuan Luo; Ramachandra S Naik; Bhupendra P Doctor; Ashima Saxena
Pharmacokinetics and immunologic consequences of repeated administrations of purified heterologous and homologous butyrylcholinesterase in mice.
Life sciences 2009;85(17-18):657-61.
2009: Magnus M Che; Michele Conti; Soma Chanda; Megan Boylan; Praveena Sabnekar; Peter Rezk; Ethery Amari; Alfred M Sciuto; Richard Gordon; Bhupendra P Doctor; Madhusoodana P Nambiar
Post-exposure treatment with nasal atropine methyl bromide protects against microinstillation inhalation exposure to sarin in guinea pigs.
Toxicology and applied pharmacology 2009;239(3):251-7.
2009: Nageswararao Chilukuri; Ellen G Duysen; Kalpana Parikh; Robert diTargiani; Bhupendra P Doctor; Oksana Lockridge; Ashima Saxena
Adenovirus-transduced human butyrylcholinesterase in mouse blood functions as a bioscavenger of chemical warfare nerve agents.
Molecular pharmacology 2009;76(3):612-7.
2009: Alexandre M Katos; Michele Conti; Theodore S Moran; Thomas W Chon; Richard Gordon; Alfred M Sciuto; Bhupendra P Doctor; Madhusoodana P Nambiar
Acute microinstillation inhalation exposure to soman induces changes in respiratory dynamics and functions in guinea pigs.
Inhalation toxicology 2009;21(7):1-10.
2008: Ashima Saxena; Chunyuan Luo; Bhupendra P Doctor
Developing procedures for the large-scale purification of human serum butyrylcholinesterase.
Protein expression and purification 2008;61(2):191-6.
2008: Wei Sun; Bhupendra P Doctor; David Lenz; Ashima Saxena
Long-term effects of human butyrylcholinesterase pretreatment followed by acute soman challenge in cynomolgus monkeys.
Chemico-biological interactions 2008;175(1-3):428-30.
2008: Nageswararao Chilukuri; Wei Sun; Ramachandra S Naik; Kalpana Parikh; Lin Tang; Bhupendra P Doctor; Ashima Saxena
Effect of polyethylene glycol modification on the circulatory stability and immunogenicity of recombinant human butyrylcholinesterase.
Chemico-biological interactions 2008;175(1-3):255-60.
2008: Ashima Saxena; Wei Sun; Paul A Dabisch; Stanley W Hulet; Nicholas B Hastings; Edward M Jakubowski; Robert J Mioduszewski; Bhupendra P Doctor
Efficacy of human serum butyrylcholinesterase against sarin vapor.
Chemico-biological interactions 2008;175(1-3):267-72.
2008: Brian R Coleman; Ruthie H Ratcliffe; Samuel A Oguntayo; Xuerong Shi; Bhupendra P Doctor; Richard Gordon; Madhusoodana P Nambiar
[+]-Huperzine A treatment protects against N-methyl-D-aspartate-induced seizure/status epilepticus in rats.
Chemico-biological interactions 2008;175(1-3):387-95.
2008: Bhupendra P Doctor; Karl W K Tsim; Nina L Siow
The IXth International Meeting on Cholinesterases, Suzhou, People's Republic of China, 6 to 10 May 2007.
Chemico-biological interactions 2008;175(1-3):1-2.
2008: Julian R Haigh; Scott R Johnston; Adam Peppernay; Patrick J Mattern; Gregory E Garcia; Bhupendra P Doctor; Richard Gordon; Paul S Aisen
Protection of red blood cell acetylcholinesterase by oral huperzine A against ex vivo soman exposure: next generation prophylaxis and sequestering of acetylcholinesterase over butyrylcholinesterase.
Chemico-biological interactions 2008;175(1-3):380-6.
2008: Julian R Haigh; Lee J Lefkowitz; Benedict R Capacio; Bhupendra P Doctor; Richard Gordon
Advantages of the WRAIR whole blood cholinesterase assay: comparative analysis to the micro-Ellman, Test-mate ChE, and Michel (DeltapH) assays.
Chemico-biological interactions 2008;175(1-3):417-20.
2008: Ramachandra S Naik; Bhupendra P Doctor; Ashima Saxena
Comparison of methods used for the determination of cholinesterase activity in whole blood.
Chemico-biological interactions 2008;175(1-3):298-302.
2008: Nageswararao Chilukuri; Ellen G Duysen; Kalpana Parikh; Wei Sun; Bhupendra P Doctor; Oksana Lockridge; Ashima Saxena
Adenovirus-mediated gene transfer of human butyrylcholinesterase results in persistent high-level transgene expression in vivo.
Chemico-biological interactions 2008;175(1-3):327-31.
2008: Nageswararao Chilukuri; Wei Sun; Kalpana Parikh; Ramachandra S Naik; Lin Tang; Bhupendra P Doctor; Ashima Saxena
A repeated injection of polyethyleneglycol-conjugated recombinant human butyrylcholinesterase elicits immune response in mice.
Toxicology and applied pharmacology 2008;231(3):423-9.
2008: Bryan F Curtin; Karthik I Seetharam; Pilin Dhoieam; Richard Gordon; Bhupendra P Doctor; Madhusoodana P Nambiar
Resveratrol induces catalytic bioscavenger paraoxonase 1 expression and protects against chemical warfare nerve agent toxicity in human cell lines.
Journal of cellular biochemistry 2008;103(5):1524-35.
2007: Alexandre M Katos; Michele L Conti; Theodore S Moran; Richard Gordon; Bhupendra P Doctor; Alfred M Sciuto; Madhusoodana P Nambiar
Abdominal bloating and irritable bowel syndrome like symptoms following microinstillation inhalation exposure to chemical warfare nerve agent VX in guinea pigs.
Toxicology and industrial health 2007;23(4):231-40.
2007: Peter E Rezk; Jacob R Graham; Theodore S Moran; Richard Gordon; Alfred M Sciuto; Bhupendra P Doctor; Madhusoodana P Nambiar
Acute toxic effects of nerve agent VX on respiratory dynamics and functions following microinsillation inhalation exposure in guinea pigs.
Inhalation toxicology 2007;19(3):291-302.
2007: Madhusoodana P Nambiar; Richard Gordon; Peter E Rezk; Alexander M Katos; Nikolai A Wajda; Theodore S Moran; Keith E Steele; Bhupendra P Doctor; Alfred M Sciuto
Medical countermeasure against respiratory toxicity and acute lung injury following inhalation exposure to chemical warfare nerve agent VX.
Toxicology and applied pharmacology 2007;219(2-3):142-50.
2006: Ashima Saxena; Wei Sun; Chunyuan Luo; Todd M Myers; Irwin Koplovitz; David Lenz; Bhupendra P Doctor
Bioscavenger for protection from toxicity of organophosphorus compounds.
Journal of molecular neuroscience : MN 2006;30(1-2):145-8.
2006: Praful B Godkar; Richard Gordon; Arippa Ravindran; Bhupendra P Doctor
Celastrus paniculatus seed oil and organic extracts attenuate hydrogen peroxide- and glutamate-induced injury in embryonic rat forebrain neuronal cells.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2006;13(1-2):29-36.
2005: Wei Sun; Bhupendra P Doctor; Ashima Saxena
Safety and pharmacokinetics of human serum butyrylcholinesterase in guinea pigs.
Chemico-biological interactions 2005;157-158():428-9.
2005: Laura S Tonduli; Bhupendra P Doctor; Ashima Saxena
An ex vivo approach for the evaluation of reversible inhibitors as potential pretreatments against organophosphate toxicity.
Chemico-biological interactions 2005;157-158():426-7.
2005: Chunyuan Luo; Maureen Dawson; Carolyn Chambers; Nageswararao Chilukuri; Zoran Radić; Palmer Taylor; Bhupendra P Doctor; Ashima Saxena
Species-related differences in the oxime-induced reactivation of organophosphate-inhibited acetylcholinesterases.
Chemico-biological interactions 2005;157-158():393-4.
2005: Julian R Haigh; Scott R Johnston; Brian M Peters; Bhupendra P Doctor; Richard Gordon; Michael Adler; Kenneth J Gall; Sharad S Deshpande
Inhibition of guinea pig hemi-diaphragm acetylcholinesterase activity by pyridostigmine bromide and protection against soman toxicity.
Chemico-biological interactions 2005;157-158():381-2.
2005: Madhusoodana P Nambiar; Bryan F Curtin; Nabaneeta Pal; J R Compton; Bhupendra P Doctor; Richard Gordon
Transcriptional induction of cholinesterase expression and protection against chemical warfare nerve agents.
Chemico-biological interactions 2005;157-158():409-10.
2005: david e lenz; E M Griffiths; Bhupendra P Doctor; Ashima Saxena; James M Fedorko; N H Greig; Q S Yu; Y Huang; Harvey Wilgus; Costas N Karatzas; Irwin Koplovitz; David Lenz
In vitro and in vivo characterization of recombinant human butyrylcholinesterase (Protexia) as a potential nerve agent bioscavenger.
Chemico-biological interactions 2005;157-158():363-5.
2005: Bhupendra P Doctor; Ashima Saxena
Bioscavengers for the protection of humans against organophosphate toxicity.
Chemico-biological interactions 2005;157-158():167-71.
2005: David Lenz; Donald M Maxwell; Irwin Koplovitz; Connie R Clark; Benjamin R Capacio; david e lenz; James M Federko; Chunyuan Luo; Ashima Saxena; Bhupendra P Doctor; Carl Olson
Protection against soman or VX poisoning by human butyrylcholinesterase in guinea pigs and cynomolgus monkeys.
Chemico-biological interactions 2005;157-158():205-10.
2005: Ashima Saxena; Wei Sun; Chunyuan Luo; Bhupendra P Doctor
Human serum butyrylcholinesterase: in vitro and in vivo stability, pharmacokinetics, and safety in mice.
Chemico-biological interactions 2005;157-158():199-203.
2005: Richard Gordon; Julian R Haigh; Gregory E Garcia; Shawn R Feaster; Michael A Riel; David Lenz; Paul S Aisen; Bhupendra P Doctor
Oral administration of pyridostigmine bromide and huperzine A protects human whole blood cholinesterases from ex vivo exposure to soman.
Chemico-biological interactions 2005;157-158():239-46.
2005: Nageswararao Chilukuri; K Parikh; Wei Sun; R Naik; P Tipparaju; Bhupendra P Doctor; Ashima Saxena
Polyethylene glycosylation prolongs the circulatory stability of recombinant human butyrylcholinesterase.
Chemico-biological interactions 2005;157-158():115-21.
2005: Bryan F Curtin; Lauren M Tetz; Jaimee R Compton; Bhupendra P Doctor; Richard Gordon; Madhusoodana P Nambiar
Histone acetylase inhibitor trichostatin A induces acetylcholinesterase expression and protects against organophosphate exposure.
Journal of cellular biochemistry 2005;96(4):839-49.
2005: Matthew G Clark; Wei Sun; Todd M Myers; Reeta Bansal; Bhupendra P Doctor; Ashima Saxena
Effects of physostigmine and human butyrylcholinesterase on acoustic startle reflex and prepulse inhibition in C57BL/6J mice.
Pharmacology, biochemistry, and behavior 2005;81(3):497-505.
2004: Praful B Godkar; Richard Gordon; Arippa Ravindran; Bhupendra P Doctor
Celastrus paniculatus seed water soluble extracts protect against glutamate toxicity in neuronal cultures from rat forebrain.
Journal of ethnopharmacology 2004;93(2-3):213-9.
2004: Gregory E Garcia; Rickey P Hicks; David J Skanchy; Deborah R Moorad-Doctor; Bhupendra P Doctor; Haresh S Ved
Identification and characterization of the major huperzine a metabolite in rat blood.
Journal of analytical toxicology 2004;28(5):379-83.
2004: Lucie Sevelová; Jiri Bajgar; Ashima Saxena; Bhupendra P Doctor
Protective effect of equine butyrylcholinesterase in inhalation intoxication of rats with sarin: determination of blood and brain cholinesterase activities.
Inhalation toxicology 2004;16(8):531-6.
2003: Ashima Saxena; Regina S Hur; Chunyuan Luo; Bhupendra P Doctor
Natural monomeric form of fetal bovine serum acetylcholinesterase lacks the C-terminal tetramerization domain.
Biochemistry 2003;42(51):15292-9.
2003: Praful B Godkar; Richard Gordon; Arippa Ravindran; Bhupendra P Doctor
Celastrus paniculatus seed water soluble extracts protect cultured rat forebrain neuronal cells from hydrogen peroxide-induced oxidative injury.
Fitoterapia 2003;74(7-8):658-69.
2003: Ashima Saxena; James M Fedorko; C R Vinayaka; Rohit Medhekar; Zoran Radić; Palmer Taylor; Oksana Lockridge; Bhupendra P Doctor
Aromatic amino-acid residues at the active and peripheral anionic sites control the binding of E2020 (Aricept) to cholinesterases.
European journal of biochemistry / FEBS 2003;270(22):4447-58.
2003: Chunyuan Luo; Haim Leader; Zoran Radic; Donald M Maxwell; Palmer Taylor; Bhupendra P Doctor; Ashima Saxena
Two possible orientations of the HI-6 molecule in the reactivation of organophosphate-inhibited acetylcholinesterase.
Biochemical pharmacology 2003;66(3):387-92.
2003: Yacov Ashani; Apurba K Bhattacharjee; Haim Leader; Ashima Saxena; Bhupendra P Doctor
Inhibition of cholinesterases with cationic phosphonyl oximes highlights distinctive properties of the charged pyridine groups of quaternary oxime reactivators.
Biochemical pharmacology 2003;66(2):191-202.
2002: Yvonne Rosenberg; Chunyuan Luo; Yacov Ashani; Bhupendra P Doctor; Randy Fischer; Gary Wolfe; Ashima Saxena
Pharmacokinetics and immunologic consequences of exposing macaques to purified homologous butyrylcholinesterase.
Life sciences 2002;72(2):125-34.
2002: V Rajendran; Ashima Saxena; Bhupendra P Doctor; Alan P Kozikowski
Synthesis of more potent analogues of the acetylcholinesterase inhibitor, huperzine B.
Bioorganic & medicinal chemistry letters 2002;12(11):1521-3.
2001: Richard Gordon; S V Nigam; J A Weitz; Jitendra R Dave; Bhupendra P Doctor; Haresh S Ved
The NMDA receptor ion channel: a site for binding of Huperzine A.
Journal of applied toxicology : JAT 2001;21 Suppl 1():S47-51.
2000: V Rajendran; KR Prakash; Haresh S Ved; A Saxena; Bhupendra P Doctor; Alan P Kozikowski
Synthesis, chiral chromatographic separation, and biological activities of the enantiomers of 10,10-dimethylhuperzine A.
Bioorganic & medicinal chemistry letters 2000;10(21):2467-9.
1999: Chunyuan Luo; Ashima Saxena; M Smith; G Garcia; Z Radić; Palmer Taylor; Bhupendra P Doctor
Phosphoryl oxime inhibition of acetylcholinesterase during oxime reactivation is prevented by edrophonium.
Biochemistry 1999;38(31):9937-47.
1999: Richard Gordon; Shawn R Feaster; Alan Russell; KE LeJeune; david e lenz; David Lenz; M Ross; Bhupendra P Doctor
Organophosphate skin decontamination using immobilized enzymes.
Chemico-biological interactions 1999;119-120():463-70.
1999: Donald M Maxwell; A Saxena; Richard Gordon; Bhupendra P Doctor
Improvements in scavenger protection against organophosphorus agents by modification of cholinesterases.
Chemico-biological interactions 1999;119-120():419-28.
1999: Chunyuan Luo; Ashima Saxena; Yacov Ashani; Haim Leader; Z Radić; Palmer Taylor; Bhupendra P Doctor
Role of edrophonium in prevention of the re-inhibition of acetylcholinesterase by phosphorylated oxime.
Chemico-biological interactions 1999;119-120():129-35.
1999: Ashima Saxena; A M Redman; X Jiang; Oksana Lockridge; Bhupendra P Doctor
Differences in active-site gorge dimensions of cholinesterases revealed by binding of inhibitors to human butyrylcholinesterase.
Chemico-biological interactions 1999;119-120():61-9.
1998: KE LeJeune; BC Dravis; F Yang; A D Hetro; Bhupendra P Doctor; Alan Russell
Fighting nerve agent chemical weapons with enzyme technology.
Annals of the New York Academy of Sciences 1998;864():153-70.
1998: Ashima Saxena; Carol Viragh; D S Frazier; Ildiko M Kovach; Donald M Maxwell; Oksana Lockridge; Bhupendra P Doctor
The pH dependence of dealkylation in soman-inhibited cholinesterases and their mutants: further evidence for a push-pull mechanism.
Biochemistry 1998;37(43):15086-96.
1998: Gil Amitai; D Moorad; Rellie Adani; Bhupendra P Doctor
Inhibition of acetylcholinesterase and butyrylcholinesterase by chlorpyrifos-oxon.
Biochemical pharmacology 1998;56(3):293-9.
1998: Chunyuan Luo; Yacov Ashani; Bhupendra P Doctor
Acceleration of oxime-induced reactivation of organophosphate-inhibited fetal bovine serum acetylcholinesterase by monoquaternary and bisquaternary ligands.
Molecular pharmacology 1998;53(4):718-26.
1998: Ashima Saxena; R Hur; Bhupendra P Doctor
Allosteric control of acetylcholinesterase activity by monoclonal antibodies.
Biochemistry 1998;37(1):145-54.
1998: Ashima Saxena; Yacov Ashani; Lily Raveh; D Stevenson; T Patel; Bhupendra P Doctor
Role of oligosaccharides in the pharmacokinetics of tissue-derived and genetically engineered cholinesterases.
Molecular pharmacology 1998;53(1):112-22.
1997: Ashima Saxena; A M Redman; X Jiang; Oksana Lockridge; Bhupendra P Doctor
Differences in active site gorge dimensions of cholinesterases revealed by binding of inhibitors to human butyrylcholinesterase.
Biochemistry 1997;36(48):14642-51.
1997: Ashima Saxena; Donald M Maxwell; Daniel M Quinn; Z Radić; Palmer Taylor; Bhupendra P Doctor
Mutant acetylcholinesterases as potential detoxification agents for organophosphate poisoning.
Biochemical pharmacology 1997;54(2):269-74.
1997: Ashima Saxena; Lily Raveh; Yacov Ashani; Bhupendra P Doctor
Structure of glycan moieties responsible for the extended circulatory life time of fetal bovine serum acetylcholinesterase and equine serum butyrylcholinesterase.
Biochemistry 1997;36(24):7481-9.
1997: Haresh S Ved; Michael L Koenig; Jitendra R Dave; Bhupendra P Doctor
Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamate.
Neuroreport 1997;8(4):963-8.
1997: Jitendra R Dave; Michael L Koenig; Frank C Tortella; R A Pieringer; Bhupendra P Doctor; Haresh S Ved
Dodecylglycerol provides partial protection against glutamate toxicity in neuronal cultures derived from different regions of embryonic rat brain.
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid 1997;30(1-2):1-13.
1997: Raymond F Genovese; Bhupendra P Doctor
Behavioral comparison of the oximes TMB-4, 2-PAM, and HI-6 in rats using operant conditioning.
Pharmacology, biochemistry, and behavior 1997;56(1):139-43.
1996: P K Chiang; Richard Gordon; J Tal; G C Zeng; Bhupendra P Doctor; K Pardhasaradhi; P P McCann
S-Adenosylmethionine and methylation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(4):471-80.
1995: Zoran Grubic; Anton Stalc; Marjeta Sentjurc; Slavko Pecar; M K Gentry; Bhupendra P Doctor
Different effects of two peripheral anionic site-binding ligands on acetylcholinesterase active-site gorge topography revealed by electron paramagnetic resonance.
Biochimica et biophysica acta 1995;1249(2):155-60.
1995: Yacov Ashani; Z Radić; Igor Tsigelny; D C Vellom; N A Pickering; Daniel M Quinn; Bhupendra P Doctor; Palmer Taylor
Amino acid residues controlling reactivation of organophosphonyl conjugates of acetylcholinesterase by mono- and bisquaternary oximes.
The Journal of biological chemistry 1995;270(11):6370-80.
1995: M K Gentry; D R Moorad; R S Hur; Ashima Saxena; Yacov Ashani; Bhupendra P Doctor
Characterization of monoclonal antibodies that inhibit the catalytic activity of acetylcholinesterases.
Journal of neurochemistry 1995;64(2):842-9.
1995: D L Mayers; J A Mikovits; B Joshi; I K Hewlett; J S Estrada; A D Wolfe; G E Garcia; Bhupendra P Doctor; Donald S. Burke; Richard Gordon
Anti-human immunodeficiency virus 1 (HIV-1) activities of 3-deazaadenosine analogs: increased potency against 3'-azido-3'-deoxythymidine-resistant HIV-1 strains.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(1):215-9.
1994: Ashima Saxena; N Qian; Ildiko M Kovach; Alan P Kozikowski; Y P Pang; D C Vellom; Z Radić; Daniel M Quinn; Palmer Taylor; Bhupendra P Doctor
Identification of amino acid residues involved in the binding of Huperzine A to cholinesterases.
Protein science : a publication of the Protein Society 1994;3(10):1770-8.
1994: J Grunwald; Lily Raveh; Bhupendra P Doctor; Yacov Ashani
Huperzine A as a pretreatment candidate drug against nerve agent toxicity.
Life sciences 1994;54(14):991-7.
1993: Yoffi Segall; D Waysbort; Dov Barak; Naomi Ariel; Bhupendra P Doctor; J Grunwald; Yacov Ashani
Direct observation and elucidation of the structures of aged and nonaged phosphorylated cholinesterases by 31P NMR spectroscopy.
Biochemistry 1993;32(49):13441-50.
1993: A D Wolfe; P K Chiang; Bhupendra P Doctor; N Fryar; J P Rhee; M Saeed
Monoclonal antibody AE-2 modulates carbamate and organophosphate inhibition of fetal bovine serum acetylcholinesterase.
Molecular pharmacology 1993;44(6):1152-7.
1993: L Wasserman; Bhupendra P Doctor; M K Gentry; Palmer Taylor
Epitope mapping of form-specific and nonspecific antibodies to acetylcholinesterase.
Journal of neurochemistry 1993;61(6):2124-32.
1993: Ashima Saxena; Bhupendra P Doctor; david e lenz; David Lenz; Zoran Radic; Palmer Taylor
The role of glutamate-199 in the aging of cholinesterase.
Biochemical and biophysical research communications 1993;197(1):343-9.
1993: Bhupendra P Doctor; Dennis W Blick; G Caranto; C A Castro; M K Gentry; R Larrison; Donald M Maxwell; M R Murphy; M Schutz; K Waibel
Cholinesterases as scavengers for organophosphorus compounds: protection of primate performance against soman toxicity.
Chemico-biological interactions 1993;87(1-3):285-93.
1993: M K Gentry; Ashima Saxena; Yacov Ashani; Bhupendra P Doctor
Immunochemical characterization of anti-acetylcholinesterase inhibitory monoclonal antibodies.
Chemico-biological interactions 1993;87(1-3):227-31.
1993: Miroslaw Cygler; Joseph D Schrag; Joel Sussman; Michal Harel; Israel Silman; M K Gentry; Bhupendra P Doctor
Relationship between sequence conservation and three-dimensional structure in a large family of esterases, lipases, and related proteins.
Protein science : a publication of the Protein Society 1993;2(3):366-82.
1993: Donald M Maxwell; K M Brecht; Bhupendra P Doctor; A D Wolfe
Comparison of antidote protection against soman by pyridostigmine, HI-6 and acetylcholinesterase.
The Journal of pharmacology and experimental therapeutics 1993;264(3):1085-9.
1992: H F Elson; M K Gentry; Bhupendra P Doctor
Membrane-bound acetylcholinesterase: an early differentiation marker for skeletal myoblasts.
Biochimica et biophysica acta 1992;1156(1):78-84.
1992: A D Wolfe; Dennis W Blick; M R Murphy; S A Miller; M K Gentry; S L Hartgraves; Bhupendra P Doctor
Use of cholinesterases as pretreatment drugs for the protection of rhesus monkeys against soman toxicity.
Toxicology and applied pharmacology 1992;117(2):189-93.
1992: Donald M Maxwell; C A Castro; D M De La Hoz; M K Gentry; M B Gold; R P Solana; A D Wolfe; Bhupendra P Doctor
Protection of rhesus monkeys against soman and prevention of performance decrement by pretreatment with acetylcholinesterase.
Toxicology and applied pharmacology 1992;115(1):44-9.
1992: Yacov Ashani; J O Peggins; Bhupendra P Doctor
Mechanism of inhibition of cholinesterases by huperzine A.
Biochemical and biophysical research communications 1992;184(2):719-26.
1992: H F Elson; M K Gentry; Bhupendra P Doctor
A microtiter assay for determining protein, acetylcholinesterase activity, and G418 (Neomycin) resistance in cultured cells.
Analytical biochemistry 1992;200(2):268-72.
1992: P K Chiang; J Katzhendler; Richard Gordon; Bhupendra P Doctor; N D Brown
Postganglionic nicotinic action of anatoxin-a on guinea pig ileum antagonized by thymopentin.
Advances in experimental medicine and biology 1992;311():429-30.
1991: Bhupendra P Doctor; Lily Raveh; A D Wolfe; Donald M Maxwell; Yacov Ashani
Enzymes as pretreatment drugs for organophosphate toxicity.
Neuroscience and biobehavioral reviews 1991;15(1):123-8.
1991: Yacov Ashani; S Shapira; D Levy; A D Wolfe; Bhupendra P Doctor; Lily Raveh
Butyrylcholinesterase and acetylcholinesterase prophylaxis against soman poisoning in mice.
Biochemical pharmacology 1991;41(1):37-41.
1990: R A Ogert; M K Gentry; E C Richardson; C D Deal; S N Abramson; C R Alving; Palmer Taylor; Bhupendra P Doctor
Studies on the topography of the catalytic site of acetylcholinesterase using polyclonal and monoclonal antibodies.
Journal of neurochemistry 1990;55(3):756-63.
1990: Bhupendra P Doctor; T C Chapman; C E Christner; C D Deal; D M De La Hoz; M K Gentry; R A Ogert; R S Rush; K K Smyth; A D Wolfe
Complete amino acid sequence of fetal bovine serum acetylcholinesterase and its comparison in various regions with other cholinesterases.
FEBS letters 1990;266(1-2):123-7.
1990: Yacov Ashani; M K Gentry; Bhupendra P Doctor
Differences in conformational stability between native and phosphorylated acetylcholinesterase as evidenced by a monoclonal antibody.
Biochemistry 1990;29(10):2456-63.
1989: Haim Leader; R M Smejkal; C S Payne; F N Padilla; Bhupendra P Doctor; Richard Gordon; P K Chiang
Binary antidotes for organophosphate poisoning: aprophen analogues that are both antimuscarinics and carbamates.
Journal of medicinal chemistry 1989;32(7):1522-8.
1989: S N Abramson; Mark H Ellisman; Thomas J Deerinck; Y Maulet; M K Gentry; Bhupendra P Doctor; Palmer Taylor
Differences in structure and distribution of the molecular forms of acetylcholinesterase.
The Journal of cell biology 1989;108(6):2301-11.
1989: Lily Raveh; Yacov Ashani; D Levy; D De La Hoz; A D Wolfe; Bhupendra P Doctor
Acetylcholinesterase prophylaxis against organophosphate poisoning. Quantitative correlation between protection and blood-enzyme level in mice.
Biochemical pharmacology 1989;38(3):529-34.
1989: Bhupendra P Doctor; K K Smyth; M K Gentry; Yacov Ashani; C E Christner; D M de la Hoz; R A Ogert; S W Smith
Structural and immunochemical properties of fetal bovine serum acetylcholinesterase.
Progress in clinical and biological research 1989;289():305-16.
1988: N D Brown; R M Smejkal; E Breuer; Bhupendra P Doctor; P K Chiang
Desethylaprophen: a metabolite of aprophen with antimuscarinic activities.
Journal of pharmaceutical sciences 1988;77(2):145-8.
1987: A D Wolfe; R S Rush; Bhupendra P Doctor; I Koplovitz; D Jones
Acetylcholinesterase prophylaxis against organophosphate toxicity.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1987;9(2):266-70.
1986: R S Rush; Bhupendra P Doctor; A D Wolfe
Kinetic investigations into the interactions of aprophen with cholinesterases and a carboxylesterase.
Biochemical pharmacology 1986;35(23):4167-70.
1986: Jarle Aarbakke; G A Miura; N D Brown; R R Gray; Richard Gordon; Bhupendra P Doctor; P K Chiang
Disposition of aprophen in rats.
The Journal of pharmacy and pharmacology 1986;38(12):928-30.
1986: D De la Hoz; Bhupendra P Doctor; J S Ralston; R S Rush; A D Wolfe
A simplified procedure for the purification of large quantities of fetal bovine serum acetylcholinesterase.
Life sciences 1986;39(3):195-9.
1986: G A Miura; P K Chiang; Richard Gordon; Bhupendra P Doctor; C E Twine; A Philip; J A Kepler; F I Carroll
Enzymatic synthesis of a false cholinergic neurotransmitter: diethylaminoethyl acetate as a muscarinic agonist analog of acetylcholine.
General pharmacology 1986;17(4):477-80.
1985: J S Ralston; R S Rush; Bhupendra P Doctor; A D Wolfe
Acetylcholinesterase from fetal bovine serum. Purification and characterization of soluble G4 enzyme.
The Journal of biological chemistry 1985;260(7):4312-8.
1984: N D Brown; R R Gray; M G Stermer-Cox; Bhupendra P Doctor; I Hagedorn
Stability study of HI-6 dichloride in various anticholinergic formulations.
Journal of chromatography 1984;315():389-94.
1983: Richard Gordon; F N Padilla; E Moore; Bhupendra P Doctor; P K Chiang
Antimuscarinic activity of aprophen.
Biochemical pharmacology 1983;32(19):2979-81.
1983: Bhupendra P Doctor; S Camp; M K Gentry; S S Taylor; P Taylor
Antigenic and structural differences in the catalytic subunits of the molecular forms of acetylcholinesterase.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(18):5767-71.
1982: Richard Gordon; Bhupendra P Doctor; P K Chiang
A radioactive assay for acetylcholinesterase using anion-exchange disk.
Analytical biochemistry 1982;124(2):333-7.