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Jeffrey Dodge

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Jun Zhang; Michael J Chalmers; Keith R Stayrook; Lorri L Burris; Yongjun Wang; Scott A Busby; Bruce Pascal; Ruben D Garcia-Ordonez; John B Bruning; Monica A Istrate; Douglas J Kojetin; Jeffrey A Dodge; Burris thomas; Patrick R Griffin
DNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex.
Jun Zhang; Michael J Chalmers; Keith R Stayrook; Lorri L Burris; Ruben D Garcia-Ordonez; Bruce Pascal; Thomas P Burris; Jeffrey A Dodge; Patrick R Griffin
Hydrogen/deuterium exchange reveals distinct agonist/partial agonist receptor dynamics within vitamin D receptor/retinoid X receptor heterodimer.
Susie Y Dai; Thomas P Burris; Jeffrey A Dodge; Chahrzad Montrose-Rafizadeh; Yong Wang; Bruce Pascal; Michael J Chalmers; Patrick R Griffin
Unique ligand binding patterns between estrogen receptor alpha and beta revealed by hydrogen-deuterium exchange.

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2011: Jun Zhang; Michael J Chalmers; Keith R Stayrook; Lorri L Burris; Yongjun Wang; Scott A Busby; Bruce Pascal; Ruben D Garcia-Ordonez; John B Bruning; Monica A Istrate; Douglas J Kojetin; Jeffrey A Dodge; Burris thomas; Patrick R Griffin
DNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex.
Nature structural & molecular biology 2011;18(5):556-63.
2010: Jun Zhang; Michael J Chalmers; Keith R Stayrook; Lorri L Burris; Ruben D Garcia-Ordonez; Bruce Pascal; Thomas P Burris; Jeffrey A Dodge; Patrick R Griffin
Hydrogen/deuterium exchange reveals distinct agonist/partial agonist receptor dynamics within vitamin D receptor/retinoid X receptor heterodimer.
Structure (London, England : 1993) 2010;18(10):1332-41.
2009: Susie Y Dai; Thomas P Burris; Jeffrey A Dodge; Chahrzad Montrose-Rafizadeh; Yong Wang; Bruce Pascal; Michael J Chalmers; Patrick R Griffin
Unique ligand binding patterns between estrogen receptor alpha and beta revealed by hydrogen-deuterium exchange.
Biochemistry 2009;48(40):9668-76.
2007: Timothy I Richardson; Jeffrey A Dodge; Yong Wang; Jim D Durbin; Venkatesh Krishnan; Bryan H Norman
Benzopyrans as selective estrogen receptor beta agonists (SERBAs). Part 5: Combined A- and C-ring structure-activity relationship studies.
Bioorganic & medicinal chemistry letters 2007;17(20):5563-6.
2007: Bryan H Norman; Timothy I Richardson; Jeffrey A Dodge; Lance A Pfeifer; Gregory L Durst; Yong Wang; Jim D Durbin; Venkatesh Krishnan; Sean R Dinn; Shengquan Liu; John E Reilly; Kendal T Ryter
Benzopyrans as selective estrogen receptor beta agonists (SERBAs). Part 4: functionalization of the benzopyran A-ring.
Bioorganic & medicinal chemistry letters 2007;17(18):5082-5.
2007: Timothy I Richardson; Jeffrey A Dodge; Gregory L Durst; Lance A Pfeifer; Jikesh Shah; Yong Wang; Jim D Durbin; Venkatesh Krishnan; Bryan H Norman
Benzopyrans as selective estrogen receptor beta agonists (SERBAs). Part 3: synthesis of cyclopentanone and cyclohexanone intermediates for C-ring modification.
Bioorganic & medicinal chemistry letters 2007;17(17):4824-8.
2007: Timothy I Richardson; Bryan H Norman; Charles W Lugar; Scott A Jones; Yong Wang; Jim D Durbin; Venkatesh Krishnan; Jeffrey A Dodge
Benzopyrans as selective estrogen receptor beta agonists (SERBAs). Part 2: structure-activity relationship studies on the benzopyran scaffold.
Bioorganic & medicinal chemistry letters 2007;17(13):3570-4.
2007: Timothy I Richardson; Scott A Frank; minmin wang; Christian A Clarke; Scott A Jones; Bai-Ping Ying; Dan T Kohlman; Owen B Wallace; Timothy A Shepherd; Robert D Dally; Alan D Palkowitz; Andrew G Geiser; Henry Bryant; Judith W Henck; Ilene R Cohen; Daniel G Rudmann; Denis J McCann; David E Coutant; Samuel W Oldham; Conrad W Hummel; Kin C Fong; Ronald Hinklin; George Lewis; Hongqi Tian; Jeffrey A Dodge
Structure-activity relationships of SERMs optimized for uterine antagonism and ovarian safety.
Bioorganic & medicinal chemistry letters 2007;17(13):3544-9.
2006: Bryan H Norman; Jeffrey A Dodge; Timothy I Richardson; Peter S Borromeo; Charles W Lugar; Scott A Jones; Keyue Chen; Yong Wang; Gregory L Durst; Robert J Barr; Chahrzad Montrose-Rafizadeh; Harold E Osborne; Robert M Amos; Sherry Guo; Amechand Boodhoo; Venkatesh Krishnan
Benzopyrans are selective estrogen receptor beta agonists with novel activity in models of benign prostatic hyperplasia.
Journal of medicinal chemistry 2006;49(21):6155-7.
2006: Owen B Wallace; Kenneth S Lauwers; Jeffrey A Dodge; Scott A May; Joel R Calvin; Ronald Hinklin; Henry Bryant; Pamela K Shetler; Mary D Adrian; Andrew G Geiser; Masahiko Sato; Burris thomas
A selective estrogen receptor modulator for the treatment of hot flushes.
Journal of medicinal chemistry 2006;49(3):843-6.
2005: Conrad W Hummel; Andrew G Geiser; Henry Bryant; Ilene R Cohen; Robert D Dally; Kin Chiu Fong; Scott A Frank; Ronald Hinklin; Scott A Jones; George Lewis; Denis J McCann; Daniel G Rudmann; Timothy A Shepherd; Hongqi Tian; Owen B Wallace; minmin wang; Yong Wang; Jeffrey A Dodge
A selective estrogen receptor modulator designed for the treatment of uterine leiomyoma with unique tissue specificity for uterus and ovaries in rats.
Journal of medicinal chemistry 2005;48(22):6772-5.
2005: Andrew G Geiser; Conrad W Hummel; Michael W Draper; Judith W Henck; Ilene R Cohen; Daniel G Rudmann; Kevin B Donnelly; Mary D Adrian; Timothy A Shepherd; Owen B Wallace; Denis J McCann; Samuel W Oldham; Henry Bryant; Masahiko Sato; Jeffrey A Dodge
A new selective estrogen receptor modulator with potent uterine antagonist activity, agonist activity in bone, and minimal ovarian stimulation.
Endocrinology 2005;146(10):4524-35.
2005: Leah M Helvering; Mary D Adrian; Andrew G Geiser; Shawn T Estrem; Tao Wei; Shuguang Huang; Peining Chen; Ernst Dow; J N Calley; Jeffrey A Dodge; Timothy Grese; Scott A Jones; David L Halladay; Rebecca R Miles; Jude E Onyia; Yanfei L Ma; Masahiko Sato; Henry Bryant
Differential effects of estrogen and raloxifene on messenger RNA and matrix metalloproteinase 2 activity in the rat uterus.
Biology of reproduction 2005;72(4):830-41.
2005: Venkatesh Krishnan; H A Bullock; Benjamin C Yaden; M Liu; Robert J Barr; Chahrzad Montrose-Rafizadeh; K Chen; Jeffrey A Dodge; Henry Bryant
The nongenotropic synthetic ligand 4-estren-3alpha17beta-diol is a high-affinity genotropic androgen receptor agonist.
Molecular pharmacology 2005;67(3):744-8.
2004: Charles W Lugar; Michael P Clay; Terry D Lindstrom; Andrea L Woodson; David L Smiley; Mark L Heiman; Jeffrey A Dodge
Synthesis and biological evaluation of an orally active ghrelin agonist that stimulates food consumption and adiposity in rats.
Bioorganic & medicinal chemistry letters 2004;14(23):5873-6.
2003: Charles W Lugar; David Magee; Mary D Adrian; Pamela K Shetler; Henry Bryant; Jeffrey A Dodge
B-ring unsaturated estrogens: biological evaluation of 17alpha-Dihydroequilein and novel B-Nor-6-thiaequilenins as tissue selective estrogens.
Bioorganic & medicinal chemistry letters 2003;13(24):4281-4.
2003: Owen B Wallace; Kenneth S Lauwers; Scott A Jones; Jeffrey A Dodge
Tetrahydroquinoline-based selective estrogen receptor modulators (SERMs).
Bioorganic & medicinal chemistry letters 2003;13(11):1907-10.
2003: Owen B Wallace; Timothy I Richardson; Jeffrey A Dodge
Estrogen receptor modulators: relationships of ligand structure, receptor affinity and functional activity.
Current topics in medicinal chemistry 2003;3(14):1663-82.
2000: joseph kennedy; J L Bowers; Jeffrey A Dodge; Charles W Lugar; Timothy A Shepherd; V Scott Sharp
Development of analytical and preparative chromatographic separations of novel growth hormone secretagogue compounds.
Journal of chromatography. A 2000;872(1-2):75-84.
1999: Masahiko Sato; Timothy Grese; Jeffrey A Dodge; Henry Bryant; C H Turner
Emerging therapies for the prevention or treatment of postmenopausal osteoporosis.
Journal of medicinal chemistry 1999;42(1):1-24.
1998: Timothy Grese; Jeffrey A Dodge
Selective estrogen receptor modulators (SERMs).
Current pharmaceutical design 1998;4(1):71-92.
1997: Timothy Grese; James Sluka; Henry Bryant; GJ Cullinan; Andrew Glasebrook; C D Jones; K Matsumoto; Alan D Palkowitz; Masahiko Sato; J D Termine; Mark A Winter; NN Yang; Jeffrey A Dodge
Molecular determinants of tissue selectivity in estrogen receptor modulators.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):14105-10.
1997: Jeffrey A Dodge; Charles W Lugar; S Cho; LL Short; Masahiko Sato; NN Yang; LA Spangle; M J Martin; DL Phillips; Andrew Glasebrook; J J Osborne; Charles A Frolik; Henry Bryant
Evaluation of the major metabolites of raloxifene as modulators of tissue selectivity.
The Journal of steroid biochemistry and molecular biology 1997;61(1-2):97-106.
1996: Jeffrey A Dodge; Andrew Glasebrook; David Magee; DL Phillips; Masahiko Sato; LL Short; Henry Bryant
Environmental estrogens: effects on cholesterol lowering and bone in the ovariectomized rat.
The Journal of steroid biochemistry and molecular biology 1996;59(2):155-61.