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Elizabeth Doherty

Research Profile

Anatomy

CHO Cells

Concepts & Ideas

Chemicals & Drugs

Living Beings

Disorders

Hyperalgesia

Procedures

Administration, Oral

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Publications

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Bin Wu; Hui-Ling Wang; Liping Pettus; Ryan P Wurz; Elizabeth M Doherty; Bradley Henkle; Helen J McBride; Christiaan J M Saris; Lu Min Wong; Matthew H Plant; Lisa Sherman; Matthew R Lee; Faye Hsieh; Andrew S Tasker
Discovery of pyridazinopyridinones as potent and selective p38 mitogen-activated protein kinase inhibitors.
Vijay K Gore; Vu V Ma; Ruoyuan Yin; Joe Ligutti; David Immke; Elizabeth M Doherty; Mark H Norman
Structure-activity relationship (SAR) investigations of tetrahydroquinolines as BKCa agonists.
Adrian L Smith; Frenel F DeMorin; Nick A Paras; Qi Huang; Jeffrey K Petkus; Elizabeth M Doherty; Thomas Nixey; Joseph L Kim; Douglas A Whittington; Linda F Epstein; Matthew R Lee; Mark J Rose; Carol Babij; Manory Fernando; Kristen Hess; Quynh Le; Pedro Beltran; Josette Carnahan
Selective inhibitors of the mutant B-Raf pathway: discovery of a potent and orally bioavailable aminoisoquinoline.

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All Publications

2010: Bin Wu; Hui-Ling Wang; Liping Pettus; Ryan P Wurz; Elizabeth M Doherty; Bradley Henkle; Helen J McBride; Christiaan J M Saris; Lu Min Wong; Matthew H Plant; Lisa Sherman; Matthew R Lee; Faye Hsieh; Andrew S Tasker
Discovery of pyridazinopyridinones as potent and selective p38 mitogen-activated protein kinase inhibitors.
Journal of medicinal chemistry 2010;53(17):6398-411.
2010: Vijay K Gore; Vu V Ma; Ruoyuan Yin; Joe Ligutti; David Immke; Elizabeth M Doherty; Mark H Norman
Structure-activity relationship (SAR) investigations of tetrahydroquinolines as BKCa agonists.
Bioorganic & medicinal chemistry letters 2010;20(12):3573-8.
2009: Adrian L Smith; Frenel F DeMorin; Nick A Paras; Qi Huang; Jeffrey K Petkus; Elizabeth M Doherty; Thomas Nixey; Joseph L Kim; Douglas A Whittington; Linda F Epstein; Matthew R Lee; Mark J Rose; Carol Babij; Manory Fernando; Kristen Hess; Quynh Le; Pedro Beltran; Josette Carnahan
Selective inhibitors of the mutant B-Raf pathway: discovery of a potent and orally bioavailable aminoisoquinoline.
Journal of medicinal chemistry 2009;52(20):6189-92.
2008: Elizabeth M Doherty; Daniel Retz; Narender R Gavva; Rami Tamir; James J S Treanor; Mark H Norman
4-Aminopyrimidine tetrahydronaphthols: a series of novel vanilloid receptor-1 antagonists with improved solubility properties.
Bioorganic & medicinal chemistry letters 2008;18(6):1830-4.
2007: Hui-Ling Wang; Jodie Katon; Chenera Balan; Anthony W Bannon; Charles Bernard; Elizabeth M Doherty; Celia Dominguez; Narender R Gavva; Vijay K Gore; Vu V Ma; Nobuko Nishimura; Sekhar Surapaneni; Phi Tang; Rami Tamir; Oliver Thiel; James J S Treanor; Mark H Norman
Novel vanilloid receptor-1 antagonists: 3. The identification of a second-generation clinical candidate with improved physicochemical and pharmacokinetic properties.
Journal of medicinal chemistry 2007;50(15):3528-39.
2007: Elizabeth M Doherty; Christopher Fotsch; Anthony W Bannon; Yunxin Bo; Ning Chen; Celia Dominguez; James Falsey; Narender R Gavva; Jodie Katon; Thomas Nixey; Vassil I Ognyanov; Liping Pettus; Robert M Rzasa; Markian Stec; Sekhar Surapaneni; Rami Tamir; Jiawang Zhu; James J S Treanor; Mark H Norman
Novel vanilloid receptor-1 antagonists: 2. Structure-activity relationships of 4-oxopyrimidines leading to the selection of a clinical candidate.
Journal of medicinal chemistry 2007;50(15):3515-27.
2007: Mark H Norman; Jiawang Zhu; Christopher Fotsch; Yunxin Bo; Ning Chen; Partha P Chakrabarti; Elizabeth M Doherty; Narender R Gavva; Nobuko Nishimura; Thomas Nixey; Vassil I Ognyanov; Robert M Rzasa; Markian Stec; Sekhar Surapaneni; Rami Tamir; Vellarkad Viswanadhan; James J S Treanor
Novel vanilloid receptor-1 antagonists: 1. Conformationally restricted analogues of trans-cinnamides.
Journal of medicinal chemistry 2007;50(15):3497-514.
2005: Ning Xi; Yunxin Bo; Elizabeth M Doherty; Christopher Fotsch; Narender R Gavva; Nianhe Han; Randall W Hungate; Lana Klionsky; Qingyian Liu; Rami Tamir; Shimin Xu; James J S Treanor; Mark H Norman
Synthesis and evaluation of thiazole carboxamides as vanilloid receptor 1 (TRPV1) antagonists.
Bioorganic & medicinal chemistry letters 2005;15(23):5211-7.
2005: Narender R Gavva; Rami Tamir; Yusheng Qu; Lana Klionsky; Tie J Zhang; David C Immke; Judy Wang; Dawn Zhu; Todd W Vanderah; Frank Porreca; Elizabeth M Doherty; Mark H Norman; Kenneth D Wild; Anthony W Bannon; Jean-Claude Louis; James J S Treanor
AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties.
The Journal of pharmacology and experimental therapeutics 2005;313(1):474-84.
2005: Elizabeth M Doherty; Christopher Fotsch; Yunxin Bo; Partha P Chakrabarti; Ning Chen; Narender R Gavva; Nianhe Han; Michael G Kelly; John Kincaid; Lana Klionsky; Qingyian Liu; Vassil I Ognyanov; Rami Tamir; Xianghong Wang; Jiawang Zhu; Mark H Norman; James J S Treanor
Discovery of potent, orally available vanilloid receptor-1 antagonists. Structure-activity relationship of N-aryl cinnamides.
Journal of medicinal chemistry 2005;48(1):71-90.
2003: Christopher Fotsch; Duncan M Smith; Jeffrey A Adams; Janet Cheetham; Michael Croghan; Elizabeth M Doherty; Clarence Hale; Mark Jarosinski; Michael G Kelly; Mark H Norman; Nuria A Tamayo; Ning Xi; James W Baumgartner
Design of a new peptidomimetic agonist for the melanocortin receptors based on the solution structure of the peptide ligand, Ac-Nle-cyclo[Asp-Pro-DPhe-Arg-Trp-Lys]-NH(2).
Bioorganic & medicinal chemistry letters 2003;13(14):2337-40.