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Henrik Dohlman

Research Profile

Living Beings

Saccharomyces cerevisiae

Chemicals & Drugs

Physiology

Genes & Molecular Sequences

Amino Acid Sequences

Concepts & Ideas

Phenomena

Phosphorylation

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Publications

TOP 3
Evan C Lien; Michal J Nagiec; Henrik G Dohlman
Proper protein glycosylation promotes mitogen-activated protein kinase signal fidelity.
Rachael Baker; Lewis C Cantley; Henrik G Dohlman; Brian Kuhlman; Steven M Lewis; Jason W Locasale; Atsuo T Sasaki; Emily M Wilkerson; Sharon L Campbell
Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function.
Nan Hao; Michal J Nagiec; Stephen C Parnell; Necmettin Yildirim; Henrik G Dohlman; Beverly Errede; Timothy C Elston
Combined computational and experimental analysis reveals mitogen-activated protein kinase-mediated feedback phosphorylation as a mechanism for signaling specificity.

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All Publications

2013: Evan C Lien; Michal J Nagiec; Henrik G Dohlman
Proper protein glycosylation promotes mitogen-activated protein kinase signal fidelity.
Biochemistry 2013;52(1):115-24.
2013: Rachael Baker; Lewis C Cantley; Henrik G Dohlman; Brian Kuhlman; Steven M Lewis; Jason W Locasale; Atsuo T Sasaki; Emily M Wilkerson; Sharon L Campbell
Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function.
Nature structural & molecular biology 2013;20(1):46-52.
2012: Nan Hao; Michal J Nagiec; Stephen C Parnell; Necmettin Yildirim; Henrik G Dohlman; Beverly Errede; Timothy C Elston
Combined computational and experimental analysis reveals mitogen-activated protein kinase-mediated feedback phosphorylation as a mechanism for signaling specificity.
Molecular biology of the cell 2012;23(19):3899-910.
2012: Henrik G Dohlman; Janice C Jones
Signal activation and inactivation by the Gα helical domain: a long-neglected partner in G protein signaling.
Science signaling 2012;5(226):re2.
2012: Janice C Jones; Brenda R S Temple; Alan M Jones; Henrik G Dohlman
Differences in intradomain and interdomain motion confer distinct activation properties to structurally similar Gα proteins.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(19):7275-9.
2011: Meng Jin; Will Mather; Sujata Nayak; Marcelo Behar; Henrik G Dohlman; Beverly Errede; Jeff Hasty; Timothy C Elston
Yeast dynamically modify their environment to achieve better mating efficiency.
Science signaling 2011;4(186):ra54.
2011: Matthew P Torres; Sarah T Clement; Steven D Cappell; Henrik G Dohlman
Cell cycle-dependent phosphorylation and ubiquitination of a G protein alpha subunit.
The Journal of biological chemistry 2011;286(23):20208-16.
2011: Janice C Jones; Jeffrey W Duffy; Mischa Machius; Brenda Temple; Henrik G Dohlman; Alan M Jones
The crystal structure of a self-activating G protein alpha subunit reveals its distinct mechanism of signal initiation.
Science signaling 2011;4(159):ra8.
2010: Steven D Cappell; Rachael Baker; Dorota Skowyra; Henrik G Dohlman
Systematic analysis of essential genes reveals important regulators of G protein signaling.
Molecular cell 2010;38(5):746-57.
2009: Erin J Heenan; Janeen L Vanhooke; Brenda Temple; Laurie Betts; John Sondek; Henrik G Dohlman
Structure and function of Vps15 in the endosomal G protein signaling pathway.
Biochemistry 2009;48(27):6390-401.
2009: Matthew P Torres; Michael J Lee; Feng Ding; Carrie Purbeck; Brian Kuhlman; Nikolay V Dokholyan; Henrik G Dohlman
G Protein Mono-ubiquitination by the Rsp5 Ubiquitin Ligase.
The Journal of biological chemistry 2009;284(13):8940-50.
2008: Nan Hao; Yaxue Zeng; Timothy C Elston; Henrik G Dohlman
Control of MAPK specificity by feedback phosphorylation of shared adaptor protein Ste50.
The Journal of biological chemistry 2008;283(49):33798-802.
2008: Marcelo Behar; Nan Hao; Henrik G Dohlman; Timothy C Elston
Dose-to-duration encoding and signaling beyond saturation in intracellular signaling networks.
PLoS computational biology 2008;4(10):e1000197.
2008: Charles R Esther; Juliana I Sesma; Henrik G Dohlman; Addison D Ault; Marién L Clas; Eduardo R Lazarowski; Richard C Boucher
Similarities between UDP-glucose and adenine nucleotide release in yeast: involvement of the secretory pathway.
Biochemistry 2008;47(35):9269-78.
2008: Nan Hao; Sujata Nayak; Marcelo Behar; Ryan H Shanks; Michal J Nagiec; Beverly Errede; Jeffrey Hasty; Timothy C Elston; Henrik G Dohlman
Regulation of cell signaling dynamics by the protein kinase-scaffold Ste5.
Molecular cell 2008;30(5):649-56.
2008: Michael J Lee; Henrik G Dohlman
Coactivation of G protein signaling by cell-surface receptors and an intracellular exchange factor.
Current biology : CB 2008;18(3):211-5.
2008: Henrik G Dohlman
A scaffold makes the switch.
Science signaling 2008;1(42):pe46.
2007: Marcelo Behar; Henrik G Dohlman; Timothy C Elston
Kinetic insulation as an effective mechanism for achieving pathway specificity in intracellular signaling networks.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(41):16146-51.
2007: Corinne E Zeller; Henrik G Dohlman
Illuminating Gbeta5 signaling.
Molecular pharmacology 2007;72(4):810-1.
2007: Corinne E Zeller; Stephen C Parnell; Henrik G Dohlman
The RACK1 ortholog Asc1 functions as a G-protein beta subunit coupled to glucose responsiveness in yeast.
The Journal of biological chemistry 2007;282(34):25168-76.
2007: Marcelo Behar; Nan Hao; Henrik G Dohlman; Timothy C Elston
Mathematical and computational analysis of adaptation via feedback inhibition in signal transduction pathways.
Biophysical journal 2007;93(3):806-21.
2007: Nan Hao; Marcelo Behar; Timothy C Elston; Henrik G Dohlman
Systems biology analysis of G protein and MAP kinase signaling in yeast.
Oncogene 2007;26(22):3254-66.
2007: Nan Hao; Marcelo Behar; Stephen C Parnell; Matthew P Torres; Christoph H Borchers; Timothy C Elston; Henrik G Dohlman
A systems-biology analysis of feedback inhibition in the Sho1 osmotic-stress-response pathway.
Current biology : CB 2007;17(8):659-67.
2006: Yuqi Wang; Henrik G Dohlman
Regulation of G protein and mitogen-activated protein kinase signaling by ubiquitination: insights from model organisms.
Circulation research 2006;99(12):1305-14.
2006: Henrik G Dohlman; Janna E Slessareva
Pheromone signaling pathways in yeast.
Science's STKE : signal transduction knowledge environment 2006;2006(364):cm6.
2006: Janna E Slessareva; Henrik G Dohlman
G protein signaling in yeast: new components, new connections, new compartments.
Science (New York, N.Y.) 2006;314(5804):1412-3.
2006: Daniel R Ballon; Paul Flanary; Douglas Paul Gladue; James B Konopka; Henrik G Dohlman; Jeremy Thorner
DEP-domain-mediated regulation of GPCR signaling responses.
Cell 2006;126(6):1079-93.
2006: Janna E Slessareva; Sheri M Routt; Brenda Temple; Vytas A Bankaitis; Henrik G Dohlman
Activation of the phosphatidylinositol 3-kinase Vps34 by a G protein alpha subunit at the endosome.
Cell 2006;126(1):191-203.
2006: xiao wang; Nan Hao; Henrik G Dohlman; Timothy C Elston
Bistability, stochasticity, and oscillations in the mitogen-activated protein kinase cascade.
Biophysical journal 2006;90(6):1961-78.
2006: Scott A Chasse; Paul Flanary; Stephen C Parnell; Nan Hao; Jiyoung Y Cha; David Siderovski; Henrik G Dohlman
Genome-scale analysis reveals Sst2 as the principal regulator of mating pheromone signaling in the yeast Saccharomyces cerevisiae.
Eukaryotic cell 2006;5(2):330-46.
2006: Yuqi Wang; Henrik G Dohlman
Pheromone-regulated sumoylation of transcription factors that mediate the invasive to mating developmental switch in yeast.
The Journal of biological chemistry 2006;281(4):1964-9.
2005: Stephen C Parnell; Louis A Marotti; Lee Kiang; Matthew P Torres; Christoph H Borchers; Henrik G Dohlman
Phosphorylation of the RGS protein Sst2 by the MAP kinase Fus3 and use of Sst2 as a model to analyze determinants of substrate sequence specificity.
Biochemistry 2005;44(22):8159-66.
2005: Gary L Johnson; Henrik G Dohlman; Lee M Graves
MAPK kinase kinases (MKKKs) as a target class for small-molecule inhibition to modulate signaling networks and gene expression.
Current opinion in chemical biology 2005;9(3):325-31.
2005: Yuqi Wang; Louis A Marotti; Michael J Lee; Henrik G Dohlman
Differential regulation of G protein alpha subunit trafficking by mono- and polyubiquitination.
The Journal of biological chemistry 2005;280(1):284-91.
2004: Yuqi Wang; Henrik G Dohlman
Pheromone signaling mechanisms in yeast: a prototypical sex machine.
Science (New York, N.Y.) 2004;306(5701):1508-9.
2004: Seth Maleri; Qingyuan Ge; Elizabeth A Hackett; Yuqi Wang; Henrik G Dohlman; Beverly Errede
Persistent activation by constitutive Ste7 promotes Kss1-mediated invasive growth but fails to support Fus3-dependent mating in yeast.
Molecular and cellular biology 2004;24(20):9221-38.
2004: Yuh-Lin Wu; Shelley Hooks Pence; T Kendall Harden; Henrik G Dohlman
Dominant-negative inhibition of pheromone receptor signaling by a single point mutation in the G protein alpha subunit.
The Journal of biological chemistry 2004;279(34):35287-97.
2004: Scott A Chasse; Henrik G Dohlman
Identification of yeast pheromone pathway modulators by high-throughput agonist response profiling of a yeast gene knockout strain collection.
Methods in enzymology 2004;389():399-409.
2004: Necmettin Yildirim; Nan Hao; Henrik G Dohlman; Timothy C Elston
Mathematical modeling of RGS and G-protein regulation in yeast.
Methods in enzymology 2004;389():383-98.
2003: Nan Hao; Necmettin Yildirim; Yuqi Wang; Timothy C Elston; Henrik G Dohlman
Regulators of G protein signaling and transient activation of signaling: experimental and computational analysis reveals negative and positive feedback controls on G protein activity.
The Journal of biological chemistry 2003;278(47):46506-15.
2003: Ming Guo; Christopher Aston; Scott A Burchett; Christine Dyke; Stanley Fields; S Johannes R Rajarao; Peter Uetz; Yuqi Wang; Kathleen Young; Henrik G Dohlman
The yeast G protein alpha subunit Gpa1 transmits a signal through an RNA binding effector protein Scp160.
Molecular cell 2003;12(2):517-24.
2003: Yuqi Wang; Qing Ge; Dayle Houston; Jeremy Thorner; Beverly Errede; Henrik G Dohlman
Regulation of Ste7 ubiquitination by Ste11 phosphorylation and the Skp1-Cullin-F-box complex.
The Journal of biological chemistry 2003;278(25):22284-9.
2003: Scott A Chasse; Henrik G Dohlman
RGS proteins: G protein-coupled receptors meet their match.
Assay and drug development technologies 2003;1(2):357-64.
2003: Aristidis Sachpatzidis; Benjamin K Benton; John P Manfredi; Hua Wang; Andrew Hamilton; Henrik G Dohlman; Elias Lolis
Identification of allosteric peptide agonists of CXCR4.
The Journal of biological chemistry 2003;278(2):896-907.
2002: Henrik G Dohlman
Diminishing returns.
Nature 2002;418(6898):591.
2002: Scott A Burchett; Paul Flanary; Christopher Aston; Lixin Jiang; Kathleen H Young; Peter Uetz; Stanley Fields; Henrik G Dohlman
Regulation of stress response signaling by the N-terminal dishevelled/EGL-10/pleckstrin domain of Sst2, a regulator of G protein signaling in Saccharomyces cerevisiae.
The Journal of biological chemistry 2002;277(25):22156-67.
2002: Yuqi Wang; Henrik G Dohlman
Pheromone-dependent ubiquitination of the mitogen-activated protein kinase kinase Ste7.
The Journal of biological chemistry 2002;277(18):15766-72.
2002: Louis A Marotti; Rick Newitt; Yuqi Wang; Ruedi Aebersold; Henrik G Dohlman
Direct identification of a G protein ubiquitination site by mass spectrometry.
Biochemistry 2002;41(16):5067-74.
2002: Henrik G Dohlman
G proteins and pheromone signaling.
Annual review of physiology 2002;64():129-52.
2002: Tiffany garrison; Donald M Apanovitch; Henrik G Dohlman
Purification of RGS protein, Sst2, from Saccharomyces cerevisiae and Escherichia coli.
Methods in enzymology 2002;344():632-47.
2002: Ginger A Hoffman; Tiffany garrison; Henrik G Dohlman
Analysis of RGS proteins in Saccharomyces cerevisiae.
Methods in enzymology 2002;344():617-31.
2001: Scott A Burchett; A Scott; Beverly Errede; Henrik G Dohlman
Identification of novel pheromone-response regulators through systematic overexpression of 120 protein kinases in yeast.
The Journal of biological chemistry 2001;276(28):26472-8.
2001: Henrik G Dohlman; Jeremy Thorner
Regulation of G protein-initiated signal transduction in yeast: paradigms and principles.
Annual review of biochemistry 2001;70():703-54.
2000: G A Hoffman; Tiffany garrison; Henrik G Dohlman
Endoproteolytic processing of Sst2, a multidomain regulator of G protein signaling in yeast.
The Journal of biological chemistry 2000;275(48):37533-41.
2000: K N Ehrhard; Jörg J Jacoby; Xin-Yuan Fu; Reinhard Jahn; Henrik G Dohlman
Use of G-protein fusions to monitor integral membrane protein-protein interactions in yeast.
Nature biotechnology 2000;18(10):1075-9.
2000: Paul Flanary; PR DiBello; P Estrada; Henrik G Dohlman
Functional analysis of Plp1 and Plp2, two homologues of phosducin in yeast.
The Journal of biological chemistry 2000;275(24):18462-9.
2000: F Li; Paul Flanary; Dario C Altieri; Henrik G Dohlman
Cell division regulation by BIR1, a member of the inhibitor of apoptosis family in yeast.
The Journal of biological chemistry 2000;275(10):6707-11.
1999: Tiffany garrison; Yalan Zhang; MH Pausch; Donald M Apanovitch; Ruedi Aebersold; Henrik G Dohlman
Feedback phosphorylation of an RGS protein by MAP kinase in yeast.
The Journal of biological chemistry 1999;274(51):36387-91.
1998: K M Gillen; MH Pausch; Henrik G Dohlman
N-terminal domain of Gpa1 (G protein alpha) subunit) is sufficient for plasma membrane targeting in yeast Saccharomyces cerevisiae.
Journal of cell science 1998;111 ( Pt 21)():3235-44.
1998: Donald M Apanovitch; Taroh Iiri; T Karasawa; Henry R Bourne; Henrik G Dohlman
Second site suppressor mutations of a GTPase-deficient G-protein alpha-subunit. Selective inhibition of Gbeta gamma-mediated signaling.
The Journal of biological chemistry 1998;273(44):28597-602.
1998: KL Lan; Noune A Sarvazyan; Ronald Taussig; Robert George MacKenzie; PR DiBello; Henrik G Dohlman; Richard Neubig
A point mutation in Galphao and Galphai1 blocks interaction with regulator of G protein signaling proteins.
The Journal of biological chemistry 1998;273(21):12794-7.
1998: Donald M Apanovitch; KC Slep; Paul B Sigler; Henrik G Dohlman
Sst2 is a GTPase-activating protein for Gpa1: purification and characterization of a cognate RGS-Galpha protein pair in yeast.
Biochemistry 1998;37(14):4815-22.
1998: Henrik G Dohlman; J Song; Donald M Apanovitch; PR DiBello; K M Gillen
Regulation of G protein signalling in yeast.
Seminars in cell & developmental biology 1998;9(2):135-41.
1998: PR DiBello; Tiffany garrison; Donald M Apanovitch; G Hoffman; D J Shuey; K Mason; Mark Cockett; Henrik G Dohlman
Selective uncoupling of RGS action by a single point mutation in the G protein alpha-subunit.
The Journal of biological chemistry 1998;273(10):5780-4.
1997: Stephen J Gold; Yan G Ni; Henrik G Dohlman; Eric J Nestler
Regulators of G-protein signaling (RGS) proteins: region-specific expression of nine subtypes in rat brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(20):8024-37.
1997: Henrik G Dohlman; Jeremy Thorner
RGS proteins and signaling by heterotrimeric G proteins.
The Journal of biological chemistry 1997;272(7):3871-4.
1996: E Kübler; Henrik G Dohlman; Michael P Lisanti
Identification of Triton X-100 insoluble membrane domains in the yeast Saccharomyces cerevisiae. Lipid requirements for targeting of heterotrimeric G-protein subunits.
The Journal of biological chemistry 1996;271(51):32975-80.
1996: J Song; Henrik G Dohlman
Partial constitutive activation of pheromone responses by a palmitoylation-site mutant of a G protein alpha subunit in yeast.
Biochemistry 1996;35(47):14806-17.
1996: Henrik G Dohlman; J Song; D Ma; W E Courchesne; Jeremy Thorner
Sst2, a negative regulator of pheromone signaling in the yeast Saccharomyces cerevisiae: expression, localization, and genetic interaction and physical association with Gpa1 (the G-protein alpha subunit).
Molecular and cellular biology 1996;16(9):5194-209.
1996: J Song; J Hirschman; K Gunn; Henrik G Dohlman
Regulation of membrane and subunit interactions by N-myristoylation of a G protein alpha subunit in yeast.
The Journal of biological chemistry 1996;271(34):20273-83.
1995: Henrik G Dohlman; D Apaniesk; Y Chen; J Song; D Nusskern
Inhibition of G-protein signaling by dominant gain-of-function mutations in Sst2p, a pheromone desensitization factor in Saccharomyces cerevisiae.
Molecular and cellular biology 1995;15(7):3635-43.
1993: Henrik G Dohlman
Hormone signal response system.
Nature 1993;366(6453):307-8.
1993: Henrik G Dohlman; P Goldsmith; Allen Spiegel; Jeremy Thorner
Pheromone action regulates G-protein alpha-subunit myristoylation in the yeast Saccharomyces cerevisiae.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(20):9688-92.
1993: K Kuchler; Henrik G Dohlman; Jeremy Thorner
The a-factor transporter (STE6 gene product) and cell polarity in the yeast Saccharomyces cerevisiae.
The Journal of cell biology 1993;120(5):1203-15.
1991: Henrik G Dohlman; Jeremy Thorner; Marc G Caron; R J Lefkowitz
Model systems for the study of seven-transmembrane-segment receptors.
Annual review of biochemistry 1991;60():653-88.
1990: K King; Henrik G Dohlman; Jeremy Thorner; Marc G Caron; R J Lefkowitz
Control of yeast mating signal transduction by a mammalian beta 2-adrenergic receptor and Gs alpha subunit.
Science (New York, N.Y.) 1990;250(4977):121-3.
1990: Henrik G Dohlman; Marc G Caron; A DeBlasi; T Frielle; R J Lefkowitz
Role of extracellular disulfide-bonded cysteines in the ligand binding function of the beta 2-adrenergic receptor.
Biochemistry 1990;29(9):2335-42.
1990: J L Benovic; J Onorato; M J Lohse; Henrik G Dohlman; C Staniszewski; Marc G Caron; R J Lefkowitz
Synthetic peptides of the hamster beta 2-adrenoceptor as substrates and inhibitors of the beta-adrenoceptor kinase.
British journal of clinical pharmacology 1990;30 Suppl 1():3S-12S.
1988: Henrik G Dohlman; Marc G Caron; C D Strader; N Amlaiky; R J Lefkowitz
Identification and sequence of a binding site peptide of the beta 2-adrenergic receptor.
Biochemistry 1988;27(6):1813-7.
1988: R J Lefkowitz; B K Kobilka; J L Benovic; Michel Bouvier; S Cotecchia; W P Hausdorff; Henrik G Dohlman; John W Regan; Marc G Caron
Molecular biology of adrenergic receptors.
Cold Spring Harbor symposia on quantitative biology 1988;53 Pt 1():507-14.
1987: Henrik G Dohlman; Marc G Caron; R J Lefkowitz
Structure and function of the beta 2-adrenergic receptor--homology with rhodopsin.
Kidney international. Supplement 1987;23():S2-13.
1987: Henrik G Dohlman; Michel Bouvier; J L Benovic; Marc G Caron; R J Lefkowitz
The multiple membrane spanning topography of the beta 2-adrenergic receptor. Localization of the sites of binding, glycosylation, and regulatory phosphorylation by limited proteolysis.
The Journal of biological chemistry 1987;262(29):14282-8.
1987: B K Kobilka; T Frielle; Henrik G Dohlman; M A Bolanowski; R A Dixon; P Keller; Marc G Caron; R J Lefkowitz
Delineation of the intronless nature of the genes for the human and hamster beta 2-adrenergic receptor and their putative promoter regions.
The Journal of biological chemistry 1987;262(15):7321-7.
1987: Henrik G Dohlman; Marc G Caron; R J Lefkowitz
A family of receptors coupled to guanine nucleotide regulatory proteins.
Biochemistry 1987;26(10):2657-64.
1987: B K Kobilka; R A Dixon; T Frielle; Henrik G Dohlman; M A Bolanowski; I S Sigal; T L Yang-Feng; U Francke; Marc G Caron; R J Lefkowitz
cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(1):46-50.
1986: R A Dixon; B K Kobilka; D J Strader; J L Benovic; Henrik G Dohlman; T Frielle; M A Bolanowski; C D Bennett; Elaine Rands; R E Diehl; R A Mumford; E E Slater; I S Sigal; Marc G Caron; R J Lefkowitz; C D Strader
Cloning of the gene and cDNA for mammalian beta-adrenergic receptor and homology with rhodopsin.
Nature 1986;321(6065):75-9.
1982: D M Albert; J R Gonder; J Papale; J L Craft; Henrik G Dohlman; M C Reid; F W Sunderman
Induction of ocular neoplasms in Fischer rats by intraocular injection of nickel subsulfide.
Investigative ophthalmology & visual science 1982;22(6):768-82.
1982: L H Liu; D M Albert; Henrik G Dohlman; N Chuo
Metastasis in a rabbit choroidal melanoma model.
Investigative ophthalmology & visual science 1982;22(1):115-8.
1980: D M Albert; J A Shadduck; H S Liu; F W Sunderman; M D Wagoner; Henrik G Dohlman; J J Papale
Animal models for the study of uveal melanoma.
International ophthalmology clinics 1980;20(2):143-60.