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Esteban Domingo

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TOP 3
Armando Arias; Cristina Escarmís; Ana Isabel de Ávila; Marta Sanz-Ramos; Rubén Agudo; Esteban Domingo
Molecular dissection of a viral quasispecies under mutagenic treatment: positive correlation between fitness loss and mutational load.
Celia Perales; Jaime Iranzo; Susanna C Manrubia; Esteban Domingo
The impact of quasispecies dynamics on the use of therapeutics.
Héctor Moreno; Esteban Domingo; Ana Grande-Pérez; Verónica Martín
Arenaviruses and lethal mutagenesis. Prospects for new ribavirin-based interventions.

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All Publications

2013: Armando Arias; Cristina Escarmís; Ana Isabel de Ávila; Marta Sanz-Ramos; Rubén Agudo; Esteban Domingo
Molecular dissection of a viral quasispecies under mutagenic treatment: positive correlation between fitness loss and mutational load.
The Journal of general virology 2013;94(Pt 4):817-30.
2012: Celia Perales; Jaime Iranzo; Susanna C Manrubia; Esteban Domingo
The impact of quasispecies dynamics on the use of therapeutics.
Trends in microbiology 2012;20(12):595-603.
2012: Héctor Moreno; Esteban Domingo; Ana Grande-Pérez; Verónica Martín
Arenaviruses and lethal mutagenesis. Prospects for new ribavirin-based interventions.
Viruses 2012;4(11):2786-805.
2012: Carmen Sánchez-Jiménez; Víctor Toledano; Ramón Lorenzo-Redondo; Isabel Olivares; Ana Isabel de Ávila Lucas; Esteban Domingo; Ana Grande-Pérez; Mónica Gutiérrez-Rivas; Cecilio López-Galíndez
Mutagen-mediated enhancement of HIV-1 replication in persistently infected cells.
Virology 2012;424(2):147-53.
2012: Héctor Moreno; Héctor Tejero; Juan Carlos de la Torre; Esteban Domingo; Verónica Martín
Mutagenesis-mediated virus extinction: virus-dependent effect of viral load on sensitivity to lethal defection.
PloS one 2012;7(3):e32550.
2011: Samuel Ojosnegros; Celia Perales; Antonio Mas; Esteban Domingo
Quasispecies as a matter of fact: viruses and beyond.
Virus research 2011;162(1-2):203-15.
2011: Celia Perales; Verónica Martín; Esteban Domingo
Lethal mutagenesis of viruses.
Current opinion in virology 2011;1(5):419-22.
2011: Jaime Iranzo; Esteban Domingo; Celia Perales; Susanna C Manrubia
Tempo and mode of inhibitor-mutagen antiviral therapies: a multidisciplinary approach.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(38):16008-13.
2011: Héctor Moreno; Noemí Sevilla; Juan Carlos de la Torre; Esteban Domingo; Isabel Gallego; Verónica Martín
Ribavirin can be mutagenic for arenaviruses.
Journal of virology 2011;85(14):7246-55.
2011: Celia Perales; Rubén Agudo; Susanna C Manrubia; Esteban Domingo
Influence of mutagenesis and viral load on the sustained low-level replication of an RNA virus.
Journal of molecular biology 2011;407(1):60-78.
2011: Esteban Domingo
Paradoxical interplay of viral and cellular functions.
Viruses 2011;3(3):272-7.
2011: Samuel Ojosnegros; Juan García-Arriaza; Cristina Escarmís; Susanna C Manrubia; Celia Perales; Armando Arias; Mauricio G Mateu; Esteban Domingo
Viral genome segmentation can result from a trade-off between genetic content and particle stability.
PLoS genetics 2011;7(3):e1001344.
2010: Miguel A Martín-Acebes; Mónica Herrera; Rosario Armas-Portela; Esteban Domingo; Francisco Sobrino
Cell density-dependent expression of viral antigens during persistence of foot-and-mouth disease virus in cell culture.
Virology 2010;403(1):47-55.
2010: Cristina Ferrer-Orta; Macarena Sierra; Rubén Agudo; Ignacio de la Higuera; Armando Arias; Rosa Pérez-Luque; Cristina Escarmís; Esteban Domingo; Nuria Verdaguer
Structure of foot-and-mouth disease virus mutant polymerases with reduced sensitivity to ribavirin.
Journal of virology 2010;84(12):6188-99.
2010: Verónica Martín; David Abia; Esteban Domingo; Ana Grande-Pérez
An interfering activity against lymphocytic choriomeningitis virus replication associated with enhanced mutagenesis.
The Journal of general virology 2010;91(Pt 4):990-1003.
2010: Samuel Ojosnegros; Niko Beerenwinkel; Tibor Antal; Martin A Nowak; Cristina Escarmís; Esteban Domingo
Competition-colonization dynamics in an RNA virus.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(5):2108-12.
2010: Rubén Agudo; Cristina Ferrer-Orta; Armando Arias; Ignacio de la Higuera; Celia Perales; Rosa Pérez-Luque; Nuria Verdaguer; Esteban Domingo
A multi-step process of viral adaptation to a mutagenic nucleoside analogue by modulation of transition types leads to extinction-escape.
PLoS pathogens 2010;6(8):e1001072.
2010: Teresa Rodríguez-Calvo; Samuel Ojosnegros; Marta Sanz-Ramos; Juan García-Arriaza; Cristina Escarmís; Esteban Domingo; Noemí Sevilla
New vaccine design based on defective genomes that combines features of attenuated and inactivated vaccines.
PloS one 2010;5(4):e10414.
2010: Antonio V Bordería; Ramon Lorenzo-Redondo; Maria Pernas; Concepcion Casado; Tamara Alvaro; Esteban Domingo; Cecilio Lopez-Galindez
Initial fitness recovery of HIV-1 is associated with quasispecies heterogeneity and can occur without modifications in the consensus sequence.
PloS one 2010;5(4):e10319.
2009: Cristina Ferrer-Orta; Rubén Agudo; Esteban Domingo; Nuria Verdaguer
Structural insights into replication initiation and elongation processes by the FMDV RNA-dependent RNA polymerase.
Current opinion in structural biology 2009;19(6):752-8.
2009: Sebastien F Emonet; Juan C de la Torre; Esteban Domingo; Noemí Sevilla
Arenavirus genetic diversity and its biological implications.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2009;9(4):417-29.
2009: Cristina Escarmís; Celia Perales; Esteban Domingo
Biological effect of Muller's Ratchet: distant capsid site can affect picornavirus protein processing.
Journal of virology 2009;83(13):6748-56.
2009: Rubén Agudo; Armando Arias; Esteban Domingo
5-fluorouracil in lethal mutagenesis of foot-and-mouth disease virus.
Future medicinal chemistry 2009;1(3):529-39.
2009: Esteban Domingo; Simon Wain-Hobson
The 30th anniversary of quasispecies. Meeting on 'Quasispecies: past, present and future'.
EMBO reports 2009;10(5):444-8.
2009: Celia Perales; Rubén Agudo; Esteban Domingo
Counteracting quasispecies adaptability: extinction of a ribavirin-resistant virus mutant by an alternative mutagenic treatment.
PloS one 2009;4(5):e5554.
2008: Rubén Agudo; Armando Arias; Nonia Pariente; Celia Perales; Cristina Escarmís; Alberto Jorge; Anabel Marina; Esteban Domingo
Molecular characterization of a dual inhibitory and mutagenic activity of 5-fluorouridine triphosphate on viral RNA synthesis. Implications for lethal mutagenesis.
Journal of molecular biology 2008;382(3):652-66.
2008: Esteban Domingo; Ana Grande-Pérez; Verónica Martín
Future prospects for the treatment of rapidly evolving viral pathogens: insights from evolutionary biology.
Expert opinion on biological therapy 2008;8(10):1455-60.
2008: Verónica Martín; Ana Grande-Pérez; Esteban Domingo
No evidence of selection for mutational robustness during lethal mutagenesis of lymphocytic choriomeningitis virus.
Virology 2008;378(1):185-92.
2008: Verónica Martín; Esteban Domingo
Influence of the mutant spectrum in viral evolution: focused selection of antigenic variants in a reconstructed viral quasispecies.
Molecular biology and evolution 2008;25(8):1544-54.
2008: Cristina Escarmís; Ester Lázaro; Armando Arias; Esteban Domingo
Repeated bottleneck transfers can lead to non-cytocidal forms of a cytopathic virus: implications for viral extinction.
Journal of molecular biology 2008;376(2):367-79.
2008: Esteban Domingo; V Martin; Celia Perales; C Escarmis
Coxsackieviruses and quasispecies theory: evolution of enteroviruses.
Current topics in microbiology and immunology 2008;323():3-32.
2008: Mónica Herrera; Ana Grande-Pérez; Celia Perales; Esteban Domingo
Persistence of foot-and-mouth disease virus in cell culture revisited: implications for contingency in evolution.
The Journal of general virology 2008;89(Pt 1):232-44.
2007: Juan García-Arriaza; Esteban Domingo; Carlos Briones
Characterization of minority subpopulations in the mutant spectrum of HIV-1 quasispecies by successive specific amplifications.
Virus research 2007;129(2):123-34.
2007: José Ignacio Núñez; Nicolás Molina; Eric Baranowski; Esteban Domingo; Stuart Clark; Alison Burman; Stephen Berryman; Terry Jackson; Francisco Sobrino
Guinea pig-adapted foot-and-mouth disease virus with altered receptor recognition can productively infect a natural host.
Journal of virology 2007;81(16):8497-506.
2007: Esteban Domingo; Jordi Gomez
Quasispecies and its impact on viral hepatitis.
Virus research 2007;127(2):131-50.
2007: Celia Perales; Roberto Mateo; Mauricio G Mateu; Esteban Domingo
Insights into RNA virus mutant spectrum and lethal mutagenesis events: replicative interference and complementation by multiple point mutants.
Journal of molecular biology 2007;369(4):985-1000.
2007: Cristina Ferrer-Orta; Armando Arias; Rosa Pérez-Luque; Cristina Escarmís; Esteban Domingo; Nuria Verdaguer
Sequential structures provide insights into the fidelity of RNA replication.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(22):9463-8.
2007: Mónica Herrera; Juan García-Arriaza; Nonia Pariente; Cristina Escarmís; Esteban Domingo
Molecular basis for a lack of correlation between viral fitness and cell killing capacity.
PLoS pathogens 2007;3(4):e53.
2007: Macarena Sierra; Antero Airaksinen; Claudia González-López; Rubén Agudo; Armando Arias; Esteban Domingo
Foot-and-mouth disease virus mutant with decreased sensitivity to ribavirin: implications for error catastrophe.
Journal of virology 2007;81(4):2012-24.
2006: Carlos Briones; Aránzazu de Vicente; Carmen Molina-París; Esteban Domingo
Minority memory genomes can influence the evolution of HIV-1 quasispecies in vivo.
Gene 2006;384():129-38.
2006: Verónica Martín; Celia Perales; Mercedes Dávila; Esteban Domingo
Viral fitness can influence the repertoire of virus variants selected by antibodies.
Journal of molecular biology 2006;362(1):44-54.
2006: Juan García-Arriaza; Samuel Ojosnegros; Mercedes Dávila; Esteban Domingo; Cristina Escarmís
Dynamics of mutation and recombination in a replicating population of complementing, defective viral genomes.
Journal of molecular biology 2006;360(3):558-72.
2006: Cristina Ferrer-Orta; Armando Arias; Rubén Agudo; Rosa Pérez-Luque; Cristina Escarmís; Esteban Domingo; Nuria Verdaguer
The structure of a protein primer-polymerase complex in the initiation of genome replication.
The EMBO journal 2006;25(4):880-8.
2006: Verónica Martín; Celia Perales; David Abia; Angel R Ortíz; Esteban Domingo; Carlos Briones
Microarray-based identification of antigenic variants of foot-and-mouth disease virus: a bioinformatics quality assessment.
BMC genomics 2006;7():117.
2006: Esteban Domingo; V Martin; Celia Perales; Ana Grande-Pérez; Juan García-Arriaza; Armando Arias
Viruses as quasispecies: biological implications.
Current topics in microbiology and immunology 2006;299():51-82.
2005: Armando Arias; Rubén Agudo; Cristina Ferrer-Orta; Rosa Pérez-Luque; Antero Airaksinen; Emiliana Brocchi; Esteban Domingo; Nuria Verdaguer; Cristina Escarmís
Mutant viral polymerase in the transition of virus to error catastrophe identifies a critical site for RNA binding.
Journal of molecular biology 2005;353(5):1021-32.
2005: Claudia González-López; Gema Gómez-Mariano; Cristina Escarmís; Esteban Domingo
Invariant aphthovirus consensus nucleotide sequence in the transition to error catastrophe.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2005;5(4):366-74.
2005: Ana Grande-Pérez; Gema Gómez-Mariano; Pedro R Lowenstein; Esteban Domingo
Mutagenesis-induced, large fitness variations with an invariant arenavirus consensus genomic nucleotide sequence.
Journal of virology 2005;79(16):10451-9.
2005: Juan García-Arriaza; Esteban Domingo; Cristina Escarmís
A segmented form of foot-and-mouth disease virus interferes with standard virus: a link between interference and competitive fitness.
Virology 2005;335(2):155-64.
2005: Eloísa Yuste; Antonio V Bordería; Esteban Domingo; Cecilio López-Galíndez
Few mutations in the 5' leader region mediate fitness recovery of debilitated human immunodeficiency type 1 viruses.
Journal of virology 2005;79(9):5421-7.
2005: Ana Grande-Pérez; Ester Lázaro; Pedro R Lowenstein; Esteban Domingo; Susanna C Manrubia
Suppression of viral infectivity through lethal defection.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(12):4448-52.
2005: Susanna C Manrubia; Cristina Escarmís; Esteban Domingo; Ester Lázaro
High mutation rates, bottlenecks, and robustness of RNA viral quasispecies.
Gene 2005;347(2):273-82.
2005: Esteban Domingo; Cristina Escarmís; Ester Lázaro; Susanna C Manrubia
Quasispecies dynamics and RNA virus extinction.
Virus research 2005;107(2):129-39.
2005: Celia Perales; Verónica Martín; Carmen M Ruiz-Jarabo; Esteban Domingo
Monitoring sequence space as a test for the target of selection in viruses.
Journal of molecular biology 2005;345(3):451-9.
2005: Esteban Domingo; C Gonzalez-Lopez; Nonia Pariente; Antero Airaksinen; Cristina Escarmís
Population dynamics of RNA viruses: the essential contribution of mutant spectra.
Archives of virology. Supplementum 2005;(19):59-71.
2005: Esteban Domingo; Nonia Pariente; Antero Airaksinen; C Gonzaĺez-Lopez; Saleta Sierra; M Herrera; Ana Grande-Pérez; Pedro R Lowenstein; Susanna C Manrubia; Ester Lázaro; Cristina Escarmís
Foot-and-mouth disease virus evolution: exploring pathways towards virus extinction.
Current topics in microbiology and immunology 2005;288():149-73.
2005: Isabel S Novella; Dorothy L Gilbertson; Belen Borrego; Esteban Domingo; John J Holland
Adaptability costs in immune escape variants of vesicular stomatitis virus.
Virus research 2005;107(1):27-34.
2004: Cristina Ferrer-Orta; Armando Arias; Rosa Perez-Luque; Cristina Escarmís; Esteban Domingo; Nuria Verdaguer
Structure of foot-and-mouth disease virus RNA-dependent RNA polymerase and its complex with a template-primer RNA.
The Journal of biological chemistry 2004;279(45):47212-21.
2004: Juan García-Arriaza; Susanna C Manrubia; Miguel Toja; Esteban Domingo; Cristina Escarmís
Evolutionary transition toward defective RNAs that are infectious by complementation.
Journal of virology 2004;78(21):11678-85.
2004: Carmen M Ruiz-Jarabo; Nonia Pariente; Eric Baranowski; Mercedes Dávila; Gema Gómez-Mariano; Esteban Domingo
Expansion of host-cell tropism of foot-and-mouth disease virus despite replication in a constant environment.
The Journal of general virology 2004;85(Pt 8):2289-97.
2004: Nonia Pariente; Maria Pernas; Rafael de la Rosa; Gema Gómez-Mariano; Guerau Fernández; Amalia Rubio; Mariola López; José Miguel Benito; Cecilio López-Galíndez; Manuel Leal; Esteban Domingo; Miguel Angel Martinez; Antonio Mas
Long-term suppression of plasma viremia with highly active antiretroviral therapy despite virus evolution and very limited selection of drug-resistant genotypes.
Journal of medical virology 2004;73(3):350-61.
2004: Armando Arias; Carmen M Ruiz-Jarabo; Cristina Escarmís; Esteban Domingo
Fitness increase of memory genomes in a viral quasispecies.
Journal of molecular biology 2004;339(2):405-12.
2004: Claudia González-López; Armando Arias; Nonia Pariente; Gema Gómez-Mariano; Esteban Domingo
Preextinction viral RNA can interfere with infectivity.
Journal of virology 2004;78(7):3319-24.
2003: Carmen M Ruiz-Jarabo; Eric Miller; Gema Gómez-Mariano; Esteban Domingo
Synchronous loss of quasispecies memory in parallel viral lineages: a deterministic feature of viral quasispecies.
Journal of molecular biology 2003;333(3):553-63.
2003: Glòria Sánchez; Albert Bosch; Gema Gómez-Mariano; Esteban Domingo; Rosa M Pintó
Evidence for quasispecies distributions in the human hepatitis A virus genome.
Virology 2003;315(1):34-42.
2003: Ester Lázaro; Cristina Escarmís; Juan Pérez-Mercader; Susanna C Manrubia; Esteban Domingo
Resistance of virus to extinction on bottleneck passages: study of a decaying and fluctuating pattern of fitness loss.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):10830-5.
2003: Carlos Briones; Esteban Domingo; Carmen Molina-París
Memory in retroviral quasispecies: experimental evidence and theoretical model for human immunodeficiency virus.
Journal of molecular biology 2003;331(1):213-29.
2003: Antero Airaksinen; Nonia Pariente; Luis Menéndez-Arias; Esteban Domingo
Curing of foot-and-mouth disease virus from persistently infected cells by ribavirin involves enhanced mutagenesis.
Virology 2003;311(2):339-49.
2003: Nonia Pariente; Antero Airaksinen; Esteban Domingo
Mutagenesis versus inhibition in the efficiency of extinction of foot-and-mouth disease virus.
Journal of virology 2003;77(12):7131-8.
2003: Susanna C Manrubia; Ester Lázaro; Juan Pérez-Mercader; Cristina Escarmís; Esteban Domingo
Fitness distributions in exponentially growing asexual populations.
Physical review letters 2003;90(18):188102.
2003: Carmen M Ruiz-Jarabo; Calvin Ly; Esteban Domingo; Juan Carlos de la Torre
Lethal mutagenesis of the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV).
Virology 2003;308(1):37-47.
2003: Eric Baranowski; Carmen M Ruiz-Jarabo; Nonia Pariente; Nuria Verdaguer; Esteban Domingo
Evolution of cell recognition by viruses: a source of biological novelty with medical implications.
Advances in virus research 2003;62():19-111.
2003: Esteban Domingo
Quasispecies and the development of new antiviral strategies.
Progress in drug research. Fortschritte der Arzneimittelforschung. Progrès des recherches pharmaceutiques 2003;60():133-58.
2003: Esteban Domingo; Cristina Escarmís; Eric Baranowski; Carmen M Ruiz-Jarabo; Elisa Carrillo; José Ignacio Núñez; Francisco Sobrino
Evolution of foot-and-mouth disease virus.
Virus research 2003;91(1):47-63.
2003: Cecilia Tami; Oscar Taboga; Analía Berinstein; José Ignacio Núñez; Eduardo L Palma; Esteban Domingo; Francisco Sobrino; Elisa Carrillo
Evidence of the coevolution of antigenicity and host cell tropism of foot-and-mouth disease virus in vivo.
Journal of virology 2003;77(2):1219-26.
2002: Antonio Mas; Blanca M Vázquez-Alvarez; Esteban Domingo; Luis Menéndez-Arias
Multidrug-resistant HIV-1 reverse transcriptase: involvement of ribonucleotide-dependent phosphorolysis in cross-resistance to nucleoside analogue inhibitors.
Journal of molecular biology 2002;323(2):181-97.
2002: Esteban Domingo; Eric Baranowski; Cristina Escarmís; Francisco Sobrino
Foot-and-mouth disease virus.
Comparative immunology, microbiology and infectious diseases 2002;25(5-6):297-308.
2002: Ana Grande-Pérez; Saleta Sierra; Maria G Castro; Esteban Domingo; Pedro R Lowenstein
Molecular indetermination in the transition to error catastrophe: systematic elimination of lymphocytic choriomeningitis virus through mutagenesis does not correlate linearly with large increases in mutant spectrum complexity.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(20):12938-43.
2002: Ester Lázaro; Cristina Escarmís; Esteban Domingo; Susanna C Manrubia
Modeling viral genome fitness evolution associated with serial bottleneck events: evidence of stationary states of fitness.
Journal of virology 2002;76(17):8675-81.
2002: Judit Villén; Eva Borràs; Wim M M Schaaper; Rob H Meloen; Mercedes Dávila; Esteban Domingo; Ernest Giralt; David Andreu
Functional mimicry of a discontinuous antigenic site by a designed synthetic peptide.
Chembiochem : a European journal of chemical biology 2002;3(2-3):175-82.
2002: Esteban Domingo; Carmen M Ruiz-Jarabo; Saleta Sierra; Armando Arias; Nonia Pariente; Eric Baranowski; Cristina Escarmis
Emergence and selection of RNA virus variants: memory and extinction.
Virus research 2002;82(1-2):39-44.
2002: Cristina Escarmís; Gema Gómez-Mariano; Mercedes Dávila; Ester Lázaro; Esteban Domingo
Resistance to extinction of low fitness virus subjected to plaque-to-plaque transfers: diversification by mutation clustering.
Journal of molecular biology 2002;315(4):647-61.
2002: Carmen M Ruíz-Jarabo; Armando Arias; Carmen Molina-París; Carlos Briones; Eric Baranowski; Cristina Escarmís; Esteban Domingo
Duration and fitness dependence of quasispecies memory.
Journal of molecular biology 2002;315(3):285-96.
2002: Noemí Sevilla; Esteban Domingo; Juan Carlos de la Torre
Contribution of LCMV towards deciphering biology of quasispecies in vivo.
Current topics in microbiology and immunology 2002;263():197-220.
2001: Nonia Pariente; Saleta Sierra; Pedro R Lowenstein; Esteban Domingo
Efficient virus extinction by combinations of a mutagen and antiviral inhibitors.
Journal of virology 2001;75(20):9723-30.
2001: Eric Baranowski; Carmen M Ruiz-Jarabo; F Lim; Esteban Domingo
Foot-and-mouth disease virus lacking the VP1 G-H loop: the mutant spectrum uncovers interactions among antigenic sites for fitness gain.
Virology 2001;288(2):192-202.
2001: Judit Villén; E Borràs; Wim M M Schaaper; Rob H Meloen; M Dávila; Esteban Domingo; Ernest Giralt; David Andreu
Synthetic peptides as functional mimics of a viral discontinuous antigenic site.
Biologicals : journal of the International Association of Biological Standardization 2001;29(3-4):265-9.
2001: J Quer; C L Hershey; Esteban Domingo; John J Holland; Isabel S Novella
Contingent neutrality in competing viral populations.
Journal of virology 2001;75(16):7315-20.
2001: Francisco Sobrino; Esteban Domingo
Foot-and-mouth disease in Europe. FMD is economically the most important disease of farm animals. Its re-emergence in Europe is likely to have consequences that go beyond severe alterations of livestock production and trade.
EMBO reports 2001;2(6):459-61.
2001: Eric Baranowski; Carmen M Ruiz-Jarabo; Esteban Domingo
Evolution of cell recognition by viruses.
Science (New York, N.Y.) 2001;292(5519):1102-5.
2001: Armando Arias; Ester Lázaro; Cristina Escarmís; Esteban Domingo
Molecular intermediates of fitness gain of an RNA virus: characterization of a mutant spectrum by biological and molecular cloning.
The Journal of general virology 2001;82(Pt 5):1049-60.
2001: José Ignacio Núñez; Eric Baranowski; Nicolás Molina; Carmen M Ruiz-Jarabo; C Sánchez; Esteban Domingo; Francisco Sobrino
A single amino acid substitution in nonstructural protein 3A can mediate adaptation of foot-and-mouth disease virus to the guinea pig.
Journal of virology 2001;75(8):3977-83.
2001: Carlos Briones; Antonio Mas; Mayte Pérez-Olmeda; C Altisent; Esteban Domingo; Vincent Soriano
Prevalence and genetic heterogeneity of the reverse transcriptase T69S-S-X insertion in pretreated HIV-infected patients.
Intervirology 2001;44(6):339-43.
2001: Esteban Domingo; Antonio Mas; Eloísa Yuste; Nonia Pariente; Saleta Sierra; M Gutiérrez-Riva; Luis Menéndez-Arias
Virus population dynamics, fitness variations and the control of viral disease: an update.
Progress in drug research. Fortschritte der Arzneimittelforschung. Progrès des recherches pharmaceutiques 2001;57():77-115.
2001: Mario A Fares; Andrés Moya; Cristina Escarmís; Eric Baranowski; Esteban Domingo; Eladio Barrio
Evidence for positive selection in the capsid protein-coding region of the foot-and-mouth disease virus (FMDV) subjected to experimental passage regimens.
Molecular biology and evolution 2001;18(1):10-21.
2000: Antonio Mas; M Parera; Carlos Briones; V Soriano; Miguel Angel Martínez; Esteban Domingo; Luis Menéndez-Arias
Role of a dipeptide insertion between codons 69 and 70 of HIV-1 reverse transcriptase in the mechanism of AZT resistance.
The EMBO journal 2000;19(21):5752-61.
2000: Eloísa Yuste; Cecilio López-Galíndez; Esteban Domingo
Unusual distribution of mutations associated with serial bottleneck passages of human immunodeficiency virus type 1.
Journal of virology 2000;74(20):9546-52.
2000: Saleta Sierra; Mercedes Dávila; Pedro R Lowenstein; Esteban Domingo
Response of foot-and-mouth disease virus to increased mutagenesis: influence of viral load and fitness in loss of infectivity.
Journal of virology 2000;74(18):8316-23.
2000: Wendy F Ochoa; Susana G Kalko; Mauricio G Mateu; P Gomes; David Andreu; Esteban Domingo; Ignacio Fita; Nuria Verdaguer
A multiply substituted G-H loop from foot-and-mouth disease virus in complex with a neutralizing antibody: a role for water molecules.
The Journal of general virology 2000;81(Pt 6):1495-505.
2000: Esteban Domingo
Viruses at the edge of adaptation.
Virology 2000;270(2):251-3.
2000: Esteban Domingo; Eric Baranowski; J I Nuñez; Carmen M Ruiz-Jarabo; Saleta Sierra; Nicolás Molina; Francisco Sobrino
[Quasispecies and molecular evolution of viruses].
Revue scientifique et technique (International Office of Epizootics) 2000;19(1):55-63.
2000: Carmen M Ruiz-Jarabo; Armando Arias; Eric Baranowski; Cristina Escarmís; Esteban Domingo
Memory in viral quasispecies.
Journal of virology 2000;74(8):3543-7.
2000: Eric Baranowski; Carmen M Ruiz-Jarabo; Noemí Sevilla; David Andreu; E Beck; Esteban Domingo
Cell recognition by foot-and-mouth disease virus that lacks the RGD integrin-binding motif: flexibility in aphthovirus receptor usage.
Journal of virology 2000;74(4):1641-7.
2000: ML Valero; JA Camarero; T Haack; Mauricio G Mateu; Esteban Domingo; Ernest Giralt; David Andreu
Native-like cyclic peptide models of a viral antigenic site: finding a balance between rigidity and flexibility.
Journal of molecular recognition : JMR 2000;13(1):5-13.
2000: Carlos Briones; Antonio Mas; G Gómez-Mariano; C Altisent; Luis Menéndez-Arias; Vincent Soriano; Esteban Domingo
Dynamics of dominance of a dipeptide insertion in reverse transcriptase of HIV-1 from patients subjected to prolonged therapy.
Virus research 2000;66(1):13-26.
1999: M Toja; Cristina Escarmís; Esteban Domingo
Genomic nucleotide sequence of a foot-and-mouth disease virus clone and its persistent derivatives. Implications for the evolution of viral quasispecies during a persistent infection.
Virus research 1999;64(2):161-71.
1999: Esteban Domingo; Nuria Verdaguer; Wendy F Ochoa; Carmen M Ruiz-Jarabo; Noemí Sevilla; Eric Baranowski; Mauricio G Mateu; Ignacio Fita
Biochemical and structural studies with neutralizing antibodies raised against foot-and-mouth disease virus.
Virus research 1999;62(2):169-75.
1999: Carmen M Ruiz-Jarabo; Noemí Sevilla; Mercedes Dávila; Gema Gómez-Mariano; Eric Baranowski; Esteban Domingo
Antigenic properties and population stability of a foot-and-mouth disease virus with an altered Arg-Gly-Asp receptor-recognition motif.
The Journal of general virology 1999;80 ( Pt 8)():1899-909.
1999: Isabel Olivares; V Sánchez-Merino; M A Martínez; Esteban Domingo; Cecilio López-Galíndez; Luis Menéndez-Arias
Second-site reversion of a human immunodeficiency virus type 1 reverse transcriptase mutant that restores enzyme function and replication capacity.
Journal of virology 1999;73(8):6293-8.
1999: Mónica Gutiérrez-Rivas; A Ibáñez; Miguel Angel Martínez; Esteban Domingo; Luis Menéndez-Arias
Mutational analysis of Phe160 within the "palm" subdomain of human immunodeficiency virus type 1 reverse transcriptase.
Journal of molecular biology 1999;290(3):615-25.
1999: Isabel S Novella; C L Hershey; C Escarmis; Esteban Domingo; John J Holland
Lack of evolutionary stasis during alternating replication of an arbovirus in insect and mammalian cells.
Journal of molecular biology 1999;287(3):459-65.
1999: Eloísa Yuste; S Sánchez-Palomino; Concepcion Casado; Esteban Domingo; Cecilio López-Galíndez
Drastic fitness loss in human immunodeficiency virus type 1 upon serial bottleneck events.
Journal of virology 1999;73(4):2745-51.
1999: Nuria Verdaguer; Guy Schoehn; Wendy F Ochoa; Ignacio Fita; S Brookes; A King; Esteban Domingo; Mauricio G Mateu; D Stuart; Elizabeth A Hewat
Flexibility of the major antigenic loop of foot-and-mouth disease virus bound to a Fab fragment of a neutralising antibody: structure and neutralisation.
Virology 1999;255(2):260-8.
1999: Isabel S Novella; J Quer; Esteban Domingo; John J Holland
Exponential fitness gains of RNA virus populations are limited by bottleneck effects.
Journal of virology 1999;73(2):1668-71.
1999: Cristina Escarmís; Mercedes Dávila; Esteban Domingo
Multiple molecular pathways for fitness recovery of an RNA virus debilitated by operation of Muller's ratchet.
Journal of molecular biology 1999;285(2):495-505.
1999: Eric Baranowski; Carmen M Ruiz-Jarabo; C Escarmis; Esteban Domingo
[Variability and development of viral populations: assessment and implications].
Médecine tropicale : revue du Corps de santé colonial 1999;59(4 Pt 2):430-4.
1999: Miguel E Quiñones-Mateu; Esteban Domingo
Nucleotide diversity in three different genomic regions of Venezuelan HIV type 1 isolates: a subtyping update.
AIDS research and human retroviruses 1999;15(1):73-9.
1998: Mario A Fares; Eladio Barrio; N Becerra; Cristina Escarmís; Esteban Domingo; Andrés Moya
The foot-and-mouth disease RNA virus as a model in experimental phylogenetics.
International microbiology : the official journal of the Spanish Society for Microbiology 1998;1(4):311-8.
1998: Noemí Sevilla; Carmen M Ruiz-Jarabo; Gema Gómez-Mariano; Eric Baranowski; Esteban Domingo
An RNA virus can adapt to the multiplicity of infection.
The Journal of general virology 1998;79 ( Pt 12)():2971-80.
1998: Cristina Escarmís; E C Carrillo; M Ferrer; J F Arriaza; N Lopez; C Tami; Nuria Verdaguer; Esteban Domingo; M T Franze-Fernández
Rapid selection in modified BHK-21 cells of a foot-and-mouth disease virus variant showing alterations in cell tropism.
Journal of virology 1998;72(12):10171-9.
1998: Esteban Domingo; Eric Baranowski; Carmen M Ruiz-Jarabo; Ana Montserrat Martín-Hernández; J C Sáiz; Cristina Escarmís
Quasispecies structure and persistence of RNA viruses.
Emerging infectious diseases 1998;4(4):521-7.
1998: Miguel E Quiñones-Mateu; Antonio Mas; T Lain de Lera; V Soriano; José Alcamí; M M Lederman; Esteban Domingo
LTR and tat variability of HIV-1 isolates from patients with divergent rates of disease progression.
Virus research 1998;57(1):11-20.
1998: Eric Baranowski; Noemí Sevilla; Nuria Verdaguer; Carmen M Ruiz-Jarabo; E Beck; Esteban Domingo
Multiple virulence determinants of foot-and-mouth disease virus in cell culture.
Journal of virology 1998;72(8):6362-72.
1998: Esteban Domingo
Quasispecies and the implications for virus persistence and escape.
Clinical and diagnostic virology 1998;10(2-3):97-101.
1998: Luis Menéndez-Arias; Antonio Mas; Esteban Domingo
Cytotoxic T-lymphocyte responses to HIV-1 reverse transcriptase (review).
Viral immunology 1998;11(4):167-81.
1998: Esteban Domingo; Cristina Escarmís; Noemí Sevilla; Eric Baranowski
Population dynamics in the evolution of RNA viruses.
Advances in experimental medicine and biology 1998;440():721-7.
1998: Mauricio G Mateu; Cristina Escarmís; Esteban Domingo
Mutational analysis of discontinuous epitopes of foot-and-mouth disease virus using an unprocessed capsid protomer precursor.
Virus research 1998;53(1):27-37.
1998: J Holland; Esteban Domingo
Origin and evolution of viruses.
Virus genes 1998;16(1):13-21.
1998: Nuria Verdaguer; Noemí Sevilla; M L Valero; D Stuart; Emiliana Brocchi; David Andreu; E Giralt; Esteban Domingo; Mauricio G Mateu; Ignacio Fita
A similar pattern of interaction for different antibodies with a major antigenic site of foot-and-mouth disease virus: implications for intratypic antigenic variation.
Journal of virology 1998;72(1):739-48.
1997: Nuria Verdaguer; Ignacio Fita; Esteban Domingo; Mauricio G Mateu
Efficient neutralization of foot-and-mouth disease virus by monovalent antibody binding.
Journal of virology 1997;71(12):9813-6.
1997: Miguel E Quiñones-Mateu; V Soriano; Esteban Domingo; Luis Menéndez-Arias
Characterization of the reverse transcriptase of a human immunodeficiency virus type 1 group O isolate.
Virology 1997;236(2):364-73.
1997: M A Martínez; Nuria Verdaguer; Mauricio G Mateu; Esteban Domingo
Evolution subverting essentiality: dispensability of the cell attachment Arg-Gly-Asp motif in multiply passaged foot-and-mouth disease virus.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(13):6798-802.
1997: T Haack; JA Camarero; Xavier Roig; Mauricio G Mateu; Esteban Domingo; David Andreu; Ernest Giralt
A cyclic disulfide peptide reproduces in solution the main structural features of a native antigenic site of foot-and-mouth disease virus.
International journal of biological macromolecules 1997;20(3):209-19.
1997: Esteban Domingo
Rapid evolution of viral RNA genomes.
The Journal of nutrition 1997;127(5 Suppl):958S-961S.
1997: C H Lee; D L Gilbertson; Isabel S Novella; R Huerta; Esteban Domingo; John J Holland
Negative effects of chemical mutagenesis on the adaptive behavior of vesicular stomatitis virus.
Journal of virology 1997;71(5):3636-40.
1997: Elizabeth A Hewat; Nuria Verdaguer; Ignacio Fita; W Blakemore; S Brookes; A King; J Newman; Esteban Domingo; Mauricio G Mateu; D I Stuart
Structure of the complex of an Fab fragment of a neutralizing antibody with foot-and-mouth disease virus: positioning of a highly mobile antigenic loop.
The EMBO journal 1997;16(7):1492-500.
1997: Oscar Taboga; Cecilia Tami; Elisa Carrillo; José Ignacio Núñez; A Rodríguez; J C Saíz; Esther Blanco; ML Valero; Xavier Roig; JA Camarero; David Andreu; Mauricio G Mateu; Ernest Giralt; Esteban Domingo; Francisco Sobrino; Eduardo L Palma
A large-scale evaluation of peptide vaccines against foot-and-mouth disease: lack of solid protection in cattle and isolation of escape mutants.
Journal of virology 1997;71(4):2606-14.
1997: Ana Montserrat Martín-Hernández; Mónica Gutiérrez-Rivas; Esteban Domingo; Luis Menéndez-Arias
Mispair extension fidelity of human immunodeficiency virus type 1 reverse transcriptases with amino acid substitutions affecting Tyr115.
Nucleic acids research 1997;25(7):1383-9.
1997: A Holguín; J Hernández; M A Martínez; Mauricio G Mateu; Esteban Domingo
Differential restrictions on antigenic variation among antigenic sites of foot-and-mouth disease virus in the absence of antibody selection.
The Journal of general virology 1997;78 ( Pt 3)():601-9.
1997: Esteban Domingo; John J Holland
RNA virus mutations and fitness for survival.
Annual review of microbiology 1997;51():151-78.
1997: Esteban Domingo; Luis Menéndez-Arias; Miguel E Quiñones-Mateu; A Holguín; Mónica Gutiérrez-Rivas; Miguel Angel Martínez; J Quer; Isabel S Novella; John J Holland
Viral quasispecies and the problem of vaccine-escape and drug-resistant mutants.
Progress in drug research. Fortschritte der Arzneimittelforschung. Progrès des recherches pharmaceutiques 1997;48():99-128.
1997: Esteban Domingo
RNA virus evolution, population dynamics, and nutritional status.
Biological trace element research 1997;56(1):23-30.
1996: J Quer; Ramón Huerta; Isabel S Novella; L Tsimring; Esteban Domingo; John J Holland
Reproducible nonlinear population dynamics and critical points during replicative competitions of RNA virus quasispecies.
Journal of molecular biology 1996;264(3):465-71.
1996: Cristina Escarmís; Mercedes Dávila; N Charpentier; A Bracho; Andrés Moya; Esteban Domingo
Genetic lesions associated with Muller's ratchet in an RNA virus.
Journal of molecular biology 1996;264(2):255-67.
1996: Noemí Sevilla; Nuria Verdaguer; Esteban Domingo
Antigenically profound amino acid substitutions occur during large population passages of foot-and-mouth disease virus.
Virology 1996;225(2):400-5.
1996: Isabel S Novella; Santiago F Elena; Andrés Moya; Esteban Domingo; John J Holland
Repeated transfer of small RNA virus populations leading to balanced fitness with infrequent stochastic drift.
Molecular & general genetics : MGG 1996;252(6):733-8.
1996: Noemí Sevilla; Esteban Domingo
Evolution of a persistent aphthovirus in cytolytic infections: partial reversion of phenotypic traits accompanied by genetic diversification.
Journal of virology 1996;70(10):6617-24.
1996: N Charpentier; Mercedes Dávila; Esteban Domingo; Cristina Escarmís
Long-term, large-population passage of aphthovirus can generate and amplify defective noninterfering particles deleted in the leader protease gene.
Virology 1996;223(1):10-8.
1996: Isabel S Novella; M Cilnis; Santiago F Elena; J Kohn; Andrés Moya; Esteban Domingo; John J Holland
Large-population passages of vesicular stomatitis virus in interferon-treated cells select variants of only limited resistance.
Journal of virology 1996;70(9):6414-7.
1996: Juan-Carlos Sáiz; Esteban Domingo
Virulence as a positive trait in viral persistence.
Journal of virology 1996;70(9):6410-3.
1996: A M Martín-Hernández; Esteban Domingo; Luis Menéndez-Arias
Human immunodeficiency virus type 1 reverse transcriptase: role of Tyr115 in deoxynucleotide binding and misinsertion fidelity of DNA synthesis.
The EMBO journal 1996;15(16):4434-42.
1996: Miguel E Quiñones-Mateu; A Holguín; J Dopazo; I Nájera; Esteban Domingo
Point mutant frequencies in the pol gene of human immunodeficiency virus type 1 are two- to threefold lower than those of env.
AIDS research and human retroviruses 1996;12(12):1117-28.
1996: Miguel E Quiñones-Mateu; A Holguín; V Soriano; Esteban Domingo
env gene diversity of HIV type 1 isolates from Spain.
AIDS research and human retroviruses 1996;12(10):955-7.
1996: Esteban Domingo; Cristina Escarmís; Noemí Sevilla; Andrés Moya; Santiago F Elena; J Quer; Isabel S Novella; John J Holland
Basic concepts in RNA virus evolution.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(8):859-64.
1996: Mauricio G Mateu; M L Valero; David Andreu; Esteban Domingo
Systematic replacement of amino acid residues within an Arg-Gly-Asp-containing loop of foot-and-mouth disease virus and effect on cell recognition.
The Journal of biological chemistry 1996;271(22):12814-9.
1996: Santiago F Elena; F González-Candelas; Isabel S Novella; E A Duarte; D K Clarke; Esteban Domingo; John J Holland; Andrés Moya
Evolution of fitness in experimental populations of vesicular stomatitis virus.
Genetics 1996;142(3):673-9.
1996: D A Feigelstock; Mauricio G Mateu; M L Valero; David Andreu; Esteban Domingo; Eduardo L Palma
Emerging foot-and-mouth disease virus variants with antigenically critical amino acid substitutions predicted by model studies using reference viruses.
Vaccine 1996;14(2):97-102.
1996: J Hernández; M L Valero; David Andreu; Esteban Domingo; Mauricio G Mateu
Antibody and host cell recognition of foot-and-mouth disease virus (serotype C) cleaved at the Arg-Gly-Asp (RGD) motif: a structural interpretation.
The Journal of general virology 1996;77 ( Pt 2 )():257-64.
1996: Encarnación Martínez-Salas; M P Regalado; Esteban Domingo
Identification of an essential region for internal initiation of translation in the aphthovirus internal ribosome entry site and implications for viral evolution.
Journal of virology 1996;70(2):992-8.
1995: Isabel S Novella; D K Clarke; J Quer; E A Duarte; C H Lee; Scott C Weaver; Santiago F Elena; Andrés Moya; Esteban Domingo; John J Holland
Extreme fitness differences in mammalian and insect hosts after continuous replication of vesicular stomatitis virus in sandfly cells.
Journal of virology 1995;69(11):6805-9.
1995: Encarnación Martínez-Salas; Esteban Domingo
Effect of expression of the aphthovirus protease 3C on viral infection and gene expression.
Virology 1995;212(1):111-20.
1995: Mauricio G Mateu; David Andreu; Esteban Domingo
Antibodies raised in a natural host and monoclonal antibodies recognize similar antigenic features of foot-and-mouth disease virus.
Virology 1995;210(1):120-7.
1995: Isabel S Novella; E A Duarte; Santiago F Elena; Andrés Moya; Esteban Domingo; John J Holland
Exponential increases of RNA virus fitness during large population transmissions.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(13):5841-4.
1995: Isabel S Novella; Santiago F Elena; Andrés Moya; Esteban Domingo; John J Holland
Size of genetic bottlenecks leading to virus fitness loss is determined by mean initial population fitness.
Journal of virology 1995;69(5):2869-72.
1995: Miguel E Quiñones-Mateu; J Dopazo; J A Esté; T R Rota; Esteban Domingo
Molecular characterization of human immunodeficiency virus type 1 isolates from Venezuela.
AIDS research and human retroviruses 1995;11(5):605-16.
1995: Cristina Escarmís; J Dopazo; Mercedes Dávila; Eduardo L Palma; Esteban Domingo
Large deletions in the 5'-untranslated region of foot-and-mouth disease virus of serotype C.
Virus research 1995;35(2):155-67.
1995: Mauricio G Mateu; Julio A Camarero; Ernest Giralt; David Andreu; Esteban Domingo
Direct evaluation of the immunodominance of a major antigenic site of foot-and-mouth disease virus in a natural host.
Virology 1995;206(1):298-306.
1995: M L Valero; Julio A Camarero; A Adeva; Nuria Verdaguer; Ignacio Fita; Mauricio G Mateu; Esteban Domingo; Ernest Giralt; David Andreu
Cyclic peptides as conformationally restricted models of viral antigens: application to foot-and-mouth disease virus.
Biomedical peptides, proteins & nucleic acids : structure, synthesis & biological activity 1995;1(3):133-40.
1995: Esteban Domingo; Mauricio G Mateu; Cristina Escarmís; Encarnación Martínez-Salas; David Andreu; Ernest Giralt; Nuria Verdaguer; Ignacio Fita
Molecular evolution of aphthoviruses.
Virus genes 1995;11(2-3):197-207.
1995: B Borrego; Julio A Camarero; Mauricio G Mateu; Esteban Domingo
A highly divergent antigenic site of foot-and-mouth disease virus retains its immunodominance.
Viral immunology 1995;8(1):11-8.
1995: I Nájera; A Holguín; Miguel E Quiñones-Mateu; M Angeles Muñoz-Fernández; R Nájera; Cecilio López-Galíndez; Esteban Domingo
Pol gene quasispecies of human immunodeficiency virus: mutations associated with drug resistance in virus from patients undergoing no drug therapy.
Journal of virology 1995;69(1):23-31.
1994: E A Duarte; Isabel S Novella; Scott C Weaver; Esteban Domingo; S Wain-Hobson; D K Clarke; Andrés Moya; Santiago F Elena; J C de la Torre; John J Holland
RNA virus quasispecies: significance for viral disease and epidemiology.
Infectious agents and disease 1994;3(4):201-14.
1994: E A Duarte; Isabel S Novella; S Ledesma; D K Clarke; Andrés Moya; Santiago F Elena; Esteban Domingo; John J Holland
Subclonal components of consensus fitness in an RNA virus clone.
Journal of virology 1994;68(7):4295-301.
1994: Juan-Carlos Sáiz; J Cairó; Miguel Medina; Douwe Zuidema; C Abrams; G J Belsham; Esteban Domingo; Just M Vlak
Unprocessed foot-and-mouth disease virus capsid precursor displays discontinuous epitopes involved in viral neutralization.
Journal of virology 1994;68(7):4557-64.
1994: D K Clarke; E A Duarte; Santiago F Elena; Andrés Moya; Esteban Domingo; J Holland
The red queen reigns in the kingdom of RNA viruses.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(11):4821-4.
1994: A M Martín Hernández; E C Carrillo; Noemí Sevilla; Esteban Domingo
Rapid cell variation can determine the establishment of a persistent viral infection.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(9):3705-9.
1994: Mauricio G Mateu; J Hernández; M A Martínez; D Feigelstock; Susan M Lea; J J Pérez; Ernest Giralt; David Stuart; Eduardo L Palma; Esteban Domingo
Antigenic heterogeneity of a foot-and-mouth disease virus serotype in the field is mediated by very limited sequence variation at several antigenic sites.
Journal of virology 1994;68(3):1407-17.
1994: Susan M Lea; J Hernández; W Blakemore; E Brocchi; S Curry; Esteban Domingo; Elizabeth Fry; R Abu-Ghazaleh; A King; J Newman
The structure and antigenicity of a type C foot-and-mouth disease virus.
Structure (London, England : 1993) 1994;2(2):123-39.
1993: Esteban Domingo; J Díez; M A Martínez; J Hernández; A Holguín; B Borrego; Mauricio G Mateu
New observations on antigenic diversification of RNA viruses. Antigenic variation is not dependent on immune selection.
The Journal of general virology 1993;74 ( Pt 10)():2039-45.
1993: B Borrego; Isabel S Novella; Ernest Giralt; David Andreu; Esteban Domingo
Distinct repertoire of antigenic variants of foot-and-mouth disease virus in the presence or absence of immune selection.
Journal of virology 1993;67(10):6071-9.
1993: Isabel S Novella; B Borrego; Mauricio G Mateu; Esteban Domingo; Ernest Giralt; David Andreu
Use of substituted and tandem-repeated peptides to probe the relevance of the highly conserved RGD tripeptide in the immune response against foot-and-mouth disease virus.
FEBS letters 1993;330(3):253-9.
1993: Julio A Camarero; David Andreu; J J Cairó; Mauricio G Mateu; Esteban Domingo; Ernest Giralt
Cyclic disulfide model of the major antigenic site of serotype-C foot-and-mouth disease virus. Synthetic, conformational and immunochemical studies.
FEBS letters 1993;328(1-2):159-64.
1993: Encarnación Martínez-Salas; Juan-Carlos Sáiz; Mercedes Dávila; G J Belsham; Esteban Domingo
A single nucleotide substitution in the internal ribosome entry site of foot-and-mouth disease virus leads to enhanced cap-independent translation in vivo.
Journal of virology 1993;67(7):3748-55.
1993: E A Duarte; D K Clarke; Andrés Moya; Santiago F Elena; Esteban Domingo; J Holland
Many-trillionfold amplification of single RNA virus particles fails to overcome the Muller's ratchet effect.
Journal of virology 1993;67(6):3620-3.
1993: S Sánchez-Palomino; J M Rojas; M A Martínez; E M Fenyö; R Nájera; Esteban Domingo; Cecilio López-Galíndez
Dilute passage promotes expression of genetic and phenotypic variants of human immunodeficiency virus type 1 in cell culture.
Journal of virology 1993;67(5):2938-43.
1993: D K Clarke; E A Duarte; Andrés Moya; Santiago F Elena; Esteban Domingo; J Holland
Genetic bottlenecks and population passages cause profound fitness differences in RNA viruses.
Journal of virology 1993;67(1):222-8.
1992: D A Steinhauer; Esteban Domingo; John J Holland
Lack of evidence for proofreading mechanisms associated with an RNA virus polymerase.
Gene 1992;122(2):281-8.
1992: D Feigelstock; Mauricio G Mateu; M E Piccone; F De Simone; Emiliana Brocchi; Esteban Domingo; Eduardo L Palma
Extensive antigenic diversification of foot-and-mouth disease virus by amino acid substitutions outside the major antigenic site.
The Journal of general virology 1992;73 ( Pt 12)():3307-11.
1992: Cristina Escarmís; M Toja; Miguel Medina; Esteban Domingo
Modifications of the 5' untranslated region of foot-and-mouth disease virus after prolonged persistence in cell culture.
Virus research 1992;26(2):113-25.
1992: E Duarte; D Clarke; Andrés Moya; Esteban Domingo; J Holland
Rapid fitness losses in mammalian RNA virus clones due to Muller's ratchet.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(13):6015-9.
1992: Mauricio G Mateu; David Andreu; Cristina Carreño; X Roig; J J Cairó; Julio A Camarero; Ernest Giralt; Esteban Domingo
Non-additive effects of multiple amino acid substitutions on antigen-antibody recognition.
European journal of immunology 1992;22(6):1385-9.
1992: M A Martínez; J Dopazo; J Hernández; Mauricio G Mateu; Francisco Sobrino; Esteban Domingo; N J Knowles
Evolution of the capsid protein genes of foot-and-mouth disease virus: antigenic variation without accumulation of amino acid substitutions over six decades.
Journal of virology 1992;66(6):3557-65.
1992: Esteban Domingo
Genetic variation and quasi-species.
Current opinion in genetics & development 1992;2(1):61-3.
1992: Cristina Carreño; X Roig; J Cairo; Julio A Camarero; Mauricio G Mateu; Esteban Domingo; Ernest Giralt; David Andreu
Studies on antigenic variability of C strains of foot-and-mouth disease virus by means of synthetic peptides and monoclonal antibodies.
International journal of peptide and protein research 1992;39(1):41-7.
1992: J Hernández; M A Martínez; E Rocha; Esteban Domingo; Mauricio G Mateu
Generation of a subtype-specific neutralization epitope in foot-and-mouth disease virus of a different subtype.
The Journal of general virology 1992;73 ( Pt 1)():213-6.
1992: Esteban Domingo; John J Holland
Complications of RNA heterogeneity for the engineering of virus vaccines and antiviral agents.
Genetic engineering 1992;14():13-31.
1992: Esteban Domingo; C Escarmis; M A Martinez; E Martinez-Salas; Mauricio G Mateu
Foot-and-mouth disease virus populations are quasispecies.
Current topics in microbiology and immunology 1992;176():33-47.
1991: M A Martínez; J Hernández; M E Piccone; Eduardo L Palma; Esteban Domingo; N Knowles; Mauricio G Mateu
Two mechanisms of antigenic diversification of foot-and-mouth disease virus.
Virology 1991;184(2):695-706.
1991: M A Martínez; C Carrillo; F González-Candelas; Andrés Moya; Esteban Domingo; F Sobrino
Fitness alteration of foot-and-mouth disease virus mutants: measurement of adaptability of viral quasispecies.
Journal of virology 1991;65(7):3954-7.
1990: J Díez; Mercedes Dávila; Cristina Escarmís; Mauricio G Mateu; J Dominguez; J J Pérez; Ernest Giralt; José A Melero; Esteban Domingo
Unique amino acid substitutions in the capsid proteins of foot-and-mouth disease virus from a persistent infection in cell culture.
Journal of virology 1990;64(11):5519-28.
1990: John J Holland; Esteban Domingo; J C de la Torre; D A Steinhauer
Mutation frequencies at defined single codon sites in vesicular stomatitis virus and poliovirus can be increased only slightly by chemical mutagenesis.
Journal of virology 1990;64(8):3960-2.
1990: Mauricio G Mateu; M A Martínez; Lorenzo Capucci; David Andreu; Ernest Giralt; Francisco Sobrino; Emiliana Brocchi; Esteban Domingo
A single amino acid substitution affects multiple overlapping epitopes in the major antigenic site of foot-and-mouth disease virus of serotype C.
The Journal of general virology 1990;71 ( Pt 3)():629-37.
1989: J Diez; Mauricio G Mateu; Esteban Domingo
Selection of antigenic variants of foot-and-mouth disease virus in the absence of antibodies, as revealed by an in situ assay.
The Journal of general virology 1989;70 ( Pt 12)():3281-9.
1989: John J Holland; J C de la Torre; D A Steinhauer; D Clarke; E Duarte; Esteban Domingo
Virus mutation frequencies can be greatly underestimated by monoclonal antibody neutralization of virions.
Journal of virology 1989;63(12):5030-6.
1989: Mauricio G Mateu; M A Martínez; E Rocha; David Andreu; J Parejo; Ernest Giralt; Francisco Sobrino; Esteban Domingo
Implications of a quasispecies genome structure: effect of frequent, naturally occurring amino acid substitutions on the antigenicity of foot-and-mouth disease virus.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(15):5883-7.
1989: J C de la Torre; S de la Luna; J Diez; Esteban Domingo
Resistance to foot-and-mouth disease virus mediated by trans-acting cellular products.
Journal of virology 1989;63(5):2385-7.
1989: J C de la Torre; Encarnación Martínez-Salas; J Díez; Esteban Domingo
Extensive cell heterogeneity during persistent infection with foot-and-mouth disease virus.
Journal of virology 1989;63(1):59-63.
1988: A Villaverde; Encarnación Martínez-Salas; Esteban Domingo
3D gene of foot-and-mouth disease virus. Conservation by convergence of average sequences.
Journal of molecular biology 1988;204(3):771-6.
1988: J C de la Torre; Esteban Domingo
Minimum number of cells required for reconstitution of a foot-and-mouth disease virus-carrier cell culture.
Microbiología (Madrid, Spain) 1988;4(3):161-6.
1988: Mauricio G Mateu; J L Da Silva; E Rocha; D L De Brum; A Alonso; Luis Enjuanes; Esteban Domingo; H Barahona
Extensive antigenic heterogeneity of foot-and-mouth disease virus of serotype C.
Virology 1988;167(1):113-24.
1988: J Dopazo; Francisco Sobrino; Eduardo L Palma; Esteban Domingo; A Moya
Gene encoding capsid protein VP1 of foot-and-mouth disease virus: a quasispecies model of molecular evolution.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(18):6811-5.
1988: J C de la Torre; Encarnación Martínez-Salas; J Diez; A Villaverde; F Gebauer; E Rocha; Mercedes Dávila; Esteban Domingo
Coevolution of cells and viruses in a persistent infection of foot-and-mouth disease virus in cell culture.
Journal of virology 1988;62(6):2050-8.
1988: F Gebauer; J C de la Torre; I Gomes; Mauricio G Mateu; H Barahona; B Tiraboschi; Ingrid E Bergmann; P A de Mello; Esteban Domingo
Rapid selection of genetic and antigenic variants of foot-and-mouth disease virus during persistence in cattle.
Journal of virology 1988;62(6):2041-9.
1988: M E Piccone; G Kaplan; Luis D Giavedoni; Esteban Domingo; Eduardo L Palma
VP1 of serotype C foot-and-mouth disease viruses: long-term conservation of sequences.
Journal of virology 1988;62(4):1469-73.
1987: Mauricio G Mateu; E Rocha; O Vicente; F Vayreda; C Navalpotro; David Andreu; Enrique Pedroso; Ernest Giralt; Luis Enjuanes; Esteban Domingo
Reactivity with monoclonal antibodies of viruses from an episode of foot-and-mouth disease.
Virus research 1987;8(3):261-74.
1986: Francisco Sobrino; Eduardo L Palma; E Beck; Mercedes Dávila; J C de la Torre; P Negro; N Villanueva; Juan Ortín; Esteban Domingo
Fixation of mutations in the viral genome during an outbreak of foot-and-mouth disease: heterogeneity and rate variations.
Gene 1986;50(1-3):149-59.
1985: J C de la Torre; Mercedes Dávila; Francisco Sobrino; Juan Ortín; Esteban Domingo
Establishment of cell lines persistently infected with foot-and-mouth disease virus.
Virology 1985;145(1):24-35.
1985: C López-Galindez; Juan Ortín; Esteban Domingo; L del Rio; P Pérez-Breña; R Nájera
Heterogeneity among influenza H3N2 isolates recovered during an outbreak. Brief report.
Archives of virology 1985;85(1-2):139-44.
1985: Esteban Domingo; E Martínez-Salas; Francisco Sobrino; J C de la Torre; Agustín Portela; Juan Ortín; C López-Galindez; P Pérez-Breña; N Villanueva; R Nájera
The quasispecies (extremely heterogeneous) nature of viral RNA genome populations: biological relevance--a review.
Gene 1985;40(1):1-8.
1983: Juan Ortín; C Martínez; L del Río; Mercedes Dávila; C López-Galíndez; N Villanueva; Esteban Domingo
Evolution of the nucleotide sequence of influenza virus RNA segment 7 during drift of the H3N2 subtype.
Gene 1983;23(2):233-9.
1983: N Villanueva; Mercedes Dávila; Juan Ortín; Esteban Domingo
Molecular cloning of cDNA from foot-and-mouth disease virus C1-Santa Pau (C-S8). Sequence of protein-VP1-coding segment.
Gene 1983;23(2):185-94.
1983: Francisco Sobrino; Mercedes Dávila; Juan Ortín; Esteban Domingo
Multiple genetic variants arise in the course of replication of foot-and-mouth disease virus in cell culture.
Virology 1983;128(2):310-8.
1980: Juan Ortín; R Nájera; C López; Mercedes Dávila; Esteban Domingo
Genetic variability of Hong Kong (H3N2) influenza viruses: spontaneous mutations and their location in the viral genome.
Gene 1980;11(3-4):319-31.
1980: Esteban Domingo; Mercedes Dávila; Juan Ortín
Nucleotide sequence heterogeneity of the RNA from a natural population of foot-and-mouth-disease virus.
Gene 1980;11(3-4):333-46.