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Ken Donaldson

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Ken Donaldson; Rodger Duffin; Jeremy P Langrish; Mark R Miller; Nicholas L Mills; Craig A Poland; Jennifer Raftis; Anoop Shah; Catherine A Shaw; David E Newby
Nanoparticles and the cardiovascular system: a critical review.
Wan-Seob Cho; Kenneth Dart; Ken Donaldson; Dominika J Nowakowska; Xiaozhong Zheng; Sarah E M Howie
Adjuvanticity and toxicity of cobalt oxide nanoparticles as an alternative vaccine adjuvant.
Anja Schinwald; David A Schultz; Fiona Byrne; Janet C Dickerson; James R Glass; Chris E Jeffree; William MacNee; Dania Movia; Fiona A Murphy; Craig A Poland; Adriele Prina Mello; Ken Donaldson
The threshold length for fiber-induced acute pleural inflammation: shedding light on the early events in asbestos-induced mesothelioma.

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All Publications

2013: Ken Donaldson; Rodger Duffin; Jeremy P Langrish; Mark R Miller; Nicholas L Mills; Craig A Poland; Jennifer Raftis; Anoop Shah; Catherine A Shaw; David E Newby
Nanoparticles and the cardiovascular system: a critical review.
Nanomedicine (London, England) 2013;8(3):403-23.
2012: Wan-Seob Cho; Kenneth Dart; Ken Donaldson; Dominika J Nowakowska; Xiaozhong Zheng; Sarah E M Howie
Adjuvanticity and toxicity of cobalt oxide nanoparticles as an alternative vaccine adjuvant.
Nanomedicine (London, England) 2012;7(10):1495-505.
2012: Anja Schinwald; David A Schultz; Fiona Byrne; Janet C Dickerson; James R Glass; Chris E Jeffree; William MacNee; Dania Movia; Fiona A Murphy; Craig A Poland; Adriele Prina Mello; Ken Donaldson
The threshold length for fiber-induced acute pleural inflammation: shedding light on the early events in asbestos-induced mesothelioma.
Toxicological sciences : an official journal of the Society of Toxicology 2012;128(2):461-70.
2012: Wan-Seob Cho; Mark Bradley; Rodger Duffin; William MacNee; Ian L Megson; Craig A Poland; Frank Thielbeer; C Lang Tran; Ken Donaldson
Zeta potential and solubility to toxic ions as mechanisms of lung inflammation caused by metal/metal oxide nanoparticles.
Toxicological sciences : an official journal of the Society of Toxicology 2012;126(2):469-77.
2012: Jeremy P Langrish; Matthew M Y Lee; Jing Li; Liming Li; Xi Li; Mark R Miller; Nicholas L Mills; David E Newby; Shengfeng Wang; Gareth D Barnes; Nicholas A Boon; Flemming R Cassee; Ken Donaldson; Lixin Jiang
Reducing personal exposure to particulate air pollution improves cardiovascular health in patients with coronary heart disease.
Environmental health perspectives 2012;120(3):367-72.
2012: W-S Cho; M Bradley; R Duffin; S E M Howie; William MacNee; I L Megson; Ken Donaldson
NiO and Co3O4 nanoparticles induce lung DTH-like responses and alveolar lipoproteinosis.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2012;39(3):546-57.
2012: Wan-Seob Cho; Mark Bradley; Rodger Duffin; Albert Duschl; William MacNee; Ian L Megson; Gertie J Oostingh; Craig A Poland; Ken Donaldson
Differential pro-inflammatory effects of metal oxide nanoparticles and their soluble ions in vitro and in vivo; zinc and copper nanoparticles, but not their ions, recruit eosinophils to the lungs.
Nanotoxicology 2012;6(1):22-35.
2012: Anja Schinwald; Alan Jones; William MacNee; Fiona A Murphy; Ken Donaldson
Graphene-based nanoplatelets: a new risk to the respiratory system as a consequence of their unusual aerodynamic properties.
ACS nano 2012;6(1):736-46.
2012: Craig A R Auchinvole; Ken Donaldson; Venkatesh Mallikarjun; Catherine McGuinnes; Hamish McNab; Patricia Richardson; Colin J Campbell
Monitoring intracellular redox potential changes using SERS nanosensors.
ACS nano 2012;6(1):888-96.
2012: Anja Schinwald; Tanya Chernova; Ken Donaldson
Use of silver nanowires to determine thresholds for fibre length-dependent pulmonary inflammation and inhibition of macrophage migration in vitro.
Particle and fibre toxicology 2012;9():47.
2012: Anja Schinwald; Ken Donaldson
Use of back-scatter electron signals to visualise cell/nanowires interactions in vitro and in vivo; frustrated phagocytosis of long fibres in macrophages and compartmentalisation in mesothelial cells in vivo.
Particle and fibre toxicology 2012;9():34.
2012: Ken Donaldson; Anthony Seaton
A short history of the toxicology of inhaled particles.
Particle and fibre toxicology 2012;9():13.
2012: Fiona A Murphy; Craig A Poland; Anja Schinwald; Ken Donaldson
The mechanism of pleural inflammation by long carbon nanotubes: interaction of long fibres with macrophages stimulates them to amplify pro-inflammatory responses in mesothelial cells.
Particle and fibre toxicology 2012;9():8.
2011: Nicholas L Mills; Thomas Sandstrom; Jon Beveridge; Anders Blomberg; john boere; Nicholas A Boon; Flemming R Cassee; Ken Donaldson; Rodger Duffin; Laura Flint; Paul H B Fokkens; Patrick W F Hadoke; Andrew J Lucking; Mark R Miller; David E Newby
Combustion-derived nanoparticulate induces the adverse vascular effects of diesel exhaust inhalation.
European heart journal 2011;32(21):2660-71.
2011: Fiona A Murphy; Craig A Poland; Rodger Duffin; Khuloud T Al-Jamal; Hanene Ali-Boucetta; Antonio Nunes; Fiona Byrne; Adriele Prina Mello; Yuri Volkov; Shouping Li; Stephen J Mather; Alberto Bianco; Maurizio Prato; William MacNee; William A Wallace; Kostas Kostarelos; Ken Donaldson
Length-dependent retention of carbon nanotubes in the pleural space of mice initiates sustained inflammation and progressive fibrosis on the parietal pleura.
The American journal of pathology 2011;178(6):2587-600.
2011: Catherine A Shaw; Caroline M Tabor; Ken Donaldson; Rodger Duffin; Mark R Miller; David E Newby; Sarah Robertson; Patrick W F Hadoke
Diesel exhaust particulate--exposed macrophages cause marked endothelial cell activation.
American journal of respiratory cell and molecular biology 2011;44(6):840-51.
2011: Nicholas L Mills; Alexander E Finlayson; Manuel C Gonzalez; Håkan Törnqvist; Stefan Barath; Elen Vink; Colin Goudie; Jeremy P Langrish; Stefan Söderberg; Nicholas A Boon; Keith A A Fox; Ken Donaldson; Thomas Sandström; Anders Blomberg; David E Newby
Diesel exhaust inhalation does not affect heart rhythm or heart rate variability.
Heart (British Cardiac Society) 2011;97(7):544-50.
2011: Frank Thielbeer; Ken Donaldson; Mark Bradley
Zeta potential mediated reaction monitoring on nano and microparticles.
Bioconjugate chemistry 2011;22(2):144-50.
2011: Catherine McGuinnes; Rodger Duffin; Simon Brown; Nicholas L Mills; Ian L Megson; William MacNee; Shonna Johnston; Sen Lin Lu; Lang Tran; Rufia Li; Xue Wang; David E Newby; Ken Donaldson
Surface derivatization state of polystyrene latex nanoparticles determines both their potency and their mechanism of causing human platelet aggregation in vitro.
Toxicological sciences : an official journal of the Society of Toxicology 2011;119(2):359-68.
2011: Wan-Seob Cho; Mark Bradley; Rodger Duffin; Sarah E M Howie; William MacNee; Ian L Megson; Chris J Scotton; William A H Wallace; Ken Donaldson
Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes.
Particle and fibre toxicology 2011;8():27.
2011: Ken Donaldson; Fiona Murphy; Anja Schinwald; Rodger Duffin; Craig A Poland
Identifying the pulmonary hazard of high aspect ratio nanoparticles to enable their safety-by-design.
Nanomedicine (London, England) 2011;6(1):143-56.
2010: Ken Donaldson; Craig A Poland; Roel P F Schins
Possible genotoxic mechanisms of nanoparticles: criteria for improved test strategies.
Nanotoxicology 2010;4():414-20.
2010: Wan-Seob Cho; Rodger Duffin; Craig A Poland; Sarah E M Howie; William MacNee; Mark Bradley; Ian L Megson; Ken Donaldson
Metal oxide nanoparticles induce unique inflammatory footprints in the lung: important implications for nanoparticle testing.
Environmental health perspectives 2010;118(12):1699-706.
2009: Ken Donaldson; Craig A Poland
Nanotoxicology: new insights into nanotubes.
Nature nanotechnology 2009;4(11):708-10.
2009: Mark R Miller; Stephen J Borthwick; Catherine A Shaw; Steven G McLean; Daniel McClure; Nicholas L Mills; Rodger Duffin; Ken Donaldson; Ian L Megson; Patrick W F Hadoke; David E Newby
Direct impairment of vascular function by diesel exhaust particulate through reduced bioavailability of endothelium-derived nitric oxide induced by superoxide free radicals.
Environmental health perspectives 2009;117(4):611-6.
2009: Senlin Lu; Rodger Duffin; Craig Poland; Paul Daly; Fiona Murphy; Ellen Drost; William MacNee; Vicki Stone; Ken Donaldson
Efficacy of simple short-term in vitro assays for predicting the potential of metal oxide nanoparticles to cause pulmonary inflammation.
Environmental health perspectives 2009;117(2):241-7.
2009: Ken Donaldson
The inhalation toxicology of p-aramid fibrils.
Critical reviews in toxicology 2009;39(6):487-500.
2009: Ken Donaldson; Paul J A Borm; Vincent Castranova; Mary Gulumian
The limits of testing particle-mediated oxidative stress in vitro in predicting diverse pathologies; relevance for testing of nanoparticles.
Particle and fibre toxicology 2009;6():13.
2009: Jeremy P Langrish; Nicholas L Mills; Julian Kk Chan; Daan L A C Leseman; Robert J Aitken; Paul H B Fokkens; Flemming R Cassee; Jing Li; Ken Donaldson; David E Newby; Lixin Jiang
Beneficial cardiovascular effects of reducing exposure to particulate air pollution with a simple facemask.
Particle and fibre toxicology 2009;6():8.
2009: Magnus Lundbäck; Nicholas L Mills; Andrew Lucking; Stefan Barath; Ken Donaldson; David E Newby; Thomas Sandström; Anders Blomberg
Experimental exposure to diesel exhaust increases arterial stiffness in man.
Particle and fibre toxicology 2009;6():7.
2008: Martin J D Clift; Barbara Rothen-Rutishauser; David M Brown; Rodger Duffin; Ken Donaldson; Lorna Proudfoot; Keith Guy; Vicki Stone
The impact of different nanoparticle surface chemistry and size on uptake and toxicity in a murine macrophage cell line.
Toxicology and applied pharmacology 2008;232(3):418-27.
2008: Nicholas L Mills; Simon D Robinson; Paul H B Fokkens; Daan L A C Leseman; Mark R Miller; David Anderson; Evelyn J Freney; Mathew R Heal; Robert J Donovan; Anders Blomberg; Thomas Sandström; William MacNee; Nicholas A Boon; Ken Donaldson; David E Newby; Flemming R Cassee
Exposure to concentrated ambient particles does not affect vascular function in patients with coronary heart disease.
Environmental health perspectives 2008;116(6):709-15.
2008: Peter G Barlow; David M Brown; Ken Donaldson; Janis MacCallum; Vicki Stone
Reduced alveolar macrophage migration induced by acute ambient particle (PM10) exposure.
Cell biology and toxicology 2008;24(3):243-52.
2008: Nicholas L Mills; J J Miller; A Anand; Simon D Robinson; G A Frazer; D Anderson; L Breen; I B Wilkinson; C M McEniery; Ken Donaldson; David E Newby; William MacNee
Increased arterial stiffness in patients with chronic obstructive pulmonary disease: a mechanism for increased cardiovascular risk.
Thorax 2008;63(4):306-11.
2008: Robert M Mroz; Roel P F Schins; H Li; Luis A Jimenez; Ellen M Drost; Adam Holownia; William MacNee; Ken Donaldson
Nanoparticle-driven DNA damage mimics irradiation-related carcinogenesis pathways.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2008;31(2):241-51.
2008: Ken Donaldson; Paul J A Borm; G Oberdorster; Kent E Pinkerton; Vicki Stone; C L Tran
Concordance between in vitro and in vivo dosimetry in the proinflammatory effects of low-toxicity, low-solubility particles: the key role of the proximal alveolar region.
Inhalation toxicology 2008;20(1):53-62.
2007: Ken Donaldson; Anthony Seaton
The Janus faces of nanoparticles.
Journal of nanoscience and nanotechnology 2007;7(12):4607-11.
2007: Robert M Mroz; Roel P F Schins; H Li; Ellen M Drost; William MacNee; Ken Donaldson
Nanoparticle carbon black driven DNA damage induces growth arrest and AP-1 and NFkappaB DNA binding in lung epithelial A549 cell line.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2007;58 Suppl 5(Pt 2):461-70.
2007: Robert M Mroz; Adam Holownia; Elzbieta Chyczewska; E M Drost; Jan J Braszko; J Noparlik; Ken Donaldson; William MacNee
Cytoplasm-nuclear trafficking of CREB and CREB phosphorylation at Ser133 during therapy of chronic obstructive pulmonary disease.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2007;58 Suppl 5(Pt 2):437-44.
2007: Nicholas L Mills; Håkan Törnqvist; Manuel C Gonzalez; Elen Vink; Simon D Robinson; Stefan Söderberg; Nicholas A Boon; Ken Donaldson; Thomas Sandström; Anders Blomberg; David E Newby
Ischemic and thrombotic effects of dilute diesel-exhaust inhalation in men with coronary heart disease.
The New England journal of medicine 2007;357(11):1075-82.
2007: Rodger Duffin; Nicholas L Mills; Ken Donaldson
Nanoparticles-a thoracic toxicology perspective.
Yonsei medical journal 2007;48(4):561-72.
2007: Håkan Törnqvist; Nicholas L Mills; Manuel Gonzalez; Mark R Miller; Simon D Robinson; Ian L Megson; William MacNee; Ken Donaldson; Stefan Söderberg; David E Newby; Thomas Sandström; Anders Blomberg
Persistent endothelial dysfunction in humans after diesel exhaust inhalation.
American journal of respiratory and critical care medicine 2007;176(4):395-400.
2007: Rodger Duffin; Lang Tran; David Brown; Vicki Stone; Ken Donaldson
Proinflammogenic effects of low-toxicity and metal nanoparticles in vivo and in vitro: highlighting the role of particle surface area and surface reactivity.
Inhalation toxicology 2007;19(10):849-56.
2007: Daniel S McQueen; Ken Donaldson; Susan M Bond; Jane D McNeilly; S Newman; Nicola J Barton; Rodger Duffin
Bilateral vagotomy or atropine pre-treatment reduces experimental diesel-soot induced lung inflammation.
Toxicology and applied pharmacology 2007;219(1):62-71.
2007: David M Brown; L Hutchison; Ken Donaldson; Simon MacKenzie; Dick Colin; Vicki Stone
The effect of oxidative stress on macrophages and lung epithelial cells: the role of phosphodiesterases 1 and 4.
Toxicology letters 2007;168(1):1-6.
2007: Nicholas L Mills; Håkan Törnqvist; Simon D Robinson; Manuel C Gonzalez; Stefan Söderberg; Thomas Sandström; Anders Blomberg; David E Newby; Ken Donaldson
Air pollution and atherothrombosis.
Inhalation toxicology 2007;19 Suppl 1():81-9.
2006: Andrew D Maynard; Robert J Aitken; Tilman Butz; Vicki L Colvin; Ken Donaldson; Günter Oberdörster; Martin A Philbert; John Ryan; Anthony Seaton; Vicki Stone; Sally S Tinkle; Lang Tran; Nigel J Walker; David B Warheit
Safe handling of nanotechnology.
Nature 2006;444(7117):267-9.
2006: Vicki Stone; Ken Donaldson
Nanotoxicology: signs of stress.
Nature nanotechnology 2006;1(1):23-4.
2006: Ken Donaldson
Resolving the nanoparticles paradox.
Nanomedicine (London, England) 2006;1(2):229-34.
2006: Patryk Szulakowski; Ann J L Crowther; Luis A Jiménez; Ken Donaldson; Ruth Mayer; Thomas B Leonard; William MacNee; Ellen M Drost
The effect of smoking on the transcriptional regulation of lung inflammation in patients with chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 2006;174(1):41-50.
2006: Ken Donaldson; Robert Aitken; Lang Tran; Vicki Stone; Rodger Duffin; Gavin Forrest; Andrew Alexander
Carbon nanotubes: a review of their properties in relation to pulmonary toxicology and workplace safety.
Toxicological sciences : an official journal of the Society of Toxicology 2006;92(1):5-22.
2006: Nicholas L Mills; Nadia Amin; Simon D Robinson; Atul Anand; John Davies; Dilip Patel; Jesus M de la Fuente; Flemming R Cassee; Nicholas A Boon; William MacNee; Alistair M Millar; Ken Donaldson; David E Newby
Do inhaled carbon nanoparticles translocate directly into the circulation in humans?
American journal of respiratory and critical care medicine 2006;173(4):426-31.
2006: Evelyn J Freney; Mathew R Heal; Robert J Donovan; Nicholas L Mills; Ken Donaldson; David E Newby; Paul H B Fokkens; Flemming R Cassee
A single-particle characterization of a mobile Versatile Aerosol Concentration Enrichment System for exposure studies.
Particle and fibre toxicology 2006;3():8.
2005: Nicholas L Mills; Håkan Törnqvist; Simon D Robinson; Manuel Gonzalez; Kareen Darnley; William MacNee; Nicholas A Boon; Ken Donaldson; Anders Blomberg; Thomas Sandstrom; David E Newby
Diesel exhaust inhalation causes vascular dysfunction and impaired endogenous fibrinolysis.
Circulation 2005;112(25):3930-6.
2005: Ken Donaldson; Lang Tran; Luis A Jimenez; Rodger Duffin; David E Newby; Nicholas L Mills; William MacNee; Vicki Stone
Combustion-derived nanoparticles: a review of their toxicology following inhalation exposure.
Particle and fibre toxicology 2005;2():10.
2005: Ken Donaldson; Nicholas L Mills; William MacNee; Simon Robinson; David Newby
Role of inflammation in cardiopulmonary health effects of PM.
Toxicology and applied pharmacology 2005;207(2 Suppl):483-8.
2005: Jane D McNeilly; L A Jiménez; M F Clay; William MacNee; A Howe; Mathew R Heal; Iain J Beverland; Ken Donaldson
Soluble transition metals in welding fumes cause inflammation via activation of NF-kappaB and AP-1.
Toxicology letters 2005;158(2):152-7.
2005: Anthony Seaton; John Cherrie; Martine Dennekamp; Ken Donaldson; J Fintan Hurley; C L Tran
The London Underground: dust and hazards to health.
Occupational and environmental medicine 2005;62(6):355-62.
2005: Peter G Barlow; Ken Donaldson; J MacCallum; Anna Clouter; Vicki Stone
Serum exposed to nanoparticle carbon black displays increased potential to induce macrophage migration.
Toxicology letters 2005;155(3):397-401.
2005: Peter S Gilmour; E Rona Morrison; Mark A Vickers; I Ford; C A Ludlam; Mike Greaves; Ken Donaldson; William MacNee
The procoagulant potential of environmental particles (PM10).
Occupational and environmental medicine 2005;62(3):164-71.
2005: Peter G Barlow; Anna Clouter-Baker; Ken Donaldson; Janis Maccallum; Vicki Stone
Carbon black nanoparticles induce type II epithelial cells to release chemotaxins for alveolar macrophages.
Particle and fibre toxicology 2005;2():11.
2005: Gary R Hutchison; David M Brown; Leon R Hibbs; Mathew R Heal; Ken Donaldson; Robert L Maynard; Michelle Monaghan; Andy Nicholl; Vicki Stone
The effect of refurbishing a UK steel plant on PM10 metal composition and ability to induce inflammation.
Respiratory research 2005;6():43.
2004: John A Marwick; Paul A Kirkham; Christopher S Stevenson; Henry Danahay; June Giddings; Keith Butler; Ken Donaldson; William MacNee; Irfan Rahman
Cigarette smoke alters chromatin remodeling and induces proinflammatory genes in rat lungs.
American journal of respiratory cell and molecular biology 2004;31(6):633-42.
2004: Geraint D Florida-James; Ken Donaldson; Vicki Stone
Athens 2004: the pollution climate and athletic performance.
Journal of sports sciences 2004;22(10):967-80; discussion 980.
2004: Ken Donaldson; C Lang Tran
An introduction to the short-term toxicology of respirable industrial fibres.
Mutation research 2004;553(1-2):5-9.
2004: Frank Antonicelli; David Brown; Maryline Parmentier; Ellen M Drost; Nik Hirani; Irfan Rahman; Ken Donaldson; William MacNee
Regulation of LPS-mediated inflammation in vivo and in vitro by the thiol antioxidant Nacystelyn.
American journal of physiology. Lung cellular and molecular physiology 2004;286(6):L1319-27.
2004: Louise Renwick; David Brown; Anna Clouter; Ken Donaldson
Increased inflammation and altered macrophage chemotactic responses caused by two ultrafine particle types.
Occupational and environmental medicine 2004;61(5):442-7.
2004: Vicki Stone; R Jones; K Rollo; Rodger Duffin; Ken Donaldson; David M Brown
Effect of coal mine dust and clay extracts on the biological activity of the quartz surface.
Toxicology letters 2004;149(1-3):255-9.
2004: Jane D McNeilly; Mathew R Heal; Iain J Beverland; Alan Howe; Mark D Gibson; Leon R Hibbs; William MacNee; Ken Donaldson
Soluble transition metals cause the pro-inflammatory effects of welding fumes in vitro.
Toxicology and applied pharmacology 2004;196(1):95-107.
2004: Peter S Gilmour; Axel Ziesenis; E Rona Morrison; Mark A Vickers; Ellen M Drost; Isobel Ford; Erwin Karg; Claudia Mossa; Andreas Schroeppel; George A Ferron; Joachim Heyder; Mike Greaves; William MacNee; Ken Donaldson
Pulmonary and systemic effects of short-term inhalation exposure to ultrafine carbon black particles.
Toxicology and applied pharmacology 2004;195(1):35-44.
2004: Roel P F Schins; Janet H Lightbody; Paul J A Borm; Tingming Shi; Ken Donaldson; Vicki Stone
Inflammatory effects of coarse and fine particulate matter in relation to chemical and biological constituents.
Toxicology and applied pharmacology 2004;195(1):1-11.
2004: David M Brown; Ken Donaldson; Paul J A Borm; Roel P F Schins; M Dehnhardt; Peter S Gilmour; Luis A Jimenez; Vicki Stone
Calcium and ROS-mediated activation of transcription factors and TNF-alpha cytokine gene expression in macrophages exposed to ultrafine particles.
American journal of physiology. Lung cellular and molecular physiology 2004;286(2):L344-53.
2004: David M Brown; Ken Donaldson; Vicki Stone
Effects of PM10 in human peripheral blood monocytes and J774 macrophages.
Respiratory research 2004;5():29.
2003: Julie A Wickenden; Murray C H Clarke; Adriano G Rossi; Irfan Rahman; Stephen P Faux; Ken Donaldson; William MacNee
Cigarette smoke prevents apoptosis through inhibition of caspase activation and induces necrosis.
American journal of respiratory cell and molecular biology 2003;29(5):562-70.
2003: Ken Donaldson; Vicki Stone; Paul J A Borm; Luis A Jimenez; Peter S Gilmour; Roel P F Schins; Ad M Knaapen; Irfan Rahman; Stephen P Faux; David M Brown; William MacNee
Oxidative stress and calcium signaling in the adverse effects of environmental particles (PM10).
Free radical biology & medicine 2003;34(11):1369-82.
2003: C L Tran; Alan D Jones; Brian Miller; Ken Donaldson
Modeling the retention and clearance of manmade vitreous fibers in the rat lung.
Inhalation toxicology 2003;15(6):553-87.
2003: Peter S Gilmour; Irfan Rahman; Ken Donaldson; William MacNee
Histone acetylation regulates epithelial IL-8 release mediated by oxidative stress from environmental particles.
American journal of physiology. Lung cellular and molecular physiology 2003;284(3):L533-40.
2003: Ken Donaldson; Vicki Stone
Current hypotheses on the mechanisms of toxicity of ultrafine particles.
Annali dell'Istituto superiore di sanità 2003;39(3):405-10.
2003: Dick Colin; David M Brown; Ken Donaldson; Vicki Stone
The role of free radicals in the toxic and inflammatory effects of four different ultrafine particle types.
Inhalation toxicology 2003;15(1):39-52.
2002: John A Marwick; Paul A Kirkham; Peter S Gilmour; Ken Donaldson; William MacNee; Irfan Rahman
Cigarette smoke-induced oxidative stress and TGF-beta1 increase p21waf1/cip1 expression in alveolar epithelial cells.
Annals of the New York Academy of Sciences 2002;973():278-83.
2002: Martin R Wilson; Janet H Lightbody; Ken Donaldson; Jill Sales; Vicki Stone
Interactions between ultrafine particles and transition metals in vivo and in vitro.
Toxicology and applied pharmacology 2002;184(3):172-9.
2002: Roel P F Schins; Rodger Duffin; Doris Höhr; Ad M Knaapen; Tingming Shi; Christel Weishaupt; Vicki Stone; Ken Donaldson; Paul J A Borm
Surface modification of quartz inhibits toxicity, particle uptake, and oxidative DNA damage in human lung epithelial cells.
Chemical research in toxicology 2002;15(9):1166-73.
2002: Hazel Jardine; William MacNee; Ken Donaldson; Irfan Rahman
Molecular mechanism of transforming growth factor (TGF)-beta1-induced glutathione depletion in alveolar epithelial cells. Involvement of AP-1/ARE and Fra-1.
The Journal of biological chemistry 2002;277(24):21158-66.
2002: Frank Antonicelli; Maryline Parmentier; Ellen M Drost; Nik Hirani; Irfan Rahman; Ken Donaldson; William MacNee
Nacystelyn inhibits oxidant-mediated interleukin-8 expression and NF-kappaB nuclear binding in alveolar epithelial cells.
Free radical biology & medicine 2002;32(6):492-502.
2002: Luis A Jiménez; Ellen M Drost; Peter S Gilmour; Irfan Rahman; Frank Antonicelli; H Ritchie; William MacNee; Ken Donaldson
PM(10)-exposed macrophages stimulate a proinflammatory response in lung epithelial cells via TNF-alpha.
American journal of physiology. Lung cellular and molecular physiology 2002;282(2):L237-48.
2002: Ken Donaldson; David Brown; Anna Clouter; Rodger Duffin; William MacNee; Louise Renwick; Lang Tran; Vicki Stone
The pulmonary toxicology of ultrafine particles.
Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine 2002;15(2):213-20.
2002: Ken Donaldson; C Lang Tran
Inflammation caused by particles and fibers.
Inhalation toxicology 2002;14(1):5-27.
2001: Rodger Duffin; Peter S Gilmour; Roel P F Schins; Anna Clouter; Keith Guy; David M Brown; William MacNee; Paul J A Borm; Ken Donaldson; Vicki Stone
Aluminium lactate treatment of DQ12 quartz inhibits its ability to cause inflammation, chemokine expression, and nuclear factor-kappaB activation.
Toxicology and applied pharmacology 2001;176(1):10-7.
2001: David M Brown; Martin R Wilson; William MacNee; Vicki Stone; Ken Donaldson
Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines.
Toxicology and applied pharmacology 2001;175(3):191-9.
2001: Irfan Rahman; B Mulier; Peter S Gilmour; Tammy M Watchorn; Ken Donaldson; P K Jeffery; William MacNee
Oxidant-mediated lung epithelial cell tolerance: the role of intracellular glutathione and nuclear factor-kappaB.
Biochemical pharmacology 2001;62(6):787-94.
2001: Anna Clouter; David Brown; Doris Höhr; Paul J A Borm; Ken Donaldson
Inflammatory effects of respirable quartz collected in workplaces versus standard DQ12 quartz: particle surface correlates.
Toxicological sciences : an official journal of the Society of Toxicology 2001;63(1):90-8.
2001: Peter S Gilmour; Irfan Rahman; S Hayashi; J C Hogg; Ken Donaldson; William MacNee
Adenoviral E1A primes alveolar epithelial cells to PM(10)-induced transcription of interleukin-8.
American journal of physiology. Lung cellular and molecular physiology 2001;281(3):L598-606.
2001: Ken Donaldson; V Stone; Anthony Seaton; William MacNee
Ambient particle inhalation and the cardiovascular system: potential mechanisms.
Environmental health perspectives 2001;109 Suppl 4():523-7.
2001: Martine Dennekamp; S Howarth; Dick Colin; John Cherrie; Ken Donaldson; Anthony Seaton
Ultrafine particles and nitrogen oxides generated by gas and electric cooking.
Occupational and environmental medicine 2001;58(8):511-6.
2001: Louise Renwick; Ken Donaldson; Anna Clouter
Impairment of alveolar macrophage phagocytosis by ultrafine particles.
Toxicology and applied pharmacology 2001;172(2):119-27.
2001: Ken Donaldson; Vicki Stone; Anna Clouter; Louise Renwick; William MacNee
Ultrafine particles.
Occupational and environmental medicine 2001;58(3):211-6, 199.
2001: Dick Colin; Martine Dennekamp; S Howarth; John Cherrie; Anthony Seaton; Ken Donaldson; Vicki Stone
Stimulation of IL-8 release from epithelial cells by gas cooker PM(10): a pilot study.
Occupational and environmental medicine 2001;58(3):208-10.
2001: Janet H Lightbody; LM Stevenson; Frank Jackson; Ken Donaldson; DG Jones
Comparative aspects of plasma antioxidant status in sheep and goats, and the influence of experimental abomasal nematode infection.
Journal of comparative pathology 2001;124(2-3):192-9.
2001: Ken Donaldson; Vicki Stone; Rodger Duffin; Anna Clouter; Roel P F Schins; Paul J A Borm
The quartz hazard: effects of surface and matrix on inflammogenic activity.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 2001;20 Suppl 1():109-18.
2000: CL Tran; D Buchanan; RT Cullen; A Searl; Alan D Jones; Ken Donaldson
Inhalation of poorly soluble particles. II. Influence Of particle surface area on inflammation and clearance.
Inhalation toxicology 2000;12(12):1113-26.
2000: RT Cullen; CL Tran; D Buchanan; J M G Davis; A Searl; Alan D Jones; Ken Donaldson
Inhalation of poorly soluble particles. I. Differences in inflammatory response and clearance during exposure.
Inhalation toxicology 2000;12(12):1089-111.
2000: Maryline Parmentier; Nik Hirani; Irfan Rahman; Ken Donaldson; William MacNee; Frank Antonicelli
Regulation of lipopolysaccharide-mediated interleukin-1beta release by N-acetylcysteine in THP-1 cells.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2000;16(5):933-9.
2000: M R Wilson; Vicki Stone; RT Cullen; A Searl; R L Maynard; Ken Donaldson
In vitro toxicology of respirable Montserrat volcanic ash.
Occupational and environmental medicine 2000;57(11):727-33.
2000: David M Brown; Vicki Stone; P Findlay; William MacNee; Ken Donaldson
Increased inflammation and intracellular calcium caused by ultrafine carbon black is independent of transition metals or other soluble components.
Occupational and environmental medicine 2000;57(10):685-91.
2000: Roel P F Schins; A McAlinden; William MacNee; Luis A Jimenez; James A Ross; Keith Guy; Stephen P Faux; Ken Donaldson
Persistent depletion of I kappa B alpha and interleukin-8 expression in human pulmonary epithelial cells exposed to quartz particles.
Toxicology and applied pharmacology 2000;167(2):107-17.
2000: Luis A Jiménez; J Thompson; D A Brown; Irfan Rahman; Frank Antonicelli; Rodger Duffin; Ellen M Drost; Ron Thomas Hay; Ken Donaldson; William MacNee
Activation of NF-kappaB by PM(10) occurs via an iron-mediated mechanism in the absence of IkappaB degradation.
Toxicology and applied pharmacology 2000;166(2):101-10.
2000: David M Brown; PH Beswick; KS Bell; Ken Donaldson
Depletion of glutathione and ascorbate in lung lining fluid by respirable fibres.
The Annals of occupational hygiene 2000;44(2):101-8.
2000: C E Fisher; A G Rossi; J Shaw; PH Beswick; Ken Donaldson
Release of TNFalpha in response to SiC fibres: differential effects in rodent and human primary macrophages, and in macrophage-like cell lines.
Toxicology in vitro : an international journal published in association with BIBRA 2000;14(1):25-31.
2000: Vicki Stone; M Tuinman; Joannis Vamvakopoulos; J Shaw; D Brown; S Petterson; Stephen P Faux; Paul J A Borm; William MacNee; F Michaelangeli; Ken Donaldson
Increased calcium influx in a monocytic cell line on exposure to ultrafine carbon black.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2000;15(2):297-303.
2000: Ken Donaldson; M I Gilmour; W MacNee
Asthma and PM10.
Respiratory research 2000;1(1):12-5.
2000: Ken Donaldson
Nonneoplastic lung responses induced in experimental animals by exposure to poorly soluble nonfibrous particles.
Inhalation toxicology 2000;12(1-2):121-39.
1999: CL Tran; Alan D Jones; RT Cullen; Ken Donaldson
Exploration of the mechanisms of retention and clearance of low-toxicity particles in the rat lung using a mathematical model.
Inhalation toxicology 1999;11(12):1077-108.
1999: CL Tran; Alan D Jones; RT Cullen; Ken Donaldson
Mathematical modeling of the retention and clearance of low-toxicity particles in the lung.
Inhalation toxicology 1999;11(12):1059-76.
1999: David M Brown; PH Beswick; Ken Donaldson
Induction of nuclear translocation of NF-kappaB in epithelial cells by respirable mineral fibres.
The Journal of pathology 1999;189(2):258-64.
1999: A Graham; J Higinbotham; D Allan; Ken Donaldson; PH Beswick
Chemical differences between long and short amosite asbestos: differences in oxidation state and coordination sites of iron, detected by infrared spectroscopy.
Occupational and environmental medicine 1999;56(9):606-11.
1999: X Y Li; David Brown; S Smith; W MacNee; Ken Donaldson
Short-term inflammatory responses following intratracheal instillation of fine and ultrafine carbon black in rats.
Inhalation toxicology 1999;11(8):709-31.
1999: Brian Miller; Alan D Jones; A Searl; D Buchanan; RT Cullen; Colin A Soutar; J M G Davis; Ken Donaldson
Influence of characteristics of inhaled fibres on development of tumours in the rat lung.
The Annals of occupational hygiene 1999;43(3):167-79.
1999: Brian Miller; A Searl; J M G Davis; Ken Donaldson; RT Cullen; R E Bolton; D Buchanan; Colin A Soutar
Influence of fibre length, dissolution and biopersistence on the production of mesothelioma in the rat peritoneal cavity.
The Annals of occupational hygiene 1999;43(3):155-66.
1998: Vicki Stone; J Shaw; David M Brown; William MacNee; Stephen P Faux; Ken Donaldson
The role of oxidative stress in the prolonged inhibitory effect of ultrafine carbon black on epithelial cell function.
Toxicology in vitro : an international journal published in association with BIBRA 1998;12(6):649-59.
1998: C E Fisher; David M Brown; J Shaw; PH Beswick; Ken Donaldson
Respirable fibres: surfactant coated fibres release more Fe3+ than native fibres at both pH 4.5 and 7.2.
The Annals of occupational hygiene 1998;42(5):337-45.
1998: Ken Donaldson; Paul J A Borm
The quartz hazard: a variable entity.
The Annals of occupational hygiene 1998;42(5):287-94.
1998: Irfan Rahman; A Bel; B Mulier; Ken Donaldson; William MacNee
Differential regulation of glutathione by oxidants and dexamethasone in alveolar epithelial cells.
The American journal of physiology 1998;275(1 Pt 1):L80-6.
1998: Janet H Lightbody; LM Stevenson; DG Jones; Ken Donaldson
Standardization of a spectrophotometric assay for plasma total antioxidant capacity.
Analytical biochemistry 1998;258(2):369-72.
1998: David M Brown; C Fisher; Ken Donaldson
Free radical activity of synthetic vitreous fibers: iron chelation inhibits hydroxyl radical generation by refractory ceramic fiber.
Journal of toxicology and environmental health. Part A 1998;53(7):545-61.
1998: X Y Li; Ken Donaldson; William MacNee
Lipopolysaccharide-induced alveolar epithelial permeability: the role of nitric oxide.
American journal of respiratory and critical care medicine 1998;157(4 Pt 1):1027-33.
1998: B Mulier; Irfan Rahman; Tammy M Watchorn; Ken Donaldson; William MacNee; P K Jeffery
Hydrogen peroxide-induced epithelial injury: the protective role of intracellular nonprotein thiols (NPSH).
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1998;11(2):384-91.
1997: Peter S Gilmour; David M Brown; PH Beswick; William MacNee; Irfan Rahman; Ken Donaldson
Free radical activity of industrial fibers: role of iron in oxidative stress and activation of transcription factors.
Environmental health perspectives 1997;105 Suppl 5():1313-7.
1997: Ken Donaldson; David M Brown; C Mitchell; M Dineva; PH Beswick; Peter S Gilmour; William MacNee
Free radical activity of PM10: iron-mediated generation of hydroxyl radicals.
Environmental health perspectives 1997;105 Suppl 5():1285-9.
1997: X Y Li; Peter S Gilmour; Ken Donaldson; William MacNee
In vivo and in vitro proinflammatory effects of particulate air pollution (PM10).
Environmental health perspectives 1997;105 Suppl 5():1279-83.
1997: RT Cullen; Brian Miller; J M G Davis; D M Brown; Ken Donaldson
Short-term inhalation and in vitro tests as predictors of fiber pathogenicity.
Environmental health perspectives 1997;105 Suppl 5():1235-40.
1997: C G Mitchell; J Slight; Ken Donaldson
Diffusible component from the spore surface of the fungus Aspergillus fumigatus which inhibits the macrophage oxidative burst is distinct from gliotoxin and other hyphal toxins.
Thorax 1997;52(9):796-801.
1997: David M Brown; N K Roberts; Ken Donaldson
Effect of coating with lung lining fluid on the ability of fibres to produce a respiratory burst in rat alveolar macrophages.
Toxicology in vitro : an international journal published in association with BIBRA 1997;12(1):15-24.
1996: X Y Li; P S Gilmour; Ken Donaldson; William MacNee
Free radical activity and pro-inflammatory effects of particulate air pollution (PM10) in vivo and in vitro.
Thorax 1996;51(12):1216-22.
1996: I M Bromley; Ken Donaldson
Binding of Aspergillus fumigatus spores to lung epithelial cells and basement membrane proteins: relevance to the asthmatic lung.
Thorax 1996;51(12):1203-9.
1996: Peter S Gilmour; David M Brown; T G Lindsay; PH Beswick; William MacNee; Ken Donaldson
Adverse health effects of PM10 particles: involvement of iron in generation of hydroxyl radical.
Occupational and environmental medicine 1996;53(12):817-22.
1996: C L Tran; Alan D Jones; Ken Donaldson
Evidence of overload, dissolution and breakage of MMVF10 fibres in the RCC chronic inhalation study.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1996;48(6):500-4.
1996: Ken Donaldson; PH Beswick; Peter S Gilmour
Free radical activity associated with the surface of particles: a unifying factor in determining biological activity?
Toxicology letters 1996;88(1-3):293-8.
1996: Irfan Rahman; D Morrison; Ken Donaldson; William MacNee
Systemic oxidative stress in asthma, COPD, and smokers.
American journal of respiratory and critical care medicine 1996;154(4 Pt 1):1055-60.
1996: W J Nicholson; J Slight; Ken Donaldson
Inhibition of the transcription factors NF-kappa B and AP-1 underlies loss of cytokine gene expression in rat alveolar macrophages treated with a diffusible product from the spores of Aspergillus fumigatus.
American journal of respiratory cell and molecular biology 1996;15(1):88-96.
1996: X Y Li; Irfan Rahman; Ken Donaldson; William MacNee
Mechanisms of cigarette smoke induced increased airspace permeability.
Thorax 1996;51(5):465-71.
1996: J Slight; W J Nicholson; C G Mitchell; N Pouilly; PH Beswick; A Seaton; Ken Donaldson
Inhibition of the alveolar macrophage oxidative burst by a diffusible component from the surface of the spores of the fungus Aspergillus fumigatus.
Thorax 1996;51(4):389-96.
1996: I M Hill; PH Beswick; Ken Donaldson
Enhancement of the macrophage oxidative burst by immunoglobulin coating of respirable fibers: fiber-specific differences between asbestos and man-made fibers.
Experimental lung research 1996;22(2):133-48.
1996: William MacNee; D Morrison; Irfan Rahman; X Y Li; Ken Donaldson
Cigarette smoke and ozone-induced epithelial perturbation in vivo and in vitro. The role of glutathione.
Chest 1996;109(3 Suppl):39S.
1996: Ken Donaldson
Short-term animal studies for detecting inflammation, fibrosis and pre-neoplastic changes induced by fibres.
IARC scientific publications 1996;(140):97-106.
1995: Peter S Gilmour; PH Beswick; David M Brown; Ken Donaldson
Detection of surface free radical activity of respirable industrial fibres using supercoiled phi X174 RF1 plasmid DNA.
Carcinogenesis 1995;16(12):2973-9.
1995: Ken Donaldson; N Golyasnya
Cytogenetic and pathogenic effects of long and short amosite asbestos.
The Journal of pathology 1995;177(3):303-7.
1995: D M Brown; E Drost; Ken Donaldson; William MacNee
Deformability and CD11/CD18 expression of sequestered neutrophils in normal and inflamed lungs.
American journal of respiratory cell and molecular biology 1995;13(5):531-9.
1995: Ken Donaldson; Peter S Gilmour; PH Beswick
Supercoiled plasmid DNA as a model target for assessing the generation of free radicals at the surface of fibres.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1995;47(4):235-7.
1995: Ken Donaldson; I M Hill; PH Beswick
Superoxide anion release by alveolar macrophages exposed to respirable industrial fibres: modifying effect of fibre opsonisation.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1995;47(4):229-31.
1995: Irfan Rahman; X Y Li; Ken Donaldson; David J Harrison; William MacNee
Glutathione homeostasis in alveolar epithelial cells in vitro and lung in vivo under oxidative stress.
The American journal of physiology 1995;269(3 Pt 1):L285-92.
1995: X Y Li; Ken Donaldson; D Brown; William MacNee
The role of tumor necrosis factor in increased airspace epithelial permeability in acute lung inflammation.
American journal of respiratory cell and molecular biology 1995;13(2):185-95.
1995: Irfan Rahman; X Y Li; Ken Donaldson; William MacNee
Cigarette smoke, glutathione metabolism and epithelial permeability in rat lungs.
Biochemical Society transactions 1995;23(2):235S.
1995: X Li; Ken Donaldson; William MacNee
Nitric oxide production, alveolar macrophages and type II alveolar epithelial cells in response to LPS in vivo and in vitro.
Biochemical Society transactions 1995;23(2):233S.
1995: Ken Donaldson; David M Brown; B G Miller; A R Brody
Bromo-deoxyuridine (BRDU) uptake in the lungs of rats inhaling amosite asbestos or vitreous fibres at equal airborne fibre concentrations.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1995;47(2-3):207-11.
1995: I M Hill; PH Beswick; Ken Donaldson
Differential release of superoxide anions by macrophages treated with long and short fibre amosite asbestos is a consequence of differential affinity for opsonin.
Occupational and environmental medicine 1995;52(2):92-6.
1994: Ken Donaldson; J Addison; Brian Miller; RT Cullen; J M G Davis
Use of the short-term inflammatory response in the mouse peritoneal cavity to assess the biological activity of leached vitreous fibers.
Environmental health perspectives 1994;102 Suppl 5():159-62.
1994: Ken Donaldson
Biological activity of respirable industrial fibres treated to mimic residence in the lung.
Toxicology letters 1994;72(1-3):299-305.
1994: X Y Li; D Lamb; Ken Donaldson
Mesothelial cell injury caused by pleural leukocytes from rats treated with intratracheal instillation of crocidolite asbestos or Corynebacterium parvum.
Environmental research 1994;64(2):181-91.
1994: S Lannan; Ken Donaldson; D Brown; W MacNee
Effect of cigarette smoke and its condensates on alveolar epithelial cell injury in vitro.
The American journal of physiology 1994;266(1 Pt 1):L92-100.
1993: X Y Li; D Lamb; Ken Donaldson
The production of TNF-alpha and IL-1-like activity by bronchoalveolar leucocytes after intratracheal instillation of crocidolite asbestos.
International journal of experimental pathology 1993;74(4):403-10.
1993: D M Brown; Ian Dransfield; G Z Wetherill; Ken Donaldson
LFA-1 and ICAM-1 in homotypic aggregation of rat alveolar macrophages: organic dust-mediated aggregation by a non-protein kinase C-dependent pathway.
American journal of respiratory cell and molecular biology 1993;9(2):205-12.
1993: Ken Donaldson; Brian Miller; E Sara; J Slight; R C Brown
Asbestos fibre length-dependent detachment injury to alveolar epithelial cells in vitro: role of a fibronectin-binding receptor.
International journal of experimental pathology 1993;74(3):243-50.
1993: Ken Donaldson; R C Brown; G M Brown
New perspectives on basic mechanisms in lung disease. 5. Respirable industrial fibres: mechanisms of pathogenicity.
Thorax 1993;48(4):390-5.
1993: X Y Li; G M Brown; D Lamb; Ken Donaldson
Reactive pleural inflammation caused by intratracheal instillation of killed microbes.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1993;6(1):27-34.
1993: X Y Li; D Lamb; Ken Donaldson
Production of interleukin 1 by rat pleural leucocytes in culture after intratracheal instillation of crocidolite asbestos.
British journal of industrial medicine 1993;50(1):90-4.
1992: Ken Donaldson; X Y Li; S Dogra; Brian Miller; G M Brown
Asbestos-stimulated tumour necrosis factor release from alveolar macrophages depends on fibre length and opsonization.
The Journal of pathology 1992;168(2):243-8.
1992: G M Brown; D M Brown; Ken Donaldson
Persistent inflammation and impaired chemotaxis of alveolar macrophages on cessation of dust exposure.
Environmental health perspectives 1992;97():91-4.
1992: Ken Donaldson; G M Brown; D M Brown; J Slight; X Y Li
Epithelial and extracellular matrix injury in quartz-inflamed lung: role of the alveolar macrophage.
Environmental health perspectives 1992;97():221-4.
1992: X Y Li; D Lamb; Ken Donaldson
Intratracheal injection of crocidolite asbestos depresses the secretion of tumor necrosis factor by pleural leukocytes in vitro.
Experimental lung research 1992;18(3):359-72.
1992: S Lannan; A McLean; E Drost; M Gillooly; Ken Donaldson; D Lamb; W MacNee
Changes in neutrophil morphology and morphometry following exposure to cigarette smoke.
International journal of experimental pathology 1992;73(2):183-91.
1992: D M Brown; G M Brown; W Macnee; Ken Donaldson
Activated human peripheral blood neutrophils produce epithelial injury and fibronectin breakdown in vitro.
Inflammation 1992;16(1):21-30.
1991: Ken Donaldson; G M Brown; D M Brown; J Slight; W M Maclaren; J M G Davis
Leukocyte-mediated epithelial injury in ozone-exposed rat lung.
Research report (Health Effects Institute) 1991;(44):1-27.
1991: William MacNee; M M Bridgeman; M Marsden; E Drost; S Lannan; C Selby; Ken Donaldson
The effects of N-acetylcysteine and glutathione on smoke-induced changes in lung phagocytes and epithelial cells.
The American journal of medicine 1991;91(3C):60S-66S.
1991: X Y Li; G M Brown; D Lamb; Ken Donaldson
Increased production of plasminogen activator inhibitor in vitro by pleural leukocytes from rats intratracheally instilled with crocidolite asbestos.
Environmental research 1991;55(2):135-44.
1991: E Drost; S Lannan; M M Bridgeman; D Brown; C Selby; Ken Donaldson; William MacNee
Lack of effect of N-acetylcysteine on the release of oxygen radicals from neutrophils and alveolar macrophages.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1991;4(6):723-9.
1991: Ken Donaldson; G M Brown; E Drost; C Selby; William MacNee
Does cigarette smoke enhance the proteolytic activity of neutrophils?
Annals of the New York Academy of Sciences 1991;624():325-7.
1991: G M Brown; E Drost; C Selby; Ken Donaldson; William MacNee
Neutrophil sequestration in rat lungs.
Annals of the New York Academy of Sciences 1991;624():316-7.
1990: Ken Donaldson; G M Brown; D M Brown; M D Robertson; J Slight; Hilary Cowie; Alan D Jones; R E Bolton; J M G Davis
Contrasting bronchoalveolar leukocyte responses in rats inhaling coal mine dust, quartz, or titanium dioxide: effects of coal rank, airborne mass concentration, and cessation of exposure.
Environmental research 1990;52(1):62-76.
1990: James H Vincent; Ken Donaldson
A dosimetric approach for relating the biological response of the lung to the accumulation of inhaled mineral dust.
British journal of industrial medicine 1990;47(5):302-7.
1990: Y Kusaka; R T Cullen; Ken Donaldson
Immunomodulation in mineral dust-exposed lungs: stimulatory effect and interleukin-1 release by neutrophils from quartz-elicited alveolitis.
Clinical and experimental immunology 1990;80(2):293-8.
1990: Ken Donaldson; G M Brown; D M Brown; J Slight; RT Cullen; R G Love; Colin A Soutar
Inflammation in the lungs of rats after deposition of dust collected from the air of wool mills: the role of epithelial injury and complement activation.
British journal of industrial medicine 1990;47(4):231-8.
1990: Ken Donaldson; G M Brown; D M Brown; J Slight; M D Robertson; J M G Davis
Impaired chemotactic responses of bronchoalveolar leukocytes in experimental pneumoconiosis.
The Journal of pathology 1990;160(1):63-9.
1990: X Y Li; G M Brown; D Lamb; Ken Donaldson
Secretion of plasminogen activator inhibitor by normal rat pleural leukocytes in culture.
Lung 1990;168(6):309-22.
1989: G M Brown; Ken Donaldson
Inflammatory responses in lungs of rats inhaling coalmine dust: enhanced proteolysis of fibronectin by bronchoalveolar leukocytes.
British journal of industrial medicine 1989;46(12):866-72.
1989: G M Brown; Ken Donaldson; D M Brown
Bronchoalveolar leukocyte response in experimental silicosis: modulation by a soluble aluminum compound.
Toxicology and applied pharmacology 1989;101(1):95-105.
1989: Ken Donaldson; J Slight; D M Brown
Effects of products from inflammatory pulmonary neutrophils on alveolar macrophage chemotaxis, spreading, and thymidine incorporation.
Inflammation 1989;13(4):443-53.
1989: Ken Donaldson; G M Brown
Phagocyte-derived oxidant and protease in mineral dust-related lung disease.
FEMS microbiology immunology 1989;1(5):307-8.
1989: Ken Donaldson; G M Brown; D M Brown; R E Bolton; J M G Davis
Inflammation generating potential of long and short fibre amosite asbestos samples.
British journal of industrial medicine 1989;46(4):271-6.
1988: Ken Donaldson; J Slight; R E Bolton
The effect of products from bronchoalveolar-derived neutrophils on oxidant production and phagocytic activity of alveolar macrophages.
Clinical and experimental immunology 1988;74(3):477-82.
1988: Ken Donaldson; G M Brown; R E Bolton; J M G Davis
Fibrinolysis by rat mesothelial cells in vitro: the effect of mineral dusts at non-toxic doses.
British journal of experimental pathology 1988;69(4):487-94.
1988: Ken Donaldson; R E Bolton; A Jones; G M Brown; M D Robertson; J Slight; Hilary Cowie; J M G Davis
Kinetics of the bronchoalveolar leucocyte response in rats during exposure to equal airborne mass concentrations of quartz, chrysotile asbestos, or titanium dioxide.
Thorax 1988;43(7):525-33.
1988: Ken Donaldson; J Slight; G M Brown; R E Bolton
The ability of inflammatory bronchoalveolar leucocyte populations elicited with microbes or mineral dust to injure alveolar epithelial cells and degrade extracellular matrix in vitro.
British journal of experimental pathology 1988;69(3):327-38.
1988: Ken Donaldson; J Slight; R E Bolton
Oxidant production by control and inflammatory bronchoalveolar leukocyte populations treated with mineral dusts in vitro.
Inflammation 1988;12(3):231-43.
1988: G M Brown; Ken Donaldson
Degradation of connective tissue components by lung derived leucocytes in vitro: role of proteases and oxidants.
Thorax 1988;43(2):132-9.
1987: Ken Donaldson; J Slight; R E Bolton
In vitro fibrinolytic activity and viability of rat alveolar macrophages treated with inflammation generating mineral dusts.
Agents and actions 1987;20(1-2):87-92.
1986: J M G Davis; J Addison; R E Bolton; Ken Donaldson; Alan D Jones; T Smith
The pathogenicity of long versus short fibre samples of amosite asbestos administered to rats by inhalation and intraperitoneal injection.
British journal of experimental pathology 1986;67(3):415-30.
1986: J M G Davis; J Addison; R E Bolton; Ken Donaldson; Alan D Jones
Inhalation and injection studies in rats using dust samples from chrysotile asbestos prepared by a wet dispersion process.
British journal of experimental pathology 1986;67(1):113-29.
1986: R E Bolton; J Addison; J M G Davis; Ken Donaldson; Alan D Jones; Brian Miller; A Wright
Effects of the inhalation of dusts from calcium silicate insulation materials in laboratory rats.
Environmental research 1986;39(1):26-43.
1985: Ken Donaldson; J Slight; D Hannant; R E Bolton
Increased release of hydrogen peroxide and superoxide anion from asbestos-primed macrophages. Effect of hydrogen peroxide on the functional activity of alpha 1-protease inhibitor.
Inflammation 1985;9(2):139-47.
1985: J M G Davis; J Addison; R E Bolton; Ken Donaldson; Alan D Jones; Brian Miller
Inhalation studies on the effects of tremolite and brucite dust in rats.
Carcinogenesis 1985;6(5):667-74.
1980: J M Davis; S T Beckett; R E Bolton; Ken Donaldson
The effects of intermittent high asbestos exposure (peak dose levels) on the lungs of rats.
British journal of experimental pathology 1980;61(3):272-80.
1980: I P Gormley; R E Bolton; G Brown; J M Davis; Ken Donaldson
Studies on the morphological patterns of asbestos induced mesotheliomas in vivo and in vitro.
Carcinogenesis 1980;1(3):219-31.
1980: J M Davis; S T Beckett; R E Bolton; Ken Donaldson
A comparison of the pathological effects in rats of the UICC reference samples of amosite and chrysotile with those of amosite and chrysotile collected from the factory environment.
IARC scientific publications 1980;(30):285-92.