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Lawrence Donehower

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Tajhal Dayaram; Lawrence A Donehower; Francene J Lemoine; Susan J Marriott
Activation of WIP1 phosphatase by HTLV-1 Tax mitigates the cellular response to DNA damage.
Lawrence A Donehower; Richard A Gibbs; Preethi H Gunaratne; Stanley R Hamilton; Donna M Muzny; Chris Sander; Nikolaus Schultz; Eve Shinbrot; Kyle Chang; Chad J Creighton; David Wheeler
MLH1-silenced and non-silenced subgroups of hypermutated colorectal carcinomas have distinct mutational landscapes.
Lawrence A Donehower
Rapamycin as longevity enhancer and cancer preventative agent in the context of p53 deficiency.

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2013: Tajhal Dayaram; Lawrence A Donehower; Francene J Lemoine; Susan J Marriott
Activation of WIP1 phosphatase by HTLV-1 Tax mitigates the cellular response to DNA damage.
PloS one 2013;8(2):e55989.
2013: Lawrence A Donehower; Richard A Gibbs; Preethi H Gunaratne; Stanley R Hamilton; Donna M Muzny; Chris Sander; Nikolaus Schultz; Eve Shinbrot; Kyle Chang; Chad J Creighton; David Wheeler
MLH1-silenced and non-silenced subgroups of hypermutated colorectal carcinomas have distinct mutational landscapes.
The Journal of pathology 2013;229(1):99-110.
2012: Lawrence A Donehower
Rapamycin as longevity enhancer and cancer preventative agent in the context of p53 deficiency.
Aging 2012;4(10):660-1.
2012: Neha Parikh; Ryan L Shuck; Alan Herron; Thuy-Ai Nguyen; Lawrence A Donehower
Mouse tissues that undergo neoplastic progression after K-Ras activation are distinguished by nuclear translocation of phospho-Erk1/2 and robust tumor suppressor responses.
Molecular cancer research : MCR 2012;10(6):845-55.
2012: Yolanda F Darlington; A Herron; Xiongbin Lu; S-H Moon; Thuy-Ai Nguyen; P Rao; C Zhu; Lawrence A Donehower
Absence of Wip1 partially rescues Atm deficiency phenotypes in mice.
Oncogene 2012;31(9):1155-65.
2011: Hugh S Gannon; Lawrence A Donehower; Stephen Lyle; Stephen N Jones
Mdm2-p53 signaling regulates epidermal stem cell senescence and premature aging phenotypes in mouse skin.
Developmental biology 2011;353(1):1-9.
2010: X Shang; Sanjeev A Vasudevan; Yang Yu; N Ge; A D Ludwig; C L Wesson; K Wang; Susan M Burlingame; Y-J Zhao; Pulivarthi H Rao; X Lu; Heidi V Russell; M Fatih Okcu; M John Hicks; Jason M Shohet; Lawrence A Donehower; Jed Nuchtern; Jun Yang
Dual-specificity phosphatase 26 is a novel p53 phosphatase and inhibits p53 tumor suppressor functions in human neuroblastoma.
Oncogene 2010;29(35):4938-46.
2010: Thuy-Ai Nguyen; Scott D Slattery; Sung-Hwan Moon; Yolanda F Darlington; Xiongbin Lu; Lawrence A Donehower
The oncogenic phosphatase WIP1 negatively regulates nucleotide excision repair.
DNA repair 2010;9(7):813-23.
2010: Hongbing Liu; Christine H Herrmann; Karen Chiang; Tzu-Ling Sung; Sung-Hwan Moon; Lawrence A Donehower; Andrew P Rice
55K isoform of CDK9 associates with Ku70 and is involved in DNA repair.
Biochemical and biophysical research communications 2010;397(2):245-50.
2010: Sung-Hwan Moon; Thuy-Ai Nguyen; Yolanda Darlington; Xiongbin Lu; Lawrence A Donehower
Dephosphorylation of γ-H2AX by WIP1: an important homeostatic regulatory event in DNA repair and cell cycle control.
Cell cycle (Georgetown, Tex.) 2010;9(11):2092-6.
2010: Sung-Hwan Moon; Lin Lin; Xinna Zhang; Thuy-Ai Nguyen; Yolanda Darlington; Alan S Waldman; Xiongbin Lu; Lawrence A Donehower
Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair.
The Journal of biological chemistry 2010;285(17):12935-47.
2010: Shinji Maegawa; George Hinkal; Hyun Soo Kim; Lanlan Shen; Li Zhang; Jiexin Zhang; Nianxiang Zhang; Shoudan Liang; Lawrence A Donehower; Jean-Pierre J Issa
Widespread and tissue specific age-related DNA methylation changes in mice.
Genome research 2010;20(3):332-40.
2009: Lawrence A Donehower
Using mice to examine p53 functions in cancer, aging, and longevity.
Cold Spring Harbor perspectives in biology 2009;1(6):a001081.
2009: Lawrence A Donehower; Guillermina Lozano
20 years studying p53 functions in genetically engineered mice.
Nature reviews. Cancer 2009;9(11):831-41.
2009: George W Hinkal; Catherine Gatza; Neha Parikh; Lawrence A Donehower
Altered senescence, apoptosis, and DNA damage response in a mutant p53 model of accelerated aging.
Mechanisms of ageing and development 2009;130(4):262-71.
2009: Ou Ma; Wei-Wen Cai; Lars Zender; Tajhal Dayaram; Jianhe Shen; Alan J Herron; Scott W Lowe; Tsz-Kwong Man; Ching C Lau; Lawrence A Donehower
MMP13, Birc2 (cIAP1), and Birc3 (cIAP2), amplified on chromosome 9, collaborate with p53 deficiency in mouse osteosarcoma progression.
Cancer research 2009;69(6):2559-67.
2009: Lawrence A Donehower
Longevity regulation in flies: a role for p53.
Aging 2009;1(1):6-8.
2009: George Hinkal; Neha Parikh; Lawrence A Donehower
Timed somatic deletion of p53 in mice reveals age-associated differences in tumor progression.
PloS one 2009;4(8):e6654.
2008: Xiongbin Lu; Thuy-Ai Nguyen; Sung-Hwan Moon; Yolanda Darlington; Matthias Sommer; Lawrence A Donehower
The type 2C phosphatase Wip1: an oncogenic regulator of tumor suppressor and DNA damage response pathways.
Cancer metastasis reviews 2008;27(2):123-35.
2008: George Hinkal; Lawrence A Donehower
How does suppression of IGF-1 signaling by DNA damage affect aging and longevity?
Mechanisms of ageing and development 2008;129(5):243-53.
2008: Robert Craig Castellino; Massimiliano De Bortoli; Xiongbin Lu; Sung-Hwan Moon; Thuy-Ai Nguyen; Mark A Shepard; Pulivarthi H Rao; Lawrence A Donehower; John Y H Kim
Medulloblastomas overexpress the p53-inactivating oncogene WIP1/PPM1D.
Journal of neuro-oncology 2008;86(3):245-56.
2008: Xiongbin Lu; Thuy-Ai Nguyen; X Zhang; Lawrence A Donehower
The Wip1 phosphatase and Mdm2: cracking the "Wip" on p53 stability.
Cell cycle (Georgetown, Tex.) 2008;7(2):164-8.
2008: Catherine Gatza; Melissa Dumble; Frances S Kittrell; David G Edwards; Robert K Dearth; Adrian V Lee; Jianming Xu; Daniel Medina; Lawrence A Donehower
Altered mammary gland development in the p53+/m mouse, a model of accelerated aging.
Developmental biology 2008;313(1):130-41.
2007: George Hinkal; Lawrence A Donehower
Decline and fall of the tumor suppressor.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(47):18347-8.
2007: Lynette Moore; Xiongbin Lu; Nader Ghebranious; Stuart Tyner; Lawrence A Donehower
Aging-associated truncated form of p53 interacts with wild-type p53 and alters p53 stability, localization, and activity.
Mechanisms of ageing and development 2007;128(11-12):717-30.
2007: Xiongbin Lu; Ou Ma; Thuy-Ai Nguyen; Stephen N Jones; Moshe Oren; Lawrence A Donehower
The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop.
Cancer cell 2007;12(4):342-54.
2007: Stuart M Chambers; Chad A Shaw; Catherine Gatza; C Joseph Fisk; Lawrence A Donehower; Margaret A Goodell
Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation.
PLoS biology 2007;5(8):e201.
2007: Melissa Dumble; Lynette Moore; Stuart M Chambers; Hartmut Geiger; Gary Van Zant; Margaret A Goodell; Lawrence A Donehower
The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging.
Blood 2007;109(4):1736-42.
2007: Catherine Gatza; Lynette Moore; Melissa Dumble; Lawrence A Donehower
Tumor suppressor dosage regulates stem cell dynamics during aging.
Cell cycle (Georgetown, Tex.) 2007;6(1):52-5.
2006: Bonnie Nannenga; Xiongbin Lu; Melissa Dumble; Marc van Maanen; Thuy-Ai Nguyen; Richard Sutton; T Rajendra Kumar; Lawrence A Donehower
Augmented cancer resistance and DNA damage response phenotypes in PPM1D null mice.
Molecular carcinogenesis 2006;45(8):594-604.
2006: Kristopher K Frese; Isabel J Latorre; Sang-Hyuk Chung; Georgina Caruana; Alan Bernstein; Stephen N Jones; Lawrence A Donehower; Monica J Justice; Craig C Garner; Ronald T Javier
Oncogenic function for the Dlg1 mammalian homolog of the Drosophila discs-large tumor suppressor.
The EMBO journal 2006;25(6):1406-17.
2006: David A Proia; Bonnie Nannenga; Lawrence A Donehower; Nancy L Weigel
Dual roles for the phosphatase PPM1D in regulating progesterone receptor function.
The Journal of biological chemistry 2006;281(11):7089-101.
2005: Lawrence A Donehower; John E French; Stephen D Hursting
The utility of genetically altered mouse models for cancer research.
Mutation research 2005;576(1-2):1-3.
2005: Xiongbin Lu; Thuy-Ai Nguyen; Lawrence A Donehower
Reversal of the ATM/ATR-mediated DNA damage response by the oncogenic phosphatase PPM1D.
Cell cycle (Georgetown, Tex.) 2005;4(8):1060-4.
2005: Debdutta Bandyopadhyay; Catherine Gatza; Lawrence A Donehower; Estela E Medrano
Analysis of cellular senescence in culture in vivo: the senescence-associated beta-galactosidase assay.
Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.] 2005;Chapter 18():Unit 18.9.
2005: Xiongbin Lu; Bonnie Nannenga; Lawrence A Donehower
PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints.
Genes & development 2005;19(10):1162-74.
2005: Lawrence A Donehower
p53: guardian AND suppressor of longevity?
Experimental gerontology 2005;40(1-2):7-9.
2004: Xiongbin Lu; Thuy-Ai Nguyen; Ettore Appella; Lawrence A Donehower
Homeostatic regulation of base excision repair by a p53-induced phosphatase: linking stress response pathways with DNA repair proteins.
Cell cycle (Georgetown, Tex.) 2004;3(11):1363-6.
2004: Stephen D Hursting; Jackie A Lavigne; David Berrigan; Lawrence A Donehower; Barbara J Davis; James M Phang; J Carl Barrett; Susan N Perkins
Diet-gene interactions in p53-deficient mice: insulin-like growth factor-1 as a mechanistic target.
The Journal of nutrition 2004;134(9):2482S-2486S.
2004: Xiongbin Lu; Dora Bocangel; Bonnie Nannenga; Hiroshi Yamaguchi; Ettore Appella; Lawrence A Donehower
The p53-induced oncogenic phosphatase PPM1D interacts with uracil DNA glycosylase and suppresses base excision repair.
Molecular cell 2004;15(4):621-34.
2004: Melissa Dumble; Catherine Gatza; Stuart Tyner; Sundaresan Venkatachalam; Lawrence A Donehower
Insights into aging obtained from p53 mutant mouse models.
Annals of the New York Academy of Sciences 2004;1019():171-7.
2004: Dmitry V Bulavin; Crissy Phillips; Bonnie Nannenga; Oleg Timofeev; Lawrence A Donehower; Carl W Anderson; Ettore Appella; Albert J Fornace
Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway.
Nature genetics 2004;36(4):343-50.
2003: Lynette Moore; Sundaresan Venkatachalam; Hannes Vogel; Julie C Watt; Chao-Ling Wu; Heather A Steinman; Stephen N Jones; Lawrence A Donehower
Cooperativity of p19ARF, Mdm2, and p53 in murine tumorigenesis.
Oncogene 2003;22(49):7831-7.
2003: Richard D Storer; John E French; Lawrence A Donehower; D Gulezian; K Mitsumori; Leslie Recio; R H Schiestl; Frank D Sistare; N Tamaoki; T Usui; H van Steeg
Transgenic tumor models for carcinogen identification: the heterozygous Trp53-deficient and RasH2 mouse lines.
Mutation research 2003;540(2):165-76.
2003: Marc van Maanen; Jennie K Tidwell; Lawrence A Donehower; Richard E Sutton
Development of an HIV-based cDNA expression cloning system.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;8(1):167-73.
2003: Xiongbin Lu; Guillermina Lozano; Lawrence A Donehower
Activities of wildtype and mutant p53 in suppression of homologous recombination as measured by a retroviral vector system.
Mutation research 2003;522(1-2):69-83.
2003: Melissa Dumble; Lawrence A Donehower; Xiongbin Lu
Generation and characterization of p53 mutant mice.
Methods in molecular biology (Clifton, N.J.) 2003;234():29-49.
2003: Stephen N Jones; Lawrence A Donehower
Functional analysis of tumor suppressor genes in mice.
Methods in molecular biology (Clifton, N.J.) 2003;223():283-314.
2002: Binhai Zheng; Hannes Vogel; Lawrence A Donehower; Allan Bradley
Visual genotyping of a coat color tagged p53 mutant mouse line.
Cancer biology & therapy 2002;1(4):433-5.
2002: Lawrence A Donehower
Does p53 affect organismal aging?
Journal of cellular physiology 2002;192(1):23-33.
2002: Jene Choi; Bonnie Nannenga; Oleg N Demidov; Dmitry V Bulavin; Austin J Cooney; CORY BRAYTON; Yongxin Zhang; Innocent N Mbawuike; Allan Bradley; Ettore Appella; Lawrence A Donehower
Mice deficient for the wild-type p53-induced phosphatase gene (Wip1) exhibit defects in reproductive organs, immune function, and cell cycle control.
Molecular and cellular biology 2002;22(4):1094-105.
2002: Stuart Tyner; Sundaresan Venkatachalam; Jene Choi; Stephen Jones; Nader Ghebranious; Herbert Igelmann; Xiongbin Lu; Gabrielle Soron; Benjamin Cooper; CORY BRAYTON; Timothy Thompson; Gerard Karsenty; Allan Bradley; Sang Hee Park; Lawrence A Donehower
p53 mutant mice that display early ageing-associated phenotypes.
Nature 2002;415(6867):45-53.
2002: Daniel Medina; Robert Ullrich; Raymond Meyn; Roger Wiseman; Lawrence A Donehower
Environmental carcinogens and p53 tumor-suppressor gene interactions in a transgenic mouse model for mammary carcinogenesis.
Environmental and molecular mutagenesis 2002;39(2-3):178-83.
2001: J French; Richard D Storer; Lawrence A Donehower
The nature of the heterozygous Trp53 knockout model for identification of mutagenic carcinogens.
Toxicologic pathology 2001;29 Suppl():24-9.
2001: Sundaresan Venkatachalam; Stuart Tyner; C R Pickering; Scott E Boley; Leslie Recio; John E French; Lawrence A Donehower
Is p53 haploinsufficient for tumor suppression? Implications for the p53+/- mouse model in carcinogenicity testing.
Toxicologic pathology 2001;29 Suppl():147-54.
2001: Stephen D Hursting; Susan N Perkins; Lawrence A Donehower; Barbara J Davis
Cancer prevention studies in p53-deficient mice.
Toxicologic pathology 2001;29(1):137-41.
2000: XS Cui; Lawrence A Donehower
Differential gene expression in mouse mammary adenocarcinomas in the presence and absence of wild type p53.
Oncogene 2000;19(52):5988-96.
2000: Xiao-Jing Wang; DA Greenhalgh; Lawrence A Donehower; Dennis R Roop
Cooperation between Ha-ras and fos or transforming growth factor alpha overcomes a paradoxic tumor-inhibitory effect of p53 loss in transgenic mouse epidermis.
Molecular carcinogenesis 2000;29(2):67-75.
2000: Q Liu; S Guntuku; XS Cui; Shuhei Matsuoka; David Cortez; Katsuyuki Tamai; G Luo; S Carattini-Rivera; Francesco DeMayo; Allan Bradley; Lawrence A Donehower; Stephen J Elledge
Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint.
Genes & development 2000;14(12):1448-59.
2000: Scott E Boley; E E Anderson; John E French; Lawrence A Donehower; D B Walker; Leslie Recio
Loss of p53 in benzene-induced thymic lymphomas in p53+/- mice: evidence of chromosomal recombination.
Cancer research 2000;60(11):2831-5.
1999: J M Jones; XS Cui; Daniel Medina; Lawrence A Donehower
Heterozygosity of p21WAF1/CIP1 enhances tumor cell proliferation and cyclin D1-associated kinase activity in a murine mammary cancer model.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1999;10(4):213-22.
1999: Stuart Tyner; Jene Choi; Rodolfo Laucirica; R J Ford; Lawrence A Donehower
Increased tumor cell proliferation in murine tumors with decreasing dosage of wild-type p53.
Molecular carcinogenesis 1999;24(3):197-208.
1998: Nader Ghebranious; Lawrence A Donehower
Mouse models in tumor suppression.
Oncogene 1998;17(25):3385-400.
1998: Stephen N Jones; A R Hancock; H Vogel; Lawrence A Donehower; A Bradley
Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(26):15608-12.
1998: Sundaresan Venkatachalam; Y P Shi; Stephen N Jones; Hannes Vogel; Allan Bradley; D Pinkel; Lawrence A Donehower
Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation.
The EMBO journal 1998;17(16):4657-67.
1998: Sundaresan Venkatachalam; Lawrence A Donehower
Murine tumor suppressor models.
Mutation research 1998;400(1-2):391-407.
1997: J M Jones; Laura D Attardi; L A Godley; Rodolfo Laucirica; Daniel Medina; Tyler Jacks; Harold Varmus; Lawrence A Donehower
Absence of p53 in a mouse mammary tumor model promotes tumor cell proliferation without affecting apoptosis.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997;8(8):829-38.
1996: Stephen N Jones; A T Sands; A R Hancock; H Vogel; Lawrence A Donehower; SP Linke; Geoffrey M Wahl; Allan Bradley
The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(24):14106-11.
1996: Stephen N Jones; MA Ansari-Lari; A R Hancock; W J Jones; Richard A Gibbs; Lawrence A Donehower; Allan Bradley
Genomic organization of the mouse double minute 2 gene.
Gene 1996;175(1-2):209-13.
1996: Dominique Broccoli; L A Godley; Lawrence A Donehower; Harold Varmus; Titia de Lange
Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation.
Molecular and cellular biology 1996;16(7):3765-72.
1996: MA Bogue; Chengming Zhu; Estuardo Aguilar-Cordova; Lawrence A Donehower; David B Roth
p53 is required for both radiation-induced differentiation and rescue of V(D)J rearrangement in scid mouse thymocytes.
Genes & development 1996;10(5):553-65.
1996: Lawrence A Donehower; L A Godley; C M Aldaz; R Pyle; Y P Shi; D Pinkel; J Gray; Allan Bradley; Daniel Medina; Harold Varmus
The role of p53 loss in genomic instability and tumor progression in a murine mammary cancer model.
Progress in clinical and biological research 1996;395():1-11.
1995: MA Ansari-Lari; Lawrence A Donehower; Richard A Gibbs
Analysis of human immunodeficiency virus type 1 integrase mutants.
Virology 1995;213(2):680.
1995: Stephen N Jones; A E Roe; Lawrence A Donehower; Allan Bradley
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53.
Nature 1995;378(6553):206-8.
1995: Lawrence A Donehower; M Harvey; H Vogel; M J McArthur; Charles Montgomery; S H Park; T Thompson; R J Ford; Allan Bradley
Effects of genetic background on tumorigenesis in p53-deficient mice.
Molecular carcinogenesis 1995;14(1):16-22.
1995: A T Sands; M B Suraokar; A Sanchez; J E Marth; Lawrence A Donehower; Allan Bradley
p53 deficiency does not affect the accumulation of point mutations in a transgene target.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(18):8517-21.
1995: A M Yahanda; Janet M Bruner; Lawrence A Donehower; R S Morrison
Astrocytes derived from p53-deficient mice provide a multistep in vitro model for development of malignant gliomas.
Molecular and cellular biology 1995;15(8):4249-59.
1995: MA Ansari-Lari; Lawrence A Donehower; Richard A Gibbs
Analysis of human immunodeficiency virus type 1 integrase mutants.
Virology 1995;211(1):332-5.
1995: Estuardo Aguilar-Cordova; J Chinen; Lawrence A Donehower; J W Harper; Andrew P Rice; Janet S Butel; John W Belmont
Inhibition of HIV-1 by a double transdominant fusion gene.
Gene therapy 1995;2(3):181-6.
1995: Lawrence A Donehower; L A Godley; C M Aldaz; R Pyle; Y P Shi; D Pinkel; J Gray; Allan Bradley; Daniel Medina; Harold Varmus
Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability.
Genes & development 1995;9(7):882-95.
1995: Timothy C Thompson; S H Park; Terry L Timme; Chengzhen Ren; James A Eastham; Lawrence A Donehower; Allan Bradley; Dov Kadmon; Guang Yang
Loss of p53 function leads to metastasis in ras+myc-initiated mouse prostate cancer.
Oncogene 1995;10(5):869-79.
1995: M Harvey; H Vogel; D Morris; Allan Bradley; A Bernstein; Lawrence A Donehower
A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53-deficient mice.
Nature genetics 1995;9(3):305-11.
1994: M C Marin; B Hsu; Raymond E Meyn; Lawrence A Donehower; Adel K El-Naggar; Timothy J McDonnell
Evidence that p53 and bcl-2 are regulators of a common cell death pathway important for in vivo lymphomagenesis.
Oncogene 1994;9(11):3107-12.
1994: A Sands; Lawrence A Donehower; Allan Bradley
Gene-targeting and the p53 tumor-suppressor gene.
Mutation research 1994;307(2):557-72.
1994: D Joseph Jerry; Janet S Butel; Lawrence A Donehower; E J Paulson; C Cochran; Roger W Wiseman; Daniel Medina
Infrequent p53 mutations in 7,12-dimethylbenz[a]anthracene-induced mammary tumors in BALB/c and p53 hemizygous mice.
Molecular carcinogenesis 1994;9(3):175-83.
1994: Estuardo Aguilar-Cordova; J Chinen; Lawrence A Donehower; Dorothy E Lewis; John W Belmont
A sensitive reporter cell line for HIV-1 tat activity, HIV-1 inhibitors, and T cell activation effects.
AIDS research and human retroviruses 1994;10(3):295-301.
1994: R S Morrison; F Yamaguchi; H Saya; Janet M Bruner; A M Yahanda; Lawrence A Donehower; M Berger
Basic fibroblast growth factor and fibroblast growth factor receptor I are implicated in the growth of human astrocytomas.
Journal of neuro-oncology 1994;18(3):207-16.
1993: M Harvey; M J McArthur; Charles Montgomery; Janet S Butel; Allan Bradley; Lawrence A Donehower
Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice.
Nature genetics 1993;5(3):225-9.
1993: M Harvey; A T Sands; Robert S Weiss; M E Hegi; Roger W Wiseman; P Pantazis; B C Giovanella; Michael A Tainsky; Allan Bradley; Lawrence A Donehower
In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice.
Oncogene 1993;8(9):2457-67.
1993: M Harvey; M J McArthur; Charles Montgomery; Allan Bradley; Lawrence A Donehower
Genetic background alters the spectrum of tumors that develop in p53-deficient mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1993;7(10):938-43.
1992: R J Ford; Lawrence A Donehower; R C Bohannon
Studies on a type D retrovirus isolated from an AIDS patient lymphoma.
AIDS research and human retroviruses 1992;8(5):742-51.
1992: Lawrence A Donehower; M Harvey; Betty L Slagle; M J McArthur; Charles Montgomery; Janet S Butel; Allan Bradley
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours.
Nature 1992;356(6366):215-21.
1991: R C Bohannon; Lawrence A Donehower; R J Ford
Isolation of a type D retrovirus from B-cell lymphomas of a patient with AIDS.
Journal of virology 1991;65(11):5663-72.
1990: Lawrence A Donehower; R C Bohannon; R J Ford; Richard A Gibbs
The use of primers from highly conserved pol regions to identify uncharacterized retroviruses by the polymerase chain reaction.
Journal of virological methods 1990;28(1):33-46.
1989: Lawrence A Donehower; Betty L Slagle; Margie Wilde; G Darlington; Janet S Butel
Identification of a conserved sequence in the non-coding regions of many human genes.
Nucleic acids research 1989;17(2):699-710.
1988: Y Z Zhou; Betty L Slagle; Lawrence A Donehower; P vanTuinen; David Ledbetter; Janet S Butel
Structural analysis of a hepatitis B virus genome integrated into chromosome 17p of a human hepatocellular carcinoma.
Journal of virology 1988;62(11):4224-31.
1988: Lawrence A Donehower
Analysis of mutant Moloney murine leukemia viruses containing linker insertion mutations in the 3' region of pol.
Journal of virology 1988;62(11):3958-64.