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Zigang Dong

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Jeong Ah Hwang; Mun Kyung Hwang; Yongwoo Jang; Geun Og Ji; Jong-Eun Kim; Eun Jung Lee; Ki Won Lee; Semi Lim; Mi Hyun Oh; Uhtaek Oh; Dong Joo Shin; Ann M Bode; Zigang Dong; Hyong Joo Lee
20-O-β-d-glucopyranosyl-20(S)-protopanaxadiol, a metabolite of ginseng, inhibits colon cancer growth by targeting TRPC channel-mediated calcium influx.
Mee-Hyun Lee; Sung-Young Lee; Si Jun Park; Young-Joon Surh; Hua Xie; Zunnan Huang; Dong Joon Kim; Jae Young Kim; Myoung Ok Kim; Sung-Hyun Kim; Joydeb Kumar Kundu; Ann M Bode; Zigang Dong
Direct Targeting of MEK1/2 and RSK2 by Silybin Induces Cell-Cycle Arrest and Inhibits Melanoma Cell Growth.
Dong Joon Kim; Mee-Hyun Lee; Sung-Young Lee; Yani Li; Do Young Lim; Kanamata Reddy; Hua Xie; Young Il Yeom; Ann M Bode; Zigang Dong
CInQ-03, a novel allosteric MEK inhibitor, suppresses cancer growth in vitro and in vivo.

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2013: Jeong Ah Hwang; Mun Kyung Hwang; Yongwoo Jang; Geun Og Ji; Jong-Eun Kim; Eun Jung Lee; Ki Won Lee; Semi Lim; Mi Hyun Oh; Uhtaek Oh; Dong Joo Shin; Ann M Bode; Zigang Dong; Hyong Joo Lee
20-O-β-d-glucopyranosyl-20(S)-protopanaxadiol, a metabolite of ginseng, inhibits colon cancer growth by targeting TRPC channel-mediated calcium influx.
The Journal of nutritional biochemistry 2013;24(6):1096-104.
2013: Mee-Hyun Lee; Sung-Young Lee; Si Jun Park; Young-Joon Surh; Hua Xie; Zunnan Huang; Dong Joon Kim; Jae Young Kim; Myoung Ok Kim; Sung-Hyun Kim; Joydeb Kumar Kundu; Ann M Bode; Zigang Dong
Direct Targeting of MEK1/2 and RSK2 by Silybin Induces Cell-Cycle Arrest and Inhibits Melanoma Cell Growth.
Cancer prevention research (Philadelphia, Pa.) 2013;6(5):455-65.
2013: Dong Joon Kim; Mee-Hyun Lee; Sung-Young Lee; Yani Li; Do Young Lim; Kanamata Reddy; Hua Xie; Young Il Yeom; Ann M Bode; Zigang Dong
CInQ-03, a novel allosteric MEK inhibitor, suppresses cancer growth in vitro and in vivo.
Carcinogenesis 2013;34(5):1134-43.
2013: Mee-Hyun Lee; Sung-Young Lee; Young-Joon Surh; Ann M Bode; Yong-Yeon Cho; Bu Young Choi; Zunnan Huang; Dong Joon Kim; Myoung Ok Kim; Joydeb Kumar Kundu; Zigang Dong
Tumor suppressor p16INK4a inhibits cancer cell growth by downregulating eEF1A2 through a direct interaction.
Journal of cell science 2013;126(Pt 8):1744-52.
2013: Sufang Liu; Min Tang; Yongguan Tao; Lifang Yang; Lin Chen; Zigang Dong; Hongde Li; Lili Li; Wei Li; Zijian Li; Haidan Liu; Ann M Bode; Ya Cao
(-)-Epigallocatechin-3-gallate inhibition of Epstein-Barr virus spontaneous lytic infection involves ERK1/2 and PI3-K/Akt signaling in EBV-positive cells.
Carcinogenesis 2013;34(3):627-37.
2013: Sanguine Byun; Hanyong Chen; Zigang Dong; Eunjung Lee; Ki Won Lee; Seung Joon Lee; Semi Lim; Jiman Park; Jae Gak Yu; Hyong Joo Lee
Src kinase is a direct target of apigenin against UVB-induced skin inflammation.
Carcinogenesis 2013;34(2):397-405.
2013: Jixia Li; Ronald A Lubet; Nicola Normanno; Feng Zhu; Amelia D'Alessio; Antonella De Luca; Zigang Dong; Marna E Ericson; Clinton Grubbs; Ann M Bode
Quercetin-3-methyl ether inhibits lapatinib-sensitive and -resistant breast cancer cell growth by inducing G(2)/M arrest and apoptosis.
Molecular carcinogenesis 2013;52(2):134-43.
2013: Sohee Baek; Ann M Bode; Sanguine Byun; Zigang Dong; Yong-Seok Heo; Tad A Holak; Robert Huber; Sung Keun Jung; Nam Joo Kang; Bo Yeon Kim; Hyong Joo Lee; Marcelino Arciniega; Martin Augustin; Grzegorz M Popowicz; Nu Ry Song; Ki Won Lee
Structural and functional analysis of the natural JNK1 inhibitor quercetagetin.
Journal of molecular biology 2013;425(2):411-23.
2013: Juan Xu; Lifang Yang; Juanfang Zhong; Ann M Bode; Xiyun Deng; Zigang Dong; Lili Li; Min Tang; Yongguang Tao; Lanbo Xiao; Ya Cao
Tyrosylprotein sulfotransferase-1 and tyrosine sulfation of chemokine receptor 4 are induced by Epstein-Barr virus encoded latent membrane protein 1 and associated with the metastatic potential of human nasopharyngeal carcinoma.
PloS one 2013;8(3):e56114.
2012: Xiang Li; Yan Li; Ronald A Lubet; Weiya Ma; Janos Nadas; Naomi Oi; Lei Wang; Hua Xie; Dong Hoon Yu; Feng Zhu; Tatyana A Zykova; Dong Joon Kim; Myoung Ok Kim; Mee-Hyun Lee; Haitao Li; Shengqing Li; Ann M Bode; Ziming Dong; Zigang Dong
Ceftriaxone, an FDA-approved cephalosporin antibiotic, suppresses lung cancer growth by targeting Aurora B.
Carcinogenesis 2012;33(12):2548-57.
2012: Luqing Zhao; Ann M Bode; Ya Cao; Zigang Dong
Regulatory mechanisms and clinical perspectives of miRNA in tumor radiosensitivity.
Carcinogenesis 2012;33(11):2220-7.
2012: Naomi Oi; Myoung Ok Kim; Ann M Bode; Hanyong Chen; Ronald A Lubet; Zigang Dong
Taxifolin suppresses UV-induced skin carcinogenesis by targeting EGFR and PI3K.
Cancer prevention research (Philadelphia, Pa.) 2012;5(9):1103-14.
2012: Hua Xie; Feng Zhu; Ann M Bode; Zunnan Huang; Sung Keun Jung; Soouk Kang; Dong Joon Kim; Mee-Hyun Lee; Haitao Li; Xiang Li; Do Young Lim; Ronald A Lubet; Weiya Ma; Kanamata Reddy; Lei Wang; Zigang Dong
Identification of mammalian target of rapamycin as a direct target of fenretinide both in vitro and in vivo.
Carcinogenesis 2012;33(9):1814-21.
2012: Zhiwei He; Wei-Ya Ma; Caiguo Ye; Ann Bode; Ping Cui; Zigang Dong
Analysis of the role of p38 MAP kinase in epidermal growth factor-induced JB6 Cl41 cell transformation by cDNA array.
Gene 2012;497(1):71-8.
2012: Lili Guo; Lili Li; Min Tang; Lanbo Xiao; Lifang Yang; Ann M Bode; Zigang Dong; Ya Cao
Epstein-Barr virus oncoprotein LMP1 mediates survivin upregulation by p53 contributing to G1/S cell cycle progression in nasopharyngeal carcinoma.
International journal of molecular medicine 2012;29(4):574-80.
2012: Myoung Ok Kim; Sung-Hyun Kim; Kun Yeong Lee; Janos Nadas; Ke Yao; Dong-Hoon Yu; Zunnan Huang; Chul-Ho Jeong; Young-Sam Keum; Dong Joon Kim; Ann M Bode; Yong-Yeon Cho; Zigang Dong
ERK1 and ERK2 regulate embryonic stem cell self-renewal through phosphorylation of Klf4.
Nature structural & molecular biology 2012;19(3):283-90.
2012: Jixia Li; Kangdong Liu; Madhusoodanan Mottamal; Carlos P Sosa; Keyuan Zhou; Feng Zhu; Ann M Bode; G Tim Bowden; Yong-Yeon Cho; Haitao Li; Zigang Dong
Quercetin-3-methyl ether suppresses proliferation of mouse epidermal JB6 P+ cells by targeting ERKs.
Carcinogenesis 2012;33(2):459-65.
2012: Hanyong Chen; Ann M Bode; Haitao Li; Ronald A Lubet; Margarita Malakhova; Janos Nadas; Naomi Oi; Ke Yao; Zigang Dong
Prediction of molecular targets of cancer preventing flavonoid compounds using computational methods.
PloS one 2012;7(5):e38261.
2012: Haidan Liu; Yongguang Tao; Hui Zheng; Ann M Bode; Zigang Dong; Zhi Duan; Duosha Hu; Ming Li; Ya Cao
EBV-encoded LMP1 upregulates Igκ 3'enhancer activity and Igκ expression in nasopharyngeal cancer cells by activating the Ets-1 through ERKs signaling.
PloS one 2012;7(3):e32624.
2011: Yan Li; Ronald A Lubet; Weiya Ma; Ann M Bode; Dong Joon Kim; Zigang Dong
Discovery of novel checkpoint kinase 1 inhibitors by virtual screening based on multiple crystal structures.
Journal of chemical information and modeling 2011;51(11):2904-14.
2011: Dong Joon Kim; Jong-Eun Kim; Myoung Ok Kim; Yan Li; Ronald A Lubet; Janos Nadas; Kanamata Reddy; Jung-Hyun Shim; Nu Ry Song; Ann M Bode; Andria Carper; Yong-Yeon Cho; Zigang Dong
(3-Chloroacetyl)-indole, a novel allosteric AKT inhibitor, suppresses colon cancer growth in vitro and in vivo.
Cancer prevention research (Philadelphia, Pa.) 2011;4(11):1842-51.
2011: Duosha Hu; Yiqun Jiang; Lili Li; Ming Li; Haidan Liu; Hui Zheng; Ann M Bode; Zigang Dong; Zhi Duan; Ya Cao
Heterogeneity of aberrant immunoglobulin expression in cancer cells.
Cellular & molecular immunology 2011;8(6):479-85.
2011: Faqing Tang; Xiaowei Tang; Yuan Wu; Feiyan Zou; Chaojun Duan; Damao Huang; Wenhua Mei; Zhengke Peng; Ya Cao; Yu Chen; Zigang Dong
N,N'-dinitrosopiperazine-mediated ezrin protein phosphorylation via activation of Rho kinase and protein kinase C is involved in metastasis of nasopharyngeal carcinoma 6-10B cells.
The Journal of biological chemistry 2011;286(42):36956-67.
2011: Myoung Ok Kim; Sung-Hyun Kim; Mee Hyun Lee; Naomi Oi; Dong Hoon Yu; Ann M Bode; Tim G Bowden; Eun Jin Cho; Yong-Yeon Cho; Dong Joon Kim; Zigang Dong
Embryonic stem-cell-preconditioned microenvironment induces loss of cancer cell properties in human melanoma cells.
Pigment cell & melanoma research 2011;24(5):922-31.
2011: Darya V Urusova; Tatyana A Zykova; Ann M Bode; Andria Carper; Sung Keun Jung; Dong Joon Kim; Jung-Hyun Shim; Zigang Dong
Epigallocatechin-gallate suppresses tumorigenesis by directly targeting Pin1.
Cancer prevention research (Philadelphia, Pa.) 2011;4(9):1366-77.
2011: Shengqing Li; Weiya Ma; Cong Peng; Feng Zhu; Tatyana Zykova; Ann M Bode; Andria Carper; Yong Yeon Cho; Myoung Ok Kim; Alyssa Langfald; Zigang Dong
T-LAK cell-originated protein kinase (TOPK) phosphorylation of MKP1 protein prevents solar ultraviolet light-induced inflammation through inhibition of the p38 protein signaling pathway.
The Journal of biological chemistry 2011;286(34):29601-9.
2011: Andy T Y Lau; Sung-Young Lee; Sheng-Qing Li; Yan-Ming Xu; Zhiguo Zhang; Duo Zheng; Feng Zhu; Ann M Bode; Yong-Yeon Cho; Hong-Gyum Kim; Zigang Dong
Phosphorylation of histone H2B serine 32 is linked to cell transformation.
The Journal of biological chemistry 2011;286(30):26628-37.
2011: Bin Kang; Mintie Pu; Bruce Stillman; Weihong Wen; Zigang Dong; Gang-Qing Hu; Keji Zhao; Zhiguo Zhang
Phosphorylation of H4 Ser 47 promotes HIRA-mediated nucleosome assembly.
Genes & development 2011;25(13):1359-64.
2011: Xiang Li; Kangdong Liu; Weiya Ma; Margarita Malakhova; Cong Peng; Weihong Wen; Feng Zhu; Ann M Bode; Yong Yeon Cho; Ziming Dong; Hong-Gyum Kim; Tingting Li; Zigang Dong
Phosphorylation of caspase-7 by p21-activated protein kinase (PAK) 2 inhibits chemotherapeutic drug-induced apoptosis of breast cancer cell lines.
The Journal of biological chemistry 2011;286(25):22291-9.
2011: Nam Joo Kang; Ki Won Lee; Bo Hyun Kim; Ann M Bode; Hyong Joo Lee; Yong-Seok Heo; Lisa Boardman; Paul Limburg; Hyong Joo Lee; Zigang Dong
Coffee phenolic phytochemicals suppress colon cancer metastasis by targeting MEK and TOPK.
Carcinogenesis 2011;32(6):921-8.
2011: Sally E Dickinson; Erik R Olson; Jack Zhang; Simon J Cooper; Tania Melton; P Jane Criswell; Ana Casanova; Zigang Dong; Chengcheng Hu; Kathylynn Saboda; Elizabeth T Jacobs; David S Alberts; G Tim Bowden
p38 MAP kinase plays a functional role in UVB-induced mouse skin carcinogenesis.
Molecular carcinogenesis 2011;50(6):469-78.
2011: Shengqing Li; Ann M Bode; Feng Zhu; Kangdong Liu; Jishuai Zhang; Myoung Ok Kim; Kanamata Reddy; Tatyana Zykova; Wei-Ya Ma; Andria L Carper; Alyssa K Langfald; Zigang Dong
TRPV1-antagonist AMG9810 promotes mouse skin tumorigenesis through EGFR/Akt signaling.
Carcinogenesis 2011;32(5):779-85.
2011: Tingting Li; Jishuai Zhang; Feng Zhu; Weihong Wen; Tatyana Zykova; Xiang Li; Kangdong Liu; Cong Peng; Weiya Ma; Guozheng Shi; Zigang Dong; Ann M Bode; Zigang Dong
P21-activated protein kinase (PAK2)-mediated c-Jun phosphorylation at 5 threonine sites promotes cell transformation.
Carcinogenesis 2011;32(5):659-66.
2011: Dong Eun Lee; Ki Won Lee; Sanguine Byun; Sung Keun Jung; Nury Song; Sung Hwan Lim; Yong-Seok Heo; Jong Eun Kim; Nam Joo Kang; Bo Yeon Kim; G Tim Bowden; Ann M Bode; Hyong Joo Lee; Zigang Dong
7,3',4'-Trihydroxyisoflavone, a metabolite of the soy isoflavone daidzein, suppresses ultraviolet B-induced skin cancer by targeting Cot and MKK4.
The Journal of biological chemistry 2011;286(16):14246-56.
2011: Ann M Bode; Zigang Dong
The two faces of capsaicin.
Cancer research 2011;71(8):2809-14.
2011: Jong-Eun Kim; Dong-Eun Lee; Ki Won Lee; Joe Eun Son; Sang Kwon Seo; Jixia Li; Sung Keun Jung; Yong-Seok Heo; Madhusoodanan Mottamal; Ann M Bode; Zigang Dong; Hyong Joo Lee
Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3-K.
Cancer prevention research (Philadelphia, Pa.) 2011;4(4):582-91.
2011: Dong Eun Lee; Ki Won Lee; Sung Keun Jung; Eun Jung Lee; Jung A Hwang; Tae-Gyu Lim; Bo Yeon Kim; Ann M Bode; Hyong Joo Lee; Zigang Dong
6,7,4'-trihydroxyisoflavone inhibits HCT-116 human colon cancer cell proliferation by targeting CDK1 and CDK2.
Carcinogenesis 2011;32(4):629-35.
2011: Cong Peng; Yong-Yeon Cho; Feng Zhu; Jishuai Zhang; Weihong Wen; Yanming Xu; Ke Yao; Wei-Ya Ma; Ann M Bode; Zigang Dong
Phosphorylation of caspase-8 (Thr-263) by ribosomal S6 kinase 2 (RSK2) mediates caspase-8 ubiquitination and stability.
The Journal of biological chemistry 2011;286(9):6946-54.
2011: Ki Won Lee; Ann M Bode; Zigang Dong
Molecular targets of phytochemicals for cancer prevention.
Nature reviews. Cancer 2011;11(3):211-8.
2011: Kangdong Liu; Yong-Yeon Cho; Ke Yao; Janos Nadas; Dong Joon Kim; Eun-Jin Cho; Mee-Hyun Lee; Angelo Pugliese; Jishuai Zhang; Ann M Bode; Zigang Dong; Zigang Dong
Eriodictyol inhibits RSK2-ATF1 signaling and suppresses EGF-induced neoplastic cell transformation.
The Journal of biological chemistry 2011;286(3):2057-66.
2011: Feng Zhu; Tatyana A Zykova; Cong Peng; Jishuai Zhang; Yong-Yeon Cho; Duo Zheng; Ke Yao; Wei-Ya Ma; Andy T Y Lau; Ann M Bode; Zigang Dong
Phosphorylation of H2AX at Ser139 and a new phosphorylation site Ser16 by RSK2 decreases H2AX ubiquitination and inhibits cell transformation.
Cancer research 2011;71(2):393-403.
2011: Sung-Young Lee; Jae-Bong Park; Mae Ja Park; Jaeho Yoon; Sang-Wook Cha; Zigang Dong; Yoo-Seok Hwang; Chul-Ho Jeong; Jong-Il Kim; SungChan Kim; Hyun-Shik Lee; Jae-Yong Lee; Jaebong Kim
The function of heterodimeric AP-1 comprised of c-Jun and c-Fos in activin mediated Spemann organizer gene expression.
PloS one 2011;6(7):e21796.
2010: Kyung Mi Lee; Ki Won Lee; Sung Keun Jung; Eun Jung Lee; Yong-Seok Heo; Ann M Bode; Ronald A Lubet; Hyong Joo Lee; Zigang Dong
Kaempferol inhibits UVB-induced COX-2 expression by suppressing Src kinase activity.
Biochemical pharmacology 2010;80(12):2042-9.
2010: Weihong Wen; Feng Zhu; Jishuai Zhang; Young-Sam Keum; Tatyana Zykova; Ke Yao; Cong Peng; Duo Zheng; Yong-Yeon Cho; Wei-ya Ma; Ann M Bode; Zigang Dong
MST1 promotes apoptosis through phosphorylation of histone H2AX.
The Journal of biological chemistry 2010;285(50):39108-16.
2010: Ann M Bode; Ya Cao; Zigang Dong
Update on Cancer Prevention Research in the United States and China: the 2009 China--U.S. Forum on Frontiers of Cancer Research.
Cancer prevention research (Philadelphia, Pa.) 2010;3(12):1630-7.
2010: Naomi Oi; Chul-Ho Jeong; Janos Nadas; Yong-Yeon Cho; Angelo Pugliese; Ann M Bode; Zigang Dong
Resveratrol, a red wine polyphenol, suppresses pancreatic cancer by inhibiting leukotriene A₄hydrolase.
Cancer research 2010;70(23):9755-64.
2010: Chul-Ho Jeong; Yong-Yeon Cho; Myoung-Ok Kim; Sung-Hyun Kim; Eun-Jin Cho; Sung-Young Lee; Young-Jin Jeon; Kun Yeong Lee; Ke Yao; Young-Sam Keum; Ann M Bode; Zigang Dong
Phosphorylation of Sox2 cooperates in reprogramming to pluripotent stem cells.
Stem cells (Dayton, Ohio) 2010;28(12):2141-50.
2010: Young-Joon Surh; Ann M Bode; Zigang Dong
Breaking the NF-κB and STAT3 alliance inhibits inflammation and pancreatic tumorigenesis.
Cancer prevention research (Philadelphia, Pa.) 2010;3(11):1379-81.
2010: Tatyana A Zykova; Feng Zhu; Tatyana I Vakorina; Jishuai Zhang; Lee Ann Higgins; Darya V Urusova; Ann M Bode; Zigang Dong
T-LAK cell-originated protein kinase (TOPK) phosphorylation of Prx1 at Ser-32 prevents UVB-induced apoptosis in RPMI7951 melanoma cells through the regulation of Prx1 peroxidase activity.
The Journal of biological chemistry 2010;285(38):29138-46.
2010: Sung-Young Lee; Andy T Y Lau; Chul-Ho Jeong; Jung-Hyun Shim; Hong-Gyum Kim; Jaebong Kim; Ann M Bode; Zigang Dong
Histone XH2AX is required for Xenopus anterior neural development: critical role of threonine 16 phosphorylation.
The Journal of biological chemistry 2010;285(38):29525-34.
2010: Young Jin Jeon; Kun Yeong Lee; Yong-Yeon Cho; Angelo Pugliese; Hong-Gyum Kim; Chul-Ho Jeong; Ann M Bode; Zigang Dong
Role of NEK6 in tumor promoter-induced transformation in JB6 C141 mouse skin epidermal cells.
The Journal of biological chemistry 2010;285(36):28126-33.
2010: Mun Kyung Hwang; Ann M Bode; Sanguine Byun; Nu Ry Song; Hyong Joo Lee; Ki Won Lee; Zigang Dong
Cocarcinogenic effect of capsaicin involves activation of EGFR signaling but not TRPV1.
Cancer research 2010;70(17):6859-69.
2010: Cong Peng; Yong-Yeon Cho; Feng Zhu; Yan-Ming Xu; Weihong Wen; Wei-Ya Ma; Ann M Bode; Zigang Dong
RSK2 mediates NF-{kappa}B activity through the phosphorylation of IkappaBalpha in the TNF-R1 pathway.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(9):3490-9.
2010: Dong Eun Lee; Ki Won Lee; Nu Ry Song; Sang Kwon Seo; Yong-Seok Heo; Nam Joo Kang; Ann M Bode; Hyong Joo Lee; Zigang Dong
7,3',4'-Trihydroxyisoflavone inhibits epidermal growth factor-induced proliferation and transformation of JB6 P+ mouse epidermal cells by suppressing cyclin-dependent kinases and phosphatidylinositol 3-kinase.
The Journal of biological chemistry 2010;285(28):21458-66.
2010: Erik R Olson; Tania Melton; Sally E Dickinson; Zigang Dong; David S Alberts; G Tim Bowden
Quercetin potentiates UVB-Induced c-Fos expression: implications for its use as a chemopreventive agent.
Cancer prevention research (Philadelphia, Pa.) 2010;3(7):876-84.
2010: Margarita Malakhova; Igor D'Angelo; Hong-Gyum Kim; Igor Kurinov; Ann M Bode; Zigang Dong
The crystal structure of the active form of the C-terminal kinase domain of mitogen- and stress-activated protein kinase 1.
Journal of molecular biology 2010;399(1):41-52.
2010: Sung Keun Jung; Ki Won Lee; Ho Young Kim; Mi Hyun Oh; Sanguine Byun; Sung Hwan Lim; Yong-Seok Heo; Nam Joo Kang; Ann M Bode; Zigang Dong; Hyong Joo Lee
Myricetin suppresses UVB-induced wrinkle formation and MMP-9 expression by inhibiting Raf.
Biochemical pharmacology 2010;79(10):1455-61.
2010: Jung-Hyun Shim; Zheng-Yuan Su; Jung-Il Chae; Dong Joon Kim; Feng Zhu; Wei-Ya Ma; Ann M Bode; Chung S Yang; Zigang Dong
Epigallocatechin gallate suppresses lung cancer cell growth through Ras-GTPase-activating protein SH3 domain-binding protein 1.
Cancer prevention research (Philadelphia, Pa.) 2010;3(5):670-9.
2010: Sung Keun Jung; Ki Won Lee; Sanguine Byun; Eun Jung Lee; Jong-Eun Kim; Ann M Bode; Zigang Dong; Hyong Joo Lee
Myricetin inhibits UVB-induced angiogenesis by regulating PI-3 kinase in vivo.
Carcinogenesis 2010;31(5):911-7.
2010: Yan-Ming Xu; Feng Zhu; Yong-Yeon Cho; Andria Carper; Cong Peng; Duo Zheng; Ke Yao; Andy T Y Lau; Tatyana A Zykova; Hong-Gyum Kim; Ann M Bode; Zigang Dong
Extracellular signal-regulated kinase 8-mediated c-Jun phosphorylation increases tumorigenesis of human colon cancer.
Cancer research 2010;70(8):3218-27.
2010: Kyung Mi Lee; Ki Won Lee; Sanguine Byun; Sung Keun Jung; Sang Kwon Seo; Yong-Seok Heo; Ann M Bode; Hyong Joo Lee; Zigang Dong
5-deoxykaempferol plays a potential therapeutic role by targeting multiple signaling pathways in skin cancer.
Cancer prevention research (Philadelphia, Pa.) 2010;3(4):454-65.
2010: Sergey Fedorov; Sergey Dyshlovoy; Margarita M Monastyrnaya; Larisa Shubina; Elena Leychenko; Emma P Kozlovskaya; Jun-O Jin; Jong-Young Kwak; Ann M Bode; Zigang Dong; Valentin A Stonik
The anticancer effects of actinoporin RTX-A from the sea anemone Heteractis crispa (=Radianthus macrodactylus).
Toxicon : official journal of the International Society on Toxinology 2010;55(4):811-7.
2010: Sanguine Byun; Ki Won Lee; Sung Keun Jung; Eun Jung Lee; Mun Kyung Hwang; Sung Hwan Lim; Ann M Bode; Hyong Joo Lee; Zigang Dong
Luteolin inhibits protein kinase C(epsilon) and c-Src activities and UVB-induced skin cancer.
Cancer research 2010;70(6):2415-23.
2010: Steven P Stratton; David S Alberts; Janine G Einspahr; Paul M Sagerman; James Warneke; Clara Curiel-Lewandrowski; Paul B Myrdal; Kelly L Karlage; Brian J Nickoloff; Chris Brooks; Kathylynn Saboda; Michael Yozwiak; Mary F Krutzsch; Chengcheng Hu; Maria Lluria-Prevatt; Zigang Dong; George Bowden; Peter H Bartels
A phase 2a study of topical perillyl alcohol cream for chemoprevention of skin cancer.
Cancer prevention research (Philadelphia, Pa.) 2010;3(2):160-9.
2010: Hyeok-Ran Kwon; Ki Won Lee; Zigang Dong; Kyung-Bok Lee; Sang-Muk Oh
Requirement of T-lymphokine-activated killer cell-originated protein kinase for TRAIL resistance of human HeLa cervical cancer cells.
Biochemical and biophysical research communications 2010;391(1):830-4.
2009: Jung Yeon Kwon; Ki Won Lee; Jong-Eun Kim; Sung Keun Jung; Nam Joo Kang; Mun Kyung Hwang; Yong-Seok Heo; Ann M Bode; Zigang Dong; Hyong Joo Lee
Delphinidin suppresses ultraviolet B-induced cyclooxygenases-2 expression through inhibition of MAPKK4 and PI-3 kinase.
Carcinogenesis 2009;30(11):1932-40.
2009: Kyung Mi Lee; Ki Won Lee; Ann M Bode; Hyong Joo Lee; Zigang Dong
Tpl2 is a key mediator of arsenite-induced signal transduction.
Cancer research 2009;69(20):8043-9.
2009: Ke Yao; Yong-Yeon Cho; Ann M Bode; Anuradha Vummenthala; Jewn Giew Park; Kangdong Liu; Yuan-Ping Pang; Zigang Dong
A selective small-molecule inhibitor of c-Jun N-terminal kinase 1.
FEBS letters 2009;583(13):2208-12.
2009: Ann M Bode; Zigang Dong
Cancer prevention research - then and now.
Nature reviews. Cancer 2009;9(7):508-16.
2009: Chul-Ho Jeong; Ann M Bode; Angelo Pugliese; Yong-Yeon Cho; Hong-Gyum Kim; Jung-Hyun Shim; Young-Jin Jeon; Honglin Li; Hualiang Jiang; Zigang Dong
[6]-Gingerol suppresses colon cancer growth by targeting leukotriene A4 hydrolase.
Cancer research 2009;69(13):5584-91.
2009: Ann M Bode; Zigang Dong
Epigallocatechin 3-gallate and green tea catechins: United they work, divided they fail.
Cancer prevention research (Philadelphia, Pa.) 2009;2(6):514-7.
2009: Yong-Yeon Cho; Ke Yao; Angelo Pugliese; Margarita L Malakhova; Ann M Bode; Zigang Dong
A regulatory mechanism for RSK2 NH(2)-terminal kinase activity.
Cancer research 2009;69(10):4398-406.
2009: Hong Seok Choi; Ann M Bode; Jung-Hyun Shim; Sung-Young Lee; Zigang Dong
c-Jun N-terminal kinase 1 phosphorylates Myt1 to prevent UVA-induced skin cancer.
Molecular and cellular biology 2009;29(8):2168-80.
2009: Na Yeon Lee; Hoo-Kyun Choi; Jung-Hyun Shim; Keon Wook Kang; Zigang Dong; Hong Seok Choi
The prolyl isomerase Pin1 interacts with a ribosomal protein S6 kinase to enhance insulin-induced AP-1 activity and cellular transformation.
Carcinogenesis 2009;30(4):671-81.
2009: Ann M Bode; Zigang Dong
Signal transduction molecules as targets for cancer prevention.
Science signaling 2009;2(59):mr2.
2009: Ann M Bode; Yong-Yeon Cho; Duo Zheng; Feng Zhu; Marna E Ericson; Wei-Ya Ma; Ke Yao; Zigang Dong
Transient receptor potential type vanilloid 1 suppresses skin carcinogenesis.
Cancer research 2009;69(3):905-13.
2009: Nam Joo Kang; Ki Won Lee; Bong Jik Shin; Sung Keun Jung; Mun Kyung Hwang; Ann M Bode; Yong-Seok Heo; Hyong Joo Lee; Zigang Dong
Caffeic acid, a phenolic phytochemical in coffee, directly inhibits Fyn kinase activity and UVB-induced COX-2 expression.
Carcinogenesis 2009;30(2):321-30.
2009: Margarita Malakhova; Igor Kurinov; Kangdong Liu; Duo Zheng; Igor D'Angelo; Jung-Hyun Shim; Valerie Steinman; Ann M Bode; Zigang Dong
Structural diversity of the active N-terminal kinase domain of p90 ribosomal S6 kinase 2.
PloS one 2009;4(11):e8044.
2009: Yong-Yeon Cho; Faqing Tang; Ke Yao; Chengrong Lu; Feng Zhu; Duo Zheng; Angelo Pugliese; Ann M Bode; Zigang Dong
Cyclin-dependent kinase-3-mediated c-Jun phosphorylation at Ser63 and Ser73 enhances cell transformation.
Cancer research 2009;69(1):272-81.
2008: Nam Joo Kang; Ki Won Lee; Jung Yeon Kwon; Mun Kyung Hwang; Evgeny Rogozin; Yong-Seok Heo; Ann M Bode; Hyong Joo Lee; Zigang Dong
Delphinidin attenuates neoplastic transformation in JB6 Cl41 mouse epidermal cells by blocking Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling.
Cancer prevention research (Philadelphia, Pa.) 2008;1(7):522-31.
2008: Ki Won Lee; Nam Joo Kang; Evgeny Rogozin; Sang-Muk Oh; Yong Seok Heo; Angelo Pugliese; Ann M Bode; Hyong Joo Lee; Zigang Dong
The resveratrol analogue 3,5,3',4',5'-pentahydroxy-trans-stilbene inhibits cell transformation via MEK.
International journal of cancer. Journal international du cancer 2008;123(11):2487-96.
2008: Wei Luo; Guangrong Yan; Lili Li; Zhenlian Wang; Haidan Liu; Shanghui Zhou; Sufang Liu; Min Tang; Wei Yi; Zigang Dong; Ya Cao
Epstein-Barr virus latent membrane protein 1 mediates serine 25 phosphorylation and nuclear entry of annexin A2 via PI-PLC-PKCalpha/PKCbeta pathway.
Molecular carcinogenesis 2008;47(12):934-46.
2008: Jung-Hyun Shim; Hong Seok Choi; Angelo Pugliese; Sung-Young Lee; Jung-Il Chae; Bu Young Choi; Ann M Bode; Zigang Dong
(-)-Epigallocatechin gallate regulates CD3-mediated T cell receptor signaling in leukemia through the inhibition of ZAP-70 kinase.
The Journal of biological chemistry 2008;283(42):28370-9.
2008: Erik R Olson; Tania Melton; Zigang Dong; George Bowden
Stabilization of quercetin paradoxically reduces its proapoptotic effect on UVB-irradiated human keratinocytes.
Cancer prevention research (Philadelphia, Pa.) 2008;1(5):362-8.
2008: Tatyana A Zykova; Feng Zhu; Xiuhong Zhai; Wei-Ya Ma; Svetlana Ermakova; Ki Won Lee; Ann M Bode; Zigang Dong
Resveratrol directly targets COX-2 to inhibit carcinogenesis.
Molecular carcinogenesis 2008;47(10):797-805.
2008: Duo Zheng; Yong-Yeon Cho; Andy T Y Lau; Jishuai Zhang; Wei-Ya Ma; Ann M Bode; Zigang Dong
Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation.
Cancer research 2008;68(18):7650-60.
2008: Nam Joo Kang; Ki Won Lee; Dong Eun Lee; Evgeny Rogozin; Ann M Bode; Hyong Joo Lee; Zigang Dong
Cocoa procyanidins suppress transformation by inhibiting mitogen-activated protein kinase kinase.
The Journal of biological chemistry 2008;283(30):20664-73.
2008: Sung Keun Jung; Ki Won Lee; Sanguine Byun; Nam Joo Kang; Sung Hwan Lim; Yong-Seok Heo; Ann M Bode; George Bowden; Hyong Joo Lee; Zigang Dong
Myricetin suppresses UVB-induced skin cancer by targeting Fyn.
Cancer research 2008;68(14):6021-9.
2008: Jichao Qin; He-Ge Chen; Qin Yan; Mi Deng; Jinping Liu; Stephan Doerge; Weiya Ma; Zigang Dong; Wan-Cheng David Li
Protein phosphatase-2A is a target of epigallocatechin-3-gallate and modulates p53-Bak apoptotic pathway.
Cancer research 2008;68(11):4150-62.
2008: Evgeny Rogozin; Ki Won Lee; Nam Joo Kang; Haoyu Yu; Masaaki Nomura; Ken-Ichi Miyamoto; Allan H Conney; Ann M Bode; Zigang Dong
Inhibitory effects of caffeine analogues on neoplastic transformation: structure-activity relationship.
Carcinogenesis 2008;29(6):1228-34.
2008: Duo Zheng; Ann M Bode; Qing Zhao; Yong-Yeon Cho; Feng Zhu; Wei-Ya Ma; Zigang Dong
The cannabinoid receptors are required for ultraviolet-induced inflammation and skin cancer development.
Cancer research 2008;68(10):3992-8.
2008: Na Yeon Lee; Svetlana P Ermakova; Tatyana N Zvyagintseva; Keon Wook Kang; Zigang Dong; Hong Seok Choi
Inhibitory effects of fucoidan on activation of epidermal growth factor receptor and cell transformation in JB6 Cl41 cells.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008;46(5):1793-800.
2008: Hong-Gyum Kim; Ki Won Lee; Yong-Yeon Cho; Nam Joo Kang; Sang-Muk Oh; Ann M Bode; Zigang Dong
Mitogen- and stress-activated kinase 1-mediated histone H3 phosphorylation is crucial for cell transformation.
Cancer research 2008;68(7):2538-47.
2008: Sergey N Fedorov; Oleg S Radchenko; Larisa K Shubina; Nadezda N Balaneva; Irina G Agafonova; Ann M Bode; Jun-O Jin; Jong-Young Kwak; Zigang Dong; Valentin A Stonik
Anticancer activity of 3-demethylubiquinone Q2. In vivo experiments and probable mechanism of action.
Anticancer research 2008;28(2A):927-32.
2008: Alexandra S Silchenko; Sergey A Avilov; Vladimir I Kalinin; Anatoly I Kalinovsky; Pavel S Dmitrenok; Sergey N Fedorov; Vadim G Stepanov; Zigang Dong; Valentin A Stonik
Constituents of the sea cucumber Cucumaria okhotensis. Structures of okhotosides B1-B3 and cytotoxic activities of some glycosides from this species.
Journal of natural products 2008;71(3):351-6.
2008: Janine G Einspahr; George Bowden; David S Alberts; Naja McKenzie; Kathylynn Saboda; James Warneke; Stuart Salasche; James Ranger-Moore; Clara Curiel-Lewandrowski; Raymond B Nagle; Brian J Nickoloff; Chris Brooks; Zigang Dong; Steven P Stratton
Cross-validation of murine UV signal transduction pathways in human skin.
Photochemistry and photobiology 2008;84(2):463-76.
2008: Zhiwei He; Faqing Tang; Svetlana Ermakova; Ming Li; Qing Zhao; Yong-Yeon Cho; Wei-Ya Ma; Hong-Seok Choi; Ann M Bode; Chung S Yang; Zigang Dong
Fyn is a novel target of (-)-epigallocatechin gallate in the inhibition of JB6 Cl41 cell transformation.
Molecular carcinogenesis 2008;47(3):172-83.
2008: Ki Won Lee; Nam Joo Kang; Yong-Seok Heo; Evgeny Rogozin; Angelo Pugliese; Mun Kyung Hwang; George Bowden; Ann M Bode; Hyong Joo Lee; Zigang Dong
Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red wine.
Cancer research 2008;68(3):946-55.
2008: Anna L Stratford; Christopher J Fry; Curtis Desilets; Alastair H Davies; Yong Y Cho; Yvonne Li; Zigang Dong; Isabelle M Berquin; Philippe Roux; Sandra E Dunn
Y-box binding protein-1 serine 102 is a downstream target of p90 ribosomal S6 kinase in basal-like breast cancer cells.
Breast cancer research : BCR 2008;10(6):R99.
2008: Margarita Malakhova; Valentina Tereshko; Sung-Young Lee; Ke Yao; Yong-Yeon Cho; Ann Bode; Zigang Dong
Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2.
Nature structural & molecular biology 2008;15(1):112-3.
2008: Hong Seok Choi; Bong Seok Kang; Jung-Hyun Shim; Yong-Yeon Cho; Bu Young Choi; Ann M Bode; Zigang Dong
Cot, a novel kinase of histone H3, induces cellular transformation through up-regulation of c-fos transcriptional activity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(1):113-26.
2007: Nam Joo Kang; Ki Won Lee; Evgeny Rogozin; Yong-Yeon Cho; Yong-Seok Heo; Ann M Bode; Hyong Joo Lee; Zigang Dong
Equol, a metabolite of the soybean isoflavone daidzein, inhibits neoplastic cell transformation by targeting the MEK/ERK/p90RSK/activator protein-1 pathway.
The Journal of biological chemistry 2007;282(45):32856-66.
2007: Ke Yao; Yong-Yeon Cho; H Robert Bergen; Benjamin J Madden; Bu Young Choi; Wei-Ya Ma; Ann M Bode; Zigang Dong
Nuclear factor of activated T3 is a negative regulator of Ras-JNK1/2-AP-1 induced cell transformation.
Cancer research 2007;67(18):8725-35.
2007: Yong-Yeon Cho; Ke Yao; Hong-Gyum Kim; Bong Seok Kang; Duo Zheng; Ann M Bode; Zigang Dong
Ribosomal S6 kinase 2 is a key regulator in tumor promoter induced cell transformation.
Cancer research 2007;67(17):8104-12.
2007: Ki Won Lee; Nam Joo Kang; Evgeny Rogozin; Hong-Gyum Kim; Yong-Yeon Cho; Ann M Bode; Hyong Joo Lee; Young-Joon Surh; George Bowden; Zigang Dong
Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1.
Carcinogenesis 2007;28(9):1918-27.
2007: Ann M Bode; Zigang Dong
The functional contrariety of JNK.
Molecular carcinogenesis 2007;46(8):591-8.
2007: Feng Zhu; Tatyana A Zykova; Bong Seok Kang; Zhe Wang; Mara C Ebeling; Yasuhito Abe; Wei-Ya Ma; Ann M Bode; Zigang Dong
Bidirectional signals transduced by TOPK-ERK interaction increase tumorigenesis of HCT116 colorectal cancer cells.
Gastroenterology 2007;133(1):219-31.
2007: Tatyana A Zykova; Feng Zhu; Yiguo Zhang; Ann M Bode; Zigang Dong
Involvement of ERKs, RSK2 and PKR in UVA-induced signal transduction toward phosphorylation of eIF2alpha (Ser(51)).
Carcinogenesis 2007;28(7):1543-51.
2007: Sergey N Fedorov; Larisa K Shubina; Ann M Bode; Valentin A Stonik; Zigang Dong
Dactylone inhibits epidermal growth factor-induced transformation and phenotype expression of human cancer cells and induces G1-S arrest and apoptosis.
Cancer research 2007;67(12):5914-20.
2007: Sang-Muk Oh; Feng Zhu; Yong-Yeon Cho; Ki Won Lee; Bong Seok Kang; Hong-Gyum Kim; Tatyana A Zykova; Ann M Bode; Zigang Dong
T-lymphokine-activated killer cell-originated protein kinase functions as a positive regulator of c-Jun-NH2-kinase 1 signaling and H-Ras-induced cell transformation.
Cancer research 2007;67(11):5186-94.
2007: Lun Song; Jingxia Li; Jianping Ye; Gang Yu; Jin Ding; Dongyun Zhang; Weiming Ouyang; Zigang Dong; Sung O Kim; Chuanshu Huang
p85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiation.
Molecular and cellular biology 2007;27(7):2713-31.
2007: Yong-Yeon Cho; Ke Yao; Ann M Bode; H Robert Bergen; Benjamin J Madden; Sang-Muk Oh; Svetlana Ermakova; Bong Seok Kang; Hong Seok Choi; Jung-Hyun Shim; Zigang Dong
RSK2 mediates muscle cell differentiation through regulation of NFAT3.
The Journal of biological chemistry 2007;282(11):8380-92.
2007: Ann M Bode; Zigang Dong
The enigmatic effects of caffeine in cell cycle and cancer.
Cancer letters 2007;247(1):26-39.
2007: Ming Li; Zhiwei He; Svetlana Ermakova; Duo Zheng; Faqing Tang; Yong-Yeon Cho; Feng Zhu; Wei-Ya Ma; Yuk Sham; Evgeny Rogozin; Ann M Bode; Ya Cao; Zigang Dong
Direct inhibition of insulin-like growth factor-I receptor kinase activity by (-)-epigallocatechin-3-gallate regulates cell transformation.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007;16(3):598-605.
2007: Guangrong Yan; Wei Luo; Zhongxin Lu; Xiangjian Luo; Lili Li; Sufang Liu; Yiping Liu; Min Tang; Zigang Dong; Ya Cao
Epstein-Barr virus latent membrane protein 1 mediates phosphorylation and nuclear translocation of annexin A2 by activating PKC pathway.
Cellular signalling 2007;19(2):341-8.
2006: Tatyana A Zykova; Feng Zhu; Chengrong Lu; LeeAnn Higgins; Yasuaki Tatsumi; Yasuhito Abe; Ann M Bode; Zigang Dong
Lymphokine-activated killer T-cell-originated protein kinase phosphorylation of histone H2AX prevents arsenite-induced apoptosis in RPMI7951 melanoma cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(23):6884-93.
2006: Faqing Tang; Guangming Liu; Zhiwei He; Wei-Ya Ma; Ann M Bode; Zigang Dong
Arsenite inhibits p53 phosphorylation, DNA binding activity, and p53 target gene p21 expression in mouse epidermal JB6 cells.
Molecular carcinogenesis 2006;45(11):861-70.
2006: Svetlana Ermakova; Bong Seok Kang; Bu Young Choi; Hong Seok Choi; Todd F Schuster; Wei-Ya Ma; Ann M Bode; Zigang Dong
(-)-Epigallocatechin gallate overcomes resistance to etoposide-induced cell death by targeting the molecular chaperone glucose-regulated protein 78.
Cancer research 2006;66(18):9260-9.
2006: Chengrong Lu; Feng Zhu; Yong-Yeon Cho; Faqing Tang; Tatyana A Zykova; Wei-Ya Ma; Ann M Bode; Zigang Dong
Cell apoptosis: requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3.
Molecular cell 2006;23(1):121-32.
2006: Yasuaki Tatsumi; Yong-Yeon Cho; Zhiwei He; Hideya Mizuno; Hong Seok Choi; Ann M Bode; Zigang Dong
Involvement of the paxillin pathway in JB6 Cl41 cell transformation.
Cancer research 2006;66(11):5968-74.
2006: Feng Zhu; Bu Young Choi; Wei-Ya Ma; Zhongliang Zhao; Yiguo Zhang; Yong-Yeon Cho; Hong Seok Choi; Akira Imamoto; Ann M Bode; Zigang Dong
COOH-terminal Src kinase-mediated c-Jun phosphorylation promotes c-Jun degradation and inhibits cell transformation.
Cancer research 2006;66(11):5729-36.
2006: Ann M Bode; Zigang Dong
Molecular and cellular targets.
Molecular carcinogenesis 2006;45(6):422-30.
2006: Zigang Dong; Ann M Bode
Proceedings--targeting carcinogenesis: transduction, transcription, translation.
Molecular carcinogenesis 2006;45(6):353-4.
2006: Zigang Dong; Ann M Bode
The role of histone H3 phosphorylation (Ser10 and Ser28) in cell growth and cell transformation.
Molecular carcinogenesis 2006;45(6):416-21.
2006: Guangrong Yan; Lili Li; Yongguang Tao; Sufang Liu; Yiping Liu; Wei Luo; Yong Wu; Min Tang; Zigang Dong; Ya Cao
Identification of novel phosphoproteins in signaling pathways triggered by latent membrane protein 1 using functional proteomics technology.
Proteomics 2006;6(6):1810-21.
2006: Hideya Mizuno; Yong-Yeon Cho; Feng Zhu; Wei-Ya Ma; Ann M Bode; Chung S Yang; Chi-Tang Ho; Zigang Dong
Theaflavin-3, 3'-digallate induces epidermal growth factor receptor downregulation.
Molecular carcinogenesis 2006;45(3):204-12.
2006: Sergey N Fedorov; Oleg S Radchenko; Larisa K Shubina; Nadezhda N Balaneva; Ann M Bode; Valentin A Stonik; Zigang Dong
Evaluation of cancer-preventive activity and structure-activity relationships of 3-demethylubiquinone Q2, isolated from the ascidian Aplidium glabrum, and its synthetic analogs.
Pharmaceutical research 2006;23(1):70-81.
2006: Hideya Mizuno; Yong-Yeon Cho; Wei-Ya Ma; Ann M Bode; Zigang Dong
Effects of MAP kinase inhibitors on epidermal growth factor-induced neoplastic transformation of human keratinocytes.
Molecular carcinogenesis 2006;45(1):1-9.
2005: Masaaki Nomura; Daisuke Ichimatsu; Shuzo Moritani; Ichiko Koyama; Zigang Dong; Koichi Yokogawa; Ken-Ichi Miyamoto
Inhibition of epidermal growth factor-induced cell transformation and Akt activation by caffeine.
Molecular carcinogenesis 2005;44(1):67-76.
2005: David Wan-Cheng Li; Jin-Ping Liu; Ying-Wei Mao; Hua Xiang; Juan Wang; Wei-Ya Ma; Zigang Dong; Helen M Pike; Rhoderick Brown; John C Reed
Calcium-activated RAF/MEK/ERK signaling pathway mediates p53-dependent apoptosis and is abrogated by alpha B-crystallin through inhibition of RAS activation.
Molecular biology of the cell 2005;16(9):4437-53.
2005: Bu Young Choi; Hong Seok Choi; Kwangseok Ko; Yong-Yeon Cho; Feng Zhu; Bong Seok Kang; Svetlana Ermakova; Wei-Ya Ma; Ann M Bode; Zigang Dong
The tumor suppressor p16(INK4a) prevents cell transformation through inhibition of c-Jun phosphorylation and AP-1 activity.
Nature structural & molecular biology 2005;12(8):699-707.
2005: Qing Zhao; Zhiwei He; Nanyue Chen; Yong-Yeon Cho; Feng Zhu; Chengrong Lu; Wei-Ya Ma; Ann M Bode; Zigang Dong
2-Arachidonoylglycerol stimulates activator protein-1-dependent transcriptional activity and enhances epidermal growth factor-induced cell transformation in JB6 P+ cells.
The Journal of biological chemistry 2005;280(29):26735-42.
2005: Hong Seok Choi; Bu Young Choi; Yong-Yeon Cho; Hideya Mizuno; Bong Seok Kang; Ann M Bode; Zigang Dong
Phosphorylation of histone H3 at serine 10 is indispensable for neoplastic cell transformation.
Cancer research 2005;65(13):5818-27.
2005: Yong-Yeon Cho; Zhiwei He; Yiguo Zhang; Hong Seok Choi; Feng Zhu; Bu Young Choi; Bong Seok Kang; Wei-Ya Ma; Ann M Bode; Zigang Dong
The p53 protein is a novel substrate of ribosomal S6 kinase 2 and a critical intermediary for ribosomal S6 kinase 2 and histone H3 interaction.
Cancer research 2005;65(9):3596-603.
2005: Svetlana Ermakova; Bu Young Choi; Hong Seok Choi; Bong Seok Kang; Ann M Bode; Zigang Dong
The intermediate filament protein vimentin is a new target for epigallocatechin gallate.
The Journal of biological chemistry 2005;280(17):16882-90.
2005: Ann M Bode; Zigang Dong
Inducible covalent posttranslational modification of histone H3.
Science's STKE : signal transduction knowledge environment 2005;2005(281):re4.
2005: Hong Seok Choi; Bu Young Choi; Yong-Yeon Cho; Feng Zhu; Ann M Bode; Zigang Dong
Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase alpha.
The Journal of biological chemistry 2005;280(14):13545-53.
2005: Zigang Dong; Christina W Hoven; Allan Rosenfield
Lessons from the past.
Nature 2005;433(7026):573-4.
2005: Tatyana A Zykova; Yiguo Zhang; Feng Zhu; Ann M Bode; Zigang Dong
The signal transduction networks required for phosphorylation of STAT1 at Ser727 in mouse epidermal JB6 cells in the UVB response and inhibitory mechanisms of tea polyphenols.
Carcinogenesis 2005;26(2):331-42.
2005: Zhiwei He; Yong-Yeon Cho; Wei-Ya Ma; Hong Seok Choi; Ann M Bode; Zigang Dong
Regulation of ultraviolet B-induced phosphorylation of histone H3 at serine 10 by Fyn kinase.
The Journal of biological chemistry 2005;280(4):2446-54.
2005: Ann M Bode; Zigang Dong
Signal transduction pathways in cancer development and as targets for cancer prevention.
Progress in nucleic acid research and molecular biology 2005;79():237-97.
2004: Jin-Ping Liu; Ryan Schlosser; Wei-Ya Ma; Zigang Dong; Hao Feng; Long Lui; Xiao-Qing Huang; Yan Liu; David Wan-Cheng Li
Human alphaA- and alphaB-crystallins prevent UVA-induced apoptosis through regulation of PKCalpha, RAF/MEK/ERK and AKT signaling pathways.
Experimental eye research 2004;79(6):393-403.
2004: Sergey N Fedorov; Ann M Bode; Valentin A Stonik; Irina A Gorshkova; Patricia C Schmid; Oleg S Radchenko; Evgeny Berdyshev; Zigang Dong
Marine alkaloid polycarpine and its synthetic derivative dimethylpolycarpine induce apoptosis in JB6 cells through p53- and caspase 3-dependent pathways.
Pharmaceutical research 2004;21(12):2307-19.
2004: A M Bode; Zigang Dong
Targeting signal transduction pathways by chemopreventive agents.
Mutation research 2004;555(1-2):33-51.
2004: Ann M Bode; Zigang Dong
Post-translational modification of p53 in tumorigenesis.
Nature reviews. Cancer 2004;4(10):793-805.
2004: Feng Zhu; Yiguo Zhang; Ann M Bode; Zigang Dong
Involvement of ERKs and mitogen- and stress-activated protein kinase in UVC-induced phosphorylation of ATF2 in JB6 cells.
Carcinogenesis 2004;25(10):1847-52.
2004: Jin-Ping Liu; Ryan Schlosser; Wei-Ya Ma; Zigang Dong; Hao Feng; Long Liu; Xiao-Qing Huang; Yan Liu; David Wan-Cheng Li
Human alphaA- and alphaB-crystallins prevent UVA-induced apoptosis through regulation of PKCalpha, RAF/MEK/ERK and AKT signaling pathways.
Experimental eye research 2004;79(3):393-403.
2004: Yiguo Zhang; Yong-Yeon Cho; Brandon L Petersen; Feng Zhu; Zigang Dong
Evidence of STAT1 phosphorylation modulated by MAPKs, MEK1 and MSK1.
Carcinogenesis 2004;25(7):1165-75.
2004: Yong-Yeon Cho; Ann M Bode; Hideya Mizuno; Bu Young Choi; Hong Seok Choi; Zigang Dong
A novel role for mixed-lineage kinase-like mitogen-activated protein triple kinase alpha in neoplastic cell transformation and tumor development.
Cancer research 2004;64(11):3855-64.
2004: Takashi Hashimoto; Zhiwei He; Wei-Ya Ma; Patricia C Schmid; Ann M Bode; Chung S Yang; Zigang Dong
Caffeine inhibits cell proliferation by G0/G1 phase arrest in JB6 cells.
Cancer research 2004;64(9):3344-9.
2004: Ann M Bode; Zigang Dong
Cancer prevention by food factors through targeting signal transduction pathways.
Nutrition (Burbank, Los Angeles County, Calif.) 2004;20(1):89-94.
2003: Zigang Dong; Ann M Bode
Dialogue between ERKs and JNKs: friendly or antagonistic?
Molecular interventions 2003;3(6):306-8.
2003: Masaaki Nomura; Zhiwei He; Ichiko Koyama; Wei-Ya Ma; Ken-ichi Miyamoto; Zigang Dong
Involvement of the Akt/mTOR pathway on EGF-induced cell transformation.
Molecular carcinogenesis 2003;38(1):25-32.
2003: Shuping Zhong; Hidemasa Goto; Masaki Inagaki; Zigang Dong
Phosphorylation at serine 28 and acetylation at lysine 9 of histone H3 induced by trichostatin A.
Oncogene 2003;22(34):5291-7.
2003: Zhiwei He; Wei-Ya Ma; Takashi Hashimoto; Ann M Bode; Chung S Yang; Zigang Dong
Induction of apoptosis by caffeine is mediated by the p53, Bax, and caspase 3 pathways.
Cancer research 2003;63(15):4396-401.
2003: Zhiwei He; Yong-Yeon Cho; Guangming Liu; Wei-Ya Ma; Ann M Bode; Zigang Dong
p38 Mitogen-activated protein kinase regulation of JB6 Cl41 cell transformation promoted by epidermal growth factor.
The Journal of biological chemistry 2003;278(29):26435-42.
2003: Zhanguo Gao; Aamir Zuberi; Michael Quon; Zigang Dong; Jianping Ye
Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases.
The Journal of biological chemistry 2003;278(27):24944-50.
2003: Akira Kaji; Yiguo Zhang; Masaaki Nomura; Ann M Bode; Wei-Ya Ma; Qing-Bai She; Zigang Dong
Pifithrin-alpha promotes p53-mediated apoptosis in JB6 cells.
Molecular carcinogenesis 2003;37(3):138-48.
2003: Shengmin Sang; Guangming Liu; Kan He; Nanqun Zhu; Zigang Dong; Qunyi Zheng; Robert T Rosen; Chi-Tang Ho
New unusual iridoids from the leaves of noni (Morinda citrifolia L.) show inhibitory effect on ultraviolet B-induced transcriptional activator protein-1 (AP-1) activity.
Bioorganic & medicinal chemistry 2003;11(12):2499-502.
2003: Yiguo Zhang; Yong-Yeon Cho; Brandon L Petersen; Ann M Bode; Feng Zhu; Zigang Dong
Ataxia telangiectasia mutated proteins, MAPKs, and RSK2 are involved in the phosphorylation of STAT3.
The Journal of biological chemistry 2003;278(15):12650-9.
2003: Qing-Bai She; Wei-Ya Ma; Mingfu Wang; Akira Kaji; Chi-Tang Ho; Zigang Dong
Inhibition of cell transformation by resveratrol and its derivatives: differential effects and mechanisms involved.
Oncogene 2003;22(14):2143-50.
2003: Zhiwei He; Wei-Ya Ma; Guangming Liu; Yiguo Zhang; Ann M Bode; Zigang Dong
Arsenite-induced phosphorylation of histone H3 at serine 10 is mediated by Akt1, extracellular signal-regulated kinase 2, and p90 ribosomal S6 kinase 2 but not mitogen- and stress-activated protein kinase 1.
The Journal of biological chemistry 2003;278(12):10588-93.
2003: Zigang Dong
Molecular mechanism of the chemopreventive effect of resveratrol.
Mutation research 2003;523-524():145-50.
2003: Ann M Park; Zigang Dong
Signal transduction pathways: targets for green and black tea polyphenols.
Journal of biochemistry and molecular biology 2003;36(1):66-77.
2003: Ann M Bode; Zigang Dong
Mitogen-activated protein kinase activation in UV-induced signal transduction.
Science's STKE : signal transduction knowledge environment 2003;2003(167):RE2.
2003: Guangming Liu; Wei-Ya Ma; Ann M Bode; Yiguo Zhang; Zigang Dong
NS-398 and piroxicam suppress UVB-induced activator protein 1 activity by mechanisms independent of cyclooxygenase-2.
The Journal of biological chemistry 2003;278(4):2124-30.
2002: Warner B Bair; Nancy Hart; Janine G Einspahr; Guangming Liu; Zigang Dong; David S Alberts; George Bowden
Inhibitory effects of sodium salicylate and acetylsalicylic acid on UVB-induced mouse skin carcinogenesis.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2002;11(12):1645-52.
2002: Zigang Dong
The molecular mechanisms of arsenic-induced cell transformation and apoptosis.
Environmental health perspectives 2002;110 Suppl 5():757-9.
2002: Qing-Bai She; Wei-Ya Ma; Shuping Zhong; Zigang Dong
Activation of JNK1, RSK2, and MSK1 is involved in serine 112 phosphorylation of Bad by ultraviolet B radiation.
The Journal of biological chemistry 2002;277(27):24039-48.
2002: Zigang Dong; Joan L Cmarik
Harvesting cells under anchorage-independent cell transformation conditions for biochemical analyses.
Science's STKE : signal transduction knowledge environment 2002;2002(130):pl7.
2002: Qing-Bai She; Chuanshu Huang; Yiguo Zhang; Zigang Dong
Involvement of c-jun NH(2)-terminal kinases in resveratrol-induced activation of p53 and apoptosis.
Molecular carcinogenesis 2002;33(4):244-50.
2002: Ann M Bode; Zigang Dong
The paradox of arsenic: molecular mechanisms of cell transformation and chemotherapeutic effects.
Critical reviews in oncology/hematology 2002;42(1):5-24.
2002: Guangming Liu; Yiguo Zhang; Ann M Bode; Wei-Ya Ma; Zigang Dong
Phosphorylation of 4E-BP1 is mediated by the p38/MSK1 pathway in response to UVB irradiation.
The Journal of biological chemistry 2002;277(11):8810-6.
2002: Qing-Bai She; Nanyue Chen; Ann M Bode; Richard A Flavell; Zigang Dong
Deficiency of c-Jun-NH(2)-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate.
Cancer research 2002;62(5):1343-8.
2002: Nanyue Chen; Qing-Bai She; Ann M Bode; Zigang Dong
Differential gene expression profiles of Jnk1- and Jnk2-deficient murine fibroblast cells.
Cancer research 2002;62(5):1300-4.
2002: Qing-Bai She; Wei-Ya Ma; Zigang Dong
Role of MAP kinases in UVB-induced phosphorylation of p53 at serine 20.
Oncogene 2002;21(10):1580-9.
2002: Yiguo Zhang; Wei-Ya Ma; Akira Kaji; Ann M Bode; Zigang Dong
Requirement of ATM in UVA-induced signaling and apoptosis.
The Journal of biological chemistry 2002;277(5):3124-31.
2001: N Chen; Wei-Ya Ma; Qing-Bai She; E Wu; G Liu; Ann M Bode; Zigang Dong
Transactivation of the epidermal growth factor receptor is involved in 12-O-tetradecanoylphorbol-13-acetate-induced signal transduction.
The Journal of biological chemistry 2001;276(50):46722-8.
2001: M Nomura; A Kaji; Z He; W Y Ma; K Miyamoto; C S Yang; Zigang Dong
Inhibitory mechanisms of tea polyphenols on the ultraviolet B-activated phosphatidylinositol 3-kinase-dependent pathway.
The Journal of biological chemistry 2001;276(49):46624-31.
2001: Yiguo Zhang; Zigang Dong; Ann M Bode; Wei-Ya Ma; Nanyue Chen; Z Dong
Induction of EGFR-dependent and EGFR-independent signaling pathways by ultraviolet A irradiation.
DNA and cell biology 2001;20(12):769-79.
2001: Evgeny Berdyshev; Patricia C Schmid; Randy J Krebsbach; C J Hillard; Chuanshu Huang; Nanyue Chen; Zigang Dong; Harald H O Schmid
Cannabinoid-receptor-independent cell signalling by N-acylethanolamines.
The Biochemical journal 2001;360(Pt 1):67-75.
2001: Yiguo Zhang; Guangming Liu; Zigang Dong
MSK1 and JNKs mediate phosphorylation of STAT3 in UVA-irradiated mouse epidermal JB6 cells.
The Journal of biological chemistry 2001;276(45):42534-42.
2001: N Chen; Wei-Ya Ma; Zigang Dong
Inhibition of arsenite-induced apoptosis by aspirin.
Anticancer research 2001;21(5):3247-51.
2001: G Liu; A Bode; Wei-Ya Ma; S Sang; Chi-Tang Ho; Zigang Dong
Two novel glycosides from the fruits of Morinda citrifolia (noni) inhibit AP-1 transactivation and cell transformation in the mouse epidermal JB6 cell line.
Cancer research 2001;61(15):5749-56.
2001: M Nomura; A Kaji; Wei-Ya Ma; S Zhong; G Liu; George Bowden; K I Miyamoto; Zigang Dong
Mitogen- and stress-activated protein kinase 1 mediates activation of Akt by ultraviolet B irradiation.
The Journal of biological chemistry 2001;276(27):25558-67.
2001: Nanyue Chen; Wei-Ya Ma; Zigang Dong
Inositol hexaphosphate inhibits ultraviolet B-induced signal transduction.
Molecular carcinogenesis 2001;31(3):139-44.
2001: G Liu; D M Bibus; A M Bode; Wei-Ya Ma; RT Holman; Zigang Dong
Omega 3 but not omega 6 fatty acids inhibit AP-1 activity and cell transformation in JB6 cells.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(13):7510-5.
2001: Yiguo Zhang; Zigang Dong; M Nomura; Shuping Zhong; Nanyue Chen; Ann M Bode; Z Dong
Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation.
The Journal of biological chemistry 2001;276(24):20913-23.
2001: M Nomura; Akira Kaji; W Ma; K Miyamoto; Zigang Dong
Suppression of cell transformation and induction of apoptosis by caffeic acid phenethyl ester.
Molecular carcinogenesis 2001;31(2):83-9.
2001: S Zhong; J A Quealy; Ann M Bode; M Nomura; A Kaji; Wei-Ya Ma; Zigang Dong
Organ-specific activation of activator protein-1 in transgenic mice by 12-o-tetradecanoylphorbol-13-acetate with different administration methods.
Cancer research 2001;61(10):4084-91.
2001: Nanyue Chen; M Nomura; Qing-Bai She; Wei-Ya Ma; Ann M Bode; L Wang; Richard A Flavell; Zigang Dong
Suppression of skin tumorigenesis in c-Jun NH(2)-terminal kinase-2-deficient mice.
Cancer research 2001;61(10):3908-12.
2001: G Liu; N Chen; A Kaji; A M Bode; C A Ryan; Zigang Dong
Proteinase inhibitors I and II from potatoes block UVB-induced AP-1 activity by regulating the AP-1 protein compositional patterns in JB6 cells.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(10):5786-91.
2001: Yiguo Zhang; Shuping Zhong; Zigang Dong; Nanyue Chen; Ann M Bode; W Ma; Z Dong
UVA induces Ser381 phosphorylation of p90RSK/MAPKAP-K1 via ERK and JNK pathways.
The Journal of biological chemistry 2001;276(18):14572-80.
2001: Shengmin Sang; K He; G Liu; Nanqun Zhu; Xiaofang Cheng; Mingfu Wang; Q Zheng; Zigang Dong; Geetha Ghai; Robert T Rosen; Chi-Tang Ho
A new unusual iridoid with inhibition of activator protein-1 (AP-1) from the leaves of Morinda citrifolia L.
Organic letters 2001;3(9):1307-9.
2001: Shuping Zhong; Yiguo Zhang; C Jansen; H Goto; M Inagaki; Zigang Dong
MAP kinases mediate UVB-induced phosphorylation of histone H3 at serine 28.
The Journal of biological chemistry 2001;276(16):12932-7.
2001: Yiguo Zhang; Peter Mattjus; Patricia C Schmid; Zigang Dong; Shuping Zhong; Wei-Ya Ma; Rhoderick Brown; Ann M Bode; Harald H O Schmid; Z Dong
Involvement of the acid sphingomyelinase pathway in uva-induced apoptosis.
The Journal of biological chemistry 2001;276(15):11775-82.
2001: Qing-Bai She; Ann M Bode; Wei-Ya Ma; NY Chen; Zigang Dong
Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase.
Cancer research 2001;61(4):1604-10.
2001: Ann M Bode; Wei-Ya Ma; Y J Surh; Zigang Dong
Inhibition of epidermal growth factor-induced cell transformation and activator protein 1 activation by [6]-gingerol.
Cancer research 2001;61(3):850-3.
2001: S P Zhong; Wei-Ya Ma; J A Quealy; Y Zhang; Zigang Dong
Organ-specific distribution of AP-1 in AP-1 luciferase transgenic mice during the maturation process.
American journal of physiology. Regulatory, integrative and comparative physiology 2001;280(2):R376-81.
2001: Evgeny Berdyshev; Patricia C Schmid; Randy J Krebsbach; T Kuwae; Chuanshu Huang; W Y Ma; Zigang Dong; Harald H O Schmid
Role of N-acylethanolamines in cell signaling.
World review of nutrition and dietetics 2001;88():207-14.
2001: Zigang Dong; M Nomura; C Huang; W Y Ma
Effects of tea polyphenols on the signal transduction pathways.
Advances in experimental medicine and biology 2001;492():55-67.
2001: Chuanshu Huang; Ann M Bode; NY Chen; Wei-Ya Ma; J Li; M Nomura; Zigang Dong
Transactivation of AP-1 in AP-1-luciferase reporter transgenic mice by arsenite and arsenate.
Anticancer research 2001;21(1A):261-7.
2000: Ann M Bode; Zigang Dong
Signal transduction pathways: targets for chemoprevention of skin cancer.
The lancet oncology 2000;1():181-8.
2000: M Nomura; W Ma; N Chen; Ann M Bode; Zigang Dong
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced NF-kappaB activation by tea polyphenols, (-)-epigallocatechin gallate and theaflavins.
Carcinogenesis 2000;21(10):1885-90.
2000: S P Zhong; Wei-Ya Ma; Zigang Dong
ERKs and p38 kinases mediate ultraviolet B-induced phosphorylation of histone H3 at serine 10.
The Journal of biological chemistry 2000;275(28):20980-4.
2000: Qing-Bai She; Nanyue Chen; Zigang Dong
ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiation.
The Journal of biological chemistry 2000;275(27):20444-9.
2000: M Nomura; Wei-Ya Ma; Chuanshu Huang; CS Yang; George Bowden; K Miyamoto; Zigang Dong
Inhibition of ultraviolet B-induced AP-1 activation by theaflavins from black tea.
Molecular carcinogenesis 2000;28(3):148-55.
2000: Chuanshu Huang; Peter Mattjus; Wei-Ya Ma; M Rincon; N Y Chen; Rhoderick Brown; Zigang Dong
Involvement of nuclear factor of activated T cells activation in UV response. Evidence from cell culture and transgenic mice.
The Journal of biological chemistry 2000;275(13):9143-9.
2000: Evgeny Berdyshev; Patricia C Schmid; Zigang Dong; Harald H O Schmid
Stress-induced generation of N-acylethanolamines in mouse epidermal JB6 P+ cells.
The Biochemical journal 2000;346 Pt 2():369-74.
2000: Chuanshu Huang; J Li; Nanyue Chen; W Ma; George Bowden; Zigang Dong
Inhibition of atypical PKC blocks ultraviolet-induced AP-1 activation by specifically inhibiting ERKs activation.
Molecular carcinogenesis 2000;27(2):65-75.
2000: Zigang Dong
Effects of food factors on signal transduction pathways.
BioFactors (Oxford, England) 2000;12(1-4):17-28.
2000: NY Chen; Wei-Ya Ma; Chuanshu Huang; M Ding; Zigang Dong
Activation of PKC is required for arsenite-induced signal transduction.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 2000;19(3):297-305.
2000: NY Chen; Wei-Ya Ma; CS Yang; Zigang Dong
Inhibition of arsenite-induced apoptosis and AP-1 activity by epigallocatechin-3-gallate and theaflavins.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 2000;19(3):287-95.
1999: Chuanshu Huang; J Li; Wei-Ya Ma; Zigang Dong
JNK activation is required for JB6 cell transformation induced by tumor necrosis factor-alpha but not by 12-O-tetradecanoylphorbol-13-acetate.
The Journal of biological chemistry 1999;274(42):29672-6.
1999: Zigang Dong; Chuanshu Huang; Wei-Ya Ma
PI-3 kinase in signal transduction, cell transformation, and as a target for chemoprevention of cancer.
Anticancer research 1999;19(5A):3743-7.
1999: Chuanshu Huang; Wei-Ya Ma; J Li; Zigang Dong
Arsenic induces apoptosis through a c-Jun NH2-terminal kinase-dependent, p53-independent pathway.
Cancer research 1999;59(13):3053-8.
1999: Nanyue Chen; Chuanshu Huang; W y Ma; Zigang Dong
Translocation of protein kinase Cepsilon and protein kinase Cdelta to membrane is required for ultraviolet B-induced activation of mitogen-activated protein kinases and apoptosis.
The Journal of biological chemistry 1999;274(22):15389-94.
1999: Chuanshu Huang; Wei-Ya Ma; J Li; A Goranson; Zigang Dong
Requirement of Erk, but not JNK, for arsenite-induced cell transformation.
The Journal of biological chemistry 1999;274(21):14595-601.
1999: Chuanshu Huang; Wei-Ya Ma; Zigang Dong
The extracellular-signal-regulated protein kinases (Erks) are required for UV-induced AP-1 activation in JB6 cells.
Oncogene 1999;18(18):2828-35.
1999: Chuanshu Huang; Wei-Ya Ma; A Maxiner; Yi Sun; Zigang Dong
p38 kinase mediates UV-induced phosphorylation of p53 protein at serine 389.
The Journal of biological chemistry 1999;274(18):12229-35.
1999: Weiming Chen; Zigang Dong; Susanne Valcic; Barbara N Timmermann; George Bowden
Inhibition of ultraviolet B--induced c-fos gene expression and p38 mitogen-activated protein kinase activation by (-)-epigallocatechin gallate in a human keratinocyte cell line.
Molecular carcinogenesis 1999;24(2):79-84.
1999: Chuanshu Huang; Wei-Ya Ma; A Goranson; Zigang Dong
Resveratrol suppresses cell transformation and induces apoptosis through a p53-dependent pathway.
Carcinogenesis 1999;20(2):237-42.
1998: M Barthelman; Warner B Bair; K K Stickland; Weiming Chen; Barbara N Timmermann; Susanne Valcic; Zigang Dong; George Bowden
(-)-Epigallocatechin-3-gallate inhibition of ultraviolet B-induced AP-1 activity.
Carcinogenesis 1998;19(12):2201-4.
1998: Weiming Chen; AH Borchers; Zigang Dong; Marianne Powell; George Bowden
UVB irradiation-induced activator protein-1 activation correlates with increased c-fos gene expression in a human keratinocyte cell line.
The Journal of biological chemistry 1998;273(48):32176-81.
1998: Zigang Dong; Chuanshu Huang; Wei-Ya Ma; Barbara Malewicz; Wolfgang J Baumann; Z Kiss
Increased synthesis of phosphocholine is required for UV-induced AP-1 activation.
Oncogene 1998;17(14):1845-53.
1998: Chuanshu Huang; N Chen; W Y Ma; Zigang Dong
Vanadium induces AP-1- and NFkappB-dependent transcription activity.
International journal of oncology 1998;13(4):711-5.
1998: Chuanshu Huang; Wei-Ya Ma; J Li; Stephen S Hecht; Zigang Dong
Essential role of p53 in phenethyl isothiocyanate-induced apoptosis.
Cancer research 1998;58(18):4102-6.
1998: Chuanshu Huang; Wei-Ya Ma; Zigang Dong
Potentiation of insulin-induced phosphatidylinositol-3 kinase activity by phorbol ester is mediated by protein kinase C epsilon.
Cellular signalling 1998;10(3):185-90.
1998: W Y Ma; Chuanshu Huang; Zigang Dong
Inhibition of ultraviolet C irradiation-induced AP-1 activity by aspirin is through inhibition of JNKs but not erks or P38 MAP kinase.
International journal of oncology 1998;12(3):565-8.
1998: M Barthelman; Weiming Chen; HL Gensler; C Huang; Zigang Dong; George Bowden
Inhibitory effects of perillyl alcohol on UVB-induced murine skin cancer and AP-1 transactivation.
Cancer research 1998;58(4):711-6.
1998: Chuanshu Huang; Wei-Ya Ma; M R Young; N Colburn; Zigang Dong
Shortage of mitogen-activated protein kinase is responsible for resistance to AP-1 transactivation and transformation in mouse JB6 cells.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(1):156-61.
1997: Chuanshu Huang; W y Ma; M Ding; George Bowden; Zigang Dong
Direct evidence for an important role of sphingomyelinase in ultraviolet-induced activation of c-Jun N-terminal kinase.
The Journal of biological chemistry 1997;272(44):27753-7.
1997: Chuanshu Huang; Wei-Ya Ma; C A Ryan; Zigang Dong
Proteinase inhibitors I and II from potatoes specifically block UV-induced activator protein-1 activation through a pathway that is independent of extracellular signal-regulated kinases, c-Jun N-terminal kinases, and P38 kinase.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(22):11957-62.
1997: Chuanshu Huang; Wei-Ya Ma; D Hanenberger; Margot P Cleary; George Bowden; Zigang Dong
Inhibition of ultraviolet B-induced activator protein-1 (AP-1) activity by aspirin in AP-1-luciferase transgenic mice.
The Journal of biological chemistry 1997;272(42):26325-31.
1997: Zigang Dong; W Ma; Chuanshu Huang; CS Yang
Inhibition of tumor promoter-induced activator protein 1 activation and cell transformation by tea polyphenols, (-)-epigallocatechin gallate, and theaflavins.
Cancer research 1997;57(19):4414-9.
1997: Chuanshu Huang; Wei-Ya Ma; Stephen S Hecht; Zigang Dong
Inositol hexaphosphate inhibits cell transformation and activator protein 1 activation by targeting phosphatidylinositol-3' kinase.
Cancer research 1997;57(14):2873-8.
1997: Chuanshu Huang; Wei-Ya Ma; M I Dawson; M Rincon; Richard A Flavell; Zigang Dong
Blocking activator protein-1 activity, but not activating retinoic acid response element, is required for the antitumor promotion effect of retinoic acid.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(11):5826-30.
1997: Chuanshu Huang; W Ma; Zigang Dong
Signal transduction through atypical PKCs, but not the EGF receptor, is necessary for UVC-induced AP-1 activation in immortal murine cells.
Oncogene 1997;14(16):1945-54.
1997: Z Kiss; B Guyer; Zigang Dong
Promotion-resistant JB6 mouse epidermal cells exhibit defects in phosphatidylethanolamine synthesis and phorbol ester-induced phosphatidylcholine hydrolysis.
The Biochemical journal 1997;323 ( Pt 2)():489-95.
1997: Zigang Dong; Chuanshu Huang; Rhoderick Brown; Wei-Ya Ma
Inhibition of activator protein 1 activity and neoplastic transformation by aspirin.
The Journal of biological chemistry 1997;272(15):9962-70.
1997: Chuanshu Huang; Patricia C Schmid; Wei-Ya Ma; Harald H O Schmid; Zigang Dong
Phosphatidylinositol-3 kinase is necessary for 12-O-tetradecanoylphorbol-13-acetate-induced cell transformation and activated protein 1 activation.
The Journal of biological chemistry 1997;272(7):4187-94.
1996: Chuanshu Huang; George Bowden; W y Ma; Zigang Dong
Ultraviolet B-induced activated protein-1 activation does not require epidermal growth factor receptor but is blocked by a dominant negative PKClambda/iota.
The Journal of biological chemistry 1996;271(49):31262-8.
1996: Chuanshu Huang; Wei-Ya Ma; Zigang Dong
Requirement for phosphatidylinositol 3-kinase in epidermal growth factor-induced AP-1 transactivation and transformation in JB6 P+ cells.
Molecular and cellular biology 1996;16(11):6427-35.
1996: Zigang Dong; RH Xu; J Kim; S N Zhan; Wei-Ya Ma; N H Colburn; H f Kung
AP-1/jun is required for early Xenopus development and mediates mesoderm induction by fibroblast growth factor but not by activin.
The Journal of biological chemistry 1996;271(17):9942-6.
1996: V Lavrovsky; Zigang Dong; Wei-Ya Ma; N Colburn
Drug-induced reversion of progression phenotype is accompanied by reversion of AP-1 phenotype in JB6 cells.
In vitro cellular & developmental biology. Animal 1996;32(4):234-7.
1996: RH Xu; Zigang Dong; M Maeno; J Kim; A Suzuki; N Ueno; D Sredni; N H Colburn; H F Kung
Involvement of Ras/Raf/AP-1 in BMP-4 signaling during Xenopus embryonic development.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(2):834-8.