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Louise Donnelly

Research Profile

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TOP 3
Rebecca A Holloway; Louise E Donnelly
Immunopathogenesis of chronic obstructive pulmonary disease.
Stephanie M Brown; Akira Koarai; Andrew G Nicholson; Richard G Sturton; Peter J Barnes; Louise E Donnelly
A role for M2 and M3 muscarinic receptors in the contraction of rat and human small airways.
Louise E Donnelly; Peter J Barnes
Defective phagocytosis in airways disease.

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All Publications

2013: Rebecca A Holloway; Louise E Donnelly
Immunopathogenesis of chronic obstructive pulmonary disease.
Current opinion in pulmonary medicine 2013;19(2):95-102.
2013: Stephanie M Brown; Akira Koarai; Andrew G Nicholson; Richard G Sturton; Peter J Barnes; Louise E Donnelly
A role for M2 and M3 muscarinic receptors in the contraction of rat and human small airways.
European journal of pharmacology 2013;702(1-3):109-15.
2012: Louise E Donnelly; Peter J Barnes
Defective phagocytosis in airways disease.
Chest 2012;141(4):1055-62.
2012: A Koarai; Andrew G Nicholson; Richard E K Russell; Suzanne L Traves; Peter J Barnes; S M Brown; K K Chana; Peter S Fenwick; Louise E Donnelly
Expression of muscarinic receptors by human macrophages.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2012;39(3):698-704.
2011: Nicolas Mercado; Rajesh K Thimmulappa; Catherine M R Thomas; Peter S Fenwick; Kirandeep K Chana; Louise E Donnelly; Shyam Biswal; Kazuhiro Ito; Peter J Barnes
Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress.
Biochemical and biophysical research communications 2011;406(2):292-8.
2010: Tricia K Finney-Hayward; Mariana Oana Popa; Parmjit Bahra; Su Li; Christopher T Poll; Martin Gosling; Andrew G Nicholson; Richard E K Russell; Onn Min Kon; Gabor Jarai; John Westwick; Peter J Barnes; Louise E Donnelly
Expression of transient receptor potential C6 channels in human lung macrophages.
American journal of respiratory cell and molecular biology 2010;43(3):296-304.
2010: Louise E Donnelly; S J Tudhope; P S Fenwick; Peter J Barnes
Effects of formoterol and salmeterol on cytokine release from monocyte-derived macrophages.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2010;36(1):178-86.
2010: A E Taylor; T K Finney-Hayward; J K Quint; C M R Thomas; S J Tudhope; Jadwiga A Wedzicha; Peter J Barnes; Louise E Donnelly
Defective macrophage phagocytosis of bacteria in COPD.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2010;35(5):1039-47.
2009: T K Finney-Hayward; P Bahra; S Li; C T Poll; Andrew G Nicholson; R E K Russell; P A Ford; John Westwick; P S Fenwick; Peter J Barnes; Louise E Donnelly
Leukotriene B4 release by human lung macrophages via receptor- not voltage-operated Ca2+ channels.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2009;33(5):1105-12.
2008: Suzanne L Traves; Louise E Donnelly
Th17 cells in airway diseases.
Current molecular medicine 2008;8(5):416-26.
2008: Louise E Donnelly; Duncan F Rogers
Novel targets and drugs in inflammatory lung disease.
Current opinion in pharmacology 2008;8(3):219-21.
2008: Claudia Costa; Rogério Rufino; Suzanne L Traves; José Roberto Lapa e Silva; Peter J Barnes; Louise E Donnelly
CXCR3 and CCR5 chemokines in induced sputum from patients with COPD.
Chest 2008;133(1):26-33.
2008: Susan J Tudhope; Tricia K Finney-Hayward; Andrew G Nicholson; Ruth J Mayer; Mary S Barnette; Peter J Barnes; Louise E Donnelly
Different mitogen-activated protein kinase-dependent cytokine responses in cells of the monocyte lineage.
The Journal of pharmacology and experimental therapeutics 2008;324(1):306-12.
2007: Susan J Tudhope; Matthew C Catley; Peter S Fenwick; Richard E K Russell; William L Rumsey; Robert Newton; Peter J Barnes; Louise E Donnelly
The role of IkappaB kinase 2, but not activation of NF-kappaB, in the release of CXCR3 ligands from IFN-gamma-stimulated human bronchial epithelial cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(9):6237-45.
2007: Sumalatha Grandhi; Louise E Donnelly; Duncan F Rogers
Phytoceuticals: the new 'physic garden' for asthma and chronic obstructive pulmonary disease.
Expert review of respiratory medicine 2007;1(2):227-46.
2007: Catherine R Gwilt; Louise E Donnelly; Duncan F Rogers
The non-neuronal cholinergic system in the airways: an unappreciated regulatory role in pulmonary inflammation?
Pharmacology & therapeutics 2007;115(2):208-22.
2006: Joanna E Chivers; Wei Gong; Elizabeth M King; Joachim Seybold; Judith C W Mak; Louise E Donnelly; Neil S Holden; Robert Newton
Analysis of the dissociated steroid RU24858 does not exclude a role for inducible genes in the anti-inflammatory actions of glucocorticoids.
Molecular pharmacology 2006;70(6):2084-95.
2006: Susan J Smith; Peter S Fenwick; Andrew G Nicholson; F Kirschenbaum; T K Finney-Hayward; Linda S Higgins; Mark A Giembycz; Peter J Barnes; Louise E Donnelly
Inhibitory effect of p38 mitogen-activated protein kinase inhibitors on cytokine release from human macrophages.
British journal of pharmacology 2006;149(4):393-404.
2006: Louise E Donnelly; Peter J Barnes
Chemokine receptors as therapeutic targets in chronic obstructive pulmonary disease.
Trends in pharmacological sciences 2006;27(10):546-53.
2005: Sarah V Culpitt; Duncan F Rogers; Suzanne L Traves; Peter J Barnes; Louise E Donnelly
Sputum matrix metalloproteases: comparison between chronic obstructive pulmonary disease and asthma.
Respiratory medicine 2005;99(6):703-10.
2005: Mark A Birrell; Kerryn McCluskie; Sissie Wong; Louise E Donnelly; Peter J Barnes; Maria G Belvisi
Resveratrol, an extract of red wine, inhibits lipopolysaccharide induced airway neutrophilia and inflammatory mediators through an NF-kappaB-independent mechanism.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(7):840-1.
2004: Susan J Smith; Lenora B Cieslinski; Robert Newton; Louise E Donnelly; Peter S Fenwick; Andrew G Nicholson; Peter J Barnes; Mary S Barnette; Mark A Giembycz
Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages, and CD8+ T-lymphocytes.
Molecular pharmacology 2004;66(6):1679-89.
2004: Joanna E Chivers; Lisa M Cambridge; Matthew C Catley; Judith C W Mak; Louise E Donnelly; Peter J Barnes; Robert Newton
Differential effects of RU486 reveal distinct mechanisms for glucocorticoid repression of prostaglandin E release.
European journal of biochemistry / FEBS 2004;271(20):4042-52.
2004: Louise E Donnelly; Peter J Barnes
Acidic mammalian chitinase--a potential target for asthma therapy.
Trends in pharmacological sciences 2004;25(10):509-11.
2004: Louise E Donnelly; Robert Newton; Gina E Kennedy; Peter S Fenwick; Rachel H F Leung; Kazuhiro Ito; Richard E K Russell; Peter J Barnes
Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms.
American journal of physiology. Lung cellular and molecular physiology 2004;287(4):L774-83.
2004: Ildikó Horváth; Louise E Donnelly; András Kiss; Beata Balint; Sergei A Kharitonov; Peter J Barnes
Exhaled nitric oxide and hydrogen peroxide concentrations in asthmatic smokers.
Respiration; international review of thoracic diseases 2004;71(5):463-8.
2004: Suzanne L Traves; Susan J Smith; Peter J Barnes; Louise E Donnelly
Specific CXC but not CC chemokines cause elevated monocyte migration in COPD: a role for CXCR2.
Journal of leukocyte biology 2004;76(2):441-50.
2003: Sarah V Culpitt; Duncan F Rogers; Peter S Fenwick; Pallav Shah; C J S de Matos; Richard E K Russell; Peter J Barnes; Louise E Donnelly
Inhibition by red wine extract, resveratrol, of cytokine release by alveolar macrophages in COPD.
Thorax 2003;58(11):942-6.
2003: Trevor T Hansel; Sergei A Kharitonov; Louise E Donnelly; Edward M Erin; Mark G Currie; William M Moore; Pamela T Manning; David P Recker; Peter J Barnes
A selective inhibitor of inducible nitric oxide synthase inhibits exhaled breath nitric oxide in healthy volunteers and asthmatics.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(10):1298-300.
2003: Elodie Nabeyrat; Gina E Jones; Peter S Fenwick; Peter J Barnes; Louise E Donnelly
Mitogen-activated protein kinases mediate peroxynitrite-induced cell death in human bronchial epithelial cells.
American journal of physiology. Lung cellular and molecular physiology 2003;284(6):L1112-20.
2003: Susan J Smith; Steven Brookes-Fazakerley; Louise E Donnelly; Peter J Barnes; Mary S Barnette; Mark A Giembycz
Ubiquitous expression of phosphodiesterase 7A in human proinflammatory and immune cells.
American journal of physiology. Lung cellular and molecular physiology 2003;284(2):L279-89.
2003: Louise E Donnelly; Duncan F Rogers
Therapy for chronic obstructive pulmonary disease in the 21st century.
Drugs 2003;63(19):1973-98.
2003: Sarah V Culpitt; Duncan F Rogers; Pallav Shah; C J S de Matos; Richard E K Russell; Louise E Donnelly; Peter J Barnes
Impaired inhibition by dexamethasone of cytokine release by alveolar macrophages from patients with chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 2003;167(1):24-31.
2002: Sergei A Kharitonov; Louise E Donnelly; Paolo Montuschi; Massimo Corradi; J V Collins; Peter J Barnes
Dose-dependent onset and cessation of action of inhaled budesonide on exhaled nitric oxide and symptoms in mild asthma.
Thorax 2002;57(10):889-96.
2002: Richard E K Russell; Andrew Thorley; Sarah V Culpitt; Sara Dodd; Louise E Donnelly; Carmen Demattos; Mary Fitzgerald; Peter J Barnes
Alveolar macrophage-mediated elastolysis: roles of matrix metalloproteinases, cysteine, and serine proteases.
American journal of physiology. Lung cellular and molecular physiology 2002;283(4):L867-73.
2002: PAUL EYNOTT; David A Groneberg; Gaetano Caramori; Ian M Adcock; Louise E Donnelly; Sergei A Kharitonov; Peter J Barnes; K Fan Chung
Role of nitric oxide in allergic inflammation and bronchial hyperresponsiveness.
European journal of pharmacology 2002;452(1):123-33.
2002: Suzanne L Traves; Sarah V Culpitt; Richard E K Russell; Peter J Barnes; Louise E Donnelly
Increased levels of the chemokines GROalpha and MCP-1 in sputum samples from patients with COPD.
Thorax 2002;57(7):590-5.
2002: Sarah V Culpitt; C J S de Matos; Richard E K Russell; Louise E Donnelly; Duncan F Rogers; Peter J Barnes
Effect of theophylline on induced sputum inflammatory indices and neutrophil chemotaxis in chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 2002;165(10):1371-6.
2002: Robert Newton; Jane Eddleston; El-Bdaoui Haddad; Samia Hawisa; Judith Mak; Sam Lim; Alison J Fox; Louise E Donnelly; K Fan Chung
Regulation of kinin receptors in airway epithelial cells by inflammatory cytokines and dexamethasone.
European journal of pharmacology 2002;441(3):193-202.
2002: Louise E Donnelly; Peter J Barnes
Expression and regulation of inducible nitric oxide synthase from human primary airway epithelial cells.
American journal of respiratory cell and molecular biology 2002;26(1):144-51.
2001: Ildikó Horváth; W MacNee; Frank Kelly; P N Dekhuijzen; M Phillips; G Döring; A M Choi; M Yamaya; F H Bach; D Willis; Louise E Donnelly; K F Chung; Peter J Barnes
"Haemoxygenase-1 induction and exhaled markers of oxidative stress in lung diseases", summary of the ERS Research Seminar in Budapest, Hungary, September, 1999.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2001;18(2):420-30.
2001: B Balint; Sergei A Kharitonov; Toyoyuki Hanazawa; Louise E Donnelly; Pallav L Shah; Margaret E Hodson; Peter J Barnes
Increased nitrotyrosine in exhaled breath condensate in cystic fibrosis.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2001;17(6):1201-7.
2001: B Balint; Louise E Donnelly; Toyoyuki Hanazawa; Sergei A Kharitonov; Peter J Barnes
Increased nitric oxide metabolites in exhaled breath condensate after exposure to tobacco smoke.
Thorax 2001;56(6):456-61.
2001: Massimo Corradi; Paolo Montuschi; Louise E Donnelly; Alberto Pesci; Sergei A Kharitonov; Peter J Barnes
Increased nitrosothiols in exhaled breath condensate in inflammatory airway diseases.
American journal of respiratory and critical care medicine 2001;163(4):854-8.
2001: PA Finney; Louise E Donnelly; Maria G Belvisi; Tsu Tshen Chuang; Mark A Birrell; A Harris; Judith C W Mak; CA Scorer; Peter J Barnes; Ian M Adcock; Mark A Giembycz
Chronic systemic administration of salmeterol to rats promotes pulmonary beta(2)-adrenoceptor desensitization and down-regulation of G(s alpha).
British journal of pharmacology 2001;132(6):1261-70.
2001: Louise E Donnelly; Peter J Barnes
Expression of heme oxygenase in human airway epithelial cells.
American journal of respiratory cell and molecular biology 2001;24(3):295-303.
2000: Julia A Nightingale; R Maggs; P Cullinan; Louise E Donnelly; Duncan F Rogers; R Kinnersley; K Fan Chung; Peter J Barnes; M Ashmore; A Newman-Taylor
Airway inflammation after controlled exposure to diesel exhaust particulates.
American journal of respiratory and critical care medicine 2000;162(1):161-6.
2000: PA Finney; Maria G Belvisi; Louise E Donnelly; Tsu Tshen Chuang; Judith C W Mak; CA Scorer; Peter J Barnes; Ian M Adcock; Mark A Giembycz
Albuterol-induced downregulation of Gsalpha accounts for pulmonary beta(2)-adrenoceptor desensitization in vivo.
The Journal of clinical investigation 2000;106(1):125-35.
1999: Hema J Patel; Maria G Belvisi; Louise E Donnelly; Magdi H Yacoub; K Fan Chung; Jane A Mitchell
Constitutive expressions of type I NOS in human airway smooth muscle cells: evidence for an antiproliferative role.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(13):1810-6.
1998: Ildikó Horváth; Louise E Donnelly; A Kiss; Sergei A Kharitonov; Sam Lim; K Fan Chung; Peter J Barnes
Combined use of exhaled hydrogen peroxide and nitric oxide in monitoring asthma.
American journal of respiratory and critical care medicine 1998;158(4):1042-6.
1998: Ildikó Horváth; Louise E Donnelly; A Kiss; Paolo Paredi; Sergei A Kharitonov; Peter J Barnes
Raised levels of exhaled carbon monoxide are associated with an increased expression of heme oxygenase-1 in airway macrophages in asthma: a new marker of oxidative stress.
Thorax 1998;53(8):668-72.
1998: Robert Newton; LA Hart; DA Stevens; M Bergmann; Louise E Donnelly; Ian M Adcock; Peter J Barnes
Effect of dexamethasone on interleukin-1beta-(IL-1beta)-induced nuclear factor-kappaB (NF-kappaB) and kappaB-dependent transcription in epithelial cells.
European journal of biochemistry / FEBS 1998;254(1):81-9.