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Alejandro Dopico

Research Profile

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Protein Structure, Tertiary

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Publications

TOP 3
Anna N Bukiya; Alexander L Fedinec; Charles W Leffler; Jacob E McMillan; Duane D Miller; Abby L Parrill; Shivaputra A Patil; Alejandro M Dopico
Cerebrovascular Dilation via Selective Targeting of the Cholane Steroid-Recognition Site in the BK Channel β1-Subunit by a Novel Nonsteroidal Agent.
Jianxi Liu; Aditya K Singh; Anna N Bukiya; Guruprasad Kuntamallappanavar; Alejandro M Dopico
Distinct sensitivity of slo1 channel proteins to ethanol.
Anna N Bukiya; Wei Li; Duane D Miller; Shivaputra A Patil; Alejandro M Dopico
Calcium- and voltage-gated potassium (BK) channel activators in the 5β-cholanic acid-3α-ol analogue series with modifications in the lateral chain.

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All Publications

2013: Anna N Bukiya; Alexander L Fedinec; Charles W Leffler; Jacob E McMillan; Duane D Miller; Abby L Parrill; Shivaputra A Patil; Alejandro M Dopico
Cerebrovascular Dilation via Selective Targeting of the Cholane Steroid-Recognition Site in the BK Channel β1-Subunit by a Novel Nonsteroidal Agent.
Molecular pharmacology 2013;83(5):1030-44.
2013: Jianxi Liu; Aditya K Singh; Anna N Bukiya; Guruprasad Kuntamallappanavar; Alejandro M Dopico
Distinct sensitivity of slo1 channel proteins to ethanol.
Molecular pharmacology 2013;83(1):235-44.
2012: Anna N Bukiya; Wei Li; Duane D Miller; Shivaputra A Patil; Alejandro M Dopico
Calcium- and voltage-gated potassium (BK) channel activators in the 5β-cholanic acid-3α-ol analogue series with modifications in the lateral chain.
ChemMedChem 2012;7(10):1784-92.
2012: Alejandro M Dopico; Anna N Bukiya; Aditya K Singh
Large conductance, calcium- and voltage-gated potassium (BK) channels: regulation by cholesterol.
Pharmacology & therapeutics 2012;135(2):133-50.
2012: Aditya K Singh; Anna N Bukiya; Brittany Burton; Jacob McMillan; Abby L Parrill; Alejandro M Dopico
Multiple cholesterol recognition/interaction amino acid consensus (CRAC) motifs in cytosolic C tail of Slo1 subunit determine cholesterol sensitivity of Ca2+- and voltage-gated K+ (BK) channels.
The Journal of biological chemistry 2012;287(24):20509-21.
2011: Anna N Bukiya; Guruprasad Kuntamallappanavar; Thirumalini Vaithianathan; Maria Asuncion-Chin; Alejandro M Dopico
Smooth muscle cholesterol enables BK β1 subunit-mediated channel inhibition and subsequent vasoconstriction evoked by alcohol.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(11):2410-23.
2011: Anna N Bukiya; Jitendra D Belani; Scott Rychnovsky; Alejandro M Dopico
Specificity of cholesterol and analogs to modulate BK channels points to direct sterol-channel protein interactions.
The Journal of general physiology 2011;137(1):93-110.
2010: Thirumalini Vaithianathan; Damodaran Narayanan; Maria T Asuncion-Chin; Loice H Jeyakumar; Jianxi Liu; Sidney Fleischer; Jonathan H Jaggar; Alejandro M Dopico
Subtype identification and functional characterization of ryanodine receptors in rat cerebral artery myocytes.
American journal of physiology. Cell physiology 2010;299(2):C264-78.
2009: Anna N Bukiya; Thirumalini Vaithianathan; Ligia Toro; Alejandro M Dopico
Channel beta2-4 subunits fail to substitute for beta1 in sensitizing BK channels to lithocholate.
Biochemical and biophysical research communications 2009;390(3):995-1000.
2009: Anna N Bukiya; Jianxi Liu; Alejandro M Dopico
The BK channel accessory beta1 subunit determines alcohol-induced cerebrovascular constriction.
FEBS letters 2009;583(17):2779-84.
2009: Xiaoyang Cheng; Judith Pachuau; Eva Blaskova; Maria Asuncion-Chin; Jianxi Liu; Alejandro M Dopico; Jonathan H Jaggar
Alternative splicing of Cav1.2 channel exons in smooth muscle cells of resistance-size arteries generates currents with unique electrophysiological properties.
American journal of physiology. Heart and circulatory physiology 2009;297(2):H680-8.
2009: Patrick J Mulholland; F Woodward Hopf; Anna N Bukiya; Gilles E Martin; Jianxi Liu; Alejandro M Dopico; Antonello Bonci; Steven N Treistman; L Judson Chandler
Sizing up ethanol-induced plasticity: the role of small and large conductance calcium-activated potassium channels.
Alcoholism, clinical and experimental research 2009;33(7):1125-35.
2008: Anna N Bukiya; Jacob McMillan; Abby L Parrill; Alejandro M Dopico
Structural determinants of monohydroxylated bile acids to activate beta 1 subunit-containing BK channels.
Journal of lipid research 2008;49(11):2441-51.
2008: Jianxi Liu; Thirumalini Vaithianathan; Kandiah Manivannan; Abby L Parrill; Alejandro M Dopico
Ethanol modulates BKCa channels by acting as an adjuvant of calcium.
Molecular pharmacology 2008;74(3):628-40.
2008: Shivaputra Patil; Anna N Bukiya; Wei Li; Alejandro M Dopico; Duane Miller
Design and synthesis of hydroxy-alkynoic acids and their methyl esters as novel activators of BK channels.
Bioorganic & medicinal chemistry letters 2008;18(11):3427-30.
2008: Anna N Bukiya; Thirumalini Vaithianathan; Ligia Toro; Alejandro M Dopico
The second transmembrane domain of the large conductance, voltage- and calcium-gated potassium channel beta(1) subunit is a lithocholate sensor.
FEBS letters 2008;582(5):673-8.
2007: Xiaoyang Cheng; Jianxi Liu; Maria Asuncion-Chin; Eva Blaskova; John P Bannister; Alejandro M Dopico; Jonathan H Jaggar
A novel Ca(V)1.2 N terminus expressed in smooth muscle cells of resistance size arteries modifies channel regulation by auxiliary subunits.
The Journal of biological chemistry 2007;282(40):29211-21.
2007: Mark S Brodie; Andreas Scholz; Thomas M Weiger; Alejandro M Dopico
Ethanol interactions with calcium-dependent potassium channels.
Alcoholism, clinical and experimental research 2007;31(10):1625-32.
2007: Anna N Bukiya; Jianxi Liu; Ligia Toro; Alejandro M Dopico
Beta1 (KCNMB1) subunits mediate lithocholate activation of large-conductance Ca2+-activated K+ channels and dilation in small, resistance-size arteries.
Molecular pharmacology 2007;72(2):359-69.
2006: Angelo M Del Re; Alejandro M Dopico; John J Woodward
Effects of the abused inhalant toluene on ethanol-sensitive potassium channels expressed in oocytes.
Brain research 2006;1087(1):75-82.
2006: Jianxi Liu; Maria Asuncion-Chin; Pengchong Liu; Alejandro M Dopico
CaM kinase II phosphorylation of slo Thr107 regulates activity and ethanol responses of BK channels.
Nature neuroscience 2006;9(1):41-9.
2005: Jonathan H Jaggar; Anlong Li; Helena Parfenova; Jianxi Liu; Edward S Umstot; Alejandro M Dopico; Charles W Leffler
Heme is a carbon monoxide receptor for large-conductance Ca2+-activated K+ channels.
Circulation research 2005;97(8):805-12.
2005: John J Crowley; Steven N Treistman; Alejandro M Dopico
Distinct structural features of phospholipids differentially determine ethanol sensitivity and basal function of BK channels.
Molecular pharmacology 2005;68(1):4-10.
2004: Pengchong Liu; Qi Xi; Abu Ahmed; Jonathan H Jaggar; Alejandro M Dopico
Essential role for smooth muscle BK channels in alcohol-induced cerebrovascular constriction.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(52):18217-22.
2003: Pengchong Liu; Jianxi Liu; Weihua Huang; Ming D Li; Alejandro M Dopico
Distinct regions of the slo subunit determine differential BKCa channel responses to ethanol.
Alcoholism, clinical and experimental research 2003;27(10):1640-4.
2003: John J Crowley; Steven N Treistman; Alejandro M Dopico
Cholesterol antagonizes ethanol potentiation of human brain BKCa channels reconstituted into phospholipid bilayers.
Molecular pharmacology 2003;64(2):365-72.
2003: Alejandro M Dopico
Ethanol sensitivity of BK(Ca) channels from arterial smooth muscle does not require the presence of the beta 1-subunit.
American journal of physiology. Cell physiology 2003;284(6):C1468-80.
2002: Thomas K Knott; Alejandro M Dopico; Govindan Dayanithi; José R Lemos; Steven N Treistman
Integrated channel plasticity contributes to alcohol tolerance in neurohypophysial terminals.
Molecular pharmacology 2002;62(1):135-42.
2002: Alejandro M Dopico; John V Walsh; Joshua J Singer
Natural bile acids and synthetic analogues modulate large conductance Ca2+-activated K+ (BKCa) channel activity in smooth muscle cells.
The Journal of general physiology 2002;119(3):251-73.
2000: Keith Tully; D Kupfer; Alejandro M Dopico; Steven N Treistman
A plasticizer released from IV drip chambers elevates calcium levels in neurosecretory terminals.
Toxicology and applied pharmacology 2000;168(3):183-8.
1999: Alejandro M Dopico; H Widmer; Gang Wang; José R Lemos; Steven N Treistman
Rat supraoptic magnocellular neurones show distinct large conductance, Ca2+-activated K+ channel subtypes in cell bodies versus nerve endings.
The Journal of physiology 1999;519 Pt 1():101-14.
1999: Alejandro M Dopico; B Chu; José R Lemos; Steven N Treistman
Alcohol modulation of calcium-activated potassium channels.
Neurochemistry international 1999;35(2):103-6.
1998: B Chu; Alejandro M Dopico; José R Lemos; Steven N Treistman
Ethanol potentiation of calcium-activated potassium channels reconstituted into planar lipid bilayers.
Molecular pharmacology 1998;54(2):397-406.
1998: Alejandro M Dopico; V Anantharam; Steven N Treistman
Ethanol increases the activity of Ca(++)-dependent K+ (mslo) channels: functional interaction with cytosolic Ca++.
The Journal of pharmacology and experimental therapeutics 1998;284(1):258-68.
1997: Alejandro M Dopico; Steven N Treistman
A novel large conductance, nonselective cation channel in pheochromocytoma (PC12) cells.
The Journal of membrane biology 1997;160(2):151-60.
1996: Alejandro M Dopico; José R Lemos; Steven N Treistman
Ethanol increases the activity of large conductance, Ca(2+)-activated K+ channels in isolated neurohypophysial terminals.
Molecular pharmacology 1996;49(1):40-8.
1995: S Petrou; R W Ordway; M T Kirber; Alejandro M Dopico; J A Hamilton; John V Walsh; Joshua J Singer
Direct effects of fatty acids and other charged lipids on ion channel activity in smooth muscle cells.
Prostaglandins, leukotrienes, and essential fatty acids 1995;52(2-3):173-8.
1994: Alejandro M Dopico; M T Kirber; Joshua J Singer; John V Walsh
Membrane stretch directly activates large conductance Ca(2+)-activated K+ channels in mesenteric artery smooth muscle cells.
American journal of hypertension 1994;7(1):82-9.