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Gerald Dorn

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All Publications

2013: Gerald W Dorn
miR-34a and the Cardiomyopathy of Senescence: SALT PNUTS, SALT PNUTS!
Cell metabolism 2013;17(5):629-30.
2013: Yun Chen; Gerald W Dorn
PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria.
Science (New York, N.Y.) 2013;340(6131):471-5.
2013: Gerald W Dorn
MicroRNAs and the butterfly effect.
Cell cycle (Georgetown, Tex.) 2013;12(5):707-8.
2013: Gerald W Dorn
Molecular mechanisms that differentiate apoptosis from programmed necrosis.
Toxicologic pathology 2013;41(2):227-34.
2013: Gerald W Dorn; Christoph Maack
SR and mitochondria: calcium cross-talk between kissing cousins.
Journal of molecular and cellular cardiology 2013;55():42-9.
2013: Gerald W Dorn
Mitochondrial dynamics in heart disease.
Biochimica et biophysica acta 2013;1833(1):233-41.
2012: Yuanxin Hu; Scot J Matkovich; Yan Zhang; John R Edwards; Peter A Hecker; Gerald W Dorn
Epitranscriptional orchestration of genetic reprogramming is an emergent property of stress-regulated cardiac microRNAs.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(48):19864-9.
2012: Sharon Cresci; Gerald W Dorn; Philip G Jones; Petra A Lenzini; Allie Y Li; Michael A Province; John A Spertus; Amber L Beitelshees; David E Lanfear
Adrenergic-pathway gene variants influence beta-blocker-related outcomes after acute coronary syndrome in a race-specific manner.
Journal of the American College of Cardiology 2012;60(10):898-907.
2012: Gerald W Dorn
Inflame on!: mitochondrial escape provokes cytokine storms that doom the heart.
Circulation research 2012;111(3):271-3.
2012: Danielle Glick; Michaela Gruber; John Hart; Michelle Beaton; Matthew J Brady; Gerald W Dorn; Glenn Marsboom; M Celeste Simon; Wenshuo Zhang; Kay F Macleod
BNip3 regulates mitochondrial function and lipid metabolism in the liver.
Molecular and cellular biology 2012;32(13):2570-84.
2012: Gerald W Dorn
Resolving a catch-22 in cardiac gene regulation.
Circulation 2012;125(22):2695-7.
2012: Gerald W Dorn
Decoding the cardiac message: the 2011 Thomas W. Smith Memorial Lecture.
Circulation research 2012;110(5):755-63.
2012: William H Eschenbacher; Casey C Jowdy; Moshi Song; Peter Zhao; Poonam Bhandari; Yun Chen; John T Engelhard; Gerald W Dorn
Two rare human mitofusin 2 mutations alter mitochondrial dynamics and induce retinal and cardiac pathology in Drosophila.
PloS one 2012;7(9):e44296.
2011: Yan Zhang; Xiujun Duan; Jessica I Gold; Walter J Koch; Scot J Matkovich; Gerald W Dorn
Nuclear effects of G-protein receptor kinase 5 on histone deacetylase 5-regulated gene transcription in heart failure.
Circulation. Heart failure 2011;4(5):659-68.
2011: Yan Zhang; Abhinav Diwan; Xiujun Duan; Min-Young Kang; Scot J Matkovich; Gerald W Dorn
Receptor-independent protein kinase C alpha (PKCalpha) signaling by calpain-generated free catalytic domains induces HDAC5 nuclear export and regulates cardiac transcription.
The Journal of biological chemistry 2011;286(30):26943-51.
2011: Gerald W Dorn
The genomic architecture of sporadic heart failure.
Circulation research 2011;108(10):1270-83.
2011: Gerald W Dorn
Genetics of common forms of heart failure.
Current opinion in cardiology 2011;26(3):204-8.
2011: Gerald W Dorn
MicroRNAs in cardiac disease.
Translational research : the journal of laboratory and clinical medicine 2011;157(4):226-35.
2011: Gerald W Dorn; Charles F Clark; William H Eschenbacher; Min-Young Kang; John T Engelhard; Stephen J Warner; Scot J Matkovich; Casey C Jowdy
MARF and Opa1 control mitochondrial and cardiac function in Drosophila.
Circulation research 2011;108(1):12-7.
2011: Scot J Matkovich; Derek J Van Booven; William H Eschenbacher; Gerald W Dorn
RISC RNA sequencing for context-specific identification of in vivo microRNA targets.
Circulation research 2011;108(1):18-26.
2010: Gerald W Dorn
MicroRNAs: redefining mechanisms in cardiac disease.
Journal of cardiovascular pharmacology 2010;56(6):589-95.
2010: Min-Young Kang; Yan Zhang; Scot J Matkovich; Abhinav Diwan; Athar H Chishti; Gerald W Dorn
Receptor-independent cardiac protein kinase Calpha activation by calpain-mediated truncation of regulatory domains.
Circulation research 2010;107(7):903-12.
2010: Gerald W Dorn; LUCA SCORRANO
Two close, too close: sarcoplasmic reticulum-mitochondrial crosstalk and cardiomyocyte fate.
Circulation research 2010;107(6):689-99.
2010: Gerald W Dorn
Mechanisms of non-apoptotic programmed cell death in diabetes and heart failure.
Cell cycle (Georgetown, Tex.) 2010;9(17):3442-8.
2010: Gerald W Dorn
Mitochondrial pruning by Nix and BNip3: an essential function for cardiac-expressed death factors.
Journal of cardiovascular translational research 2010;3(4):374-83.
2010: Kei Fujimoto; Yun Chen; Kenneth S Polonsky; Gerald W Dorn
Targeting cyclophilin D and the mitochondrial permeability transition enhances beta-cell survival and prevents diabetes in Pdx1 deficiency.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(22):10214-9.
2010: Yun Chen; William Lewis; Abhinav Diwan; Emily Cheng; Scot J Matkovich; Gerald W Dorn
Dual autonomous mitochondrial cell death pathways are activated by Nix/BNip3L and induce cardiomyopathy.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(20):9035-42.
2010: Scot J Matkovich; Yan Zhang; Derek J Van Booven; Gerald W Dorn
Deep mRNA sequencing for in vivo functional analysis of cardiac transcriptional regulators: application to Galphaq.
Circulation research 2010;106(9):1459-67.
2010: Gerald W Dorn
Therapeutic potential of microRNAs in heart failure.
Current cardiology reports 2010;12(3):209-15.
2010: Gerald W Dorn
Medicine. Refugee receptors switch sides.
Science (New York, N.Y.) 2010;327(5973):1586-7.
2010: Scot J Matkovich; Wei Wang; Yizheng Tu; William H Eschenbacher; Lisa E Dorn; Gianluigi Condorelli; Abhinav Diwan; Jeanne M Nerbonne; Gerald W Dorn
MicroRNA-133a protects against myocardial fibrosis and modulates electrical repolarization without affecting hypertrophy in pressure-overloaded adult hearts.
Circulation research 2010;106(1):166-75.
2010: Sharon Cresci; Janice M Huss; Amber L Beitelshees; Philip G Jones; Matt R Minton; Gerald W Dorn; Daniel P Kelly; John A Spertus; Howard L McLeod
A PPARα promoter variant impairs ERR-dependent transactivation and decreases mortality after acute coronary ischemia in patients with diabetes.
PloS one 2010;5(9):e12584.
2010: Scot J Matkovich; Derek J Van Booven; Anna Hindes; Min Young Kang; Todd E Druley; Francesco L M Vallania; Robi D Mitra; Muredach P Reilly; Thomas P Cappola; Gerald W Dorn
Cardiac signaling genes exhibit unexpected sequence diversity in sporadic cardiomyopathy, revealing HSPB7 polymorphisms associated with disease.
The Journal of clinical investigation 2010;120(1):280-9.
2009: Gerald W Dorn
Pharmacogenetic profiling in the treatment of heart disease.
Translational research : the journal of laboratory and clinical medicine 2009;154(6):295-302.
2009: Gerald W Dorn; Stephen B Liggett
Mechanisms of pharmacogenomic effects of genetic variation within the cardiac adrenergic network in heart failure.
Molecular pharmacology 2009;76(3):466-80.
2009: Sharon Cresci; Reagan J Kelly; Thomas P Cappola; Abhinav Diwan; Daniel Dries; Sharon L R Kardia; Gerald W Dorn
Clinical and genetic modifiers of long-term survival in heart failure.
Journal of the American College of Cardiology 2009;54(5):432-44.
2009: Gerald W Dorn
GRK mythology: G-protein receptor kinases in cardiovascular disease.
Journal of molecular medicine (Berlin, Germany) 2009;87(5):455-63.
2009: Gerald W Dorn
Novel pharmacotherapies to abrogate postinfarction ventricular remodeling.
Nature reviews. Cardiology 2009;6(4):283-91.
2009: Scot J Matkovich; Derek J Van Booven; Keith A Youker; Guillermo Torre Amione; Abhinav Diwan; William H Eschenbacher; Lisa E Dorn; Mark A Watson; Kenneth B Margulies; Gerald W Dorn
Reciprocal regulation of myocardial microRNAs and messenger RNA in human cardiomyopathy and reversal of the microRNA signature by biomechanical support.
Circulation 2009;119(9):1263-71.
2009: Abhinav Diwan; Scot J Matkovich; Qunying Yuan; Wen Zhao; Atsuko Yatani; Joan Heller Brown; Jeffery D Molkentin; Evangelia G Kranias; Gerald W Dorn
Endoplasmic reticulum-mitochondria crosstalk in NIX-mediated murine cell death.
The Journal of clinical investigation 2009;119(1):203-12.
2009: Guoli Chen; Xiaoyang Zhou; Anand Pathak; Gerald W Dorn; Evangelia G Kranias
The human G147D-protein phosphatase 1 inhibitor-1 polymorphism is not associated with altered clinical characteristics in heart failure.
Cardiology 2009;112(3):224-31.
2008: Demetrios A Arvanitis; Despina Sanoudou; Fotis Kolokathis; Elizabeth Vafiadaki; Vasiliki Papalouka; Aikaterini Kontrogianni-Konstantopoulos; George N Theodorakis; Ioannis A Paraskevaidis; Stamatios Adamopoulos; Gerald W Dorn; Dimitrios Th Kremastinos; Evangelia G Kranias
The Ser96Ala variant in histidine-rich calcium-binding protein is associated with life-threatening ventricular arrhythmias in idiopathic dilated cardiomyopathy.
European heart journal 2008;29(20):2514-25.
2008: Abhinav Diwan; Andrew G Koesters; Devan Capella; Hartmut Geiger; Theodosia A Kalfa; Gerald W Dorn
Targeting erythroblast-specific apoptosis in experimental anemia.
Apoptosis : an international journal on programmed cell death 2008;13(8):1022-30.
2008: Gerald W Dorn; Scot J Matkovich
Put your chips on transcriptomics.
Circulation 2008;118(3):216-8.
2008: Guoli Chen; Xiaoyang Zhou; Persoulla Nicolaou; Patricia Rodriguez; Guojie Song; Bryan Mitton; Anand Pathak; Amit Zachariah; Guo-Chang Fan; Gerald W Dorn; Evangelia G Kranias
A human polymorphism of protein phosphatase-1 inhibitor-1 is associated with attenuated contractile response of cardiomyocytes to beta-adrenergic stimulation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(6):1790-6.
2008: Stephen B Liggett; Sharon Cresci; Reagan J Kelly; Faisal M Syed; Scot J Matkovich; Harvey S Hahn; Abhinav Diwan; Jeffrey S Martini; Li Sparks; Rohan R Parekh; John A Spertus; Walter J Koch; Sharon L R Kardia; Gerald W Dorn
A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure.
Nature medicine 2008;14(5):510-7.
2008: Kobra Haghighi; Guoli Chen; Yoji Sato; Guo-Chang Fan; Suiwen He; Fotis Kolokathis; Luke Pater; Ioannis Paraskevaidis; W Keith Jones; Gerald W Dorn; Dimitrios Th Kremastinos; Evangelia G Kranias
A human phospholamban promoter polymorphism in dilated cardiomyopathy alters transcriptional regulation by glucocorticoids.
Human mutation 2008;29(5):640-7.
2008: Abhinav Diwan; Janaka Wansapura; Faisal M Syed; Scot J Matkovich; John N Lorenz; Gerald W Dorn
Nix-mediated apoptosis links myocardial fibrosis, cardiac remodeling, and hypertrophy decompensation.
Circulation 2008;117(3):396-404.
2008: Sharon L R Kardia; Reagan J Kelly; Mehdi A Keddache; Bruce Aronow; Gregory A Grabowski; Harvey S Hahn; Karen L Case; Lynne E Wagoner; Gerald W Dorn; Stephen B Liggett
Multiple interactions between the alpha 2C- and beta1-adrenergic receptors influence heart failure survival.
BMC medical genetics 2008;9():93.
2007: Stephen B Liggett; Reagan J Kelly; Rohan R Parekh; Scot J Matkovich; Bonnie J Benner; Harvey S Hahn; Faisal M Syed; Anita S Galvez; Karen L Case; Nancy McGuire; Amy Odley; Li Sparks; Sharon L R Kardia; Gerald W Dorn
A functional polymorphism of the Galphaq (GNAQ) gene is associated with accelerated mortality in African-American heart failure.
Human molecular genetics 2007;16(22):2740-50.
2007: Gerald W Dorn
Periostin and myocardial repair, regeneration, and recovery.
The New England journal of medicine 2007;357(15):1552-4.
2007: Abhinav Diwan; Maike Krenz; Faisal M Syed; Janaka Wansapura; Xiaoping Ren; Andrew G Koesters; Hairong Li; Lorrie A Kirshenbaum; Harvey S Hahn; Jeffrey Robbins; W Keith Jones; Gerald W Dorn
Inhibition of ischemic cardiomyocyte apoptosis through targeted ablation of Bnip3 restrains postinfarction remodeling in mice.
The Journal of clinical investigation 2007;117(10):2825-33.
2007: Toru Oka; Jian Xu; Robert A Kaiser; Jaime Melendez; Michael Hambleton; Michelle A Sargent; Angela Lorts; Eric W Brunskill; Gerald W Dorn; Simon J Conway; Bruce Aronow; Jeffrey Robbins; Jeffery D Molkentin
Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling.
Circulation research 2007;101(3):313-21.
2007: Tomoki Nakamura; Melissa C Colbert; Maike Krenz; Jeffery D Molkentin; Harvey S Hahn; Gerald W Dorn; Jeffrey Robbins
Mediating ERK 1/2 signaling rescues congenital heart defects in a mouse model of Noonan syndrome.
The Journal of clinical investigation 2007;117(8):2123-32.
2007: Gerald W Dorn
Myocardial angiogenesis: its absence makes the growing heart founder.
Cell metabolism 2007;5(5):326-7.
2007: Gerald W Dorn
The fuzzy logic of physiological cardiac hypertrophy.
Hypertension 2007;49(5):962-70.
2007: Abhinav Diwan; Andrew G Koesters; Amy Odley; Suvarnamala Pushkaran; Christopher P Baines; Benjamin T Spike; Diedre Daria; anil jegga; Hartmut Geiger; Bruce Aronow; Jeffery D Molkentin; Kay F Macleod; Theodosia A Kalfa; Gerald W Dorn
Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(16):6794-9.
2007: Anita S Galvez; Abhinav Diwan; Amy Odley; Harvey S Hahn; Hanna Osinska; Jaime G Melendez; Jeffrey Robbins; Roy A Lynch; Yehia Marreez; Gerald W Dorn
Cardiomyocyte degeneration with calpain deficiency reveals a critical role in protein homeostasis.
Circulation research 2007;100(7):1071-8.
2007: Abhinav Diwan; Gerald W Dorn
Decompensation of cardiac hypertrophy: cellular mechanisms and novel therapeutic targets.
Physiology (Bethesda, Md.) 2007;22():56-64.
2007: Qunying Yuan; Guo-Chang Fan; Min Dong; Beth Altschafl; Abhinav Diwan; Xiaoping Ren; Harvey H Hahn; Wen Zhao; Jason R Waggoner; Larry R Jones; W Keith Jones; Donald M Bers; Gerald W Dorn; Hong-Sheng Wang; Héctor H Valdivia; Guoxiang Chu; Evangelia G Kranias
Sarcoplasmic reticulum calcium overloading in junctin deficiency enhances cardiac contractility but increases ventricular automaticity.
Circulation 2007;115(3):300-9.
2007: Gerald W Dorn
The Gordon Wilson Lecture: neurohormonal signaling pathways that link cardiac growth and death.
Transactions of the American Clinical and Climatological Association 2007;118():137-52.
2006: Scot J Matkovich; Abhinav Diwan; Justin L Klanke; Daniel J Hammer; Yehia Marreez; Amy Odley; Eric W Brunskill; Walter J Koch; Robert J Schwartz; Gerald W Dorn
Cardiac-specific ablation of G-protein receptor kinase 2 redefines its roles in heart development and beta-adrenergic signaling.
Circulation research 2006;99(9):996-1003.
2006: Michael Hambleton; Harvey Hahn; Sven T Pleger; Matthew C Kuhn; Raisa Klevitsky; Andrew N Carr; Thomas F Kimball; Timothy E Hewett; Gerald W Dorn; Walter J Koch; Jeffery D Molkentin
Pharmacological- and gene therapy-based inhibition of protein kinase Calpha/beta enhances cardiac contractility and attenuates heart failure.
Circulation 2006;114(6):574-82.
2006: Kimberly N Gregory; Kenneth S Ginsburg; Ilona Bodi; Harvey Hahn; Yehia Marreez; Qiujing Song; Prabhu A Padmanabhan; Bryan Mitton; Jason R Waggoner; Federica del Monte; Woo Jin Park; Gerald W Dorn; Donald M Bers; Evangelia G Kranias
Histidine-rich Ca binding protein: a regulator of sarcoplasmic reticulum calcium sequestration and cardiac function.
Journal of molecular and cellular cardiology 2006;40(5):653-65.
2006: Wen Zhao; Qunying Yuan; Jiang Qian; Jason R Waggoner; Anand Pathak; Guoxiang Chu; Bryan Mitton; Xiaoyin Sun; Jay Jin; Julian C Braz; Harvey S Hahn; Yehia Marreez; Faisal M Syed; Piero Pollesello; Arto Annila; Hong-Sheng Wang; Jo El J Schultz; Jeffery D Molkentin; Stephen B Liggett; Gerald W Dorn; Evangelia G Kranias
The presence of Lys27 instead of Asn27 in human phospholamban promotes sarcoplasmic reticulum Ca2+-ATPase superinhibition and cardiac remodeling.
Circulation 2006;113(7):995-1004.
2006: Kobra Haghighi; Fotis Kolokathis; Anthony O Gramolini; Jason R Waggoner; Luke Pater; Roy A Lynch; Guo-Chang Fan; Dimitris Tsiapras; Rohan R Parekh; Gerald W Dorn; David H MacLennan; Dimitrios Th Kremastinos; Evangelia G Kranias
A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(5):1388-93.
2006: Anita S Gálvez; Eric W Brunskill; Yehia Marreez; Bonnie J Benner; Kelly M Regula; Lorrie A Kirschenbaum; Gerald W Dorn
Distinct pathways regulate proapoptotic Nix and BNip3 in cardiac stress.
The Journal of biological chemistry 2006;281(3):1442-8.
2005: Sakthivel Sadayappan; James Gulick; Hanna Osinska; Lisa A Martin; Harvey S Hahn; Gerald W Dorn; Raisa Klevitsky; Christine E Seidman; Jonathan G Seidman; Jeffrey Robbins
Cardiac myosin-binding protein-C phosphorylation and cardiac function.
Circulation research 2005;97(11):1156-63.
2005: Shigeki Miyamoto; Amy L Howes; John W Adams; Gerald W Dorn; Joan Heller Brown
Ca2+ dysregulation induces mitochondrial depolarization and apoptosis: role of Na+/Ca2+ exchanger and AKT.
The Journal of biological chemistry 2005;280(46):38505-12.
2005: Eric W Brunskill; Lisa A Ehrman; Michael T Williams; Justin Klanke; Daniel Hammer; Tori L Schaefer; Renu Sah; Gerald W Dorn; steven potter; Charles V Vorhees
Abnormal neurodevelopment, neurosignaling and behaviour in Npas3-deficient mice.
The European journal of neuroscience 2005;22(6):1265-76.
2005: Gerald W Dorn
Physiologic growth and pathologic genes in cardiac development and cardiomyopathy.
Trends in cardiovascular medicine 2005;15(5):185-9.
2005: Faisal M Syed; Harvey S Hahn; Amy Odley; Yiru Guo; Jesus G Vallejo; Roy A Lynch; Douglas L Mann; Roberto Bolli; Gerald W Dorn
Proapoptotic effects of caspase-1/interleukin-converting enzyme dominate in myocardial ischemia.
Circulation research 2005;96(10):1103-9.
2005: Christopher P Baines; Robert A Kaiser; Nicole H Purcell; N Scott Blair; Hanna Osinska; Michael Hambleton; Eric W Brunskill; M Richard Sayen; Roberta Anne Gottlieb; Gerald W Dorn; Jeffrey Robbins; Jeffery D Molkentin
Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death.
Nature 2005;434(7033):658-62.
2005: Gerald W Dorn; Thomas Force
Protein kinase cascades in the regulation of cardiac hypertrophy.
The Journal of clinical investigation 2005;115(3):527-37.
2004: Faisal M Syed; Amy Odley; Harvey S Hahn; Eric W Brunskill; Roy A Lynch; Yehia Marreez; Atsushi Sanbe; Jeffrey Robbins; Gerald W Dorn
Physiological growth synergizes with pathological genes in experimental cardiomyopathy.
Circulation research 2004;95(12):1200-6.
2004: Amy Odley; Harvey S Hahn; Roy A Lynch; Yehia Marreez; Hanna Osinska; Jeffrey Robbins; Gerald W Dorn
Regulation of cardiac contractility by Rab4-modulated beta2-adrenergic receptor recycling.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(18):7082-7.
2004: Gerald W Dorn; Harvey S Hahn
Genetic factors in cardiac hypertrophy.
Annals of the New York Academy of Sciences 2004;1015():225-37.
2004: Kimberly N Gregory; Harvey Hahn; Kobra Haghighi; Yehia Marreez; Amy Odley; Gerald W Dorn; Evangelia G Kranias
Increased particulate partitioning of PKC epsilon reverses susceptibility of phospholamban knockout hearts to ischemic injury.
Journal of molecular and cellular cardiology 2004;36(2):313-8.
2004: Gerald W Dorn; Jeffery D Molkentin
Manipulating cardiac contractility in heart failure: data from mice and men.
Circulation 2004;109(2):150-8.
2003: Harvey S Hahn; Yehia Marreez; Amy Odley; Amber Sterbling; Martin G Yussman; K Chad Hilty; Ilona Bodi; Stephen B Liggett; Arnold Schwartz; Gerald W Dorn
Protein kinase Calpha negatively regulates systolic and diastolic function in pathological hypertrophy.
Circulation research 2003;93(11):1111-9.
2003: Jeanne Mialet Perez; Deborah A Rathz; Natalia N Petrashevskaya; Harvey S Hahn; Lynne E Wagoner; Arnold Schwartz; Gerald W Dorn; Stephen B Liggett
Beta 1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure.
Nature medicine 2003;9(10):1300-5.
2003: Mohamad Azhar; Jo El J Schultz; Ingrid L Grupp; Gerald W Dorn; Pierre Meneton; Daniël G M Molin; Adriana C Gittenberger-De Groot; Thomas Doetschman
Transforming growth factor beta in cardiovascular development and function.
Cytokine & growth factor reviews 2003;14(5):391-407.
2003: Koichi Inagaki; Harvey S Hahn; Gerald W Dorn; Daria Mochly-Rosen
Additive protection of the ischemic heart ex vivo by combined treatment with delta-protein kinase C inhibitor and epsilon-protein kinase C activator.
Circulation 2003;108(7):869-75.
2003: Albrecht G Schmidt; Kobra Haghighi; Beate Frank; Luke Pater; Gerald W Dorn; Richard A Walsh; Evangelia G Kranias
Polymorphic SERCA2a variants do not account for inter-individual differences in phospholamban-SERCA2a interactions in human heart failure.
Journal of molecular and cellular cardiology 2003;35(7):867-70.
2003: Marina N Nikiforova; Roy A Lynch; Paul Williams Biddinger; Erik K Alexander; Gerald W Dorn; Giovanni Tallini; Todd G Kroll; Yuri E Nikiforov
RAS point mutations and PAX8-PPAR gamma rearrangement in thyroid tumors: evidence for distinct molecular pathways in thyroid follicular carcinoma.
The Journal of clinical endocrinology and metabolism 2003;88(5):2318-26.
2003: Kobra Haghighi; Fotis Kolokathis; Luke Pater; Roy A Lynch; Michio Asahi; Anthony O Gramolini; Guo-Chang Fan; Dimitris Tsiapras; Harvey S Hahn; Stamatis Adamopoulos; Stephen B Liggett; Gerald W Dorn; David H MacLennan; Dimitrios Th Kremastinos; Evangelia G Kranias
Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human.
The Journal of clinical investigation 2003;111(6):869-76.
2003: Qiujing Song; Albrecht G Schmidt; Harvey S Hahn; Andrew N Carr; Beate Frank; Luke Pater; Michael J Gerst; Karen Young; Brian D Hoit; Bradley K McConnell; Kobra Haghighi; Christine E Seidman; Jonathan G Seidman; Gerald W Dorn; Evangelia G Kranias
Rescue of cardiomyocyte dysfunction by phospholamban ablation does not prevent ventricular failure in genetic hypertrophy.
The Journal of clinical investigation 2003;111(6):859-67.
2002: Gerald W Dorn; Douglas L Mann
Signaling pathways involved in left ventricular remodeling: summation.
Journal of cardiac failure 2002;8(6 Suppl):S387-8.
2002: Gerald W Dorn
Adrenergic pathways and left ventricular remodeling.
Journal of cardiac failure 2002;8(6 Suppl):S370-3.
2002: Lynne E Wagoner; Laura L Craft; Paul Zengel; Nancy McGuire; Deborah A Rathz; Gerald W Dorn; Stephen B Liggett
Polymorphisms of the beta1-adrenergic receptor predict exercise capacity in heart failure.
American heart journal 2002;144(5):840-6.
2002: Harvey S Hahn; Martin G Yussman; Tsuyoshi Toyokawa; Yehia Marreez; Thomas J Barrett; K Chad Hilty; Hanna Osinska; Jeffrey Robbins; Gerald W Dorn
Ischemic protection and myofibrillar cardiomyopathy: dose-dependent effects of in vivo deltaPKC inhibition.
Circulation research 2002;91(8):741-8.
2002: Roy A Lynch; Lynne E Wagoner; Shunan Li; Li Sparks; Jeffery D Molkentin; Gerald W Dorn
Novel and nondetected human signaling protein polymorphisms.
Physiological genomics 2002;10(3):159-68.
2002: Martin G Yussman; Tsuyoshi Toyokawa; Amy Odley; Roy A Lynch; Guangyu Wu; Melissa C Colbert; Bruce Aronow; John N Lorenz; Gerald W Dorn
Mitochondrial death protein Nix is induced in cardiac hypertrophy and triggers apoptotic cardiomyopathy.
Nature medicine 2002;8(7):725-30.
2002: Gerald W Dorn; Daria Mochly-Rosen
Intracellular transport mechanisms of signal transducers.
Annual review of physiology 2002;64():407-29.
2001: Guangyu Wu; Martin G Yussman; T J Barrett; Harvey S Hahn; Hanna Osinska; George M Hilliard; Xinkang Wang; Tsuyoshi Toyokawa; Atsuko Yatani; Roy A Lynch; Jeffrey Robbins; Gerald W Dorn
Increased myocardial Rab GTPase expression: a consequence and cause of cardiomyopathy.
Circulation research 2001;89(12):1130-7.
2001: Leon Chen; Harvey Hahn; Guangyu Wu; CH Chen; Tamar Liron; Deborah Schechtman; G Cavallaro; L Banci; Y Guo; Roberto Bolli; Gerald W Dorn; Daria Mochly-Rosen
Opposing cardioprotective actions and parallel hypertrophic effects of delta PKC and epsilon PKC.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(20):11114-9.
2001: Kobra Haghighi; Albrecht G Schmidt; Brian D Hoit; Angela G Brittsan; Atsuko Yatani; J William Lester; Jing Zhai; Y Kimura; Gerald W Dorn; David H MacLennan; Evangelia G Kranias
Superinhibition of sarcoplasmic reticulum function by phospholamban induces cardiac contractile failure.
The Journal of biological chemistry 2001;276(26):24145-52.
2001: Bruce Aronow; Tsuyoshi Toyokawa; AM Canning; K Haghighi; U Delling; Evangelia G Kranias; J D Molkentin; Gerald W Dorn
Divergent transcriptional responses to independent genetic causes of cardiac hypertrophy.
Physiological genomics 2001;6(1):19-28.
2001: Xuejun Wang; Hanna Osinska; Gerald W Dorn; Michelle L Nieman; John N Lorenz; A Martin Gerdes; Sandra Witt; T Kimball; James Gulick; Jeffrey Robbins
Mouse model of desmin-related cardiomyopathy.
Circulation 2001;103(19):2402-7.
2001: Yoji Sato; Helen Kiriazis; Atsuko Yatani; Albrecht G Schmidt; Harvey Hahn; DG Ferguson; H Sako; S Mitarai; R Honda; L Mesnard-Rouiller; Konrad Frank; B Beyermann; Guangyu Wu; K Fujimori; Gerald W Dorn; Evangelia G Kranias
Rescue of contractile parameters and myocyte hypertrophy in calsequestrin overexpressing myocardium by phospholamban ablation.
The Journal of biological chemistry 2001;276(12):9392-9.
2001: Rajesh Dash; Vivek J Kadambi; Albrecht G Schmidt; NM Tepe; Danuta Biniakiewicz; Michael J Gerst; AM Canning; William T Abraham; Brian D Hoit; Stephen B Liggett; John N Lorenz; Gerald W Dorn; Evangelia G Kranias
Interactions between phospholamban and beta-adrenergic drive may lead to cardiomyopathy and early mortality.
Circulation 2001;103(6):889-96.
2000: Guangyu Wu; Tsuyoshi Toyokawa; Harvey Hahn; Gerald W Dorn
Epsilon protein kinase C in pathological myocardial hypertrophy. Analysis by combined transgenic expression of translocation modifiers and Galphaq.
The Journal of biological chemistry 2000;275(39):29927-30.
2000: Daria Mochly-Rosen; Guangyu Wu; Harvey Hahn; Hanna Osinska; Tamar Liron; John N Lorenz; Atsuko Yatani; J Robbins; Gerald W Dorn
Cardiotrophic effects of protein kinase C epsilon: analysis by in vivo modulation of PKCepsilon translocation.
Circulation research 2000;86(11):1173-9.
2000: Lynne E Wagoner; Laura L Craft; B Singh; Damodhar P Suresh; P W Zengel; Nancy McGuire; William T Abraham; T C Chenier; Gerald W Dorn; Stephen B Liggett
Polymorphisms of the beta(2)-adrenergic receptor determine exercise capacity in patients with heart failure.
Circulation research 2000;86(8):834-40.
2000: Stephen B Liggett; NM Tepe; John N Lorenz; AM Canning; T D Jantz; S Mitarai; Atsuko Yatani; Gerald W Dorn
Early and delayed consequences of beta(2)-adrenergic receptor overexpression in mouse hearts: critical role for expression level.
Circulation 2000;101(14):1707-14.
2000: Leon J De Windt; HW Lim; T Taigen; Detlef Wencker; G Condorelli; Gerald W Dorn; Richard N Kitsis; Jeffery D Molkentin
Calcineurin-mediated hypertrophy protects cardiomyocytes from apoptosis in vitro and in vivo: An apoptosis-independent model of dilated heart failure.
Circulation research 2000;86(3):255-63.
2000: Gerald W Dorn; NM Tepe; Guangyu Wu; Atsuko Yatani; Stephen B Liggett
Mechanisms of impaired beta-adrenergic receptor signaling in G(alphaq)-mediated cardiac hypertrophy and ventricular dysfunction.
Molecular pharmacology 2000;57(2):278-87.
1999: NM Tepe; John N Lorenz; Atsuko Yatani; Rajesh Dash; Evangelia G Kranias; Gerald W Dorn; Stephen B Liggett
Altering the receptor-effector ratio by transgenic overexpression of type V adenylyl cyclase: enhanced basal catalytic activity and function without increased cardiomyocyte beta-adrenergic signalling.
Biochemistry 1999;38(50):16706-13.
1999: Gerald W Dorn; M C Souroujon; Tamar Liron; CH Chen; Mary O Gray; Hui-Zhong Zhou; M Csukai; Guangyu Wu; John N Lorenz; Daria Mochly-Rosen
Sustained in vivo cardiac protection by a rationally designed peptide that causes epsilon protein kinase C translocation.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(22):12798-803.
1999: Kersten M Small; JF Feng; J Lorenz; E T Donnelly; A Yu; Mie-Jae Im; Gerald W Dorn; Stephen B Liggett
Cardiac specific overexpression of transglutaminase II (G(h)) results in a unique hypertrophy phenotype independent of phospholipase C activation.
The Journal of biological chemistry 1999;274(30):21291-6.
1999: Atsuko Yatani; Konrad Frank; H Sako; Evangelia G Kranias; Gerald W Dorn
Cardiac-specific overexpression of Galphaq alters excitation-contraction coupling in isolated cardiac myocytes.
Journal of molecular and cellular cardiology 1999;31(7):1327-36.
1999: Valerie P Sah; Susumu Minamisawa; S P Tam; T H Wu; Gerald W Dorn; John Ross; Kenneth R Chien; Joan Heller Brown
Cardiac-specific overexpression of RhoA results in sinus and atrioventricular nodal dysfunction and contractile failure.
The Journal of clinical investigation 1999;103(12):1627-34.
1999: Gerald W Dorn; NM Tepe; John N Lorenz; Walter J Koch; Stephen B Liggett
Low- and high-level transgenic expression of beta2-adrenergic receptors differentially affect cardiac hypertrophy and function in Galphaq-overexpressing mice.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(11):6400-5.
1999: Gerald W Dorn; J H Brown
Gq signaling in cardiac adaptation and maladaptation.
Trends in cardiovascular medicine 1999;9(1-2):26-34.
1998: Yoji Sato; DG Ferguson; H Sako; Gerald W Dorn; Vivek J Kadambi; Atsuko Yatani; Brian D Hoit; Richard A Walsh; Evangelia G Kranias
Cardiac-specific overexpression of mouse cardiac calsequestrin is associated with depressed cardiovascular function and hypertrophy in transgenic mice.
The Journal of biological chemistry 1998;273(43):28470-7.
1998: John W Adams; Y Sakata; MG Davis; Valerie P Sah; Yingxiao Wang; Stephen B Liggett; Kenneth R Chien; Joan Heller Brown; Gerald W Dorn
Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(17):10140-5.
1998: Mei Liang; Margaret G Eason; EA Jewell-Motz; M A Williams; Cheryl T Theiss; Gerald W Dorn; Stephen B Liggett
Phosphorylation and functional desensitization of the alpha2A-adrenergic receptor by protein kinase C.
Molecular pharmacology 1998;54(1):44-9.
1998: CM Pawloski-Dahm; G Song; D L Kirkpatrick; J Palermo; James Gulick; Gerald W Dorn; Jeffrey Robbins; Richard A Walsh
Effects of total replacement of atrial myosin light chain-2 with the ventricular isoform in atrial myocytes of transgenic mice.
Circulation 1998;97(15):1508-13.
1998: Y Sakata; Brian D Hoit; Stephen B Liggett; Richard A Walsh; Gerald W Dorn
Decompensation of pressure-overload hypertrophy in G alpha q-overexpressing mice.
Circulation 1998;97(15):1488-95.
1997: K Paul; NA Ball; Gerald W Dorn; Richard A Walsh
Left ventricular stretch stimulates angiotensin II--mediated phosphatidylinositol hydrolysis and protein kinase C epsilon isoform translocation in adult guinea pig hearts.
Circulation research 1997;81(5):643-50.
1997: Guoxiang Chu; Gerald W Dorn; W Luo; Judy M Harrer; Vivek J Kadambi; Richard A Walsh; Evangelia G Kranias
Monomeric phospholamban overexpression in transgenic mouse hearts.
Circulation research 1997;81(4):485-92.
1997: D D D'Angelo; Y Sakata; John N Lorenz; Gregory P Boivin; R A Walsh; Stephen B Liggett; Gerald W Dorn
Transgenic Galphaq overexpression induces cardiac contractile failure in mice.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(15):8121-6.
1997: J Qian; M Hendrix; W J Larsen; Gerald W Dorn; James L Lessard
Establishment and characterization of a conditionally immortalized smooth muscle/myometrial-like cell line.
Molecular reproduction and development 1997;47(3):284-94.
1997: Gerald W Dorn; K J Oswald; TS McCluskey; David G Kuhel; Stephen B Liggett
Alpha 2A-adrenergic receptor stimulated calcium release is transduced by Gi-associated G(beta gamma)-mediated activation of phospholipase C.
Biochemistry 1997;36(21):6415-23.
1997: Gerald W Dorn; MG Davis; D D D'Angelo
Structural determinants for agonist binding affinity to thromboxane/prostaglandin endoperoxide (TP) receptors. Analysis of chimeric rat/human TP receptors.
The Journal of biological chemistry 1997;272(19):12399-405.
1997: MG Davis; M Zhou; S Ali; J D Coffin; Thomas Doetschman; Gerald W Dorn
Intracrine and autocrine effects of basic fibroblast growth factor in vascular smooth muscle cells.
Journal of molecular and cellular cardiology 1997;29(4):1061-72.
1997: Gerald W Dorn
Role of thromboxane A2 in mitogenesis of vascular smooth muscle cells.
Agents and actions. Supplements 1997;48():42-62.
1996: D D D'Angelo; T Terasawa; S J Carlisle; Gerald W Dorn; K R Lynch
Characterization of a rat kidney thromboxane A2 receptor: high affinity for the agonist ligand I-BOP.
Prostaglandins 1996;52(4):303-16.
1996: D D D'Angelo; B G Oliver; M G Davis; TS McCluskey; Gerald W Dorn
Novel role for Sp1 in phorbol ester enhancement of human platelet thromboxane receptor gene expression.
The Journal of biological chemistry 1996;271(33):19696-704.
1996: J F Collins; CM Pawloski-Dahm; M G Davis; NA Ball; Gerald W Dorn; R A Walsh
The role of the cytoskeleton in left ventricular pressure overload hypertrophy and failure.
Journal of molecular and cellular cardiology 1996;28(7):1435-43.
1996: D D D'Angelo; J J Eubank; M G Davis; Gerald W Dorn
Mutagenic analysis of platelet thromboxane receptor cysteines. Roles in ligand binding and receptor-effector coupling.
The Journal of biological chemistry 1996;271(11):6233-40.
1996: A M Gunteski-Hamblin; G Song; R A Walsh; M Frenzke; Gregory P Boivin; Gerald W Dorn; Marcia A Kaetzel; Nelson D Horseman; John R Dedman
Annexin VI overexpression targeted to heart alters cardiomyocyte function in transgenic mice.
The American journal of physiology 1996;270(3 Pt 2):H1091-100.
1996: Vivek J Kadambi; S Ponniah; Judy M Harrer; Brian D Hoit; Gerald W Dorn; R A Walsh; Evangelia G Kranias
Cardiac-specific overexpression of phospholamban alters calcium kinetics and resultant cardiomyocyte mechanics in transgenic mice.
The Journal of clinical investigation 1996;97(2):533-9.
1995: J D Coffin; R Z Florkiewicz; J Neumann; T Mort-Hopkins; Gerald W Dorn; P Lightfoot; Rebecca German ; P N Howles; A Kier; B A O'Toole
Abnormal bone growth and selective translational regulation in basic fibroblast growth factor (FGF-2) transgenic mice.
Molecular biology of the cell 1995;6(12):1861-73.
1995: D D D'Angelo; M G Davis; W A Houser; J J Eubank; M E Ritchie; Gerald W Dorn
Characterization of 5' end of human thromboxane receptor gene. Organizational analysis and mapping of protein kinase C--responsive elements regulating expression in platelets.
Circulation research 1995;77(3):466-74.
1994: M G Davis; S Ali; George Leikauf; Gerald W Dorn
Tyrosine kinase inhibition prevents deformation-stimulated vascular smooth muscle growth.
Hypertension 1994;24(6):706-13.
1994: S Ali; Gerald W Dorn
Patterns of tyrosine phosphorylation differ in vascular hypertrophy and hyperplasia.
The American journal of physiology 1994;267(6 Pt 1):C1674-81.
1994: D D D'Angelo; M G Davis; S Ali; Gerald W Dorn
Cloning and pharmacologic characterization of a thromboxane A2 receptor from K562 (human chronic myelogenous leukemia) cells.
The Journal of pharmacology and experimental therapeutics 1994;271(2):1034-41.
1994: S Ali; M W Becker; M G Davis; Gerald W Dorn
Dissociation of vasoconstrictor-stimulated basic fibroblast growth factor expression from hypertrophic growth in cultured vascular smooth muscle cells. Relevant roles of protein kinase C.
Circulation research 1994;75(5):836-43.
1994: S P Williams; Gerald W Dorn; Robert M Rapoport
Prostaglandin I2 mediates contraction and relaxation of vascular smooth muscle.
The American journal of physiology 1994;267(2 Pt 2):H796-803.
1994: Gerald W Dorn; Jeffrey Robbins; NA Ball; R A Walsh
Myosin heavy chain regulation and myocyte contractile depression after LV hypertrophy in aortic-banded mice.
The American journal of physiology 1994;267(1 Pt 2):H400-5.
1994: Gerald W Dorn; M G Davis; D D D'Angelo
Gene expression during phorbol ester-induced differentiation of cultured human megakaryoblastic cells.
The American journal of physiology 1994;266(5 Pt 1):C1231-9.
1993: S Ali; M G Davis; M W Becker; Gerald W Dorn
Thromboxane A2 stimulates vascular smooth muscle hypertrophy by up-regulating the synthesis and release of endogenous basic fibroblast growth factor.
The Journal of biological chemistry 1993;268(23):17397-403.
1993: Gerald W Dorn; M W Becker
Thromboxane A2 stimulated signal transduction in vascular smooth muscle.
The Journal of pharmacology and experimental therapeutics 1993;265(1):447-56.
1992: Gerald W Dorn; M W Becker; M G Davis
Dissociation of the contractile and hypertrophic effects of vasoconstrictor prostanoids in vascular smooth muscle.
The Journal of biological chemistry 1992;267(34):24897-905.
1992: Gerald W Dorn; M G Davis
Differential megakaryocytic desensitization to platelet agonists.
The American journal of physiology 1992;263(4 Pt 1):C864-72.
1992: C L Jones; David P Witte; M J Feller; D A Fugman; Gerald W Dorn; M A Lieberman
Response of a human megakaryocytic cell line to thrombin: increase in intracellular free calcium and mitogen release.
Biochimica et biophysica acta 1992;1136(3):272-82.
1992: Gerald W Dorn; M G Davis
Thrombin, but not thromboxane, stimulates megakaryocytic differentiation in human megakaryoblastic leukemia cells.
The Journal of pharmacology and experimental therapeutics 1992;262(3):1242-7.
1992: Gerald W Dorn
Regulation of response to thromboxane A2 in CHRF-288 megakaryocytic cells.
The American journal of physiology 1992;262(4 Pt 1):C991-9.
1992: Gerald W Dorn; M W Becker
Growth factors downregulate vascular smooth muscle thromboxane receptors independent of cell growth.
The American journal of physiology 1992;262(4 Pt 1):C927-33.
1991: Gerald W Dorn
Mechanism for homologous downregulation of thromboxane A2 receptors in cultured human chronic myelogenous leukemia (K562) cells.
The Journal of pharmacology and experimental therapeutics 1991;259(1):228-34.
1991: Gerald W Dorn; A DeJesus
Human platelet aggregation and shape change are coupled to separate thromboxane A2-prostaglandin H2 receptors.
The American journal of physiology 1991;260(2 Pt 2):H327-34.