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Hirotoshi Dosaka-Akita

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Keidai Ishikawa; Tomoo Itoh; Masatoshi Kadoya; Kichizo Kaga; Mitsuhito Kaji; Tatsuya Kato; Li Li; Yoshiro Matsui; Yoshiyuki Matsumura; Roshan Mishra; Masaki Miyamoto; Toshiro Ohbuchi; Yasuhito Shoji; Tatsuya Yoshioka; Hirotoshi Dosaka-Akita; Yasuhiro Hida; Kazuomi Ichinokawa; Satoshi Hirano
Method for the validation of immunohistochemical staining using SCID mouse xenografts: expression of CD40 and CD154 in human non-small cell lung cancer.
Muhammad Baghdadi; Hirotoshi Dosaka-Akita; Hiroko Nagao; Hideo Yagita; Hironori Yoshiyama; Hisaya Akiba; Masahisa Jinushi
Combined blockade of TIM-3 and TIM-4 augments cancer vaccine efficacy against established melanomas.
Toshiyuki Harada; Fumihiro Hommura; Akira Inoue; Hiroshi Isobe; Kenichiro Ito; Yutaka Katsuura; Eiki Kikuchi; Ichiro Kinoshita; Tomoya Kuda; Makoto Maemondo; Masaharu Nishimura; Satoshi Oizumi; Shunichi Sugawara; Aya Suzuki; Kei Takamura; Hirotoshi Dosaka-Akita; Yuka Fujita
A Phase II Study of Amrubicin as a Third-Line or Fourth-Line Chemotherapy for Patients With Non-Small Cell Lung Cancer: Hokkaido Lung Cancer Clinical Study Group Trial (HOT) 0901.

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2013: Keidai Ishikawa; Tomoo Itoh; Masatoshi Kadoya; Kichizo Kaga; Mitsuhito Kaji; Tatsuya Kato; Li Li; Yoshiro Matsui; Yoshiyuki Matsumura; Roshan Mishra; Masaki Miyamoto; Toshiro Ohbuchi; Yasuhito Shoji; Tatsuya Yoshioka; Hirotoshi Dosaka-Akita; Yasuhiro Hida; Kazuomi Ichinokawa; Satoshi Hirano
Method for the validation of immunohistochemical staining using SCID mouse xenografts: expression of CD40 and CD154 in human non-small cell lung cancer.
Oncology reports 2013;29(4):1315-21.
2013: Muhammad Baghdadi; Hirotoshi Dosaka-Akita; Hiroko Nagao; Hideo Yagita; Hironori Yoshiyama; Hisaya Akiba; Masahisa Jinushi
Combined blockade of TIM-3 and TIM-4 augments cancer vaccine efficacy against established melanomas.
Cancer immunology, immunotherapy : CII 2013;62(4):629-37.
2013: Toshiyuki Harada; Fumihiro Hommura; Akira Inoue; Hiroshi Isobe; Kenichiro Ito; Yutaka Katsuura; Eiki Kikuchi; Ichiro Kinoshita; Tomoya Kuda; Makoto Maemondo; Masaharu Nishimura; Satoshi Oizumi; Shunichi Sugawara; Aya Suzuki; Kei Takamura; Hirotoshi Dosaka-Akita; Yuka Fujita
A Phase II Study of Amrubicin as a Third-Line or Fourth-Line Chemotherapy for Patients With Non-Small Cell Lung Cancer: Hokkaido Lung Cancer Clinical Study Group Trial (HOT) 0901.
The oncologist 2013;18(4):439-45.
2012: Junko Kikuchi; Ichiro Kinoshita; Victor E Marquez; Masaharu Nishimura; Satoshi Oizumi; Jun Sakakibara-Konishi; Yasushi Shimizu; Taichi Takashina; Eiki Kikuchi; Hirotoshi Dosaka-Akita
Epigenetic therapy with 3-deazaneplanocin A, an inhibitor of the histone methyltransferase EZH2, inhibits growth of non-small cell lung cancer cells.
Lung cancer (Amsterdam, Netherlands) 2012;78(2):138-43.
2012: Shigeki Chiba; John D Colgan; Hirotoshi Dosaka-Akita; Yoichiro Fujioka; Jacob V Gorman; Mitsuomi Hirashima; Ichiro Kinoshita; Yusuke Ohba; Akinori Takaoka; Toshimitsu Uede; Hideo Yagita; Hironori Yoshiyama; Hisaya Akiba; Muhammad Baghdadi; Masahisa Jinushi
Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1.
Nature immunology 2012;13(9):832-42.
2012: Kimitaka Tanaka; Takahiro Tsuchikawa; Hirotoshi Dosaka-Akita; Soldano Ferrone; Satoshi Hirano; Masaomi Ichinokawa; Kanako C Kubota; Takehiro Maki; Yoshihiro Matsuno; Masaki Miyamoto; Toshiaki Shichinohe; Satoshi Kondo
Down-regulation of Human Leukocyte Antigen class I heavy chain in tumors is associated with a poor prognosis in advanced esophageal cancer patients.
International journal of oncology 2012;40(4):965-74.
2012: Jun Sakakibara-Konishi; Satoshi Oizumi; Hirotoshi Dosaka-Akita; Eiki Kikuchi; Junko Kikuchi; Ichiro Kinoshita; Hidenori Mizugaki; Masaharu Nishimura
Expression of Bim, Noxa, and Puma in non-small cell lung cancer.
BMC cancer 2012;12():286.
2011: Jun Sakakibara-Konishi; Naofumi Shinagawa; Hiroki Shirato; Satoshi Oizumi; Rikiya Onimaru; Hirotoshi Dosaka-Akita; Tetsuya Inoue; Mototsugu Kato; Norio Katoh; Junko Kikuchi; Ichiro Kinoshita; Masaharu Nishimura
Phase I study of concurrent real-time tumor-tracking thoracic radiation therapy with paclitaxel and carboplatin in locally advanced non-small cell lung cancer.
Lung cancer (Amsterdam, Netherlands) 2011;74(2):248-52.
2011: Satoshi Takeuchi; Nagara Tamaki; Songji Zhao; Yan Zhao; Toshiyuki Hatano; Ichiro Kinoshita; Yuji Kuge; Ken-Ichi Nishijima; Yasushi Shimizu; Hirotoshi Dosaka-Akita
18F-fluorothymidine PET/CT as an early predictor of tumor response to treatment with cetuximab in human lung cancer xenografts.
Oncology reports 2011;26(3):725-30.
2011: Masahisa Jinushi; Ichiro Kinoshita; Kenkichi Masutomi; Shigeki Chiba; Hirotoshi Dosaka-Akita; Akinori Takaoka; Hideo Yagita; Hironori Yoshiyama; Hideaki Tahara
Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(30):12425-30.
2011: Satoshi Takeuchi; Toraji Amano; Rio Honma; Ichiro Kinoshita; Kanako Kubota; Yoshihiro Matsuno; Yasushi Shimizu; Jun Taguchi; Hirotoshi Dosaka-Akita
A Case of High-Grade Neuroendocrine Carcinoma That Improved with Bevacizumab plus Modified FOLFOX6 as the Fourth-Line Chemotherapy.
Case reports in oncology 2011;4(2):260-6.
2011: Junko Kikuchi; Ichiro Kinoshita; Yasushi Shimizu; Eiki Kikuchi; Kayoko Takeda; Hiroyuki Aburatani; Satoshi Oizumi; Jun Konishi; Kichizo Kaga; Yoshihiro Matsuno; Michael J Birrer; Masaharu Nishimura; Hirotoshi Dosaka-Akita
Minichromosome maintenance (MCM) protein 4 as a marker for proliferation and its clinical and clinicopathological significance in non-small cell lung cancer.
Lung cancer (Amsterdam, Netherlands) 2011;72(2):229-37.
2011: Kenji Akie; Hirotoshi Dosaka-Akita; Yuka Fujita; Shinichi Fukumoto; Masao Harada; Toshiyuki Harada; Hiroshi Isobe; Eiki Kikuchi; Ichiro Kinoshita; Tetsuya Kojima; Masaharu Nishimura; Shigeaki Ogura; Yoshinobu Ohsaki; Satoshi Oizumi; Naofumi Shinagawa
Phase II study of irinotecan plus S-1 combination for previously untreated advanced non-small cell lung cancer: Hokkaido Lung Cancer Clinical Study Group Trial (HOT) 0601.
Oncology 2011;81(2):84-90.
2011: Kenzo Hiroshima; Hirotoshi Dosaka-Akita; Katsuo Usuda; Shigeaki Ogura; Yoko Kusunoki; Tetsuro Kodama; Yasuki Saito; Masami Sato; Yutaka Tagawa; Masayuki Baba; Takashi Hirano; Takeshi Horai; Yoshihiro Matsuno
Cytological characteristics of pulmonary pleomorphic and giant cell carcinomas.
Acta cytologica 2011;55(2):173-9.
2011: Kayoko Takeda; Ichiro Kinoshita; Yasushi Shimizu; Yoshihiro Matsuno; Toshiaki Shichinohe; Hirotoshi Dosaka-Akita
Expression of LGR5, an intestinal stem cell marker, during each stage of colorectal tumorigenesis.
Anticancer research 2011;31(1):263-70.
2010: Junko Kikuchi; Ichiro Kinoshita; Yasushi Shimizu; Eiki Kikuchi; Jun Konishi; Satoshi Oizumi; Kichizo Kaga; Yoshihiro Matsuno; Masaharu Nishimura; Hirotoshi Dosaka-Akita
Distinctive expression of the polycomb group proteins Bmi1 polycomb ring finger oncogene and enhancer of zeste homolog 2 in nonsmall cell lung cancers and their clinical and clinicopathologic significance.
Cancer 2010;116(12):3015-24.
2010: Hajime Asahina; Satoshi Oizumi; Akira Inoue; Ichiro Kinoshita; Takashi Ishida; Yuka Fujita; Noriaki Sukoh; Masao Harada; Makoto Maemondo; Yasuo Saijo; Hirotoshi Dosaka-Akita; Hiroshi Isobe; Toshihiro Nukiwa; Masaharu Nishimura
Phase II study of gefitinib readministration in patients with advanced non-small cell lung cancer and previous response to gefitinib.
Oncology 2010;79(5-6):423-9.
2008: Keidai Ishikawa; Masaki Miyamoto; Tatsuya Yoshioka; Tatsuya Kato; Mitsuhito Kaji; Toshiro Ohbuchi; Satoshi Hirano; Tomoo Itoh; Hirotoshi Dosaka-Akita; Satoshi Kondo
Up-regulation of CD40 with juxtacrine activity in human nonsmall lung cancer cells correlates with poor prognosis.
Cancer 2008;113(3):530-41.
2008: Y Shimizu; I Kinoshita; J Kikuchi; K Yamazaki; Masaharu Nishimura; Michael J Birrer; Hirotoshi Dosaka-Akita
Growth inhibition of non-small cell lung cancer cells by AP-1 blockade using a cJun dominant-negative mutant.
British journal of cancer 2008;98(5):915-22.
2008: Mikado Imura; Koichi Yamazaki; Kanako C Kubota; Tomoo Itoh; Rikiya Onimaru; Yasushi Cho; Yasuhiro Hida; Kichizo Kaga; Yuya Onodera; Shigeaki Ogura; Hirotoshi Dosaka-Akita; Hiroki Shirato; Masaharu Nishimura
Histopathologic consideration of fiducial gold markers inserted for real-time tumor-tracking radiotherapy against lung cancer.
International journal of radiation oncology, biology, physics 2008;70(2):382-4.
2008: Kayoko Takeda; Ichiro Kinoshita; Yasushi Shimizu; Yusuke Ohba; Tomoo Itoh; Yoshihiro Matsuno; Toshiaki Shichinohe; Hirotoshi Dosaka-Akita
Clinicopathological significance of expression of p-c-Jun, TCF4 and beta-Catenin in colorectal tumors.
BMC cancer 2008;8():328.
2008: Eiki Kikuchi; Koichi Yamazaki; Eiichi Nakayama; Shuichiro Sato; Akiko Uenaka; Noriyuki Yamada; Satoshi Oizumi; Hirotoshi Dosaka-Akita; Masaharu Nishimura
Prolonged survival of patients with lung adenocarcinoma expressing XAGE-1b and HLA class I antigens.
Cancer immunity 2008;8():13.
2007: Eiki Kikuchi; Koichi Yamazaki; Toshihiko Torigoe; Yasushi Cho; Masaki Miyamoto; Satoshi Oizumi; Fumihiro Hommura; Hirotoshi Dosaka-Akita; Masaharu Nishimura
HLA class I antigen expression is associated with a favorable prognosis in early stage non-small cell lung cancer.
Cancer science 2007;98(9):1424-30.
2007: Nobuyuki Hakuma; Tomoko Betsuyaku; Ichiro Kinoshita; Tomoo Itoh; Kichizo Kaga; Satoshi Kondo; Masaharu Nishimura; Hirotoshi Dosaka-Akita
High incidence of extracellular matrix metalloproteinase inducer expression in non-small cell lung cancers. Association with clinicopathological parameters.
Oncology 2007;72(3-4):197-204.
2007: Hiroshi Yokouchi; Kenji Chamoto; Daiko Wakita; Koichi Yamazaki; Hiroki Shirato; Tsuguhide Takeshima; Hirotoshi Dosaka-Akita; Masaharu Nishimura; Zhang Yue; Hidemitsu Kitamura; Takashi Nishimura
Combination tumor immunotherapy with radiotherapy and Th1 cell therapy against murine lung carcinoma.
Clinical & experimental metastasis 2007;24(7):533-40.
2007: Hiroshi Yokouchi; Koichi Yamazaki; Ichiro Kinoshita; Jun Konishi; Hajime Asahina; Noriaki Sukoh; Masao Harada; Kenji Akie; Shigeaki Ogura; Takashi Ishida; Mitsuru Munakata; Hirotoshi Dosaka-Akita; Hiroshi Isobe; Masaharu Nishimura
Clinical benefit of readministration of gefitinib for initial gefitinib-responders with non-small cell lung cancer.
BMC cancer 2007;7():51.
2006: Hajime Asahina; Koichi Yamazaki; Ichiro Kinoshita; Hiroshi Yokouchi; Hirotoshi Dosaka-Akita; Masaharu Nishimura
Non-responsiveness to gefitinib in a patient with lung adenocarcinoma having rare EGFR mutations S768I and V769L.
Lung cancer (Amsterdam, Netherlands) 2006;54(3):419-22.
2006: Hajime Asahina; Koichi Yamazaki; Ichiro Kinoshita; Noriaki Sukoh; Masao Harada; Hiroshi Yokouchi; Takashi Ishida; Shigeaki Ogura; T Kojima; Y Okamoto; Y Fujita; Hirotoshi Dosaka-Akita; Hiroshi Isobe; Masaharu Nishimura
A phase II trial of gefitinib as first-line therapy for advanced non-small cell lung cancer with epidermal growth factor receptor mutations.
British journal of cancer 2006;95(8):998-1004.
2006: Megumi Nakadate; Koichi Yamazaki; Jun Konishi; Ichiro Kinoshita; Noriaki Sukoh; Masao Harada; Kenji Akie; Shigeaki Ogura; Takashi Ishida; Mitsuru Munakata; Hirotoshi Dosaka-Akita; Hiroshi Isobe; Masaharu Nishimura
Phase II study of carboplatin and weekly paclitaxel in advanced non-small cell lung cancer.
Anticancer research 2006;26(5B):3767-72.
2006: Hiroshi Yokouchi; Koichi Yamazaki; Hajime Asahina; Masahiko Shigemura; Takanori Moriyama; Kazuo Takaoka; Jun Moriya; Tomoo Itoh; Ichiro Kinoshita; Hirotoshi Dosaka-Akita; Yutaka Tsutsumi; Masaharu Nishimura
Establishment and characterization of amylase-producing lung adenocarcinoma cell line, IMEC-2.
Anticancer research 2006;26(4B):2821-7.
2006: Hiroshi Yokouchi; Kenji Chamoto; Daiko Wakita; Daisuke Noguchi; Koichi Yamazaki; Hirotoshi Dosaka-Akita; Masaharu Nishimura; Hiroaki Ikeda; Takashi Nishimura
Tetramer-blocking assay for defining antigen-specific cytotoxic T lymphocytes using peptide-MHC tetramer.
Cancer science 2006;97(2):148-54.
2005: Nobuyuki Hakuma; Ichiro Kinoshita; Yasushi Shimizu; Koichi Yamazaki; Koichi Yoshida; Masaharu Nishimura; Hirotoshi Dosaka-Akita
E1AF/PEA3 activates the Rho/Rho-associated kinase pathway to increase the malignancy potential of non-small-cell lung cancer cells.
Cancer research 2005;65(23):10776-82.
2005: Mikado Imura; Koichi Yamazaki; Hiroki Shirato; Rikiya Onimaru; Masaharu Fujino; Shinichi Shimizu; Toshiyuki Harada; Shigeaki Ogura; Hirotoshi Dosaka-Akita; Kazuo Miyasaka; Masaharu Nishimura
Insertion and fixation of fiducial markers for setup and tracking of lung tumors in radiotherapy.
International journal of radiation oncology, biology, physics 2005;63(5):1442-7.
2005: Rikiya Onimaru; Hiroki Shirato; Masaharu Fujino; Keishiro Suzuki; Kouichi Yamazaki; Masaharu Nishimura; Hirotoshi Dosaka-Akita; Kazuo Miyasaka
The effect of tumor location and respiratory function on tumor movement estimated by real-time tracking radiotherapy (RTRT) system.
International journal of radiation oncology, biology, physics 2005;63(1):164-9.
2005: Yoko Ishibashi; Koichiro Takeda; Noriyuki Tsukidate; Hiroki Miyazaki; Koji Ohira; Hirotoshi Dosaka-Akita; Masaharu Nishimura
Randomized placebo-controlled trial of interferon alpha-2b plus ribavirin with and without lactoferrin for chronic hepatitis C.
Hepatology research : the official journal of the Japan Society of Hepatology 2005;32(4):218-23.
2005: Mitsunori Kamigaki; Koichi Yamazaki; Ichizo Tsujino; Masayuki Suga; Shinji Sakaue; Hirotoshi Dosaka-Akita; Masaharu Nishimura
Small cell carcinoma of the lung exclusively localized within the left descending pulmonary artery.
Chest 2005;127(6):2273-6.
2005: Shin-ichi Fukumoto; Naoko Yamauchi; Hisashi Moriguchi; Yoshitaka Hippo; Akira Watanabe; Junji Shibahara; Hirokazu Taniguchi; Shumpei Ishikawa; Hirotaka Ito; Shogo Yamamoto; Hiroko Iwanari; Mitsugu Hironaka; Yuichi Ishikawa; Toshiro Niki; Yasunori Sohara; Tatsuhiko Kodama; Masaharu Nishimura; Masashi Fukayama; Hirotoshi Dosaka-Akita; Hiroyuki Aburatani
Overexpression of the aldo-keto reductase family protein AKR1B10 is highly correlated with smokers' non-small cell lung carcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(5):1776-85.
2005: Yoko Ishibashi; Hirotoshi Dosaka-Akita; Eiji Miyoshi; Masanobu Shindoh; Masaki Miyamoto; Ichiro Kinoshita; Hiroki Miyazaki; Tomoo Itoh; Satoshi Kondo; Masaharu Nishimura; Naoyuki Taniguchi
Expression of N-acetylglucosaminyltransferase V in the development of human esophageal cancers: immunohistochemical data from carcinomas and nearby noncancerous lesions.
Oncology 2005;69(4):301-10.
2005: Jun Konishi; Koichi Yamazaki; Ichiro Kinoshita; Hiroshi Isobe; Shigeaki Ogura; Satoko Sekine; Takashi Ishida; Riou Takashima; Megumi Nakadate; Shyu Nishikawa; Takeshi Hattori; Hajime Asahina; Mikado Imura; Eiki Kikuchi; Junko Kikuchi; Naofumi Shinagawa; Hiroshi Yokouchi; Mitsuru Munakata; Hirotoshi Dosaka-Akita; Masaharu Nishimura
Analysis of the response and toxicity to gefitinib of non-small cell lung cancer.
Anticancer research 2005;25(1B):435-41.
2004: Takayuki Yoshida; Toshiyuki Harada; Satoshi Fuke; Jun Konishi; Koichi Yamazaki; Mitsuhito Kaji; Toshiaki Morikawa; Satoshi Ota; Tomoo Itoh; Hirotoshi Dosaka-Akita; Masaharu Nishimura
Lung adenocarcinoma presenting with enlarged and multiloculated cystic lesions over 2 years.
Respiratory care 2004;49(12):1522-4.
2004: Masaki Fujieda; Hiroshi Yamazaki; Tetsuya Saito; Kazuma Kiyotani; Maxwell Afari Gyamfi; Masaharu Sakurai; Hirotoshi Dosaka-Akita; Yuichi Sawamura; Jun Yokota; Hideo Kunitoh; Tetsuya Kamataki
Evaluation of CYP2A6 genetic polymorphisms as determinants of smoking behavior and tobacco-related lung cancer risk in male Japanese smokers.
Carcinogenesis 2004;25(12):2451-8.
2004: Junko Kikuchi; Koichi Yamazaki; Ichiro Kinoshita; Hajime Asahina; Mikado Imura; Eiki Kikuchi; Jun Konishi; Naofumi Shinagawa; Hiromitsu Oki; Hirotoshi Dosaka-Akita; Masaharu Nishimura
Phase I trial of carboplatin and weekly paclitaxel in patients with advanced non-small-cell lung cancer.
Japanese journal of clinical oncology 2004;34(9):505-9.
2004: Jun Konishi; Koichi Yamazaki; Miyuki Azuma; Ichiro Kinoshita; Hirotoshi Dosaka-Akita; Masaharu Nishimura
B7-H1 expression on non-small cell lung cancer cells and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(15):5094-100.
2004: Jun Konishi; Koichi Yamazaki; Kanako Chikai; Kazuo Nagashima; Koichiro Sakai; Ichiro Kinoshita; Hirotoshi Dosaka-Akita; Masaharu Nishimura
Paraneoplastic cerebellar degeneration (PCD) associated with squamous cell carcinoma of the lung.
Internal medicine (Tokyo, Japan) 2004;43(7):602-6.
2004: Yuichi Nakamura; Koichi Yamazaki; Satoshi Oizumi; Manabu Nakashima; Takeshi Watanabe; Hirotoshi Dosaka-Akita; Masaharu Nishimura
Expression of RCAS1 in human gastric carcinoma: a potential mechanism of immune escape.
Cancer science 2004;95(3):260-5.
2004: Hirotoshi Dosaka-Akita; Eiji Miyoshi; Osamu Suzuki; Tomoo Itoh; Hiroyuki Katoh; Naoyuki Taniguchi
Expression of N-acetylglucosaminyltransferase v is associated with prognosis and histology in non-small cell lung cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(5):1773-9.
2004: Naofumi Shinagawa; Koichi Yamazaki; Yuya Onodera; Kazuo Miyasaka; Eiki Kikuchi; Hirotoshi Dosaka-Akita; Masaharu Nishimura
CT-guided transbronchial biopsy using an ultrathin bronchoscope with virtual bronchoscopic navigation.
Chest 2004;125(3):1138-43.
2003: Osamu Wakabayashi; Koichi Yamazaki; Satoshi Oizumi; Fumihiro Hommura; Ichiro Kinoshita; Shigeaki Ogura; Hirotoshi Dosaka-Akita; Masaharu Nishimura
CD4+ T cells in cancer stroma, not CD8+ T cells in cancer cell nests, are associated with favorable prognosis in human non-small cell lung cancers.
Cancer science 2003;94(11):1003-9.
2003: Jun Konishi; Koichi Yamazaki; Eriko Tsukamoto; Nagara Tamaki; Yuya Onodera; Toshiyuki Otake; Toshiaki Morikawa; Ichiro Kinoshita; Hirotoshi Dosaka-Akita; Masaharu Nishimura
Mediastinal lymph node staging by FDG-PET in patients with non-small cell lung cancer: analysis of false-positive FDG-PET findings.
Respiration; international review of thoracic diseases 2003;70(5):500-6.
2003: Tetsuya Kojima; Koichi Yamazaki; Yasuaki Tamura; Shigeaki Ogura; Kenzaburo Tani; Jun Konishi; Naofumi Shinagawa; Ichiro Kinoshita; Nobuyuki Hizawa; Etsuro Yamaguchi; Hirotoshi Dosaka-Akita; Masaharu Nishimura
Granulocyte-macrophage colony-stimulating factor gene-transduced tumor cells combined with tumor-derived gp96 inhibit tumor growth in mice.
Human gene therapy 2003;14(8):715-28.
2003: Hiroki Shirato; Toshiyuki Harada; Toru Harabayashi; Kazutoshi Hida; Hideho Endo; Kei Kitamura; Rikiya Onimaru; Koichi Yamazaki; Nobuaki Kurauchi; Tadashi Shimizu; Nobuo Shinohara; Michiaki Matsushita; Hirotoshi Dosaka-Akita; Kazuo Miyasaka
Feasibility of insertion/implantation of 2.0-mm-diameter gold internal fiducial markers for precise setup and real-time tumor tracking in radiotherapy.
International journal of radiation oncology, biology, physics 2003;56(1):240-7.
2003: Rikiya Onimaru; Hiroki Shirato; Shinichi Shimizu; Kei Kitamura; Bo Xu; Shin-ichi Fukumoto; Ta-Chen Chang; Katsuhisa Fujita; Masataka Oita; Kazuo Miyasaka; Masaharu Nishimura; Hirotoshi Dosaka-Akita
Tolerance of organs at risk in small-volume, hypofractionated, image-guided radiotherapy for primary and metastatic lung cancers.
International journal of radiation oncology, biology, physics 2003;56(1):126-35.
2003: Toshiyuki Harada; Shigeaki Ogura; Koichi Yamazaki; Ichiro Kinoshita; Tomoo Itoh; Hiroshi Isobe; Katsushige Yamashiro; Hirotoshi Dosaka-Akita; Masaharu Nishimura
Predictive value of expression of P53, Bcl-2 and lung resistance-related protein for response to chemotherapy in non-small cell lung cancers.
Cancer science 2003;94(4):394-9.
2003: Kaori Watanabe; Yasushi Shimizu; Satoshi Oizumi; Naofumi Shinagawa; Ichiro Kinoshita; Koichi Yamazaki; Yuya Onodera; Hiroshi Saito; Etsuro Yamaguchi; Hirotoshi Dosaka-Akita; Masaharu Nishimura
[A case of Mycobacterium avium pulmonary disease detected as multiple small nodular shadows and diagnosed by CT guided transbronchial biopsy with ultrathin bronchoscopy].
Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society 2003;41(2):107-11.
2003: Masaki Fujieda; Hiroshi Yamazaki; Kazuma Kiyotani; Asami Muroi; Hideo Kunitoh; Hirotoshi Dosaka-Akita; Yuichi Sawamura; Tetsuya Kamataki
Eighteen novel polymorphisms of the CYP2A13 gene in Japanese.
Drug metabolism and pharmacokinetics 2003;18(1):86-90.
2002: Satoshi Oizumi; Hiroshi Isobe; Shigeaki Ogura; Takashi Ishida; Koichi Yamazaki; Masaharu Nishimura; Yoshikazu Kawakami; Hirotoshi Dosaka-Akita
Topoisomerase inhibitor-induced apoptosis accompanied by down-regulation of Bcl-2 in human lung cancer cells.
Anticancer research 2002;22(6C):4029-37.
2002: Toshiyuki Harada; Hiroki Shirato; Shigeaki Ogura; Satoshi Oizumi; Koichi Yamazaki; Shinichi Shimizu; Rikiya Onimaru; Kazuo Miyasaka; Masaharu Nishimura; Hirotoshi Dosaka-Akita
Real-time tumor-tracking radiation therapy for lung carcinoma by the aid of insertion of a gold marker using bronchofiberscopy.
Cancer 2002;95(8):1720-7.
2002: Shin-Ichi Fukumoto; Hiroki Shirato; Shinichi Shimzu; Shigeaki Ogura; Rikiya Onimaru; Kei Kitamura; Koichi Yamazaki; Kazuo Miyasaka; Masaharu Nishimura; Hirotoshi Dosaka-Akita
Small-volume image-guided radiotherapy using hypofractionated, coplanar, and noncoplanar multiple fields for patients with inoperable Stage I nonsmall cell lung carcinomas.
Cancer 2002;95(7):1546-53.
2002: Hirotoshi Dosaka-Akita; I Kinoshita; K Yamazaki; H Izumi; T Itoh; H Katoh; Masaharu Nishimura; K Matsuo; Y Yamada; K Kohno
N-acetylgalactosaminyl transferase-3 is a potential new marker for non-small cell lung cancers.
British journal of cancer 2002;87(7):751-5.
2002: Noritaka Ariyoshi; Masami Miyamoto; Yuri Umetsu; Hideo Kunitoh; Hirotoshi Dosaka-Akita; Yu-Ichi Sawamura; Jun Yokota; Nobuo Nemoto; Kunio Sato; Tetsuya Kamataki
Genetic polymorphism of CYP2A6 gene and tobacco-induced lung cancer risk in male smokers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2002;11(9):890-4.
2002: Toru Takahashi; Mitsuru Munakata; Yoshinori Ohtsuka; Hiroshi Nisihara; Yasuyuki Nasuhara; Atsuko Kamachi-Satoh; Hirotoshi Dosaka-Akita; Yukihiko Homma; Yoshikazu Kawakami
Expression and alteration of ras and p53 proteins in patients with lung carcinoma accompanied by idiopathic pulmonary fibrosis.
Cancer 2002;95(3):624-33.
2002: Masato Takimoto; Gang Wei; Hirotoshi Dosaka-Akita; PZ Mao; S Kondo; Noriaki Sakuragi; I Chiba; T Miura; N Itoh; T Sasao; Richard C Koya; T Tsukamoto; S Fujimoto; H Katoh; Noboru Kuzumaki
Frequent expression of new cancer/testis gene D40/AF15q14 in lung cancers of smokers.
British journal of cancer 2002;86(11):1757-62.
2002: Koichi Yamazaki; Yasushi Furuta; Katsuji Marukawa; Jun Moriya; Mikio Shimizu; Mikio Arakawa; Tomoo Itoh; Michio Shimizu; Shinichi Fukumoto; Shigeaki Ogura; Hirotoshi Dosaka-Akita; Masaharu Nishimura
Inverted papilloma of the nasal cavity presenting with massive amounts of squamous metaplastic cells in sputum. A case report.
Acta cytologica 2002;46(3):596-600.
2002: Fumihiro Hommura; Keiji Furuuchi; Koichi Yamazaki; Shigeaki Ogura; Ichiro Kinoshita; Michio Shimizu; Tetsuya Moriuchi; Hiroyuki Katoh; Masaharu Nishimura; Hirotoshi Dosaka-Akita
Increased expression of beta-catenin predicts better prognosis in nonsmall cell lung carcinomas.
Cancer 2002;94(3):752-8.
2002: Satoshi Oizumi; Koichi Yamazaki; Manabu Nakashima; Takeshi Watanabe; Fumihiro Hommura; Shigeaki Ogura; Masaharu Nishimura; Hirotoshi Dosaka-Akita
RCAS1 expression: a potential prognostic marker for adenocarcinomas of the lung.
Oncology 2002;62(4):333-9.
2001: Manabu Masutani; J Suzuki; T Matsuda; A Dochin; K Sadaoka; A Nomura; Koji Ohira; K Takahashi; K Yamazaki; Hirotoshi Dosaka-Akita; Masaharu Nishimura; Yoshikazu Kawakami
Increased apoptosis associated with depressed type of early intestinal gastric cancer.
Japanese journal of cancer research : Gann 2001;92(11):1214-9.
2001: H Hiroumi; Hirotoshi Dosaka-Akita; K Yoshida; M Shindoh; T Ohbuchi; K Fujinaga; Masaharu Nishimura
Expression of E1AF/PEA3, an Ets-related transcription factor in human non-small-cell lung cancers: its relevance in cell motility and invasion.
International journal of cancer. Journal international du cancer 2001;93(6):786-91.
2001: Hirotoshi Dosaka-Akita; Fumihiro Hommura; T Mishina; Shigeaki Ogura; Michio Shimizu; Hiroyuki Katoh; Yoshikazu Kawakami
A risk-stratification model of non-small cell lung cancers using cyclin E, Ki-67, and ras p21: different roles of G1 cyclins in cell proliferation and prognosis.
Cancer research 2001;61(6):2500-4.
2001: Satoshi Oizumi; Yujiro Kon; Takashi Ishida; Koichi Yamazaki; Tomoo Itoh; Shigeaki Ogura; Hirotoshi Dosaka-Akita; Toshiaki Morikawa; Michio Shimizu; H Katoh; Yoshikazu Kawakami
A rare case of bronchial glomus tumor.
Respiration; international review of thoracic diseases 2001;68(1):95-8.
2000: Fumihiro Hommura; Hirotoshi Dosaka-Akita; T Mishina; M Nishi; T Kojima; H Hiroumi; Shigeaki Ogura; Michio Shimizu; Hiroyuki Katoh; Yoshikazu Kawakami
Prognostic significance of p27KIP1 protein and ki-67 growth fraction in non-small cell lung cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(10):4073-81.
2000: Hiroki Shirato; Shinichi Shimizu; Kei Kitamura; Takeshi Nishioka; Kenji Kagei; S Hashimoto; Hidefumi Aoyama; T Kunieda; Nobuo Shinohara; Hirotoshi Dosaka-Akita; Kazuo Miyasaka
Four-dimensional treatment planning and fluoroscopic real-time tumor tracking radiotherapy for moving tumor.
International journal of radiation oncology, biology, physics 2000;48(2):435-42.
2000: M Katabami; Hirotoshi Dosaka-Akita; T Mishina; K Honma; K Kimura; Y Uchida; K Morikawa; H Mikami; S Fukuda; Y Inuyama; Y Ohsaki; Y Kawakami
Frequent cyclin D1 expression in chromate-induced lung cancers.
Human pathology 2000;31(8):973-9.
2000: Kenji Akie; Hirotoshi Dosaka-Akita; A Murakami; Y Kawakami
A combination treatment of c-myc antisense DNA with all-trans-retinoic acid inhibits cell proliferation by downregulating c-myc expression in small cell lung cancer.
Antisense & nucleic acid drug development 2000;10(4):243-9.
2000: A Kamimura; M Kamachi; Jun Nishihira; Shigeaki Ogura; Hiroshi Isobe; Hirotoshi Dosaka-Akita; A Ogata; M Shindoh; T Ohbuchi; Yoshikazu Kawakami
Intracellular distribution of macrophage migration inhibitory factor predicts the prognosis of patients with adenocarcinoma of the lung.
Cancer 2000;89(2):334-41.
2000: M Katabami; Hirotoshi Dosaka-Akita; K Honma; Y Saitoh; K Kimura; Y Uchida; H Mikami; Y Ohsaki; Y Kawakami; K Kikuchi
Pneumoconiosis-related lung cancers: preferential occurrence from diffuse interstitial fibrosis-type pneumoconiosis.
American journal of respiratory and critical care medicine 2000;162(1):295-300.
2000: Shinichi Shimizu; Hiroki Shirato; Kenji Kagei; Takeshi Nishioka; X Bo; Hirotoshi Dosaka-Akita; S Hashimoto; Hidefumi Aoyama; Kazuhiko Tsuchiya; Kazuo Miyasaka
Impact of respiratory movement on the computed tomographic images of small lung tumors in three-dimensional (3D) radiotherapy.
International journal of radiation oncology, biology, physics 2000;46(5):1127-33.
2000: Hirotoshi Dosaka-Akita; Philip T Cagle; H Hiroumi; M Fujita; M Yamashita; A Sharma; Yoshikazu Kawakami; William F Benedict
Differential retinoblastoma and p16(INK4A) protein expression in neuroendocrine tumors of the lung.
Cancer 2000;88(3):550-6.
2000: T Mishina; Hirotoshi Dosaka-Akita; Fumihiro Hommura; M Nishi; T Kojima; Shigeaki Ogura; Michio Shimizu; Hiroyuki Katoh; Yoshikazu Kawakami
Cyclin E expression, a potential prognostic marker for non-small cell lung cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(1):11-6.
1999: Fumihiro Hommura; Hirotoshi Dosaka-Akita; Ichiro Kinoshita; T Mishina; H Hiroumi; Shigeaki Ogura; Hiroyuki Katoh; Yoshikazu Kawakami
Predictive value of expression of p16INK4A, retinoblastoma and p53 proteins for the prognosis of non-small-cell lung cancers.
British journal of cancer 1999;81(4):696-701.
1999: T Mishina; Hirotoshi Dosaka-Akita; Ichiro Kinoshita; Fumihiro Hommura; T Morikawa; Hiroyuki Katoh; Yoshikazu Kawakami
Cyclin D1 expression in non-small-cell lung cancers: its association with altered p53 expression, cell proliferation and clinical outcome.
British journal of cancer 1999;80(8):1289-95.
1999: Hirotoshi Dosaka-Akita; M Katabami; H Hommura; Y Fujioka; H Katoh; Y Kawakami
Bcl-2 expression in non-small cell lung cancers: higher frequency of expression in squamous cell carcinomas with earlier pT status.
Oncology 1999;56(3):259-64.
1998: M Katabami; Hirotoshi Dosaka-Akita; K Honma; K Kimura; M Fujino; Y Uchida; H Mikami; Y Ohsaki; Y Kawakami; K Kikuchi
p53 and Bcl-2 expression in pneumoconiosis-related pre-cancerous lesions and lung cancers: frequent and preferential p53 expression in pneumoconiotic bronchiolar dysplasias.
International journal of cancer. Journal international du cancer 1998;75(4):504-11.
1998: Hirotoshi Dosaka-Akita; Fumihiro Hommura; H Fujita; Ichiro Kinoshita; M Nishi; T Morikawa; Hiroyuki Katoh; Yoshikazu Kawakami; Noboru Kuzumaki
Frequent loss of gelsolin expression in non-small cell lung cancers of heavy smokers.
Cancer research 1998;58(2):322-7.
1997: A Ishikuro; Hirotoshi Dosaka-Akita; M Kato; M Fujino; Hiroshi Isobe; H Miyamoto; K Inoue; Y Kawakami
Ki-67 labeling indices in non-small cell lung cancer: comparison between image cytometry and flow cytometry.
Cytometry 1997;30(4):186-91.
1997: Hirotoshi Dosaka-Akita; Shi-Xue Hu; M Fujino; M Harada; Ichiro Kinoshita; H J Xu; Noboru Kuzumaki; Yoshikazu Kawakami; William F Benedict
Altered retinoblastoma protein expression in nonsmall cell lung cancer: its synergistic effects with altered ras and p53 protein status on prognosis.
Cancer 1997;79(7):1329-37.
1996: Ichiro Kinoshita; Hirotoshi Dosaka-Akita; T Mishina; K Akie; M Nishi; H Hiroumi; Fumihiro Hommura; Yoshikazu Kawakami
Altered p16INK4 and retinoblastoma protein status in non-small cell lung cancer: potential synergistic effect with altered p53 protein on proliferative activity.
Cancer research 1996;56(24):5557-62.
1996: T Hanada; S Ogura; H Isobe; Hirotoshi Dosaka-Akita; K Yamazaki; N Watanabe; Yoshikazu Kawakami
"Web-like obstruction"--a sign of regional complete remission after concurrent chemoradiotherapy in small cell lung cancer.
Internal medicine (Tokyo, Japan) 1996;35(9):732-5.
1995: M Fujino; Hirotoshi Dosaka-Akita; M Harada; H Hiroumi; Ichiro Kinoshita; K Akie; Yoshikazu Kawakami
Prognostic significance of p53 and ras p21 expression in nonsmall cell lung cancer.
Cancer 1995;76(12):2457-63.
1995: M Fujino; Hirotoshi Dosaka-Akita; M Kato; Ichiro Kinoshita; K Akie; Yoshikazu Kawakami
Simultaneous use of the PCR-SSCP method and immunohistochemistry for increasing the detection efficacy of p53 abnormalities in human lung cancer.
American journal of clinical pathology 1995;104(3):319-24.
1995: Hirotoshi Dosaka-Akita; K Akie; H Hiroumi; Ichiro Kinoshita; Yoshikazu Kawakami; A Murakami
Inhibition of proliferation by L-myc antisense DNA for the translational initiation site in human small cell lung cancer.
Cancer research 1995;55(7):1559-64.
1995: Ichiro Kinoshita; Hirotoshi Dosaka-Akita; M Shindoh; M Fujino; K Akie; M Kato; K Fujinaga; Yoshikazu Kawakami
Human papillomavirus type 18 DNA and E6-E7 mRNA are detected in squamous cell carcinoma and adenocarcinoma of the lung.
British journal of cancer 1995;71(2):344-9.
1994: Hirotoshi Dosaka-Akita; M Shindoh; M Fujino; Ichiro Kinoshita; K Akie; M Katoh; Yoshikazu Kawakami
Abnormal p53 expression in human lung cancer is associated with histologic subtypes and patient smoking history.
American journal of clinical pathology 1994;102(5):660-4.
1992: Hirotoshi Dosaka-Akita; M Harada; H Miyamoto; Yoshikazu Kawakami
[Clinical significance of oncogene product expression in human lung cancer].
Nihon Kyōbu Shikkan Gakkai zasshi 1992;30(8):1441-7.
1992: M Harada; Hirotoshi Dosaka-Akita; H Miyamoto; Noboru Kuzumaki; Yoshikazu Kawakami
Prognostic significance of the expression of ras oncogene product in non-small cell lung cancer.
Cancer 1992;69(1):72-7.