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Hinrich Abken

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Andreas Hombach; Gunter Rappl; Markus Chmielewski; Hinrich Abken
Adoptive immunotherapy with redirected T cells produces CCR7- cells that are trapped in the periphery and benefit from combined CD28-OX40 costimulation.
M Chmielewski; Andreas Hombach; Gunter Rappl; Hinrich Abken
T cells redirected by a CD3ζ chimeric antigen receptor can establish self-antigen-specific tumour protection in the long term.
Julia Etich; Christian Frie; Sandra Kreft; Frances E Lund; Cornelia Mauch; Mats Paulsson; Gunter Rappl; Hikmet Ulus; Hinrich Abken; Lena Bengestrate; Vera Bergmeier; Beate Eckes; Sabine A Eming; Bent Brachvogel
PECAM1(+)/Sca1(+)/CD38(+) vascular cells transform into myofibroblast-like cells in skin wound repair.

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2013: Andreas Hombach; Gunter Rappl; Markus Chmielewski; Hinrich Abken
Adoptive immunotherapy with redirected T cells produces CCR7- cells that are trapped in the periphery and benefit from combined CD28-OX40 costimulation.
Human gene therapy 2013;24(3):259-69.
2013: M Chmielewski; Andreas Hombach; Gunter Rappl; Hinrich Abken
T cells redirected by a CD3ζ chimeric antigen receptor can establish self-antigen-specific tumour protection in the long term.
Gene therapy 2013;20(2):177-86.
2013: Julia Etich; Christian Frie; Sandra Kreft; Frances E Lund; Cornelia Mauch; Mats Paulsson; Gunter Rappl; Hikmet Ulus; Hinrich Abken; Lena Bengestrate; Vera Bergmeier; Beate Eckes; Sabine A Eming; Bent Brachvogel
PECAM1(+)/Sca1(+)/CD38(+) vascular cells transform into myofibroblast-like cells in skin wound repair.
PloS one 2013;8(1):e53262.
2013: Tobias Riet; Niels Schaft; Gerold Schuler; Jan Dörrie; Astrid Holzinger; Hinrich Abken
Nonviral RNA transfection to transiently modify T cells with chimeric antigen receptors for adoptive therapy.
Methods in molecular biology (Clifton, N.J.) 2013;969():187-201.
2012: Amit Maliar; Charlotte Servais; Tova Waks; Ron Lavy; Hinrich Abken; Peter Altevogt; Markus Chmielewski; Zelig Eshhar
Redirected T cells that target pancreatic adenocarcinoma antigens eliminate tumors and metastases in mice.
Gastroenterology 2012;143(5):1375-84.e1-5.
2012: Ivan Grskovic; Anna Kutsch; Stephen E Moss; Anja Niehoff; Mats Paulsson; Ernst Pöschl; Gunter Rappl; Sabrina Rosenbaum; Ursula Schlötzer-Schrehardt; Jacek Stermann; Kathryn Se Cheah; Markus Chmielewski; Christian Frie; Gergely Groma; Hinrich Abken; John F Bateman; Bent Brachvogel
Depletion of annexin A5, annexin A6, and collagen X causes no gross changes in matrix vesicle-mediated mineralization, but lack of collagen X affects hematopoiesis and the Th1/Th2 response.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2012;27(11):2399-412.
2012: Markus Chmielewski; Olga Hahn; Andreas A Hombach; Michael Nowak; Gunter Rappl; Ingo H Schmidt-Wolf; Hinrich Abken
T cells that target carcinoembryonic antigen eradicate orthotopic pancreatic carcinomas without inducing autoimmune colitis in mice.
Gastroenterology 2012;143(4):1095-107.e2.
2012: Markus Chmielewski; Hinrich Abken
CAR T cells transform to trucks: chimeric antigen receptor-redirected T cells engineered to deliver inducible IL-12 modulate the tumour stroma to combat cancer.
Cancer immunology, immunotherapy : CII 2012;61(8):1269-77.
2012: David Gilham; Robert E Hawkins; Martin Pule; Reno Debets; Hinrich Abken
CAR-T cells and solid tumors: tuning T cells to challenge an inveterate foe.
Trends in molecular medicine 2012;18(7):377-84.
2012: Tobias Jahn; Martin Zuther; Hinrich Abken; Björn Friedrichs; Stefan Guhlke; Claudia Heuser; Andreas Hombach
An IL12-IL2-antibody fusion protein targeting Hodgkin's lymphoma cells potentiates activation of NK and T cells for an anti-tumor attack.
PloS one 2012;7(9):e44482.
2012: Eleanor J Cheadle; Markus Chmielewski; Reno Debets; Andreas A Hombach; Cor Lamers; Tobias Riet; Erik Schooten; Vicky Sheard; Hinrich Abken; Cor Berrevoets; David Gilham
Chimeric antigen receptors for T-cell based therapy.
Methods in molecular biology (Clifton, N.J.) 2012;907():645-66.
2012: Andreas A Hombach; Hinrich Abken
Antibody-IL2 fusion proteins for tumor targeting.
Methods in molecular biology (Clifton, N.J.) 2012;907():611-26.
2012: Rudolf Lichtenfels; Gunter Rappl; Christian V Recktenwald; Hinrich Abken; Sven P Dressler; Andreas Hombach; Barbara Seliger
A proteomic view at T cell costimulation.
PloS one 2012;7(4):e32994.
2012: Claudia Schlimper; Hinrich Abken; Andreas A Hombach; Ingo G H Schmidt-Wolf
Improved activation toward primary colorectal cancer cells by antigen-specific targeting autologous cytokine-induced killer cells.
Clinical & developmental immunology 2012;2012():238924.
2012: Manfred Lehner; Yves A Muller; ORNELLA PAROLINI; Julia Proff; Niels Schaft; Heinrich Kovar; Hinrich Abken; Peter F Ambros; Adelheid Cerwenka; Jan Dörrie; Armin Ensser; Florian Full; Gabriel Götz; Wolfgang Holter
Redirecting T cells to Ewing's sarcoma family of tumors by a chimeric NKG2D receptor expressed by lentiviral transduction or mRNA transfection.
PloS one 2012;7(2):e31210.
2012: Gunter Rappl; Tobias Riet; Annette Schmidt; Sabine Awerkiew; Andreas Hombach; Herbert Pfister; Hinrich Abken
The CD3-zeta chimeric antigen receptor overcomes TCR Hypo-responsiveness of human terminal late-stage T cells.
PloS one 2012;7(1):e30713.
2012: Max Schlaak; Patrick Schmidt; Christopher Bangard; Peter Kurschat; Cornelia Mauch; Hinrich Abken
Regression of metastatic melanoma in a patient by antibody targeting of cancer stem cells.
Oncotarget 2012;3(1):22-30.
2012: Philipp Koehler; Patrick Schmidt; Michael Hallek; Andreas A Hombach; Hinrich Abken
Engineered T cells for the adoptive therapy of B-cell chronic lymphocytic leukaemia.
Advances in hematology 2012;2012():595060.
2011: Andreas A Hombach; Hinrich Abken
Costimulation by chimeric antigen receptors revisited the T cell antitumor response benefits from combined CD28-OX40 signalling.
International journal of cancer. Journal international du cancer 2011;129(12):2935-44.
2011: Markus Chmielewski; Andreas Hombach; Caroline Kopecky; Hinrich Abken
IL-12 release by engineered T cells expressing chimeric antigen receptors can effectively Muster an antigen-independent macrophage response on tumor cells that have shut down tumor antigen expression.
Cancer research 2011;71(17):5697-706.
2011: Sharmilan Thanendrarajan; Hinrich Abken; Michael Nowak; Ingo G H Schmidt-Wolf
Combining cytokine-induced killer cells with vaccination in cancer immunotherapy: more than one plus one?
Leukemia research 2011;35(9):1136-42.
2011: Gunter Rappl; Dagmar Riemann; Annette Schmidt; Wolfgang Schütte; Barbara Seliger; Claudia Wickenhauser; Christian Grohé; Andreas A Hombach; Stefan Pabst; Hinrich Abken
Regulatory T cells with reduced repressor capacities are extensively amplified in pulmonary sarcoid lesions and sustain granuloma formation.
Clinical immunology (Orlando, Fla.) 2011;140(1):71-83.
2011: Patrick Schmidt; Hinrich Abken
The beating heart of melanomas: a minor subset of cancer cells sustains tumor growth.
Oncotarget 2011;2(4):313-20.
2011: David M Kofler; Markus Chmielewski; Gunter Rappl; Andreas Hombach; Tobias Riet; Annette Schmidt; Andreas A Hombach; Clemens-Martin Wendtner; Hinrich Abken
CD28 costimulation Impairs the efficacy of a redirected t-cell antitumor attack in the presence of regulatory t cells which can be overcome by preventing Lck activation.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(4):760-7.
2011: Patrick Schmidt; Caroline Kopecky; Andreas Hombach; Paola Zigrino; Cornelia Mauch; Hinrich Abken
Eradication of melanomas by targeted elimination of a minor subset of tumor cells.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(6):2474-9.
2011: M Chmielewski; Andreas Hombach; Hinrich Abken
CD28 cosignalling does not affect the activation threshold in a chimeric antigen receptor-redirected T-cell attack.
Gene therapy 2011;18(1):62-72.
2010: Hildegard Büning; Wolfgang Uckert; Klaus Cichutek; Robert E Hawkins; Hinrich Abken
Do CARs need a driver's license? Adoptive cell therapy with chimeric antigen receptor-redirected T cells has caused serious adverse events.
Human gene therapy 2010;21(9):1039-42.
2010: Philipp S Müther; Irina Semkova; Kristina Schmidt; Elizabeth Abari; Marc Kuebbeler; Marc Beyer; Hinrich Abken; Klaus L Meyer; Norbert Kociok; Antonia M Joussen
Conditions of retinal glial and inflammatory cell activation after irradiation in a GFP-chimeric mouse model.
Investigative ophthalmology & visual science 2010;51(9):4831-9.
2010: Robert E Hawkins; David Gilham; Reno Debets; Zelig Eshhar; Naomi Taylor; Hinrich Abken; Ton N Schumacher
Development of adoptive cell therapy for cancer: a clinical perspective.
Human gene therapy 2010;21(6):665-72.
2010: John Bridgeman; Robert E Hawkins; Andreas A Hombach; Hinrich Abken; David Gilham
Building better chimeric antigen receptors for adoptive T cell therapy.
Current gene therapy 2010;10(2):77-90.
2010: Florian Full; Manfred Lehner; Veronika Thonn; Gabriel Goetz; Brigitte Scholz; Kerstin B Kaufmann; Michael Mach; Hinrich Abken; Wolfgang Holter; Armin Ensser
T cells engineered with a cytomegalovirus-specific chimeric immunoreceptor.
Journal of virology 2010;84(8):4083-8.
2010: Matthias Laudes; F Oberhauser; D M Schulte; S Freude; R Bilkovski; J Mauer; Gunter Rappl; Hinrich Abken; M Hahn; O Schulz; Wilhelm Krone
Visfatin/PBEF/Nampt and resistin expressions in circulating blood monocytes are differentially related to obesity and type 2 diabetes in humans.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2010;42(4):268-73.
2010: Jens Michael Seeger; Patrick Schmidt; Kerstin Brinkmann; Andreas Hombach; Oliver Coutelle; Paola Zigrino; Diana Wagner-Stippich; Cornelia Mauch; Hinrich Abken; Martin Krönke; Hamid Kashkar
The proteasome inhibitor bortezomib sensitizes melanoma cells toward adoptive CTL attack.
Cancer research 2010;70(5):1825-34.
2009: Andreas Hombach; David M Kofler; Gunter Rappl; Hinrich Abken
Redirecting human CD4+CD25+ regulatory T cells from the peripheral blood with pre-defined target specificity.
Gene therapy 2009;16(9):1088-96.
2009: Guillaume Stewart-Jones; Andreas Wadle; Anja Hombach; Eugene Shenderov; Gerhard Held; Eliane Fischer; Sascha Kleber; Natko Nuber; Frank Stenner-Liewen; Stefan Bauer; Andrew McMichael; Alexander Knuth; Hinrich Abken; Andreas A Hombach; Vincenzo Cerundolo; E Yvonne Jones; Christoph Renner
Rational development of high-affinity T-cell receptor-like antibodies.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(14):5784-8.
2008: Barbara Seliger; Francesco M Marincola; Soldano Ferrone; Hinrich Abken
The complex role of B7 molecules in tumor immunology.
Trends in molecular medicine 2008;14(12):550-9.
2008: Anna Kruschinski; Andreas Moosmann; Isabel Poschke; Håkan Norell; Markus Chmielewski; Barbara Seliger; Rolf Kiessling; Thomas Blankenstein; Hinrich Abken; Jehad Charo
Engineering antigen-specific primary human NK cells against HER-2 positive carcinomas.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(45):17481-6.
2008: Gunter Rappl; Annette Schmidt; Cornelia Mauch; Andreas Hombach; Hinrich Abken
Extensive amplification of human regulatory T cells alters their functional capacities and targets them to the periphery.
Rejuvenation research 2008;11(5):915-33.
2008: Gunter Rappl; David Schrama; Andreas Hombach; Eva Katharina Meuer; Annette Schmidt; Jürgen C Becker; Hinrich Abken
CD7(-) T cells are late memory cells generated from CD7(+) T cells.
Rejuvenation research 2008;11(3):543-56.
2008: Felix Bohne; Markus Chmielewski; Gregor Ebert; Katja Wiegmann; Timo Kürschner; Andreas Schulze; Stephan Urban; Martin Krönke; Hinrich Abken; Ulrike Protzer
T cells redirected against hepatitis B virus surface proteins eliminate infected hepatocytes.
Gastroenterology 2008;134(1):239-47.
2007: Andreas Hombach; David Kofler; Anja Hombach; Gunter Rappl; Hinrich Abken
Effective proliferation of human regulatory T cells requires a strong costimulatory CD28 signal that cannot be substituted by IL-2.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(11):7924-31.
2007: Barbara Savoldo; Cliona M Rooney; Antonio Di Stasi; Hinrich Abken; Andreas Hombach; Aaron E Foster; Lan Zhang; Helen E Heslop; Malcolm K Brenner; Gianpietro Dotti
Epstein Barr virus specific cytotoxic T lymphocytes expressing the anti-CD30zeta artificial chimeric T-cell receptor for immunotherapy of Hodgkin disease.
Blood 2007;110(7):2620-30.
2007: Agnieszka Morgenroth; Marc Cartellieri; Marc Schmitz; Serap Günes; Bernd Weigle; Michael Bachmann; Hinrich Abken; E Peter Rieber; Achim Temme
Targeting of tumor cells expressing the prostate stem cell antigen (PSCA) using genetically engineered T-cells.
The Prostate 2007;67(10):1121-31.
2007: Andreas Hombach; Hinrich Abken
Costimulation tunes tumor-specific activation of redirected T cells in adoptive immunotherapy.
Cancer immunology, immunotherapy : CII 2007;56(5):731-7.
2007: Andreas Hombach; Verena Schildgen; Claudia Heuser; Ricarda Finnern; David Gilham; Hinrich Abken
T cell activation by antibody-like immunoreceptors: the position of the binding epitope within the target molecule determines the efficiency of activation of redirected T cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(7):4650-7.
2007: Heike Koehler; David Kofler; Andreas Hombach; Hinrich Abken
CD28 costimulation overcomes transforming growth factor-beta-mediated repression of proliferation of redirected human CD4+ and CD8+ T cells in an antitumor cell attack.
Cancer research 2007;67(5):2265-73.
2006: Hamid Kashkar; Jens-Michael Seeger; Andreas Hombach; Anke Deggerich; Benjamin Yazdanpanah; Olaf Utermöhlen; Gerd Heimlich; Hinrich Abken; Martin Krönke
XIAP targeting sensitizes Hodgkin lymphoma cells for cytolytic T-cell attack.
Blood 2006;108(10):3434-40.
2006: Andreas Hombach; Heike Köhler; Gunter Rappl; Hinrich Abken
Human CD4+ T cells lyse target cells via granzyme/perforin upon circumvention of MHC class II restriction by an antibody-like immunoreceptor.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(8):5668-75.
2006: Andreas Hombach; Claudia Schlimper; E Sievers; S Frank; H H Schild; T Sauerbruch; Ingo G H Schmidt-Wolf; Hinrich Abken
A recombinant anti-carcinoembryonic antigen immunoreceptor with combined CD3zeta-CD28 signalling targets T cells from colorectal cancer patients against their tumour cells.
Gut 2006;55(8):1156-64.
2005: Kai Kronfeld; Hinrich Abken; Barbara Seliger
B7-1 and B7-2 act differentially in the induction of a T cell response: their impact for a HLA-matched and HLA-mismatched anti-tumor immunotherapy.
International journal of cancer. Journal international du cancer 2005;117(5):794-9.
2005: Kai Kronfeld; Elisabeth Hochleitner; Simone Mendler; Jutta Goldschmidt; Rudolf Lichtenfels; Friedrich Lottspeich; Hinrich Abken; Barbara Seliger
B7/CD28 costimulation of T cells induces a distinct proteome pattern.
Molecular & cellular proteomics : MCP 2005;4(12):1876-87.
2005: Andreas Hombach; Claudia Heuser; Hinrich Abken
Simultaneous targeting of IL2 and IL12 to Hodgkin's lymphoma cells enhances activation of resting NK cells and tumor cell lysis.
International journal of cancer. Journal international du cancer 2005;115(2):241-7.
2004: Markus Chmielewski; Andreas Hombach; Claudia Heuser; Gregory P Adams; Hinrich Abken
T cell activation by antibody-like immunoreceptors: increase in affinity of the single-chain fragment domain above threshold does not increase T cell activation against antigen-positive target cells but decreases selectivity.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(12):7647-53.
2004: Claudia Heuser; Stefan Guhlke; Alexander Matthies; Hans Bender; Stefan Barth; Volker Diehl; Hinrich Abken; Andreas Hombach
Anti-CD30-scFv-Fc-IL-2 antibody-cytokine fusion protein that induces resting NK cells to highly efficient cytolysis of Hodgkin's lymphoma derived tumour cells.
International journal of cancer. Journal international du cancer 2004;110(3):386-94.
2004: Andreas Stallmach; Thomas Marth; B Weiss; B M Wittig; Andreas Hombach; C Schmidt; M Neurath; Martin Zeitz; Stefan Zeuzem; Hinrich Abken
An interleukin 12 p40-IgG2b fusion protein abrogates T cell mediated inflammation: anti-inflammatory activity in Crohn's disease and experimental colitis in vivo.
Gut 2004;53(3):339-45.
2003: Claudia Heuser; M Ganser; Andreas Hombach; H Brand; G Denton; Franz-Georg Hanisch; Hinrich Abken
An anti-MUC1-antibody-interleukin-2 fusion protein that activates resting NK cells to lysis of MUC1-positive tumour cells.
British journal of cancer 2003;89(6):1130-9.
2003: Claudia Heuser; Volker Diehl; Hinrich Abken; Andreas Hombach
Anti-CD30-IL-12 antibody-cytokine fusion protein that induces IFN-gamma secretion of T cells and NK cell-mediated lysis of Hodgkin's lymphoma-derived tumor cells.
International journal of cancer. Journal international du cancer 2003;106(4):545-52.
2003: Claudia Heuser; Andreas Hombach; C Lösch; K Manista; Hinrich Abken
T-cell activation by recombinant immunoreceptors: impact of the intracellular signalling domain on the stability of receptor expression and antigen-specific activation of grafted T cells.
Gene therapy 2003;10(17):1408-19.
2003: Silke Reinartz; Andreas Hombach; Siegmund Köhler; Harald Schlebusch; Diethelm Wallwiener; Hinrich Abken; Uwe Wagner
Interleukin-6 fused to an anti-idiotype antibody in a vaccine increases the specific humoral immune response against CA125+ (MUC-16) ovarian cancer.
Cancer research 2003;63(12):3234-40.
2003: Hinrich Abken; Andreas Hombach; Günter Reinhard; Angela Märten; Claudia Schlimper; Axel Glasmacher; Thomas Bieber; Ingo G H Schmidt-Wolf
Cellular immunotherapy after autologous hematopoietic stem cell transplantation: experimental strategies and clinical experiences.
Leukemia & lymphoma 2003;44(4):583-92.
2003: Barbara Seliger; Hinrich Abken; Soldano Ferrone
HLA-G and MIC expression in tumors and their role in anti-tumor immunity.
Trends in immunology 2003;24(2):82-7.
2003: Hinrich Abken; Andreas Hombach; Claudia Heuser
Immune response manipulation: recombinant immunoreceptors endow T-cells with predefined specificity.
Current pharmaceutical design 2003;9(24):1992-2001.
2003: Andreas Hombach; Claudia Heuser; Hinrich Abken
Generation, expression, and monitoring of recombinant immune receptors for use in cellular immunotherapy.
Methods in molecular biology (Clifton, N.J.) 2003;207():365-81.
2002: Andreas Hombach; Claudia Heuser; Hinrich Abken
The recombinant T cell receptor strategy: insights into structure and function of recombinant immunoreceptors on the way towards an optimal receptor design for cellular immunotherapy.
Current gene therapy 2002;2(2):211-26.
2002: Hinrich Abken; Andreas Hombach; Claudia Heuser; Kai Kronfeld; Barbara Seliger
Tuning tumor-specific T-cell activation: a matter of costimulation?
Trends in immunology 2002;23(5):240-5.
2002: Gunter Rappl; Hinrich Abken; J Marcus Muche; W Sterry; Wolfgang Tilgen; S André; H Kaltner; Selma Ugurel; Hans-Joachim Gabius; Uwe Reinhold
CD4+CD7- leukemic T cells from patients with Sézary syndrome are protected from galectin-1-triggered T cell death.
Leukemia 2002;16(5):840-5.
2002: Carsten Schmidt; Thomas Marth; Bianca M Wittig; Andreas Hombach; Hinrich Abken; Andreas Stallmach
Interleukin-12 antagonists as new therapeutic agents in inflammatory bowel disease.
Pathobiology : journal of immunopathology, molecular and cellular biology 2002;70(3):177-83.
2001: Andreas Hombach; A Wieczarkowiecz; T Marquardt; Claudia Heuser; L Usai; C Pohl; Barbara Seliger; Hinrich Abken
Tumor-specific T cell activation by recombinant immunoreceptors: CD3 zeta signaling and CD28 costimulation are simultaneously required for efficient IL-2 secretion and can be integrated into one combined CD28/CD3 zeta signaling receptor molecule.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(11):6123-31.
2001: Andreas Hombach; Claudia Heuser; T Marquardt; A Wieczarkowiecz; V Groneck; C Pohl; Hinrich Abken
CD4+ T cells engrafted with a recombinant immunoreceptor efficiently lyse target cells in a MHC antigen- and Fas-independent fashion.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(2):1090-6.
2001: Andreas Hombach; J Marcus Muche; M Gerken; Sylke Gellrich; Claudia Heuser; C Pohl; W Sterry; Hinrich Abken
T cells engrafted with a recombinant anti-CD30 receptor target autologous CD30(+) cutaneous lymphoma cells.
Gene therapy 2001;8(11):891-5.
2001: Gunter Rappl; Hinrich Abken; Dirk O Hasselmann; Wolfgang Tilgen; Selma Ugurel; Uwe Reinhold
The CD7(-) subset of CD4(+) memory T cells is prone to accelerated apoptosis that is prevented by interleukin-15 (IL-15).
Cell death and differentiation 2001;8(4):395-402.
2001: Andreas Hombach; D Sent; C Schneider; Claudia Heuser; D Koch; C Pohl; Barbara Seliger; Hinrich Abken
T-cell activation by recombinant receptors: CD28 costimulation is required for interleukin 2 secretion and receptor-mediated T-cell proliferation but does not affect receptor-mediated target cell lysis.
Cancer research 2001;61(5):1976-82.
2001: Gunter Rappl; J Marcus Muche; Hinrich Abken; W Sterry; Wolfgang Tilgen; Selma Ugurel; Uwe Reinhold
CD4(+)CD7(-) T cells compose the dominant T-cell clone in the peripheral blood of patients with Sézary syndrome.
Journal of the American Academy of Dermatology 2001;44(3):456-61.
2001: Gunter Rappl; A Kapsokefalou; Claudia Heuser; MJ Rössler; Selma Ugurel; Wolfgang Tilgen; Uwe Reinhold; Hinrich Abken
Dermal fibroblasts sustain proliferation of activated T cells via membrane-bound interleukin-15 upon long-term stimulation with tumor necrosis factor-alpha.
The Journal of investigative dermatology 2001;116(1):102-9.
2001: Hinrich Abken; Andreas Hombach; Claudia Heuser; Uwe Reinhold
A novel strategy in the elimination of disseminated melanoma cells: chimeric receptors endow T cells with tumor specificity.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 2001;158():249-64.
2000: Andreas Hombach; C Schneider; D Sent; D Koch; Ralph A Willemsen; Volker Diehl; Wolfgang Kruis; Reinder L H Bolhuis; C Pohl; Hinrich Abken
An entirely humanized CD3 zeta-chain signaling receptor that directs peripheral blood t cells to specific lysis of carcinoembryonic antigen-positive tumor cells.
International journal of cancer. Journal international du cancer 2000;88(1):115-20.
2000: L Liu; Hinrich Abken; Claudia Pföhler; Gunter Rappl; Wolfgang Tilgen; Uwe Reinhold
Accumulation of CD4+CD7- T cells in inflammatory skin lesions: evidence for preferential adhesion to vascular endothelial cells.
Clinical and experimental immunology 2000;121(1):94-9.
2000: Andreas Hombach; Claudia Heuser; M Gerken; B Fischer; K Lewalter; Volker Diehl; C Pohl; Hinrich Abken
T cell activation by recombinant FcepsilonRI gamma-chain immune receptors: an extracellular spacer domain impairs antigen-dependent T cell activation but not antigen recognition.
Gene therapy 2000;7(12):1067-75.
1999: Andreas Hombach; Claudia Heuser; R Sircar; T Tillmann; Volker Diehl; C Pohl; Hinrich Abken
Characterization of a chimeric T-cell receptor with specificity for the Hodgkin's lymphoma-associated CD30 antigen.
Journal of immunotherapy (Hagerstown, Md. : 1997) 1999;22(6):473-80.
1999: S Naderi; P Hofmann; S Seiter; W Tilgen; Hinrich Abken; Uwe Reinhold
CD2-mediated CD59 stimulation in keratinocytes results in secretion of IL-1alpha, IL-6, and GM-CSF: implications for the interaction of keratinocytes with intraepidermal T lymphocytes.
International journal of molecular medicine 1999;3(6):609-14.
1999: Uwe Reinhold; L Liu; H C Lüdtke-Handjery; Claudia Heuser; Andreas Hombach; X Wang; Wolfgang Tilgen; S Ferrone; Hinrich Abken
Specific lysis of melanoma cells by receptor grafted T cells is enhanced by anti-idiotypic monoclonal antibodies directed to the scFv domain of the receptor.
The Journal of investigative dermatology 1999;112(5):744-50.
1999: Andreas Hombach; D Koch; R Sircar; Claudia Heuser; Volker Diehl; Wolfgang Kruis; C Pohl; Hinrich Abken
A chimeric receptor that selectively targets membrane-bound carcinoembryonic antigen (mCEA) in the presence of soluble CEA.
Gene therapy 1999;6(2):300-4.
1999: Andreas Hombach; C Pohl; Uwe Reinhold; Hinrich Abken
Grafting T cells with tumor specificity: the chimeric receptor strategy for use in immunotherapy of malignant diseases.
Hybridoma 1999;18(1):57-61.
1998: Andreas Hombach; C Pohl; Claudia Heuser; R Sircar; D Koch; Volker Diehl; Hinrich Abken
Generation of the single chain antibody fragment conserves the idiotypic profile of the anti-CD30 monoclonal antibody HRS3.
Scandinavian journal of immunology 1998;48(5):497-501.
1998: Andreas Hombach; C Pohl; Claudia Heuser; R Sircar; Volker Diehl; Hinrich Abken
Isolation of single chain antibody fragments with specificity for cell surface antigens by phage display utilizing internal image anti-idiotypic antibodies.
Journal of immunological methods 1998;218(1-2):53-61.
1998: Andreas Hombach; R Sircar; Claudia Heuser; T Tillmann; Volker Diehl; Wolfgang Kruis; C Pohl; Hinrich Abken
Chimeric anti-TAG72 receptors with immunoglobulin constant Fc domains and gamma or zeta signalling chains.
International journal of molecular medicine 1998;2(1):99-103.
1998: Andreas Hombach; Claudia Heuser; R Sircar; T Tillmann; Volker Diehl; C Pohl; Hinrich Abken
An anti-CD30 chimeric receptor that mediates CD3-zeta-independent T-cell activation against Hodgkin's lymphoma cells in the presence of soluble CD30.
Cancer research 1998;58(6):1116-9.
1998: Hinrich Abken; Andreas Hombach; Uwe Reinhold; S Ferrone
Can combined T-cell- and antibody-based immunotherapy outsmart tumor cells?
Immunology today 1998;19(1):2-5.
1997: J Fluck; S Schachtschneider; Hinrich Abken
Autocrine proliferating B cells are susceptible to terminal differentiation and apoptosis.
Cell death and differentiation 1997;4(8):824-33.
1997: Andreas Hombach; Claudia Heuser; R Sircar; T Tillmann; Volker Diehl; Wolfgang Kruis; C Pohl; Hinrich Abken
T cell targeting of TAG72+ tumor cells by a chimeric receptor with antibody-like specificity for a carbohydrate epitope.
Gastroenterology 1997;113(4):1163-70.
1997: Uwe Reinhold; Hinrich Abken
CD4+ CD7- T cells: a separate subpopulation of memory T cells?
Journal of clinical immunology 1997;17(4):265-71.
1997: Heribert Bohlen; Oliver Manzke; S Titzer; Johann Lorenzen; Martin Hafner; Andreas Engert; Hinrich Abken; Jürgen Wolf; Volker Diehl; Hans Tesch
Prevention of Epstein-Barr virus-induced human B-cell lymphoma in severe combined immunodeficient mice treated with CD3xCD19 bispecific antibodies, CD28 monospecific antibodies, and autologous T cells.
Cancer research 1997;57(9):1704-9.
1997: Hinrich Abken; Andreas Hombach; Claudia Heuser; R Sircar; C Pohl; Uwe Reinhold
Chimeric T-cell receptors: highly specific tools to target cytotoxic T-lymphocytes to tumour cells.
Cancer treatment reviews 1997;23(2):97-112.
1997: Uwe Reinhold; H C Lüdtke-Handjery; S Schnautz; HW Kreysel; Hinrich Abken
The analysis of tyrosinase-specific mRNA in blood samples of melanoma patients by RT-PCR is not a useful test for metastatic tumor progression.
The Journal of investigative dermatology 1997;108(2):166-9.
1996: Uwe Reinhold; L Liu; J Sesterhenn; S Schnautz; Hinrich Abken
The CD7- T cell subset represents the majority of IL-5-secreting cells within CD4+CD45RA- T cells.
Clinical and experimental immunology 1996;106(3):555-9.
1996: B Reifenrath-Biesel; Hinrich Abken
In vitro display of DNA elements that modulate the RNA transcription in cis or in trans directions.
Gene 1996;181(1-2):135-7.
1996: Uwe Reinhold; L Liu; J Sesterhenn; Hinrich Abken
CD7-negative T cells represent a separate differentiation pathway in a subset of post-thymic helper T cells.
Immunology 1996;89(3):391-6.
1995: R Hegger; Hinrich Abken
The short DNA sequences in the cytoplasm of Ehrlich ascites tumor cells are tightly associated with proteins.
Physiological chemistry and physics and medical NMR 1995;27(4):321-8.
1995: Udo Koehler; Hinrich Abken; Friedrich Grummt; Johannes Wienberg; Ulrich H Weidle
A novel type of unstable homogeneously staining region with a head-to-tail arrangement: spontaneous decay and reintegration of DNA elements into a plethora of new chromosomal sites.
Cytogenetics and cell genetics 1995;68(1-2):33-8.
1995: Uwe Reinhold; Hinrich Abken
Cutaneous T-cell lymphoma: molecular genetics, immunology and pathogenesis.
European journal of cancer (Oxford, England : 1990) 1995;31A(5):793-9.
1994: Hinrich Abken; Friedrich Grummt; U H Weidle
Tumorigenic transformation of established murine fibroblasts by transfection with amplification promoting DNA elements.
European journal of cell biology 1994;65(1):114-20.
1994: M Moll; Uwe Reinhold; S Kukel; Hinrich Abken; R Müller; I Oltermann; H W Kreysel
CD7-negative helper T cells accumulate in inflammatory skin lesions.
The Journal of investigative dermatology 1994;102(3):328-32.
1993: Hinrich Abken; R Hegger; C Bützler; Klaus Willecke
Short DNA sequences from the cytoplasm of mouse tumor cells induce immortalization of human lymphocytes in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(14):6518-22.
1993: Hinrich Abken; R Hegger; Klaus Willecke
A DNA-binding zinc-protein increases the immortalizing activity of an extrachromosomal DNA sequence from mouse L929 cells.
Annals of the New York Academy of Sciences 1993;684():193-5.
1993: Uwe Reinhold; Hinrich Abken; S Kukel; M Moll; R Müller; I Oltermann; H W Kreysel
CD7- T cells represent a subset of normal human blood lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(5):2081-9.
1992: Hinrich Abken; J Fluck; Klaus Willecke
Four cell-secreted cytokines act synergistically to maintain long term proliferation of human B cell lines in vitro.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(8):2785-94.
1992: Hinrich Abken; B Reifenrath
A procedure to standardize CAT reporter gene assay.
Nucleic acids research 1992;20(13):3527.
1991: Hinrich Abken; C Bützler
Re-organization of the immunoglobulin kappa gene on both alleles is not an obligatory prerequisite for Ig lambda gene expression in human cells.
Immunology 1991;74(4):709-13.
1991: R Bialek; Hinrich Abken
A fluorometric assay to monitor mitogenic stimulation of human lymphocytes.
Journal of immunological methods 1991;144(2):223-9.
1991: Uwe Reinhold; Hinrich Abken; S Kukel; B Goeden; M Uerlich; U Neumann; H W Kreysel
Tumor-infiltrating lymphocytes isolated from a Ki-1-positive large cell lymphoma of the skin. Phenotypic characterization and analysis of cytokine secretion.
Cancer 1991;68(10):2155-60.
1990: Hinrich Abken; C Bützler; Klaus Willecke
Altered expression of proto-oncogenes in human lymphoid cells immortalized by transfection with extrachromosomal DNA of mouse L cells.
Anticancer research 1990;10(1):73-80.
1990: Hinrich Abken; J Fluck; Klaus Willecke
[Human lymphocyte transformation after immortalization by transfection with cytoplasmic DNA from mouse L cells of the cytokines IL-1alpha, IL-6 and TNF].
Verhandlungen der Deutschen Gesellschaft für Pathologie 1990;74():381-5.
1988: Hinrich Abken; C Bützler; Klaus Willecke
Immortalization of human lymphocytes by transfection with DNA from mouse L929 cytoplasts.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(2):468-72.
1987: Hinrich Abken; C Bützler; Klaus Willecke
Adenovirus type 5 persisting in human lymphocytes is unlikely to be involved in immortalization of lymphoid cells by fusion with cytoplasts or by transfection with DNA of mouse L cells.
Anticancer research 1987;7(4A):553-8.