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Paolo Dotto

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Anatomy

Living Beings

Physiology

Chemicals & Drugs

Disorders

Neoplastic Cell Transformation

Genes & Molecular Sequences

ras Genes

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Co-Publications
Name
10
Calautti, Enzo
8
Lefort, Karine
7
Brissette, Janice
6
Tommasi di Vignano, Alice
5
Talora, Claudio
5
chiorino, giovanna
5
Mammucari, Cristina
5
Mandinova, Anna
5
Devgan, Vikram
4
Di Cunto, Ferdinando
4
Okuyama, Ryuhei
3
Nguyen, Bach-Cuc
3
Foitzik, Kerstin
3
Botchkarev, Vladimir
3
Brisken, Cathrin

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Publications

TOP 3
Dotto G Paolo
Crosstalk of Notch with p53 and p63 in cancer growth control.
Pradervand Sylvain; Weber Johann; Thomas Jérôme; Bueno Manuel; Wirapati Pratyaksha; Lefort Karine; Dotto G Paolo; Harshman Keith
Impact of normalization on miRNA microarray expression profiling.
Dotto G P
Notch tumor suppressor function.

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All Publications

2009: Dotto G Paolo
Crosstalk of Notch with p53 and p63 in cancer growth control.
Nature reviews. Cancer 2009;9(8):587-95.
2009: Pradervand Sylvain; Weber Johann; Thomas Jérôme; Bueno Manuel; Wirapati Pratyaksha; Lefort Karine; Dotto G Paolo; Harshman Keith
Impact of normalization on miRNA microarray expression profiling.
RNA (New York, N.Y.) 2009;15(3):493-501.
2008: Dotto G P
Notch tumor suppressor function.
Oncogene 2008;27(38):5115-23.
2008: Kolev Vihren; Mandinova Anna; Guinea-Viniegra Juan; Hu Bing; Lefort Karine; Lambertini Chiara; Neel Victor; Dummer Reinhard; Wagner Erwin F; Dotto G Paolo
EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer.
Nature cell biology 2008;10(8):902-11.
2008: Mandinova Anna; Lefort Karine; Tommasi di Vignano Alice; Stonely Wesley; Ostano Paola; Chiorino Giovanna; Iwaki Haruhi; Nakanishi Jotaro; Dotto G Paolo
The FoxO3a gene is a key negative target of canonical Notch signalling in the keratinocyte UVB response.
The EMBO journal 2008;27(8):1243-54.
2007: Lefort Karine; Mandinova Anna; Ostano Paola; Kolev Vihren; Calpini Valerie; Kolfschoten Ingrid; Devgan Vikram; Lieb Jocelyn; Raffoul Wassim; Hohl Daniel; Neel Victor; Garlick Jonathan; Chiorino Giovanna; Dotto G Paolo
Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases.
Genes & development 2007;21(5):562-77.
2006: Ongusaha Pat P; Kim Hyung-Gu; Boswell Sarah A; Ridley Anne J; Der Channing J; Dotto G Paolo; Kim Young-Bum; Aaronson Stuart A; Lee Sam W
RhoE is a pro-survival p53 target gene that inhibits ROCK I-mediated apoptosis in response to genotoxic stress.
Current biology : CB 2006;16(24):2466-72.
2006: Sharov Andrey A; Sharova Tatyana Y; Mardaryev Andrei N; Tommasi di Vignano Alice; Atoyan Ruzanna; Weiner Lorin; Yang Shi; Brissette Janice L; Dotto G Paolo; Botchkarev Vladimir A
Bone morphogenetic protein signaling regulates the size of hair follicles and modulates the expression of cell cycle-associated genes.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(48):18166-71.
2006: Devgan Vikram; Nguyen Bach-Cuc; Oh Heysun; Dotto G Paolo
p21WAF1/Cip1 suppresses keratinocyte differentiation independently of the cell cycle through transcriptional up-regulation of the IGF-I gene.
The Journal of biological chemistry 2006;281(41):30463-70.
2006: Nguyen Bach-Cuc; Lefort Karine; Mandinova Anna; Antonini Dario; Devgan Vikram; Della Gatta Giusy; Koster Maranke I; Zhang Zhuo; Wang Jian; Tommasi di Vignano Alice; Kitajewski Jan; Chiorino Giovanna; Roop Dennis R; Missero Caterina; Dotto G Paolo
Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation.
Genes & development 2006;20(8):1028-42.
2006: Ayyanan Ayyakannu; Civenni Gianluca; Ciarloni Laura; Morel Catherine; Mueller Nathalie; Lefort Karine; Mandinova Anna; Raffoul Wassim; Fiche Maryse; Dotto Gian Paolo; Brisken Cathrin
Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(10):3799-804.
2005: Wang Jian; Devgan Vikram; Corrado Marcella; Prabhu Nita S; El-Deiry Wafik S; Riccardi Carlo; Pandolfi Pier Paolo; Missero Caterina; Dotto G Paolo
Glucocorticoid-induced tumor necrosis factor receptor is a p21Cip1/WAF1 transcriptional target conferring resistance of keratinocytes to UV light-induced apoptosis.
The Journal of biological chemistry 2005;280(45):37725-31.
2005: Dotto G Paolo; Cotsarelis George
Developmental biology. Rac1 up for epidermal stem cells.
Science (New York, N.Y.) 2005;309(5736):890-1.
2005: Grossi Maddalena; Hiou-Feige Agnès; Tommasi Di Vignano Alice; Calautti Enzo; Ostano Paola; Lee Sam; Chiorino Giovanna; Dotto G Paolo
Negative control of keratinocyte differentiation by Rho/CRIK signaling coupled with up-regulation of KyoT1/2 (FHL1) expression.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(32):11313-8.
2005: Devgan Vikram; Mammucari Cristina; Millar Sarah E; Brisken Cathrin; Dotto G Paolo
p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation.
Genes & development 2005;19(12):1485-95.
2005: Mammucari Cristina; Tommasi di Vignano Alice; Sharov Andrey A; Neilson Joel; Havrda Matthew C; Roop Dennis R; Botchkarev Vladimir A; Crabtree Gerald R; Dotto G Paolo
Integration of Notch 1 and calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control.
Developmental cell 2005;8(5):665-76.
2004: Lefort Karine; Dotto G Paolo
Notch signaling in the integrated control of keratinocyte growth/differentiation and tumor suppression.
Seminars in cancer biology 2004;14(5):374-86.
2004: Okuyama Ryuhei; LeFort Karine; Dotto G Paolo
A dynamic model of keratinocyte stem cell renewal and differentiation: role of the p21WAF1/Cip1 and Notch1 signaling pathways.
The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research 2004;9(3):248-52.
2004: Dotto G Paolo; Silke John
More than cell death: caspases and caspase inhibitors on the move.
Developmental cell 2004;7(1):2-3.
2004: Okuyama Ryuhei; Nguyen Bach-Cuc; Talora Claudio; Ogawa Eisaku; Tommasi di Vignano Alice; Lioumi Maria; Chiorino Giovanna; Tagami Hachiro; Woo Minna; Dotto G Paolo
High commitment of embryonic keratinocytes to terminal differentiation through a Notch1-caspase 3 regulatory mechanism.
Developmental cell 2004;6(4):551-62.
2004: Itoh Fumiko; Itoh Susumu; Goumans Marie-José; Valdimarsdottir Gudrun; Iso Tatsuya; Dotto G Paolo; Hamamori Yasuo; Kedes Larry; Kato Mitsuyasu; ten Dijke Pt Peter
Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells.
The EMBO journal 2004;23(3):541-51.
2003: Nicolas Michael; Wolfer Anita; Raj Kenneth; Kummer J Alain; Mill Pleasantine; van Noort Mascha; Hui Chi-chung; Clevers Hans; Dotto G Paolo; Radtke Freddy
Notch1 functions as a tumor suppressor in mouse skin.
Nature genetics 2003;33(3):416-21.
2003: Liu Zhao-Jun; Shirakawa Takashi; Li Yan; Soma Akinobu; Oka Masahiro; Dotto G Paolo; Fairman Ronald M; Velazquez Omaida C; Herlyn Meenhard
Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis.
Molecular and cellular biology 2003;23(1):14-25.
2002: Brisken Cathrin; Ayyannan Ayyakkannu; Nguyen Cuc; Heineman Anna; Reinhardt Ferenc; Tan Jian; Dey S K; Dotto G Paolo; Weinberg Robert A;
IGF-2 is a mediator of prolactin-induced morphogenesis in the breast.
Developmental cell 2002;3(6):877-87.
2002: Talora Claudio; Sgroi Dennis C; Crum Christopher P; Dotto G Paolo
Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation.
Genes & development 2002;16(17):2252-63.
2002: Oh Hyesun; Mammucari Cristina; Nenci Arianna; Cabodi Sara; Cohen Stanley N; Dotto G Paolo
Negative regulation of cell growth and differentiation by TSG101 through association with p21(Cip1/WAF1).
Proceedings of the National Academy of Sciences of the United States of America 2002;99(8):5430-5.
2002: Calautti Enzo; Grossi Maddalena; Mammucari Cristina; Aoyama Yumi; Pirro Maria; Ono Yoshitaka; Li Jie; Dotto G Paolo
Fyn tyrosine kinase is a downstream mediator of Rho/PRK2 function in keratinocyte cell-cell adhesion.
The Journal of cell biology 2002;156(1):137-48.
2002: Seykora John T; Mei Lijuan; Dotto G Paolo; Stein Paul L
'Srcasm: a novel Src activating and signaling molecule.
The Journal of biological chemistry 2002;277(4):2812-22.
2001: Santini M P; Talora C; Seki T; Bolgan L; Dotto G P
Cross talk among calcineurin, Sp1/Sp3, and NFAT in control of p21(WAF1/CIP1) expression in keratinocyte differentiation.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(17):9575-80.
2001: Rangarajan A; Talora C; Okuyama R; Nicolas M; Mammucari C; Oh H; Aster J C; Krishna S; Metzger D; Chambon P; Miele L; Aguet M; Radtke F; Dotto G P
Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation.
The EMBO journal 2001;20(13):3427-36.
2000: Cabodi S; Calautti E; Talora C; Kuroki T; Stein P L; Dotto G P
A PKC-eta/Fyn-dependent pathway leading to keratinocyte growth arrest and differentiation.
Molecular cell 2000;6(5):1121-9.
2000: Di Cunto F; Imarisio S; Hirsch E; Broccoli V; Bulfone A; Migheli A; Atzori C; Turco E; Triolo R; Dotto G P; Silengo L; Altruda F
Defective neurogenesis in citron kinase knockout mice by altered cytokinesis and massive apoptosis.
Neuron 2000;28(1):115-27.
2000: Dotto G P
p21(WAF1/Cip1): more than a break to the cell cycle?
Biochimica et biophysica acta 2000;1471(1):M43-56.
2000: Foitzik K; Lindner G; Mueller-Roever S; Maurer M; Botchkareva N; Botchkarev V; Handjiski B; Metz M; Hibino T; Soma T; Dotto G P; Paus R
Control of murine hair follicle regression (catagen) by TGF-beta1 in vivo.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(5):752-60.
1999: Foitzik K; Paus R; Doetschman T; Dotto G P
The TGF-beta2 isoform is both a required and sufficient inducer of murine hair follicle morphogenesis.
Developmental biology 1999;212(2):278-89.
1999: Topley G I; Okuyama R; Gonzales J G; Conti C; Dotto G P
p21(WAF1/Cip1) functions as a suppressor of malignant skin tumor formation and a determinant of keratinocyte stem-cell potential.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(16):9089-94.
1999: Li J; Foitzik K; Calautti E; Baden H; Doetschman T; Dotto G P
TGF-beta3, but not TGF-beta1, protects keratinocytes against 12-O-tetradecanoylphorbol-13-acetate-induced cell death in vitro and in vivo.
The Journal of biological chemistry 1999;274(7):4213-9.
1999: Dotto G P
Signal transduction pathways controlling the switch between keratinocyte growth and differentiation.
Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists 1999;10(4):442-57.
1998: Di Cunto F; Calautti E; Hsiao J; Ong L; Topley G; Turco E; Dotto G P
Citron rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the Rho-Rac-binding protein Citron.
The Journal of biological chemistry 1998;273(45):29706-11.
1998: Ortel B; Chen N; Brissette J; Dotto G P; Maytin E; Hasan T
Differentiation-specific increase in ALA-induced protoporphyrin IX accumulation in primary mouse keratinocytes.
British journal of cancer 1998;77(11):1744-51.
1998: Di Cunto F; Topley G; Calautti E; Hsiao J; Ong L; Seth P K; Dotto G P
Inhibitory function of p21Cip1/WAF1 in differentiation of primary mouse keratinocytes independent of cell cycle control.
Science (New York, N.Y.) 1998;280(5366):1069-72.
1997: Kamimura J; Lee D; Baden H P; Brissette J; Dotto G P
Primary mouse keratinocyte cultures contain hair follicle progenitor cells with multiple differentiation potential.
The Journal of investigative dermatology 1997;109(4):534-40.
1997: Prowse D M; Bolgan L; Molnár A; Dotto G P
Involvement of the Sp3 transcription factor in induction of p21Cip1/WAF1 in keratinocyte differentiation.
The Journal of biological chemistry 1997;272(2):1308-14.
1996: Missero C; Di Cunto F; Kiyokawa H; Koff A; Dotto G P
The absence of p21Cip1/WAF1 alters keratinocyte growth and differentiation and promotes ras-tumor progression.
Genes & development 1996;10(23):3065-75.
1996: Brissette J L; Li J; Kamimura J; Lee D; Dotto G P
The product of the mouse nude locus, Whn, regulates the balance between epithelial cell growth and differentiation.
Genes & development 1996;10(17):2212-21.
1995: Calautti E; Missero C; Stein P L; Ezzell R M; Dotto G P
fyn tyrosine kinase is involved in keratinocyte differentiation control.
Genes & development 1995;9(18):2279-91.
1995: Missero C; Calautti E; Eckner R; Chin J; Tsai L H; Livingston D M; Dotto G P
Involvement of the cell-cycle inhibitor Cip1/WAF1 and the E1A-associated p300 protein in terminal differentiation.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(12):5451-5.
1994: Ramón y Cajal S; Missero C; Marchetti E; Dotto G P
Dermal fibroblasts tumor suppression of ras-transformed keratinocytes is associated with induction of squamous cell differentiation.
The American journal of pathology 1994;145(4):846-55.
1994: Filvaroff E; Calautti E; Reiss M; Dotto G P
Functional evidence for an extracellular calcium receptor mechanism triggering tyrosine kinase activation associated with mouse keratinocyte differentiation.
The Journal of biological chemistry 1994;269(34):21735-40.
1994: Brissette J L; Kumar N M; Gilula N B; Hall J E; Dotto G P
Switch in gap junction protein expression is associated with selective changes in junctional permeability during keratinocyte differentiation.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(14):6453-7.
1993: Escherick J S; DiCunto F; Flanders K C; Missero C; Dotto G P
Transforming growth factor beta 1 induction is associated with transforming growth factors beta 2 and beta 3 down-modulation in 12-O-tetradecanoylphorbol-13-acetate-induced skin hyperplasia.
Cancer research 1993;53(22):5517-22.
1993: Florin-Christensen M; Missero C; Florin-Christensen J; Tranque P; Ramon y Cajal S; Dotto G P
Counteracting effects of E1a transformation on cAMP growth inhibition.
Experimental cell research 1993;207(1):57-61.
1993: Missero C; Serra C; Stenn K; Dotto G P
Skin-specific expression of a truncated E1a oncoprotein binding to p105-Rb leads to abnormal hair follicle maturation without increased epidermal proliferation.
The Journal of cell biology 1993;121(5):1109-20.
1993: Brissette J L; Missero C; Yuspa S H; Dotto G P
Different levels of v-Ha-ras p21 expression in primary keratinocytes transformed with Harvey sarcoma virus correlate with benign versus malignant behavior.
Molecular carcinogenesis 1993;7(1):21-5.
1992: Filvaroff E; Calautti E; McCormick F; Dotto G P
Specific changes of Ras GTPase-activating protein (GAP) and a GAP-associated p62 protein during calcium-induced keratinocyte differentiation.
Molecular and cellular biology 1992;12(12):5319-28.
1992: Florin-Christensen M; Missero C; Dotto G P; Florin-Christensen J
The E1a gene prevents inhibition of keratinocyte proliferation by dexamethasone.
Experimental cell research 1992;203(1):285-8.
1991: Leptak C; Ramon y Cajal S; Kulke R; Horwitz B H; Riese D J; Dotto G P; DiMaio D
Tumorigenic transformation of murine keratinocytes by the E5 genes of bovine papillomavirus type 1 and human papillomavirus type 16.
Journal of virology 1991;65(12):7078-83.
1991: Missero C; Ramon y Cajal S; Dotto G P
Escape from transforming growth factor beta control and oncogene cooperation in skin tumor development.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(21):9613-7.
1991: Brissette J L; Kumar N M; Gilula N B; Dotto G P
The tumor promoter 12-O-tetradecanoylphorbol-13-acetate and the ras oncogene modulate expression and phosphorylation of gap junction proteins.
Molecular and cellular biology 1991;11(10):5364-71.
1991: Missero C; Filvaroff E; Dotto G P
Induction of transforming growth factor beta 1 resistance by the E1A oncogene requires binding to a specific set of cellular proteins.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(8):3489-93.
1991: Ramon y Cajal S; Suster S; Halaban R; Filvaroff E; Dotto G P
Induction of different morphologic features of malignant melanoma and pigmented lesions after transformation of murine melanocytes with bFGF-cDNA and H-ras, myc, neu, and E1a oncogenes.
The American journal of pathology 1991;138(2):349-58.
1990: Filvaroff E; Stern D F; Dotto G P
Tyrosine phosphorylation is an early and specific event involved in primary keratinocyte differentiation.
Molecular and cellular biology 1990;10(3):1164-73.
1989: Dotto G P; Moellmann G; Ghosh S; Edwards M; Halaban R
Transformation of murine melanocytes by basic fibroblast growth factor cDNA and oncogenes and selective suppression of the transformed phenotype in a reconstituted cutaneous environment.
The Journal of cell biology 1989;109(6 Pt 1):3115-28.
1989: Dotto G P; el-Fouly M H; Nelson C; Trosko J E
Similar and synergistic inhibition of gap-junctional communication by ras transformation and tumor promoter treatment of mouse primary keratinocytes.
Oncogene 1989;4(5):637-41.
1988: Dotto G P; Weinberg R A; Ariza A
Malignant transformation of mouse primary keratinocytes by Harvey sarcoma virus and its modulation by surrounding normal cells.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(17):6389-93.
1988: Dotto G P; O'Connell J; Patskan G; Conti C; Ariza A; Slaga T J
Malignant progression of papilloma-derived keratinocytes: differential effects of the ras, neu, and p53 oncogenes.
Molecular carcinogenesis 1988;1(3):171-9.

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