Gordon Dougan

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Goulding David; Thompson Harold; Emerson Jenny; Fairweather Neil F; Dougan Gordon; Douce Gill R
Distinctive profiles of infection and pathology in hamsters infected with Clostridium difficile strains 630 and B1.
Hall Lindsay J; Clare Simon; Pickard Derek; Clark Simon O; Kelly Dominic L F; El Ghany Moataz Abd; Hale Christine; Dietrich Jes; Andersen Peter; Marsh Philip D; Dougan Gordon
Characterisation of a live Salmonella vaccine stably expressing the Mycobacterium tuberculosis Ag85B-ESAT6 fusion protein.
Lawley Trevor D; Croucher Nicholas J; Yu Lu; Clare Simon; Sebaihia Mohammed; Goulding David; Pickard Derek J; Parkhill Julian; Choudhary Jyoti; Dougan Gordon
Proteomic and genomic characterization of highly infectious Clostridium difficile 630 spores.

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All Publications

2009: Goulding David; Thompson Harold; Emerson Jenny; Fairweather Neil F; Dougan Gordon; Douce Gill R
Distinctive profiles of infection and pathology in hamsters infected with Clostridium difficile strains 630 and B1.
Infection and immunity 2009;77(12):5478-85.
2009: Hall Lindsay J; Clare Simon; Pickard Derek; Clark Simon O; Kelly Dominic L F; El Ghany Moataz Abd; Hale Christine; Dietrich Jes; Andersen Peter; Marsh Philip D; Dougan Gordon
Characterisation of a live Salmonella vaccine stably expressing the Mycobacterium tuberculosis Ag85B-ESAT6 fusion protein.
Vaccine 2009;27(49):6894-904.
2009: Lawley Trevor D; Croucher Nicholas J; Yu Lu; Clare Simon; Sebaihia Mohammed; Goulding David; Pickard Derek J; Parkhill Julian; Choudhary Jyoti; Dougan Gordon
Proteomic and genomic characterization of highly infectious Clostridium difficile 630 spores.
Journal of bacteriology 2009;191(17):5377-86.
2009: Bushell Ellen S C; Ecker Andrea; Schlegelmilch Timm; Goulding David; Dougan Gordon; Sinden Robert E; Christophides George K; Kafatos Fotis C; Vlachou Dina
Paternal effect of the nuclear formin-like protein MISFIT on Plasmodium development in the mosquito vector.
PLoS pathogens 2009;5(8):e1000539.
2009: Holt Kathryn E; Teo Yik Y; Li Heng; Nair Satheesh; Dougan Gordon; Wain John; Parkhill Julian
Detecting SNPs and estimating allele frequencies in clonal bacterial populations by sequencing pooled DNA.
Bioinformatics (Oxford, England) 2009;25(16):2074-5.
2009: Perkins Timothy T; Kingsley Robert A; Fookes Maria C; Gardner Paul P; James Keith D; Yu Lu; Assefa Samuel A; He Miao; Croucher Nicholas J; Pickard Derek J; Maskell Duncan J; Parkhill Julian; Choudhary Jyoti; Thomson Nicholas R; Dougan Gordon
A strand-specific RNA-Seq analysis of the transcriptome of the typhoid bacillus Salmonella typhi.
PLoS genetics 2009;5(7):e1000569.
2009: Yu Jun; Rossi Raffaella; Hale Christine; Goulding David; Dougan Gordon
Interaction of enteric bacterial pathogens with murine embryonic stem cells.
Infection and immunity 2009;77(2):585-97.
2009: Phan Minh-Duy; Kidgell Claire; Nair Satheesh; Holt Kathryn E; Turner Arthur K; Hinds Jason; Butcher Philip; Cooke Fiona J; Thomson Nicholas R; Titball Richard; Bhutta Zulfiqar A; Hasan Rumina; Dougan Gordon; Wain John
Variation in Salmonella enterica serovar typhi IncHI1 plasmids during the global spread of resistant typhoid fever.
Antimicrobial agents and chemotherapy 2009;53(2):716-27.
2009: Berger Cedric N; Shaw Robert K; Brown Derek J; Mather Henry; Clare Simon; Dougan Gordon; Pallen Mark J; Frankel Gad
Interaction of Salmonella enterica with basil and other salad leaves.
The ISME journal 2009;3(2):261-5.
2009: Dougan Gordon
Does the Trojan horse have an Achilles' heel?
The New England journal of medicine 2009;360(1):83-4.
2009: Stabler Richard A; He Miao; Dawson Lisa; Martin Melissa; Valiente Esmeralda; Corton Craig; Lawley Trevor D; Sebaihia Mohammed; Quail Michael A; Rose Graham; Gerding Dale N; Gibert Maryse; Popoff Michel R; Parkhill Julian; Dougan Gordon; Wren Brendan W
Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium.
Genome biology 2009;10(9):R102.
2009: Holt Kathryn E; Thomson Nicholas R; Wain John; Langridge Gemma C; Hasan Rumina; Bhutta Zulfiqar A; Quail Michael A; Norbertczak Halina; Walker Danielle; Simmonds Mark; White Brian; Bason Nathalie; Mungall Karen; Dougan Gordon; Parkhill Julian
Pseudogene accumulation in the evolutionary histories of Salmonella enterica serovars Paratyphi A and Typhi.
BMC genomics 2009;10():36.
2008: Cooke Fiona J; Brown Derek J; Fookes Maria; Pickard Derek; Ivens Alasdair; Wain John; Roberts Mark; Kingsley Robert A; Thomson Nicholas R; Dougan Gordon
Characterization of the genomes of a diverse collection of Salmonella enterica serovar Typhimurium definitive phage type 104.
Journal of bacteriology 2008;190(24):8155-62.
2008: Holt Kathryn E; Parkhill Julian; Mazzoni Camila J; Roumagnac Philippe; Weill François-Xavier; Goodhead Ian; Rance Richard; Baker Stephen; Maskell Duncan J; Wain John; Dolecek Christiane; Achtman Mark; Dougan Gordon
High-throughput sequencing provides insights into genome variation and evolution in Salmonella Typhi.
Nature genetics 2008;40(8):987-93.
2008: Bishop Anne; House Deborah; Perkins Timothy; Baker Stephen; Kingsley Robert A; Dougan Gordon
Interaction of Salmonella enterica serovar Typhi with cultured epithelial cells: roles of surface structures in adhesion and invasion.
Microbiology (Reading, England) 2008;154(Pt 7):1914-26.
2008: Baker Stephen; Pickard Derek; Whitehead Sally; Farrar Jeremy; Dougan Gordon
Mobilization of the incQ plasmid R300B with a chromosomal conjugation system in Salmonella enterica serovar typhi.
Journal of bacteriology 2008;190(11):4084-7.
2008: Baker Stephen; Holt Kathryn; van de Vosse Esther; Roumagnac Philippe; Whitehead Sally; King Emma; Ewels Philip; Keniry Andrew; Weill François-Xavier; Lightfoot Diane; van Dissel Jaap T; Sanderson Kenneth E; Farrar Jeremy; Achtman Mark; Deloukas Panagiotis; Dougan Gordon
High-throughput genotyping of Salmonella enterica serovar Typhi allowing geographical assignment of haplotypes and pathotypes within an urban District of Jakarta, Indonesia.
Journal of clinical microbiology 2008;46(5):1741-6.
2008: MacLennan Calman A; Gondwe Esther N; Msefula Chisomo L; Kingsley Robert A; Thomson Nicholas R; White Sarah A; Goodall Margaret; Pickard Derek J; Graham Stephen M; Dougan Gordon; Hart C Anthony; Molyneux Malcolm E; Drayson Mark T
The neglected role of antibody in protection against bacteremia caused by nontyphoidal strains of Salmonella in African children.
The Journal of clinical investigation 2008;118(4):1553-62.
2008: Pickard Derek; Thomson Nicholas R; Baker Stephen; Wain John; Pardo Mercedes; Goulding David; Hamlin Nancy; Choudhary Jyoti; Threfall John; Dougan Gordon
Molecular characterization of the Salmonella enterica serovar Typhi Vi-typing bacteriophage E1.
Journal of bacteriology 2008;190(7):2580-7.
2008: House Deborah; Ho Vo A; Diep To S; Chinh Nguyen T; Bay Phan V; Vinh Ha; Duc Minh; Parry Christopher M; Dougan Gordon; White Nicholas J; Farrar Jeremy J; Hien Tran Tinh; Wain John
Antibodies to the Vi capsule of Salmonella Typhi in the serum of typhoid patients and healthy control subjects from a typhoid endemic region.
Journal of infection in developing countries 2008;2(4):308-12.
2007: Baker Stephen; Holt Kathryn; Whitehead Sally; Goodhead Ian; Perkins Tim; Stocker Bruce; Hardy Jonathan; Dougan Gordon
A linear plasmid truncation induces unidirectional flagellar phase change in H:z66 positive Salmonella Typhi.
Molecular microbiology 2007;66(5):1207-18.
2007: Bishop Anne L; Wiles Siouxsie; Dougan Gordon; Frankel Gad
Cell attachment properties and infectivity of host-adapted and environmentally adapted Citrobacter rodentium.
Microbes and infection / Institut Pasteur 2007;9(11):1316-24.
2007: Petty Nicola K; Toribio Ana L; Goulding David; Foulds Ian; Thomson Nicholas; Dougan Gordon; Salmond George P C
A generalized transducing phage for the murine pathogen Citrobacter rodentium.
Microbiology (Reading, England) 2007;153(Pt 9):2984-8.
2007: Cooke Fiona J; Wain John; Fookes Maria; Ivens Alasdair; Thomson Nicholas; Brown Derek J; Threlfall E John; Gunn George; Foster Geoffrey; Dougan Gordon
Prophage sequences defining hot spots of genome variation in Salmonella enterica serovar Typhimurium can be used to discriminate between field isolates.
Journal of clinical microbiology 2007;45(8):2590-8.
2007: Dunstan Sarah J; Nguyen Thi Hue; Rockett Kirk; Forton Julian; Morris Andrew P; Diakite Mahamadou; Mai Ngoc Lanh; Le Thi Phuong; House Deborah; Parry Christopher M; Ha Vinh; Nguyen T Hieu; Dougan Gordon; Tran Tinh Hien; Kwiatowski Dominic; Farrar Jeremy J
A TNF region haplotype offers protection from typhoid fever in Vietnamese patients.
Human genetics 2007;122(1):51-61.
2007: Baker Stephen; Dougan Gordon
The genome of Salmonella enterica serovar Typhi.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2007;45 Suppl 1():S29-33.
2007: Coulthurst Sarah J; Clare Simon; Evans Terry J; Foulds Ian J; Roberts Kevin J; Welch Martin; Dougan Gordon; Salmond George P C
Quorum sensing has an unexpected role in virulence in the model pathogen Citrobacter rodentium.
EMBO reports 2007;8(7):698-703.
2007: Holt Kathryn E; Thomson Nicholas R; Wain John; Phan Minh Duy; Nair Satheesh; Hasan Rumina; Bhutta Zulfiqar A; Quail Michael A; Norbertczak Halina; Walker Danielle; Dougan Gordon; Parkhill Julian
Multidrug-resistant Salmonella enterica serovar paratyphi A harbors IncHI1 plasmids similar to those found in serovar typhi.
Journal of bacteriology 2007;189(11):4257-64.
2007: Baker Stephen; Hardy Jonathan; Sanderson Kenneth E; Quail Michael; Goodhead Ian; Kingsley Robert A; Parkhill Julian; Stocker Bruce; Dougan Gordon
A novel linear plasmid mediates flagellar variation in Salmonella Typhi.
PLoS pathogens 2007;3(5):e59.
2007: Khan S; Chatfield S; Stratford R; Bedwell J; Bentley M; Sulsh S; Giemza R; Smith S; Bongard E; Cosgrove C A; Johnson J; Dougan G; Griffin G E; Makin J; Lewis D J M
Ability of SPI2 mutant of S. typhi to effectively induce antibody responses to the mucosal antigen enterotoxigenic E. coli heat labile toxin B subunit after oral delivery to humans.
Vaccine 2007;25(21):4175-82.
2007: Low Walter; Mortlock Alison; Petrovska Liljana; Dottorini Tania; Dougan Gordon; Crisanti Andrea
Functional cell permeable motifs within medically relevant proteins.
Journal of biotechnology 2007;129(3):555-64.
2007: Rodriguez Antony; Vigorito Elena; Clare Simon; Warren Madhuri V; Couttet Philippe; Soond Dalya R; van Dongen Stijn; Grocock Russell J; Das Partha P; Miska Eric A; Vetrie David; Okkenhaug Klaus; Enright Anton J; Dougan Gordon; Turner Martin; Bradley Allan
Requirement of bic/microRNA-155 for normal immune function.
Science (New York, N.Y.) 2007;316(5824):608-11.
2007: Abd El Ghany Moataz; Jansen Angela; Clare Simon; Hall Lindsay; Pickard Derek; Kingsley Robert A; Dougan Gordon
Candidate live, attenuated Salmonella enterica serotype Typhimurium vaccines with reduced fecal shedding are immunogenic and effective oral vaccines.
Infection and immunity 2007;75(4):1835-42.
2007: van Diemen P M; Dziva F; Abu-Median A; Wallis T S; van den Bosch H; Dougan G; Chanter N; Frankel G; Stevens M P
Subunit vaccines based on intimin and Efa-1 polypeptides induce humoral immunity in cattle but do not protect against intestinal colonisation by enterohaemorrhagic Escherichia coli O157:H7 or O26:H-.
Veterinary immunology and immunopathology 2007;116(1-2):47-58.
2006: Thomson Nicholas R; Howard Sarah; Wren Brendan W; Holden Matthew T G; Crossman Lisa; Challis Gregory L; Churcher Carol; Mungall Karen; Brooks Karen; Chillingworth Tracey; Feltwell Theresa; Abdellah Zahra; Hauser Heidi; Jagels Kay; Maddison Mark; Moule Sharon; Sanders Mandy; Whitehead Sally; Quail Michael A; Dougan Gordon; Parkhill Julian; Prentice Michael B
The complete genome sequence and comparative genome analysis of the high pathogenicity Yersinia enterocolitica strain 8081.
PLoS genetics 2006;2(12):e206.
2006: Roumagnac Philippe; Weill François-Xavier; Dolecek Christiane; Baker Stephen; Brisse Sylvain; Chinh Nguyen Tran; Le Thi Anh Hong; Acosta Camilo J; Farrar Jeremy; Dougan Gordon; Achtman Mark
Evolutionary history of Salmonella typhi.
Science (New York, N.Y.) 2006;314(5803):1301-4.
2006: Jomaa Maha; Terry Stephen; Hale Chris; Jones Christopher; Dougan Gordon; Brown Jeremy
Immunization with the iron uptake ABC transporter proteins PiaA and PiuA prevents respiratory infection with Streptococcus pneumoniae.
Vaccine 2006;24(24):5133-9.
2006: Hale Christine; Bowe Frances; Pickard Derek; Clare Simon; Haeuw Jean-Francois; Powers Ultan; Menager Nathalie; Mastroeni Pietro; Dougan Gordon
Evaluation of a novel Vi conjugate vaccine in a murine model of salmonellosis.
Vaccine 2006;24(20):4312-20.
2006: Dougan Gordon; Hormaeche Carlos
How bacteria and their products provide clues to vaccine and adjuvant development.
Vaccine 2006;24 Suppl 2():S2-13-9.
2006: Cosgrove Catherine A; Castello-Branco Luiz R R; Hussell Tracy; Sexton Amy; Giemza Rafaela; Phillips Richard; Williams Andrew; Griffin George E; Dougan Gordon; Lewis David J M
Boosting of cellular immunity against Mycobacterium tuberculosis and modulation of skin cytokine responses in healthy human volunteers by Mycobacterium bovis BCG substrain Moreau Rio de Janeiro oral vaccine.
Infection and immunity 2006;74(4):2449-52.
2006: Malfitano Anna Maria; Cahill Rachel; Mitchell Peter; Frankel Gad; Dougan Gordon; Bifulco Maurizio; Lombardi Giovanna; Lechler Robert I; Bamford Kathleen B
Helicobacter pylori has stimulatory effects on naive T cells.
Helicobacter 2006;11(1):21-30.
2005: Mundy Rosanna; MacDonald Thomas T; Dougan Gordon; Frankel Gad; Wiles Siouxsie
Citrobacter rodentium of mice and man.
Cellular microbiology 2005;7(12):1697-706.
2005: Anjum Muna F; Marooney Chris; Fookes Maria; Baker Stephen; Dougan Gordon; Ivens Al; Woodward Martin J
Identification of core and variable components of the Salmonella enterica subspecies I genome by microarray.
Infection and immunity 2005;73(12):7894-905.
2005: Cahill R J; Tan S; Dougan G; O'Gaora P; Pickard D; Kennea N; Sullivan M H F; Feldman R G; Edwards A D
Universal DNA primers amplify bacterial DNA from human fetal membranes and link Fusobacterium nucleatum with prolonged preterm membrane rupture.
Molecular human reproduction 2005;11(10):761-6.
2005: Jomaa Maha; Yuste Jose; Paton James C; Jones Christopher; Dougan Gordon; Brown Jeremy S
Antibodies to the iron uptake ABC transporter lipoproteins PiaA and PiuA promote opsonophagocytosis of Streptococcus pneumoniae.
Infection and immunity 2005;73(10):6852-9.
2005: House Deborah; Chinh Nguyen T; Diep To S; Parry Christopher M; Wain John; Dougan Gordon; White Nicholas J; Hien Tran Tinh; Farrar Jeremy J
Use of paired serum samples for serodiagnosis of typhoid fever.
Journal of clinical microbiology 2005;43(9):4889-90.
2005: Baker Stephen; Sarwar Yasra; Aziz Hafsa; Haque Asma; Ali Aamir; Dougan Gordon; Wain John; Haque Abdul
Detection of Vi-negative Salmonella enterica serovar typhi in the peripheral blood of patients with typhoid fever in the Faisalabad region of Pakistan.
Journal of clinical microbiology 2005;43(9):4418-25.
2005: Wiles Siouxsie; Dougan Gordon; Frankel Gad
Emergence of a 'hyperinfectious' bacterial state after passage of Citrobacter rodentium through the host gastrointestinal tract.
Cellular microbiology 2005;7(8):1163-72.
2005: Bishop Anne L; Baker Stephen; Jenks Sara; Fookes Maria; Gaora Peadar O; Pickard Derek; Anjum Muna; Farrar Jeremy; Hien Tran T; Ivens Al; Dougan Gordon
Analysis of the hypervariable region of the Salmonella enterica genome associated with tRNA(leuX).
Journal of bacteriology 2005;187(7):2469-82.
2005: Tregoning John S; Clare Simon; Bowe Frances; Edwards Lorna; Fairweather Neil; Qazi Omar; Nixon Peter J; Maliga Pal; Dougan Gordon; Hussell Tracy
Protection against tetanus toxin using a plant-based vaccine.
European journal of immunology 2005;35(4):1320-6.
2005: Wain John; House Deborah; Zafar Afia; Baker Stephen; Nair Satheesh; Kidgell Claire; Bhutta Zulfiqar; Dougan Gordon; Hasan Rumina
Vi antigen expression in Salmonella enterica serovar Typhi clinical isolates from Pakistan.
Journal of clinical microbiology 2005;43(3):1158-65.
2005: Stratford Richard; McKelvie Nicola D; Hughes Nicky J; Aldred Emma; Wiseman Claire; Curtis Johanna; Bellaby Trevor; Bentley Matt; Hindle Zoë; Brennan Frank R; Chatfield Steven N; Dougan Gordon; Khan Shahid A
Optimization of Salmonella enterica serovar typhi DeltaaroC DeltassaV derivatives as vehicles for delivering heterologous antigens by chromosomal integration and in vivo inducible promoters.
Infection and immunity 2005;73(1):362-8.
2004: Petrovska Liljana; Aspinall Richard J; Barber Li; Clare Simon; Simmons Cameron P; Stratford Richard; Khan Shahid A; Lemoine Nicholas R; Frankel Gad; Holden David W; Dougan Gordon
Salmonella enterica serovar Typhimurium interaction with dendritic cells: impact of the sifA gene.
Cellular microbiology 2004;6(11):1071-84.
2004: Li Chris K F; Pender Sylvia L F; Pickard Karen M; Chance Victoria; Holloway Judith A; Huett Alan; Gonçalves Nathalie S; Mudgett John S; Dougan Gordon; Frankel Gad; MacDonald Thomas T
Impaired immunity to intestinal bacterial infection in stromelysin-1 (matrix metalloproteinase-3)-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(8):5171-9.
2004: Haque A; Bowe F; Fitzhenry R J; Frankel G; Thomson M; Heuschkel R; Murch S; Stevens M P; Wallis T S; Phillips A D; Dougan G
Early interactions of Salmonella enterica serovar typhimurium with human small intestinal epithelial explants.
Gut 2004;53(10):1424-30.
2004: Wiles Siouxsie; Clare Simon; Harker James; Huett Alan; Young Douglas; Dougan Gordon; Frankel Gad
Organ specificity, colonization and clearance dynamics in vivo following oral challenges with the murine pathogen Citrobacter rodentium.
Cellular microbiology 2004;6(10):963-72.
2004: Dahan Sivan; Knutton Stuart; Shaw Robert K; Crepin Valerie F; Dougan Gordon; Frankel Gad
Transcriptome of enterohemorrhagic Escherichia coli O157 adhering to eukaryotic plasma membranes.
Infection and immunity 2004;72(9):5452-9.
2004: Hale Christine; Humphreys Ian R; Hussell Tracy; Bowe Frances; Clare Simon; Pickard Derek; Preston Andrew; Del Giudice Giuseppe; Dougan Gordon
Mucosal immunisation of murine neonates using whole cell and acellular Pertussis vaccines.
Vaccine 2004;22(27-28):3595-602.
2004: McKelvie Nicola D; Stratford Richard; Wu Tao; Bellaby Trevor; Aldred Emma; Hughes Nicky J; Chatfield Steven N; Pickard Derek; Hale Christine; Dougan Gordon; Khan Shahid A
Expression of heterologous antigens in Salmonella Typhimurium vaccine vectors using the in vivo-inducible, SPI-2 promoter, ssaG.
Vaccine 2004;22(25-26):3243-55.
2004: Bowe Frances; Lavelle Ed C; McNeela Edel A; Hale Christine; Clare Simon; Arico Beatrice; Giuliani Marzia M; Rae Aaron; Huett Alan; Rappuoli Rino; Dougan Gordon; Mills Kingston H G
Mucosal vaccination against serogroup B meningococci: induction of bactericidal antibodies and cellular immunity following intranasal immunization with NadA of Neisseria meningitidis and mutants of Escherichia coli heat-labile enterotoxin.
Infection and immunity 2004;72(7):4052-60.
2004: Nguyen Quoc Chanh; Everest Paul; Tran Tan Khoa; House Deborah; Murch Simon; Parry Christopher; Connerton Phillippa; Phan Van Bay; To Song Diep; Mastroeni Pietro; White Nicholas J; Tran T Hien; Vo Van Ho; Dougan Gordon; Farrar Jeremy J; Wain John
A clinical, microbiological, and pathological study of intestinal perforation associated with typhoid fever.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2004;39(1):61-7.
2004: Thomson Nicholas; Baker Stephen; Pickard Derek; Fookes Maria; Anjum Muna; Hamlin Nancy; Wain John; House Deborah; Bhutta Zulfiqar; Chan Kaman; Falkow Stanley; Parkhill Julian; Woodward Martin; Ivens Al; Dougan Gordon
The role of prophage-like elements in the diversity of Salmonella enterica serovars.
Journal of molecular biology 2004;339(2):279-300.
2004: Tregoning John; Maliga Pal; Dougan Gordon; Nixon Peter J
New advances in the production of edible plant vaccines: chloroplast expression of a tetanus vaccine antigen, TetC.
Phytochemistry 2004;65(8):989-94.
2004: Mundy Rosanna; Petrovska Liljana; Smollett Katherine; Simpson Nandi; Wilson Rebecca K; Yu Jun; Tu Xuanlin; Rosenshine Ilan; Clare Simon; Dougan Gordon; Frankel Gad
Identification of a novel Citrobacter rodentium type III secreted protein, EspI, and roles of this and other secreted proteins in infection.
Infection and immunity 2004;72(4):2288-302.
2004: Norimatsu Mari; Chance Victoria; Dougan Gordon; Howard Christopher J; Villarreal-Ramos Bernardo
Live Salmonella enterica serovar Typhimurium (S. Typhimurium) elicit dendritic cell responses that differ from those induced by killed S. Typhimurium.
Veterinary immunology and immunopathology 2004;98(3-4):193-201.
2003: Clare Simon; Goldin Robert; Hale Christine; Aspinall Richard; Simmons Cameron; Mastroeni Pietro; Dougan Gordon
Intracellular adhesion molecule 1 plays a key role in acquired immunity to salmonellosis.
Infection and immunity 2003;71(10):5881-91.
2003: Wain John; Diem Nga L T; Kidgell Claire; James Keith; Fortune Sarah; Song Diep To; Ali Tahir; O Gaora Peadar; Parry Christopher; Parkhill Julian; Farrar Jeremy; White Nicholas J; Dougan Gordon
Molecular analysis of incHI1 antimicrobial resistance plasmids from Salmonella serovar Typhi strains associated with typhoid fever.
Antimicrobial agents and chemotherapy 2003;47(9):2732-9.
2003: Simmons Cameron P; Clare Simon; Ghaem-Maghami Marjan; Uren Tania K; Rankin Joanna; Huett Allan; Goldin Rob; Lewis David J; MacDonald Thomas T; Strugnell Richard A; Frankel Gad; Dougan Gordon
Central role for B lymphocytes and CD4+ T cells in immunity to infection by the attaching and effacing pathogen Citrobacter rodentium.
Infection and immunity 2003;71(9):5077-86.
2003: Pickard Derek; Wain John; Baker Stephen; Line Alexandra; Chohan Sonia; Fookes Maria; Barron Andrew; Gaora Peadar O; Chabalgoity José A; Thanky Niren; Scholes Christoph; Thomson Nicholas; Quail Michael; Parkhill Julian; Dougan Gordon
Composition, acquisition, and distribution of the Vi exopolysaccharide-encoding Salmonella enterica pathogenicity island SPI-7.
Journal of bacteriology 2003;185(17):5055-65.
2003: Humphreys Ian R; Edwards Lorna; Walzl Gerhard; Rae Aaron J; Dougan Gordon; Hill Sue; Hussell Tracy
OX40 ligation on activated T cells enhances the control of Cryptococcus neoformans and reduces pulmonary eosinophilia.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(12):6125-32.
2003: Gonçalves Nathalie S; Hale Christine; Dougan Gordon; Frankel Gad; MacDonald Thomas T
Binding of intimin from enteropathogenic Escherichia coli to lymphocytes and its functional consequences.
Infection and immunity 2003;71(5):2960-5.
2003: Mundy Rosanna; Pickard Derek; Wilson Rebecca K; Simmons Cameron P; Dougan Gordon; Frankel Gad
Identification of a novel type IV pilus gene cluster required for gastrointestinal colonization of Citrobacter rodentium.
Molecular microbiology 2003;48(3):795-809.
2003: MacDonald Thomas T; Frankel Gad; Dougan Gordon; Goncalves Nathalie S; Simmons Cameron
Host defences to Citrobacter rodentium.
International journal of medical microbiology : IJMM 2003;293(1):87-93.
2003: Neves Bianca C; Mundy Rosanna; Petrovska Liljana; Dougan Gordon; Knutton Stuart; Frankel Gad
CesD2 of enteropathogenic Escherichia coli is a second chaperone for the type III secretion translocator protein EspD.
Infection and immunity 2003;71(4):2130-41.
2003: Petrovska Liljana; Lopes Luciene; Simmons Cameron P; Pizza Mariagrazia; Dougan Gordon; Chain Benjamin M
Modulation of dendritic cell endocytosis and antigen processing pathways by Escherichia coli heat-labile enterotoxin and mutant derivatives.
Vaccine 2003;21(13-14):1445-54.
2003: Tregoning John S; Nixon Peter; Kuroda Hiroshi; Svab Zora; Clare Simon; Bowe Frances; Fairweather Neil; Ytterberg Jimmy; van Wijk Klaas J; Dougan Gordon; Maliga Pal
Expression of tetanus toxin Fragment C in tobacco chloroplasts.
Nucleic acids research 2003;31(4):1174-9.
2003: Kingsley Robert A; Humphries Andrea D; Weening Eric H; De Zoete Marcel R; Winter Sebastian; Papaconstantinopoulou Anastasia; Dougan Gordon; Bäumler Andreas J
Molecular and phenotypic analysis of the CS54 island of Salmonella enterica serotype typhimurium: identification of intestinal colonization and persistence determinants.
Infection and immunity 2003;71(2):629-40.
2003: Khan Shahid A; Stratford Richard; Wu Tao; Mckelvie Nicola; Bellaby Trevor; Hindle Zoe; Sinha Katharine A; Eltze Shayne; Mastroeni Piero; Pickard Derek; Dougan Gordon; Chatfield Steven N; Brennan Frank R
Salmonella typhi and S typhimurium derivatives harbouring deletions in aromatic biosynthesis and Salmonella Pathogenicity Island-2 (SPI-2) genes as vaccines and vectors.
Vaccine 2003;21(5-6):538-48.
2003: Norimatsu Mari; Harris James; Chance Victoria; Dougan Gordon; Howard Christopher J; Villarreal-Ramos Bernardo
Differential response of bovine monocyte-derived macrophages and dendritic cells to infection with Salmonella typhimurium in a low-dose model in vitro.
Immunology 2003;108(1):55-61.
2003: Bowe Frances; Pickard Derek J; Anderson Richard J; Londoño-Arcila Patricia; Dougan Gordon
Development of attenuated Salmonella strains that express heterologous antigens.
Methods in molecular medicine 2003;87():83-100.
2002: Chabalgoity José A; Dougan Gordon; Mastroeni Pietro; Aspinall Richard J
Live bacteria as the basis for immunotherapies against cancer.
Expert review of vaccines 2002;1(4):495-505.
2002: Reece Stephen; Simmons Cameron P; Fitzhenry Robert J; Ghaem-Maghami Marjan; Mundy Rosanna; Hale Christine; Matthews Stephen; Dougan Gordon; Phillips Alan D; Frankel Gad
Tyrosine residues at the immunoglobulin-C-type lectin inter-domain boundary of intimin are not involved in Tir-binding but implicated in colonisation of the host.
Microbes and infection / Institut Pasteur 2002;4(14):1389-99.
2002: Young Douglas; Hussell Tracy; Dougan Gordon
Chronic bacterial infections: living with unwanted guests.
Nature immunology 2002;3(11):1026-32.
2002: Kidgell Claire; Reichard Ulrike; Wain John; Linz Bodo; Torpdahl Mia; Dougan Gordon; Achtman Mark
Salmonella typhi, the causative agent of typhoid fever, is approximately 50,000 years old.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2002;2(1):39-45.
2002: Clare Simon; Huett Alan; Dougan Gordon
Host/pathogen interactions at mucosal surfaces: immune consequences.
Research in microbiology 2002;153(7):455-9.
2002: House Deborah; Chinh Nguyen T; Hien Tran T; Parry Christopher P; Ly Nguyen T; Diep To S; Wain John; Dunstan Sarah; White Nicholas J; Dougan Gordon; Farrar Jeremy J
Cytokine release by lipopolysaccharide-stimulated whole blood from patients with typhoid fever.
The Journal of infectious diseases 2002;186(2):240-5.
2002: Hindle Zoë; Chatfield Steven N; Phillimore Jo; Bentley Matthew; Johnson Julie; Cosgrove Catherine A; Ghaem-Maghami Marjan; Sexton Amy; Khan Mohammad; Brennan Frank R; Everest Paul; Wu Tao; Pickard Derek; Holden David W; Dougan Gordon; Griffin George E; House Deborah; Santangelo Joseph D; Khan Shahid A; Shea Jaqueline E; Feldman Robert G; Lewis David J M
Characterization of Salmonella enterica derivatives harboring defined aroC and Salmonella pathogenicity island 2 type III secretion system (ssaV) mutations by immunization of healthy volunteers.
Infection and immunity 2002;70(7):3457-67.
2002: Kidgell Claire; Pickard Derek; Wain John; James Keith; Diem Nga L T; Diep To Song; Levine Myron M; O'Gaora Peadar; Prentice Michael B; Parkhill Julian; Day Nicholas; Farrar Jeremy; Dougan Gordon
Characterisation and distribution of a cryptic Salmonella typhi plasmid pHCM2.
Plasmid 2002;47(3):159-71.
2002: Wain John; House Deborah; Parkhill Julian; Parry Christopher; Dougan Gordon
Unlocking the genome of the human typhoid bacillus.
The Lancet infectious diseases 2002;2(3):163-70.
2002: Reece Stephen; Simmons Cameron P; Fitzhenry Robert J; Batchelor Miranda; Hale Christine; Matthews Stephen; Phillips Alan D; Dougan Gordon; Frankel Gad
Mutagenesis of conserved tryptophan residues within the receptor-binding domain of intimin: influence on binding activity and virulence.
Microbiology (Reading, England) 2002;148(Pt 3):657-65.
2002: Simmons Cameron P; Goncalves Nathalie S; Ghaem-Maghami Marjan; Bajaj-Elliott Mona; Clare Simon; Neves Bianca; Frankel Gad; Dougan Gordon; MacDonald Thomas T
Impaired resistance and enhanced pathology during infection with a noninvasive, attaching-effacing enteric bacterial pathogen, Citrobacter rodentium, in mice lacking IL-12 or IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(4):1804-12.
2002: Warren Joanna; Mastroeni Pietro; Dougan Gordon; Noursadeghi Mahdad; Cohen Jonathan; Walport Mark J; Botto Marina
Increased susceptibility of C1q-deficient mice to Salmonella enterica serovar Typhimurium infection.
Infection and immunity 2002;70(2):551-7.
2002: Fitzhenry R J; Pickard D J; Hartland E L; Reece S; Dougan G; Phillips A D; Frankel G
Intimin type influences the site of human intestinal mucosal colonisation by enterohaemorrhagic Escherichia coli O157:H7.
Gut 2002;50(2):180-5.
2002: Dougan Gordon; Huett Alan; Clare Simon
Vaccines against human enteric bacterial pathogens.
British medical bulletin 2002;62():113-23.
2001: Stratford R; Douce G; Bowe F; Dougan G
A vaccination strategy incorporating DNA priming and mucosal boosting using tetanus toxin fragment C (TetC).
Vaccine 2001;20(3-4):516-25.
2001: Gonçalves N S; Ghaem-Maghami M; Monteleone G; Frankel G; Dougan G; Lewis D J; Simmons C P; MacDonald T T
Critical role for tumor necrosis factor alpha in controlling the number of lumenal pathogenic bacteria and immunopathology in infectious colitis.
Infection and immunity 2001;69(11):6651-9.
2001: House D; Bishop A; Parry C; Dougan G; Wain J
Typhoid fever: pathogenesis and disease.
Current opinion in infectious diseases 2001;14(5):573-8.
2001: Ghaem-Maghami M; Simmons C P; Daniell S; Pizza M; Lewis D; Frankel G; Dougan G
Intimin-specific immune responses prevent bacterial colonization by the attaching-effacing pathogen Citrobacter rodentium.
Infection and immunity 2001;69(9):5597-605.
2001: Wain J; House D; Pickard D; Dougan G; Frankel G
Acquisition of virulence-associated factors by the enteric pathogens Escherichia coli and Salmonella enterica.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2001;356(1411):1027-34.
2001: Everest P; Wain J; Roberts M; Rook G; Dougan G
The molecular mechanisms of severe typhoid fever.
Trends in microbiology 2001;9(7):316-20.
2001: Chiesa M D; Martensen P M; Simmons C; Porakishvili N; Justesen J; Dougan G; Roitt I M; Delves P J; Lund T
Refocusing of B-cell responses following a single amino acid substitution in an antigen.
Immunology 2001;103(2):172-8.
2001: Calabi E; Ward S; Wren B; Paxton T; Panico M; Morris H; Dell A; Dougan G; Fairweather N
Molecular characterization of the surface layer proteins from Clostridium difficile.
Molecular microbiology 2001;40(5):1187-99.
2001: Simmons C P; Clare S; Dougan G
Understanding mucosal responsiveness: lessons from enteric bacterial pathogens.
Seminars in immunology 2001;13(3):201-9.
2001: Frankel G; Phillips A D; Trabulsi L R; Knutton S; Dougan G; Matthews S
Intimin and the host cell--is it bound to end in Tir(s)?
Trends in microbiology 2001;9(5):214-8.
2001: Townsend S M; Kramer N E; Edwards R; Baker S; Hamlin N; Simmonds M; Stevens K; Maloy S; Parkhill J; Dougan G; Bäumler A J
Salmonella enterica serovar Typhi possesses a unique repertoire of fimbrial gene sequences.
Infection and immunity 2001;69(5):2894-901.
2001: Reece S; Simmons C P; Fitzhenry R J; Matthews S; Phillips A D; Dougan G; Frankel G
Site-directed mutagenesis of intimin alpha modulates intimin-mediated tissue tropism and host specificity.
Molecular microbiology 2001;40(1):86-98.
2001: Prentice M B; James K D; Parkhill J; Baker S G; Stevens K; Simmonds M N; Mungall K L; Churcher C; Oyston P C; Titball R W; Wren B W; Wain J; Pickard D; Hien T T; Farrar J J; Dougan G
Yersinia pestis pFra shows biovar-specific differences and recent common ancestry with a Salmonella enterica serovar Typhi plasmid.
Journal of bacteriology 2001;183(8):2586-94.
2001: Dunstan S J; Ho V A; Duc C M; Lanh M N; Phuong C X; Luxemburger C; Wain J; Dudbridge F; Peacock C S; House D; Parry C; Hien T T; Dougan G; Farrar J; Blackwell J M
Typhoid fever and genetic polymorphisms at the natural resistance-associated macrophage protein 1.
The Journal of infectious diseases 2001;183(7):1156-60.
2001: Pizza M; Giuliani M M; Fontana M R; Monaci E; Douce G; Dougan G; Mills K H; Rappuoli R; Del Giudice G
Mucosal vaccines: non toxic derivatives of LT and CT as mucosal adjuvants.
Vaccine 2001;19(17-19):2534-41.
2001: Simmons C P; Ghaem-Magami M; Petrovska L; Lopes L; Chain B M; Williams N A; Dougan G
Immunomodulation using bacterial enterotoxins.
Scandinavian journal of immunology 2001;53(3):218-26.
2001: Mastroeni P; Chabalgoity J A; Dunstan S J; Maskell D J; Dougan G
Salmonella: immune responses and vaccines.
Veterinary journal (London, England : 1997) 2001;161(2):132-64.
2001: House D; Wain J; Ho V A; Diep T S; Chinh N T; Bay P V; Vinh H; Duc M; Parry C M; Dougan G; White N J; Hien T T; Farrar J J
Serology of typhoid fever in an area of endemicity and its relevance to diagnosis.
Journal of clinical microbiology 2001;39(3):1002-7.
2001: Dougan G; Haque A; Pickard D; Frankel G; O'Goara P; Wain J
The Escherichia coli gene pool.
Current opinion in microbiology 2001;4(1):90-4.
2001: Khan S A; Strijbos P J; Everest P; Moss D; Stratford R; Mastroeni P; Allen J; Servos S; Charles I G; Dougan G; Maskell D J
Early responses to Salmonella typhimurium infection in mice occur at focal lesions in infected organs.
Microbial pathogenesis 2001;30(1):29-38.
2001: Simmons C P; Hussell T; Sparer T; Walzl G; Openshaw P; Dougan G
Mucosal delivery of a respiratory syncytial virus CTL peptide with enterotoxin-based adjuvants elicits protective, immunopathogenic, and immunoregulatory antiviral CD8+ T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(2):1106-13.
2001: Dunstan S J; Stephens H A; Blackwell J M; Duc C M; Lanh M N; Dudbridge F; Phuong C X; Luxemburger C; Wain J; Ho V A; Hien T T; Farrar J; Dougan G
Genes of the class II and class III major histocompatibility complex are associated with typhoid fever in Vietnam.
The Journal of infectious diseases 2001;183(2):261-268.
2000: Lopes L M; Maroof A; Dougan G; Chain B M
Inhibition of T-cell response by Escherichia coli heat-labile enterotoxin-treated epithelial cells.
Infection and immunity 2000;68(12):6891-5.
2000: Figueiredo D M; Matthews C C; Parks D A; Fairweather N F; Dougan G; Wilt S G; Fishman P S
Interaction of tetanus toxin derived hybrid proteins with neuronal cells.
Journal of natural toxins 2000;9(4):363-79.
2000: Stratford R; Douce G; Zhang-Barber L; Fairweather N; Eskola J; Dougan G
Influence of codon usage on the immunogenicity of a DNA vaccine against tetanus.
Vaccine 2000;19(7-8):810-5.
2000: Villarreal-Ramos B; Manser J M; Collins R A; Chance V; Eckersall D; Jones P W; Dougan G
Susceptibility of calves to challenge with Salmonella typhimurium 4/74 and derivatives harbouring mutations in htrA or purE.
Microbiology (Reading, England) 2000;146 ( Pt 11)():2775-83.
2000: Tacket C O; Galen J; Sztein M B; Losonsky G; Wyant T L; Nataro J; Wasserman S S; Edelman R; Chatfield S; Dougan G; Levine M M
Safety and immune responses to attenuated Salmonella enterica serovar typhi oral live vector vaccines expressing tetanus toxin fragment C.
Clinical immunology (Orlando, Fla.) 2000;97(2):146-53.
2000: Pizza M; Giuliani M M; Fontana M R; Douce G; Dougan G; Rappuoli R
LTK63 and LTR72, two mucosal adjuvants ready for clinical trials.
International journal of medical microbiology : IJMM 2000;290(4-5):455-61.
2000: Chabalgoity J A; Moreno M; Carol H; Dougan G; Hormaeche C E
Salmonella typhimurium as a basis for a live oral Echinococcus granulosus vaccine.
Vaccine 2000;19(4-5):460-9.
2000: Phillips A D; Navabpour S; Hicks S; Dougan G; Wallis T; Frankel G
Enterohaemorrhagic Escherichia coli O157:H7 target Peyer's patches in humans and cause attaching/effacing lesions in both human and bovine intestine.
Gut 2000;47(3):377-81.
2000: Soane M C; Jackson A; Maskell D; Allen A; Keig P; Dewar A; Dougan G; Wilson R
Interaction of Bordetella pertussis with human respiratory mucosa in vitro.
Respiratory medicine 2000;94(8):791-9.
2000: Hartland E L; Huter V; Higgins L M; Goncalves N S; Dougan G; Phillips A D; MacDonald T T; Frankel G
Expression of intimin gamma from enterohemorrhagic Escherichia coli in Citrobacter rodentium.
Infection and immunity 2000;68(8):4637-46.
2000: Mastroeni P; Vazquez-Torres A; Fang F C; Xu Y; Khan S; Hormaeche C E; Dougan G
Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. II. Effects on microbial proliferation and host survival in vivo.
The Journal of experimental medicine 2000;192(2):237-48.
2000: Massey R C; Bowe F; Sheehan B J; Dougan G; Dorman C J
The virulence plasmid of Salmonella typhimurium contains an autoregulated gene, rlgA, that codes for a resolvase-like DNA binding protein.
Plasmid 2000;44(1):24-33.
2000: Matthews C C; Figueiredo D M; Wollack J B; Fairweather N F; Dougan G; Hallewell R A; Cadet J L; Fishman P S
Protective effect of supplemental superoxide dismutase on survival of neuronal cells during starvation. Requirement for cytosolic distribution.
Journal of molecular neuroscience : MN 2000;14(3):155-66.
2000: Phillips A D; Giròn J; Hicks S; Dougan G; Frankel G
Intimin from enteropathogenic Escherichia coli mediates remodelling of the eukaryotic cell surface.
Microbiology (Reading, England) 2000;146 ( Pt 6)():1333-44.
2000: Batchelor M; Prasannan S; Daniell S; Reece S; Connerton I; Bloomberg G; Dougan G; Frankel G; Matthews S
Structural basis for recognition of the translocated intimin receptor (Tir) by intimin from enteropathogenic Escherichia coli.
The EMBO journal 2000;19(11):2452-64.
2000: Dougan G; Ghaem-Maghami M; Pickard D; Frankel G; Douce G; Clare S; Dunstan S; Simmons C
The immune responses to bacterial antigens encountered in vivo at mucosal surfaces.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2000;355(1397):705-12.
2000: Marshall D G; Bowe F; Hale C; Dougan G; Dorman C J
DNA topology and adaptation of Salmonella typhimurium to an intracellular environment.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2000;355(1397):565-74.
2000: Tacket C O; Sztein M B; Wasserman S S; Losonsky G; Kotloff K L; Wyant T L; Nataro J P; Edelman R; Perry J; Bedford P; Brown D; Chatfield S; Dougan G; Levine M M
Phase 2 clinical trial of attenuated Salmonella enterica serovar typhi oral live vector vaccine CVD 908-htrA in U.S. volunteers.
Infection and immunity 2000;68(3):1196-201.
2000: Sydenham M; Douce G; Bowe F; Ahmed S; Chatfield S; Dougan G
Salmonella enterica serovar typhimurium surA mutants are attenuated and effective live oral vaccines.
Infection and immunity 2000;68(3):1109-15.
2000: Connerton P; Wain J; Hien T T; Ali T; Parry C; Chinh N T; Vinh H; Ho V A; Diep T S; Day N P; White N J; Dougan G; Farrar J J
Epidemic typhoid in vietnam: molecular typing of multiple-antibiotic-resistant Salmonella enterica serotype typhi from four outbreaks.
Journal of clinical microbiology 2000;38(2):895-7.
2000: Londono L P; Jones H B; Vie A T; McPheat W L; Booth G; Gao X M; Dougan G
Characterisation of Candida albicans infections of haematogenous and mucosal origin in mice lacking the interferon gamma receptor protein.
FEMS immunology and medical microbiology 2000;27(2):117-25.
2000: Villarreal-Ramos B; Manser J M; Collins R A; Dougan G; Howard C J
Cattle immune responses to tetanus toxoid elicited by recombinant S. typhimurium vaccines or tetanus toxoid in alum or Freund's adjuvant.
Vaccine 2000;18(15):1515-21.
2000: Sanches M I; Keller R; Hartland E L; Figueiredo D M; Batchelor M; Martinez M B; Dougan G; Careiro-Sampaio M M; Frankel G; Trabulsi L R
Human colostrum and serum contain antibodies reactive to the intimin-binding region of the enteropathogenic Escherichia coli translocated intimin receptor.
Journal of pediatric gastroenterology and nutrition 2000;30(1):73-7.
2000: Jenkins C; Chart H; Smith H R; Hartland E L; Batchelor M; Delahay R M; Dougan G; Frankel G
Antibody response of patients infected with verocytotoxin-producing Escherichia coli to protein antigens encoded on the LEE locus.
Journal of medical microbiology 2000;49(1):97-101.
2000: Marshall D G; Haque A; Fowler R; Del Guidice G; Dorman C J; Dougan G; Bowe F
Use of the stationary phase inducible promoters, spv and dps, to drive heterologous antigen expression in Salmonella vaccine strains.
Vaccine 2000;18(14):1298-306.
2000: Mastroeni P; Simmons C; Fowler R; Hormaeche C E; Dougan G
Igh-6(-/-) (B-cell-deficient) mice fail to mount solid acquired resistance to oral challenge with virulent Salmonella enterica serovar typhimurium and show impaired Th1 T-cell responses to Salmonella antigens.
Infection and immunity 2000;68(1):46-53.
1999: Simmons C P; Mastroeni P; Fowler R; Ghaem-maghami M; Lycke N; Pizza M; Rappuoli R; Dougan G
MHC class I-restricted cytotoxic lymphocyte responses induced by enterotoxin-based mucosal adjuvants.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(12):6502-10.
1999: Batchelor M; Knutton S; Caprioli A; Huter V; Zanial M; Dougan G; Frankel G
Development of a universal intimin antiserum and PCR primers.
Journal of clinical microbiology 1999;37(12):3822-7.
1999: Rappuoli R; Pizza M; Douce G; Dougan G
Structure and mucosal adjuvanticity of cholera and Escherichia coli heat-labile enterotoxins.
Immunology today 1999;20(11):493-500.
1999: Mastroeni P; Bowe F; Cahill R; Simmons C; Dougan G
Vaccines against gut pathogens.
Gut 1999;45(5):633-5.
1999: Douce G; Giannelli V; Pizza M; Lewis D; Everest P; Rappuoli R; Dougan G
Genetically detoxified mutants of heat-labile toxin from Escherichia coli are able to act as oral adjuvants.
Infection and immunity 1999;67(9):4400-6.
1999: Wain J; Hien T T; Connerton P; Ali T; Parry C M; Chinh N T; Vinh H; Phuong C X; Ho V A; Diep T S; Farrar J J; White N J; Dougan G
Molecular typing of multiple-antibiotic-resistant Salmonella enterica serovar Typhi from Vietnam: application to acute and relapse cases of typhoid fever.
Journal of clinical microbiology 1999;37(8):2466-72.
1999: Everest P; Ketley J; Hardy S; Douce G; Khan S; Shea J; Holden D; Maskell D; Dougan G
Evaluation of Salmonella typhimurium mutants in a model of experimental gastroenteritis.
Infection and immunity 1999;67(6):2815-21.
1999: Hartland E L; Batchelor M; Delahay R M; Hale C; Matthews S; Dougan G; Knutton S; Connerton I; Frankel G
Binding of intimin from enteropathogenic Escherichia coli to Tir and to host cells.
Molecular microbiology 1999;32(1):151-8.
1999: Kelly G; Prasannan S; Daniell S; Fleming K; Frankel G; Dougan G; Connerton I; Matthews S
Structure of the cell-adhesion fragment of intimin from enteropathogenic Escherichia coli.
Nature structural biology 1999;6(4):313-8.
1999: Lowe D C; Savidge T C; Pickard D; Eckmann L; Kagnoff M F; Dougan G; Chatfield S N
Characterization of candidate live oral Salmonella typhi vaccine strains harboring defined mutations in aroA, aroC, and htrA.
Infection and immunity 1999;67(2):700-7.
1999: Mastroeni P; Clare S; Khan S; Harrison J A; Hormaeche C E; Okamura H; Kurimoto M; Dougan G
Interleukin 18 contributes to host resistance and gamma interferon production in mice infected with virulent Salmonella typhimurium.
Infection and immunity 1999;67(2):478-83.
1998: Frankel G; Phillips A D; Rosenshine I; Dougan G; Kaper J B; Knutton S
Enteropathogenic and enterohaemorrhagic Escherichia coli: more subversive elements.
Molecular microbiology 1998;30(5):911-21.
1998: Neves B C; Knutton S; Trabulsi L R; Sperandio V; Kaper J B; Dougan G; Frankel G
Molecular and ultrastructural characterisation of EspA from different enteropathogenic Escherichia coli serotypes.
FEMS microbiology letters 1998;169(1):73-80.
1998: Adu-Bobie J; Trabulsi L R; Carneiro-Sampaio M M; Dougan G; Frankel G
Identification of immunodominant regions within the C-terminal cell binding domain of intimin alpha and intimin beta from enteropathogenic Escherichia coli.
Infection and immunity 1998;66(12):5643-9.
1998: Mastroeni P; Harrison J A; Robinson J H; Clare S; Khan S; Maskell D J; Dougan G; Hormaeche C E
Interleukin-12 is required for control of the growth of attenuated aromatic-compound-dependent salmonellae in BALB/c mice: role of gamma interferon and macrophage activation.
Infection and immunity 1998;66(10):4767-76.
1998: Londoño P; Gao X M; Bowe F; McPheat W L; Booth G; Dougan G
Evaluation of the intranasal challenge route in mice as a mucosal model for Candida albicans infection.
Microbiology (Reading, England) 1998;144 ( Pt 8)():2291-8.
1998: Dorrell N; Li S R; Everest P H; Dougan G; Wren B W
Construction and characterisation of a Yersinia enterocolitica O:8 ompR mutant.
FEMS microbiology letters 1998;165(1):145-51.
1998: Loureiro I; Frankel G; Adu-Bobie J; Dougan G; Trabulsi L R; Carneiro-Sampaio M M
Human colostrum contains IgA antibodies reactive to enteropathogenic Escherichia coli virulence-associated proteins: intimin, BfpA, EspA, and EspB.
Journal of pediatric gastroenterology and nutrition 1998;27(2):166-71.
1998: Kelly G; Prasannan S; Daniell S; Frankel G; Dougan G; Connerton I; Matthews S
Sequential assignment of the triple labelled 30.1 kDa cell-adhesion domain of intimin from enteropathogenic E. coli.
Journal of biomolecular NMR 1998;12(1):189-91.
1998: Khan S A; Everest P; Servos S; Foxwell N; Zähringer U; Brade H; Rietschel E T; Dougan G; Charles I G; Maskell D J
A lethal role for lipid A in Salmonella infections.
Molecular microbiology 1998;29(2):571-9.
1998: Frankel G; Philips A D; Novakova M; Batchelor M; Hicks S; Dougan G
Generation of Escherichia coli intimin derivatives with differing biological activities using site-directed mutagenesis of the intimin C-terminus domain.
Molecular microbiology 1998;29(2):559-70.
1998: Douce G; Giuliani M M; Giannelli V; Pizza M G; Rappuoli R; Dougan G
Mucosal immunogenicity of genetically detoxified derivatives of heat labile toxin from Escherichia coli.
Vaccine 1998;16(11-12):1065-73.
1998: Everest P; Roberts M; Dougan G
Susceptibility to Salmonella typhimurium infection and effectiveness of vaccination in mice deficient in the tumor necrosis factor alpha p55 receptor.
Infection and immunity 1998;66(7):3355-64.
1998: Zhang-Barber L; Turner A K; Dougan G; Barrow P A
Protection of chickens against experimental fowl typhoid using a nuoG mutant of Salmonella serotype Gallinarum.
Vaccine 1998;16(9-10):899-903.
1998: Phillips A D; Trabulsi L R; Dougan G; Frankel G
Edwardsiella tarda induces plasma membrane ruffles on infection of HEp-2 cells.
FEMS microbiology letters 1998;161(2):317-23.
1998: Knutton S; Rosenshine I; Pallen M J; Nisan I; Neves B C; Bain C; Wolff C; Dougan G; Frankel G
A novel EspA-associated surface organelle of enteropathogenic Escherichia coli involved in protein translocation into epithelial cells.
The EMBO journal 1998;17(8):2166-76.
1998: Giuliani M M; Del Giudice G; Giannelli V; Dougan G; Douce G; Rappuoli R; Pizza M
Mucosal adjuvanticity and immunogenicity of LTR72, a novel mutant of Escherichia coli heat-labile enterotoxin with partial knockout of ADP-ribosyltransferase activity.
The Journal of experimental medicine 1998;187(7):1123-32.
1998: Hicks S; Frankel G; Kaper J B; Dougan G; Phillips A D
Role of intimin and bundle-forming pili in enteropathogenic Escherichia coli adhesion to pediatric intestinal tissue in vitro.
Infection and immunity 1998;66(4):1570-8.
1998: Adu-Bobie J; Frankel G; Bain C; Goncalves A G; Trabulsi L R; Douce G; Knutton S; Dougan G
Detection of intimins alpha, beta, gamma, and delta, four intimin derivatives expressed by attaching and effacing microbial pathogens.
Journal of clinical microbiology 1998;36(3):662-8.
1998: Xu D; McSorley S J; Tetley L; Chatfield S; Dougan G; Chan W L; Satoskar A; David J R; Liew F Y
Protective effect on Leishmania major infection of migration inhibitory factor, TNF-alpha, and IFN-gamma administered orally via attenuated Salmonella typhimurium.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(3):1285-9.
1998: Villarreal-Ramos B; Manser J; Collins R A; Dougan G; Chatfield S N; Howard C J
Immune responses in calves immunised orally or subcutaneously with a live Salmonella typhimurium aro vaccine.
Vaccine 1998;16(1):45-54.
1998: Marchetti M; Rossi M; Giannelli V; Giuliani M M; Pizza M; Censini S; Covacci A; Massari P; Pagliaccia C; Manetti R; Telford J L; Douce G; Dougan G; Rappuoli R; Ghiara P
Protection against Helicobacter pylori infection in mice by intragastric vaccination with H. pylori antigens is achieved using a non-toxic mutant of E. coli heat-labile enterotoxin (LT) as adjuvant.
Vaccine 1998;16(1):33-7.
1998: Donnenberg M S; Tacket C O; Losonsky G; Frankel G; Nataro J P; Dougan G; Levine M M
Effect of prior experimental human enteropathogenic Escherichia coli infection on illness following homologous and heterologous rechallenge.
Infection and immunity 1998;66(1):52-8.
1998: Everest P; Dougan G
Prospects of new vaccines for resurgent and emergent diseases.
British medical bulletin 1998;54(3):557-68.
1998: De Magistris M T; Pizza M; Douce G; Ghiara P; Dougan G; Rappuoli R
Adjuvant effect of non-toxic mutants of E. coli heat-labile enterotoxin following intranasal, oral and intravaginal immunization.
Developments in biological standardization 1998;92():123-6.
1997: Zhang-Barber L; Turner A K; Martin G; Frankel G; Dougan G; Barrow P A
Influence of genes encoding proton-translocating enzymes on suppression of Salmonella typhimurium growth and colonization.
Journal of bacteriology 1997;179(22):7186-90.
1997: Farrant J L; Sansone A; Canvin J R; Pallen M J; Langford P R; Wallis T S; Dougan G; Kroll J S
Bacterial copper- and zinc-cofactored superoxide dismutase contributes to the pathogenesis of systemic salmonellosis.
Molecular microbiology 1997;25(4):785-96.
1997: Everest P; Allen J; Papakonstantinopoulou A; Mastroeni P; Roberts M; Dougan G
Salmonella typhimurium infections in mice deficient in interleukin-4 production: role of IL-4 in infection-associated pathology.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(4):1820-7.
1997: Pallen M J; Dougan G; Frankel G
Coiled-coil domains in proteins secreted by type III secretion systems.
Molecular microbiology 1997;25(2):423-5.
1997: Douce G; Fontana M; Pizza M; Rappuoli R; Dougan G
Intranasal immunogenicity and adjuvanticity of site-directed mutant derivatives of cholera toxin.
Infection and immunity 1997;65(7):2821-8.
1997: Anderson R; Gao X M; Papakonstantinopoulou A; Fairweather N; Roberts M; Dougan G
Immunization of mice with DNA encoding fragment C of tetanus toxin.
Vaccine 1997;15(8):827-9.
1997: Figueiredo D M; Hallewell R A; Chen L L; Fairweather N F; Dougan G; Savitt J M; Parks D A; Fishman P S
Delivery of recombinant tetanus-superoxide dismutase proteins to central nervous system neurons by retrograde axonal transport.
Experimental neurology 1997;145(2 Pt 1):546-54.
1997: Knutton S; Adu-Bobie J; Bain C; Phillips A D; Dougan G; Frankel G
Down regulation of intimin expression during attaching and effacing enteropathogenic Escherichia coli adhesion.
Infection and immunity 1997;65(5):1644-52.
1997: Levine M M; Galen J; Barry E; Noriega F; Tacket C; Sztein M; Chatfield S; Dougan G; Losonsky G; Kotloff K
Attenuated Salmonella typhi and Shigella as live oral vaccines and as live vectors.
Behring Institute Mitteilungen 1997;(98):120-3.
1997: Tacket C O; Sztein M B; Losonsky G A; Wasserman S S; Nataro J P; Edelman R; Pickard D; Dougan G; Chatfield S N; Levine M M
Safety of live oral Salmonella typhi vaccine strains with deletions in htrA and aroC aroD and immune response in humans.
Infection and immunity 1997;65(2):452-6.
1996: Ali T; Papakonstantinopoulou A; Frankel G; Dougan G
Rapid mapping of cloned DNA fragments on the Salmonella chromosome.
BioTechniques 1996;21(6):1016-8, 1020, 1022.
1996: Frankel G; Phillips A D; Novakova M; Field H; Candy D C; Schauer D B; Douce G; Dougan G
Intimin from enteropathogenic Escherichia coli restores murine virulence to a Citrobacter rodentium eaeA mutant: induction of an immunoglobulin A response to intimin and EspB.
Infection and immunity 1996;64(12):5315-25.
1996: Everest P; Li J; Douce G; Charles I; De Azavedo J; Chatfield S; Dougan G; Roberts M
Role of the Bordetella pertussis P.69/pertactin protein and the P.69/pertactin RGD motif in the adherence to and invasion of mammalian cells.
Microbiology (Reading, England) 1996;142 ( Pt 11)():3261-8.
1996: Anderson R; Dougan G; Roberts M
Delivery of the Pertactin/P.69 polypeptide of Bordetella pertussis using an attenuated Salmonella typhimurium vaccine strain: expression levels and immune response.
Vaccine 1996;14(14):1384-90.
1996: Griffiths P L; Dougan G; Connerton I F
Transcription of the Campylobacter jejuni cell division gene ftsA.
FEMS microbiology letters 1996;143(1):83-7.
1996: Anderson R; Gao X M; Papakonstantinopoulou A; Roberts M; Dougan G
Immune response in mice following immunization with DNA encoding fragment C of tetanus toxin.
Infection and immunity 1996;64(8):3168-73.
1996: Frankel G; Lider O; Hershkoviz R; Mould A P; Kachalsky S G; Candy D C; Cahalon L; Humphries M J; Dougan G
The cell-binding domain of intimin from enteropathogenic Escherichia coli binds to beta1 integrins.
The Journal of biological chemistry 1996;271(34):20359-64.
1996: Frankel G; Phillips A D; Hicks S; Dougan G
Royal Society of Tropical Medicine and Hygiene meeting at Manson House, London, 14 December 1995. Enteropathogenic Escherichia coli--mucosal infection models.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1996;90(4):347-52.
1996: Gao X M; Wordsworth P; McMichael A J; Kyaw M M; Seifert M; Rees D; Dougan G
Homocysteine modification of HLA antigens and its immunological consequences.
European journal of immunology 1996;26(7):1443-50.
1996: Chacón M R; Londoño P; Dougan G; Selkirk M E
Heterologous expression of the cuticular-glutathione peroxidase of lymphatic filariae in an attenuated vaccine strain of Salmonella typhimurium abrogates H-2 restriction of specific antibody responses.
Parasite immunology 1996;18(6):307-16.
1996: Chambers M A; Dougan G; Newman J; Brown F; Crowther J; Mould A P; Humphries M J; Francis M J; Clarke B; Brown A L; Rowlands D
Chimeric hepatitis B virus core particles as probes for studying peptide-integrin interactions.
Journal of virology 1996;70(6):4045-52.
1996: Londoño L P; Chatfield S; Tindle R W; Herd K; Gao X M; Frazer I; Dougan G
Immunisation of mice using Salmonella typhimurium expressing human papillomavirus type 16 E7 epitopes inserted into hepatitis B virus core antigen.
Vaccine 1996;14(6):545-52.
1996: Di Tommaso A; Saletti G; Pizza M; Rappuoli R; Dougan G; Abrignani S; Douce G; De Magistris M T
Induction of antigen-specific antibodies in vaginal secretions by using a nontoxic mutant of heat-labile enterotoxin as a mucosal adjuvant.
Infection and immunity 1996;64(3):974-9.
1996: Levine M M; Galen J; Barry E; Noriega F; Chatfield S; Sztein M; Dougan G; Tacket C
Attenuated Salmonella as live oral vaccines against typhoid fever and as live vectors.
Journal of biotechnology 1996;44(1-3):193-6.
1996: Rappuoli R; Pizza M; Douce G; Dougan G
New vaccines against bacterial toxins.
Advances in experimental medicine and biology 1996;397():55-60.
1995: Frankel G; Gil S; Dougan G
Effect of deoxymannojirimycin and Brefeldin A on Yersinia pseudotuberculosis invasin--eukaryotic cell interaction.
Microbial pathogenesis 1995;19(6):421-7.
1995: Cropley I; Douce G; Roberts M; Chatfield S; Pizza M; Marsili I; Rappuoli R; Dougan G
Mucosal and systemic immunogenicity of a recombinant, non-ADP-ribosylating pertussis toxin: effects of formaldehyde treatment.
Vaccine 1995;13(17):1643-8.
1995: Ashton A C; Li Y; Doussau F; Weller U; Dougan G; Poulain B; Dolly J O
Tetanus toxin inhibits neuroexocytosis even when its Zn(2+)-dependent protease activity is removed.
The Journal of biological chemistry 1995;270(52):31386-90.
1995: Rappuoli R; Douce G; Dougan G; Pizza M
Genetic detoxification of bacterial toxins: a new approach to vaccine development.
International archives of allergy and immunology 1995;108(4):327-33.
1995: Frankel G; Candy D C; Fabiani E; Adu-Bobie J; Gil S; Novakova M; Phillips A D; Dougan G
Molecular characterization of a carboxy-terminal eukaryotic-cell-binding domain of intimin from enteropathogenic Escherichia coli.
Infection and immunity 1995;63(11):4323-8.
1995: Figueiredo D; Turcotte C; Frankel G; Li Y; Dolly O; Wilkin G; Marriott D; Fairweather N; Dougan G
Characterization of recombinant tetanus toxin derivatives suitable for vaccine development.
Infection and immunity 1995;63(8):3218-21.
1995: Roberts M; Bacon A; Rappuoli R; Pizza M; Cropley I; Douce G; Dougan G; Marinaro M; McGhee J; Chatfield S
A mutant pertussis toxin molecule that lacks ADP-ribosyltransferase activity, PT-9K/129G, is an effective mucosal adjuvant for intranasally delivered proteins.
Infection and immunity 1995;63(6):2100-8.
1995: Everest P; Griffiths P; Dougan G
Live Salmonella vaccines as a route towards oral immunisation.
Biologicals : journal of the International Association of Biological Standardization 1995;23(2):119-24.
1995: Lodge J; Douce G R; Amin I I; Bolton A J; Martin G D; Chatfield S; Dougan G; Brown N L; Stephen J
Biological and genetic characterization of TnphoA mutants of Salmonella typhimurium TML in the context of gastroenteritis.
Infection and immunity 1995;63(3):762-9.
1995: Everest P; Frankel G; Li J; Lund P; Chatfield S; Dougan G
Expression of LacZ from the htrA, nirB and groE promoters in a Salmonella vaccine strain: influence of growth in mammalian cells.
FEMS microbiology letters 1995;126(1):97-101.
1995: Douce G; Turcotte C; Cropley I; Roberts M; Pizza M; Domenghini M; Rappuoli R; Dougan G
Mutants of Escherichia coli heat-labile toxin lacking ADP-ribosyltransferase activity act as nontoxic, mucosal adjuvants.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(5):1644-8.
1995: Chatfield S N; Roberts M; Dougan G; Hormaeche C; Khan C M
The development of oral vaccines against parasitic diseases utilizing live attenuated Salmonella.
Parasitology 1995;110 Suppl():S17-24.
1994: Charles I; Fairweather N; Pickard D; Beesley J; Anderson R; Dougan G; Roberts M
Expression of the Bordetella pertussis P.69 pertactin adhesin in Escherichia coli: fate of the carboxy-terminal domain.
Microbiology (Reading, England) 1994;140 ( Pt 12)():3301-8.
1994: Khan C M; Villarreal-Ramos B; Pierce R J; Demarco de Hormaeche R; McNeill H; Ali T; Chatfield S; Capron A; Dougan G; Hormaeche C E
Construction, expression, and immunogenicity of multiple tandem copies of the Schistosoma mansoni peptide 115-131 of the P28 glutathione S-transferase expressed as C-terminal fusions to tetanus toxin fragment C in a live aro-attenuated vaccine strain of Salmonella.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(12):5634-42.
1994: Pickard D; Li J; Roberts M; Maskell D; Hone D; Levine M; Dougan G; Chatfield S
Characterization of defined ompR mutants of Salmonella typhi: ompR is involved in the regulation of Vi polysaccharide expression.
Infection and immunity 1994;62(9):3984-93.
1994: Harrison J A; Pickard D; Higgins C F; Khan A; Chatfield S N; Ali T; Dorman C J; Hormaeche C E; Dougan G
Role of hns in the virulence phenotype of pathogenic salmonellae.
Molecular microbiology 1994;13(1):133-40.
1994: Li Y; Foran P; Fairweather N F; de Paiva A; Weller U; Dougan G; Dolly J O
A single mutation in the recombinant light chain of tetanus toxin abolishes its proteolytic activity and removes the toxicity seen after reconstitution with native heavy chain.
Biochemistry 1994;33(22):7014-20.
1994: Frankel G; Candy D C; Everest P; Dougan G
Characterization of the C-terminal domains of intimin-like proteins of enteropathogenic and enterohemorrhagic Escherichia coli, Citrobacter freundii, and Hafnia alvei.
Infection and immunity 1994;62(5):1835-42.
1994: Tindle R W; Herd K; Londoño P; Fernando G J; Chatfield S N; Malcolm K; Dougan G
Chimeric hepatitis B core antigen particles containing B- and Th-epitopes of human papillomavirus type 16 E7 protein induce specific antibody and T-helper responses in immunised mice.
Virology 1994;200(2):547-57.
1994: Dougan G
1993 Colworth Prize Lecture. The molecular basis for the virulence of bacterial pathogens: implications for oral vaccine development.
Microbiology (Reading, England) 1994;140 ( Pt 2)():215-24.
1994: Chatfield S; Roberts M; Li J; Starns A; Dougan G
The use of live attenuated Salmonella for oral vaccination.
Developments in biological standardization 1994;82():35-42.
1993: Maskell D; Frankel G; Dougan G
Phase and antigenic variation--the impact on strategies for bacterial vaccine design.
Trends in biotechnology 1993;11(12):506-10.
1993: Chamberlain L M; Strugnell R; Dougan G; Hormaeche C E; Demarco de Hormaeche R
Neisseria gonorrhoeae strain MS11 harbouring a mutation in gene aroA is attenuated and immunogenic.
Microbial pathogenesis 1993;15(1):51-63.
1993: Chatfield S; Roberts M; Londono P; Cropley I; Douce G; Dougan G
The development of oral vaccines based on live attenuated Salmonella strains.
FEMS immunology and medical microbiology 1993;7(1):1-7.
1993: Roberts M; Cropley I; Chatfield S; Dougan G
Protection of mice against respiratory Bordetella pertussis infection by intranasal immunization with P.69 and FHA.
Vaccine 1993;11(8):866-72.
1992: Strugnell R; Dougan G; Chatfield S; Charles I; Fairweather N; Tite J; Li J L; Beesley J; Roberts M
Characterization of a Salmonella typhimurium aro vaccine strain expressing the P.69 antigen of Bordetella pertussis.
Infection and immunity 1992;60(10):3994-4002.
1992: Moore J D; Lamb H K; Garbe T; Servos S; Dougan G; Charles I G; Hawkins A R
Inducible overproduction of the Aspergillus nidulans pentafunctional AROM protein and the type-I and -II 3-dehydroquinases from Salmonella typhi and Mycobacterium tuberculosis.
The Biochemical journal 1992;287 ( Pt 1)():173-81.
1992: Li J; Fairweather N F; Novotny P; Dougan G; Charles I G
Cloning, nucleotide sequence and heterologous expression of the protective outer-membrane protein P.68 pertactin from Bordetella bronchiseptica.
Journal of general microbiology 1992;138 Pt 8():1697-705.
1992: Chatfield S N; Charles I G; Makoff A J; Oxer M D; Dougan G; Pickard D; Slater D; Fairweather N F
Use of the nirB promoter to direct the stable expression of heterologous antigens in Salmonella oral vaccine strains: development of a single-dose oral tetanus vaccine.
Bio/technology (Nature Publishing Company) 1992;10(8):888-92.
1992: Carrier M J; Chatfield S N; Dougan G; Nowicka U T; O'Callaghan D; Beesley J E; Milano S; Cillari E; Liew F Y
Expression of human IL-1 beta in Salmonella typhimurium. A model system for the delivery of recombinant therapeutic proteins in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(4):1176-81.
1992: Chatfield S N; Strahan K; Pickard D; Charles I G; Hormaeche C E; Dougan G
Evaluation of Salmonella typhimurium strains harbouring defined mutations in htrA and aroA in the murine salmonellosis model.
Microbial pathogenesis 1992;12(2):145-51.
1992: Roberts M; Tite J P; Fairweather N F; Dougan G; Charles I G
Recombinant P.69/pertactin: immunogenicity and protection of mice against Bordetella pertussis infection.
Vaccine 1992;10(1):43-8.
1992: Chatfield S N; Fairweather N; Charles I; Pickard D; Levine M; Hone D; Posada M; Strugnell R A; Dougan G
Construction of a genetically defined Salmonella typhi Ty2 aroA, aroC mutant for the engineering of a candidate oral typhoid-tetanus vaccine.
Vaccine 1992;10(1):53-60.
1991: Romanos M A; Clare J J; Beesley K M; Rayment F B; Ballantine S P; Makoff A J; Dougan G; Fairweather N F; Charles I G
Recombinant Bordetella pertussis pertactin (P69) from the yeast Pichia pastoris: high-level production and immunological properties.
Vaccine 1991;9(12):901-6.
1991: Tite J P; Dougan G; Chatfield S N
The involvement of tumor necrosis factor in immunity to Salmonella infection.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(9):3161-4.
1991: Hone D M; Harris A M; Chatfield S; Dougan G; Levine M M
Construction of genetically defined double aro mutants of Salmonella typhi.
Vaccine 1991;9(11):810-6.
1991: Garbe T; Servos S; Hawkins A; Dimitriadis G; Young D; Dougan G; Charles I
The Mycobacterium tuberculosis shikimate pathway genes: evolutionary relationship between biosynthetic and catabolic 3-dehydroquinases.
Molecular & general genetics : MGG 1991;228(3):385-92.
1991: Comerford S A; McCance D J; Dougan G; Tite J P
Identification of T- and B-cell epitopes of the E7 protein of human papillomavirus type 16.
Journal of virology 1991;65(9):4681-90.
1991: Roberts M; Fairweather N F; Leininger E; Pickard D; Hewlett E L; Robinson A; Hayward C; Dougan G; Charles I G
Construction and characterization of Bordetella pertussis mutants lacking the vir-regulated P.69 outer membrane protein.
Molecular microbiology 1991;5(6):1393-404.
1991: Lipscombe M; Charles I G; Roberts M; Dougan G; Tite J; Fairweather N F
Intranasal immunization using the B subunit of the Escherichia coli heat-labile toxin fused to an epitope of the Bordetella pertussis P.69 antigen.
Molecular microbiology 1991;5(6):1385-92.
1991: Charles I G; Li J L; Roberts M; Beesley K; Romanos M; Pickard D J; Francis M; Campbell D; Dougan G; Brennan M J
Identification and characterization of a protective immunodominant B cell epitope of pertactin (P.69) from Bordetella pertussis.
European journal of immunology 1991;21(5):1147-53.
1991: Li L J; Dougan G; Novotny P; Charles I G
P.70 pertactin, an outer-membrane protein from Bordetella parapertussis: cloning, nucleotide sequence and surface expression in Escherichia coli.
Molecular microbiology 1991;5(2):409-17.
1991: Johnson K; Charles I; Dougan G; Pickard D; O'Gaora P; Costa G; Ali T; Miller I; Hormaeche C
The role of a stress-response protein in Salmonella typhimurium virulence.
Molecular microbiology 1991;5(2):401-7.
1991: Servos S; Chatfield S; Hone D; Levine M; Dimitriadis G; Pickard D; Dougan G; Fairweather N; Charles I
Molecular cloning and characterization of the aroD gene encoding 3-dehydroquinase from Salmonella typhi.
Journal of general microbiology 1991;137(1):147-52.
1991: Servos S; Silva C; Dougan G; Charles I G
The commercially available restriction enzyme BspHI is blocked by overlapping methylation.
Nucleic acids research 1991;19(1):183.
1991: Chatfield S N; Dorman C J; Hayward C; Dougan G
Role of ompR-dependent genes in Salmonella typhimurium virulence: mutants deficient in both ompC and ompF are attenuated in vivo.
Infection and immunity 1991;59(1):449-52.
1990: Garbe T; Jones C; Charles I; Dougan G; Young D
Cloning and characterization of the aroA gene from Mycobacterium tuberculosis.
Journal of bacteriology 1990;172(12):6774-82.
1990: Chatfield S; Dougan G; Charles I
Complete nucleotide sequence of the aroA gene from Salmonella typhi encoding 5-enolpyruvylshikimate 3-phosphate synthase.
Nucleic acids research 1990;18(20):6133.
1990: Tite J P; Hughes-Jenkins C; O'Callaghan D; Dougan G; Russell S M; Gao X M; Liew F Y
Anti-viral immunity induced by recombinant nucleoprotein of influenza A virus. II. Protection from influenza infection and mechanism of protection.
Immunology 1990;71(2):202-7.
1990: Dougan G; Chatfield S; Roberts M; Charles I; Comerford S; Li L J; Fairweather N
Bacterial pathogens--a route to oral drug delivery.
Biochemical Society transactions 1990;18(5):746-8.
1990: Fairweather N F; Chatfield S N; Charles I G; Roberts M; Lipscombe M; Li L J; Strugnell D; Comerford S; Tite J; Dougan G
Use of live attenuated bacteria to stimulate immunity.
Research in microbiology 1990;141(7-8):769-73.
1990: Johnson K S; Charles I G; Dougan G; Miller I A; Pickard D; O'Goara P; Costa G; Ali T; Hormaeche C E
The role of a stress-response protein in bacterial virulence.
Research in microbiology 1990;141(7-8):823-5.
1990: O'Gaora P; Roberts M; Bowe F; Hormaeche C; Demarco de Hormaeche R; Cafferkey M; Tite J; Dougan G
Yersinia enterocolitica aroA mutants as carriers of the B subunit of the Escherichia coli heat-labile enterotoxin to the murine immune system.
Microbial pathogenesis 1990;9(2):105-16.
1990: Tite J P; Gao X M; Hughes-Jenkins C M; Lipscombe M; O'Callaghan D; Dougan G; Liew F Y
Anti-viral immunity induced by recombinant nucleoprotein of influenza A virus. III. Delivery of recombinant nucleoprotein to the immune system using attenuated Salmonella typhimurium as a live carrier.
Immunology 1990;70(4):540-6.
1990: Fairweather N F; Chatfield S N; Makoff A J; Strugnell R A; Bester J; Maskell D J; Dougan G
Oral vaccination of mice against tetanus by use of a live attenuated Salmonella carrier.
Infection and immunity 1990;58(5):1323-6.
1990: Charles I; Dougan G
Gene expression and the development of live enteric vaccines.
Trends in biotechnology 1990;8(5):117-21.
1990: Roberts M; Maskell D; Novotny P; Dougan G
Construction and characterization in vivo of Bordetella pertussis aroA mutants.
Infection and immunity 1990;58(3):732-9.
1990: Strugnell R A; Maskell D; Fairweather N; Pickard D; Cockayne A; Penn C; Dougan G
Stable expression of foreign antigens from the chromosome of Salmonella typhimurium vaccine strains.
Gene 1990;88(1):57-63.
1990: Charles I G; Lamb H K; Pickard D; Dougan G; Hawkins A R
Isolation, characterization and nucleotide sequences of the aroC genes encoding chorismate synthase from Salmonella typhi and Escherichia coli.
Journal of general microbiology 1990;136(2):353-8.
1990: O'Callaghan D; Maskell D; Tite J; Dougan G
Immune responses in BALB/c mice following immunization with aromatic compound or purine-dependent Salmonella typhimurium strains.
Immunology 1990;69(2):184-9.
1989: O'Gaora P; Maskel D; Coleman D; Cafferkey M; Dougan G
Cloning and characterisation of the serC and aroA genes of Yersinia enterocolitica, and construction of an aroA mutant.
Gene 1989;84(1):23-30.
1989: Chatfield S N; Strugnell R A; Dougan G
Live Salmonella as vaccines and carriers of foreign antigenic determinants.
Vaccine 1989;7(6):495-8.
1989: Bowe F; O'Gaora P; Maskell D; Cafferkey M; Dougan G
Virulence, persistence, and immunogenicity of Yersinia enterocolitica O:8 aroA mutants.
Infection and immunity 1989;57(10):3234-6.
1989: Miller I; Maskell D; Hormaeche C; Johnson K; Pickard D; Dougan G
Isolation of orally attenuated Salmonella typhimurium following TnphoA mutagenesis.
Infection and immunity 1989;57(9):2758-63.
1989: Dougan G
Molecular characterization of bacterial virulence factors and the consequences for vaccine design. The 1988 Fleming lecture.
Journal of general microbiology 1989;135(6):1397-406.
1989: Charles I G; Dougan G; Pickard D; Chatfield S; Smith M; Novotny P; Morrissey P; Fairweather N F
Molecular cloning and characterization of protective outer membrane protein P.69 from Bordetella pertussis.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(10):3554-8.
1989: Leslie D; Fairweather N; Pickard D; Dougan G; Kehoe M
Phospholipase C and haemolytic activities of Clostridium perfringens alpha-toxin cloned in Escherichia coli: sequence and homology with a Bacillus cereus phospholipase C.
Molecular microbiology 1989;3(3):383-92.
1989: Miller I A; Chatfield S; Dougan G; Desilva L; Joysey H S; Hormaeche C
Bacteriophage P22 as a vehicle for transducing cosmid gene banks between smooth strains of Salmonella typhimurium: use in identifying a role for aroD in attenuating virulent Salmonella strains.
Molecular & general genetics : MGG 1989;215(2):312-6.
1988: Tite J P; Russell S M; Dougan G; O'Callaghan D; Jones I; Brownlee G; Liew F Y
Antiviral immunity induced by recombinant nucleoprotein of influenza A virus. I. Characteristics and cross-reactivity of T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(11):3980-7.
1988: Dougan G; Chatfield S; Pickard D; Bester J; O'Callaghan D; Maskell D
Construction and characterization of vaccine strains of Salmonella harboring mutations in two different aro genes.
The Journal of infectious diseases 1988;158(6):1329-35.
1988: Maskell D J; Morrissey P; Dougan G
Cloning and nucleotide sequence of the aroA gene of Bordetella pertussis.
Journal of bacteriology 1988;170(6):2467-71.
1988: Chatfield S N; Fernie D S; Penn C; Dougan G
Identification of the major antigens of Treponema hyodysenteriae and comparison with those of Treponema innocens.
Infection and immunity 1988;56(5):1070-5.
1988: O'Callaghan D; Maskell D; Liew F Y; Easmon C S; Dougan G
Characterization of aromatic- and purine-dependent Salmonella typhimurium: attention, persistence, and ability to induce protective immunity in BALB/c mice.
Infection and immunity 1988;56(2):419-23.
1988: Dougan G; Maskell D; O'Callaghan D; Chatfield S; Charles I; Hormaeche C
Oral vaccination.
Antonie van Leeuwenhoek 1988;54(5):447-51.
1988: Charles I G; Dougan G; Pickard D; Charfield S; Smith M; Novotny P; Fairweather N
Molecular cloning and analysis of P. 69, a vir-controlled protein from Bordetella pertussis.
The Tokai journal of experimental and clinical medicine 1988;13 Suppl():227-34.
1987: Dougan G; Maskell D; Pickard D; Hormaeche C
Isolation of stable aroA mutants of Salmonella typhi Ty2: properties and preliminary characterisation in mice.
Molecular & general genetics : MGG 1987;207(2-3):402-5.
1987: Maskell D J; Sweeney K J; O'Callaghan D; Hormaeche C E; Liew F Y; Dougan G
Salmonella typhimurium aroA mutants as carriers of the Escherichia coli heat-labile enterotoxin B subunit to the murine secretory and systemic immune systems.
Microbial pathogenesis 1987;2(3):211-21.
1987: Brown A; Hormaeche C E; Demarco de Hormaeche R; Winther M; Dougan G; Maskell D J; Stocker B A
An attenuated aroA Salmonella typhimurium vaccine elicits humoral and cellular immunity to cloned beta-galactosidase in mice.
The Journal of infectious diseases 1987;155(1):86-92.
1986: Maskell D; Sweeney K; O'Callaghan D; Liew F Y; Fairweather N; Dougan G
Attenuated salmonellae as vaccines and carriers of foreign antigens.
Annali Sclavo. Collana monografica 1986;3(1-2):133-41.

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