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Dennis Dougherty

Research Profile

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TOP 3
Dennis A Dougherty
The Cation-π Interaction.
Walrati Limapichat; Wesley Y Yu; Emma Branigan; Henry A Lester; Dennis A Dougherty
Key Binding Interactions for Memantine in the NMDA Receptor.
Jamie A Ashby; Netta Cohen; Federico Comitani; Dennis A Dougherty; Ian V McGonigle; Carla Molteni; Kerry L Price; Sarah C R Lummis
GABA binding to an insect GABA receptor: a molecular dynamics and mutagenesis study.

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All Publications

2013: Dennis A Dougherty
The Cation-π Interaction.
Accounts of chemical research 2013;46(4):885-93.
2013: Walrati Limapichat; Wesley Y Yu; Emma Branigan; Henry A Lester; Dennis A Dougherty
Key Binding Interactions for Memantine in the NMDA Receptor.
ACS chemical neuroscience 2013;4(2):255-60.
2012: Jamie A Ashby; Netta Cohen; Federico Comitani; Dennis A Dougherty; Ian V McGonigle; Carla Molteni; Kerry L Price; Sarah C R Lummis
GABA binding to an insect GABA receptor: a molecular dynamics and mutagenesis study.
Biophysical journal 2012;103(10):2071-81.
2012: Kristina N-M Daeffler; Henry A Lester; Dennis A Dougherty
Functionally important aromatic-aromatic and sulfur-π interactions in the D2 dopamine receptor.
Journal of the American Chemical Society 2012;134(36):14890-6.
2012: Ximena Da Silva Tavares; Angela P Blum; Henry A Lester; Darren T Nakamura; Nyssa L Puskar; Jai A P Shanata; Dennis A Dougherty
Variations in binding among several agonists at two stoichiometries of the neuronal, α4β2 nicotinic receptor.
Journal of the American Chemical Society 2012;134(28):11474-80.
2012: Christopher I Richards; Rahul Srinivasan; Stephen W Turner; Dennis A Dougherty; Jonas Korlach; Khai Luong; Henry A Lester
Live-cell imaging of single receptor composition using zero-mode waveguide nanostructures.
Nano letters 2012;12(7):3690-4.
2012: Rahul Srinivasan; Cheng Xiao; Dennis A Dougherty; Julie M Miwa; Rigo Pantoja; Doreen Rhee; Christopher I Richards; Henry A Lester
Pharmacological chaperoning of nicotinic acetylcholine receptors reduces the endoplasmic reticulum stress response.
Molecular pharmacology 2012;81(6):759-69.
2012: Nyssa L Puskar; Henry A Lester; Dennis A Dougherty
Probing the effects of residues located outside the agonist binding site on drug-receptor selectivity in the nicotinic receptor.
ACS chemical biology 2012;7(5):841-6.
2012: Rahul Srinivasan; Crystal Dilworth; Dennis A Dougherty; Fraser J Moss; Christopher I Richards; Henry A Lester
Förster Resonance Energy Transfer (FRET) Correlates of Altered Subunit Stoichiometry in Cys-Loop Receptors, Exemplified by Nicotinic α4β2.
International journal of molecular sciences 2012;13(8):10022-40.
2012: Jai A P Shanata; Shawnalea J Frazier; Henry A Lester; Dennis A Dougherty
Using mutant cycle analysis to elucidate long-range functional coupling in allosteric receptors.
Methods in molecular biology (Clifton, N.J.) 2012;796():97-113.
2011: Ethan B Van Arnam; Henry A Lester; Dennis A Dougherty
Dissecting the functions of conserved prolines within transmembrane helices of the D2 dopamine receptor.
ACS chemical biology 2011;6(10):1063-8.
2011: Sarah C R Lummis; Ian McGonigle; Jamie A Ashby; Dennis A Dougherty
Two amino acid residues contribute to a cation-π binding interaction in the binding site of an insect GABA receptor.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(34):12371-6.
2010: Sean M A Kedrowski; Dennis A Dougherty
Room-temperature alternative to the Arbuzov reaction: the reductive deoxygenation of acyl phosphonates.
Organic letters 2010;12(18):3990-3.
2010: Noah H Duffy; Dennis A Dougherty
Preparation of translationally competent tRNA by direct chemical acylation.
Organic letters 2010;12(17):3776-9.
2010: Angela P Blum; Henry A Lester; Dennis A Dougherty
Nicotinic pharmacophore: the pyridine N of nicotine and carbonyl of acetylcholine hydrogen bond across a subunit interface to a backbone NH.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(30):13206-11.
2009: Amy L Eastwood; Angela P Blum; Niki M Zacharias; Dennis A Dougherty
A selenide-based approach to photochemical cleavage of peptide and protein backbones at engineered backbone esters.
The Journal of organic chemistry 2009;74(23):9241-4.
2009: Michael M Torrice; Kiowa S Bower; Henry A Lester; Dennis A Dougherty
Probing the role of the cation-pi interaction in the binding sites of GPCRs using unnatural amino acids.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(29):11919-24.
2009: Kristin R Gleitsman; Henry A Lester; Dennis A Dougherty
Probing the role of backbone hydrogen bonding in a critical beta sheet of the extracellular domain of a cys-loop receptor.
Chembiochem : a European journal of chemical biology 2009;10(8):1385-91.
2009: Kristin R Gleitsman; Jai A P Shanata; Shawnalea J Frazier; Henry A Lester; Dennis A Dougherty
Long-range coupling in an allosteric receptor revealed by mutant cycle analysis.
Biophysical journal 2009;96(8):3168-78.
2009: Xinan Xiu; Nyssa L Puskar; Jai A P Shanata; Henry A Lester; Dennis A Dougherty
Nicotine binding to brain receptors requires a strong cation-pi interaction.
Nature 2009;458(7237):534-7.
2009: Henry A Lester; Cheng Xiao; Rahul Srinivasan; Cagdas Son; Julie Miwa; Rigo Pantoja; Matthew R Banghart; Dennis A Dougherty; Alison Goate; Jen C Wang
Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery.
The AAPS journal 2009;11(1):167-77.
2009: Rigo Pantoja; Erik A Rodriguez; Mohammed I Dibas; Dennis A Dougherty; Henry A Lester
Single-molecule imaging of a fluorescent unnatural amino acid incorporated into nicotinic receptors.
Biophysical journal 2009;96(1):226-37.
2008: Ariele P Hanek; Henry A Lester; Dennis A Dougherty
A stereochemical test of a proposed structural feature of the nicotinic acetylcholine receptor.
Journal of the American Chemical Society 2008;130(40):13216-8.
2008: Kerry L Price; Kiowa S Bower; Andrew J Thompson; Henry A Lester; Dennis A Dougherty; Sarah C R Lummis
A hydrogen bond in loop A is critical for the binding and function of the 5-HT3 receptor.
Biochemistry 2008;47(24):6370-7.
2008: Dennis A Dougherty
Physical organic chemistry on the brain.
The Journal of organic chemistry 2008;73(10):3667-73.
2008: Dennis A Dougherty
Cys-loop neuroreceptors: structure to the rescue?
Chemical reviews 2008;108(5):1642-53.
2008: Kiowa S Bower; Kerry L Price; Laura E C Sturdee; Mariza Dayrell; Dennis A Dougherty; Sarah C R Lummis
5-Fluorotryptamine is a partial agonist at 5-HT3 receptors, and reveals that size and electronegativity at the 5 position of tryptamine are critical for efficient receptor function.
European journal of pharmacology 2008;580(3):291-7.
2007: Erik A Rodriguez; Henry A Lester; Dennis A Dougherty
Improved amber and opal suppressor tRNAs for incorporation of unnatural amino acids in vivo. Part 1: minimizing misacylation.
RNA (New York, N.Y.) 2007;13(10):1703-14.
2007: Erik A Rodriguez; Henry A Lester; Dennis A Dougherty
Improved amber and opal suppressor tRNAs for incorporation of unnatural amino acids in vivo. Part 2: evaluating suppression efficiency.
RNA (New York, N.Y.) 2007;13(10):1715-22.
2007: Jinti Wang; Henry A Lester; Dennis A Dougherty
Establishing an ion pair interaction in the homomeric rho1 gamma-aminobutyric acid type A receptor that contributes to the gating pathway.
The Journal of biological chemistry 2007;282(36):26210-6.
2007: Sean M A Kedrowski; Kiowa S Bower; Dennis A Dougherty
1-Oxo-5-hydroxytryptamine: a surprisingly potent agonist of the 5-HT3 (serotonin) receptor.
Organic letters 2007;9(17):3205-7.
2007: Dennis A Dougherty
Cation-pi interactions involving aromatic amino acids.
The Journal of nutrition 2007;137(6 Suppl 1):1504S-1508S; discussion 1516S-1517S.
2007: Joshua A Maurer; Victor E White; Dennis A Dougherty; Jay L Nadeau
Reconstitution of ion channels in agarose-supported silicon orifices.
Biosensors & bioelectronics 2007;22(11):2577-84.
2007: Claire L Padgett; Ariele P Hanek; Henry A Lester; Dennis A Dougherty; Sarah C R Lummis
Unnatural amino acid mutagenesis of the GABA(A) receptor binding site residues reveals a novel cation-pi interaction between GABA and beta 2Tyr97.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(4):886-92.
2007: Amanda L Cashin; Michael M Torrice; Kathryn A McMenimen; Henry A Lester; Dennis A Dougherty
Chemical-scale studies on the role of a conserved aspartate in preorganizing the agonist binding site of the nicotinic acetylcholine receptor.
Biochemistry 2007;46(3):630-9.
2006: Erik A Rodriguez; Henry A Lester; Dennis A Dougherty
In vivo incorporation of multiple unnatural amino acids through nonsense and frameshift suppression.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(23):8650-5.
2006: Kathryn A McMenimen; Dennis A Dougherty; Henry A Lester; E James Petersson
Probing the Mg2+ blockade site of an N-methyl-D-aspartate (NMDA) receptor with unnatural amino acid mutagenesis.
ACS chemical biology 2006;1(4):227-34.
2006: Steven A Spronk; Donald E Elmore; Dennis A Dougherty
Voltage-dependent hydration and conduction properties of the hydrophobic pore of the mechanosensitive channel of small conductance.
Biophysical journal 2006;90(10):3555-69.
2005: Xinan Xiu; Ariele P Hanek; Jinti Wang; Henry A Lester; Dennis A Dougherty
A unified view of the role of electrostatic interactions in modulating the gating of Cys loop receptors.
The Journal of biological chemistry 2005;280(50):41655-66.
2005: Sarah C R Lummis; Darren L Beene; Lori W Lee; Henry A Lester; R William Broadhurst; Dennis A Dougherty
Cis-trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel.
Nature 2005;438(7065):248-52.
2005: Sarah C R Lummis; Darren L Beene; Neil J Harrison; Henry A Lester; Dennis A Dougherty
A cation-pi binding interaction with a tyrosine in the binding site of the GABAC receptor.
Chemistry & biology 2005;12(9):993-7.
2005: Deborah M Rothman; E James Petersson; M. Eugenio Vázquez; Gabriel S Brandt; Dennis A Dougherty; Barbara Imperiali
Caged phosphoproteins.
Journal of the American Chemical Society 2005;127(3):846-7.
2005: Amanda L Cashin; E James Petersson; Henry A Lester; Dennis A Dougherty
Using physical chemistry to differentiate nicotinic from cholinergic agonists at the nicotinic acetylcholine receptor.
Journal of the American Chemical Society 2005;127(1):350-6.
2004: Darren L Beene; Kerry L Price; Henry A Lester; Dennis A Dougherty; Sarah C R Lummis
Tyrosine residues that control binding and gating in the 5-hydroxytryptamine3 receptor revealed by unnatural amino acid mutagenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(41):9097-104.
2004: David S Dahan; Mohammed I Dibas; E James Petersson; Vincent C Auyeung; Baron Chanda; Francisco Bezanilla; Dennis A Dougherty; Henry A Lester
A fluorophore attached to nicotinic acetylcholine receptor beta M2 detects productive binding of agonist to the alpha delta site.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(27):10195-200.
2004: Henry A Lester; Mohammed I Dibas; David S Dahan; John F Leite; Dennis A Dougherty
Cys-loop receptors: new twists and turns.
Trends in neurosciences 2004;27(6):329-36.
2004: Daniel Clayton; George Shapovalov; Joshua A Maurer; Dennis A Dougherty; Henry A Lester; Gerd G Kochendoerfer
Total chemical synthesis and electrophysiological characterization of mechanosensitive channels from Escherichia coli and Mycobacterium tuberculosis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(14):4764-9.
2003: John F Leite; Michael P Blanton; Mona Shahgholi; Dennis A Dougherty; Henry A Lester
Conformation-dependent hydrophobic photolabeling of the nicotinic receptor: electrophysiology-coordinated photochemistry and mass spectrometry.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(22):13054-9.
2003: Donald E Elmore; Dennis A Dougherty
Investigating lipid composition effects on the mechanosensitive channel of large conductance (MscL) using molecular dynamics simulations.
Biophysical journal 2003;85(3):1512-24.
2003: Ting-Wei Mu; Henry A Lester; Dennis A Dougherty
Different binding orientations for the same agonist at homologous receptors: a lock and key or a simple wedge?
Journal of the American Chemical Society 2003;125(23):6850-1.
2003: Joshua A Maurer; Dennis A Dougherty
Generation and evaluation of a large mutational library from the Escherichia coli mechanosensitive channel of large conductance, MscL: implications for channel gating and evolutionary design.
The Journal of biological chemistry 2003;278(23):21076-82.
2003: Darren L Beene; Dennis A Dougherty; Henry A Lester
Unnatural amino acid mutagenesis in mapping ion channel function.
Current opinion in neurobiology 2003;13(3):264-70.
2003: Sarah L Monahan; Henry A Lester; Dennis A Dougherty
Site-specific incorporation of unnatural amino acids into receptors expressed in Mammalian cells.
Chemistry & biology 2003;10(6):573-80.
2003: John F Leite; Dennis A Dougherty; Henry A Lester; Mona Shahgholi
Investigation of apparent mass deviations in electrospray ionization tandem mass spectrometry of a benzophenone-labeled peptide.
Rapid communications in mass spectrometry : RCM 2003;17(15):1677-84.
2003: E James Petersson; Gabriel S Brandt; Niki M Zacharias; Dennis A Dougherty; Henry A Lester
Caging proteins through unnatural amino acid mutagenesis.
Methods in enzymology 2003;360():258-73.
2002: E James Petersson; Anita Choi; David S Dahan; Henry A Lester; Dennis A Dougherty
A perturbed pK(a) at the binding site of the nicotinic acetylcholine receptor: implications for nicotine binding.
Journal of the American Chemical Society 2002;124(43):12662-3.
2002: Darren L Beene; Gabriel S Brandt; Wenge Zhong; Niki M Zacharias; Henry A Lester; Dennis A Dougherty
Cation-pi interactions in ligand recognition by serotonergic (5-HT3A) and nicotinic acetylcholine receptors: the anomalous binding properties of nicotine.
Biochemistry 2002;41(32):10262-9.
2002: Niki M Zacharias; Dennis A Dougherty
Cation-pi interactions in ligand recognition and catalysis.
Trends in pharmacological sciences 2002;23(6):281-7.
2002: E James Petersson; Mona Shahgholi; Henry A Lester; Dennis A Dougherty
MALDI-TOF mass spectrometry methods for evaluation of in vitro aminoacyl tRNA production.
RNA (New York, N.Y.) 2002;8(4):542-7.
2001: Joshua A Maurer; Dennis A Dougherty
A high-throughput screen for MscL channel activity and mutational phenotyping.
Biochimica et biophysica acta 2001;1514(2):165-9.
2001: Donald E Elmore; Dennis A Dougherty
Molecular dynamics simulations of wild-type and mutant forms of the Mycobacterium tuberculosis MscL channel.
Biophysical journal 2001;81(3):1345-59.
2001: K D Philipson; JP Gallivan; Gabriel S Brandt; Dennis A Dougherty; Henry A Lester
Incorporation of caged cysteine and caged tyrosine into a transmembrane segment of the nicotinic ACh receptor.
American journal of physiology. Cell physiology 2001;281(1):C195-206.
2001: Y Tong; Gabriel S Brandt; Ming Li; George Shapovalov; Eric M Slimko; A Karschin; Dennis A Dougherty; Henry A Lester
Tyrosine decaging leads to substantial membrane trafficking during modulation of an inward rectifier potassium channel.
The Journal of general physiology 2001;117(2):103-18.
2001: L Li; W Zhong; Niki M Zacharias; C Gibbs; Henry A Lester; Dennis A Dougherty
The tethered agonist approach to mapping ion channel proteins--toward a structural model for the agonist binding site of the nicotinic acetylcholine receptor.
Chemistry & biology 2001;8(1):47-58.
2000: Joshua A Maurer; Donald E Elmore; Henry A Lester; Dennis A Dougherty
Comparing and contrasting Escherichia coli and Mycobacterium tuberculosis mechanosensitive channels (MscL). New gain of function mutations in the loop region.
The Journal of biological chemistry 2000;275(29):22238-44.
2000: H Dang; Pam M England; S S Farivar; Dennis A Dougherty; Henry A Lester
Probing the role of a conserved M1 proline residue in 5-hydroxytryptamine(3) receptor gating.
Molecular pharmacology 2000;57(6):1114-22.
2000: Donald E Elmore; Dennis A Dougherty
A computational study of nicotine conformations in the gas phase and in water.
The Journal of organic chemistry 2000;65(3):742-7.
1999: Pam M England; Henry A Lester; Dennis A Dougherty
Mapping disulfide connectivity using backbone ester hydrolysis.
Biochemistry 1999;38(43):14409-15.
1999: JP Gallivan; Dennis A Dougherty
Cation-pi interactions in structural biology.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(17):9459-64.
1999: JP Gallivan; Dennis A Dougherty
Can lone pairs bind to a pi system? The water...hexafluorobenzene interaction.
Organic letters 1999;1(1):103-5.
1999: Pam M England; Y Zhang; Dennis A Dougherty; Henry A Lester
Backbone mutations in transmembrane domains of a ligand-gated ion channel: implications for the mechanism of gating.
Cell 1999;96(1):89-98.
1998: W Zhong; JP Gallivan; Yan Zhang; L Li; Henry A Lester; Dennis A Dougherty
From ab initio quantum mechanics to molecular neurobiology: a cation-pi binding site in the nicotinic receptor.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(21):12088-93.
1998: SK Silverman; Henry A Lester; Dennis A Dougherty
Asymmetrical contributions of subunit pore regions to ion selectivity in an inward rectifier K+ channel.
Biophysical journal 1998;75(3):1330-9.
1998: J C Miller; SK Silverman; Pam M England; Dennis A Dougherty; Henry A Lester
Flash decaging of tyrosine sidechains in an ion channel.
Neuron 1998;20(4):619-24.
1998: Henry A Lester; Dennis A Dougherty
New views of multi-ion channels.
The Journal of general physiology 1998;111(2):181-3.
1998: Mark W Nowak; JP Gallivan; SK Silverman; Cesar Labarca; Dennis A Dougherty; Henry A Lester
In vivo incorporation of unnatural amino acids into ion channels in Xenopus oocyte expression system.
Methods in enzymology 1998;293():504-29.
1998: Dennis A Dougherty
Stereochemical issues in studies of ion channel proteins.
Chirality 1998;10(1-2):8-13.
1997: Anthony P West; Pamela J Bjorkman; Dennis A Dougherty; Henry A Lester
Expression and circular dichroism studies of the extracellular domain of the alpha subunit of the nicotinic acetylcholine receptor.
The Journal of biological chemistry 1997;272(41):25468-73.
1997: JP Gallivan; Henry A Lester; Dennis A Dougherty
Site-specific incorporation of biotinylated amino acids to identify surface-exposed residues in integral membrane proteins.
Chemistry & biology 1997;4(10):739-49.
1997: Pam M England; Henry A Lester; Norman Davidson; Dennis A Dougherty
Site-specific, photochemical proteolysis applied to ion channels in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(20):11025-30.
1996: S K Silverman; P Kofuji; Dennis A Dougherty; Norman Davidson; Henry A Lester
A regenerative link in the ionic fluxes through the weaver potassium channel underlies the pathophysiology of the mutation.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(26):15429-34.
1996: P C Kearney; H Zhang; W Zhong; Dennis A Dougherty; Henry A Lester
Determinants of nicotinic receptor gating in natural and unnatural side chain structures at the M2 9' position.
Neuron 1996;17(6):1221-9.
1996: S K Silverman; Henry A Lester; Dennis A Dougherty
Subunit stoichiometry of a heteromultimeric G protein-coupled inward-rectifier K+ channel.
The Journal of biological chemistry 1996;271(48):30524-8.
1996: P C Kearney; M W Nowak; W Zhong; S K Silverman; Henry A Lester; Dennis A Dougherty
Dose-response relations for unnatural amino acids at the agonist binding site of the nicotinic acetylcholine receptor: tests with novel side chains and with several agonists.
Molecular pharmacology 1996;50(5):1401-12.
1996: S Mecozzi; Anthony P West; Dennis A Dougherty
Cation-pi interactions in aromatics of biological and medicinal interest: electrostatic potential surfaces as a useful qualitative guide.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(20):10566-71.
1996: M E Saks; J R Sampson; M W Nowak; P C Kearney; F Du; John Abelson; Henry A Lester; Dennis A Dougherty
An engineered Tetrahymena tRNAGln for in vivo incorporation of unnatural amino acids into proteins by nonsense suppression.
The Journal of biological chemistry 1996;271(38):23169-75.
1996: Dennis A Dougherty
Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp.
Science (New York, N.Y.) 1996;271(5246):163-8.
1993: R A Kumpf; Dennis A Dougherty
A mechanism for ion selectivity in potassium channels: computational studies of cation-pi interactions.
Science (New York, N.Y.) 1993;261(5129):1708-10.
1990: Dennis A Dougherty; D A Stauffer
Acetylcholine binding by a synthetic receptor: implications for biological recognition.
Science (New York, N.Y.) 1990;250(4987):1558-60.