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Steven Dower

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Publications

TOP 3
Ward Jon R; Francis Sheila E; Marsden Luke; Suddason Tesha; Lord Graham M; Dower Steven K; Crossman David C; Sabroe Ian
A central role for monocytes in Toll-like receptor-mediated activation of the vasculature.
Eder Katalin; Guan Hongtao; Sung Hye Y; Ward Jon; Angyal Adrienn; Janas Michelle; Sarmay Gabriella; Duda Erno; Turner Martin; Dower Steven K; Francis Sheila E; Crossman David C; Kiss-Toth Endre
Tribbles-2 is a novel regulator of inflammatory activation of monocytes.
Sabroe I; Parker L C; Calverley P M A; Dower S K; Whyte M K B
Pathological networking: a new approach to understanding COPD.

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All Publications

2009: Ward Jon R; Francis Sheila E; Marsden Luke; Suddason Tesha; Lord Graham M; Dower Steven K; Crossman David C; Sabroe Ian
A central role for monocytes in Toll-like receptor-mediated activation of the vasculature.
Immunology 2009;128(1):58-68.
2008: Eder Katalin; Guan Hongtao; Sung Hye Y; Ward Jon; Angyal Adrienn; Janas Michelle; Sarmay Gabriella; Duda Erno; Turner Martin; Dower Steven K; Francis Sheila E; Crossman David C; Kiss-Toth Endre
Tribbles-2 is a novel regulator of inflammatory activation of monocytes.
International immunology 2008;20(12):1543-50.
2008: Sabroe I; Parker L C; Calverley P M A; Dower S K; Whyte M K B
Pathological networking: a new approach to understanding COPD.
Postgraduate medical journal 2008;84(991):259-64.
2008: Guan Hongtao; Kiss-Toth Endre; Dower Steven K
Analysis of innate immune signal transduction with autocatalytic expression vectors.
Journal of immunological methods 2008;330(1-2):96-108.
2007: Sabroe Ian; Parker Lisa C; Dower Steven K; Whyte Moira K B
Practical and conceptual models of chronic obstructive pulmonary disease.
Proceedings of the American Thoracic Society 2007;4(8):606-10.
2007: Sabroe Ian; Parker Lisa C; Calverley Peter M A; Dower Steven K; Whyte Moira K B
Pathological networking: a new approach to understanding COPD.
Thorax 2007;62(8):733-8.
2007: Sung Hye Youn; Guan Hongtao; Czibula Agnes; King Andrea R; Eder Katalin; Heath Emily; Suvarna S Kim; Dower Steven K; Wilson Anthony G; Francis Sheila E; Crossman David C; Kiss-Toth Endre
Human tribbles-1 controls proliferation and chemotaxis of smooth muscle cells via MAPK signaling pathways.
The Journal of biological chemistry 2007;282(25):18379-87.
2007: Wilson H L; Varcoe R W; Stokes L; Holland K L; Francis S E; Dower S K; Surprenant A; Crossman D C
P2X receptor characterization and IL-1/IL-1Ra release from human endothelial cells.
British journal of pharmacology 2007;151(1):115-27.
2007: Sabroe Ian; Parker Lisa C; Dockrell David H; Davies Donna E; Dower Steven K; Whyte Moira K B
Targeting the networks that underpin contiguous immunity in asthma and chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 2007;175(4):306-11.
2007: Sabroe Ian; Dockrell David H; Vogel Stefanie N; Renshaw Stephen A; Whyte Moira K B; Dower Steven K
Identifying and hurdling obstacles to translational research.
Nature reviews. Immunology 2007;7(1):77-82.
2007: Moore Lisa J; Gilbey Andrea M; Dowson Christopher G; Pridmore Alison C; Dower Steven K; Read Robert C
Proinflammatory activation of Toll-like receptor-2 during exposure of penicillin-resistant Streptococcus pneumoniae to beta-lactam antibiotics.
The Journal of antimicrobial chemotherapy 2007;59(1):35-42.
2007: Dower Steven K; Qwarnstrom Eva E; Kiss-Toth Endre
Fluorescent protein reporter systems for single-cell measurements.
Methods in molecular biology (Clifton, N.J.) 2007;411():111-9.
2006: Guan Hongtao; Holland Karen; Qwarnstrom Eva; Dower Steven K; Kiss-Toth Endre
Feedback loops in intracellular signal processing and their potential for identifying novel signalling proteins.
Cellular immunology 2006;244(2):158-61.
2006: Morris Gavin E; Parker Lisa C; Ward Jon R; Jones Elizabeth C; Whyte Moira K B; Brightling Christopher E; Bradding Peter; Dower Steven K; Sabroe Ian
Cooperative molecular and cellular networks regulate Toll-like receptor-dependent inflammatory responses.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(12):2153-5.
2006: Chamberlain Janet; Evans David; King Andrea; Dewberry Rachael; Dower Steven; Crossman David; Francis Sheila
Interleukin-1beta and signaling of interleukin-1 in vascular wall and circulating cells modulates the extent of neointima formation in mice.
The American journal of pathology 2006;168(4):1396-403.
2006: Evans Iona; Dower Steven K; Francis Sheila E; Crossman David C; Wilson Heather L
Action of intracellular IL-1Ra (Type 1) is independent of the IL-1 intracellular signalling pathway.
Cytokine 2006;33(5):274-80.
2006: Ward Jon R; Dower Steven K; Whyte Moira K B; Buttle David J; Sabroe Ian
Potentiation of TLR4 signalling by plasmin activity.
Biochemical and biophysical research communications 2006;341(2):299-303.
2006: Kiss-Toth Endre; Wyllie David H; Holland Karen; Marsden Luke; Jozsa Veronika; Oxley Kevin M; Polgar Timea; Qwarnstrom Eva E; Dower Steven K
Functional mapping and identification of novel regulators for the Toll/Interleukin-1 signalling network by transcription expression cloning.
Cellular signalling 2006;18(2):202-14.
2005: Kiss-Toth E; Wyllie D H; Holland K; Marsden L; Jozsa V; Oxley K M; Polgar T; Qwarnstrom E E; Dower S K
Functional mapping of Toll/interleukin-1 signalling networks by expression cloning.
Biochemical Society transactions 2005;33(Pt 6):1405-6.
2005: Parker Lisa C; Jones Elizabeth C; Prince Lynne R; Dower Steven K; Whyte Moira K B; Sabroe Ian
Endotoxin tolerance induces selective alterations in neutrophil function.
Journal of leukocyte biology 2005;78(6):1301-5.
2005: Morton Allison C; Arnold Nadine D; Gunn Julian; Varcoe Richard; Francis Sheila E; Dower Steven K; Crossman David C
Interleukin-1 receptor antagonist alters the response to vessel wall injury in a porcine coronary artery model.
Cardiovascular research 2005;68(3):493-501.
2005: Sabroe Ian; Dower Steven K; Whyte Moira K B
The role of Toll-like receptors in the regulation of neutrophil migration, activation, and apoptosis.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2005;41 Suppl 7():S421-6.
2005: Ward Jon R; Bingle Lynne; Judge Heather M; Brown Simon B; Storey Robert F; Whyte Moira K B; Dower Steven K; Buttle David J; Sabroe Ian
Agonists of toll-like receptor (TLR)2 and TLR4 are unable to modulate platelet activation by adenosine diphosphate and platelet activating factor.
Thrombosis and haemostasis 2005;94(4):831-8.
2005: Chaudhuri Nazia; Dower Steven K; Whyte Moira K B; Sabroe Ian
Toll-like receptors and chronic lung disease.
Clinical science (London, England : 1979) 2005;109(2):125-33.
2005: Telekes András; Kiss-Tóth Endre; Nagy Tünde; Qwarnstrom Eva E; Kúsz Erzsébet; Polgár Timea; Resetár Akos; Dower Steven K; Duda Erno
Synergistic effect of Avemar on proinflammatory cytokine production and Ras-mediated cell activation.
Annals of the New York Academy of Sciences 2005;1051():515-28.
2005: Parker Lisa C; Whyte Moira K B; Dower Steven K; Sabroe Ian
The expression and roles of Toll-like receptors in the biology of the human neutrophil.
Journal of leukocyte biology 2005;77(6):886-92.
2005: Sabroe Ian; Jones Elizabeth C; Whyte Moira K B; Dower Steven K
Regulation of human neutrophil chemokine receptor expression and function by activation of Toll-like receptors 2 and 4.
Immunology 2005;115(1):90-8.
2005: Morris Gavin E; Whyte Moira K B; Martin Gillian F; Jose Peter J; Dower Steven K; Sabroe Ian
Agonists of toll-like receptors 2 and 4 activate airway smooth muscle via mononuclear leukocytes.
American journal of respiratory and critical care medicine 2005;171(8):814-22.
2004: Prince Lynne R; Allen Lucy; Jones Elizabeth C; Hellewell Paul G; Dower Steven K; Whyte Moira K B; Sabroe Ian
The role of interleukin-1beta in direct and toll-like receptor 4-mediated neutrophil activation and survival.
The American journal of pathology 2004;165(5):1819-26.
2004: Kiss-Toth Endre; Bagstaff Stephanie M; Sung Hye Y; Jozsa Veronika; Dempsey Clare; Caunt Jim C; Oxley Kevin M; Wyllie David H; Polgar Timea; Harte Mary; O'neill Luke A J; Qwarnstrom Eva E; Dower Steven K
Human tribbles, a protein family controlling mitogen-activated protein kinase cascades.
The Journal of biological chemistry 2004;279(41):42703-8.
2004: Wilson Heather L; Francis Sheila E; Dower Steven K; Crossman David C
Secretion of intracellular IL-1 receptor antagonist (type 1) is dependent on P2X7 receptor activation.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(2):1202-8.
2004: Moore Lisa J; Pridmore Alison C; Dower Steven K; Read Robert C
The glycopeptide vancomycin does not enhance toll-like receptor 2 (TLR2) activation by Streptococcus pneumoniae.
The Journal of antimicrobial chemotherapy 2004;54(1):76-8.
2004: Sabroe I; Prince L R; Dower S K; Walmsley S R; Chilvers E R; Whyte M K B
What can we learn from highly purified neutrophils?
Biochemical Society transactions 2004;32(Pt3):468-9.
2004: Kiss-Toth Endre; Qwarnstrom Eva E; Dower Steven K
Hunting for genes by functional screens.
Cytokine & growth factor reviews 2004;15(2-3):97-102.
2004: Parker Lisa C; Whyte Moira K B; Vogel Stefanie N; Dower Steven K; Sabroe Ian
Toll-like receptor (TLR)2 and TLR4 agonists regulate CCR expression in human monocytic cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(8):4977-86.
2004: Renshaw Stephen A; Dempsey Clare E; Barnes Frances A; Bagstaff Stephanie M; Dower Steven K; Bingle Colin D; Whyte Moira K B
Three novel Bid proteins generated by alternative splicing of the human Bid gene.
The Journal of biological chemistry 2004;279(4):2846-55.
2003: Dower S K; Qwarnstrom E E
Signalling networks, inflammation and innate immunity.
Biochemical Society transactions 2003;31(Pt 6):1462-71.
2003: Lawrie Allan; Brisken Axel F; Francis Sheila E; Wyllie David; Kiss-Toth Endre; Qwarnstrom Eva E; Dower Stephen K; Crossman David C; Newman Christopher M
Ultrasound-enhanced transgene expression in vascular cells is not dependent upon cavitation-induced free radicals.
Ultrasound in medicine & biology 2003;29(10):1453-61.
2003: Moore Lisa J; Pridmore Alison C; Dower Steven K; Read Robert C
Penicillin enhances the toll-like receptor 2-mediated proinflammatory activity of Streptococcus pneumoniae.
The Journal of infectious diseases 2003;188(7):1040-8.
2003: Sabroe Ian; Read Robert C; Whyte Moira K B; Dockrell David H; Vogel Stefanie N; Dower Steven K
Toll-like receptors in health and disease: complex questions remain.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(4):1630-5.
2003: Pridmore Alison C; Jarvis Gary A; John Constance M; Jack Dominic L; Dower Steven K; Read Robert C
Activation of toll-like receptor 2 (TLR2) and TLR4/MD2 by Neisseria is independent of capsule and lipooligosaccharide (LOS) sialylation but varies widely among LOS from different strains.
Infection and immunity 2003;71(7):3901-8.
2003: Sabroe Ian; Prince Lynne R; Jones Elizabeth C; Horsburgh Malcolm J; Foster Simon J; Vogel Stefanie N; Dower Steven K; Whyte Moira K B
Selective roles for Toll-like receptor (TLR)2 and TLR4 in the regulation of neutrophil activation and life span.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(10):5268-75.
2003: Renshaw Stephen A; Parmar Jasvir S; Singleton Vanessa; Rowe Sarah J; Dockrell David H; Dower Steven K; Bingle Colin D; Chilvers Edwin R; Whyte Moira K B
Acceleration of human neutrophil apoptosis by TRAIL.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(2):1027-33.
2003: Schooley Kenneth; Zhu Ping; Dower Steven K; Qwarnström Eva E
Regulation of nuclear translocation of nuclear factor-kappaB relA: evidence for complex dynamics at the single-cell level.
The Biochemical journal 2003;369(Pt 2):331-9.
2002: Ross Kehinde; Yang Lin; Dower Steve; Volpe Filippo; Guesdon Francois
Identification of threonine 66 as a functionally critical residue of the interleukin-1 receptor-associated kinase.
The Journal of biological chemistry 2002;277(40):37414-21.
2002: Sabroe I; Parker L C; Wilson A G; Whyte M K B; Dower S K
Toll-like receptors: their role in allergy and non-allergic inflammatory disease.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2002;32(7):984-9.
2002: Sabroe Ian; Jones Elizabeth C; Usher Lynne R; Whyte Moira K B; Dower Steven K
Toll-like receptor (TLR)2 and TLR4 in human peripheral blood granulocytes: a critical role for monocytes in leukocyte lipopolysaccharide responses.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(9):4701-10.
2001: MacKenzie A; Wilson H L; Kiss-Toth E; Dower S K; North R A; Surprenant A
Rapid secretion of interleukin-1beta by microvesicle shedding.
Immunity 2001;15(5):825-35.
2001: Read R C; Pullin J; Gregory S; Borrow R; Kaczmarski E B; di Giovine F S; Dower S K; Cannings C; Wilson A G
A functional polymorphism of toll-like receptor 4 is not associated with likelihood or severity of meningococcal disease.
The Journal of infectious diseases 2001;184(5):640-2.
2001: Kiss-Toth E; Dower S K; Sayers J R
A method for enhancing the transfection efficiency of minipreps obtained from plasmid cDNA libraries.
Analytical biochemistry 2001;288(2):230-2.
2001: Visintin A; Mazzoni A; Spitzer J H; Wyllie D H; Dower S K; Segal D M
Regulation of Toll-like receptors in human monocytes and dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(1):249-55.
2001: Pridmore A C; Wyllie D H; Abdillahi F; Steeghs L; van der Ley P; Dower S K; Read R C
A lipopolysaccharide-deficient mutant of Neisseria meningitidis elicits attenuated cytokine release by human macrophages and signals via toll-like receptor (TLR) 2 but not via TLR4/MD2.
The Journal of infectious diseases 2001;183(1):89-96.
2000: Wyllie D H; Kiss-Toth E; Visintin A; Smith S C; Boussouf S; Segal D M; Duff G W; Dower S K
Evidence for an accessory protein function for Toll-like receptor 1 in anti-bacterial responses.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):7125-32.
2000: Carlotti F; Dower S K; Qwarnstrom E E
Dynamic shuttling of nuclear factor kappa B between the nucleus and cytoplasm as a consequence of inhibitor dissociation.
The Journal of biological chemistry 2000;275(52):41028-34.
2000: Bowie A; Kiss-Toth E; Symons J A; Smith G L; Dower S K; O'Neill L A
A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(18):10162-7.
2000: Kiss-Toth E; Guesdon F M; Wyllie D H; Qwarnstrom E E; Dower S K
A novel mammalian expression screen exploiting green fluorescent protein-based transcription detection in single cells.
Journal of immunological methods 2000;239(1-2):125-35.
2000: Slack J L; Schooley K; Bonnert T P; Mitcham J L; Qwarnstrom E E; Sims J E; Dower S K
Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to pro-inflammatory signaling pathways.
The Journal of biological chemistry 2000;275(7):4670-8.
1999: Carlotti F; Chapman R; Dower S K; Qwarnstrom E E
Activation of nuclear factor kappaB in single living cells. Dependence of nuclear translocation and anti-apoptotic function on EGFPRELA concentration.
The Journal of biological chemistry 1999;274(53):37941-9.
1999: Vallés S; Tsoi C; Huang W Y; Wyllie D; Carlotti F; Askari J A; Humphries M J; Dower S K; Qwarnström E E
Recruitment of a heparan sulfate subunit to the interleukin-1 receptor complex. Regulation by fibronectin attachment.
The Journal of biological chemistry 1999;274(29):20103-9.
1999: Maamra M; Finidori J; Von Laue S; Simon S; Justice S; Webster J; Dower S; Ross R
Studies with a growth hormone antagonist and dual-fluorescent confocal microscopy demonstrate that the full-length human growth hormone receptor, but not the truncated isoform, is very rapidly internalized independent of Jak2-Stat5 signaling.
The Journal of biological chemistry 1999;274(21):14791-8.
1998: Wojcik J; Berg M A; Esposito N; Geffner M E; Sakati N; Reiter E O; Dower S; Francke U; Postel-Vinay M C; Finidori J
Four contiguous amino acid substitutions, identified in patients with Laron syndrome, differently affect the binding affinity and intracellular trafficking of the growth hormone receptor.
The Journal of clinical endocrinology and metabolism 1998;83(12):4481-9.
1998: Royds J A; Dower S K; Qwarnstrom E E; Lewis C E
Response of tumour cells to hypoxia: role of p53 and NFkB.
Molecular pathology : MP 1998;51(2):55-61.
1997: Bird T A; Schooley K; Dower S K; Hagen H; Virca G D
Activation of nuclear transcription factor NF-kappaB by interleukin-1 is accompanied by casein kinase II-mediated phosphorylation of the p65 subunit.
The Journal of biological chemistry 1997;272(51):32606-12.
1996: Colotta F; Saccani S; Giri J G; Dower S K; Sims J E; Introna M; Mantovani A
Regulated expression and release of the IL-1 decoy receptor in human mononuclear phagocytes.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(7):2534-41.
1996: Re F; Sironi M; Muzio M; Matteucci C; Introna M; Orlando S; Penton-Rol G; Dower S K; Sims J E; Colotta F; Mantovani A
Inhibition of interleukin-1 responsiveness by type II receptor gene transfer: a surface "receptor" with anti-interleukin-1 function.
The Journal of experimental medicine 1996;183(4):1841-50.
1996: Gruss H J; Ulrich D; Dower S K; Herrmann F; Brach M A
Activation of Hodgkin cells via the CD30 receptor induces autocrine secretion of interleukin-6 engaging the NF-kappabeta transcription factor.
Blood 1996;87(6):2443-9.
1996: Gayle M A; Slack J L; Bonnert T P; Renshaw B R; Sonoda G; Taguchi T; Testa J R; Dower S K; Sims J E
Cloning of a putative ligand for the T1/ST2 receptor.
The Journal of biological chemistry 1996;271(10):5784-9.
1996: Mitcham J L; Parnet P; Bonnert T P; Garka K E; Gerhart M J; Slack J L; Gayle M A; Dower S K; Sims J E
T1/ST2 signaling establishes it as a member of an expanding interleukin-1 receptor family.
The Journal of biological chemistry 1996;271(10):5777-83.
1996: Parnet P; Garka K E; Bonnert T P; Dower S K; Sims J E
IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP.
The Journal of biological chemistry 1996;271(8):3967-70.
1995: Slack J L; Armitage R J; Ziegler S F; Dower S K; Gruss H J
Molecular characterization of the pan-B cell antigen CDw78 as a MHC class II molecule by direct expression cloning of the transcription factor CIITA.
International immunology 1995;7(7):1087-92.
1995: Gruss H J; Ulrich D; Braddy S; Armitage R J; Dower S K
Recombinant CD30 ligand and CD40 ligand share common biological activities on Hodgkin and Reed-Sternberg cells.
European journal of immunology 1995;25(7):2083-9.
1995: Gruss H J; Dower S K
Tumor necrosis factor ligand superfamily: involvement in the pathology of malignant lymphomas.
Blood 1995;85(12):3378-404.
1994: Giri J G; Wells J; Dower S K; McCall C E; Guzman R N; Slack J; Bird T A; Shanebeck K; Grabstein K H; Sims J E
Elevated levels of shed type II IL-1 receptor in sepsis. Potential role for type II receptor in regulation of IL-1 responses.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(12):5802-9.
1994: Arend W P; Malyak M; Smith M F; Whisenand T D; Slack J L; Sims J E; Giri J G; Dower S K
Binding of IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist by soluble IL-1 receptors and levels of soluble IL-1 receptors in synovial fluids.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(10):4766-74.
1994: Sims J E; Dower S K
Interleukin-1 receptors.
European cytokine network 1994;5(6):539-46.
1994: Gruss H J; Hirschstein D; Wright B; Ulrich D; Caligiuri M A; Barcos M; Strockbine L; Armitage R J; Dower S K
Expression and function of CD40 on Hodgkin and Reed-Sternberg cells and the possible relevance for Hodgkin's disease.
Blood 1994;84(7):2305-14.
1994: Nagoya S; Greenberg P D; Yee C; Weisser K E; Sugawara H; Widmer M B; Slack J; Dower S K; Lupton S D; Overell R W
Helper T cell-independent proliferation of CD8+ cytotoxic T lymphocytes transduced with an IL-1 receptor retrovirus.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(4):1527-35.
1994: Sims J E; Giri J G; Dower S K
The two interleukin-1 receptors play different roles in IL-1 actions.
Clinical immunology and immunopathology 1994;72(1):9-14.
1994: Dower S K; Fanslow W; Jacobs C; Waugh S; Sims J E; Widmer M B
Interleukin-I antagonists.
Therapeutic immunology 1994;1(2):113-22.
1994: Thoma B; Bird T A; Friend D J; Gearing D P; Dower S K
Oncostatin M and leukemia inhibitory factor trigger overlapping and different signals through partially shared receptor complexes.
The Journal of biological chemistry 1994;269(8):6215-22.
1994: Bird T A; Schule H D; Delaney P; de Roos P; Sleath P; Dower S K; Virca G D
The interleukin-1-stimulated protein kinase that phosphorylates heat shock protein hsp27 is activated by MAP kinase.
FEBS letters 1994;338(1):31-6.
1994: Gayle M A; Sims J E; Dower S K; Slack J L
Monoclonal antibody 1994-01 (also known as ALVA 42) reported to recognize type II IL-1 receptor is specific for HLA-DR alpha and beta chains.
Cytokine 1994;6(1):83-6.
1993: Gayle R B; Poindexter K; Cosman D; Dower S K; Gillis S; Hopp T; Jerzy R; Kronheim S; Lum V; Lewis A
Identification of regions in interleukin-1 alpha important for activity.
The Journal of biological chemistry 1993;268(29):22105-11.
1993: Iwasaki T; Sims J E; Grabstein K; Dower S K; Rachie N; Bomsztyk K
Comparison of IL-1 alpha effectiveness in activating murine pre-B and T cell lines.
Cytokine 1993;5(5):416-26.
1993: Colotta F; Re F; Muzio M; Bertini R; Polentarutti N; Sironi M; Giri J G; Dower S K; Sims J E; Mantovani A
Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4.
Science (New York, N.Y.) 1993;261(5120):472-5.
1993: Slack J; McMahan C J; Waugh S; Schooley K; Spriggs M K; Sims J E; Dower S K
Independent binding of interleukin-1 alpha and interleukin-1 beta to type I and type II interleukin-1 receptors.
The Journal of biological chemistry 1993;268(4):2513-24.
1993: Dower S K
Cytokine receptor families.
Advances in second messenger and phosphoprotein research 1993;28():19-25.
1992: Bird T A; Schule H D; Delaney P B; Sims J E; Thoma B; Dower S K
Evidence that MAP (mitogen-activated protein) kinase activation may be a necessary but not sufficient signal for a restricted subset of responses in IL-1-treated epidermoid cells.
Cytokine 1992;4(6):429-40.
1992: Deyerle K L; Sims J E; Dower S K; Bothwell M A
Pattern of IL-1 receptor gene expression suggests role in noninflammatory processes.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(5):1657-65.
1992: Grabstein K H; Baker P E; Hess B; Clark L; Slack J; Sims J E; Alpert A R; Dower S; Weisser K E; Overell R W
Regulation of murine B-cell growth in vitro by infection with a retroviral vector containing the murine IL-1R.
Annals of the New York Academy of Sciences 1992;651():474-6.
1992: Dower S K; Sims J E; Cerretti D P; Bird T A
The interleukin-1 system: receptors, ligands and signals.
Chemical immunology 1992;51():33-64.
1991: Bird T A; Sleath P R; deRoos P C; Dower S K; Virca G D
Interleukin-1 represents a new modality for the activation of extracellular signal-regulated kinases/microtubule-associated protein-2 kinases.
The Journal of biological chemistry 1991;266(33):22661-70.
1991: Ostrowski J; Sims J E; Sibley C H; Valentine M A; Dower S K; Meier K E; Bomsztyk K
A serine/threonine kinase activity is closely associated with a 65-kDa phosphoprotein specifically recognized by the kappa B enhancer element.
The Journal of biological chemistry 1991;266(19):12722-33.
1991: Bird T A; Woodward A; Jackson J L; Dower S K; Sims J E
Phorbol ester induces phosphorylation of the 80 kilodalton murine interleukin 1 receptor at a single threonine residue.
Biochemical and biophysical research communications 1991;177(1):61-7.
1991: Bomsztyk K; Rooney J W; Iwasaki T; Rachie N A; Dower S K; Sibley C H
Evidence that interleukin-1 and phorbol esters activate NF-kappa B by different pathways: role of protein kinase C.
Cell regulation 1991;2(4):329-35.
1991: Qwarnström E E; MacFarlane S A; Page R C; Dower S K
Interleukin 1 beta induces rapid phosphorylation and redistribution of talin: a possible mechanism for modulation of fibroblast focal adhesion.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(4):1232-6.
1990: Spriggs M K; Lioubin P J; Slack J; Dower S K; Jonas U; Cosman D; Sims J E; Bauer J
Induction of an interleukin-1 receptor (IL-1R) on monocytic cells. Evidence that the receptor is not encoded by a T cell-type IL-1R mRNA.
The Journal of biological chemistry 1990;265(36):22499-505.
1990: Dower S K; Smith C A; Park L S
Human cytokine receptors.
Journal of clinical immunology 1990;10(6):289-99.
1990: Bomsztyk K; Toivola B; Emery D W; Rooney J W; Dower S K; Rachie N A; Sibley C H
Role of cAMP in interleukin-1-induced kappa light chain gene expression in murine B cell line.
The Journal of biological chemistry 1990;265(16):9413-7.
1990: Dower S K; Sims J E
Molecular characterisation of cytokine receptors.
Annals of the rheumatic diseases 1990;49 Suppl 1():452-9.
1990: Dower S K; Qwarnstrom E E; Page R C; Blanton R A; Kupper T S; Raines E; Ross R; Sims J E
Biology of the interleukin-1 receptor.
The Journal of investigative dermatology 1990;94(6 Suppl):68S-73S.
1990: Wilson C A; Jacobs C; Baker P; Baskin D G; Dower S; Lernmark A; Toivola B; Vertrees S; Wilson D
IL-1 beta modulation of spontaneous autoimmune diabetes and thyroiditis in the BB rat.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(10):3784-8.
1990: Smith C A; Davis T; Anderson D; Solam L; Beckmann M P; Jerzy R; Dower S K; Cosman D; Goodwin R G
A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins.
Science (New York, N.Y.) 1990;248(4958):1019-23.
1990: Fanslow W C; Sims J E; Sassenfeld H; Morrissey P J; Gillis S; Dower S K; Widmer M B
Regulation of alloreactivity in vivo by a soluble form of the interleukin-1 receptor.
Science (New York, N.Y.) 1990;248(4956):739-42.
1990: Park L S; Friend D J; Schmierer A E; Dower S K; Namen A E
Murine interleukin 7 (IL-7) receptor. Characterization on an IL-7-dependent cell line.
The Journal of experimental medicine 1990;171(4):1073-89.
1990: Maliszewski C R; Sato T A; Vanden Bos T; Waugh S; Dower S K; Slack J; Beckmann M P; Grabstein K H
Cytokine receptors and B cell functions. I. Recombinant soluble receptors specifically inhibit IL-1- and IL-4-induced B cell activities in vitro.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(8):3028-33.
1990: Goodwin R G; Friend D; Ziegler S F; Jerzy R; Falk B A; Gimpel S; Cosman D; Dower S K; March C J; Namen A E
Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily.
Cell 1990;60(6):941-51.
1990: Dower S K; Bomzstyk K; Sims J E
Structure of IL-1 receptors.
Progress in clinical and biological research 1990;349():241-9.
1990: Dower S K; Sims J E; Stanton T H; Slack J; McMahan C J; Valentine M A; Bomsztyk K
Molecular heterogeneity of interleukin-1 receptors.
Annals of the New York Academy of Sciences 1990;594():231-9.
1989: Sims J E; Acres R B; Grubin C E; McMahan C J; Wignall J M; March C J; Dower S K
Cloning the interleukin 1 receptor from human T cells.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(22):8946-50.
1989: Gallis B; Prickett K S; Jackson J; Slack J; Schooley K; Sims J E; Dower S K
IL-1 induces rapid phosphorylation of the IL-1 receptor.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(10):3235-40.
1989: Bomsztyk K; Sims J E; Stanton T H; Slack J; McMahan C J; Valentine M A; Dower S K
Evidence for different interleukin 1 receptors in murine B- and T-cell lines.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(20):8034-8.
1989: Dower S K; Wignall J M; Schooley K; McMahan C J; Jackson J L; Prickett K S; Lupton S; Cosman D; Sims J E
Retention of ligand binding activity by the extracellular domain of the IL-1 receptor.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(12):4314-20.
1989: Curtis B M; Gallis B; Overell R W; McMahan C J; DeRoos P; Ireland R; Eisenman J; Dower S K; Sims J E
T-cell interleukin 1 receptor cDNA expressed in Chinese hamster ovary cells regulates functional responses to interleukin 1.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(9):3045-9.
1989: Bomsztyk K; Stanton T H; Smith L L; Rachie N A; Dower S K
Properties of interleukin-1 and interferon-gamma receptors in B lymphoid cell line.
The Journal of biological chemistry 1989;264(11):6052-7.
1989: Klarnet J P; Kern D E; Dower S K; Matis L A; Cheever M A; Greenberg P D
Helper-independent CD8+ cytotoxic T lymphocytes express IL-1 receptors and require IL-1 for secretion of IL-2.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(7):2187-91.
1989: Raines E W; Dower S K; Ross R
Interleukin-1 mitogenic activity for fibroblasts and smooth muscle cells is due to PDGF-AA.
Science (New York, N.Y.) 1989;243(4889):393-6.
1988: Qwarnstrom E E; Page R C; Gillis S; Dower S K
Binding, internalization, and intracellular localization of interleukin-1 beta in human diploid fibroblasts.
The Journal of biological chemistry 1988;263(17):8261-9.
1988: Urdal D L; Call S M; Jackson J L; Dower S K
Affinity purification and chemical analysis of the interleukin-1 receptor.
The Journal of biological chemistry 1988;263(6):2870-7.
1987: Mosley B; Urdal D L; Prickett K S; Larsen A; Cosman D; Conlon P J; Gillis S; Dower S K
The interleukin-1 receptor binds the human interleukin-1 alpha precursor but not the interleukin-1 beta precursor.
The Journal of biological chemistry 1987;262(7):2941-4.
1987: Dower S K; Mosley B; Conlon P J; Benson P; Grubin C; Larsen A; Gillis S; Cosman D
Molecular modification of lymphokines by in vitro mutagenesis.
Annals of the New York Academy of Sciences 1987;507():22-31.
1986: Dower S K; Kronheim S R; Hopp T P; Cantrell M; Deeley M; Gillis S; Henney C S; Urdal D L
The cell surface receptors for interleukin-1 alpha and interleukin-1 beta are identical.
Nature 1986;324(6094):266-8.
1986: Gillis S; Conlon P J; Cosman D; Hopp T P; Dower S K; Price V; Mochizuki D Y; Urdal D L
Lymphokines: from conjecture to the clinic.
Seminars in oncology 1986;13(2):218-27.
1986: Dower S K; Call S M; Gillis S; Urdal D L
Similarity between the interleukin 1 receptors on a murine T-lymphoma cell line and on a murine fibroblast cell line.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(4):1060-4.
1985: Dower S K; Kronheim S R; March C J; Conlon P J; Hopp T P; Gillis S; Urdal D L
Detection and characterization of high affinity plasma membrane receptors for human interleukin 1.
The Journal of experimental medicine 1985;162(2):501-15.

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