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Steven Dower

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Jon R Ward; Sheila E Francis; Luke Marsden; Tesha Suddason; Graham M Lord; Steven K Dower; David C Crossman; Ian Sabroe
A central role for monocytes in Toll-like receptor-mediated activation of the vasculature.
Katalin Eder; Hongtao Guan; Hye Y Sung; Jon Ward; Adrienn Angyal; Michelle Janas; Gabriella Sarmay; Erno Duda; Martin Turner; Steven K Dower; Sheila E Francis; David C Crossman; Endre Kiss-Toth
Tribbles-2 is a novel regulator of inflammatory activation of monocytes.
I Sabroe; Lisa C Parker; P M A Calverley; Steven K Dower; M K B Whyte
Pathological networking: a new approach to understanding COPD.

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All Publications

2009: Jon R Ward; Sheila E Francis; Luke Marsden; Tesha Suddason; Graham M Lord; Steven K Dower; David C Crossman; Ian Sabroe
A central role for monocytes in Toll-like receptor-mediated activation of the vasculature.
Immunology 2009;128(1):58-68.
2008: Katalin Eder; Hongtao Guan; Hye Y Sung; Jon Ward; Adrienn Angyal; Michelle Janas; Gabriella Sarmay; Erno Duda; Martin Turner; Steven K Dower; Sheila E Francis; David C Crossman; Endre Kiss-Toth
Tribbles-2 is a novel regulator of inflammatory activation of monocytes.
International immunology 2008;20(12):1543-50.
2008: I Sabroe; Lisa C Parker; P M A Calverley; Steven K Dower; M K B Whyte
Pathological networking: a new approach to understanding COPD.
Postgraduate medical journal 2008;84(991):259-64.
2008: Hongtao Guan; Endre Kiss-Toth; Steven K Dower
Analysis of innate immune signal transduction with autocatalytic expression vectors.
Journal of immunological methods 2008;330(1-2):96-108.
2007: Ian Sabroe; Lisa C Parker; Steven K Dower; Moira K B Whyte
Practical and conceptual models of chronic obstructive pulmonary disease.
Proceedings of the American Thoracic Society 2007;4(8):606-10.
2007: Ian Sabroe; Lisa C Parker; P M A Calverley; Steven K Dower; Moira K B Whyte
Pathological networking: a new approach to understanding COPD.
Thorax 2007;62(8):733-8.
2007: Hye-Youn Sung; Hongtao Guan; Agnes Czibula; Andrea R King; Katalin Eder; Emily Heath; S Kim Suvarna; Steven K Dower; Anthony G Wilson; Sheila E Francis; David C Crossman; Endre Kiss-Toth
Human tribbles-1 controls proliferation and chemotaxis of smooth muscle cells via MAPK signaling pathways.
The Journal of biological chemistry 2007;282(25):18379-87.
2007: Heather Wilson; R W Varcoe; Leanne Stokes; K L Holland; Sheila E Francis; Steven K Dower; Annmarie Surprenant; David C Crossman
P2X receptor characterization and IL-1/IL-1Ra release from human endothelial cells.
British journal of pharmacology 2007;151(1):115-27.
2007: Ian Sabroe; Lisa C Parker; David H Dockrell; Donna E Davies; Steven K Dower; Moira K B Whyte
Targeting the networks that underpin contiguous immunity in asthma and chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 2007;175(4):306-11.
2007: Steven K Dower; Eva E Qwarnstrom; Endre Kiss-Toth
Fluorescent protein reporter systems for single-cell measurements.
Methods in molecular biology (Clifton, N.J.) 2007;411():111-9.
2007: Ian Sabroe; David H Dockrell; Stefanie N Vogel; Stephen A Renshaw; Moira K B Whyte; Steven K Dower
Identifying and hurdling obstacles to translational research.
Nature reviews. Immunology 2007;7(1):77-82.
2007: Lisa J Moore; Andrea M Gilbey; Christopher G Dowson; Alison C Pridmore; Steven K Dower; Robert C Read
Proinflammatory activation of Toll-like receptor-2 during exposure of penicillin-resistant Streptococcus pneumoniae to beta-lactam antibiotics.
The Journal of antimicrobial chemotherapy 2007;59(1):35-42.
2006: Hongtao Guan; Karen Holland; Eva E Qwarnstrom; Steven K Dower; Endre Kiss-Toth
Feedback loops in intracellular signal processing and their potential for identifying novel signalling proteins.
Cellular immunology 2006;244(2):158-61.
2006: Gavin E Morris; Lisa C Parker; Jon R Ward; Elizabeth C Jones; Moira K B Whyte; Christopher E Brightling; Peter Bradding; Steven K Dower; Ian Sabroe
Cooperative molecular and cellular networks regulate Toll-like receptor-dependent inflammatory responses.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(12):2153-5.
2006: Janet Chamberlain; David Evans; Andrea King; Rachael Dewberry; Steven K Dower; David C Crossman; Sheila Francis
Interleukin-1beta and signaling of interleukin-1 in vascular wall and circulating cells modulates the extent of neointima formation in mice.
The American journal of pathology 2006;168(4):1396-403.
2006: Jon R Ward; Steven K Dower; Moira K B Whyte; David J Buttle; Ian Sabroe
Potentiation of TLR4 signalling by plasmin activity.
Biochemical and biophysical research communications 2006;341(2):299-303.
2006: Iona Evans; Steven K Dower; Sheila E Francis; David C Crossman; Heather Wilson
Action of intracellular IL-1Ra (Type 1) is independent of the IL-1 intracellular signalling pathway.
Cytokine 2006;33(5):274-80.
2006: Endre Kiss-Toth; David H Wyllie; Karen Holland; Luke Marsden; Veronika Jozsa; Kevin M Oxley; Timea Polgar; Eva E Qwarnstrom; Steven K Dower
Functional mapping and identification of novel regulators for the Toll/Interleukin-1 signalling network by transcription expression cloning.
Cellular signalling 2006;18(2):202-14.
2005: Endre Kiss-Toth; David H Wyllie; Karen Holland; Luke Marsden; Veronika Jozsa; Kevin M Oxley; Timea Polgar; Eva E Qwarnstrom; Steven K Dower
Functional mapping of Toll/interleukin-1 signalling networks by expression cloning.
Biochemical Society transactions 2005;33(Pt 6):1405-6.
2005: Lisa C Parker; Elizabeth C Jones; Lynne R Prince; Steven K Dower; Moira K B Whyte; Ian Sabroe
Endotoxin tolerance induces selective alterations in neutrophil function.
Journal of leukocyte biology 2005;78(6):1301-5.
2005: Allison C Morton; Nadine D Arnold; Julian Gunn; Richard Varcoe; Sheila E Francis; Steven K Dower; David C Crossman
Interleukin-1 receptor antagonist alters the response to vessel wall injury in a porcine coronary artery model.
Cardiovascular research 2005;68(3):493-501.
2005: Ian Sabroe; Steven K Dower; Moira K B Whyte
The role of Toll-like receptors in the regulation of neutrophil migration, activation, and apoptosis.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2005;41 Suppl 7():S421-6.
2005: Jon R Ward; Lynne Bingle; Heather M Judge; Simon B Brown; Robert F Storey; Moira K B Whyte; Steven K Dower; David J Buttle; Ian Sabroe
Agonists of toll-like receptor (TLR)2 and TLR4 are unable to modulate platelet activation by adenosine diphosphate and platelet activating factor.
Thrombosis and haemostasis 2005;94(4):831-8.
2005: Nazia Chaudhuri; Steven K Dower; Moira K B Whyte; Ian Sabroe
Toll-like receptors and chronic lung disease.
Clinical science (London, England : 1979) 2005;109(2):125-33.
2005: András Telekes; Endre Kiss-Tóth; Tünde Nagy; Eva E Qwarnstrom; Erzsébet Kúsz; Timea Polgár; Akos Resetár; Steven K Dower; Erno Duda
Synergistic effect of Avemar on proinflammatory cytokine production and Ras-mediated cell activation.
Annals of the New York Academy of Sciences 2005;1051():515-28.
2005: Lisa C Parker; Moira K B Whyte; Steven K Dower; Ian Sabroe
The expression and roles of Toll-like receptors in the biology of the human neutrophil.
Journal of leukocyte biology 2005;77(6):886-92.
2005: Ian Sabroe; Elizabeth C Jones; Moira K B Whyte; Steven K Dower
Regulation of human neutrophil chemokine receptor expression and function by activation of Toll-like receptors 2 and 4.
Immunology 2005;115(1):90-8.
2005: Gavin E Morris; Moira K B Whyte; Gillian F Martin; Peter J Jose; Steven K Dower; Ian Sabroe
Agonists of toll-like receptors 2 and 4 activate airway smooth muscle via mononuclear leukocytes.
American journal of respiratory and critical care medicine 2005;171(8):814-22.
2004: Lynne R Prince; Lucy Allen; Elizabeth C Jones; Paul G Hellewell; Steven K Dower; Moira K B Whyte; Ian Sabroe
The role of interleukin-1beta in direct and toll-like receptor 4-mediated neutrophil activation and survival.
The American journal of pathology 2004;165(5):1819-26.
2004: Endre Kiss-Toth; Stephanie M Bagstaff; Hye-Youn Sung; Veronika Jozsa; Clare E Dempsey; Jim C Caunt; Kevin M Oxley; David H Wyllie; Timea Polgar; Mary Harte; Luke A J O'Neill; Eva E Qwarnstrom; Steven K Dower
Human tribbles, a protein family controlling mitogen-activated protein kinase cascades.
The Journal of biological chemistry 2004;279(41):42703-8.
2004: Heather Wilson; Sheila E Francis; Steven K Dower; David C Crossman
Secretion of intracellular IL-1 receptor antagonist (type 1) is dependent on P2X7 receptor activation.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(2):1202-8.
2004: Lisa J Moore; Alison C Pridmore; Steven K Dower; Robert C Read
The glycopeptide vancomycin does not enhance toll-like receptor 2 (TLR2) activation by Streptococcus pneumoniae.
The Journal of antimicrobial chemotherapy 2004;54(1):76-8.
2004: Ian Sabroe; Lynne R Prince; Steven K Dower; Sarah R Walmsley; Edwin R Chilvers; Moira K B Whyte
What can we learn from highly purified neutrophils?
Biochemical Society transactions 2004;32(Pt3):468-9.
2004: Lisa C Parker; Moira K B Whyte; Stefanie N Vogel; Steven K Dower; Ian Sabroe
Toll-like receptor (TLR)2 and TLR4 agonists regulate CCR expression in human monocytic cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(8):4977-86.
2004: Endre Kiss-Toth; Eva E Qwarnstrom; Steven K Dower
Hunting for genes by functional screens.
Cytokine & growth factor reviews 2004;15(2-3):97-102.
2004: Stephen A Renshaw; Clare E Dempsey; Frances A Barnes; Stephanie M Bagstaff; Steven K Dower; Colin D Bingle; Moira K B Whyte
Three novel Bid proteins generated by alternative splicing of the human Bid gene.
The Journal of biological chemistry 2004;279(4):2846-55.
2003: Steven K Dower; Eva E Qwarnstrom
Signalling networks, inflammation and innate immunity.
Biochemical Society transactions 2003;31(Pt 6):1462-71.
2003: Allan Lawrie; Axel F Brisken; Sheila E Francis; David H Wyllie; Endre Kiss-Toth; Eva E Qwarnstrom; Steven K Dower; David C Crossman; Christopher M Newman
Ultrasound-enhanced transgene expression in vascular cells is not dependent upon cavitation-induced free radicals.
Ultrasound in medicine & biology 2003;29(10):1453-61.
2003: Lisa J Moore; Alison C Pridmore; Steven K Dower; Robert C Read
Penicillin enhances the toll-like receptor 2-mediated proinflammatory activity of Streptococcus pneumoniae.
The Journal of infectious diseases 2003;188(7):1040-8.
2003: Ian Sabroe; Robert C Read; Moira K B Whyte; David H Dockrell; Stefanie N Vogel; Steven K Dower
Toll-like receptors in health and disease: complex questions remain.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(4):1630-5.
2003: Alison C Pridmore; Gary Jarvis; Constance M John; Dominic L Jack; Steven K Dower; Robert C Read
Activation of toll-like receptor 2 (TLR2) and TLR4/MD2 by Neisseria is independent of capsule and lipooligosaccharide (LOS) sialylation but varies widely among LOS from different strains.
Infection and immunity 2003;71(7):3901-8.
2003: Ian Sabroe; Lynne R Prince; Elizabeth C Jones; Malcolm J Horsburgh; Simon J Foster; Stefanie N Vogel; Steven K Dower; Moira K B Whyte
Selective roles for Toll-like receptor (TLR)2 and TLR4 in the regulation of neutrophil activation and life span.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(10):5268-75.
2003: Stephen A Renshaw; Jasvir S Parmar; Vanessa Singleton; Sarah J Rowe; David H Dockrell; Steven K Dower; Colin D Bingle; Edwin R Chilvers; Moira K B Whyte
Acceleration of human neutrophil apoptosis by TRAIL.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(2):1027-33.
2003: Kenneth Schooley; Ping Zhu; Steven K Dower; Eva E Qwarnström
Regulation of nuclear translocation of nuclear factor-kappaB relA: evidence for complex dynamics at the single-cell level.
The Biochemical journal 2003;369(Pt 2):331-9.
2002: Kehinde Ross; Lin Yang; Steven K Dower; Filippo Volpe; François Guesdon
Identification of threonine 66 as a functionally critical residue of the interleukin-1 receptor-associated kinase.
The Journal of biological chemistry 2002;277(40):37414-21.
2002: Ian Sabroe; Lisa C Parker; Anthony G Wilson; Moira K B Whyte; Steven K Dower
Toll-like receptors: their role in allergy and non-allergic inflammatory disease.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2002;32(7):984-9.
2002: Ian Sabroe; Elizabeth C Jones; Lynne R Usher; Moira K B Whyte; Steven K Dower
Toll-like receptor (TLR)2 and TLR4 in human peripheral blood granulocytes: a critical role for monocytes in leukocyte lipopolysaccharide responses.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(9):4701-10.
2001: A MacKenzie; Heather Wilson; Endre Kiss-Toth; Steven K Dower; R Alan North; Annmarie Surprenant
Rapid secretion of interleukin-1beta by microvesicle shedding.
Immunity 2001;15(5):825-35.
2001: Robert C Read; J Pullin; S Gregory; Raymond Borrow; Edward B Kaczmarski; Francesco S Di Giovine; Steven K Dower; Chris Cannings; Anthony G Wilson
A functional polymorphism of toll-like receptor 4 is not associated with likelihood or severity of meningococcal disease.
The Journal of infectious diseases 2001;184(5):640-2.
2001: Endre Kiss-Toth; Steven K Dower; Jon Sayers
A method for enhancing the transfection efficiency of minipreps obtained from plasmid cDNA libraries.
Analytical biochemistry 2001;288(2):230-2.
2001: Alberto Visintin; Alessandra Mazzoni; Jessica H Spitzer; David H Wyllie; Steven K Dower; David M Segal
Regulation of Toll-like receptors in human monocytes and dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(1):249-55.
2001: Alison C Pridmore; David H Wyllie; F Abdillahi; Liana Steeghs; Peter van der Ley; Steven K Dower; Robert C Read
A lipopolysaccharide-deficient mutant of Neisseria meningitidis elicits attenuated cytokine release by human macrophages and signals via toll-like receptor (TLR) 2 but not via TLR4/MD2.
The Journal of infectious diseases 2001;183(1):89-96.
2000: F Carlotti; Steven K Dower; Eva E Qwarnstrom
Dynamic shuttling of nuclear factor kappa B between the nucleus and cytoplasm as a consequence of inhibitor dissociation.
The Journal of biological chemistry 2000;275(52):41028-34.
2000: David H Wyllie; Endre Kiss-Toth; Alberto Visintin; S C Smith; S Boussouf; David M Segal; Gordon W Duff; Steven K Dower
Evidence for an accessory protein function for Toll-like receptor 1 in anti-bacterial responses.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):7125-32.
2000: A Bowie; Endre Kiss-Toth; J A Symons; G L Smith; Steven K Dower; Luke A J O'Neill
A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(18):10162-7.
2000: Endre Kiss-Toth; F M Guesdon; David H Wyllie; Eva E Qwarnstrom; Steven K Dower
A novel mammalian expression screen exploiting green fluorescent protein-based transcription detection in single cells.
Journal of immunological methods 2000;239(1-2):125-35.
2000: J L Slack; Kenneth Schooley; T P Bonnert; J L Mitcham; Eva E Qwarnstrom; John E Sims; Steven K Dower
Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to pro-inflammatory signaling pathways.
The Journal of biological chemistry 2000;275(7):4670-8.
1999: F Carlotti; R Chapman; Steven K Dower; Eva E Qwarnstrom
Activation of nuclear factor kappaB in single living cells. Dependence of nuclear translocation and anti-apoptotic function on EGFPRELA concentration.
The Journal of biological chemistry 1999;274(53):37941-9.
1999: Soraya L. Valles; C Tsoi; W Y Huang; David H Wyllie; F Carlotti; Janet Askari; M J Humphries; Steven K Dower; E E Qwarnström
Recruitment of a heparan sulfate subunit to the interleukin-1 receptor complex. Regulation by fibronectin attachment.
The Journal of biological chemistry 1999;274(29):20103-9.
1999: Mabrouka Maamra; J Finidori; Sigward von Laue; S Simon; Sue Justice; J Webster; Steven K Dower; R Ross
Studies with a growth hormone antagonist and dual-fluorescent confocal microscopy demonstrate that the full-length human growth hormone receptor, but not the truncated isoform, is very rapidly internalized independent of Jak2-Stat5 signaling.
The Journal of biological chemistry 1999;274(21):14791-8.
1998: J Wojcik; MA Berg; N Esposito; M E Geffner; N Sakati; E O Reiter; Steven K Dower; Uta Francke; Marie Catherine Postel-Vinay; J Finidori
Four contiguous amino acid substitutions, identified in patients with Laron syndrome, differently affect the binding affinity and intracellular trafficking of the growth hormone receptor.
The Journal of clinical endocrinology and metabolism 1998;83(12):4481-9.
1998: Janice A Royds; Steven K Dower; Eva E Qwarnstrom; C E Lewis
Response of tumour cells to hypoxia: role of p53 and NFkB.
Molecular pathology : MP 1998;51(2):55-61.
1997: Timothy A Bird; Kenneth Schooley; Steven K Dower; H Hagen; G Duke Virca
Activation of nuclear transcription factor NF-kappaB by interleukin-1 is accompanied by casein kinase II-mediated phosphorylation of the p65 subunit.
The Journal of biological chemistry 1997;272(51):32606-12.
1996: F Colotta; S Saccani; Judith Goldstein Giri; Steven K Dower; John E Sims; Martino Introna; A Mantovani
Regulated expression and release of the IL-1 decoy receptor in human mononuclear phagocytes.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(7):2534-41.
1996: F Re; Marina Sironi; Marta Muzio; C Matteucci; Martino Introna; S Orlando; G Penton Rol; Steven K Dower; John E Sims; F Colotta; A Mantovani
Inhibition of interleukin-1 responsiveness by type II receptor gene transfer: a surface "receptor" with anti-interleukin-1 function.
The Journal of experimental medicine 1996;183(4):1841-50.
1996: HJ Gruss; D Ulrich; Steven K Dower; F Herrmann; M A Brach
Activation of Hodgkin cells via the CD30 receptor induces autocrine secretion of interleukin-6 engaging the NF-kappabeta transcription factor.
Blood 1996;87(6):2443-9.
1996: M A Gayle; JL Slack; T P Bonnert; Blair R Renshaw; G Sonoda; T Taguchi; J R Testa; Steven K Dower; John E Sims
Cloning of a putative ligand for the T1/ST2 receptor.
The Journal of biological chemistry 1996;271(10):5784-9.
1996: J L Mitcham; patricia parnet; T P Bonnert; K E Garka; Mary J Gerhart; JL Slack; M A Gayle; Steven K Dower; John E Sims
T1/ST2 signaling establishes it as a member of an expanding interleukin-1 receptor family.
The Journal of biological chemistry 1996;271(10):5777-83.
1996: patricia parnet; K E Garka; T P Bonnert; Steven K Dower; John E Sims
IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP.
The Journal of biological chemistry 1996;271(8):3967-70.
1995: J L Slack; Richard J Armitage; S F Ziegler; Steven K Dower; HJ Gruss
Molecular characterization of the pan-B cell antigen CDw78 as a MHC class II molecule by direct expression cloning of the transcription factor CIITA.
International immunology 1995;7(7):1087-92.
1995: HJ Gruss; D Ulrich; S Braddy; Richard J Armitage; Steven K Dower
Recombinant CD30 ligand and CD40 ligand share common biological activities on Hodgkin and Reed-Sternberg cells.
European journal of immunology 1995;25(7):2083-9.
1995: HJ Gruss; Steven K Dower
Tumor necrosis factor ligand superfamily: involvement in the pathology of malignant lymphomas.
Blood 1995;85(12):3378-404.
1994: Judith Goldstein Giri; J Wells; Steven K Dower; Charles E McCall; R N Guzman; J Slack; Timothy A Bird; K Shanebeck; Kenneth H Grabstein; John E Sims
Elevated levels of shed type II IL-1 receptor in sepsis. Potential role for type II receptor in regulation of IL-1 responses.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(12):5802-9.
1994: William P Arend; M Malyak; Michael Smith, Jr.; T D Whisenand; JL Slack; John E Sims; Judith Goldstein Giri; Steven K Dower
Binding of IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist by soluble IL-1 receptors and levels of soluble IL-1 receptors in synovial fluids.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(10):4766-74.
1994: John E Sims; Steven K Dower
Interleukin-1 receptors.
European cytokine network 1994;5(6):539-46.
1994: HJ Gruss; D Hirschstein; B Wright; D Ulrich; M A Caligiuri; M Barcos; L Strockbine; Richard J Armitage; Steven K Dower
Expression and function of CD40 on Hodgkin and Reed-Sternberg cells and the possible relevance for Hodgkin's disease.
Blood 1994;84(7):2305-14.
1994: S Nagoya; Philip D Greenberg; Cassian Yee; K E Weisser; H Sugawara; M B Widmer; J Slack; Steven K Dower; S D Lupton; R W Overell
Helper T cell-independent proliferation of CD8+ cytotoxic T lymphocytes transduced with an IL-1 receptor retrovirus.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(4):1527-35.
1994: John E Sims; Judith Goldstein Giri; Steven K Dower
The two interleukin-1 receptors play different roles in IL-1 actions.
Clinical immunology and immunopathology 1994;72(1):9-14.
1994: Steven K Dower; W Fanslow; C Jacobs; S Waugh; John E Sims; M B Widmer
Interleukin-I antagonists.
Therapeutic immunology 1994;1(2):113-22.
1994: B Thoma; Timothy A Bird; D J Friend; D P Gearing; Steven K Dower
Oncostatin M and leukemia inhibitory factor trigger overlapping and different signals through partially shared receptor complexes.
The Journal of biological chemistry 1994;269(8):6215-22.
1994: Timothy A Bird; H D Schule; P Delaney; P de Roos; P Sleath; Steven K Dower; G D Virca
The interleukin-1-stimulated protein kinase that phosphorylates heat shock protein hsp27 is activated by MAP kinase.
FEBS letters 1994;338(1):31-6.
1994: M A Gayle; John E Sims; Steven K Dower; JL Slack
Monoclonal antibody 1994-01 (also known as ALVA 42) reported to recognize type II IL-1 receptor is specific for HLA-DR alpha and beta chains.
Cytokine 1994;6(1):83-6.
1993: R B Gayle; K Poindexter; David Cosman; Steven K Dower; S Gillis; T Hopp; R Jerzy; S Kronheim; V Lum; A Lewis
Identification of regions in interleukin-1 alpha important for activity.
The Journal of biological chemistry 1993;268(29):22105-11.
1993: T Iwasaki; John E Sims; Kenneth H Grabstein; Steven K Dower; N Rachie; Karol Bomsztyk
Comparison of IL-1 alpha effectiveness in activating murine pre-B and T cell lines.
Cytokine 1993;5(5):416-26.
1993: F Colotta; F Re; Marta Muzio; R Bertini; Nadia Polentarutti; Marina Sironi; Judith Goldstein Giri; Steven K Dower; John E Sims; A Mantovani
Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4.
Science (New York, N.Y.) 1993;261(5120):472-5.
1993: J Slack; C J McMahan; S Waugh; Kenneth Schooley; Melanie Spriggs; John E Sims; Steven K Dower
Independent binding of interleukin-1 alpha and interleukin-1 beta to type I and type II interleukin-1 receptors.
The Journal of biological chemistry 1993;268(4):2513-24.
1993: Steven K Dower
Cytokine receptor families.
Advances in second messenger and phosphoprotein research 1993;28():19-25.
1992: Timothy A Bird; H D Schule; P B Delaney; John E Sims; B Thoma; Steven K Dower
Evidence that MAP (mitogen-activated protein) kinase activation may be a necessary but not sufficient signal for a restricted subset of responses in IL-1-treated epidermoid cells.
Cytokine 1992;4(6):429-40.
1992: K L Deyerle; John E Sims; Steven K Dower; Mark Bothwell
Pattern of IL-1 receptor gene expression suggests role in noninflammatory processes.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(5):1657-65.
1992: Kenneth H Grabstein; P E Baker; B Hess; L Clark; J Slack; John E Sims; A R Alpert; Steven K Dower; K E Weisser; R W Overell
Regulation of murine B-cell growth in vitro by infection with a retroviral vector containing the murine IL-1R.
Annals of the New York Academy of Sciences 1992;651():474-6.
1992: Steven K Dower; John E Sims; D P Cerretti; Timothy A Bird
The interleukin-1 system: receptors, ligands and signals.
Chemical immunology 1992;51():33-64.
1991: Timothy A Bird; P R Sleath; P C deRoos; Steven K Dower; G D Virca
Interleukin-1 represents a new modality for the activation of extracellular signal-regulated kinases/microtubule-associated protein-2 kinases.
The Journal of biological chemistry 1991;266(33):22661-70.
1991: Jerzy Ostrowski; John E Sims; Carol Hopkins Sibley; M A Valentine; Steven K Dower; Kathryn E Meier; Karol Bomsztyk
A serine/threonine kinase activity is closely associated with a 65-kDa phosphoprotein specifically recognized by the kappa B enhancer element.
The Journal of biological chemistry 1991;266(19):12722-33.
1991: Timothy A Bird; A Woodward; J L Jackson; Steven K Dower; John E Sims
Phorbol ester induces phosphorylation of the 80 kilodalton murine interleukin 1 receptor at a single threonine residue.
Biochemical and biophysical research communications 1991;177(1):61-7.
1991: Karol Bomsztyk; J W Rooney; T Iwasaki; N A Rachie; Steven K Dower; Carol Hopkins Sibley
Evidence that interleukin-1 and phorbol esters activate NF-kappa B by different pathways: role of protein kinase C.
Cell regulation 1991;2(4):329-35.
1991: E E Qwarnström; S A MacFarlane; Roy C Page; Steven K Dower
Interleukin 1 beta induces rapid phosphorylation and redistribution of talin: a possible mechanism for modulation of fibroblast focal adhesion.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(4):1232-6.
1990: Melanie Spriggs; P J Lioubin; J Slack; Steven K Dower; U Jonas; David Cosman; John E Sims; J Bauer
Induction of an interleukin-1 receptor (IL-1R) on monocytic cells. Evidence that the receptor is not encoded by a T cell-type IL-1R mRNA.
The Journal of biological chemistry 1990;265(36):22499-505.
1990: Steven K Dower; C A Smith; L S Park
Human cytokine receptors.
Journal of clinical immunology 1990;10(6):289-99.
1990: Karol Bomsztyk; Bert Toivola; David W Emery; J W Rooney; Steven K Dower; N A Rachie; Carol Hopkins Sibley
Role of cAMP in interleukin-1-induced kappa light chain gene expression in murine B cell line.
The Journal of biological chemistry 1990;265(16):9413-7.
1990: Steven K Dower; John E Sims
Molecular characterisation of cytokine receptors.
Annals of the rheumatic diseases 1990;49 Suppl 1():452-9.
1990: Steven K Dower; Eva E Qwarnstrom; R C Page; R A Blanton; T S Kupper; E Raines; R Ross; J E Sims
Biology of the interleukin-1 receptor.
The Journal of investigative dermatology 1990;94(6 Suppl):68S-73S.
1990: CA Smith; T Davis; D Anderson; L Solam; M P Beckmann; R Jerzy; Steven K Dower; David Cosman; RG Goodwin
A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins.
Science (New York, N.Y.) 1990;248(4958):1019-23.
1990: C A Wilson; C Jacobs; P Baker; Denis Baskin; Steven K Dower; Ake Lernmark; Bert Toivola; S Vertrees; D Wilson
IL-1 beta modulation of spontaneous autoimmune diabetes and thyroiditis in the BB rat.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(10):3784-8.
1990: W C Fanslow; John E Sims; H Sassenfeld; PJ Morrissey; S Gillis; Steven K Dower; M B Widmer
Regulation of alloreactivity in vivo by a soluble form of the interleukin-1 receptor.
Science (New York, N.Y.) 1990;248(4956):739-42.
1990: Charles R Maliszewski; T A Sato; T Vanden Bos; S Waugh; Steven K Dower; J Slack; M P Beckmann; Kenneth H Grabstein
Cytokine receptors and B cell functions. I. Recombinant soluble receptors specifically inhibit IL-1- and IL-4-induced B cell activities in vitro.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(8):3028-33.
1990: L S Park; D J Friend; A E Schmierer; Steven K Dower; A E Namen
Murine interleukin 7 (IL-7) receptor. Characterization on an IL-7-dependent cell line.
The Journal of experimental medicine 1990;171(4):1073-89.
1990: RG Goodwin; D Friend; Steven F Ziegler; R Jerzy; B A Falk; S Gimpel; David Cosman; Steven K Dower; CJ March; A E Namen
Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily.
Cell 1990;60(6):941-51.
1990: Steven K Dower; K Bomzstyk; John E Sims
Structure of IL-1 receptors.
Progress in clinical and biological research 1990;349():241-9.
1990: Steven K Dower; John E Sims; T H Stanton; J Slack; C J McMahan; M A Valentine; Karol Bomsztyk
Molecular heterogeneity of interleukin-1 receptors.
Annals of the New York Academy of Sciences 1990;594():231-9.
1989: Byron Gallis; K S Prickett; J Jackson; J Slack; Kenneth Schooley; John E Sims; Steven K Dower
IL-1 induces rapid phosphorylation of the IL-1 receptor.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(10):3235-40.
1989: John E Sims; R B Acres; C E Grubin; C J McMahan; J M Wignall; CJ March; Steven K Dower
Cloning the interleukin 1 receptor from human T cells.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(22):8946-50.
1989: Karol Bomsztyk; John E Sims; T H Stanton; J Slack; C J McMahan; M A Valentine; Steven K Dower
Evidence for different interleukin 1 receptors in murine B- and T-cell lines.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(20):8034-8.
1989: Steven K Dower; J M Wignall; Kenneth Schooley; C J McMahan; J L Jackson; K S Prickett; S Lupton; David Cosman; John E Sims
Retention of ligand binding activity by the extracellular domain of the IL-1 receptor.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(12):4314-20.
1989: B M Curtis; Byron Gallis; R W Overell; C J McMahan; P DeRoos; R Ireland; J Eisenman; Steven K Dower; John E Sims
T-cell interleukin 1 receptor cDNA expressed in Chinese hamster ovary cells regulates functional responses to interleukin 1.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(9):3045-9.
1989: Karol Bomsztyk; T H Stanton; L L Smith; N A Rachie; Steven K Dower
Properties of interleukin-1 and interferon-gamma receptors in B lymphoid cell line.
The Journal of biological chemistry 1989;264(11):6052-7.
1989: J P Klarnet; D E Kern; Steven K Dower; L A Matis; Martin A Cheever; Philip D Greenberg
Helper-independent CD8+ cytotoxic T lymphocytes express IL-1 receptors and require IL-1 for secretion of IL-2.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(7):2187-91.
1989: Elaine W Raines; Steven K Dower; Russell Ross
Interleukin-1 mitogenic activity for fibroblasts and smooth muscle cells is due to PDGF-AA.
Science (New York, N.Y.) 1989;243(4889):393-6.
1988: Eva E Qwarnstrom; R C Page; S Gillis; Steven K Dower
Binding, internalization, and intracellular localization of interleukin-1 beta in human diploid fibroblasts.
The Journal of biological chemistry 1988;263(17):8261-9.
1988: D L Urdal; S M Call; J L Jackson; Steven K Dower
Affinity purification and chemical analysis of the interleukin-1 receptor.
The Journal of biological chemistry 1988;263(6):2870-7.
1987: B Mosley; D L Urdal; K S Prickett; A Larsen; David Cosman; P J Conlon; S Gillis; Steven K Dower
The interleukin-1 receptor binds the human interleukin-1 alpha precursor but not the interleukin-1 beta precursor.
The Journal of biological chemistry 1987;262(7):2941-4.
1987: Steven K Dower; B Mosley; P J Conlon; P Benson; C Grubin; A Larsen; S Gillis; David Cosman
Molecular modification of lymphokines by in vitro mutagenesis.
Annals of the New York Academy of Sciences 1987;507():22-31.
1986: Steven K Dower; S R Kronheim; T P Hopp; M Cantrell; M Deeley; S Gillis; C S Henney; D L Urdal
The cell surface receptors for interleukin-1 alpha and interleukin-1 beta are identical.
Nature 1986;324(6094):266-8.
1986: S Gillis; P J Conlon; David Cosman; T P Hopp; Steven K Dower; V Price; D Y Mochizuki; D L Urdal
Lymphokines: from conjecture to the clinic.
Seminars in oncology 1986;13(2):218-27.
1986: Steven K Dower; S M Call; S Gillis; D L Urdal
Similarity between the interleukin 1 receptors on a murine T-lymphoma cell line and on a murine fibroblast cell line.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(4):1060-4.
1985: Steven K Dower; S R Kronheim; CJ March; P J Conlon; T P Hopp; S Gillis; D L Urdal
Detection and characterization of high affinity plasma membrane receptors for human interleukin 1.
The Journal of experimental medicine 1985;162(2):501-15.