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William Dowhan

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William Dowhan
A retrospective: use of Escherichia coli as a vehicle to study phospholipid synthesis and function.
Heidi Vitrac; Mikhail Bogdanov; William Dowhan
Proper fatty acid composition rather than an ionizable lipid amine is required for full transport function of lactose permease from Escherichia coli.
Soledad Bazán; Philip Heacock; Venkata K P S Mallampalli; Eugenia Mileykovskaya; Genevieve C Sparagna; William Dowhan
Cardiolipin-dependent reconstitution of respiratory supercomplexes from purified Saccharomyces cerevisiae complexes III and IV.

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All Publications

2013: William Dowhan
A retrospective: use of Escherichia coli as a vehicle to study phospholipid synthesis and function.
Biochimica et biophysica acta 2013;1831(3):471-94.
2013: Heidi Vitrac; Mikhail Bogdanov; William Dowhan
Proper fatty acid composition rather than an ionizable lipid amine is required for full transport function of lactose permease from Escherichia coli.
The Journal of biological chemistry 2013;288(8):5873-85.
2013: Soledad Bazán; Philip Heacock; Venkata K P S Mallampalli; Eugenia Mileykovskaya; Genevieve C Sparagna; William Dowhan
Cardiolipin-dependent reconstitution of respiratory supercomplexes from purified Saccharomyces cerevisiae complexes III and IV.
The Journal of biological chemistry 2013;288(1):401-11.
2012: Mikhail Bogdanov; William Dowhan
Lipid-dependent generation of dual topology for a membrane protein.
The Journal of biological chemistry 2012;287(45):37939-48.
2012: Eugenia Mileykovskaya; Pawel A Penczek; Genevieve C Sparagna; Jia Fang; Venkata K P S Mallampalli; William Dowhan
Arrangement of the respiratory chain complexes in Saccharomyces cerevisiae supercomplex III2IV2 revealed by single particle cryo-electron microscopy.
The Journal of biological chemistry 2012;287(27):23095-103.
2012: William Dowhan
The Raetz pathway for lipid A biosynthesis: Christian Rudolf Hubert Raetz, M.D., PH.D. 1946-2011.
Glycobiology 2012;22(1):3-6.
2011: William Dowhan
The Raetz pathway for lipid A biosynthesis: Christian Rudolf Hubert Raetz, MD PhD, 1946–2011.
Journal of lipid research 2011;52(11):1857-1860.
2011: Ji Zhang; Ziqiang Guan; Anne N Murphy; Sandra E Wiley; Guy A Perkins; Carolyn A Worby; James L Engel; Philip Heacock; Oanh Kim Nguyen; Jonathan H Wang; Christian R H Raetz; William Dowhan; Jack E Dixon
Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis.
Cell metabolism 2011;13(6):690-700.
2011: William Dowhan; Mikhail Bogdanov
Lipid-protein interactions as determinants of membrane protein structure and function.
Biochemical Society transactions 2011;39(3):767-74.
2011: Heidi Vitrac; Mikhail Bogdanov; Philip Heacock; William Dowhan
Lipids and topological rules of membrane protein assembly: balance between long and short range lipid-protein interactions.
The Journal of biological chemistry 2011;286(17):15182-94.
2011: Mani Chopra; David E Dostal; William Dowhan; Honey B Golden; Srinivas Mullapudi; Avadhesh C Sharma
Modulation of myocardial mitochondrial mechanisms during severe polymicrobial sepsis in the rat.
PloS one 2011;6(6):e21285.
2010: Mikhail Bogdanov; Philip Heacock; Ziqiang Guan; William Dowhan
Plasticity of lipid-protein interactions in the function and topogenesis of the membrane protein lactose permease from Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(34):15057-62.
2010: Mikhail Bogdanov; Philip N Heacock; William Dowhan
Study of polytopic membrane protein topological organization as a function of membrane lipid composition.
Methods in molecular biology (Clifton, N.J.) 2010;619():79-101.
2010: Maren Schniederberend; Petra Zimmann; Mikhail Bogdanov; William Dowhan; Karlheinz Altendorf
Influence of K+-dependent membrane lipid composition on the expression of the kdpFABC operon in Escherichia coli.
Biochimica et biophysica acta 2010;1798(1):32-9.
2009: Eugenia Mileykovskaya; William Dowhan
Cardiolipin membrane domains in prokaryotes and eukaryotes.
Biochimica et biophysica acta 2009;1788(10):2084-91.
2009: Tushar K Beuria; Srinivas Mullapudi; Eugenia Mileykovskaya; Mahalakshmi Sadasivam; William Dowhan; William Margolin
Adenine nucleotide-dependent regulation of assembly of bacterial tubulin-like FtsZ by a hypermorph of bacterial actin-like FtsA.
The Journal of biological chemistry 2009;284(21):14079-86.
2009: Mikhail Bogdanov; Jun Xie; William Dowhan
Lipid-protein interactions drive membrane protein topogenesis in accordance with the positive inside rule.
The Journal of biological chemistry 2009;284(15):9637-41.
2009: William Dowhan
Molecular genetic approaches to defining lipid function.
Journal of lipid research 2009;50 Suppl():S305-10.
2009: Eugenia Mileykovskaya; Andrea C Ryan; Xi Mo; Chun-Chieh Lin; Khaled I Khalaf; William Dowhan; Teresa A Garrett
Phosphatidic acid and N-acylphosphatidylethanolamine form membrane domains in Escherichia coli mutant lacking cardiolipin and phosphatidylglycerol.
The Journal of biological chemistry 2009;284(5):2990-3000.
2009: Malin Wikström; Amelie A Kelly; Alexander Georgiev; Hanna M Eriksson; Maria Rosén Klement; Mikhail Bogdanov; William Dowhan; Ake Wieslander
Lipid-engineered Escherichia coli membranes reveal critical lipid headgroup size for protein function.
The Journal of biological chemistry 2009;284(2):954-65.
2009: William Dowhan; Mikhail Bogdanov
Lipid-dependent membrane protein topogenesis.
Annual review of biochemistry 2009;78():515-40.
2008: Stephan Kutik; Michael Rissler; Xueli Guan; bernard guiard; Guanghou Shui; Natalia Gebert; Philip N Heacock; Peter Rehling; William Dowhan; Markus R Wenk; Nikolaus Pfanner; Nils Wiedemann
The translocator maintenance protein Tam41 is required for mitochondrial cardiolipin biosynthesis.
The Journal of cell biology 2008;183(7):1213-21.
2008: Shirley Mazor; Tomer Regev; Eugenia Mileykovskaya; William Margolin; William Dowhan; Itzhak Fishov
Mutual effects of MinD-membrane interaction: I. Changes in the membrane properties induced by MinD binding.
Biochimica et biophysica acta 2008;1778(11):2496-504.
2008: Shirley Mazor; Tomer Regev; Eugenia Mileykovskaya; William Margolin; William Dowhan; Itzhak Fishov
Mutual effects of MinD-membrane interaction: II. Domain structure of the membrane enhances MinD binding.
Biochimica et biophysica acta 2008;1778(11):2505-11.
2008: Mikhail Bogdanov; Jun Xie; Philip Heacock; William Dowhan
To flip or not to flip: lipid-protein charge interactions are a determinant of final membrane protein topology.
The Journal of cell biology 2008;182(5):925-35.
2008: Mikhail Bogdanov; Eugenia Mileykovskaya; William Dowhan
Lipids in the assembly of membrane proteins and organization of protein supercomplexes: implications for lipid-linked disorders.
Sub-cellular biochemistry 2008;49():197-239.
2006: Jun Xie; Mikhail Bogdanov; Philip Heacock; William Dowhan
Phosphatidylethanolamine and monoglucosyldiacylglycerol are interchangeable in supporting topogenesis and function of the polytopic membrane protein lactose permease.
The Journal of biological chemistry 2006;281(28):19172-8.
2006: Xuefeng Su; William Dowhan
Regulation of cardiolipin synthase levels in Saccharomyces cerevisiae.
Yeast (Chichester, England) 2006;23(4):279-91.
2006: Xuefeng Su; William Dowhan
Translational regulation of nuclear gene COX4 expression by mitochondrial content of phosphatidylglycerol and cardiolipin in Saccharomyces cerevisiae.
Molecular and cellular biology 2006;26(3):743-53.
2005: Yonit Tsatskis; Jumana Khambati; Martina Dobson; Mikhail Bogdanov; William Dowhan; Janet M Wood
The osmotic activation of transporter ProP is tuned by both its C-terminal coiled-coil and osmotically induced changes in phospholipid composition.
The Journal of biological chemistry 2005;280(50):41387-94.
2005: Mei Zhang; Eugenia Mileykovskaya; William Dowhan
Cardiolipin is essential for organization of complexes III and IV into a supercomplex in intact yeast mitochondria.
The Journal of biological chemistry 2005;280(33):29403-8.
2005: Wei Zhang; Heidi A Campbell; Steven C King; William Dowhan
Phospholipids as determinants of membrane protein topology. Phosphatidylethanolamine is required for the proper topological organization of the gamma-aminobutyric acid permease (GabP) of Escherichia coli.
The Journal of biological chemistry 2005;280(28):26032-8.
2005: Mikhail Bogdanov; Wei Zhang; Jun Xie; William Dowhan
Transmembrane protein topology mapping by the substituted cysteine accessibility method (SCAM(TM)): application to lipid-specific membrane protein topogenesis.
Methods (San Diego, Calif.) 2005;36(2):148-71.
2005: Eugenia Mileykovskaya; William Dowhan
Role of membrane lipids in bacterial division-site selection.
Current opinion in microbiology 2005;8(2):135-42.
2005: Silvia Vaena de Avalos; Xuefeng Su; Mei Zhang; Yasuo Okamoto; William Dowhan; Yusuf A Hannun
The phosphatidylglycerol/cardiolipin biosynthetic pathway is required for the activation of inositol phosphosphingolipid phospholipase C, Isc1p, during growth of Saccharomyces cerevisiae.
The Journal of biological chemistry 2005;280(8):7170-7.
2005: Eugenia Mileykovskaya; Mei Zhang; William Dowhan
Cardiolipin in energy transducing membranes.
Biochemistry. Biokhimii͡a 2005;70(2):154-8.
2004: William Dowhan; Eugenia Mileykovskaya; Mikhail Bogdanov
Diversity and versatility of lipid-protein interactions revealed by molecular genetic approaches.
Biochimica et biophysica acta 2004;1666(1-2):19-39.
2004: Malin Wikström; Jun Xie; Mikhail Bogdanov; Eugenia Mileykovskaya; Philip Heacock; Ake Wieslander; William Dowhan
Monoglucosyldiacylglycerol, a foreign lipid, can substitute for phosphatidylethanolamine in essential membrane-associated functions in Escherichia coli.
The Journal of biological chemistry 2004;279(11):10484-93.
2003: Wei Zhang; Mikhail Bogdanov; Jing Pi; A James Pittard; William Dowhan
Reversible topological organization within a polytopic membrane protein is governed by a change in membrane phospholipid composition.
The Journal of biological chemistry 2003;278(50):50128-35.
2003: Mei Zhang; Xuefeng Su; Eugenia Mileykovskaya; Andrew A Amoscato; William Dowhan
Cardiolipin is not required to maintain mitochondrial DNA stability or cell viability for Saccharomyces cerevisiae grown at elevated temperatures.
The Journal of biological chemistry 2003;278(37):35204-10.
2003: Shoshana Rozner; Sofiya Kolusheva; Zvi Cohen; William Dowhan; Jerry Eichler; Raz Jelinek
Detection and analysis of membrane interactions by a biomimetic colorimetric lipid/polydiacetylene assay.
Analytical biochemistry 2003;319(1):96-104.
2003: Eugenia Mileykovskaya; Itzhak Fishov; Xueyao Fu; Brian D Corbin; William Margolin; William Dowhan
Effects of phospholipid composition on MinD-membrane interactions in vitro and in vivo.
The Journal of biological chemistry 2003;278(25):22193-8.
2002: Jeanie B McMillin; William Dowhan
Cardiolipin and apoptosis.
Biochimica et biophysica acta 2002;1585(2-3):97-107.
2002: Mei Zhang; Eugenia Mileykovskaya; William Dowhan
Gluing the respiratory chain together. Cardiolipin is required for supercomplex formation in the inner mitochondrial membrane.
The Journal of biological chemistry 2002;277(46):43553-6.
2002: Xiaoyuan Wang; Mikhail Bogdanov; William Dowhan
Topology of polytopic membrane protein subdomains is dictated by membrane phospholipid composition.
The EMBO journal 2002;21(21):5673-81.
2002: Mikhail Bogdanov; Philip Heacock; William Dowhan
A polytopic membrane protein displays a reversible topology dependent on membrane lipid composition.
The EMBO journal 2002;21(9):2107-16.
2001: Eugenia Mileykovskaya; William Dowhan; R L Birke; D Zheng; L Lutterodt; T H Haines
Cardiolipin binds nonyl acridine orange by aggregating the dye at exposed hydrophobic domains on bilayer surfaces.
FEBS letters 2001;507(2):187-90.
2001: Darin Bruce Ostrander; Genevieve C Sparagna; Andrew A Amoscato; Jeanie B McMillin; William Dowhan
Decreased cardiolipin synthesis corresponds with cytochrome c release in palmitate-induced cardiomyocyte apoptosis.
The Journal of biological chemistry 2001;276(41):38061-7.
2001: Darin Bruce Ostrander; Mei Zhang; Eugenia Mileykovskaya; M Rho; William Dowhan
Lack of mitochondrial anionic phospholipids causes an inhibition of translation of protein components of the electron transport chain. A yeast genetic model system for the study of anionic phospholipid function in mitochondria.
The Journal of biological chemistry 2001;276(27):25262-72.
2000: Eugenia Mileykovskaya; William Dowhan
Visualization of phospholipid domains in Escherichia coli by using the cardiolipin-specific fluorescent dye 10-N-nonyl acridine orange.
Journal of bacteriology 2000;182(4):1172-5.
1999: Mikhail Bogdanov; William Dowhan
Lipid-assisted protein folding.
The Journal of biological chemistry 1999;274(52):36827-30.
1999: Mikhail Bogdanov; M Umeda; William Dowhan
Phospholipid-assisted refolding of an integral membrane protein. Minimum structural features for phosphatidylethanolamine to act as a molecular chaperone.
The Journal of biological chemistry 1999;274(18):12339-45.
1999: Kiyoshi Kawasaki; Osamu Kuge; SC Chang; Philip Heacock; M Rho; Koichi Suzuki; Masahiro Nishijima; William Dowhan
Isolation of a chinese hamster ovary (CHO) cDNA encoding phosphatidylglycerophosphate (PGP) synthase, expression of which corrects the mitochondrial abnormalities of a PGP synthase-defective mutant of CHO-K1 cells.
The Journal of biological chemistry 1999;274(3):1828-34.
1998: William Dowhan
Genetic analysis of lipid-protein interactions in Escherichia coli membranes.
Biochimica et biophysica acta 1998;1376(3):455-66.
1998: Mikhail Bogdanov; William Dowhan
Phospholipid-assisted protein folding: phosphatidylethanolamine is required at a late step of the conformational maturation of the polytopic membrane protein lactose permease.
The EMBO journal 1998;17(18):5255-64.
1998: Eugenia Mileykovskaya; Qin Sun; William Margolin; William Dowhan
Localization and function of early cell division proteins in filamentous Escherichia coli cells lacking phosphatidylethanolamine.
Journal of bacteriology 1998;180(16):4252-7.
1998: SC Chang; Philip Heacock; Eugenia Mileykovskaya; D R Voelker; William Dowhan
Isolation and characterization of the gene (CLS1) encoding cardiolipin synthase in Saccharomyces cerevisiae.
The Journal of biological chemistry 1998;273(24):14933-41.
1998: H Shen; William Dowhan
Regulation of phosphatidylglycerophosphate synthase levels in Saccharomyces cerevisiae.
The Journal of biological chemistry 1998;273(19):11638-42.
1998: SC Chang; Philip Heacock; CJ Clancey; William Dowhan
The PEL1 gene (renamed PGS1) encodes the phosphatidylglycero-phosphate synthase of Saccharomyces cerevisiae.
The Journal of biological chemistry 1998;273(16):9829-36.
1997: William Dowhan
CDP-diacylglycerol synthase of microorganisms.
Biochimica et biophysica acta 1997;1348(1-2):157-65.
1997: H Shen; William Dowhan
Regulation of phospholipid biosynthetic enzymes by the level of CDP-diacylglycerol synthase activity.
The Journal of biological chemistry 1997;272(17):11215-20.
1997: Eugenia Mileykovskaya; William Dowhan
The Cpx two-component signal transduction pathway is activated in Escherichia coli mutant strains lacking phosphatidylethanolamine.
Journal of bacteriology 1997;179(4):1029-34.
1997: William Dowhan
Molecular basis for membrane phospholipid diversity: why are there so many lipids?
Annual review of biochemistry 1997;66():199-232.
1997: William Dowhan
Phosphatidylserine decarboxylases: pyruvoyl-dependent enzymes from bacteria to mammals.
Methods in enzymology 1997;280():81-8.
1996: H Shen; William Dowhan
Reduction of CDP-diacylglycerol synthase activity results in the excretion of inositol by Saccharomyces cerevisiae.
The Journal of biological chemistry 1996;271(46):29043-8.
1996: Mikhail Bogdanov; Jason Sun; H R Kaback; William Dowhan
A phospholipid acts as a chaperone in assembly of a membrane transport protein.
The Journal of biological chemistry 1996;271(20):11615-8.
1996: S C Dryden; William Dowhan
Isolation and expression of the Rhodobacter sphaeroides gene (pgsA) encoding phosphatidylglycerophosphate synthase.
Journal of bacteriology 1996;178(4):1030-8.
1996: H Shen; Philip Heacock; C J Clancey; William Dowhan
The CDS1 gene encoding CDP-diacylglycerol synthase in Saccharomyces cerevisiae is essential for cell growth.
The Journal of biological chemistry 1996;271(2):789-95.
1995: W Xia; William Dowhan
Phosphatidylinositol cannot substitute for phosphatidylglycerol in supporting cell growth of Escherichia coli.
Journal of bacteriology 1995;177(10):2926-8.
1995: W Xia; William Dowhan
In vivo evidence for the involvement of anionic phospholipids in initiation of DNA replication in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(3):783-7.
1995: Mikhail Bogdanov; William Dowhan
Phosphatidylethanolamine is required for in vivo function of the membrane-associated lactose permease of Escherichia coli.
The Journal of biological chemistry 1995;270(2):732-9.
1993: W Shi; M Bogdanov; William Dowhan; David R Zusman
The pss and psd genes are required for motility and chemotaxis in Escherichia coli.
Journal of bacteriology 1993;175(23):7711-4.
1993: Eugenia Mileykovskaya; William Dowhan
Alterations in the electron transfer chain in mutant strains of Escherichia coli lacking phosphatidylethanolamine.
The Journal of biological chemistry 1993;268(33):24824-31.
1993: C J Clancey; S C Chang; William Dowhan
Cloning of a gene (PSD1) encoding phosphatidylserine decarboxylase from Saccharomyces cerevisiae by complementation of an Escherichia coli mutant.
The Journal of biological chemistry 1993;268(33):24580-90.
1992: William Dowhan; Q X Li
Phosphatidylserine decarboxylase from Escherichia coli.
Methods in enzymology 1992;209():348-59.
1992: William Dowhan; C R Funk
Phosphatidylglycerophosphate phosphatase from Escherichia coli.
Methods in enzymology 1992;209():224-30.
1992: C R Funk; L Zimniak; William Dowhan
The pgpA and pgpB genes of Escherichia coli are not essential: evidence for a third phosphatidylglycerophosphate phosphatase.
Journal of bacteriology 1992;174(1):205-13.
1991: William Dowhan
Phospholipid-transfer proteins.
Current opinion in cell biology 1991;3(4):621-5.
1991: A DeChavigny; Philip Heacock; William Dowhan
Sequence and inactivation of the pss gene of Escherichia coli. Phosphatidylethanolamine may not be essential for cell viability.
The Journal of biological chemistry 1991;266(16):10710.
1991: A DeChavigny; Philip Heacock; William Dowhan
Sequence and inactivation of the pss gene of Escherichia coli. Phosphatidylethanolamine may not be essential for cell viability.
The Journal of biological chemistry 1991;266(8):5323-32.
1990: J F Aitken; G P van Heusden; M Temkin; William Dowhan
The gene encoding the phosphatidylinositol transfer protein is essential for cell growth.
The Journal of biological chemistry 1990;265(8):4711-7.
1990: Q X Li; William Dowhan
Studies on the mechanism of formation of the pyruvate prosthetic group of phosphatidylserine decarboxylase from Escherichia coli.
The Journal of biological chemistry 1990;265(7):4111-5.
1989: Philip Heacock; William Dowhan
Alteration of the phospholipid composition of Escherichia coli through genetic manipulation.
The Journal of biological chemistry 1989;264(25):14972-7.
1988: Q X Li; William Dowhan
Structural characterization of Escherichia coli phosphatidylserine decarboxylase.
The Journal of biological chemistry 1988;263(23):11516-22.
1987: Philip Heacock; William Dowhan
Construction of a lethal mutation in the synthesis of the major acidic phospholipids of Escherichia coli.
The Journal of biological chemistry 1987;262(27):13044-9.
1986: A S Gopalakrishnan; Y C Chen; M Temkin; William Dowhan
Structure and expression of the gene locus encoding the phosphatidylglycerophosphate synthase of Escherichia coli.
The Journal of biological chemistry 1986;261(3):1329-38.
1982: SD Tucker; A S Gopalakrishnan; R Bollinger; William Dowhan; Emanuel J Murgola
Molecular mapping of glyW, a duplicate gene for tRNA3Gly of Escherichia coli.
Journal of bacteriology 1982;152(2):773-9.