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Peter Downes

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Helene Maccario; Nevin M Perera; Alexander Gray; C Peter Downes; Nick R Leslie
Ubiquitination of PTEN (phosphatase and tensin homolog) inhibits phosphatase activity and is enhanced by membrane targeting and hyperosmotic stress.
Lindsay Davidson; H Maccario; N M Perera; X Yang; L Spinelli; P Tibarewal; B Glancy; A Gray; C J Weijer; C Peter Downes; Nick R Leslie
Suppression of cellular proliferation and invasion by the concerted lipid and protein phosphatase activities of PTEN.
Nick R Leslie; Laura Spinelli; Priyanka Tibarewal; Georgios Zilidis; Nimmi Weerasinghe; Joseph C Lim; Helene Maccario; C Peter Downes
Indirect mechanisms of carcinogenesis via downregulation of PTEN function.

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2010: Helene Maccario; Nevin M Perera; Alexander Gray; C Peter Downes; Nick R Leslie
Ubiquitination of PTEN (phosphatase and tensin homolog) inhibits phosphatase activity and is enhanced by membrane targeting and hyperosmotic stress.
The Journal of biological chemistry 2010;285(17):12620-8.
2010: Lindsay Davidson; H Maccario; N M Perera; X Yang; L Spinelli; P Tibarewal; B Glancy; A Gray; C J Weijer; C Peter Downes; Nick R Leslie
Suppression of cellular proliferation and invasion by the concerted lipid and protein phosphatase activities of PTEN.
Oncogene 2010;29(5):687-97.
2010: Nick R Leslie; Laura Spinelli; Priyanka Tibarewal; Georgios Zilidis; Nimmi Weerasinghe; Joseph C Lim; Helene Maccario; C Peter Downes
Indirect mechanisms of carcinogenesis via downregulation of PTEN function.
Advances in enzyme regulation 2010;50(1):112-8.
2009: Usha Padmanabhan; D Eric Dollins; Peter C Fridy; John D York; C Peter Downes
Characterization of a selective inhibitor of inositol hexakisphosphate kinases: use in defining biological roles and metabolic relationships of inositol pyrophosphates.
The Journal of biological chemistry 2009;284(16):10571-82.
2008: Nick R Leslie; Ian H Batty; H Maccario; Lindsay Davidson; C Peter Downes
Understanding PTEN regulation: PIP2, polarity and protein stability.
Oncogene 2008;27(41):5464-76.
2008: Ben Hale; Ian H Batty; C Peter Downes; Richard E Randall
Binding of influenza A virus NS1 protein to the inter-SH2 domain of p85 suggests a novel mechanism for phosphoinositide 3-kinase activation.
The Journal of biological chemistry 2008;283(3):1372-80.
2007: J Lackey; J Barnett; Lindsay Davidson; Ian H Batty; Nick R Leslie; C Peter Downes
Loss of PTEN selectively desensitizes upstream IGF1 and insulin signaling.
Oncogene 2007;26(50):7132-42.
2007: Ian H Batty; Jeroen van der Kaay; Alex Gray; Joan F Telfer; Miles J Dixon; C Peter Downes
The control of phosphatidylinositol 3,4-bisphosphate concentrations by activation of the Src homology 2 domain containing inositol polyphosphate 5-phosphatase 2, SHIP2.
The Biochemical journal 2007;407(2):255-66.
2007: Helene Maccario; Nevin M Perera; Lindsay Davidson; C Peter Downes; Nick R Leslie
PTEN is destabilized by phosphorylation on Thr366.
The Biochemical journal 2007;405(3):439-44.
2007: Sarah H Ross; Yvonne Lindsay; Steve Safrany; Oscar Lorenzo; Fabrizio Villa; Rachel Toth; Michael J Clague; C Peter Downes; Nick R Leslie
Differential redox regulation within the PTP superfamily.
Cellular signalling 2007;19(7):1521-30.
2007: C Peter Downes; Nick R Leslie; Ian H Batty; Jeroen van der Kaay
Metabolic switching of PI3K-dependent lipid signals.
Biochemical Society transactions 2007;35(Pt 2):188-92.
2007: Nick R Leslie; Xuesong Yang; C Peter Downes; Cornelis J Weijer
PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration.
Current biology : CB 2007;17(2):115-25.
2007: C Peter Downes; Sarah Ross; Helene Maccario; Nevin M Perera; Lindsay Davidson; Nick R Leslie
Stimulation of PI 3-kinase signaling via inhibition of the tumor suppressor phosphatase, PTEN.
Advances in enzyme regulation 2007;47():184-94.
2007: C Peter Downes; Nevin M Perera; Sarah Ross; Nick R Leslie
Substrate specificity and acute regulation of the tumour suppressor phosphatase, PTEN.
Biochemical Society symposium 2007;(74):69-80.
2006: Yvonne Lindsay; David McCoull; Lindsay Davidson; Nick R Leslie; Alison Fairservice; Alex Gray; John M Lucocq; C Peter Downes
Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression.
Journal of cell science 2006;119(Pt 24):5160-8.
2006: Ke Ning; Lisa C Miller; Hilary A Laidlaw; Laura A Burgess; Nevin M Perera; C Peter Downes; Nick R Leslie; Michael L J Ashford
A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic beta-cells.
The EMBO journal 2006;25(11):2377-87.
2005: Nick R Leslie; X Yang; C Peter Downes; Cornelis J Weijer
The regulation of cell migration by PTEN.
Biochemical Society transactions 2005;33(Pt 6):1507-8.
2005: C Peter Downes; Alex Gray; Alison Fairservice; Steve Safrany; Ian H Batty; I Fleming
The regulation of membrane to cytosol partitioning of signalling proteins by phosphoinositides and their soluble headgroups.
Biochemical Society transactions 2005;33(Pt 6):1303-7.
2005: C Peter Downes; Alex Gray; John M Lucocq
Probing phosphoinositide functions in signaling and membrane trafficking.
Trends in cell biology 2005;15(5):259-68.
2004: Nick R Leslie; Yvonne Lindsay; S H Ross; C Peter Downes
Redox regulation of phosphatase function.
Biochemical Society transactions 2004;32(Pt 6):1018-20.
2004: Ian N Fleming; Ian H Batty; Alan R Prescott; Alex Gray; Gursant S Kular; Hazel Stewart; C Peter Downes
Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1.
The Biochemical journal 2004;382(Pt 3):857-65.
2004: Nick R Leslie; C Peter Downes
PTEN function: how normal cells control it and tumour cells lose it.
The Biochemical journal 2004;382(Pt 1):1-11.
2004: Laura S Harrington; Greg M Findlay; Alex Gray; Tatiana Tolkacheva; Simon Wigfield; Heike Rebholz; Jill Barnett; Nick R Leslie; Susan Cheng; Peter R Shepherd; Ivan T Gout; C Peter Downes; Richard F Lamb
The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins.
The Journal of cell biology 2004;166(2):213-23.
2004: Barbara A Spruce; Lorna A Campbell; Niall McTavish; Michelle A Cooper; M Virginia L Appleyard; Mary O'Neill; Jacqueline Howie; Jayne Samson; Stephen Watt; Karen Murray; Doris McLean; Nick R Leslie; Steve Safrany; Michelle J Ferguson; John A Peters; Alan R Prescott; Gary Box; Angela Hayes; Bernard P Nutley; Florence I Raynaud; C Peter Downes; Jeremy J Lambert; Alastair Thompson; Suzanne A Eccles
Small molecule antagonists of the sigma-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo.
Cancer research 2004;64(14):4875-86.
2004: Ian H Batty; Ian N Fleming; C Peter Downes
Muscarinic-receptor-mediated inhibition of insulin-like growth factor-1 receptor-stimulated phosphoinositide 3-kinase signalling in 1321N1 astrocytoma cells.
The Biochemical journal 2004;379(Pt 3):641-51.
2004: Steven M Walker; Nick R Leslie; Nevin M Perera; Ian H Batty; C Peter Downes
The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif.
The Biochemical journal 2004;379(Pt 2):301-7.
2004: C Peter Downes; S Walker; George McConnachie; Yvonne Lindsay; Ian H Batty; Nick R Leslie
Acute regulation of the tumour suppressor phosphatase, PTEN, by anionic lipids and reactive oxygen species.
Biochemical Society transactions 2004;32(Pt 2):338-42.
2004: Stephen A Watt; Wendy A Kimber; Ian N Fleming; Nick R Leslie; C Peter Downes; John M Lucocq
Detection of novel intracellular agonist responsive pools of phosphatidylinositol 3,4-bisphosphate using the TAPP1 pleckstrin homology domain in immunoelectron microscopy.
The Biochemical journal 2004;377(Pt 3):653-63.
2004: Elaine A Orchiston; Deborah Bennett; Nick R Leslie; Rosemary G Clarke; Lucinda Winward; C Peter Downes; Steve Safrany
PTEN M-CBR3, a versatile and selective regulator of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5). Evidence for Ins(1,3,4,5,6)P5 as a proliferative signal.
The Journal of biological chemistry 2004;279(2):1116-22.
2003: Nick R Leslie; Deborah Bennett; Yvonne Lindsay; Hazel Stewart; Alex Gray; C Peter Downes
Redox regulation of PI 3-kinase signalling via inactivation of PTEN.
The EMBO journal 2003;22(20):5501-10.
2003: Johanne Bentley; Dalina Itchayanan; Kay Barnes; Elizabeth McIntosh; Xiuwen Tang; C Peter Downes; Geoffrey D Holman; Anthony D Whetton; P Jane Owen-Lynch; Stephen A Baldwin
Interleukin-3-mediated cell survival signals include phosphatidylinositol 3-kinase-dependent translocation of the glucose transporter GLUT1 to the cell surface.
The Journal of biological chemistry 2003;278(41):39337-48.
2003: Xiuwen Tang; Lijun Wang; Christopher G Proud; C Peter Downes
Muscarinic receptor-mediated activation of p70 S6 kinase 1 (S6K1) in 1321N1 astrocytoma cells: permissive role of phosphoinositide 3-kinase.
The Biochemical journal 2003;374(Pt 1):137-43.
2003: George McConnachie; Ian Pass; Steven M Walker; C Peter Downes
Interfacial kinetic analysis of the tumour suppressor phosphatase, PTEN: evidence for activation by anionic phospholipids.
The Biochemical journal 2003;371(Pt 3):947-55.
2003: C Peter Downes; Alex Gray; Stephen A Watt; John M Lucocq
Advances in procedures for the detection and localization of inositol phospholipid signals in cells, tissues, and enzyme assays.
Methods in enzymology 2003;366():64-84.
2002: Stephen A Watt; Gursant S Kular; Ian N Fleming; C Peter Downes; John M Lucocq
Subcellular localization of phosphatidylinositol 4,5-bisphosphate using the pleckstrin homology domain of phospholipase C delta1.
The Biochemical journal 2002;363(Pt 3):657-66.
2002: Nick R Leslie; C Peter Downes
PTEN: The down side of PI 3-kinase signalling.
Cellular signalling 2002;14(4):285-95.
2002: Thomas Radimerski; Jacques Montagne; Felix Rintelen; Hugo Stocker; Jeroen van der Kaay; C Peter Downes; Ernst Hafen; George Thomas
dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1.
Nature cell biology 2002;4(3):251-5.
2002: Wendy A Kimber; Laura Trinkle-Mulcahy; Peter C F Cheung; Maria Deak; Louisa J Marsden; Agnieszka Kieloch; Stephen Watt; Ronald T Javier; Alex Gray; C Peter Downes; John M Lucocq; Dario R Alessi
Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo.
The Biochemical journal 2002;361(Pt 3):525-36.
2002: Xiuwen Tang; Ian H Batty; C Peter Downes
Muscarinic receptors mediate phospholipase C-dependent activation of protein kinase B via Ca2+, ErbB3, and phosphoinositide 3-kinase in 1321N1 astrocytoma cells.
The Journal of biological chemistry 2002;277(1):338-44.
2001: Steven M Walker; C Peter Downes; Nick R Leslie
TPIP: a novel phosphoinositide 3-phosphatase.
The Biochemical journal 2001;360(Pt 2):277-83.
2001: C Peter Downes; Deborah Bennett; George McConnachie; Nick R Leslie; Ian Pass; Colin H Macphee; Lisa Patel; Alex Gray
Antagonism of PI 3-kinase-dependent signalling pathways by the tumour suppressor protein, PTEN.
Biochemical Society transactions 2001;29(Pt 6):846-51.
2001: E Hill; O Olusanya; Jeroen van der Kaay; C Peter Downes; Paul D Andrews; Jason R Swedlow; Elizabeth Smythe
Regulation of clathrin-coated vesicle formation.
Biochemical Society transactions 2001;29(Pt 4):375-7.
2001: Nick R Leslie; Deborah Bennett; Alex Gray; Ian Pass; K Hoang-Xuan; C Peter Downes
Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions.
The Biochemical journal 2001;357(Pt 2):427-35.
2001: Lisa Patel; Ian Pass; P Coxon; C Peter Downes; Stephen A Smith; Colin H Macphee
Tumor suppressor and anti-inflammatory actions of PPARgamma agonists are mediated via upregulation of PTEN.
Current biology : CB 2001;11(10):764-8.
2001: Eric Hajduch; A Balendran; Ian H Batty; Gary J Litherland; Anne Blair; C Peter Downes; Harinder S Hundal
Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells.
Diabetologia 2001;44(2):173-83.
2001: E Hill; Jeroen van der Kaay; C Peter Downes; Elizabeth Smythe
The role of dynamin and its binding partners in coated pit invagination and scission.
The Journal of cell biology 2001;152(2):309-23.
2000: DB Parekh; Roy M Katso; N R Leslie; C Peter Downes; Katarzyna Joanna Procyk; Michael D Waterfield; Peter J Parker
Beta1-integrin and PTEN control the phosphorylation of protein kinase C.
The Biochemical journal 2000;352 Pt 2():425-33.
2000: T Shinomura; E del Río; Kieran C Breen; C Peter Downes; M McLaughlin
Activation of phospholipase D by metabotropic glutamate receptor agonists in rat cerebrocortical synaptosomes.
British journal of pharmacology 2000;131(5):1011-8.
2000: Simon Dowler; RA Currie; David G Campbell; Maria Deak; Gursant S Kular; C Peter Downes; Dario R Alessi
Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities.
The Biochemical journal 2000;351(Pt 1):19-31.
2000: Ian N Fleming; Alex Gray; C Peter Downes
Regulation of the Rac1-specific exchange factor Tiam1 involves both phosphoinositide 3-kinase-dependent and -independent components.
The Biochemical journal 2000;351(Pt 1):173-82.
2000: Xiuwen Tang; C Peter Downes; Anthony D Whetton; P Jane Owen-Lynch
Role of phosphatidylinositol 3-kinase and specific protein kinase B isoforms in the suppression of apoptosis mediated by the Abelson protein-tyrosine kinase.
The Journal of biological chemistry 2000;275(17):13142-8.
2000: Nick R Leslie; Alex Gray; Ian Pass; E A Orchiston; C Peter Downes
Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinase.
The Biochemical journal 2000;346 Pt 3():827-33.
2000: Jenni Harvey; Neil G McKay; KS Walker; Jeroen van der Kaay; C Peter Downes; Michael L J Ashford
Essential role of phosphoinositide 3-kinase in leptin-induced K(ATP) channel activation in the rat CRI-G1 insulinoma cell line.
The Journal of biological chemistry 2000;275(7):4660-9.
1999: Alex Gray; Jeroen van der Kaay; C Peter Downes
The pleckstrin homology domains of protein kinase B and GRP1 (general receptor for phosphoinositides-1) are sensitive and selective probes for the cellular detection of phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 3,4,5-trisphosphate in vivo.
The Biochemical journal 1999;344 Pt 3():929-36.
1999: Jeroen van der Kaay; M Beck; Alex Gray; C Peter Downes
Distinct phosphatidylinositol 3-kinase lipid products accumulate upon oxidative and osmotic stress and lead to different cellular responses.
The Journal of biological chemistry 1999;274(50):35963-8.
1999: Simon Dowler; RA Currie; C Peter Downes; Dario R Alessi
DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides.
The Biochemical journal 1999;342 ( Pt 1)():7-12.
1999: S Ponnambalam; S Clough; C Peter Downes; John M Lucocq; Hilary McLauchlan; Mhairi C Towler
Lipid kinases and trans-Golgi network membrane dynamics.
Biochemical Society transactions 1999;27(4):670-3.
1999: Maria Deak; Antonio Casamayor; RA Currie; C Peter Downes; Dario R Alessi
Characterisation of a plant 3-phosphoinositide-dependent protein kinase-1 homologue which contains a pleckstrin homology domain.
FEBS letters 1999;451(3):220-6.
1999: Eric Hajduch; F Rencurel; A Balendran; Ian H Batty; C Peter Downes; Harinder S Hundal
Serotonin (5-Hydroxytryptamine), a novel regulator of glucose transport in rat skeletal muscle.
The Journal of biological chemistry 1999;274(19):13563-8.
1999: Ian N Fleming; CM Elliott; F Gregory Buchanan; C Peter Downes; John H Exton
Ca2+/calmodulin-dependent protein kinase II regulates Tiam1 by reversible protein phosphorylation.
The Journal of biological chemistry 1999;274(18):12753-8.
1999: A Balendran; Antonio Casamayor; Maria Deak; A Paterson; P Gaffney; R Currie; C Peter Downes; Dario R Alessi
PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.
Current biology : CB 1999;9(8):393-404.
1999: RA Currie; KS Walker; Alex Gray; Maria Deak; Antonio Casamayor; C Peter Downes; Philip Cohen; Dario R Alessi; John M Lucocq
Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1.
The Biochemical journal 1999;337 ( Pt 3)():575-83.
1998: Dario R Alessi; C Peter Downes
The role of PI 3-kinase in insulin action.
Biochimica et biophysica acta 1998;1436(1-2):151-64.
1998: C Peter Downes; RA Currie
Lipid signalling.
Current biology : CB 1998;8(24):R865-7.
1998: Michael P Myers; Ian Pass; Ian H Batty; Jeroen van der Kaay; JP Stolarov; B A Hemmings; Michael Wigler; C Peter Downes; Nicholas K Tonks
The lipid phosphatase activity of PTEN is critical for its tumor supressor function.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(23):13513-8.
1998: M V Ellis; SR James; Olga Perisic; C Peter Downes; Roger L Williams; Matilda Katan
Catalytic domain of phosphoinositide-specific phospholipase C (PLC). Mutational analysis of residues within the active site and hydrophobic ridge of plcdelta1.
The Journal of biological chemistry 1998;273(19):11650-9.
1998: H Banfić; C Peter Downes; Susan E Rittenhouse
Biphasic activation of PKBalpha/Akt in platelets. Evidence for stimulation both by phosphatidylinositol 3,4-bisphosphate, produced via a novel pathway, and by phosphatidylinositol 3,4,5-trisphosphate.
The Journal of biological chemistry 1998;273(19):11630-7.
1998: E del Río; T Shinomura; Jeroen van der Kaay; David G Nicholls; C Peter Downes
Disruption by lithium of phosphoinositide signalling in cerebellar granule cells in primary culture.
Journal of neurochemistry 1998;70(4):1662-9.
1998: Ian H Batty; RA Currie; C Peter Downes
Evidence for a model of integrated inositol phospholipid pools implies an essential role for lipid transport in the maintenance of receptor-mediated phospholipase C activity in 1321N1 cells.
The Biochemical journal 1998;330 ( Pt 3)():1069-77.
1998: H Banfić; X Tang; Ian H Batty; C Peter Downes; C Chen; Susan E Rittenhouse
A novel integrin-activated pathway forms PKB/Akt-stimulatory phosphatidylinositol 3,4-bisphosphate via phosphatidylinositol 3-phosphate in platelets.
The Journal of biological chemistry 1998;273(1):13-6.
1998: Jeroen van der Kaay; P J Cullen; C Peter Downes
Phosphatidylinositol(3,4,5)trisphosphate (Ptdins(3,4,5)P3) mass measurement using a radioligand displacement assay.
Methods in molecular biology (Clifton, N.J.) 1998;105():109-25.
1997: D M Hickinson; John M Lucocq; Mhairi C Towler; S Clough; J James; SR James; C Peter Downes; S Ponnambalam
Association of a phosphatidylinositol-specific 3-kinase with a human trans-Golgi network resident protein.
Current biology : CB 1997;7(12):987-90.
1997: Ian H Batty; D M Hickinson; C Peter Downes
Cross-talk between phospholipase C and phosphoinositide 3-kinase signalling pathways.
Biochemical Society transactions 1997;25(4):1132-7.
1997: SR James; C Peter Downes
Structural and mechanistic features of phospholipases C: effectors of inositol phospholipid-mediated signal transduction.
Cellular signalling 1997;9(5):329-36.
1997: HE McDowell; T Walker; Eric Hajduch; Graham R Christie; Ian H Batty; C Peter Downes; Harinder S Hundal
Inositol phospholipid 3-kinase is activated by cellular stress but is not required for the stress-induced activation of glucose transport in L6 rat skeletal muscle cells.
European journal of biochemistry / FEBS 1997;247(1):306-13.
1997: Xiuwen Tang; C Peter Downes
Purification and characterization of Gbetagamma-responsive phosphoinositide 3-kinases from pig platelet cytosol.
The Journal of biological chemistry 1997;272(22):14193-9.
1997: Darren A E Cross; Peter W Watt; M Shaw; Jeroen van der Kaay; C Peter Downes; Julie C Holder; Philip Cohen
Insulin activates protein kinase B, inhibits glycogen synthase kinase-3 and activates glycogen synthase by rapamycin-insensitive pathways in skeletal muscle and adipose tissue.
FEBS letters 1997;406(1-2):211-5.
1997: Dario R Alessi; SR James; C Peter Downes; Andrew B Holmes; PR Gaffney; CB Reese; Philip Cohen
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha.
Current biology : CB 1997;7(4):261-9.
1997: RA Currie; B M MacLeod; C Peter Downes
The lipid transfer activity of phosphatidylinositol transfer protein is sufficient to account for enhanced phospholipase C activity in turkey erythrocyte ghosts.
Current biology : CB 1997;7(3):184-90.
1997: Jeroen van der Kaay; Ian H Batty; Darren A E Cross; Peter W Watt; C Peter Downes
A novel, rapid, and highly sensitive mass assay for phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) and its application to measure insulin-stimulated PtdIns(3,4,5)P3 production in rat skeletal muscle in vivo.
The Journal of biological chemistry 1997;272(9):5477-81.
1997: SR James; A Paterson; T Kendall Harden; R A Demel; C Peter Downes
Dependence of the activity of phospholipase C beta on surface pressure and surface composition in phospholipid monolayers and its implications for their regulation.
Biochemistry 1997;36(4):848-55.
1996: Ian H Batty; C Peter Downes
Thrombin receptors modulate insulin-stimulated phosphatidylinositol 3,4,5-trisphosphate accumulation in 1321N1 astrocytoma cells.
The Biochemical journal 1996;317 ( Pt 2)():347-51.
1996: SR James; C Peter Downes; R Gigg; S J Grove; Andrew B Holmes; Dario R Alessi
Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation.
The Biochemical journal 1996;315 ( Pt 3)():709-13.
1996: SR James; S Smith; A Paterson; T Kendall Harden; C Peter Downes
Time-dependent inhibition of phospholipase C beta-catalysed phosphoinositide hydrolysis: a comparison of different assays.
The Biochemical journal 1996;314 ( Pt 3)():917-21.
1995: J A Bevilacqua; C Peter Downes; Pedro R Lowenstein
Transiently selective activation of phosphoinositide turnover in layer V pyramidal neurons after specific mGluRs stimulation in rat somatosensory cortex during early postnatal development.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(12):7916-28.
1995: R M Baxter; Philip Cohen; A Obermeier; A Ullrich; C Peter Downes; Y N Doza
Phosphotyrosine residues in the nerve-growth-factor receptor (Trk-A). Their role in the activation of inositolphospholipid metabolism and protein kinase cascades in phaeochromocytoma (PC12) cells.
European journal of biochemistry / FEBS 1995;234(1):84-91.
1995: Ian H Batty; C Peter Downes
The mechanism of muscarinic receptor-stimulated phosphatidylinositol resynthesis in 1321N1 astrocytoma cells and its inhibition by Li+.
Journal of neurochemistry 1995;65(5):2279-89.
1995: T Tsakiridis; H E McDowell; T Walker; C Peter Downes; Harinder S Hundal; Mladen Vranic; Amira Klip
Multiple roles of phosphatidylinositol 3-kinase in regulation of glucose transport, amino acid transport, and glucose transporters in L6 skeletal muscle cells.
Endocrinology 1995;136(10):4315-22.
1995: SR James; A Paterson; T Kendall Harden; C Peter Downes
Kinetic analysis of phospholipase C beta isoforms using phospholipid-detergent mixed micelles. Evidence for interfacial catalysis involving distinct micelle binding and catalytic steps.
The Journal of biological chemistry 1995;270(20):11872-81.
1994: SR James; Cyrus Vaziri; T R Walker; G Milligan; C Peter Downes
The turkey erythrocyte beta-adrenergic receptor couples to both adenylate cyclase and phospholipase C via distinct G-protein alpha subunits.
The Biochemical journal 1994;304 ( Pt 2)():359-64.
1994: F Estevez; D Pulford; Michael J R Stark; A N Carter; C Peter Downes
Inositol trisphosphate metabolism in Saccharomyces cerevisiae: identification, purification and properties of inositol 1,4,5-trisphosphate 6-kinase.
The Biochemical journal 1994;302 ( Pt 3)():709-16.
1994: E del Río; David G Nicholls; C Peter Downes
Involvement of calcium influx in muscarinic cholinergic regulation of phospholipase C in cerebellar granule cells.
Journal of neurochemistry 1994;63(2):535-43.
1994: A N Carter; R Huang; A Sorisky; C Peter Downes; Susan E Rittenhouse
Phosphatidylinositol 3,4,5-trisphosphate is formed from phosphatidylinositol 4,5-bisphosphate in thrombin-stimulated platelets.
The Biochemical journal 1994;301 ( Pt 2)():415-20.
1994: P A Thomason; SR James; P J Casey; C Peter Downes
A G-protein beta gamma-subunit-responsive phosphoinositide 3-kinase activity in human platelet cytosol.
The Journal of biological chemistry 1994;269(24):16525-8.
1994: J A Bevilacqua; C Peter Downes; Pedro R Lowenstein
Visualization of agonist-stimulated inositol phospholipid turnover in individual neurons of the rat cerebral cortex and hippocampus.
Neuroscience 1994;60(4):945-58.
1994: SR James; R A Demel; C Peter Downes
Interfacial hydrolysis of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate by turkey erythrocyte phospholipase C.
The Biochemical journal 1994;298 ( Pt 2)():499-506.
1994: Ian H Batty; C Peter Downes
The inhibition of phosphoinositide synthesis and muscarinic-receptor-mediated phospholipase C activity by Li+ as secondary, selective, consequences of inositol depletion in 1321N1 cells.
The Biochemical journal 1994;297 ( Pt 3)():529-37.
1994: J A Bevilacqua; D Bain; C Peter Downes; Pedro R Lowenstein
Visualization of receptor coupled phosphoinositide turnover in single neurons and a glial cell line in culture.
Gene therapy 1994;1 Suppl 1():S69.
1993: C Peter Downes; Ian H Batty
Inositol lipid signalling exacts a transfer fee.
Current biology : CB 1993;3(11):794-6.
1993: S James; R Demel; C Peter Downes
The activity of a phospholipase C beta assayed using phospholipid monolayers.
Biochemical Society transactions 1993;21(4):392S.
1993: R M Baxter; J Bramham; P A Thomason; C Peter Downes; A N Carter
Characterisation of phosphatidylinositol 3-kinase in PC12 cell extracts and isolation of the enzyme from rat brain extracts.
Biochemical Society transactions 1993;21(4):359S.
1993: Cyrus Vaziri; C Peter Downes; S C Macfarlane
Direct labelling of hormone-sensitive phosphoinositides by a plasma-membrane-associated PtdIns synthase in turkey erythrocytes.
The Biochemical journal 1993;294 ( Pt 3)():793-9.
1993: Ian H Batty; A Michie; M Fennel; C Peter Downes
The characteristics, capacity and receptor regulation of inositol uptake in 1321N1 astrocytoma cells.
The Biochemical journal 1993;294 ( Pt 1)():49-55.
1993: David Gani; C Peter Downes; I Batty; J Bramham
Lithium and myo-inositol homeostasis.
Biochimica et biophysica acta 1993;1177(3):253-69.
1993: J A Bevilacqua; Ian H Batty; C Peter Downes; Pedro R Lowenstein
Localisation of agonist stimulated CMP-phosphatidate accumulation in single mammalian neurones.
Biochemical Society transactions 1993;21(2):118S.
1993: D J Sillence; C Peter Downes
Subcellular distribution of agonist-stimulated phosphatidylinositol synthesis in 1321 N1 astrocytoma cells.
The Biochemical journal 1993;290 ( Pt 2)():381-7.
1992: Cyrus Vaziri; C Peter Downes
Association of a receptor and G-protein-regulated phospholipase C with the cytoskeleton.
The Journal of biological chemistry 1992;267(32):22973-81.
1992: A N Carter; C Peter Downes
Phosphatidylinositol 3-kinase is activated by nerve growth factor and epidermal growth factor in PC12 cells.
The Journal of biological chemistry 1992;267(21):14563-7.
1992: Cyrus Vaziri; C Peter Downes
G-protein-mediated activation of turkey erythrocyte phospholipase C by beta-adrenergic and P2y-purinergic receptors.
The Biochemical journal 1992;284 ( Pt 3)():917-22.
1992: D J Sillence; C Peter Downes
Lithium treatment of affective disorders: effects of lithium on the inositol phospholipid and cyclic AMP signalling pathways.
Biochimica et biophysica acta 1992;1138(1):46-52.
1991: C Peter Downes; A N Carter
Phosphoinositide 3-kinase: a new effector in signal transduction?
Cellular signalling 1991;3(6):501-13.
1990: C Peter Downes; C H Macphee
myo-inositol metabolites as cellular signals.
European journal of biochemistry / FEBS 1990;193(1):1-18.
1990: C Peter Downes; A N Carter
Inositol lipids and phosphates.
Current opinion in cell biology 1990;2(2):185-91.