Peter Downes

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Padmanabhan Usha; Dollins D Eric; Fridy Peter C; York John D; Downes C Peter
Characterization of a selective inhibitor of inositol hexakisphosphate kinases: use in defining biological roles and metabolic relationships of inositol pyrophosphates.
Leslie N R; Batty I H; Maccario H; Davidson L; Downes C P
Understanding PTEN regulation: PIP2, polarity and protein stability.
Hale Benjamin G; Batty Ian H; Downes C Peter; Randall Richard E
Binding of influenza A virus NS1 protein to the inter-SH2 domain of p85 suggests a novel mechanism for phosphoinositide 3-kinase activation.

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All Publications

2009: Padmanabhan Usha; Dollins D Eric; Fridy Peter C; York John D; Downes C Peter
Characterization of a selective inhibitor of inositol hexakisphosphate kinases: use in defining biological roles and metabolic relationships of inositol pyrophosphates.
The Journal of biological chemistry 2009;284(16):10571-82.
2008: Leslie N R; Batty I H; Maccario H; Davidson L; Downes C P
Understanding PTEN regulation: PIP2, polarity and protein stability.
Oncogene 2008;27(41):5464-76.
2008: Hale Benjamin G; Batty Ian H; Downes C Peter; Randall Richard E
Binding of influenza A virus NS1 protein to the inter-SH2 domain of p85 suggests a novel mechanism for phosphoinositide 3-kinase activation.
The Journal of biological chemistry 2008;283(3):1372-80.
2007: Lackey J; Barnett J; Davidson L; Batty I H; Leslie N R; Downes C P
Loss of PTEN selectively desensitizes upstream IGF1 and insulin signaling.
Oncogene 2007;26(50):7132-42.
2007: Batty Ian H; van der Kaay Jeroen; Gray Alex; Telfer Joan F; Dixon Miles J; Downes C Peter
The control of phosphatidylinositol 3,4-bisphosphate concentrations by activation of the Src homology 2 domain containing inositol polyphosphate 5-phosphatase 2, SHIP2.
The Biochemical journal 2007;407(2):255-66.
2007: Maccario Helene; Perera Nevin M; Davidson Lindsay; Downes C Peter; Leslie Nick R
PTEN is destabilized by phosphorylation on Thr366.
The Biochemical journal 2007;405(3):439-44.
2007: Ross Sarah H; Lindsay Yvonne; Safrany Stephen T; Lorenzo Oscar; Villa Fabrizio; Toth Rachel; Clague Michael J; Downes C Peter; Leslie Nick R
Differential redox regulation within the PTP superfamily.
Cellular signalling 2007;19(7):1521-30.
2007: Downes C P; Leslie N R; Batty I H; van der Kaay J
Metabolic switching of PI3K-dependent lipid signals.
Biochemical Society transactions 2007;35(Pt 2):188-92.
2007: Leslie Nick R; Yang Xuesong; Downes C Peter; Weijer Cornelis J
PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration.
Current biology : CB 2007;17(2):115-25.
2007: Downes C Peter; Ross Sarah; Maccario Helene; Perera Nevin; Davidson Lindsay; Leslie Nick R
Stimulation of PI 3-kinase signaling via inhibition of the tumor suppressor phosphatase, PTEN.
Advances in enzyme regulation 2007;47():184-94.
2007: Downes C Peter; Perera Nevin; Ross Sarah; Leslie Nick R
Substrate specificity and acute regulation of the tumour suppressor phosphatase, PTEN.
Biochemical Society symposium 2007;(74):69-80.
2006: Lindsay Yvonne; McCoull David; Davidson Lindsay; Leslie Nick R; Fairservice Alison; Gray Alex; Lucocq John; Downes C Peter
Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression.
Journal of cell science 2006;119(Pt 24):5160-8.
2006: Ning Ke; Miller Lisa C; Laidlaw Hilary A; Burgess Laura A; Perera Nevin M; Downes C Peter; Leslie Nick R; Ashford Michael L J
A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic beta-cells.
The EMBO journal 2006;25(11):2377-87.
2005: Leslie N R; Yang X; Downes C P; Weijer C J
The regulation of cell migration by PTEN.
Biochemical Society transactions 2005;33(Pt 6):1507-8.
2005: Downes C P; Gray A; Fairservice A; Safrany S T; Batty I H; Fleming I
The regulation of membrane to cytosol partitioning of signalling proteins by phosphoinositides and their soluble headgroups.
Biochemical Society transactions 2005;33(Pt 6):1303-7.
2005: Downes C Peter; Gray Alex; Lucocq John M
Probing phosphoinositide functions in signaling and membrane trafficking.
Trends in cell biology 2005;15(5):259-68.
2004: Leslie N R; Lindsay Y; Ross S H; Downes C P
Redox regulation of phosphatase function.
Biochemical Society transactions 2004;32(Pt 6):1018-20.
2004: Fleming Ian N; Batty Ian H; Prescott Alan R; Gray Alex; Kular Gursant S; Stewart Hazel; Downes C Peter
Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1.
The Biochemical journal 2004;382(Pt 3):857-65.
2004: Leslie Nick R; Downes C Peter
PTEN function: how normal cells control it and tumour cells lose it.
The Biochemical journal 2004;382(Pt 1):1-11.
2004: Spruce Barbara A; Campbell Lorna A; McTavish Niall; Cooper Michelle A; Appleyard M Virginia L; O'Neill Mary; Howie Jacqueline; Samson Jayne; Watt Stephen; Murray Karen; McLean Doris; Leslie Nick R; Safrany Stephen T; Ferguson Michelle J; Peters John A; Prescott Alan R; Box Gary; Hayes Angela; Nutley Bernard; Raynaud Florence; Downes C Peter; Lambert Jeremy J; Thompson Alastair M; Eccles Suzanne
Small molecule antagonists of the sigma-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo.
Cancer research 2004;64(14):4875-86.
2004: Harrington Laura S; Findlay Greg M; Gray Alex; Tolkacheva Tatiana; Wigfield Simon; Rebholz Heike; Barnett Jill; Leslie Nick R; Cheng Susan; Shepherd Peter R; Gout Ivan; Downes C Peter; Lamb Richard F
The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins.
The Journal of cell biology 2004;166(2):213-23.
2004: Batty Ian H; Fleming Ian N; Downes C Peter
Muscarinic-receptor-mediated inhibition of insulin-like growth factor-1 receptor-stimulated phosphoinositide 3-kinase signalling in 1321N1 astrocytoma cells.
The Biochemical journal 2004;379(Pt 3):641-51.
2004: Downes C P; Walker S; McConnachie G; Lindsay Y; Batty I H; Leslie N R
Acute regulation of the tumour suppressor phosphatase, PTEN, by anionic lipids and reactive oxygen species.
Biochemical Society transactions 2004;32(Pt 2):338-42.
2004: Walker Steven M; Leslie Nick R; Perera Nevin M; Batty Ian H; Downes C Peter
The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif.
The Biochemical journal 2004;379(Pt 2):301-7.
2004: Watt Stephen A; Kimber Wendy A; Fleming Ian N; Leslie Nick R; Downes C Peter; Lucocq John M
Detection of novel intracellular agonist responsive pools of phosphatidylinositol 3,4-bisphosphate using the TAPP1 pleckstrin homology domain in immunoelectron microscopy.
The Biochemical journal 2004;377(Pt 3):653-63.
2004: Orchiston Elaine A; Bennett Deborah; Leslie Nick R; Clarke Rosemary G; Winward Lucinda; Downes C Peter; Safrany Stephen T
PTEN M-CBR3, a versatile and selective regulator of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5). Evidence for Ins(1,3,4,5,6)P5 as a proliferative signal.
The Journal of biological chemistry 2004;279(2):1116-22.
2003: Leslie Nick R; Bennett Deborah; Lindsay Yvonne E; Stewart Hazel; Gray Alex; Downes C Peter
Redox regulation of PI 3-kinase signalling via inactivation of PTEN.
The EMBO journal 2003;22(20):5501-10.
2003: Bentley Johanne; Itchayanan Dalina; Barnes Kay; McIntosh Elizabeth; Tang Xiuwen; Downes C Peter; Holman Geoffrey D; Whetton Anthony D; Owen-Lynch P Jane; Baldwin Stephen A
Interleukin-3-mediated cell survival signals include phosphatidylinositol 3-kinase-dependent translocation of the glucose transporter GLUT1 to the cell surface.
The Journal of biological chemistry 2003;278(41):39337-48.
2003: Tang Xiuwen; Wang Lijun; Proud Christopher G; Downes C Peter
Muscarinic receptor-mediated activation of p70 S6 kinase 1 (S6K1) in 1321N1 astrocytoma cells: permissive role of phosphoinositide 3-kinase.
The Biochemical journal 2003;374(Pt 1):137-43.
2003: McConnachie George; Pass Ian; Walker Steven M; Downes C Peter
Interfacial kinetic analysis of the tumour suppressor phosphatase, PTEN: evidence for activation by anionic phospholipids.
The Biochemical journal 2003;371(Pt 3):947-55.
2003: Downes C Peter; Gray Alexander; Watt Stephen A; Lucocq John M
Advances in procedures for the detection and localization of inositol phospholipid signals in cells, tissues, and enzyme assays.
Methods in enzymology 2003;366():64-84.
2002: Watt Stephen A; Kular Gursant; Fleming Ian N; Downes C Peter; Lucocq John M
Subcellular localization of phosphatidylinositol 4,5-bisphosphate using the pleckstrin homology domain of phospholipase C delta1.
The Biochemical journal 2002;363(Pt 3):657-66.
2002: Leslie Nick R; Downes C Peter
PTEN: The down side of PI 3-kinase signalling.
Cellular signalling 2002;14(4):285-95.
2002: Radimerski Thomas; Montagne Jacques; Rintelen Felix; Stocker Hugo; van der Kaay Jeroen; Downes C Peter; Hafen Ernst; Thomas George
dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1.
Nature cell biology 2002;4(3):251-5.
2002: Kimber Wendy A; Trinkle-Mulcahy Laura; Cheung Peter C F; Deak Maria; Marsden Louisa J; Kieloch Agnieszka; Watt Stephen; Javier Ronald T; Gray Alex; Downes C Peter; Lucocq John M; Alessi Dario R
Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo.
The Biochemical journal 2002;361(Pt 3):525-36.
2002: Tang Xiuwen; Batty Ian H; Downes C Peter
Muscarinic receptors mediate phospholipase C-dependent activation of protein kinase B via Ca2+, ErbB3, and phosphoinositide 3-kinase in 1321N1 astrocytoma cells.
The Journal of biological chemistry 2002;277(1):338-44.
2001: Walker S M; Downes C P; Leslie N R
TPIP: a novel phosphoinositide 3-phosphatase.
The Biochemical journal 2001;360(Pt 2):277-83.
2001: Downes C P; Bennett D; McConnachie G; Leslie N R; Pass I; MacPhee C; Patel L; Gray A
Antagonism of PI 3-kinase-dependent signalling pathways by the tumour suppressor protein, PTEN.
Biochemical Society transactions 2001;29(Pt 6):846-51.
2001: Hill E; Olusanya O; van der Kaay J; Downes C P; Andrews P D; Swedlow J R; Smythe E
Regulation of clathrin-coated vesicle formation.
Biochemical Society transactions 2001;29(Pt 4):375-7.
2001: Leslie N R; Bennett D; Gray A; Pass I; Hoang-Xuan K; Downes C P
Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions.
The Biochemical journal 2001;357(Pt 2):427-35.
2001: Patel L; Pass I; Coxon P; Downes C P; Smith S A; Macphee C H
Tumor suppressor and anti-inflammatory actions of PPARgamma agonists are mediated via upregulation of PTEN.
Current biology : CB 2001;11(10):764-8.
2001: Hajduch E; Balendran A; Batty I H; Litherland G J; Blair A S; Downes C P; Hundal H S
Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells.
Diabetologia 2001;44(2):173-83.
2001: Hill E; van Der Kaay J; Downes C P; Smythe E
The role of dynamin and its binding partners in coated pit invagination and scission.
The Journal of cell biology 2001;152(2):309-23.
2000: Parekh D B; Katso R M; Leslie N R; Downes C P; Procyk K J; Waterfield M D; Parker P J
Beta1-integrin and PTEN control the phosphorylation of protein kinase C.
The Biochemical journal 2000;352 Pt 2():425-33.
2000: Shinomura T; del Río E; Breen K C; Downes C P; McLaughlin M
Activation of phospholipase D by metabotropic glutamate receptor agonists in rat cerebrocortical synaptosomes.
British journal of pharmacology 2000;131(5):1011-8.
2000: Dowler S; Currie R A; Campbell D G; Deak M; Kular G; Downes C P; Alessi D R
Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities.
The Biochemical journal 2000;351(Pt 1):19-31.
2000: Fleming I N; Gray A; Downes C P
Regulation of the Rac1-specific exchange factor Tiam1 involves both phosphoinositide 3-kinase-dependent and -independent components.
The Biochemical journal 2000;351(Pt 1):173-82.
2000: Tang X; Downes C P; Whetton A D; Owen-Lynch P J
Role of phosphatidylinositol 3-kinase and specific protein kinase B isoforms in the suppression of apoptosis mediated by the Abelson protein-tyrosine kinase.
The Journal of biological chemistry 2000;275(17):13142-8.
2000: Leslie N R; Gray A; Pass I; Orchiston E A; Downes C P
Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinase.
The Biochemical journal 2000;346 Pt 3():827-33.
2000: Harvey J; McKay N G; Walker K S; Van der Kaay J; Downes C P; Ashford M L
Essential role of phosphoinositide 3-kinase in leptin-induced K(ATP) channel activation in the rat CRI-G1 insulinoma cell line.
The Journal of biological chemistry 2000;275(7):4660-9.
1999: Gray A; Van Der Kaay J; Downes C P
The pleckstrin homology domains of protein kinase B and GRP1 (general receptor for phosphoinositides-1) are sensitive and selective probes for the cellular detection of phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 3,4,5-trisphosphate in vivo.
The Biochemical journal 1999;344 Pt 3():929-36.
1999: Van der Kaay J; Beck M; Gray A; Downes C P
Distinct phosphatidylinositol 3-kinase lipid products accumulate upon oxidative and osmotic stress and lead to different cellular responses.
The Journal of biological chemistry 1999;274(50):35963-8.
1999: Ponnambalam S; Clough S; Downes C P; Lucocq J M; McLauchlan H J; Towler M C
Lipid kinases and trans-Golgi network membrane dynamics.
Biochemical Society transactions 1999;27(4):670-3.
1999: Dowler S; Currie R A; Downes C P; Alessi D R
DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides.
The Biochemical journal 1999;342 ( Pt 1)():7-12.
1999: Deak M; Casamayor A; Currie R A; Downes C P; Alessi D R
Characterisation of a plant 3-phosphoinositide-dependent protein kinase-1 homologue which contains a pleckstrin homology domain.
FEBS letters 1999;451(3):220-6.
1999: Hajduch E; Rencurel F; Balendran A; Batty I H; Downes C P; Hundal H S
Serotonin (5-Hydroxytryptamine), a novel regulator of glucose transport in rat skeletal muscle.
The Journal of biological chemistry 1999;274(19):13563-8.
1999: Balendran A; Casamayor A; Deak M; Paterson A; Gaffney P; Currie R; Downes C P; Alessi D R
PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.
Current biology : CB 1999;9(8):393-404.
1999: Fleming I N; Elliott C M; Buchanan F G; Downes C P; Exton J H
Ca2+/calmodulin-dependent protein kinase II regulates Tiam1 by reversible protein phosphorylation.
The Journal of biological chemistry 1999;274(18):12753-8.
1999: Currie R A; Walker K S; Gray A; Deak M; Casamayor A; Downes C P; Cohen P; Alessi D R; Lucocq J
Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1.
The Biochemical journal 1999;337 ( Pt 3)():575-83.
1998: Downes C P; Currie R A
Lipid signalling.
Current biology : CB 1998;8(24):R865-7.
1998: Alessi D R; Downes C P
The role of PI 3-kinase in insulin action.
Biochimica et biophysica acta 1998;1436(1-2):151-64.
1998: Myers M P; Pass I; Batty I H; Van der Kaay J; Stolarov J P; Hemmings B A; Wigler M H; Downes C P; Tonks N K
The lipid phosphatase activity of PTEN is critical for its tumor supressor function.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(23):13513-8.
1998: Ellis M V; James S R; Perisic O; Downes C P; Williams R L; Katan M
Catalytic domain of phosphoinositide-specific phospholipase C (PLC). Mutational analysis of residues within the active site and hydrophobic ridge of plcdelta1.
The Journal of biological chemistry 1998;273(19):11650-9.
1998: Banfic H; Downes C P; Rittenhouse S E
Biphasic activation of PKBalpha/Akt in platelets. Evidence for stimulation both by phosphatidylinositol 3,4-bisphosphate, produced via a novel pathway, and by phosphatidylinositol 3,4,5-trisphosphate.
The Journal of biological chemistry 1998;273(19):11630-7.
1998: del Río E; Shinomura T; van der Kaay J; Nicholls D G; Downes C P
Disruption by lithium of phosphoinositide signalling in cerebellar granule cells in primary culture.
Journal of neurochemistry 1998;70(4):1662-9.
1998: Batty I H; Currie R A; Downes C P
Evidence for a model of integrated inositol phospholipid pools implies an essential role for lipid transport in the maintenance of receptor-mediated phospholipase C activity in 1321N1 cells.
The Biochemical journal 1998;330 ( Pt 3)():1069-77.
1998: Banfic H; Tang X; Batty I H; Downes C P; Chen C; Rittenhouse S E
A novel integrin-activated pathway forms PKB/Akt-stimulatory phosphatidylinositol 3,4-bisphosphate via phosphatidylinositol 3-phosphate in platelets.
The Journal of biological chemistry 1998;273(1):13-6.
1998: van der Kaay J; Cullen P J; Downes C P
Phosphatidylinositol(3,4,5)trisphosphate (Ptdins(3,4,5)P3) mass measurement using a radioligand displacement assay.
Methods in molecular biology (Clifton, N.J.) 1998;105():109-25.
1997: Hickinson D M; Lucocq J M; Towler M C; Clough S; James J; James S R; Downes C P; Ponnambalam S
Association of a phosphatidylinositol-specific 3-kinase with a human trans-Golgi network resident protein.
Current biology : CB 1997;7(12):987-90.
1997: Batty I H; Hickinson D M; Downes C P
Cross-talk between phospholipase C and phosphoinositide 3-kinase signalling pathways.
Biochemical Society transactions 1997;25(4):1132-7.
1997: James S R; Downes C P
Structural and mechanistic features of phospholipases C: effectors of inositol phospholipid-mediated signal transduction.
Cellular signalling 1997;9(5):329-36.
1997: McDowell H E; Walker T; Hajduch E; Christie G; Batty I H; Downes C P; Hundal H S
Inositol phospholipid 3-kinase is activated by cellular stress but is not required for the stress-induced activation of glucose transport in L6 rat skeletal muscle cells.
European journal of biochemistry / FEBS 1997;247(1):306-13.
1997: Tang X; Downes C P
Purification and characterization of Gbetagamma-responsive phosphoinositide 3-kinases from pig platelet cytosol.
The Journal of biological chemistry 1997;272(22):14193-9.
1997: Cross D A; Watt P W; Shaw M; van der Kaay J; Downes C P; Holder J C; Cohen P
Insulin activates protein kinase B, inhibits glycogen synthase kinase-3 and activates glycogen synthase by rapamycin-insensitive pathways in skeletal muscle and adipose tissue.
FEBS letters 1997;406(1-2):211-5.
1997: Alessi D R; James S R; Downes C P; Holmes A B; Gaffney P R; Reese C B; Cohen P
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha.
Current biology : CB 1997;7(4):261-9.
1997: Currie R A; MacLeod B M; Downes C P
The lipid transfer activity of phosphatidylinositol transfer protein is sufficient to account for enhanced phospholipase C activity in turkey erythrocyte ghosts.
Current biology : CB 1997;7(3):184-90.
1997: van der Kaay J; Batty I H; Cross D A; Watt P W; Downes C P
A novel, rapid, and highly sensitive mass assay for phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) and its application to measure insulin-stimulated PtdIns(3,4,5)P3 production in rat skeletal muscle in vivo.
The Journal of biological chemistry 1997;272(9):5477-81.
1997: James S R; Paterson A; Harden T K; Demel R A; Downes C P
Dependence of the activity of phospholipase C beta on surface pressure and surface composition in phospholipid monolayers and its implications for their regulation.
Biochemistry 1997;36(4):848-55.
1996: Batty I H; Downes C P
Thrombin receptors modulate insulin-stimulated phosphatidylinositol 3,4,5-trisphosphate accumulation in 1321N1 astrocytoma cells.
The Biochemical journal 1996;317 ( Pt 2)():347-51.
1996: James S R; Downes C P; Gigg R; Grove S J; Holmes A B; Alessi D R
Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation.
The Biochemical journal 1996;315 ( Pt 3)():709-13.
1996: James S R; Smith S; Paterson A; Harden T K; Downes C P
Time-dependent inhibition of phospholipase C beta-catalysed phosphoinositide hydrolysis: a comparison of different assays.
The Biochemical journal 1996;314 ( Pt 3)():917-21.
1995: Bevilacqua J A; Downes C P; Lowenstein P R
Transiently selective activation of phosphoinositide turnover in layer V pyramidal neurons after specific mGluRs stimulation in rat somatosensory cortex during early postnatal development.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(12):7916-28.
1995: Baxter R M; Cohen P; Obermeier A; Ullrich A; Downes C P; Doza Y N
Phosphotyrosine residues in the nerve-growth-factor receptor (Trk-A). Their role in the activation of inositolphospholipid metabolism and protein kinase cascades in phaeochromocytoma (PC12) cells.
European journal of biochemistry / FEBS 1995;234(1):84-91.
1995: Batty I H; Downes C P
The mechanism of muscarinic receptor-stimulated phosphatidylinositol resynthesis in 1321N1 astrocytoma cells and its inhibition by Li+.
Journal of neurochemistry 1995;65(5):2279-89.
1995: Tsakiridis T; McDowell H E; Walker T; Downes C P; Hundal H S; Vranic M; Klip A
Multiple roles of phosphatidylinositol 3-kinase in regulation of glucose transport, amino acid transport, and glucose transporters in L6 skeletal muscle cells.
Endocrinology 1995;136(10):4315-22.
1995: James S R; Paterson A; Harden T K; Downes C P
Kinetic analysis of phospholipase C beta isoforms using phospholipid-detergent mixed micelles. Evidence for interfacial catalysis involving distinct micelle binding and catalytic steps.
The Journal of biological chemistry 1995;270(20):11872-81.
1994: James S R; Vaziri C; Walker T R; Milligan G; Downes C P
The turkey erythrocyte beta-adrenergic receptor couples to both adenylate cyclase and phospholipase C via distinct G-protein alpha subunits.
The Biochemical journal 1994;304 ( Pt 2)():359-64.
1994: Estevez F; Pulford D; Stark M J; Carter A N; Downes C P
Inositol trisphosphate metabolism in Saccharomyces cerevisiae: identification, purification and properties of inositol 1,4,5-trisphosphate 6-kinase.
The Biochemical journal 1994;302 ( Pt 3)():709-16.
1994: del Río E; Nicholls D G; Downes C P
Involvement of calcium influx in muscarinic cholinergic regulation of phospholipase C in cerebellar granule cells.
Journal of neurochemistry 1994;63(2):535-43.
1994: Carter A N; Huang R; Sorisky A; Downes C P; Rittenhouse S E
Phosphatidylinositol 3,4,5-trisphosphate is formed from phosphatidylinositol 4,5-bisphosphate in thrombin-stimulated platelets.
The Biochemical journal 1994;301 ( Pt 2)():415-20.
1994: Thomason P A; James S R; Casey P J; Downes C P
A G-protein beta gamma-subunit-responsive phosphoinositide 3-kinase activity in human platelet cytosol.
The Journal of biological chemistry 1994;269(24):16525-8.
1994: Bevilacqua J A; Downes C P; Lowenstein P R
Visualization of agonist-stimulated inositol phospholipid turnover in individual neurons of the rat cerebral cortex and hippocampus.
Neuroscience 1994;60(4):945-58.
1994: James S R; Demel R A; Downes C P
Interfacial hydrolysis of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate by turkey erythrocyte phospholipase C.
The Biochemical journal 1994;298 ( Pt 2)():499-506.
1994: Batty I H; Downes C P
The inhibition of phosphoinositide synthesis and muscarinic-receptor-mediated phospholipase C activity by Li+ as secondary, selective, consequences of inositol depletion in 1321N1 cells.
The Biochemical journal 1994;297 ( Pt 3)():529-37.
1994: Bevilacqua J A; Bain D; Downes C P; Lowenstein P R
Visualization of receptor coupled phosphoinositide turnover in single neurons and a glial cell line in culture.
Gene therapy 1994;1 Suppl 1():S69.
1993: Downes C P; Batty I H
Inositol lipid signalling exacts a transfer fee.
Current biology : CB 1993;3(11):794-6.
1993: James S; Demel R; Downes C P
The activity of a phospholipase C beta assayed using phospholipid monolayers.
Biochemical Society transactions 1993;21(4):392S.
1993: Baxter R M; Bramham J; Thomason P A; Downes C P; Carter A N
Characterisation of phosphatidylinositol 3-kinase in PC12 cell extracts and isolation of the enzyme from rat brain extracts.
Biochemical Society transactions 1993;21(4):359S.
1993: Vaziri C; Downes C P; Macfarlane S C
Direct labelling of hormone-sensitive phosphoinositides by a plasma-membrane-associated PtdIns synthase in turkey erythrocytes.
The Biochemical journal 1993;294 ( Pt 3)():793-9.
1993: Batty I H; Michie A; Fennel M; Downes C P
The characteristics, capacity and receptor regulation of inositol uptake in 1321N1 astrocytoma cells.
The Biochemical journal 1993;294 ( Pt 1)():49-55.
1993: Gani D; Downes C P; Batty I; Bramham J
Lithium and myo-inositol homeostasis.
Biochimica et biophysica acta 1993;1177(3):253-69.
1993: Bevilacqua J A; Batty I H; Downes C P; Lowenstein P R
Localisation of agonist stimulated CMP-phosphatidate accumulation in single mammalian neurones.
Biochemical Society transactions 1993;21(2):118S.
1993: Sillence D J; Downes C P
Subcellular distribution of agonist-stimulated phosphatidylinositol synthesis in 1321 N1 astrocytoma cells.
The Biochemical journal 1993;290 ( Pt 2)():381-7.
1992: Vaziri C; Downes C P
Association of a receptor and G-protein-regulated phospholipase C with the cytoskeleton.
The Journal of biological chemistry 1992;267(32):22973-81.
1992: Carter A N; Downes C P
Phosphatidylinositol 3-kinase is activated by nerve growth factor and epidermal growth factor in PC12 cells.
The Journal of biological chemistry 1992;267(21):14563-7.
1992: Vaziri C; Downes C P
G-protein-mediated activation of turkey erythrocyte phospholipase C by beta-adrenergic and P2y-purinergic receptors.
The Biochemical journal 1992;284 ( Pt 3)():917-22.
1992: Sillence D J; Downes C P
Lithium treatment of affective disorders: effects of lithium on the inositol phospholipid and cyclic AMP signalling pathways.
Biochimica et biophysica acta 1992;1138(1):46-52.
1991: Downes C P; Carter A N
Phosphoinositide 3-kinase: a new effector in signal transduction?
Cellular signalling 1991;3(6):501-13.
1990: Downes C P; Macphee C H
myo-inositol metabolites as cellular signals.
European journal of biochemistry / FEBS 1990;193(1):1-18.
1990: Downes C P; Carter A N
Inositol lipids and phosphates.
Current opinion in cell biology 1990;2(2):185-91.

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