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Gregory Downey

Research Profile

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Rachel L Zemans; Yael Aschner; Natalie Briones; Michael Kahn; Lester F Lau; Jazalle McClendon; Scott K Young; Gregory P Downey
Role of β-catenin-regulated CCN matricellular proteins in epithelial repair after inflammatory lung injury.
Qin Wang; Katherine A Siminovitch; Gregory P Downey; Christopher A McCulloch
Ras-guanine-nucleotide-releasing factors 1 and 2 interact with PLCγ at focal adhesions to enable IL-1-induced Ca(2+) signalling, ERK activation and MMP-3 expression.
Dhaarmini Rajshankar; Gregory P Downey; Christopher A McCulloch
IL-1β enhances cell adhesion to degraded fibronectin.

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2013: Rachel L Zemans; Yael Aschner; Natalie Briones; Michael Kahn; Lester F Lau; Jazalle McClendon; Scott K Young; Gregory P Downey
Role of β-catenin-regulated CCN matricellular proteins in epithelial repair after inflammatory lung injury.
American journal of physiology. Lung cellular and molecular physiology 2013;304(6):L415-27.
2013: Qin Wang; Katherine A Siminovitch; Gregory P Downey; Christopher A McCulloch
Ras-guanine-nucleotide-releasing factors 1 and 2 interact with PLCγ at focal adhesions to enable IL-1-induced Ca(2+) signalling, ERK activation and MMP-3 expression.
The Biochemical journal 2013;449(3):771-82.
2012: Dhaarmini Rajshankar; Gregory P Downey; Christopher A McCulloch
IL-1β enhances cell adhesion to degraded fibronectin.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(11):4429-44.
2012: Ronald S Flannagan; Gregory P Downey; Kassidy K Huynh; Valentin Jaumouillé; Jonathan D Plumb; Miguel A Valvano; Sergio Grinstein
Burkholderia cenocepacia disrupts host cell actin cytoskeleton by inactivating Rac and Cdc42.
Cellular microbiology 2012;14(2):239-54.
2011: Eric P Schmidt; Cory Yamashita; Rachel L Zemans; Warren L Lee; Gregory P Downey
On, around, and through: neutrophil-endothelial interactions in innate immunity.
Physiology (Bethesda, Md.) 2011;26(5):334-47.
2011: Cory M Yamashita; Scott K Young; Guoying Yu; Rachel L Zemans; Natalie Briones; Megan N Campbell; Lior Dolgonos; Jack Gauldie; Naftali Kaminski; Christopher A G McCulloch; Derek Radisky; David W H Riches; Jennifer Robertson; Tomoko Suzuki; Gregory P Downey
Matrix metalloproteinase 3 is a mediator of pulmonary fibrosis.
The American journal of pathology 2011;179(4):1733-45.
2011: Qin Wang; Gregory P Downey; Christopher A McCulloch
Focal adhesions and Ras are functionally and spatially integrated to mediate IL-1 activation of ERK.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(10):3448-64.
2011: Rachel L Zemans; Natalie Briones; Megan Campbell; Sean P Colgan; Stijn P De Langhe; Peter M Henson; Michael Kahn; Robert J Mason; Jazalle McClendon; Susan D Reynolds; Tomoko Suzuki; Ivana V Yang; Scott K Young; Gregory P Downey
Neutrophil transmigration triggers repair of the lung epithelium via beta-catenin signaling.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(38):15990-5.
2010: Qin Wang; Dhaarmini Rajshankar; Carol A Laschinger; Ilana Talior-Volodarsky; Yongqiang Wang; Gregory P Downey; Christopher A McCulloch
Importance of protein-tyrosine phosphatase-alpha catalytic domains for interactions with SHP-2 and interleukin-1-induced matrix metalloproteinase-3 expression.
The Journal of biological chemistry 2010;285(29):22308-17.
2010: Kassidy K Huynh; Jonathan D Plumb; Gregory P Downey; Miguel A Valvano; Sergio Grinstein
Inactivation of macrophage Rab7 by Burkholderia cenocepacia.
Journal of innate immunity 2010;2(6):522-33.
2010: Mikiko Shimizu; Pankaj Saxena; Igor E Konstantinov; Vera Cherepanov; Michael M H Cheung; Peter Wearden; Hua Zhangdong; Michael Schmidt; Gregory P Downey; Andrew N Redington
Remote ischemic preconditioning decreases adhesion and selectively modifies functional responses of human neutrophils.
The Journal of surgical research 2010;158(1):155-61.
2009: Tomoko Suzuki; Cory Yamashita; Rachel L Zemans; Natalie Briones; Annemie Van Linden; Gregory P Downey
Leukocyte elastase induces lung epithelial apoptosis via a PAR-1-, NF-kappaB-, and p53-dependent pathway.
American journal of respiratory cell and molecular biology 2009;41(6):742-55.
2009: Qin Wang; Dhaarmini Rajshankar; Donald R Branch; Katherine A Siminovitch; Maria Teresa Herrera Abreu; Gregory P Downey; Christopher A McCulloch
Protein-tyrosine phosphatase-alpha and Src functionally link focal adhesions to the endoplasmic reticulum to mediate interleukin-1-induced Ca2+ signaling.
The Journal of biological chemistry 2009;284(31):20763-72.
2009: Theo J Moraes; Bijan Rafii; Frank Niessen; Tomoko Suzuki; Raiza Martin; Eric Vachon; Wolfgang Vogel; Wolfram Ruf; Hugh O'Brodovich; Gregory P Downey
Protease-activated receptor (Par)1 alters bioelectric properties of distal lung epithelia without compromising barrier function.
Experimental lung research 2009;35(2):136-54.
2008: Stephen C Juvet; David Hwang; Thomas K Waddell; Gregory P Downey
Rare lung disease II: pulmonary alveolar proteinosis.
Canadian respiratory journal : journal of the Canadian Thoracic Society 2008;15(4):203-10.
2008: Maria Teresa Herrera Abreu; Patricia Castellanos Penton; Vivian Kwok; Eric Vachon; David Shalloway; Luis Vidali; Wilson Lee; Christopher A McCulloch; Gregory P Downey
Tyrosine phosphatase PTPalpha regulates focal adhesion remodeling through Rac1 activation.
American journal of physiology. Cell physiology 2008;294(4):C931-44.
2008: Theo J Moraes; Raiza Martin; Jonathan D Plumb; Eric Vachon; Cheryl M Cameron; Ali Danesh; David J Kelvin; Wolfram Ruf; Gregory P Downey
Role of PAR2 in murine pulmonary pseudomonal infection.
American journal of physiology. Lung cellular and molecular physiology 2008;294(2):L368-77.
2008: Tomoko Suzuki; Chung-Wai Chow; Gregory P Downey
Role of innate immune cells and their products in lung immunopathology.
The international journal of biochemistry & cell biology 2008;40(6-7):1348-61.
2007: Eric Vachon; Raiza Martin; Vivian Kwok; Vera Cherepanov; Chung-Wai Chow; Claire Doerschuk; Jonathan Plumb; Sergio Grinstein; Gregory P Downey
CD44-mediated phagocytosis induces inside-out activation of complement receptor-3 in murine macrophages.
Blood 2007;110(13):4492-502.
2007: Stephen C Juvet; Francis X McCormack; David J Kwiatkowski; Gregory P Downey
Molecular pathogenesis of lymphangioleiomyomatosis: lessons learned from orphans.
American journal of respiratory cell and molecular biology 2007;36(4):398-408.
2007: Stacey M Pollock-BarZiv; Marsha M Cohen; Gregory P Downey; Simon R Johnson; Eugene Sullivan; Francis X McCormack
Air travel in women with lymphangioleiomyomatosis.
Thorax 2007;62(2):176-80.
2006: Qin Wang; Maria Teresa Herrera-Abreu; Katherine A Siminovitch; Gregory P Downey; Christopher A McCulloch
Phosphorylation of SHP-2 regulates interactions between the endoplasmic reticulum and focal adhesions to restrict interleukin-1-induced Ca2+ signaling.
The Journal of biological chemistry 2006;281(41):31093-105.
2006: Stephen C Juvet; David Hwang; Gregory P Downey
Rare lung diseases I--Lymphangioleiomyomatosis.
Canadian respiratory journal : journal of the Canadian Thoracic Society 2006;13(7):375-80.
2006: Christopher A McCulloch; Gregory P Downey; Hani El-Gabalawy
Signalling platforms that modulate the inflammatory response: new targets for drug development.
Nature reviews. Drug discovery 2006;5(10):864-76.
2006: Heather L Greenwood; Peter A Singer; Gregory P Downey; Douglas K Martin; Halla Thorsteinsdóttir; Abdallah S Daar
Regenerative medicine and the developing world.
PLoS medicine 2006;3(9):e381.
2006: Nimrod Maimon; Narinder Paul; Gregory P Downey
Progressive dyspnea associated with a crazy-paving appearance on a chest computed tomography scan.
Canadian respiratory journal : journal of the Canadian Thoracic Society 2006;13(5):269-71.
2006: Eric Vachon; Raiza Martin; Jonathan Plumb; Vivian Kwok; R William Vandivier; Glogauer Michael; Andras Kapus; Xiaomin Wang; Chung-Wai Chow; Sergio Grinstein; Gregory P Downey
CD44 is a phagocytic receptor.
Blood 2006;107(10):4149-58.
2006: Maria Teresa Herrera-Abreu; Qin Wang; Eric Vachon; Tomoko Suzuki; Chung-Wai Chow; Yingchun Wang; Ouyang Hong; Jesús Villar; Christopher A McCulloch; Gregory P Downey
Tyrosine phosphatase SHP-2 regulates IL-1 signaling in fibroblasts through focal adhesions.
Journal of cellular physiology 2006;207(1):132-43.
2006: Cynthia R A Aoki; Hattie Liu; Gregory P Downey; Jane Mitchell; Richard L Horner
Cyclic nucleotides modulate genioglossus and hypoglossal responses to excitatory inputs in rats.
American journal of respiratory and critical care medicine 2006;173(5):555-65.
2006: Theo J Moraes; Jonathan Plumb; Raiza Martin; Eric Vachon; Vera Cherepanov; Adeline Koh; Carola Loeve; Jenny Jongstra-Bilen; Joanna H Zurawska; Julianne Kus; Lori L Burrows; Sergio Grinstein; Gregory P Downey
Abnormalities in the pulmonary innate immune system in cystic fibrosis.
American journal of respiratory cell and molecular biology 2006;34(3):364-74.
2006: Léa Fialkow; Luciano Fochesatto Filho; Mary C Bozzetti; Adriana R Milani; Edison M Rodrigues Filho; Roberta M Ladniuk; Paula Pierozan; Rafaela M de Moura; João C Prolla; Eric Vachon; Gregory P Downey
Neutrophil apoptosis: a marker of disease severity in sepsis and sepsis-induced acute respiratory distress syndrome.
Critical care (London, England) 2006;10(6):R155.
2006: Theo J Moraes; Gregory P Downey
Death of the septic monocyte: is more better?
Critical care (London, England) 2006;10(3):146.
2006: Theo J Moraes; Joanna H Zurawska; Gregory P Downey
Neutrophil granule contents in the pathogenesis of lung injury.
Current opinion in hematology 2006;13(1):21-7.
2005: Yingchun Wang; Eric Vachon; Jinyi Zhang; Vera Cherepanov; Joshua Kruger; Jun Li; Kan Saito; Patrick Shannon; Nunzio Bottini; Huong Huynh; Heyu Ni; Hong Yang; Colin McKerlie; Sue Quaggin; Zhizhuang Joe Zhao; Philip A Marsden; Tomas Mustelin; Katherine A Siminovitch; Gregory P Downey
Tyrosine phosphatase MEG2 modulates murine development and platelet and lymphocyte activation through secretory vesicle function.
The Journal of experimental medicine 2005;202(11):1587-97.
2005: Tomoko Suzuki; Theo J Moraes; Eric Vachon; Hedy H Ginzberg; Tsun-Tsao Huang; Michael A Matthay; Morley D Hollenberg; John Marshall; Christopher A McCulloch; Maria Teresa Herrera Abreu; Chung-Wai Chow; Gregory P Downey
Proteinase-activated receptor-1 mediates elastase-induced apoptosis of human lung epithelial cells.
American journal of respiratory cell and molecular biology 2005;33(3):231-47.
2005: Stacey M Pollock-BarZiv; Marsha M Cohen; Heather Maclean; Gregory P Downey
Patients' perceptions versus medical testing of function in women with lymphangioleiomyomatosis (LAM).
Respiratory medicine 2005;99(7):901-9.
2005: Qin Wang; Gregory P Downey; Elena Bajenova; Maite Abreu; Andras Kapus; Christopher A McCulloch
Mitochondrial function is a critical determinant of IL-1-induced ERK activation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(7):837-9.
2005: Qin Wang; Gregory P Downey; Maria Teresa Herrera-Abreu; Andras Kapus; Christopher A McCulloch
SHP-2 modulates interleukin-1-induced Ca2+ flux and ERK activation via phosphorylation of phospholipase Cgamma1.
The Journal of biological chemistry 2005;280(9):8397-406.
2005: Barry B Rubin; Gregory P Downey; Adeline Koh; Norbert Degousee; Farideh Ghomashchi; Laxman Nallan; Eva Stefanski; Denis W Harkin; Chunxiang Sun; Brian P Smart; Thomas F Lindsay; Vera Cherepanov; Eric Vachon; David Kelvin; Martin Sadilek; Glenn E Brown; Michael B Yaffe; Jonathan Plumb; Sergio Grinstein; Glogauer Michael; Michael H Gelb
Cytosolic phospholipase A2-alpha is necessary for platelet-activating factor biosynthesis, efficient neutrophil-mediated bacterial killing, and the innate immune response to pulmonary infection: cPLA2-alpha does not regulate neutrophil NADPH oxidase activity.
The Journal of biological chemistry 2005;280(9):7519-29.
2004: Chun Xiang Sun; Gregory P Downey; Fei Zhu; Adeline L Y Koh; Herman Thang; Glogauer Michael
Rac1 is the small GTPase responsible for regulating the neutrophil chemotaxis compass.
Blood 2004;104(12):3758-65.
2004: David R Koehler; Gregory P Downey; Neil B Sweezey; A Keith Tanswell; Jim Hu
Lung inflammation as a therapeutic target in cystic fibrosis.
American journal of respiratory cell and molecular biology 2004;31(4):377-81.
2004: Igor E Konstantinov; Sara Arab; Rajesh K Kharbanda; Jia Li; Michael M H Cheung; Vera Cherepanov; Gregory P Downey; Peter P Liu; Eva Cukerman; John G Coles; Andrew N Redington
The remote ischemic preconditioning stimulus modifies inflammatory gene expression in humans.
Physiological genomics 2004;19(1):143-50.
2004: Huong Huynh; Nunzio Bottini; Scott Williams; Vera Cherepanov; Lucia Musumeci; Kan Saito; Shane Bruckner; Eric Vachon; Xiaodong Wang; Joshua Kruger; Chung-Wai Chow; Surya De; Edward Monosov; Peter A Greer; William Trimble; Gregory P Downey; Tomas Mustelin
Control of vesicle fusion by a tyrosine phosphatase.
Nature cell biology 2004;6(9):831-9.
2004: Hedy H Ginzberg; Patrick T Shannon; Tomoko Suzuki; Ouyang Hong; Eric Vachon; Theo J Moraes; Maria Teresa Herrera Abreu; Vera Cherepanov; Xiaomin Wang; Chung-Wai Chow; Gregory P Downey
Leukocyte elastase induces epithelial apoptosis: role of mitochondial permeability changes and Akt.
American journal of physiology. Gastrointestinal and liver physiology 2004;287(1):G286-98.
2004: Chung-Wai Chow; Gregory P Downey; Sergio Grinstein
Measurements of phagocytosis and phagosomal maturation.
Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.] 2004;Chapter 15():Unit 15.7.
2004: Lisa Cicutto; Carolina Braidy; Sharon Moloney; Michael A Hutcheon; D Linn Holness; Gregory P Downey
Factors affecting attainment of paid employment after lung transplantation.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2004;23(4):481-6.
2004: Marita Gilljam; Yuri Moltyaner; Gregory P Downey; Roslyn Devlin; Peter Roy Durie; André M Cantin; Julian Zielenski; D Elizabeth Tullis
Airway inflammation and infection in congenital bilateral absence of the vas deferens.
American journal of respiratory and critical care medicine 2004;169(2):174-9.
2004: Lisa Cicutto; Gregory P Downey
Biological markers in diagnosing, monitoring, and treating asthma: a focus on noninvasive measurements.
AACN clinical issues 2004;15(1):97-111.
2003: Yuri Moltyaner; W H Geerts; DW Chamberlain; Paul G Heyworth; Deborah Noack; Julie Rae; J J Doyle; Gregory P Downey
Underlying chronic granulomatous disease in a patient with bronchocentric granulomatosis.
Thorax 2003;58(12):1096-8.
2003: Theo J Moraes; Gregory P Downey
Neutrophil cell signaling in infection: role of phosphatidylinositide 3-kinase.
Microbes and infection / Institut Pasteur 2003;5(14):1293-8.
2003: Qin Wang; Gregory P Downey; Christine Choi; Andras Kapus; Christopher A McCulloch
IL-1 induced release of Ca2+ from internal stores is dependent on cell-matrix interactions and regulates ERK activation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(13):1898-900.
2003: Chung-Wai Chow; Maria Teresa Herrera-Abreu; Tomoko Suzuki; Gregory P Downey
Oxidative stress and acute lung injury.
American journal of respiratory cell and molecular biology 2003;29(4):427-31.
2003: Mairi MacGillivray; Maria Teresa Herrera-Abreu; Chung-Wai Chow; Christina Shek; Qin Wang; Eric Vachon; Gen-Sheng Feng; Katherine A Siminovitch; Christopher A McCulloch; Gregory P Downey
The protein tyrosine phosphatase SHP-2 regulates interleukin-1-induced ERK activation in fibroblasts.
The Journal of biological chemistry 2003;278(29):27190-8.
2003: Ziqiang Ding; Thomas B Issekutz; Gregory P Downey; Thomas K Waddell
L-selectin stimulation enhances functional expression of surface CXCR4 in lymphocytes: implications for cellular activation during adhesion and migration.
Blood 2003;101(11):4245-52.
2003: Xiaoping Luo; Rosetta Belcastro; Judy Cabacungan; Vicky Hannam; Anna Negus; Yanxia Wen; Jonathan Plumb; Jim Hu; Brent Steer; David R Koehler; Gregory P Downey; A Keith Tanswell
Transfection of lung cells in vitro and in vivo: effect of antioxidants and intraliposomal bFGF.
American journal of physiology. Lung cellular and molecular physiology 2003;284(5):L817-25.
2003: Theo J Moraes; Chung-Wai Chow; Gregory P Downey
Proteases and lung injury.
Critical care medicine 2003;31(4 Suppl):S189-94.
2002: Haibo Zhang; Gregory P Downey; Peter M Suter; Arthur Slutsky; V Marco Ranieri
Conventional mechanical ventilation is associated with bronchoalveolar lavage-induced activation of polymorphonuclear leukocytes: a possible mechanism to explain the systemic consequences of ventilator-induced lung injury in patients with ARDS.
Anesthesiology 2002;97(6):1426-33.
2002: Stacey M Pollock-BarZiv; Marsha M Cohen; Heather Maclean; Gregory P Downey
Canadian respirologists' experience with lymphangioleiomyomatosis.
Canadian respiratory journal : journal of the Canadian Thoracic Society 2002;9(6):413-6.
2002: Warren L Lee; Gregory P Downey
ICU Cornerstone: changing our view of blood transfusions.
Critical care (London, England) 2002;6(4):291-2.
2002: Joshua M Kruger; Takayasu Fukushima; Vera Cherepanov; Niels Borregaard; Carola Loeve; Christina Shek; Kalpana Sharma; A Keith Tanswell; Chung-Wai Chow; Gregory P Downey
Protein-tyrosine phosphatase MEG2 is expressed by human neutrophils. Localization to the phagosome and activation by polyphosphoinositides.
The Journal of biological chemistry 2002;277(4):2620-8.
2001: T Tsakiridis; Evangelia Tsiani; Poli Lekas; A Bergman; Vera Cherepanov; Catharine I Whiteside; Gregory P Downey
Insulin, insulin-like growth factor-I, and platelet-derived growth factor activate extracellular signal-regulated kinase by distinct pathways in muscle cells.
Biochemical and biophysical research communications 2001;288(1):205-11.
2001: Hedy H Ginzberg; V Cherapanov; Q Dong; André M Cantin; Christopher A McCulloch; Patrick T Shannon; Gregory P Downey
Neutrophil-mediated epithelial injury during transmigration: role of elastase.
American journal of physiology. Gastrointestinal and liver physiology 2001;281(3):G705-17.
2001: Umadevi S Sajjan; G Thanassoulis; V Cherapanov; A Lu; C Sjolin; Brent Steer; Y J Wu; Ori D Rotstein; Geraldine Kent; Colin McKerlie; Janet F Forstner; Gregory P Downey
Enhanced susceptibility to pulmonary infection with Burkholderia cepacia in Cftr(-/-) mice.
Infection and immunity 2001;69(8):5138-50.
2001: Warren L Lee; Gregory P Downey
Neutrophil activation and acute lung injury.
Current opinion in critical care 2001;7(1):1-7.
2000: J Kruger; JR Butler; V Cherapanov; Q Dong; Hedy H Ginzberg; A Govindarajan; Sergio Grinstein; Katherine A Siminovitch; Gregory P Downey
Deficiency of Src homology 2-containing phosphatase 1 results in abnormalities in murine neutrophil function: studies in motheaten mice.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(10):5847-59.
2000: Pamela D Arora; Morris F Manolson; Gregory P Downey; Jaro Sodek; Christopher A McCulloch
A novel model system for characterization of phagosomal maturation, acidification, and intracellular collagen degradation in fibroblasts.
The Journal of biological chemistry 2000;275(45):35432-41.
2000: David R Dancey; DW Chamberlain; Mel Krajden; Joel Palefsky; PW Alberti; Gregory P Downey
Successful treatment of juvenile laryngeal papillomatosis-related multicystic lung disease with cidofovir: case report and review of the literature.
Chest 2000;118(4):1210-4.
2000: Lisa Cicutto; K R Chapman; D Chamberlain; Gregory P Downey
Difficult asthma: consider all of the possibilities.
Canadian respiratory journal : journal of the Canadian Thoracic Society 2000;7(5):415-8.
2000: Jenny Jongstra-Bilen; VL Misener; Chunjie Wang; Hedy H Ginzberg; A Auerbach; Alexandra L Joyner; Gregory P Downey; Jan Jongstra
LSP1 modulates leukocyte populations in resting and inflamed peritoneum.
Blood 2000;96(5):1827-35.
2000: Hedy H Ginzberg; Patrick T Shannon; Gregory P Downey
Neutrophil products and alterations in epithelial junctional proteins: prevention of artifactual degradation.
Journal of immunological methods 2000;239(1-2):45-52.
1999: T Tsakiridis; P Tong; B Matthews; Evangelia Tsiani; Philip J Bilan; Amira Klip; Gregory P Downey
Role of the actin cytoskeleton in insulin action.
Microscopy research and technique 1999;47(2):79-92.
1999: Gregory P Downey; Roberto J Botelho; JR Butler; Yuri Moltyaner; P Chien; Alan D Schreiber; Sergio Grinstein
Phagosomal maturation, acidification, and inhibition of bacterial growth in nonphagocytic cells transfected with FcgammaRIIA receptors.
The Journal of biological chemistry 1999;274(40):28436-44.
1999: Scott I Simon; V Cherapanov; I Nadra; T K Waddell; S M Seo; Q Wang; Claire Doerschuk; Gregory P Downey
Signaling functions of L-selectin in neutrophils: alterations in the cytoskeleton and colocalization with CD18.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(5):2891-901.
1999: Gregory P Downey; Q Dong; J Kruger; S Dedhar; V Cherapanov
Regulation of neutrophil activation in acute lung injury.
Chest 1999;116(1 Suppl):46S-54S.
1999: Q Dong; Katherine A Siminovitch; Léa Fialkow; T Fukushima; Gregory P Downey
Negative regulation of myeloid cell proliferation and function by the SH2 domain-containing tyrosine phosphatase-1.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(6):3220-30.
1999: R Zent; Menachem Ailenberg; Gregory P Downey; Mel Silverman
ROS stimulate reorganization of mesangial cell-collagen gels by tyrosine kinase signaling.
The American journal of physiology 1999;276(2 Pt 2):F278-87.
1998: T Tsakiridis; A Bergman; Romel Somwar; C Taha; K Aktories; TF Cruz; Amira Klip; Gregory P Downey
Actin filaments facilitate insulin activation of the src and collagen homologous/mitogen-activated protein kinase pathway leading to DNA synthesis and c-fos expression.
The Journal of biological chemistry 1998;273(43):28322-31.
1998: Glogauer Michael; Pam Arora; D Chou; P A Janmey; Gregory P Downey; Christopher A McCulloch
The role of actin-binding protein 280 in integrin-dependent mechanoprotection.
The Journal of biological chemistry 1998;273(3):1689-98.
1998: Gregory P Downey; JR Butler; H Tapper; Léa Fialkow; Alan Saltiel; Barry B Rubin; Sergio Grinstein
Importance of MEK in neutrophil microbicidal responsiveness.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(1):434-43.
1997: Yoshinori Marunaka; Y Shintani; Gregory P Downey; Naomi Niisato
Activation of Na+-permeant cation channel by stretch and cyclic AMP-dependent phosphorylation in renal epithelial A6 cells.
The Journal of general physiology 1997;110(3):327-36.
1997: AK Sue-A-Quan; Léa Fialkow; chris vlahos; J A Schelm; Sergio Grinstein; J Butler; Gregory P Downey
Inhibition of neutrophil oxidative burst and granule secretion by wortmannin: potential role of MAP kinase and renaturable kinases.
Journal of cellular physiology 1997;172(1):94-108.
1997: Léa Fialkow; C K Chan; Gregory P Downey
Inhibition of CD45 during neutrophil activation.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(11):5409-17.
1997: D M Hyde; Gregory P Downey; F Tablin; S Rosengren; P C Giclas; Peter M Henson; G Scott Worthen
Age-dependent neutrophil and blood flow responsiveness in acute pulmonary inflammation in rabbits.
The American journal of physiology 1997;272(3 Pt 1):L471-8.
1997: John H Brumell; C K Chan; J Butler; N Borregaard; K A Siminovitch; Sergio Grinstein; Gregory P Downey
Regulation of Src homology 2-containing tyrosine phosphatase 1 during activation of human neutrophils. Role of protein kinase C.
The Journal of biological chemistry 1997;272(2):875-82.
1996: Gregory P Downey; J R Butler; John H Brumell; Niels Borregaard; L Kjeldsen; A K Sue-A-Quan; Sergio Grinstein
Chemotactic peptide-induced activation of MEK-2, the predominant isoform in human neutrophils. Inhibition by wortmannin.
The Journal of biological chemistry 1996;271(35):21005-1011.
1996: N Demaurex; Gregory P Downey; T K Waddell; Sergio Grinstein
Intracellular pH regulation during spreading of human neutrophils.
The Journal of cell biology 1996;133(6):1391-402.
1996: T Fukushima; T K Waddell; Sergio Grinstein; G G Goss; John Orlowski; Gregory P Downey
Na+/H+ exchange activity during phagocytosis in human neutrophils: role of Fcgamma receptors and tyrosine kinases.
The Journal of cell biology 1996;132(6):1037-52.
1995: Gregory P Downey; T Fukushima; Léa Fialkow; T K Waddell
Intracellular signaling in neutrophil priming and activation.
Seminars in cell biology 1995;6(6):345-56.
1995: Gregory P Downey; T K Waddell; T Fukushima; A Sue-A-Quan
Current techniques in cell and molecular biology.
Journal of critical care 1995;10(3):136-49.
1995: T K Waddell; Léa Fialkow; Charles K N Chan; T K Kishimoto; Gregory P Downey
Signaling functions of L-selectin. Enhancement of tyrosine phosphorylation and activation of MAP kinase.
The Journal of biological chemistry 1995;270(25):15403-11.
1995: Gregory P Downey; Léa Fialkow; T Fukushima
Initial interaction of leukocytes within the microvasculature: deformability, adhesion, and transmigration.
New horizons (Baltimore, Md.) 1995;3(2):219-28.
1995: Gregory P Downey; Sergio Grinstein; A Sue-A-Quan; B Czaban; Charles K N Chan
Volume regulation in leukocytes: requirement for an intact cytoskeleton.
Journal of cellular physiology 1995;163(1):96-104.
1995: R Zent; Menachem Ailenberg; T K Waddell; Gregory P Downey; Mel Silverman
Puromycin aminonucleoside inhibits mesangial cell-induced contraction of collagen gels by stimulating production of reactive oxygen species.
Kidney international 1995;47(3):811-7.
1995: Gregory P Downey; T Fukushima; Léa Fialkow
Signaling mechanisms in human neutrophils.
Current opinion in hematology 1995;2(1):76-88.
1994: Léa Fialkow; Charles K N Chan; D Rotin; Sergio Grinstein; Gregory P Downey
Activation of the mitogen-activated protein kinase signaling pathway in neutrophils. Role of oxidants.
The Journal of biological chemistry 1994;269(49):31234-42.
1994: D Rotin; Dafna Bar-Sagi; H O'Brodovich; J Merilainen; V P Lehto; C M Canessa; B C Rossier; Gregory P Downey
An SH3 binding region in the epithelial Na+ channel (alpha rENaC) mediates its localization at the apical membrane.
The EMBO journal 1994;13(19):4440-50.
1994: Sergio Grinstein; J R Butler; Wendy Furuya; G L'Allemain; Gregory P Downey
Chemotactic peptides induce phosphorylation and activation of MEK-1 in human neutrophils.
The Journal of biological chemistry 1994;269(30):19313-20.
1994: T K Waddell; Léa Fialkow; Charles K N Chan; T K Kishimoto; Gregory P Downey
Potentiation of the oxidative burst of human neutrophils. A signaling role for L-selectin.
The Journal of biological chemistry 1994;269(28):18485-91.
1994: D E Doherty; Gregory P Downey; B Schwab; E Elson; G Scott Worthen
Lipolysaccharide-induced monocyte retention in the lung. Role of monocyte stiffness, actin assembly, and CD18-dependent adherence.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(1):241-55.
1994: G G Goss; MJ Woodside; S Wakabayashi; J Pouyssegur; T Waddell; Gregory P Downey; Sergio Grinstein
ATP dependence of NHE-1, the ubiquitous isoform of the Na+/H+ antiporter. Analysis of phosphorylation and subcellular localization.
The Journal of biological chemistry 1994;269(12):8741-8.
1994: Gregory P Downey; Charles K N Chan; Léa Fialkow
NADPH oxidase-derived reactive oxygen intermediates regulate tyrosine phosphorylation in human neutrophils.
Chest 1994;105(3 Suppl):85S.
1994: Gregory P Downey
Mechanisms of leukocyte motility and chemotaxis.
Current opinion in immunology 1994;6(1):113-24.
1994: G Scott Worthen; Peter M Henson; S Rosengren; Gregory P Downey; D M Hyde
Neutrophils increase volume during migration in vivo and in vitro.
American journal of respiratory cell and molecular biology 1994;10(1):1-7.
1993: Sergio Grinstein; MJ Woodside; T K Waddell; Gregory P Downey; John Orlowski; J Pouyssegur; D C Wong; J Kevin Foskett
Focal localization of the NHE-1 isoform of the Na+/H+ antiport: assessment of effects on intracellular pH.
The EMBO journal 1993;12(13):5209-18.
1993: Léa Fialkow; Charles K N Chan; Sergio Grinstein; Gregory P Downey
Regulation of tyrosine phosphorylation in neutrophils by the NADPH oxidase. Role of reactive oxygen intermediates.
The Journal of biological chemistry 1993;268(23):17131-7.
1993: Gregory P Downey; A Takai; R Zamel; Sergio Grinstein; Charles K N Chan
Okadaic acid-induced actin assembly in neutrophils: role of protein phosphatases.
Journal of cellular physiology 1993;155(3):505-19.
1992: Sergio Grinstein; Wendy Furuya; Gregory P Downey
Activation of permeabilized neutrophils: role of anions.
The American journal of physiology 1992;263(1 Pt 1):C78-85.
1992: S C Erzurum; Gregory P Downey; D E Doherty; B Schwab; E L Elson; G Scott Worthen
Mechanisms of lipopolysaccharide-induced neutrophil retention. Relative contributions of adhesive and cellular mechanical properties.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(1):154-62.
1992: Y Mitsumoto; Gregory P Downey; Amira Klip
Stimulation of glucose transport in L6 muscle cells by long-term intermittent stretch-relaxation.
FEBS letters 1992;301(1):94-8.
1992: Gregory P Downey; Charles K N Chan; P Lea; A Takai; Sergio Grinstein
Phorbol ester-induced actin assembly in neutrophils: role of protein kinase C.
The Journal of cell biology 1992;116(3):695-706.
1991: V Misener; Gregory P Downey; Jan Jongstra
The immunoglobulin light chain related protein lambda 5 is expressed on the surface of mouse pre-B cell lines and can function as a signal transducing molecule.
International immunology 1991;3(11):1129-36.
1991: Gregory P Downey; E L Elson; B Schwab; S C Erzurum; Scott K Young; G Scott Worthen
Biophysical properties and microfilament assembly in neutrophils: modulation by cyclic AMP.
The Journal of cell biology 1991;114(6):1179-90.
1991: I Melamed; Gregory P Downey; K Aktories; Chaim M Roifman
Microfilament assembly is required for antigen-receptor-mediated activation of human B lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(4):1139-46.
1991: I Melamed; Gregory P Downey; Chaim M Roifman
Tyrosine phosphorylation is essential for microfilament assembly in B lymphocytes.
Biochemical and biophysical research communications 1991;176(3):1424-9.
1991: P G Hellewell; Peter M Henson; Gregory P Downey; G Scott Worthen
Control of local blood flow in pulmonary inflammation: role for neutrophils, PAF, and thromboxane.
Journal of applied physiology (Bethesda, Md. : 1985) 1991;70(3):1184-93.
1990: Gregory P Downey; D E Doherty; B Schwab; E L Elson; Peter M Henson; G Scott Worthen
Retention of leukocytes in capillaries: role of cell size and deformability.
Journal of applied physiology (Bethesda, Md. : 1985) 1990;69(5):1767-78.
1990: S Trudel; Gregory P Downey; Sergio Grinstein; M R Pâquet
Activation of permeabilized HL60 cells by vanadate. Evidence for divergent signalling pathways.
The Biochemical journal 1990;269(1):127-31.
1990: Gregory P Downey; Charles K N Chan; S Trudel; Sergio Grinstein
Actin assembly in electropermeabilized neutrophils: role of intracellular calcium.
The Journal of cell biology 1990;110(6):1975-82.
1990: Claire Doerschuk; Gregory P Downey; D E Doherty; D English; R P Gie; M Ohgami; G Scott Worthen; P M Henson; James C Hogg
Leukocyte and platelet margination within microvasculature of rabbit lungs.
Journal of applied physiology (Bethesda, Md. : 1985) 1990;68(5):1956-61.
1989: G Scott Worthen; B Schwab; E L Elson; Gregory P Downey
Mechanics of stimulated neutrophils: cell stiffening induces retention in capillaries.
Science (New York, N.Y.) 1989;245(4914):183-6.
1988: Gregory P Downey; G Scott Worthen
Neutrophil retention in model capillaries: deformability, geometry, and hydrodynamic forces.
Journal of applied physiology (Bethesda, Md. : 1985) 1988;65(4):1861-71.
1988: D E Doherty; Gregory P Downey; G Scott Worthen; C Haslett; Peter M Henson
Monocyte retention and migration in pulmonary inflammation. Requirement for neutrophils.
Laboratory investigation; a journal of technical methods and pathology 1988;59(2):200-13.
1988: Gregory P Downey; R S Gumbay; D E Doherty; J F LaBrecque; J E Henson; Peter M Henson; G Scott Worthen
Enhancement of pulmonary inflammation by PGE2: evidence for a vasodilator effect.
Journal of applied physiology (Bethesda, Md. : 1985) 1988;64(2):728-41.