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James Downey

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
122
Cohen, Michael
36
Yang, Xi-Ming
27
Liu, Guang
18
Critz, Stuart
13
Krieg, Thomas
11
Baines, CP
9
Cui, Lin
9
Heusch, Gerd
9
Philipp, Sebastian
9
Qin, Qining
7
Oldenburg, Olaf
6
Yellon, Derek
6
Miki, T
6
Nakano, Atsushi
5
Krenz, Maike

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Publications

TOP 3
Downey James M; Cohen Michael V
Why do we still not have cardioprotective drugs?
Cohen Michel V; Downey James M
Modulation of receptor sensitivity: possible therapeutic target?
Cohen Michael V; Downey James M
Adenosine at reperfusion: a conundrum ready to be resolved.

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All Publications

2009: Downey James M; Cohen Michael V
Why do we still not have cardioprotective drugs?
Circulation journal : official journal of the Japanese Circulation Society 2009;73(7):1171-7.
2009: Cohen Michel V; Downey James M
Modulation of receptor sensitivity: possible therapeutic target?
British journal of pharmacology 2009;156(6):899-900.
2009: Cohen Michael V; Downey James M
Adenosine at reperfusion: a conundrum ready to be resolved.
Journal of the American College of Cardiology 2009;53(8):718-9.
2008: Kuno Atsushi; Solenkova Nataliya V; Solodushko Victoriya; Dost Turhan; Liu Yanping; Yang Xi-Ming; Cohen Michael V; Downey James M
Infarct limitation by a protein kinase G activator at reperfusion in rabbit hearts is dependent on sensitizing the heart to A2b agonists by protein kinase C.
American journal of physiology. Heart and circulatory physiology 2008;295(3):H1288-H1295.
2008: Cohen Michael V; Yang Xi-Ming; Downey James M
Acidosis, oxygen, and interference with mitochondrial permeability transition pore formation in the early minutes of reperfusion are critical to postconditioning's success.
Basic research in cardiology 2008;103(5):464-71.
2008: Cohen Michael V; Downey James M
Oestrogen plays a permissive role in cardioprotection.
Cardiovascular research 2008;79(3):353-4.
2008: Dost Turhan; Cohen Michael V; Downey James M
Redox signaling triggers protection during the reperfusion rather than the ischemic phase of preconditioning.
Basic research in cardiology 2008;103(4):378-84.
2008: Cohen Michael V; Downey James M
Adenosine: trigger and mediator of cardioprotection.
Basic research in cardiology 2008;103(3):203-15.
2008: Downey James M; Krieg Thomas; Cohen Michael V
Mapping preconditioning's signaling pathways: an engineering approach.
Annals of the New York Academy of Sciences 2008;1123():187-96.
2008: Costa Alexandre D T; Pierre Sandrine V; Cohen Michael V; Downey James M; Garlid Keith D
cGMP signalling in pre- and post-conditioning: the role of mitochondria.
Cardiovascular research 2008;77(2):344-52.
2008: Liu Yanping; Yang Xi-Ming; Iliodromitis Efstathios K; Kremastinos Dimitrios T; Dost Turhan; Cohen Michael V; Downey James M
Redox signaling at reperfusion is required for protection from ischemic preconditioning but not from a direct PKC activator.
Basic research in cardiology 2008;103(1):54-9.
2007: Downey James M; Davis Amanda M; Cohen Michael V
Signaling pathways in ischemic preconditioning.
Heart failure reviews 2007;12(3-4):181-8.
2007: Kuno Atsushi; Critz Stuart D; Cui Lin; Solodushko Victoriya; Yang Xi-Ming; Krahn Thomas; Albrecht Barbara; Philipp Sebastian; Cohen Michael V; Downey James M
Protein kinase C protects preconditioned rabbit hearts by increasing sensitivity of adenosine A2b-dependent signaling during early reperfusion.
Journal of molecular and cellular cardiology 2007;43(3):262-71.
2007: Cohen Michael V; Yang Xi-Ming; Downey James M
The pH hypothesis of postconditioning: staccato reperfusion reintroduces oxygen and perpetuates myocardial acidosis.
Circulation 2007;115(14):1895-903.
2007: Cohen Michael V; Philipp Sebastian; Krieg Thomas; Cui Lin; Kuno Atsushi; Solodushko Viktoriya; Downey James M
Preconditioning-mimetics bradykinin and DADLE activate PI3-kinase through divergent pathways.
Journal of molecular and cellular cardiology 2007;42(4):842-51.
2007: Tissier Renaud; Hamanaka Kazutoshi; Kuno Atsushi; Parker James C; Cohen Michael V; Downey James M
Total liquid ventilation provides ultra-fast cardioprotective cooling.
Journal of the American College of Cardiology 2007;49(5):601-5.
2007: Kuno Atsushi; Critz Stuart D; Cohen Michael V; Downey James M
Nicorandil opens mitochondrial K(ATP) channels not only directly but also through a NO-PKG-dependent pathway.
Basic research in cardiology 2007;102(1):73-9.
2006: Yang Xi-Ming; Philipp Sebastian; Downey James M; Cohen Michael V
Atrial natriuretic peptide administered just prior to reperfusion limits infarction in rabbit hearts.
Basic research in cardiology 2006;101(4):311-8.
2006: Philipp Sebastian; Yang Xi-Ming; Cui Lin; Davis Amanda M; Downey James M; Cohen Michael V
Postconditioning protects rabbit hearts through a protein kinase C-adenosine A2b receptor cascade.
Cardiovascular research 2006;70(2):308-14.
2006: Cohen Michael V; Yang Xi-Ming; Downey James M
Nitric oxide is a preconditioning mimetic and cardioprotectant and is the basis of many available infarct-sparing strategies.
Cardiovascular research 2006;70(2):231-9.
2006: Downey James M; Cohen Michael V
Reducing infarct size in the setting of acute myocardial infarction.
Progress in cardiovascular diseases 2006;48(5):363-71.
2006: Philipp Sebastian; Critz Stuart D; Cui Lin; Solodushko Viktoriya; Cohen Michael V; Downey James M
Localizing extracellular signal-regulated kinase (ERK) in pharmacological preconditioning's trigger pathway.
Basic research in cardiology 2006;101(2):159-67.
2006: Solenkova Nataliya V; Solodushko Viktoriya; Cohen Michael V; Downey James M
Endogenous adenosine protects preconditioned heart during early minutes of reperfusion by activating Akt.
American journal of physiology. Heart and circulatory physiology 2006;290(1):H441-9.
2005: Downey James M; Cohen Michael V
Unraveling the mysteries of classical preconditioning.
Journal of molecular and cellular cardiology 2005;39(6):845-8.
2005: Costa Alexandre D T; Garlid Keith D; West Ian C; Lincoln Thomas M; Downey James M; Cohen Michael V; Critz Stuart D
Protein kinase G transmits the cardioprotective signal from cytosol to mitochondria.
Circulation research 2005;97(4):329-36.
2005: Critz Stuart D; Cohen Michael V; Downey James M
Mechanisms of acetylcholine- and bradykinin-induced preconditioning.
Vascular pharmacology 2005;42(5-6):201-9.
2005: Krieg Thomas; Philipp Sebastian; Cui Lin; Dostmann Wolfgang R; Downey James M; Cohen Michael V
Peptide blockers of PKG inhibit ROS generation by acetylcholine and bradykinin in cardiomyocytes but fail to block protection in the whole heart.
American journal of physiology. Heart and circulatory physiology 2005;288(4):H1976-81.
2005: Yang Xi-Ming; Philipp Sebastian; Downey James M; Cohen Michael V
Postconditioning's protection is not dependent on circulating blood factors or cells but involves adenosine receptors and requires PI3-kinase and guanylyl cyclase activation.
Basic research in cardiology 2005;100(1):57-63.
2004: Krieg Thomas; Qin Qining; Philipp Sebastian; Alexeyev Mikhail F; Cohen Michael V; Downey James M
Acetylcholine and bradykinin trigger preconditioning in the heart through a pathway that includes Akt and NOS.
American journal of physiology. Heart and circulatory physiology 2004;287(6):H2606-11.
2004: Yang Xi-Ming; Proctor J Bradley; Cui Lin; Krieg Thomas; Downey James M; Cohen Michael V
Multiple, brief coronary occlusions during early reperfusion protect rabbit hearts by targeting cell signaling pathways.
Journal of the American College of Cardiology 2004;44(5):1103-10.
2004: Qin Qining; Yang Xi-Ming; Cui Lin; Critz Stuart D; Cohen Michael V; Browner Natasha C; Lincoln Thomas M; Downey James M
Exogenous NO triggers preconditioning via a cGMP- and mitoKATP-dependent mechanism.
American journal of physiology. Heart and circulatory physiology 2004;287(2):H712-8.
2004: Krieg T; Yang X-M; Downey J M; Schaffer S W; Cohen M V
Augmented taurine release is not the mechanism of ischemic preconditioning's cardioprotection.
Amino acids 2004;26(3):263-6.
2004: Krieg Thomas; Cui Lin; Qin Qining; Cohen Michael V; Downey James M
Mitochondrial ROS generation following acetylcholine-induced EGF receptor transactivation requires metalloproteinase cleavage of proHB-EGF.
Journal of molecular and cellular cardiology 2004;36(3):435-43.
2004: Yang Xi-Ming; Krieg Thomas; Cui Lin; Downey James M; Cohen Michael V
NECA and bradykinin at reperfusion reduce infarction in rabbit hearts by signaling through PI3K, ERK, and NO.
Journal of molecular and cellular cardiology 2004;36(3):411-21.
2004: Oldenburg Olaf; Qin Qining; Krieg Thomas; Yang Xi-Ming; Philipp Sebastian; Critz Stuart D; Cohen Michael V; Downey James M
Bradykinin induces mitochondrial ROS generation via NO, cGMP, PKG, and mitoKATP channel opening and leads to cardioprotection.
American journal of physiology. Heart and circulatory physiology 2004;286(1):H468-76.
2003: Zhang Shi Jun; Yang Xi-Ming; Liu Guang S; Cohen Michael V; Pemberton Karen; Downey James M
CGX-1051, a peptide from Conus snail venom, attenuates infarction in rabbit hearts when administered at reperfusion.
Journal of cardiovascular pharmacology 2003;42(6):764-71.
2003: Xu Zhelong; Downey James M; Cohen Michael V
Timing and duration of administration are crucial for antiinfarct effect of AMP 579 infused at reperfusion in rabbit heart.
Heart disease (Hagerstown, Md.) 2003;5(6):368-71.
2003: Oldenburg Olaf; Yang Xi-Ming; Krieg Thomas; Garlid Keith D; Cohen Michael V; Grover Gary J; Downey James M
P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts.
Journal of molecular and cellular cardiology 2003;35(9):1035-42.
2003: Krieg Thomas; Cohen Michael V; Downey James M
Mitochondria and their role in preconditioning's trigger phase.
Basic research in cardiology 2003;98(4):228-34.
2003: Oldenburg Olaf; Critz Stuart D; Cohen Michael V; Downey James M
Acetylcholine-induced production of reactive oxygen species in adult rabbit ventricular myocytes is dependent on phosphatidylinositol 3- and Src-kinase activation and mitochondrial K(ATP) channel opening.
Journal of molecular and cellular cardiology 2003;35(6):653-60.
2003: Oldenburg Olaf; Cohen Michael V; Downey James M
Mitochondrial K(ATP) channels in preconditioning.
Journal of molecular and cellular cardiology 2003;35(6):569-75.
2003: Krieg Thomas; Landsberger Martin; Alexeyev Mikhail F; Felix Stephan B; Cohen Michael V; Downey James M
Activation of Akt is essential for acetylcholine to trigger generation of oxygen free radicals.
Cardiovascular research 2003;58(1):196-202.
2003: Qin Qining; Downey James M; Cohen Michael V
Acetylcholine but not adenosine triggers preconditioning through PI3-kinase and a tyrosine kinase.
American journal of physiology. Heart and circulatory physiology 2003;284(2):H727-34.
2002: Krieg Thomas; Qin Qining; McIntosh Elizabeth C; Cohen Michael V; Downey James M
ACh and adenosine activate PI3-kinase in rabbit hearts through transactivation of receptor tyrosine kinases.
American journal of physiology. Heart and circulatory physiology 2002;283(6):H2322-30.
2002: Xu Zhelong; Jiao Zhe; Cohen Michael V; Downey James M
Protection from AMP 579 can be added to that from either cariporide or ischemic preconditioning in ischemic rabbit heart.
Journal of cardiovascular pharmacology 2002;40(4):510-8.
2002: Krenz Maike; Yang Xi-Ming; Qin Qining; Downey James M; Cohen Michael V
Dose-response relationships of the protective and antiprotective effects of acute ethanol exposure in isolated rabbit hearts.
Heart disease (Hagerstown, Md.) 2002;4(5):276-81.
2002: Krenz Maike; Oldenburg Olaf; Wimpee Holly; Cohen Michael V; Garlid Keith D; Critz Stuart D; Downey James M; Benoit Joseph N
Opening of ATP-sensitive potassium channels causes generation of free radicals in vascular smooth muscle cells.
Basic research in cardiology 2002;97(5):365-73.
2002: Yue Yuankun; Qin Qining; Cohen Michael V; Downey James M; Critz Stuart D
The relative order of mK(ATP) channels, free radicals and p38 MAPK in preconditioning's protective pathway in rat heart.
Cardiovascular research 2002;55(3):681-9.
2002: Oldenburg Olaf; Qin Qining; Sharma Ana R; Cohen Michael V; Downey James M; Benoit Joseph N
Acetylcholine leads to free radical production dependent on K(ATP) channels, G(i) proteins, phosphatidylinositol 3-kinase and tyrosine kinase.
Cardiovascular research 2002;55(3):544-52.
2002: Oldenburg Olaf; Cohen Michael V; Yellon Derek M; Downey James M
Mitochondrial K(ATP) channels: role in cardioprotection.
Cardiovascular research 2002;55(3):429-37.
2002: Nakano Atsushi; Heusch Gerd; Cohen Michael V; Downey James M
Preconditioning one myocardial region does not neccessarily precondition the whole rabbit heart.
Basic research in cardiology 2002;97(1):35-9.
2001: Xu Z; Cohen M V; Downey J M; Vanden Hoek T L; Yao Z
Attenuation of oxidant stress during reoxygenation by AMP 579 in cardiomyocytes.
American journal of physiology. Heart and circulatory physiology 2001;281(6):H2585-9.
2001: Krenz M; Baines C P; Heusch G; Downey J M; Cohen M V
Acute alcohol-induced protection against infarction in rabbit hearts: differences from and similarities to ischemic preconditioning.
Journal of molecular and cellular cardiology 2001;33(11):2015-22.
2001: Xu Z; Downey J M; Cohen M V
Amp 579 reduces contracture and limits infarction in rabbit heart by activating adenosine A2 receptors.
Journal of cardiovascular pharmacology 2001;38(3):474-81.
2001: Cohen M V; Yang X M; Liu G S; Heusch G; Downey J M
Acetylcholine, bradykinin, opioids, and phenylephrine, but not adenosine, trigger preconditioning by generating free radicals and opening mitochondrial K(ATP) channels.
Circulation research 2001;89(3):273-8.
2001: Yue Y; Krenz M; Cohen M V; Downey J M; Critz S D
Menadione mimics the infarct-limiting effect of preconditioning in isolated rat hearts.
American journal of physiology. Heart and circulatory physiology 2001;281(2):H590-5.
2001: Krenz M; Baines C P; Yang X M; Heusch G; Cohen M V; Downey J M
Acute ethanol exposure fails to elicit preconditioning-like protection in in situ rabbit hearts because of its continued presence during ischemia.
Journal of the American College of Cardiology 2001;37(2):601-7.
2000: Nakano A; Cohen M V; Critz S; Downey J M
SB 203580, an inhibitor of p38 MAPK, abolishes infarct-limiting effect of ischemic preconditioning in isolated rabbit hearts.
Basic research in cardiology 2000;95(6):466-71.
2000: Xu Z; Yang X M; Cohen M V; Neumann T; Heusch G; Downey J M
Limitation of infarct size in rabbit hearts by the novel adenosine receptor agonist AMP 579 administered at reperfusion.
Journal of molecular and cellular cardiology 2000;32(12):2339-47.
2000: Heusch G; Liu G S; Rose J; Cohen M V; Downey J M
No confirmation for a causal role of volume-regulated chloride channels in ischemic preconditioning in rabbits.
Journal of molecular and cellular cardiology 2000;32(12):2279-85.
2000: Pain T; Yang X M; Critz S D; Yue Y; Nakano A; Liu G S; Heusch G; Cohen M V; Downey J M
Opening of mitochondrial K(ATP) channels triggers the preconditioned state by generating free radicals.
Circulation research 2000;87(6):460-6.
2000: Downey J M; Cohen M V
Do mitochondrial K(ATP) channels serve as triggers rather than end-effectors of ischemic preconditioning's protection?
Basic research in cardiology 2000;95(4):272-4.
2000: Cohen M V; Yang X M; Neumann T; Heusch G; Downey J M
Favorable remodeling enhances recovery of regional myocardial function in the weeks after infarction in ischemically preconditioned hearts.
Circulation 2000;102(5):579-83.
2000: Nakano A; Liu G S; Heusch G; Downey J M; Cohen M V
Exogenous nitric oxide can trigger a preconditioned state through a free radical mechanism, but endogenous nitric oxide is not a trigger of classical ischemic preconditioning.
Journal of molecular and cellular cardiology 2000;32(7):1159-67.
2000: Nakano A; Cohen M V; Downey J M
Ischemic preconditioning: from basic mechanisms to clinical applications.
Pharmacology & therapeutics 2000;86(3):263-75.
2000: Nakano A; Baines C P; Kim S O; Pelech S L; Downey J M; Cohen M V; Critz S D
Ischemic preconditioning activates MAPKAPK2 in the isolated rabbit heart: evidence for involvement of p38 MAPK.
Circulation research 2000;86(2):144-51.
2000: Cohen M V; Baines C P; Downey J M
Ischemic preconditioning: from adenosine receptor to KATP channel.
Annual review of physiology 2000;62():79-109.
1999: Birincioglu M; Yang X M; Critz S D; Cohen M V; Downey J M
S-T segment voltage during sequential coronary occlusions is an unreliable marker of preconditioning.
The American journal of physiology 1999;277(6 Pt 2):H2435-41.
1999: Cohen M V; Yang X M; Downey J M
Smaller infarct after preconditioning does not predict extent of early functional improvement of reperfused heart.
The American journal of physiology 1999;277(5 Pt 2):H1754-61.
1999: Liu G S; Cohen M V; Mochly-Rosen D; Downey J M
Protein kinase C-epsilon is responsible for the protection of preconditioning in rabbit cardiomyocytes.
Journal of molecular and cellular cardiology 1999;31(10):1937-48.
1999: Baines C P; Wang L; Cohen M V; Downey J M
Myocardial protection by insulin is dependent on phospatidylinositol 3-kinase but not protein kinase C or KATP channels in the isolated rabbit heart.
Basic research in cardiology 1999;94(3):188-98.
1999: Miki T; Cohen M V; Downey J M
Failure of N-2-mercaptopropionyl glycine to reduce myocardial infarction after 3 days of reperfusion in rabbits.
Basic research in cardiology 1999;94(3):180-7.
1999: Baines C P; Cohen M V; Downey J M
Signal transduction in ischemic preconditioning: the role of kinases and mitochondrial K(ATP) channels.
Journal of cardiovascular electrophysiology 1999;10(5):741-54.
1999: Miki T; Swafford A N; Cohen M V; Downey J M
Second window of protection against infarction in conscious rabbits: real or artifactual.
Journal of molecular and cellular cardiology 1999;31(4):809-16.
1999: Baines C P; Liu G S; Birincioglu M; Critz S D; Cohen M V; Downey J M
Ischemic preconditioning depends on interaction between mitochondrial KATP channels and actin cytoskeleton.
The American journal of physiology 1999;276(4 Pt 2):H1361-8.
1999: Kim S O; Baines C P; Critz S D; Pelech S L; Katz S; Downey J M; Cohen M V
Ischemia induced activation of heat shock protein 27 kinases and casein kinase 2 in the preconditioned rabbit heart.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1999;77(6):559-67.
1998: Miki T; Liu G S; Cohen M V; Downey J M
Mild hypothermia reduces infarct size in the beating rabbit heart: a practical intervention for acute myocardial infarction?
Basic research in cardiology 1998;93(5):372-83.
1998: Hashimi M W; Thornton J D; Downey J M; Cohen M V
Loss of myocardial protection from ischemic preconditioning following chronic exposure to R(-)-N6-(2-phenylisopropyl)adenosine is related to defect at the adenosine A1 receptor.
Molecular and cellular biochemistry 1998;186(1-2):19-25.
1998: Miki T; Cohen M V; Downey J M
Opioid receptor contributes to ischemic preconditioning through protein kinase C activation in rabbits.
Molecular and cellular biochemistry 1998;186(1-2):3-12.
1998: Weinbrenner C; Baines C P; Liu G S; Armstrong S C; Ganote C E; Walsh A H; Honkanen R E; Cohen M V; Downey J M
Fostriecin, an inhibitor of protein phosphatase 2A, limits myocardial infarct size even when administered after onset of ischemia.
Circulation 1998;98(9):899-905.
1998: Weinbrenner C; Liu G S; Downey J M; Cohen M V
Cyclosporine A limits myocardial infarct size even when administered after onset of ischemia.
Cardiovascular research 1998;38(3):678-84.
1998: Baines C P; Wang L; Cohen M V; Downey J M
Protein tyrosine kinase is downstream of protein kinase C for ischemic preconditioning's anti-infarct effect in the rabbit heart.
Journal of molecular and cellular cardiology 1998;30(2):383-92.
1997: Cohen M V; Yang X M; Downey J M
Attenuation of S-T segment elevation during repetitive coronary occlusions truly reflects the protection of ischemic preconditioning and is not an epiphenomenon.
Basic research in cardiology 1997;92(6):426-34.
1997: Armstrong S C; Kao R; Gao W; Shivell L C; Downey J M; Honkanen R E; Ganote C E
Comparison of in vitro preconditioning responses of isolated pig and rabbit cardiomyocytes: effects of a protein phosphatase inhibitor, fostriecin.
Journal of molecular and cellular cardiology 1997;29(11):3009-24.
1997: Sato H; Miki T; Vallabhapurapu R P; Wang P; Liu G S; Cohen M V; Downey J M
The mechanism of protection from 5 (N-ethyl-N-isopropyl)amiloride differs from that of ischemic preconditioning in rabbit heart.
Basic research in cardiology 1997;92(5):339-50.
1997: Weinbrenner C; Liu G S; Cohen M V; Downey J M
Phosphorylation of tyrosine 182 of p38 mitogen-activated protein kinase correlates with the protection of preconditioning in the rabbit heart.
Journal of molecular and cellular cardiology 1997;29(9):2383-91.
1997: Cohen M V; Thornton J D; Thornton C S; Sato H; Miki T; Downey J M
Intravenous co-infusion of adenosine and norepinephrine preconditions the heart without adverse hemodynamic effects.
The Journal of thoracic and cardiovascular surgery 1997;114(2):236-42.
1997: Critz S D; Liu G S; Chujo M; Downey J M
Pinacidil but not nicorandil opens ATP-sensitive K+ channels and protects against simulated ischemia in rabbit myocytes.
Journal of molecular and cellular cardiology 1997;29(4):1123-30.
1997: Yang X M; Sato H; Downey J M; Cohen M V
Protection of ischemic preconditioning is dependent upon a critical timing sequence of protein kinase C activation.
Journal of molecular and cellular cardiology 1997;29(3):991-9.
1997: Cope D K; Impastato W K; Cohen M V; Downey J M
Volatile anesthetics protect the ischemic rabbit myocardium from infarction.
Anesthesiology 1997;86(3):699-709.
1997: Baines C P; Goto M; Downey J M
Oxygen radicals released during ischemic preconditioning contribute to cardioprotection in the rabbit myocardium.
Journal of molecular and cellular cardiology 1997;29(1):207-16.
1997: Downey J M; Cohen M V
Arguments in favor of protein kinase C playing an important role in ischemic preconditioning.
Basic research in cardiology 1997;92 Suppl 2():37-9.
1997: Downey J M; Cohen M V
Signal transduction in ischemic preconditioning.
Advances in experimental medicine and biology 1997;430():39-55.
1996: Wang P; Downey J M; Cohen M V
Mast cell degranulation does not contribute to ischemic preconditioning in isolated rabbit hearts.
Basic research in cardiology 1996;91(6):458-67.
1996: Cohen M V; Liu Y; Liu G S; Wang P; Weinbrenner C; Cordis G A; Das D K; Downey J M
Phospholipase D plays a role in ischemic preconditioning in rabbit heart.
Circulation 1996;94(7):1713-8.
1996: Weinbrenner C; Wang P; Downey J M
Loss of glycogen during preconditioning is not a prerequisite for protection of the rabbit heart.
Basic research in cardiology 1996;91(5):374-81.
1996: Goto M; Cohen M V; Downey J M
The role of protein kinase C in ischemic preconditioning.
Annals of the New York Academy of Sciences 1996;793():177-90.
1996: Yang X M; Baxter G F; Heads R J; Yellon D M; Downey J M; Cohen M V
Infarct limitation of the second window of protection in a conscious rabbit model.
Cardiovascular research 1996;31(5):777-83.
1996: Liu G S; Jacobson K A; Downey J M
An irreversible A1-selective adenosine agonist preconditions rabbit heart.
The Canadian journal of cardiology 1996;12(5):517-21.
1996: Wang P; Gallagher K P; Downey J M; Cohen M V
Pretreatment with endothelin-1 mimics ischemic preconditioning against infarction in isolated rabbit heart.
Journal of molecular and cellular cardiology 1996;28(3):579-88.
1996: Goto M; Cohen M V; van Wylen D G; Downey J M
Attenuated purine production during subsequent ischemia in preconditioned rabbit myocardium is unrelated to the mechanism of protection.
Journal of molecular and cellular cardiology 1996;28(3):447-54.
1996: Ardell J L; Yang X M; Barron B A; Downey J M; Cohen M V
Endogenous myocardial norepinephrine is not essential for ischemic preconditioning in rabbit heart.
The American journal of physiology 1996;270(3 Pt 2):H1078-84.
1996: Downey J M; Cohen M V
Preconditioning: markers vs. epiphenomena.
Basic research in cardiology 1996;91(1):35-7.
1996: Cohen M V; Downey J M
Myocardial preconditioning promises to be a novel approach to the treatment of ischemic heart disease.
Annual review of medicine 1996;47():21-9.
1995: Ytrehus K; Walsh R S; Richards S C; Downey J M
Hydrogen peroxide as a protective agent during reperfusion. A study in the isolated perfused rabbit heart subjected to regional ischemia.
Cardiovascular research 1995;30(6):1033-7.
1995: Cohen M V; Snell K S; Tsuchida A; Van Wylen D G; Downey J M
Effects of anesthesia and K+ ATP channel blockade on interstitial adenosine accumulation in ischemic rabbit myocardium.
Basic research in cardiology 1995;90(5):410-7.
1995: Goto M; Tsuchida A; Liu Y; Cohen M V; Downey J M
Transient inhibition of glucose uptake mimics ischemic preconditioning by salvaging ischemic myocardium in the rabbit heart.
Journal of molecular and cellular cardiology 1995;27(9):1883-94.
1995: Goto M; Liu Y; Yang X M; Ardell J L; Cohen M V; Downey J M
Role of bradykinin in protection of ischemic preconditioning in rabbit hearts.
Circulation research 1995;77(3):611-21.
1995: Armstrong S C; Liu G S; Downey J M; Ganote C E
Potassium channels and preconditioning of isolated rabbit cardiomyocytes: effects of glyburide and pinacidil.
Journal of molecular and cellular cardiology 1995;27(8):1765-74.
1995: Cohen M V; Walsh R S; Goto M; Downey J M
Hypoxia preconditions rabbit myocardium via adenosine and catecholamine release.
Journal of molecular and cellular cardiology 1995;27(8):1527-34.
1995: Burckhartt B; Yang X M; Tsuchida A; Mullane K M; Downey J M; Cohen M V
Acadesine extends the window of protection afforded by ischaemic preconditioning in conscious rabbits.
Cardiovascular research 1995;29(5):653-7.
1995: Liu Y; Tsuchida A; Cohen M V; Downey J M
Pretreatment with angiotensin II activates protein kinase C and limits myocardial infarction in isolated rabbit hearts.
Journal of molecular and cellular cardiology 1995;27(3):883-92.
1995: Walsh R S; Borges M; Thornton J D; Cohen M V; Downey J M
Hypoxia preconditions rabbit myocardium by an adenosine receptor-mediated mechanism.
The Canadian journal of cardiology 1995;11(2):141-6.
1995: Downey J M; Cohen M V
Signal transduction in ischemic preconditioning.
Zeitschrift für Kardiologie 1995;84 Suppl 4():77-86.
1994: Ytrehus K; Liu Y; Tsuchida A; Miura T; Liu G S; Yang X M; Herbert D; Cohen M V; Downey J M
Rat and rabbit heart infarction: effects of anesthesia, perfusate, risk zone, and method of infarct sizing.
The American journal of physiology 1994;267(6 Pt 2):H2383-90.
1994: Walsh R S; Tsuchida A; Daly J J; Thornton J D; Cohen M V; Downey J M
Ketamine-xylazine anaesthesia permits a KATP channel antagonist to attenuate preconditioning in rabbit myocardium.
Cardiovascular research 1994;28(9):1337-41.
1994: Tsuchida A; Liu Y; Liu G S; Cohen M V; Downey J M
alpha 1-adrenergic agonists precondition rabbit ischemic myocardium independent of adenosine by direct activation of protein kinase C.
Circulation research 1994;75(3):576-85.
1994: Liu G S; Richards S C; Olsson R A; Mullane K; Walsh R S; Downey J M
Evidence that the adenosine A3 receptor may mediate the protection afforded by preconditioning in the isolated rabbit heart.
Cardiovascular research 1994;28(7):1057-61.
1994: Downey J M; Cohen M V; Ytrehus K; Liu Y
Cellular mechanisms in ischemic preconditioning: the role of adenosine and protein kinase C.
Annals of the New York Academy of Sciences 1994;723():82-98.
1994: Cohen M V; Yang X M; Downey J M
Conscious rabbits become tolerant to multiple episodes of ischemic preconditioning.
Circulation research 1994;74(5):998-1004.
1994: Liu Y; Ytrehus K; Downey J M
Evidence that translocation of protein kinase C is a key event during ischemic preconditioning of rabbit myocardium.
Journal of molecular and cellular cardiology 1994;26(5):661-8.
1994: Tsuchida A; Yang X M; Burckhartt B; Mullane K M; Cohen M V; Downey J M
Acadesine extends the window of protection afforded by ischaemic preconditioning.
Cardiovascular research 1994;28(3):379-83.
1994: Ytrehus K; Liu Y; Downey J M
Preconditioning protects ischemic rabbit heart by protein kinase C activation.
The American journal of physiology 1994;266(3 Pt 2):H1145-52.
1994: Tsuchida A; Thompson R; Olsson R A; Downey J M
The anti-infarct effect of an adenosine A1-selective agonist is diminished after prolonged infusion as is the cardioprotective effect of ischaemic preconditioning in rabbit heart.
Journal of molecular and cellular cardiology 1994;26(3):303-11.
1994: Cohen M V; Yang X M; Liu Y; Snell K S; Downey J M
A new animal model of controlled coronary artery occlusion in conscious rabbits.
Cardiovascular research 1994;28(1):61-5.
1994: Armstrong S; Downey J M; Ganote C E
Preconditioning of isolated rabbit cardiomyocytes: induction by metabolic stress and blockade by the adenosine antagonist SPT and calphostin C, a protein kinase C inhibitor.
Cardiovascular research 1994;28(1):72-7.
1993: Sterling D L; Thornton J D; Swafford A; Gottlieb S F; Bishop S P; Stanley A W; Downey J M
Hyperbaric oxygen limits infarct size in ischemic rabbit myocardium in vivo.
Circulation 1993;88(4 Pt 1):1931-6.
1993: Thornton J D; Daly J F; Cohen M V; Yang X M; Downey J M
Catecholamines can induce adenosine receptor-mediated protection of the myocardium but do not participate in ischemic preconditioning in the rabbit.
Circulation research 1993;73(4):649-55.
1993: Liu Y; Thornton J D; Cohen M V; Downey J M; Schaffer S W
Streptozotocin-induced non-insulin-dependent diabetes protects the heart from infarction.
Circulation 1993;88(3):1273-8.
1993: Ganote C E; Armstrong S; Downey J M
Adenosine and A1 selective agonists offer minimal protection against ischaemic injury to isolated rat cardiomyocytes.
Cardiovascular research 1993;27(9):1670-6.
1993: Downey J M
An explanation for the reported observation that ATP dependent potassium channel openers mimic preconditioning.
Cardiovascular research 1993;27(9):1565.
1993: Thornton J D; Thornton C S; Downey J M
Effect of adenosine receptor blockade: preventing protective preconditioning depends on time of initiation.
The American journal of physiology 1993;265(2 Pt 2):H504-8.
1993: Cohen M V; Downey J M
Ischaemic preconditioning: can the protection be bottled?
Lancet 1993;342(8862):6.
1993: Tsuchida A; Liu G S; Wilborn W H; Downey J M
Pretreatment with the adenosine A1 selective agonist, 2-chloro-N6-cyclopentyladenosine (CCPA), causes a sustained limitation of infarct size in rabbits.
Cardiovascular research 1993;27(4):652-6.
1993: Liu Y; Downey J M
Preconditioning against infarction in the rat heart does not involve a pertussis toxin sensitive G protein.
Cardiovascular research 1993;27(4):608-11.
1993: Yang X M; Arnoult S; Tsuchida A; Cope D; Thornton J D; Daly J F; Cohen M V; Downey J M
The protection of ischaemic preconditioning can be reinstated in the rabbit heart after the initial protection has waned.
Cardiovascular research 1993;27(4):556-8.
1993: Thornton J D; Liu G S; Downey J M
Pretreatment with pertussis toxin blocks the protective effects of preconditioning: evidence for a G-protein mechanism.
Journal of molecular and cellular cardiology 1993;25(3):311-20.
1993: Downey J M; Liu G S; Thornton J D
Adenosine and the anti-infarct effects of preconditioning.
Cardiovascular research 1993;27(1):3-8.
1993: Tsuchida A; Liu G S; Mullane K; Downey J M
Acadesine lowers temporal threshold for the myocardial infarct size limiting effect of preconditioning.
Cardiovascular research 1993;27(1):116-20.
1993: Thornton J D; Thornton C S; Sterling D L; Downey J M
Blockade of ATP-sensitive potassium channels increases infarct size but does not prevent preconditioning in rabbit hearts.
Circulation research 1993;72(1):44-9.
1992: Bunch F T; Thornton J; Cohen M V; Downey J M
Adenosine is an endogenous protectant against stunning during repetitive ischemic episodes in the heart.
American heart journal 1992;124(6):1440-6.
1992: Liu G S; Stanley A W; Downey J M
Ischaemic preconditioning is not dependent on neutrophils or glycolytic substrate at reperfusion in rabbit heart.
Cardiovascular research 1992;26(12):1195-8.
1992: Liu Y; Downey J M
Ischemic preconditioning protects against infarction in rat heart.
The American journal of physiology 1992;263(4 Pt 2):H1107-12.
1992: Parmley L F; Mufti A G; Downey J M
Allopurinol therapy of ischemic heart disease with infarct extension.
The Canadian journal of cardiology 1992;8(3):280-6.
1992: Thornton J D; Liu G S; Olsson R A; Downey J M
Intravenous pretreatment with A1-selective adenosine analogues protects the heart against infarction.
Circulation 1992;85(2):659-65.
1992: Turrens J F; Thornton J; Barnard M L; Snyder S; Liu G; Downey J M
Protection from reperfusion injury by preconditioning hearts does not involve increased antioxidant defenses.
The American journal of physiology 1992;262(2 Pt 2):H585-9.
1991: Van Winkle D M; Swafford A N; Downey J M
Subendocardial coronary compression in beating dog hearts is independent of pressure in the ventricular lumen.
The American journal of physiology 1991;261(2 Pt 2):H500-5.
1991: Liu G S; Thornton J; Van Winkle D M; Stanley A W; Olsson R A; Downey J M
Protection against infarction afforded by preconditioning is mediated by A1 adenosine receptors in rabbit heart.
Circulation 1991;84(1):350-6.
1991: Cohen M V; Liu G S; Downey J M
Preconditioning causes improved wall motion as well as smaller infarcts after transient coronary occlusion in rabbits.
Circulation 1991;84(1):341-9.
1991: Ooiwa H; Janero D R; Stanley A W; Downey J M
Examination of two small-molecule antiperoxidative agents in a rabbit model of postischemic myocardial infarction.
Journal of cardiovascular pharmacology 1991;17(5):761-7.
1991: Ooiwa H; Stanley A; Felaneous-Bylund A C; Wilborn W; Downey J M
Superoxide dismutase conjugated to polyethylene glycol fails to limit myocardial infarct size after 30 min ischemia followed by 72 h of reperfusion in the rabbit.
Journal of molecular and cellular cardiology 1991;23(2):119-25.
1991: Downey J M; Omar B; Ooiwa H; McCord J
Superoxide dismutase therapy for myocardial ischemia.
Free radical research communications 1991;12-13 Pt 2():703-20.
1990: Thornton J; Striplin S; Liu G S; Swafford A; Stanley A W; Van Winkle D M; Downey J M
Inhibition of protein synthesis does not block myocardial protection afforded by preconditioning.
The American journal of physiology 1990;259(6 Pt 2):H1822-5.
1990: Matsuki T; Shirato C; Cohen M V; Downey J M
Oxypurinol limits myocardial infarct size in closed chest dogs without pretreatment.
The Canadian journal of cardiology 1990;6(3):123-9.
1990: Van Winkle D M; Matsuki T; Gad N M; Jordan M C; Downey J M
Left ventricular unloading during reperfusion does not limit myocardial infarct size.
Circulation 1990;81(4):1374-9.
1990: Downey J M
Free radicals and their involvement during long-term myocardial ischemia and reperfusion.
Annual review of physiology 1990;52():487-504.
1990: Omar B A; Gad N M; Jordan M C; Striplin S P; Russell W J; Downey J M; McCord J M
Cardioprotection by Cu,Zn-superoxide dismutase is lost at high doses in the reoxygenated heart.
Free radical biology & medicine 1990;9(6):465-71.
1989: Shirato C; Miura T; Ooiwa H; Toyofuku T; Wilborn W H; Downey J M
Tetrazolium artifactually indicates superoxide dismutase-induced salvage in reperfused rabbit heart.
Journal of molecular and cellular cardiology 1989;21(11):1187-93.
1989: Miura T; Downey J M
Critical collateral bloodflow level for salvage of ischemic myocardium.
The Canadian journal of cardiology 1989;5(4):201-5.
1989: Matsuki T; Cohen M V; Holt G; Ayling J; Hearse D J; Downey J M
Chronic whole body sympathectomy fails to protect ischemic rabbit hearts.
The American journal of physiology 1989;256(5 Pt 2):H1322-7.
1988: Cohen M V; Matsuki T; Downey J M
Pressure-flow characteristics and nutritional capacity of coronary veins in dogs.
The American journal of physiology 1988;255(4 Pt 2):H834-46.
1988: Miura T; Yoshida S; Iimura O; Downey J M
Dobutamine modifies myocardial infarct size through supply-demand balance.
The American journal of physiology 1988;254(5 Pt 2):H855-61.
1988: Miura T; Downey J M
The percentage of the ischemic risk zone infarcting following permanent coronary occlusion is independent of ischemic zone size.
Japanese heart journal 1988;29(3):359-66.
1988: Miura T; Downey J M
Collateral perfusion of ischemic myocardium is inversely related to the size of the ischemic zone.
Basic research in cardiology 1988;83(2):128-36.
1988: Downey J M; Hearse D J; Yellon D M
The role of xanthine oxidase during myocardial ischemia in several species including man.
Journal of molecular and cellular cardiology 1988;20 Suppl 2():55-63.
1988: Miura T; Yellon D M; Kingma J; Downey J M
Protection afforded by allopurinol in the first 24 hours of coronary occlusion is diminished after 48 hours.
Free radical biology & medicine 1988;4(1):25-30.
1987: Downey J M; Miura T; Eddy L J; Chambers D E; Mellert T; Hearse D J; Yellon D M
Xanthine oxidase is not a source of free radicals in the ischemic rabbit heart.
Journal of molecular and cellular cardiology 1987;19(11):1053-60.
1985: Akizuki S; Yoshida S; Chambers D E; Eddy L J; Parmley L F; Yellon D M; Downey J M
Infarct size limitation by the xanthine oxidase inhibitor, allopurinol, in closed-chest dogs with small infarcts.
Cardiovascular research 1985;19(11):686-92.
1985: Chambers D E; Parks D A; Patterson G; Roy R; McCord J M; Yoshida S; Parmley L F; Downey J M
Xanthine oxidase as a source of free radical damage in myocardial ischemia.
Journal of molecular and cellular cardiology 1985;17(2):145-52.
1984: Lee J; Chambers D E; Akizuki S; Downey J M
The role of vascular capacitance in the coronary arteries.
Circulation research 1984;55(6):751-62.

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