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James Downing

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Jennifer Edelmann; Andreas Gerhardinger; Michael Hallek; Karlheinz Holzmann; Jan Korbel; Michael W M Kühn; Peter Lichter; Jing Ma; Daniel Mertens; Florian Miller; Stanley Pounds; Ina Radtke; Stephan Stilgenbauer; Xiaoping Su; Dirk Winkler; Thorsten Zenz; Johannes Bloehdorn; Andreas Bühler; Lars Bullinger; Raymonde Busch; James R Downing; Hartmut Döhner
High-resolution genomic profiling of chronic lymphocytic leukemia reveals new recurrent genomic alterations.
Hiroto Inaba; Jeffrey Jacobsen; Wing Leung; Mihaela Onciu; Stanley Pounds; Ching-Hon Pui; Susana C Raimondi; Raul C Ribeiro; Jeffrey E Rubnitz; Sheila A Shurtleff; Jeffrey W Taub; Kathleen Y Wang; Xueyuan Cao; Elaine Coustan-Smith; Gary V Dahl; Barbara Degar; James R Downing; W Paul Bowman; Dario Campana
Comparative analysis of different approaches to measure treatment response in acute myeloid leukemia.
James R Downing; Li Ding; Timothy J Ley; Elaine R Mardis; Ching-Hon Pui; Richard K Wilson; Jinghui Zhang; William E Evans
The Pediatric Cancer Genome Project.

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2012: Jennifer Edelmann; Andreas Gerhardinger; Michael Hallek; Karlheinz Holzmann; Jan Korbel; Michael W M Kühn; Peter Lichter; Jing Ma; Daniel Mertens; Florian Miller; Stanley Pounds; Ina Radtke; Stephan Stilgenbauer; Xiaoping Su; Dirk Winkler; Thorsten Zenz; Johannes Bloehdorn; Andreas Bühler; Lars Bullinger; Raymonde Busch; James R Downing; Hartmut Döhner
High-resolution genomic profiling of chronic lymphocytic leukemia reveals new recurrent genomic alterations.
Blood 2012;120(24):4783-94.
2012: Hiroto Inaba; Jeffrey Jacobsen; Wing Leung; Mihaela Onciu; Stanley Pounds; Ching-Hon Pui; Susana C Raimondi; Raul C Ribeiro; Jeffrey E Rubnitz; Sheila A Shurtleff; Jeffrey W Taub; Kathleen Y Wang; Xueyuan Cao; Elaine Coustan-Smith; Gary V Dahl; Barbara Degar; James R Downing; W Paul Bowman; Dario Campana
Comparative analysis of different approaches to measure treatment response in acute myeloid leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012;30(29):3625-32.
2012: James R Downing; Li Ding; Timothy J Ley; Elaine R Mardis; Ching-Hon Pui; Richard K Wilson; Jinghui Zhang; William E Evans
The Pediatric Cancer Genome Project.
Nature genetics 2012;44(6):619-22.
2012: Ching-Hon Pui; Raul C Ribeiro; Jeffrey E Rubnitz; John T Sandlund; Sheri L Spunt; Alberto Broniscer; Cheng Cheng; James R Downing; William E Evans; Wayne L Furman; Scott C Howard; Melissa M Hudson; Sima Jeha; Mehmet Kocak; Larry E Kun; Wing Leung; Thomas E Merchant; Monika L Metzger; Alberto S Pappo; Deqing Pei; Amar Gajjar
Treatment outcomes in black and white children with cancer: results from the SEER database and St Jude Children's Research Hospital, 1992 through 2007.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012;30(16):2005-12.
2012: Michael W M Kühn; Jing Ma; Peter Paschka; Stanley Pounds; Asmaa Quessar; Ina Radtke; Raul Ribeiro; Jeffrey E Rubnitz; Richard F Schlenk; Sheila A Shurtleff; Xiaoping Su; Jennifer Edelmann; Verena I Gaidzik; Arnold Ganser; Juliane Gohlke; Salil Goorha; Karlheinz Holzmann; Jürgen Krauter; Jan Krönke; Lars Bullinger; Jinjun Cheng; Hartmut Döhner; Konstanze Döhner; James R Downing
High-resolution genomic profiling of adult and pediatric core-binding factor acute myeloid leukemia reveals new recurrent genomic alterations.
Blood 2012;119(10):e67-75.
2012: Gang Wu; Junyuan Zhang; Jinghui Zhang; Suzanne J Baker; Jared Becksfort; Alberto Broniscer; Li Ding; James R Downing; Michael A Dyer; David W Ellison; Amar Gajjar; Richard J Gilbertson; Robert Huether; Charles Lu; Elaine R Mardis; Troy A McEachron; Charles G Mullighan; Matthew Parker; Barbara S Paugh; Chunxu Qu; Richard K Wilson
Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas.
Nature genetics 2012;44(3):251-3.
2011: Barthelemy Diouf; James R Downing; Siying Chen; Cheng Cheng; Qing Cheng; Meyling Cheok; Yiping Fan; Hui Geng; Peggy Hsieh; Natalia F Krynetskaia; Evgeny Y Krynetskiy; Charles G Mullighan; Deqing Pei; Ching-Hon Pui; Mary V Relling; William E Thierfelder; Wenjian Yang; William E Evans
Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells.
Nature medicine 2011;17(10):1298-303.
2011: A K Andersson; Z Cai; A S Lemoff; J A Lynch; D W Miller; Charles G Mullighan; Stanley Pounds; Ina Radtke; Susana C Raimondi; Raul C Ribeiro; Jeffrey E Rubnitz; J D Schuetz; Brenda A Schulman; Sheila A Shurtleff; B Yan; J Zhang; James R Downing
IDH1 and IDH2 mutations in pediatric acute leukemia.
Leukemia 2011;25(10):1570-7.
2011: Jinghui Zhang; Mignon L Loh; Charles G Mullighan; Gregory H Reaman; Mary V Relling; Malcolm A Smith; Cheryl L Willman; Gang Wu; W Paul Bowman; Kenneth H Buetow; Bruce M Camitta; William L Carroll; I-Ming Chen; Xiang Chen; Meenakshi Devidas; James R Downing; Michael Edmonson; Daniela S Gerhard; Richard C Harvey; Stephen P Hunger
Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group.
Blood 2011;118(11):3080-7.
2011: James R Downing
A new FOXO pathway required for leukemogenesis.
Cell 2011;146(5):669-70.
2011: Jianmin Wang; Lei Wei; Richard K Wilson; David Zhao; Ken Chen; Li Ding; James R Downing; John Easton; Xian Fan; Christopher C Harris; Sue L Heatley; Linda Holmfeldt; Jing Ma; Elaine R Mardis; Charles G Mullighan; Clayton W Naeve; John C Obenauer; Debbie Payne-Turner; Stefan Roberts; Michael C Rusch; Jinghui Zhang
CREST maps somatic structural variation in cancer genomes with base-pair resolution.
Nature methods 2011;8(8):652-4.
2011: A K Mitra; S Pounds; S Raimondi; R C Ribeiro; Jeffrey E Rubnitz; Dario Campana; X Cao; Kristine R Crews; James R Downing; J K Lamba
Impact of genetic variation in FKBP5 on clinical response in pediatric acute myeloid leukemia patients: a pilot study.
Leukemia 2011;25(8):1354-6.
2011: Ching-Hon Pui; Deqing Pei; Dario Campana; W Paul Bowman; John T Sandlund; Sue C Kaste; Raul C Ribeiro; Jeffrey E Rubnitz; Elaine Coustan-Smith; Sima Jeha; Cheng Cheng; Monika L Metzger; Deepa Bhojwani; Hiroto Inaba; Susana C Raimondi; Mihaela Onciu; Scott C Howard; Wing Leung; James R Downing; William E Evans; Mary V Relling
Improved prognosis for older adolescents with acute lymphoblastic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011;29(4):386-91.
2010: Richard C Harvey; Charles G Mullighan; Xuefei Wang; Kevin K Dobbin; George S Davidson; Edward J Bedrick; I-Ming Chen; Susan R Atlas; Huining Kang; Kerem Ar; Carla S Wilson; Walker Wharton; Maurice Murphy; Meenakshi Devidas; Andrew J Carroll; Michael J Borowitz; W Paul Bowman; James R Downing; Mary Relling; Jun Yang; Deepa Bhojwani; William L Carroll; Bruce Camitta; Gregory H Reaman; Malcolm Smith; Stephen P Hunger; Cheryl L Willman
Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome.
Blood 2010;116(23):4874-84.
2010: Richard C Harvey; Charles G Mullighan; I-Ming Chen; Walker Wharton; Fady M Mikhail; Andrew J Carroll; Huining Kang; Wei Liu; Kevin K Dobbin; Malcolm A Smith; William L Carroll; Meenakshi Devidas; W Paul Bowman; Bruce M Camitta; Gregory H Reaman; Stephen P Hunger; James R Downing; Cheryl L Willman
Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia.
Blood 2010;115(26):5312-21.
2010: Jeffrey E Rubnitz; Hiroto Inaba; Gary Dahl; Raul C Ribeiro; W Paul Bowman; Jeffrey W Taub; Stanley Pounds; Bassem I Razzouk; Norman J Lacayo; Xueyuan Cao; Soheil Meshinchi; Barbara Degar; Gladstone Airewele; Susana C Raimondi; Mihaela Onciu; Elaine Coustan-Smith; James R Downing; Wing Leung; Ching-Hon Pui; Dario Campana
Minimal residual disease-directed therapy for childhood acute myeloid leukaemia: results of the AML02 multicentre trial.
The lancet oncology 2010;11(6):543-52.
2010: Ching-Hon Pui; Deqing Pei; John T Sandlund; Raul C Ribeiro; Jeffrey E Rubnitz; Susana C Raimondi; Mihaela Onciu; Dario Campana; Larry E Kun; Sima Jeha; Cheng Cheng; Scott C Howard; Monika L Metzger; D Bhojwani; James R Downing; William Evans; Mary Relling
Long-term results of St Jude Total Therapy Studies 11, 12, 13A, 13B, and 14 for childhood acute lymphoblastic leukemia.
Leukemia 2010;24(2):371-82.
2009: Charles G Mullighan; J Racquel Collins-Underwood; Letha A A Phillips; Michael G Loudin; Wei Liu; Jinghui Zhang; Jing Ma; Elaine Coustan-Smith; Richard C Harvey; Cheryl L Willman; Fady M Mikhail; Julia Meyer; Andrew J Carroll; Richard Williams; Jinjun Cheng; Nyla A Heerema; Giuseppe Basso; Andrea Pession; Ching-Hon Pui; Susana C Raimondi; Stephen P Hunger; James R Downing; William L Carroll; Karen Rabin
Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemia.
Nature genetics 2009;41(11):1243-6.
2009: James R Downing
Can treating the SYK cell cure leukemia?
Cancer cell 2009;16(4):270-1.
2009: James R Downing
Cancer genomes--continuing progress.
The New England journal of medicine 2009;361(11):1111-2.
2009: Stanley Pounds; Cheng Cheng; Xueyuan Cao; Kristine R Crews; William Plunkett; Varsha Gandhi; Jeffrey E Rubnitz; Raul C Ribeiro; James R Downing; Jatinder Lamba
PROMISE: a tool to identify genomic features with a specific biologically interesting pattern of associations with multiple endpoint variables.
Bioinformatics (Oxford, England) 2009;25(16):2013-9.
2009: Ina Radtke; Charles G Mullighan; Masami Ishii; Xiaoping Su; Jinjun Cheng; Jing Ma; Ramapriya Ganti; Zhongling Cai; Salil Goorha; Stanley B Pounds; Xueyuan Cao; Caroline Obert; Jianling Armstrong; Jinghui Zhang; Guangchun Song; Raul C Ribeiro; Jeffrey E Rubnitz; Susana C Raimondi; Sheila A Shurtleff; James R Downing
Genomic analysis reveals few genetic alterations in pediatric acute myeloid leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(31):12944-9.
2009: Sima Jeha; Deqing Pei; Susana C Raimondi; Mihaela Onciu; Dario Campana; Cheng Cheng; John T Sandlund; Raul C Ribeiro; Jeffrey E Rubnitz; Scott C Howard; James R Downing; William Evans; Mary Relling; Ching-Hon Pui
Increased risk for CNS relapse in pre-B cell leukemia with the t(1;19)/TCF3-PBX1.
Leukemia 2009;23(8):1406-9.
2009: Jeffrey E Rubnitz; Kristine R Crews; Stanley Pounds; S Yang; Dario Campana; Varsha Gandhi; Susana C Raimondi; James R Downing; Bassem I Razzouk; Ching-Hon Pui; Raul C Ribeiro
Combination of cladribine and cytarabine is effective for childhood acute myeloid leukemia: results of the St Jude AML97 trial.
Leukemia 2009;23(8):1410-6.
2009: Charles G Mullighan; James R Downing
Genome-wide profiling of genetic alterations in acute lymphoblastic leukemia: recent insights and future directions.
Leukemia 2009;23(7):1209-18.
2009: Ching-Hon Pui; Dario Campana; Deqing Pei; W Paul Bowman; John T Sandlund; Sue C Kaste; Raul C Ribeiro; Jeffrey E Rubnitz; Susana C Raimondi; Mihaela Onciu; Elaine Coustan-Smith; Larry E Kun; Sima Jeha; Cheng Cheng; Scott C Howard; Vickey Simmons; Amy Bayles; Monika L Metzger; James M Boyett; Wing Leung; Rupert Handgretinger; James R Downing; William Evans; Mary Relling
Treating childhood acute lymphoblastic leukemia without cranial irradiation.
The New England journal of medicine 2009;360(26):2730-41.
2009: Charles G Mullighan; Jinghui Zhang; Richard C Harvey; J Racquel Collins-Underwood; Brenda A Schulman; Letha A Phillips; Sarah K Tasian; Mignon L Loh; Xiaoping Su; Wei Liu; Meenakshi Devidas; Susan R Atlas; I-Ming Chen; Robert J Clifford; Daniela S Gerhard; William L Carroll; Gregory H Reaman; Malcolm Smith; James R Downing; Stephen P Hunger; Cheryl L Willman
JAK mutations in high-risk childhood acute lymphoblastic leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(23):9414-8.
2009: Jeffrey E Rubnitz; Mihaela Onciu; Stanley Pounds; Sheila A Shurtleff; Xueyuan Cao; Susana C Raimondi; Frederick G. Behm; Dario Campana; Bassem I Razzouk; Raul C Ribeiro; James R Downing; Ching-Hon Pui
Acute mixed lineage leukemia in children: the experience of St Jude Children's Research Hospital.
Blood 2009;113(21):5083-9.
2009: Deborah French; Wenjian Yang; Cheng Cheng; Susana C Raimondi; Charles G Mullighan; James R Downing; William Evans; Ching-Hon Pui; Mary Relling
Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia.
Blood 2009;113(19):4512-20.
2009: Elaine Coustan-Smith; Charles G Mullighan; Mihaela Onciu; Frederick G. Behm; Susana C Raimondi; Deqing Pei; Cheng Cheng; Xiaoping Su; Jeffrey E Rubnitz; Giuseppe Basso; Andrea Biondi; Ching-Hon Pui; James R Downing; Dario Campana
Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia.
The lancet oncology 2009;10(2):147-56.
2009: Stan Pounds; Cheng Cheng; Charles G Mullighan; Susana C Raimondi; Sheila Shurtleff; James R Downing
Reference alignment of SNP microarray signals for copy number analysis of tumors.
Bioinformatics (Oxford, England) 2009;25(3):315-21.
2009: Charles G Mullighan; Xiaoping Su; Jinghui Zhang; Ina Radtke; Letha Phillips; Christopher B Miller; Jing Ma; Wei Liu; Cheng Cheng; Brenda A Schulman; Richard C Harvey; I-Ming Chen; Robert J Clifford; William L Carroll; Gregory Reaman; W Paul Bowman; Meenakshi Devidas; Daniela S Gerhard; Wenjian Yang; Mary Relling; Sheila A Shurtleff; Dario Campana; Michael J Borowitz; Ching-Hon Pui; Malcolm Smith; Stephen P Hunger; Cheryl L Willman; James R Downing
Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia.
The New England journal of medicine 2009;360(5):470-80.
2009: Jun J Yang; Cheng Cheng; Wenjian Yang; Deqing Pei; Xueyuan Cao; Yiping Fan; Stanley B Pounds; Geoffrey Neale; Lisa R Treviño; Deborah French; Dario Campana; James R Downing; William Evans; Ching-Hon Pui; Meenakshi Devidas; W P Bowman; Bruce M Camitta; Cheryl L Willman; Stella M Davies; Michael J Borowitz; William L Carroll; Stephen P Hunger; Mary Relling
Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia.
JAMA : the journal of the American Medical Association 2009;301(4):393-403.
2008: Charles G Mullighan; Letha Phillips; Xiaoping Su; Jing Ma; Christopher B Miller; Sheila A Shurtleff; James R Downing
Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia.
Science (New York, N.Y.) 2008;322(5906):1377-80.
2008: Charles G Mullighan; Richard Williams; James R Downing; Charles J Sherr
Failure of CDKN2A/B (INK4A/B-ARF)-mediated tumor suppression and resistance to targeted therapy in acute lymphoblastic leukemia induced by BCR-ABL.
Genes & development 2008;22(11):1411-5.
2008: James R Downing
Targeted therapy in leukemia.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2008;21 Suppl 2():S2-7.
2008: Charles G Mullighan; Christopher B Miller; Ina Radtke; Letha Phillips; James Dalton; Jing Ma; Deborah White; Timothy P Hughes; Michelle M Le Beau; Ching-Hon Pui; Mary Relling; Sheila A Shurtleff; James R Downing
BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros.
Nature 2008;453(7191):110-4.
2008: Deborah French; Wenjian Yang; Leo H Hamilton; Geoffrey Neale; Yiping Fan; James R Downing; Nancy J Cox; Ching-Hon Pui; William Evans; Mary Relling
Concordant gene expression in leukemia cells and normal leukocytes is associated with germline cis-SNPs.
PloS one 2008;3(5):e2144.
2007: Charles G Mullighan; A Kennedy; X Zhou; Ina Radtke; Letha Phillips; Sheila A Shurtleff; James R Downing
Pediatric acute myeloid leukemia with NPM1 mutations is characterized by a gene expression profile with dysregulated HOX gene expression distinct from MLL-rearranged leukemias.
Leukemia 2007;21(9):2000-9.
2007: Christian Flotho; Doris Steinemann; Charles G Mullighan; G Neale; K Mayer; Christian P Kratz; Brigitte Schlegelberger; James R Downing; Charlotte M Niemeyer
Genome-wide single-nucleotide polymorphism analysis in juvenile myelomonocytic leukemia identifies uniparental disomy surrounding the NF1 locus in cases associated with neurofibromatosis but not in cases with mutant RAS or PTPN11.
Oncogene 2007;26(39):5816-21.
2007: Christian Flotho; Elaine Coustan-Smith; Deqing Pei; Cheng Cheng; Guangchun Song; Ching-Hon Pui; James R Downing; Dario Campana
A set of genes that regulate cell proliferation predicts treatment outcome in childhood acute lymphoblastic leukemia.
Blood 2007;110(4):1271-7.
2007: cintia carella; Jacqueline Bonten; Sema Sirma; T A Kranenburg; S Terranova; R Klein-Geltink; Sheila A Shurtleff; James R Downing; Ellen C Zwarthoff; P P Liu; Gerard C Grosveld
MN1 overexpression is an important step in the development of inv(16) AML.
Leukemia 2007;21(8):1679-90.
2007: Charles G Mullighan; Salil Goorha; Ina Radtke; Christopher B Miller; Elaine Coustan-Smith; James D Dalton; Kevin Girtman; Susan Mathew; Jing Ma; Stanley Pounds; Xiaoping Su; Ching-Hon Pui; Mary Relling; William Evans; Sheila A Shurtleff; James R Downing
Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia.
Nature 2007;446(7137):758-64.
2006: Amy Holleman; Monique L den Boer; Meyling H Cheok; Karin M Kazemier; Deqing Pei; James R Downing; Gritta E Janka-Schaub; Ulrich Göbel; Ulrike B Graubner; Ching-Hon Pui; William Evans; Rob Pieters
Expression of the outcome predictor in acute leukemia 1 (OPAL1) gene is not an independent prognostic factor in patients treated according to COALL or St Jude protocols.
Blood 2006;108(6):1984-90.
2006: Christian Flotho; Elaine Coustan-Smith; Deqing Pei; Shotaro Iwamoto; Guangchun Song; Cheng Cheng; Ching-Hon Pui; James R Downing; Dario Campana
Genes contributing to minimal residual disease in childhood acute lymphoblastic leukemia: prognostic significance of CASP8AP2.
Blood 2006;108(3):1050-7.
2006: A Bogni; Cheng Cheng; W Liu; Wenjian Yang; J Pfeffer; Suraj Mukatira; D French; James R Downing; Ching-Hon Pui; Mary Relling
Genome-wide approach to identify risk factors for therapy-related myeloid leukemia.
Leukemia 2006;20(2):239-46.
2006: James R Downing; Charles G Mullighan
Tumor-specific genetic lesions and their influence on therapy in pediatric acute lymphoblastic leukemia.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2006;():118-22, 508.
2005: Ching-Hon Pui; Deqing Pei; John T Sandlund; Dario Campana; Raul C Ribeiro; Bassem I Razzouk; Jeffrey E Rubnitz; Scott C Howard; Nobuko Hijiya; Sima Jeha; Cheng Cheng; James R Downing; William Evans; Mary Relling; Melissa Hudson
Risk of adverse events after completion of therapy for childhood acute lymphoblastic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(31):7936-41.
2005: Charles G Mullighan; Christian Flotho; James R Downing
Genomic assessment of pediatric acute leukemia.
Cancer journal (Sudbury, Mass.) 2005;11(4):268-82.
2004: Weili Sun; James R Downing
Haploinsufficiency of AML1 results in a decrease in the number of LTR-HSCs while simultaneously inducing an increase in more mature progenitors.
Blood 2004;104(12):3565-72.
2004: Mary Elizabeth Ross; Rami Mahfouz; Mihaela Onciu; Hsi-Che Liu; Xiaodong Zhou; Guangchun Song; Sheila A Shurtleff; Stanley Pounds; Cheng Cheng; Jing Ma; Raul C Ribeiro; Jeffrey E Rubnitz; Kevin Girtman; W Kent Williams; Susana C Raimondi; Der-Cherng Liang; Lee-Yung Shih; Ching-Hon Pui; James R Downing
Gene expression profiling of pediatric acute myelogenous leukemia.
Blood 2004;104(12):3679-87.
2004: Ching-Hon Pui; John T Sandlund; Deqing Pei; Dario Campana; Jaime Rivera; Raul C Ribeiro; Jeffrey E Rubnitz; Bassem I Razzouk; Scott C Howard; Melissa M Hudson; Cheng Cheng; Larry E Kun; Susana C Raimondi; Frederick G. Behm; James R Downing; Mary Relling; William Evans
Improved outcome for children with acute lymphoblastic leukemia: results of Total Therapy Study XIIIB at St Jude Children's Research Hospital.
Blood 2004;104(9):2690-6.
2004: James R Downing
TGF-beta signaling, tumor suppression, and acute lymphoblastic leukemia.
The New England journal of medicine 2004;351(6):528-30.
2004: Chihaya Imai; Mary Elizabeth Ross; G Reid; Elaine Coustan-Smith; Kirk R Schultz; Ching-Hon Pui; James R Downing; Dario Campana
Expression of the adaptor protein BLNK/SLP-65 in childhood acute lymphoblastic leukemia.
Leukemia 2004;18(5):922-5.
2004: Ching-Hon Pui; Mary Relling; James R Downing
Acute lymphoblastic leukemia.
The New England journal of medicine 2004;350(15):1535-48.
2004: Robert B Lorsbach; Jennifer Moore; Sonny O Ang; Weili Sun; Noel Lenny; James R Downing
Role of RUNX1 in adult hematopoiesis: analysis of RUNX1-IRES-GFP knock-in mice reveals differential lineage expression.
Blood 2004;103(7):2522-9.
2003: Ching-Hon Pui; John T Sandlund; Deqing Pei; Jaime Rivera; Scott C Howard; Raul C Ribeiro; Jeffrey E Rubnitz; Bassem I Razzouk; Melissa M Hudson; Cheng Cheng; Susana C Raimondi; Frederick G. Behm; James R Downing; Mary Relling; William Evans
Results of therapy for acute lymphoblastic leukemia in black and white children.
JAMA : the journal of the American Medical Association 2003;290(15):2001-7.
2003: Mary Elizabeth Ross; Xiaodong Zhou; Guangchun Song; Sheila A Shurtleff; Kevin Girtman; W Kent Williams; Hsi-Che Liu; Rami Mahfouz; Susana C Raimondi; Noel Lenny; Anami Patel; James R Downing
Classification of pediatric acute lymphoblastic leukemia by gene expression profiling.
Blood 2003;102(8):2951-9.
2003: Elaine Coustan-Smith; Raul C Ribeiro; Jeffrey E Rubnitz; Bassem I Razzouk; Ching-Hon Pui; Stanley Pounds; Martin Andreansky; Frederick G. Behm; Susana C Raimondi; Sheila A Shurtleff; James R Downing; Dario Campana
Clinical significance of residual disease during treatment in childhood acute myeloid leukaemia.
British journal of haematology 2003;123(2):243-52.
2003: Mihaela Onciu; Frederick G. Behm; James R Downing; Sheila A Shurtleff; Susana C Raimondi; Zhigui Ma; Stephan W Morris; Wren Kennedy; Sandra C Jones; John T Sandlund
ALK-positive plasmablastic B-cell lymphoma with expression of the NPM-ALK fusion transcript: report of 2 cases.
Blood 2003;102(7):2642-4.
2003: Meyling H Cheok; Wenjian Yang; Ching-Hon Pui; James R Downing; Cheng Cheng; Clayton W Naeve; Mary Relling; William Evans
Treatment-specific changes in gene expression discriminate in vivo drug response in human leukemia cells.
Nature genetics 2003;34(1):85-90.
2003: Robert B Lorsbach; J Moore; S Mathew; Susana C Raimondi; Suraj Mukatira; James R Downing
TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23).
Leukemia 2003;17(3):637-41.
2003: James R Downing
The core-binding factor leukemias: lessons learned from murine models.
Current opinion in genetics & development 2003;13(1):48-54.
2003: Jinyan Li; Huiqing Liu; James R Downing; A E J Yeoh; Limsoon Wong
Simple rules underlying gene expression profiles of more than six subtypes of acute lymphoblastic leukemia (ALL) patients.
Bioinformatics (Oxford, England) 2003;19(1):71-8.
2003: D Ashley Hill; Shannon E Riedley; Anami R Patel; Sheila A Shurtleff; Jennifer Hyer; Alvida M Cain; Catherine A Billups; James R Downing; Alberto S Pappo
Real-time polymerase chain reaction as an aid for the detection of SYT-SSX1 and SYT-SSX2 transcripts in fresh and archival pediatric synovial sarcoma specimens: report of 25 cases from St. Jude Children's Research Hospital.
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society 2003;6(1):24-34.
2002: James R Downing; Kevin Shannon
Acute leukemia: a pediatric perspective.
Cancer cell 2002;2(6):437-45.
2002: Jeffrey E Rubnitz; Susana C Raimondi; A R Halbert; Xin Tong; Deo Kumar Srivastava; Bassem I Razzouk; Ching-Hon Pui; James R Downing; Raul C Ribeiro; Frederick G. Behm
Characteristics and outcome of t(8;21)-positive childhood acute myeloid leukemia: a single institution's experience.
Leukemia 2002;16(10):2072-7.
2002: Jeffrey E Rubnitz; Susana C Raimondi; Xin Tong; Deo Kumar Srivastava; Bassem I Razzouk; Sheila A Shurtleff; James R Downing; Ching-Hon Pui; Raul C Ribeiro; Frederick G. Behm
Favorable impact of the t(9;11) in childhood acute myeloid leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(9):2302-9.
2002: Eng-Juh Yeoh; Mary Elizabeth Ross; Sheila A Shurtleff; W Kent Williams; Divyen Patel; Rami Mahfouz; Frederick G. Behm; Susana C Raimondi; Mary Relling; Anami Patel; Cheng Cheng; Dario Campana; Dawn Wilkins; Xiaodong Zhou; Jinyan Li; Huiqing Liu; Ching-Hon Pui; William Evans; Clayton W Naeve; Limsoon Wong; James R Downing
Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling.
Cancer cell 2002;1(2):133-43.
2002: Masakazu Higuchi; Darin O'Brien; Parasakthy Kumaravelu; Noel Lenny; Eng-Juh Yeoh; James R Downing
Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia.
Cancer cell 2002;1(1):63-74.
2001: Robert B Lorsbach; James R Downing
The role of the AML1 transcription factor in leukemogenesis.
International journal of hematology 2001;74(3):258-65.
2001: Joseph M Amann; John Nip; DK Strom; Bart Lutterbach; H Harada; Noel Lenny; James R Downing; Shari Meyers; Scott W Hiebert
ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain.
Molecular and cellular biology 2001;21(19):6470-83.
2001: James R Downing
AML1/CBFbeta transcription complex: its role in normal hematopoiesis and leukemia.
Leukemia 2001;15(4):664-5.
2001: Lee-Yung Shih; Jen-Fen Fu; Sheila A Shurtleff; S W Morris; James R Downing
Lack of BCL10 mutations in multiple myeloma and plasma cell leukemia.
Genes, chromosomes & cancer 2001;30(4):402-6.
2001: Susan Mathew; P H Rao; James Dalton; James R Downing; Susana C Raimondi
Multicolor spectral karyotyping identifies novel translocations in childhood acute lymphoblastic leukemia.
Leukemia 2001;15(3):468-72.
2001: Uma H Athale; Sheila A Shurtleff; Jesse J Jenkins; CA Poquette; Ming Tan; James R Downing; Alberto S Pappo
Use of reverse transcriptase polymerase chain reaction for diagnosis and staging of alveolar rhabdomyosarcoma, Ewing sarcoma family of tumors, and desmoplastic small round cell tumor.
Journal of pediatric hematology/oncology 2001;23(2):99-104.
2001: Sheila A Shurtleff; James R Downing; Stephan W Morris
NPM-ALK Reverse Transcriptase-Polymerase Chain Reaction for Detecting the t(2;5) of Non-Hodgkin's Lymphoma.
Methods in molecular medicine 2001;55():157-76.
2000: Miguel Bonilla; N Moreno; N Marina; G deReyes; Sheila A Shurtleff; James R Downing; Frederick G. Behm; Patricia L Harrison; Raul C Ribeiro; O Peña; William M Crist; Federico Antillon
Acute lymphoblastic leukemia in a developing country: preliminary results of a nonrandomized clinical trial in El Salvador.
Journal of pediatric hematology/oncology 2000;22(6):495-501.
2000: James R Downing; M Higuchi; Noel Lenny; A E J Yeoh
Alterations of the AML1 transcription factor in human leukemia.
Seminars in cell & developmental biology 2000;11(5):347-60.
2000: DK Strom; John Nip; JJ Westendorf; Bryan Linggi; Bart Lutterbach; James R Downing; Noel Lenny; Scott W Hiebert
Expression of the AML-1 oncogene shortens the G(1) phase of the cell cycle.
The Journal of biological chemistry 2000;275(5):3438-45.
1999: Randy Fenrick; Joseph M Amann; Bart Lutterbach; Lilin Wang; JJ Westendorf; James R Downing; Scott W Hiebert
Both TEL and AML-1 contribute repression domains to the t(12;21) fusion protein.
Molecular and cellular biology 1999;19(10):6566-74.
1999: Jeffrey E Rubnitz; James R Downing; Ching-Hon Pui
Significance of the TEL-AML fusion gene in childhood AML.
Leukemia 1999;13(9):1470-1.
1999: James R Downing
The AML1-ETO chimaeric transcription factor in acute myeloid leukaemia: biology and clinical significance.
British journal of haematology 1999;106(2):296-308.
1999: H Harada; Y Harada; D P O'Brien; D S Rice; Clayton W Naeve; James R Downing
HERF1, a novel hematopoiesis-specific RING finger protein, is required for terminal differentiation of erythroid cells.
Molecular and cellular biology 1999;19(5):3808-15.
1999: S M Bodner; Clayton W Naeve; Karen M Rakestraw; B G Jones; Virginia Valentine; Marcus B Valentine; Frederick W Luthardt; C L Willman; Susana C Raimondi; James R Downing; M F Roussel; C J Sherr; A Thomas Look
Cloning and chromosomal localization of the gene encoding human cyclin D-binding Myb-like protein (hDMP1).
Gene 1999;229(1-2):223-8.
1999: Jeffrey E Rubnitz; Bruce M Camitta; Hazem H Mahmoud; Susana C Raimondi; Andrew J Carroll; Michael J Borowitz; Jonathan J Shuster; Michael P Link; D Jeanette Pullen; James R Downing; Frederick G. Behm; Ching-Hon Pui
Childhood acute lymphoblastic leukemia with the MLL-ENL fusion and t(11;19)(q23;p13.3) translocation.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1999;17(1):191-6.
1999: Jeffrey E Rubnitz; Ching-Hon Pui; James R Downing
The role of TEL fusion genes in pediatric leukemias.
Leukemia 1999;13(1):6-13.
1999: Jeffrey E Rubnitz; Frederick G. Behm; D Wichlan; C Ryan; John T Sandlund; Raul C Ribeiro; Jaime Rivera; Michael L Hancock; Mary Relling; William Evans; Ching-Hon Pui; James R Downing
Low frequency of TEL-AML1 in relapsed acute lymphoblastic leukemia supports a favorable prognosis for this genetic subgroup.
Leukemia 1999;13(1):19-21.
1998: Ching-Hon Pui; Jeffrey E Rubnitz; Michael L Hancock; James R Downing; Susana C Raimondi; Jaime Rivera; John T Sandlund; Raul C Ribeiro; DR Head; Mary Relling; William Evans; Frederick G. Behm
Reappraisal of the clinical and biologic significance of myeloid-associated antigen expression in childhood acute lymphoblastic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998;16(12):3768-73.
1998: P Scurto; M Hsu Rocha; J R Kane; W Kent Williams; D M Haney; W P Conn; Sheila A Shurtleff; James R Downing
A multiplex RT-PCR assay for the detection of chimeric transcripts encoded by the risk-stratifying translocations of pediatric acute lymphoblastic leukemia.
Leukemia 1998;12(12):1994-2005.
1998: T Okuda; Z Cai; S Yang; Noel Lenny; C J Lyu; J M van Deursen; H Harada; James R Downing
Expression of a knocked-in AML1-ETO leukemia gene inhibits the establishment of normal definitive hematopoiesis and directly generates dysplastic hematopoietic progenitors.
Blood 1998;91(9):3134-43.
1998: Jeffrey E Rubnitz; James R Downing; W M Crist
Pathobiology and clinical significance of molecular genetic findings in childhood tumors.
Advances in pediatrics 1998;45():315-36.
1998: JJ Westendorf; C M Yamamoto; Noel Lenny; James R Downing; Michael Selsted; Scott W Hiebert
The t(8;21) fusion product, AML-1-ETO, associates with C/EBP-alpha, inhibits C/EBP-alpha-dependent transcription, and blocks granulocytic differentiation.
Molecular and cellular biology 1998;18(1):322-33.
1997: Susana C Raimondi; Sheila A Shurtleff; James R Downing; Jeffrey E Rubnitz; S Mathew; M Hancock; Ching-Hon Pui; Jaime Rivera; Gerard C Grosveld; Frederick G. Behm
12p abnormalities and the TEL gene (ETV6) in childhood acute lymphoblastic leukemia.
Blood 1997;90(11):4559-66.
1997: T Kamijo; Frederique Zindy; Martine F Roussel; Dawn E Quelle; James R Downing; RA Ashmun; Gerard C Grosveld; Charles J Sherr
Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF.
Cell 1997;91(5):649-59.
1997: Federico Antillon; Sue C Kaste; Jesse J Jenkins; Sheila A Shurtleff; Thomas E Merchant; James R Downing; Alberto S Pappo
Primitive neuroectodermal tumor of bone as a second malignant neoplasm in a child previously treated for acute lymphoblastic leukemia.
Journal of pediatric hematology/oncology 1997;19(5):473-6.
1997: Jeffrey E Rubnitz; Frederick G. Behm; Ching-Hon Pui; William Evans; Mary Relling; Susana C Raimondi; Patricia L Harrison; John T Sandlund; Raul C Ribeiro; G Grosveld; James R Downing
Genetic studies of childhood acute lymphoblastic leukemia with emphasis on p16, MLL, and ETV6 gene abnormalities: results of St Jude Total Therapy Study XII.
Leukemia 1997;11(8):1201-6.
1997: L Venkateswaran; Jesse J Jenkins; Sue C Kaste; Sheila A Shurtleff; James R Downing; Alberto S Pappo
Disseminated intrathoracic desmoplastic small round-cell tumor: a case report.
Journal of pediatric hematology/oncology 1997;19(2):172-5.
1997: Jeffrey E Rubnitz; James R Downing; Ching-Hon Pui; Sheila A Shurtleff; Susana C Raimondi; William Evans; DR Head; William M Crist; Jaime Rivera; Michael L Hancock; James M Boyett; Arjan Buijs; Gerard C Grosveld; Frederick G. Behm
TEL gene rearrangement in acute lymphoblastic leukemia: a new genetic marker with prognostic significance.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1997;15(3):1150-7.
1997: Jeffrey E Rubnitz; Jonathan J Shuster; Vita J Land; Michael P Link; D Jeanette Pullen; Bruce M Camitta; Ching-Hon Pui; James R Downing; Frederick G. Behm
Case-control study suggests a favorable impact of TEL rearrangement in patients with B-lineage acute lymphoblastic leukemia treated with antimetabolite-based therapy: a Pediatric Oncology Group study.
Blood 1997;89(4):1143-6.
1996: Lee-Yung Shih; T B Chou; Der-Cherng Liang; Y S Tzeng; Jeffrey E Rubnitz; James R Downing; Ching-Hon Pui
Lack of TEL-AML1 fusion transcript resulting from a cryptic t(12;21) in adult B lineage acute lymphoblastic leukemia in Taiwan.
Leukemia 1996;10(9):1456-8.
1996: J R Kane; D R Head; L Balazs; M G Hulshof; T A Motroni; Susana C Raimondi; Andrew J Carroll; Frederick G. Behm; Robert A Krance; Sheila A Shurtleff; James R Downing
Molecular analysis of the PML/RAR alpha chimeric gene in pediatric acute promyelocytic leukemia.
Leukemia 1996;10(8):1296-302.
1996: Der-Cherng Liang; T B Chou; J S Chen; Sheila A Shurtleff; Jeffrey E Rubnitz; James R Downing; Ching-Hon Pui; Lee-Yung Shih
High incidence of TEL/AML1 fusion resulting from a cryptic t(12;21) in childhood B-lineage acute lymphoblastic leukemia in Taiwan.
Leukemia 1996;10(6):991-3.
1996: Jeffrey E Rubnitz; Frederick G. Behm; A M Curcio-Brint; R P Pinheiro; Andrew J Carroll; Susana C Raimondi; Sheila A Shurtleff; James R Downing
Molecular analysis of t(11;19) breakpoints in childhood acute leukemias.
Blood 1996;87(11):4804-8.
1996: Scott W Hiebert; W Sun; James Davis; Todd R Golub; Sheila A Shurtleff; Arjan Buijs; James R Downing; Gerard C Grosveld; M F Roussell; D Gary Gilliland; Noel Lenny; S Meyers
The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription.
Molecular and cellular biology 1996;16(4):1349-55.
1996: Frederick G. Behm; Susana C Raimondi; J L Frestedt; Q Liu; W M Crist; James R Downing; G K Rivera; J H Kersey; Ching-Hon Pui
Rearrangement of the MLL gene confers a poor prognosis in childhood acute lymphoblastic leukemia, regardless of presenting age.
Blood 1996;87(7):2870-7.
1996: T Okuda; Jan M A van Deursen; S W Hiebert; Gerard C Grosveld; James R Downing
AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis.
Cell 1996;84(2):321-30.
1996: Sheila A Shurtleff; James R Downing; Stephan W Morris
NPM-ALK Reverse Transcriptase-Polymerase Chain Reaction Analysis for Detection of the t(2;5) Translocation of Non-Hodgkin's Lymphoma.
Methods in molecular medicine 1996;6():75-89.
1996: Scott W Hiebert; James R Downing; Noel Lenny; S Meyers
Transcriptional regulation by the t(8;21) fusion protein, AML-1/ETO.
Current topics in microbiology and immunology 1996;211():253-8.
1996: Jeffrey E Rubnitz; Frederick G. Behm; James R Downing
11q23 rearrangements in acute leukemia.
Leukemia 1996;10(1):74-82.
1995: Sheila A Shurtleff; Arjan Buijs; Frederick G. Behm; Jeffrey E Rubnitz; Susana C Raimondi; Michael L Hancock; G C Chan; Ching-Hon Pui; Gerard C Grosveld; James R Downing
TEL/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis.
Leukemia 1995;9(12):1985-9.
1995: T Okuda; H Hirai; Virginia Valentine; Sheila A Shurtleff; Vincent J Kidd; Jill Lahti; Charles J Sherr; James R Downing
Molecular cloning, expression pattern, and chromosomal localization of human CDKN2D/INK4d, an inhibitor of cyclin D-dependent kinases.
Genomics 1995;29(3):623-30.
1995: Susana C Raimondi; J L Frestedt; Ching-Hon Pui; James R Downing; D R Head; J H Kersey; Frederick G. Behm
Acute lymphoblastic leukemias with deletion of 11q23 or a novel inversion (11)(p13q23) lack MLL gene rearrangements and have favorable clinical features.
Blood 1995;86(5):1881-6.
1995: James R Downing; Sheila A Shurtleff; M Zielenska; A M Curcio-Brint; Frederick G. Behm; D R Head; John T Sandlund; D D Weisenburger; A E Kossakowska; P Thorner
Molecular detection of the (2;5) translocation of non-Hodgkin's lymphoma by reverse transcriptase-polymerase chain reaction.
Blood 1995;85(12):3416-22.
1995: L V Filatov; Frederick G. Behm; Ching-Hon Pui; D R Head; James R Downing; Susana C Raimondi
Childhood acute lymphoblastic leukemia with equivocal chromosome markers of the t(1;19) translocation.
Genes, chromosomes & cancer 1995;13(2):99-103.
1995: James R Downing; A Khandekar; Sheila A Shurtleff; D R Head; David M Parham; B L Webber; Alberto S Pappo; M G Hulshof; W P Conn; DN Shapiro
Multiplex RT-PCR assay for the differential diagnosis of alveolar rhabdomyosarcoma and Ewing's sarcoma.
The American journal of pathology 1995;146(3):626-34.
1994: fatih uckun; James R Downing; LM Chelstrom; R Gunther; M Ryan; J Simon; A J Carroll; L Tuel-Ahlgren; W M Crist
Human t(4;11)(q21;q23) acute lymphoblastic leukemia in mice with severe combined immunodeficiency.
Blood 1994;84(3):859-65.
1994: David M Parham; DN Shapiro; James R Downing; B L Webber; E C Douglass
Solid alveolar rhabdomyosarcomas with the t(2;13). Report of two cases with diagnostic implications.
The American journal of surgical pathology 1994;18(5):474-8.
1994: Ching-Hon Pui; Frederick G. Behm; James R Downing; Michael L Hancock; Sheila A Shurtleff; Raul C Ribeiro; D R Head; Hazem H Mahmoud; John T Sandlund; Wayne L Furman
11q23/MLL rearrangement confers a poor prognosis in infants with acute lymphoblastic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1994;12(5):909-15.
1994: T Okuda; Virginia Valentine; DN Shapiro; James R Downing
Cloning of genomic loci and chromosomal localization of the human PCTAIRE-1 and -3 protein kinase genes.
Genomics 1994;21(1):217-21.
1994: James R Downing; D R Head; Susana C Raimondi; Andrew J Carroll; A M Curcio-Brint; T A Motroni; M G Hulshof; D J Pullen; P H Domer
The der(11)-encoded MLL/AF-4 fusion transcript is consistently detected in t(4;11)(q21;q23)-containing acute lymphoblastic leukemia.
Blood 1994;83(2):330-5.
1993: James R Downing; D R Head; David M Parham; E C Douglass; M G Hulshof; M P Link; T A Motroni; Holcombe E Grier; A M Curcio-Brint; DN Shapiro
Detection of the (11;22)(q24;q12) translocation of Ewing's sarcoma and peripheral neuroectodermal tumor by reverse transcription polymerase chain reaction.
The American journal of pathology 1993;143(5):1294-300.
1993: DN Shapiro; JE Sublett; B Li; James R Downing; Clayton W Naeve
Fusion of PAX3 to a member of the forkhead family of transcription factors in human alveolar rhabdomyosarcoma.
Cancer research 1993;53(21):5108-12.
1993: S Meyers; James R Downing; Scott W Hiebert
Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions.
Molecular and cellular biology 1993;13(10):6336-45.
1993: S G Gad; D F Callen; B Kuss; James R Downing; Frederick G. Behm; D Head; Raul C Ribeiro; Susana C Raimondi
Identification of an inversion 16 coexisting with an isochromosome 22q by in situ hybridization in a case of childhood AML M4e.
Leukemia 1993;7(10):1658-62.
1993: James R Downing; D R Head; A M Curcio-Brint; M G Hulshof; T A Motroni; Susana C Raimondi; Andrew J Carroll; Harry A Drabkin; C Willman; K S Theil
An AML1/ETO fusion transcript is consistently detected by RNA-based polymerase chain reaction in acute myelogenous leukemia containing the (8;21)(q22;q22) translocation.
Blood 1993;81(11):2860-5.
1993: fatih uckun; James R Downing; R Gunther; LM Chelstrom; D Finnegan; V J Land; Michael J Borowitz; A J Carroll; W M Crist
Human t(1;19)(q23;p13) pre-B acute lymphoblastic leukemia in mice with severe combined immunodeficiency.
Blood 1993;81(11):3052-62.
1992: T Okuda; J L Cleveland; James R Downing
PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family.
Oncogene 1992;7(11):2249-58.
1991: James R Downing; Sheila A Shurtleff; Charles J Sherr
Peptide antisera to human colony-stimulating factor 1 receptor detect ligand-induced conformational changes and a binding site for phosphatidylinositol 3-kinase.
Molecular and cellular biology 1991;11(5):2489-95.
1991: James R Downing; A B Reynolds
PDGF, CSF-1, and EGF induce tyrosine phosphorylation of p120, a pp60src transformation-associated substrate.
Oncogene 1991;6(4):607-13.
1991: Charles J Sherr; G V Borzillo; J Kato; Sheila A Shurtleff; James R Downing; Martine F Roussel
Regulation of cell growth and differentiation by the colony-stimulating factor 1 receptor.
Seminars in hematology 1991;28(2):143-51.
1990: Martine F Roussel; Sheila A Shurtleff; James R Downing; Charles J Sherr
A point mutation at tyrosine-809 in the human colony-stimulating factor 1 receptor impairs mitogenesis without abrogating tyrosine kinase activity, association with phosphatidylinositol 3-kinase, or induction of c-fos and junB genes.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(17):6738-42.
1990: Sheila A Shurtleff; James R Downing; C O Rock; S A Hawkins; Martine F Roussel; Charles J Sherr
Structural features of the colony-stimulating factor 1 receptor that affect its association with phosphatidylinositol 3-kinase.
The EMBO journal 1990;9(8):2415-21.
1990: M Ohtsuka; Martine F Roussel; Charles J Sherr; James R Downing
Ligand-induced phosphorylation of the colony-stimulating factor 1 receptor can occur through an intermolecular reaction that triggers receptor down modulation.
Molecular and cellular biology 1990;10(4):1664-71.
1990: Charles J Sherr; J Y Kato; G Borzillo; James R Downing; Martine F Roussel
Signal-response coupling mediated by the transduced colony-stimulating factor-1 receptor and its oncogenic fms variants in naive cells.
Ciba Foundation symposium 1990;148():96-104; discussion 104-9.
1989: James R Downing; M F Roussel; C J Sherr
Ligand and protein kinase C downmodulate the colony-stimulating factor 1 receptor by independent mechanisms.
Molecular and cellular biology 1989;9(7):2890-6.
1988: Martine F Roussel; James R Downing; C W Rettenmier; Charles J Sherr
A point mutation in the extracellular domain of the human CSF-1 receptor (c-fms proto-oncogene product) activates its transforming potential.
Cell 1988;55(6):979-88.
1988: Martine F Roussel; James R Downing; RA Ashmun; C W Rettenmier; Charles J Sherr
Colony-stimulating factor 1-mediated regulation of a chimeric c-fms/v-fms receptor containing the v-fms-encoded tyrosine kinase domain.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(16):5903-7.
1988: J R Haynes; James R Downing
A recessive cellular mutation in v-fes-transformed mink cells restores contact inhibition and anchorage-dependent growth.
Molecular and cellular biology 1988;8(6):2419-27.
1988: James R Downing; C W Rettenmier; Charles J Sherr
Ligand-induced tyrosine kinase activity of the colony-stimulating factor 1 receptor in a murine macrophage cell line.
Molecular and cellular biology 1988;8(4):1795-9.