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Kenneth Downing

Research Profile

Procedures

Chemicals & Drugs

Concepts & Ideas

Anatomy

Microtubules

Living Beings

Activities & Behaviors

Image Processing, Computer-Assisted

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Publications

TOP 3
Puey Ounjai; Andrew N Tauscher; H Ewa Witkowska; Ming Dong; Keunhwan D Kim; Haichuan Liu; Kenneth H Downing
Architectural insights into a ciliary partition.
Birgit Luef; Michael J Wilkins; Kenneth H Williams; Kelly C Wrighton; Luis R Comolli; Roseann Csencsits; Kenneth H Downing; Sirine C Fakra; Philip E Long; Jillian F Banfield
Iron-reducing bacteria accumulate ferric oxyhydroxide nanoparticle aggregates that may support planktonic growth.
Sergey Yakovlev; Kenneth H Downing
Visualization of clusters in polymer electrolyte membranes by electron microscopy.

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All Publications

2013: Puey Ounjai; Andrew N Tauscher; H Ewa Witkowska; Ming Dong; Keunhwan D Kim; Haichuan Liu; Kenneth H Downing
Architectural insights into a ciliary partition.
Current biology : CB 2013;23(4):339-44.
2013: Birgit Luef; Michael J Wilkins; Kenneth H Williams; Kelly C Wrighton; Luis R Comolli; Roseann Csencsits; Kenneth H Downing; Sirine C Fakra; Philip E Long; Jillian F Banfield
Iron-reducing bacteria accumulate ferric oxyhydroxide nanoparticle aggregates that may support planktonic growth.
The ISME journal 2013;7(2):338-50.
2013: Sergey Yakovlev; Kenneth H Downing
Visualization of clusters in polymer electrolyte membranes by electron microscopy.
Physical chemistry chemical physics : PCCP 2013;15(4):1052-64.
2013: Kenneth H Downing
Future developments in instrumentation for electron crystallography.
Methods in molecular biology (Clifton, N.J.) 2013;955():353-79.
2012: Puey Ounjai; Keunhwan D Kim; Polina V Lishko; Kenneth H Downing
Three-dimensional structure of the bovine sperm connecting piece revealed by electron cryotomography.
Biology of reproduction 2012;87(3):73.
2012: Dorothée Murat; André Körnig; Luca Bertinetti; Roseann Csencsits; Kenneth H Downing; Damien Faivre; Veesta Falahati; Arash Komeili
The magnetosome membrane protein, MmsF, is a major regulator of magnetite biomineralization in Magnetospirillum magneticum AMB-1.
Molecular microbiology 2012;85(4):684-99.
2012: He Dong; Kenneth H Downing; Nikhil Dube; Yufei Ma; Jessica Y Shu; Matthew V Tirrell; Ting Xu
3-Helix micelles stabilized by polymer springs.
Journal of the American Chemical Society 2012;134(28):11807-14.
2012: Luis R Comolli; Roseann Csencsits; Kenneth H Downing; Robert Duarte; David M Larson; Birgit Luef; Dennis Baum; Jillian F Banfield
A portable cryo-plunger for on-site intact cryogenic microscopy sample preparation in natural environments.
Microscopy research and technique 2012;75(6):829-36.
2011: S Yakovlev; Kenneth H Downing
Crystalline ice as a cryoprotectant: theoretical calculation of cooling speed in capillary tubes.
Journal of microscopy 2011;243(1):8-14.
2011: David M Larson; Kenneth H Downing; Robert M Glaeser
The surface of evaporated carbon films is an insulating, high-bandgap material.
Journal of structural biology 2011;174(2):420-3.
2011: Huaibin Wang; Kenneth H Downing
Specimen preparation for electron diffraction of thin crystals.
Micron (Oxford, England : 1993) 2011;42(2):132-40.
2010: Fernando Amat; Luis R Comolli; John F Nomellini; Farshid Moussavi; Kenneth H Downing; John Smit; Mark Horowitz
Analysis of the intact surface layer of Caulobacter crescentus by cryo-electron tomography.
Journal of bacteriology 2010;192(22):5855-65.
2010: Yi-Chun Yeh; Luis R Comolli; Kenneth H Downing; Lucy Shapiro; Harley McAdams
The caulobacter Tol-Pal complex is essential for outer membrane integrity and the positioning of a polar localization factor.
Journal of bacteriology 2010;192(19):4847-58.
2010: Fernando Amat; Luis R Comolli; Farshid Moussavi; John Smit; Kenneth H Downing; Mark Horowitz
Subtomogram alignment by adaptive Fourier coefficient thresholding.
Journal of structural biology 2010;171(3):332-44.
2010: Haixin Sui; Kenneth H Downing
Structural basis of interprotofilament interaction and lateral deformation of microtubules.
Structure (London, England : 1993) 2010;18(8):1022-31.
2010: Meghan E Byrne; David A Ball; Jean-Luc Guerquin-Kern; Isabelle Rouiller; Ting-Di Wu; Kenneth H Downing; Hojatollah Vali; Arash Komeili
Desulfovibrio magneticus RS-1 contains an iron- and phosphorus-rich organelle distinct from its bullet-shaped magnetosomes.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(27):12263-8.
2010: Erin Goley; Luis R Comolli; Katherine E Fero; Kenneth H Downing; Lucy Shapiro
DipM links peptidoglycan remodelling to outer membrane organization in Caulobacter.
Molecular microbiology 2010;77(1):56-73.
2010: Grant R Bowman; Luis R Comolli; Guido M Gaietta; Michael Fero; Sun-Hae Hong; Ying Jones; Julie H Lee; Kenneth H Downing; Mark H Ellisman; Harley McAdams; Lucy Shapiro
Caulobacter PopZ forms a polar subdomain dictating sequential changes in pole composition and function.
Molecular microbiology 2010;76(1):173-89.
2010: Charles V Sindelar; Kenneth H Downing
An atomic-level mechanism for activation of the kinesin molecular motors.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(9):4111-6.
2010: Kenneth H Downing; Eva Nogales
Cryoelectron microscopy applications in the study of tubulin structure, microtubule architecture, dynamics and assemblies, and interaction of microtubules with motors.
Methods in enzymology 2010;483():121-42.
2009: Bong-Gyoon Han; Ming Dong; Haichuan Liu; Lauren Camp; Jil Geller; Mary Singer; Terry C Hazen; Megan Choi; H Ewa Witkowska; David A Ball; Dieter Typke; Kenneth H Downing; Maxim Shatsky; Steven E Brenner; John-Marc Chandonia; Mark D Biggin; Robert M Glaeser
Survey of large protein complexes in D. vulgaris reveals great structural diversity.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(39):16580-5.
2009: Hoi-Ying N Holman; Eleanor Wozei; Zhang Lin; Luis R Comolli; David A Ball; Sharon Borglin; matthew w fields; Terry C Hazen; Kenneth H Downing
Real-time molecular monitoring of chemical environment in obligate anaerobes during oxygen adaptive response.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(31):12599-604.
2009: Enrique D Gomez; Ashoutosh Panday; Edward H Feng; Vincent Chen; Gregory M Stone; Andrew M Minor; Christian Kisielowski; Kenneth H Downing; Oleg Borodin; Grant D Smith; Nitash P Balsara
Effect of ion distribution on conductivity of block copolymer electrolytes.
Nano letters 2009;9(3):1212-6.
2009: Luis R Comolli; Brett Baker; Kenneth H Downing; Cristina E Siegerist; Jillian F Banfield
Three-dimensional analysis of the structure and ecology of a novel, ultra-small archaeon.
The ISME journal 2009;3(2):159-67.
2008: Grant R Bowman; Luis R Comolli; Jian Zhu; Michael Eckart; Marcelle Koenig; Kenneth H Downing; WE Moerner; Thomas Earnest; Lucy Shapiro
A polymeric protein anchors the chromosomal origin/ParB complex at a bacterial cell pole.
Cell 2008;134(6):945-55.
2008: Kenneth H Downing; Robert M Glaeser
Restoration of weak phase-contrast images recorded with a high degree of defocus: the "twin image" problem associated with CTF correction.
Ultramicroscopy 2008;108(9):921-8.
2008: Kenneth H Downing; Paul E Mooney
A charge coupled device camera with electron decelerator for intermediate voltage electron microscopy.
The Review of scientific instruments 2008;79(4):043702.
2008: Fernando Amat; Farshid Moussavi; Luis R Comolli; Gal Elidan; Kenneth H Downing; Mark Horowitz
Markov random field based automatic image alignment for electron tomography.
Journal of structural biology 2008;161(3):260-75.
2008: Luis R Comolli; Andrew J Spakowitz; Cristina E Siegerist; Paul J Jardine; Shelley Grimes; Dwight L Anderson; Carlos Bustamante; Kenneth H Downing
Three-dimensional architecture of the bacteriophage phi29 packaged genome and elucidation of its packaging process.
Virology 2008;371(2):267-77.
2007: Alison N Killilea; Kenneth H Downing; David W Killilea
Zinc deficiency reduces paclitaxel efficacy in LNCaP prostate cancer cells.
Cancer letters 2007;258(1):70-9.
2007: Kenneth H Downing; Haixin Sui; Manfred Auer
Electron tomography: a 3D view of the subcellular world.
Analytical chemistry 2007;79(21):7949-57.
2007: Moon Jeong Park; Kenneth H Downing; Andrew Jackson; Enrique D Gomez; Andrew M Minor; David Cookson; Adam Z Weber; Nitash P Balsara
Increased water retention in polymer electrolyte membranes at elevated temperatures assisted by capillary condensation.
Nano letters 2007;7(11):3547-52.
2007: Charles V Sindelar; Kenneth H Downing
The beginning of kinesin's force-generating cycle visualized at 9-A resolution.
The Journal of cell biology 2007;177(3):377-85.
2007: Kenneth H Downing; Haixin Sui
Structural insights into microtubule doublet interactions in axonemes.
Current opinion in structural biology 2007;17(2):253-9.
2007: Rossana Cambie; Kenneth H Downing; Dieter Typke; Robert M Glaeser; Jian Jin
Design of a microfabricated, two-electrode phase-contrast element suitable for electron microscopy.
Ultramicroscopy 2007;107(4-5):329-39.
2007: Dieter Typke; Christopher J Gilpin; Kenneth H Downing; Robert M Glaeser
Stroboscopic image capture: reducing the dose per frame by a factor of 30 does not prevent beam-induced specimen movement in paraffin.
Ultramicroscopy 2007;107(2-3):106-15.
2006: Haixin Sui; Kenneth H Downing
Molecular architecture of axonemal microtubule doublets revealed by cryo-electron tomography.
Nature 2006;442(7101):475-8.
2006: Luis R Comolli; M Kundmann; Kenneth H Downing
Characterization of intact subcellular bodies in whole bacteria by cryo-electron tomography and spectroscopic imaging.
Journal of microscopy 2006;223(Pt 1):40-52.
2006: Oren S Rosenberg; Sebastian Deindl; Luis R Comolli; André Hoelz; Kenneth H Downing; Angus Nairn; John Kuriyan
Oligomerization states of the association domain and the holoenyzme of Ca2+/CaM kinase II.
The FEBS journal 2006;273(4):682-94.
2005: Luis R Comolli; Kenneth H Downing
Dose tolerance at helium and nitrogen temperatures for whole cell electron tomography.
Journal of structural biology 2005;152(3):149-56.
2005: Ellen M Judd; Luis R Comolli; Joseph C Chen; Kenneth H Downing; WE Moerner; Harley McAdams
Distinct constrictive processes, separated in time and space, divide caulobacter inner and outer membranes.
Journal of bacteriology 2005;187(20):6874-82.
2005: Dieter Typke; Robert A Nordmeyer; Arthur Jones; Juyoung Lee; Agustin Avila-Sakar; Kenneth H Downing; Robert M Glaeser
High-throughput film-densitometry: an efficient approach to generate large data sets.
Journal of structural biology 2005;149(1):17-29.
2004: Robert M Glaeser; Kenneth H Downing
Specimen charging on thin films with one conducting layer: discussion of physical principles.
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2004;10(6):790-6.
2004: Kenneth H Downing; M R McCartney; Robert M Glaeser
Experimental characterization and mitigation of specimen charging on thin films with one conducting layer.
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2004;10(6):783-9.
2004: Janet L Paluh; Alison N Killilea; H William Detrich; Kenneth H Downing
Meiosis-specific failure of cell cycle progression in fission yeast by mutation of a conserved beta-tubulin residue.
Molecular biology of the cell 2004;15(3):1160-71.
2004: Dieter Typke; Kenneth H Downing; Robert M Glaeser
Electron microscopy of biological macromolecules: bridging the gap between what physics allows and what we currently can get.
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2004;10(1):21-7.
2003: J C H Spence; Uwe Weierstall; T T Fricke; Robert M Glaeser; Kenneth H Downing
Three-dimensional diffractive imaging for crystalline monolayers with one-dimensional compact support.
Journal of structural biology 2003;144(1-2):209-18.
2002: Huilin Li; David J DeRosier; William V Nicholson; Eva Nogales; Kenneth H Downing
Microtubule structure at 8 A resolution.
Structure (London, England : 1993) 2002;10(10):1317-28.
2002: Shijun Zhong; Voichita M Dadarlat; Robert M Glaeser; Teresa Head-Gordon; Kenneth H Downing
Modeling chemical bonding effects for protein electron crystallography: the transferable fragmental electrostatic potential (TFESP) method.
Acta crystallographica. Section A, Foundations of crystallography 2002;58(Pt 2):162-70.
2001: Agustin Avila-Sakar; S Misaghi; E M Wilson-Kubalek; Kenneth H Downing; Helen I Zgurskaya; Hiroshi Nikaido; Eva Nogales
Lipid-layer crystallization and preliminary three-dimensional structural analysis of AcrA, the periplasmic component of a bacterial multidrug efflux pump.
Journal of structural biology 2001;136(1):81-8.
2000: Kristy Richards; K R Anders; Eva Nogales; K Schwartz; Kenneth H Downing; David Botstein
Structure-function relationships in yeast tubulins.
Molecular biology of the cell 2000;11(5):1887-903.
2000: Kenneth H Downing
Structural basis for the interaction of tubulin with proteins and drugs that affect microtubule dynamics.
Annual review of cell and developmental biology 2000;16():89-111.
1999: Y Han; Elena P Sablin; Eva Nogales; Robert J Fletterick; Kenneth H Downing
Visualizing a new binding site of ncd-motor domain on tubulin.
Journal of structural biology 1999;128(1):26-33.
1999: Kenneth H Downing; Eva Nogales
Crystallographic structure of tubulin: implications for dynamics and drug binding.
Cell structure and function 1999;24(5):269-75.
1999: S Chang; Teresa Head-Gordon; Robert M Glaeser; Kenneth H Downing
Chemical bonding effects in the determination of protein structures by electron crystallography.
Acta crystallographica. Section A, Foundations of crystallography 1999;55 ( Pt 2 Pt 2)():305-13.
1999: Becket Feierbach; Eva Nogales; Kenneth H Downing; Tim Stearns
Alf1p, a CLIP-170 domain-containing protein, is functionally and physically associated with alpha-tubulin.
The Journal of cell biology 1999;144(1):113-24.
1999: William V Nicholson; M Lee; Kenneth H Downing; Eva Nogales
Cryo-electron microscopy of GDP-tubulin rings.
Cell biochemistry and biophysics 1999;31(2):175-83.
1999: Kenneth H Downing; F M Hendrickson
Performance of a 2k CCD camera designed for electron crystallography at 400 kV.
Ultramicroscopy 1999;75(4):215-33.
1998: Kenneth H Downing; Eva Nogales
Tubulin structure: insights into microtubule properties and functions.
Current opinion in structural biology 1998;8(6):785-91.
1998: Eva Nogales; Sharon Wolf; Kenneth H Downing
Structure of the alpha beta tubulin dimer by electron crystallography.
Nature 1998;391(6663):199-203.
1998: Kenneth H Downing; Eva Nogales
New insights into microtubule structure and function from the atomic model of tubulin.
European biophysics journal : EBJ 1998;27(5):431-6.
1997: Eva Nogales; Sharon Wolf; Kenneth H Downing
Visualizing the secondary structure of tubulin: three-dimensional map at 4 A.
Journal of structural biology 1997;118(2):119-27.
1996: Sharon Wolf; Eva Nogales; M Kikkawa; dita gratzinger; N Hirokawa; Kenneth H Downing
Interpreting a medium-resolution model of tubulin: comparison of zinc-sheet and microtubule structure.
Journal of molecular biology 1996;262(4):485-501.
1995: B F McEwen; Kenneth H Downing; Robert M Glaeser
The relevance of dose-fractionation in tomography of radiation-sensitive specimens.
Ultramicroscopy 1995;60(3):357-73.
1995: Eva Nogales; Sharon Wolf; S X Zhang; Kenneth H Downing
Preservation of 2-D crystals of tubulin for electron crystallography.
Journal of structural biology 1995;115(2):199-208.
1995: Guy Perkins; Kenneth H Downing; Robert M Glaeser
Crystallographic extraction and averaging of data from small image areas.
Ultramicroscopy 1995;60(2):283-94.
1995: Eva Nogales; Sharon Wolf; I A Khan; Richard Luduena; Kenneth H Downing
Structure of tubulin at 6.5 A and location of the taxol-binding site.
Nature 1995;375(6530):424-7.
1995: S Ray; Sharon Wolf; Jonathon Howard; Kenneth H Downing
Kinesin does not support the motility of zinc-macrotubes.
Cell motility and the cytoskeleton 1995;30(2):146-52.
1993: Robert M Glaeser; Kenneth H Downing
High-resolution electron crystallography of protein molecules.
Ultramicroscopy 1993;52(3-4):478-86.
1993: Sharon Wolf; G Mosser; Kenneth H Downing
Tubulin conformation in zinc-induced sheets and macrotubes.
Journal of structural biology 1993;111(3):190-9.
1992: Robert M Glaeser; Kenneth H Downing
Assessment of resolution in biological electron crystallography.
Ultramicroscopy 1992;47(1-3):256-65.
1992: Kenneth H Downing
Automatic focus correction for spot-scan imaging of tilted specimens.
Ultramicroscopy 1992;46(1-4):199-206.
1992: Kenneth H Downing; J Jontes
Projection map of tubulin in zinc-induced sheets at 4 A resolution.
Journal of structural biology 1992;109(2):152-9.
1992: Kenneth H Downing
Three-dimensional crystallographic reconstruction for atomic resolution.
Scanning microscopy. Supplement 1992;6():43-52.
1991: S S Sikerwar; Kenneth H Downing; Robert M Glaeser
Three-dimensional structure of an invertebrate intercellular communicating junction.
Journal of structural biology 1991;106(3):255-63.
1991: Robert M Glaeser; Kenneth H Downing; Bing K Jap
What spectroscopy can still tell us about the secondary structure of bacteriorhodopsin.
Biophysical journal 1991;59(4):934-8.
1991: Kenneth H Downing
Spot-scan imaging in transmission electron microscopy.
Science (New York, N.Y.) 1991;251(4989):53-9.
1990: Bing K Jap; Kenneth H Downing; Peter J Walian
Structure of PhoE porin in projection at 3.5 A resolution.
Journal of structural biology 1990;103(1):57-63.
1988: Kenneth H Downing
Observations of restricted beam-induced specimen motion with small-spot illumination.
Ultramicroscopy 1988;24(4):387-97.
1986: M R Dickson; Kenneth H Downing; W H Wu; Robert M Glaeser
Three-dimensional structure of the surface layer protein of Aquaspirillum serpens VHA determined by electron crystallography.
Journal of bacteriology 1986;167(3):1025-34.
1986: Kenneth H Downing; Robert M Glaeser
Improvement in high resolution image quality of radiation-sensitive specimens achieved with reduced spot size of the electron beam.
Ultramicroscopy 1986;20(3):269-78.
1983: C F Chang; R C Williams; D A Grano; Kenneth H Downing; Robert M Glaeser
Quantitative evaluation of high-resolution features in images of negatively stained Tobacco Mosaic Virus.
Ultramicroscopy 1983;11(1):3-11.
1980: Kenneth H Downing; Robert M Glaeser
Electron diffraction from single crystals of DNA.
Biophysical journal 1980;32(2):851-6.