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Julian Downward
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11
Buday, László
10
Cantrell, Doreen
10
Warne, PH
9
Rodriguez-Viciana, P
7
Waterfield, Michael
7
Pardo, Olivier
7
Nicke, Barbara
6
Martins, Miguel
6
Hallberg, Bengt
6
Warne, Patricia
5
Michl, Patrick
5
Lemoine, Nicholas
5
Arcaro, Alexandre
4
Beug, Hartmut
4
Faragó, Anna
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All Publications
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2009: Downward Julian
Cancer: A tumour gene's fatal flaws.
Nature 2009;462(7269):44-5.
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2009: Ding Xiaoyan; Patel Mrinali; Shen Defen; Herzlich Alexandra A; Cao Xiaoguang; Villasmil Rafael; Klupsch Kristina; Tuo Jingsheng; Downward Julian; Chan Chi-Chao
Enhanced HtrA2/Omi expression in oxidative injury to retinal pigment epithelial cells and murine models of neurodegeneration.
Investigative ophthalmology & visual science 2009;50(10):4957-66.
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2009: Downward Julian
Finding the weakness in cancer.
The New England journal of medicine 2009;361(9):922-4.
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2009: Liu Meng-Lu; Liu Ming-Jie; Shen Yan-Fei; Ryu Hoon; Kim Hyeon-Jin; Klupsch Kristina; Downward Julian; Hong Seong-Tshool
Omi is a mammalian heat-shock protein that selectively binds and detoxifies oligomeric amyloid-beta.
Journal of cell science 2009;122(Pt 11):1917-26.
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2009: Swanton Charles; Nicke Barbara; Schuett Marion; Eklund Aron C; Ng Charlotte; Li Qiyuan; Hardcastle Thomas; Lee Alvin; Roy Rajat; East Philip; Kschischo Maik; Endesfelder David; Wylie Paul; Kim Se Nyun; Chen Jie-Guang; Howell Michael; Ried Thomas; Habermann Jens K; Auer Gert; Brenton James D; Szallasi Zoltan; Downward Julian
Chromosomal instability determines taxane response.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(21):8671-6.
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2009: Gandhi Sonia; Wood-Kaczmar Alison; Yao Zhi; Plun-Favreau Helene; Deas Emma; Klupsch Kristina; Downward Julian; Latchman David S; Tabrizi Sarah J; Wood Nicholas W; Duchen Michael R; Abramov Andrey Y
PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death.
Molecular cell 2009;33(5):627-38.
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2009: Downward Julian; Hahn William C
Genetic and cellular mechanisms of oncogenesis.
Current opinion in genetics & development 2009;19(1):1-3.
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2009: Cully Megan; Downward Julian
Translational responses to growth factors and stress.
Biochemical Society transactions 2009;37(Pt 1):284-8.
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2008: Downward Julian; Basu Subham
YAP and p73: a complex affair.
Molecular cell 2008;32(6):749-50.
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2008: Lee Alvin J X; East Phillip; Pepper Stuart; Nicke Barbara; Szallasi Zoltan; Eklund Aron C; Downward Julian; Swanton Charles
Concordance of exon array and real-time PCR assessment of gene expression following cancer cell cytotoxic drug exposure.
Cell cycle (Georgetown, Tex.) 2008;7(24):3947-8.
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2008: Downward Julian
Targeting RAS and PI3K in lung cancer.
Nature medicine 2008;14(12):1315-6.
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2008: Buday László; Downward Julian
Many faces of Ras activation.
Biochimica et biophysica acta 2008;1786(2):178-87.
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2008: Kawamoto Yasuhiro; Kobayashi Yoshito; Suzuki Yasuyuki; Inoue Haruhisa; Tomimoto Hidekazu; Akiguchi Ichiro; Budka Herbert; Martins L Miguel; Downward Julian; Takahashi Ryosuke
Accumulation of HtrA2/Omi in neuronal and glial inclusions in brains with alpha-synucleinopathies.
Journal of neuropathology and experimental neurology 2008;67(10):984-93.
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2008: Cully Megan; Downward Julian
SnapShot: Ras Signaling.
Cell 2008;133(7):1292-1292.e1.
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2008: Swanton Charles; Downward Julian
Unraveling the complexity of endocrine resistance in breast cancer by functional genomics.
Cancer cell 2008;13(2):83-5.
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2008: Swanton Charles; Szallasi Zoltan; Brenton James D; Downward Julian
Functional genomic analysis of drug sensitivity pathways to guide adjuvant strategies in breast cancer.
Breast cancer research : BCR 2008;10(5):214.
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2008: Wood-Kaczmar Alison; Gandhi Sonia; Yao Zhi; Abramov Andrey Y; Miljan Erik A; Keen Gregory; Stanyer Lee; Hargreaves Iain; Klupsch Kristina; Deas Emma; Downward Julian; Mansfield Louise; Jat Parmjit; Taylor Joanne; Heales Simon; Duchen Michael R; Latchman David; Tabrizi Sarah J; Wood Nicholas W
PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons.
PloS one 2008;3(6):e2455.
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2007: Ahmed Ahmed Ashour; Mills Anthony D; Ibrahim Ashraf E K; Temple Jillian; Blenkiron Cherie; Vias Maria; Massie Charlie E; Iyer N Gopalakrishna; McGeoch Adam; Crawford Robin; Nicke Barbara; Downward Julian; Swanton Charles; Bell Stephen D; Earl Helena M; Laskey Ronald A; Caldas Carlos; Brenton James D
The extracellular matrix protein TGFBI induces microtubule stabilization and sensitizes ovarian cancers to paclitaxel.
Cancer cell 2007;12(6):514-27.
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2007: Ramjaun Antoine R; Downward Julian
Ras and phosphoinositide 3-kinase: partners in development and tumorigenesis.
Cell cycle (Georgetown, Tex.) 2007;6(23):2902-5.
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2007: Plun-Favreau Hélène; Klupsch Kristina; Moisoi Nicoleta; Gandhi Sonia; Kjaer Svend; Frith David; Harvey Kirsten; Deas Emma; Harvey Robert J; McDonald Neil; Wood Nicholas W; Martins L Miguel; Downward Julian
The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1.
Nature cell biology 2007;9(11):1243-52.
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2007: Swanton Charles; Nicke Barbara; Marani Michela; Kelly Gavin; Downward Julian
Initiation of high frequency multi-drug resistance following kinase targeting by siRNAs.
Cell cycle (Georgetown, Tex.) 2007;6(16):2001-4.
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2007: Delpuech Oona; Griffiths Beatrice; East Philip; Essafi Abdelkader; Lam Eric W-F; Burgering Boudewijn; Downward Julian; Schulze Almut
Induction of Mxi1-SR alpha by FOXO3a contributes to repression of Myc-dependent gene expression.
Molecular and cellular biology 2007;27(13):4917-30.
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2007: Swanton Charles; Marani Michela; Pardo Olivier; Warne Patricia H; Kelly Gavin; Sahai Erik; Elustondo Frédéric; Chang Jenny; Temple Jillian; Ahmed Ahmed A; Brenton James D; Downward Julian; Nicke Barbara
Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs.
Cancer cell 2007;11(6):498-512.
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2007: Gupta Surbhi; Ramjaun Antoine R; Haiko Paula; Wang Yihua; Warne Patricia H; Nicke Barbara; Nye Emma; Stamp Gordon; Alitalo Kari; Downward Julian
Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice.
Cell 2007;129(5):957-68.
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2007: Buday László; Downward Julian
Roles of cortactin in tumor pathogenesis.
Biochimica et biophysica acta 2007;1775(2):263-73.
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2007: Ripka S; König A; Buchholz M; Wagner M; Sipos B; Klöppel G; Downward J; Gress Tm; Michl P
WNT5A--target of CUTL1 and potent modulator of tumor cell migration and invasion in pancreatic cancer.
Carcinogenesis 2007;28(6):1178-87.
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2007: Calleja Véronique; Alcor Damien; Laguerre Michel; Park Jongsun; Vojnovic Borivoj; Hemmings Brian A; Downward Julian; Parker Peter J; Larijani Banafshé
Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo.
PLoS biology 2007;5(4):e95.
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2006: Janda E; Nevolo M; Lehmann K; Downward J; Beug H; Grieco M
Raf plus TGFbeta-dependent EMT is initiated by endocytosis and lysosomal degradation of E-cadherin.
Oncogene 2006;25(54):7117-30.
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2006: Downward Julian
Signal transduction. Prelude to an anniversary for the RAS oncogene.
Science (New York, N.Y.) 2006;314(5798):433-4.
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2006: Echeverri Christophe J; Beachy Philip A; Baum Buzz; Boutros Michael; Buchholz Frank; Chanda Sumit K; Downward Julian; Ellenberg Jan; Fraser Andrew G; Hacohen Nir; Hahn William C; Jackson Aimee L; Kiger Amy; Linsley Peter S; Lum Lawrence; Ma Yong; Mathey-Prévôt Bernard; Root David E; Sabatini David M; Taipale Jussi; Perrimon Norbert; Bernards René
Minimizing the risk of reporting false positives in large-scale RNAi screens.
Nature methods 2006;3(10):777-9.
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2006: Postigo A; Cross J R; Downward J; Way M
Interaction of F1L with the BH3 domain of Bak is responsible for inhibiting vaccinia-induced apoptosis.
Cell death and differentiation 2006;13(10):1651-62.
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2006: Katso Roy M; Pardo Olivier E; Palamidessi Andrea; Franz Clemens M; Marinov Marin; De Laurentiis Angela; Downward Julian; Scita Giorgio; Ridley Anne J; Waterfield Michael D; Arcaro Alexandre
Phosphoinositide 3-Kinase C2beta regulates cytoskeletal organization and cell migration via Rac-dependent mechanisms.
Molecular biology of the cell 2006;17(9):3729-44.
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2006: Pardo Olivier E; Wellbrock Claudia; Khanzada Umme K; Aubert Muriel; Arozarena Imanol; Davidson Sally; Bowen Frances; Parker Peter J; Filonenko V V; Gout Ivan T; Sebire Neil; Marais Richard; Downward Julian; Seckl Michael J
FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCepsilon, B-Raf and S6K2.
The EMBO journal 2006;25(13):3078-88.
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2006: Michl Patrick; Knobel Beate; Downward Julian
CUTL1 is phosphorylated by protein kinase A, modulating its effects on cell proliferation and motility.
The Journal of biological chemistry 2006;281(22):15138-44.
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2006: Jansson Anna L; Yasmin Lubna; Warne Patricia; Downward Julian; Palmer Ruth H; Hallberg Bengt
Exoenzyme S of Pseudomonas aeruginosa is not able to induce apoptosis when cells express activated proteins, such as Ras or protein kinase B/Akt.
Cellular microbiology 2006;8(5):815-22.
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2006: Swanton Charles; Tomlinson Ian; Downward Julian
Chromosomal instability, colorectal cancer and taxane resistance.
Cell cycle (Georgetown, Tex.) 2006;5(8):818-23.
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2006: Shin Soon Young; Bahk Young Yil; Ko Jesang; Chung Il-Yup; Lee Young Seek; Downward Julian; Eibel Hermann; Sharma Prem M; Olefsky Jerrold M; Kim Young-Ho; Lee Bonghee; Lee Young Han
Suppression of Egr-1 transcription through targeting of the serum response factor by oncogenic H-Ras.
The EMBO journal 2006;25(5):1093-103.
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2006: Khanzada U K; Pardo O E; Meier C; Downward J; Seckl M J; Arcaro A
Potent inhibition of small-cell lung cancer cell growth by simvastatin reveals selective functions of Ras isoforms in growth factor signalling.
Oncogene 2006;25(6):877-87.
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2006: Downward Julian
Cancer biology: signatures guide drug choice.
Nature 2006;439(7074):274-5.
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2006: Michl Patrick; Downward Julian
CUTL1: a key mediator of TGFbeta-induced tumor invasion.
Cell cycle (Georgetown, Tex.) 2006;5(2):132-4.
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2005: Nicke Barbara; Bastien Julie; Khanna Sophia J; Warne Patricia H; Cowling Victoria; Cook Simon J; Peters Gordon; Delpuech Oona; Schulze Almut; Berns Katrien; Mullenders Jasper; Beijersbergen Roderick L; Bernards René; Ganesan Trivadi S; Downward Julian; Hancock David C
Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells.
Molecular cell 2005;20(5):673-85.
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2005: Michl P; Downward J
Mechanisms of disease: PI3K/AKT signaling in gastrointestinal cancers.
Zeitschrift für Gastroenterologie 2005;43(10):1133-9.
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2005: Porstmann Thomas; Griffiths Beatrice; Chung Yuen-Li; Delpuech Oona; Griffiths John R; Downward Julian; Schulze Almut
PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP.
Oncogene 2005;24(43):6465-81.
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2005: Strauss Karsten M; Martins L Miguel; Plun-Favreau Helene; Marx Frank P; Kautzmann Sabine; Berg Daniela; Gasser Thomas; Wszolek Zbginiew; Müller Thomas; Bornemann Antje; Wolburg Hartwig; Downward Julian; Riess Olaf; Schulz Jörg B; Krüger Rejko
Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease.
Human molecular genetics 2005;14(15):2099-111.
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2005: Downward Julian
RNA interference libraries prove their worth in hunt for tumor suppressor genes.
Cell 2005;121(6):813-5.
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2005: Michl Patrick; Ramjaun Antoine R; Pardo Olivier E; Warne Patricia H; Wagner Martin; Poulsom Richard; D'Arrigo Corrado; Ryder Kenneth; Menke Andre; Gress Thomas; Downward Julian
CUTL1 is a target of TGF(beta) signaling that enhances cancer cell motility and invasiveness.
Cancer cell 2005;7(6):521-32.
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2005: Baksh Shairaz; Tommasi Stella; Fenton Sarah; Yu Victor C; Martins L Miguel; Pfeifer Gerd P; Latif Farida; Downward Julian; Neel Benjamin G
The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death.
Molecular cell 2005;18(6):637-50.
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2004: Swanton Charles; Nicke Barbara; Downward Julian
RNA interference, DNA methylation, and gene silencing: a bright future for cancer therapy?
The lancet oncology 2004;5(11):653-4.
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2004: Downward Julian
Use of RNA interference libraries to investigate oncogenic signalling in mammalian cells.
Oncogene 2004;23(51):8376-83.
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2004: Downward Julian
RNA interference-based functional genomics in cancer research--an introduction.
Oncogene 2004;23(51):8334-5.
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2004: Martins L Miguel; Morrison Alastair; Klupsch Kristina; Fedele Valentina; Moisoi Nicoleta; Teismann Peter; Abuin Alejandro; Grau Evelyn; Geppert Martin; Livi George P; Creasy Caretha L; Martin Alison; Hargreaves Iain; Heales Simon J; Okada Hitoshi; Brandner Sebastian; Schulz Jörg B; Mak Tak; Downward Julian
Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice.
Molecular and cellular biology 2004;24(22):9848-62.
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2004: Schulze Almut; Nicke Barbara; Warne Patricia H; Tomlinson Simon; Downward Julian
The transcriptional response to Raf activation is almost completely dependent on Mitogen-activated Protein Kinase Kinase activity and shows a major autocrine component.
Molecular biology of the cell 2004;15(7):3450-63.
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2004: Dallol Ashraf; Agathanggelou Angelo; Fenton Sarah L; Ahmed-Choudhury Jalal; Hesson Luke; Vos Michele D; Clark Geoffrey J; Downward Julian; Maher Eamonn R; Latif Farida
RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics.
Cancer research 2004;64(12):4112-6.
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2004: Downward Julian
RNA interference.
BMJ (Clinical research ed.) 2004;328(7450):1245-8.
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2004: Downward Julian
PI 3-kinase, Akt and cell survival.
Seminars in cell & developmental biology 2004;15(2):177-82.
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2004: Marani Michela; Hancock David; Lopes Rita; Tenev Tencho; Downward Julian; Lemoine Nicholas R
Role of Bim in the survival pathway induced by Raf in epithelial cells.
Oncogene 2004;23(14):2431-41.
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2004: Fenton Sarah L; Dallol Ashraf; Agathanggelou Angelo; Hesson Luke; Ahmed-Choudhury Jalal; Baksh Shairaz; Sardet Claude; Dammann Reinhard; Minna John D; Downward Julian; Maher Eamonn R; Latif Farida
Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene.
Cancer research 2004;64(1):102-7.
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2003: Downward Julian
Role of receptor tyrosine kinases in G-protein-coupled receptor regulation of Ras: transactivation or parallel pathways?
The Biochemical journal 2003;376(Pt 3):e9-10.
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2003: Martins L Miguel; Turk Benjamin E; Cowling Victoria; Borg Annabel; Jarrell Emily T; Cantley Lewis C; Downward Julian
Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi.
The Journal of biological chemistry 2003;278(49):49417-27.
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2003: Pardo Olivier E; Lesay Adeline; Arcaro Alexandre; Lopes Rita; Ng Bee Ling; Warne Patricia H; McNeish Iain A; Tetley Teresa D; Lemoine Nicholas R; Mehmet Huseyin; Seckl Michael J; Downward Julian
Fibroblast growth factor 2-mediated translational control of IAPs blocks mitochondrial release of Smac/DIABLO and apoptosis in small cell lung cancer cells.
Molecular and cellular biology 2003;23(21):7600-10.
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2003: Agathanggelou Angelo; Bièche Ivan; Ahmed-Choudhury Jalal; Nicke Barbara; Dammann Reinhard; Baksh Shairaz; Gao Boning; Minna John D; Downward Julian; Maher Eamonn R; Latif Farida
Identification of novel gene expression targets for the Ras association domain family 1 (RASSF1A) tumor suppressor gene in non-small cell lung cancer and neuroblastoma.
Cancer research 2003;63(17):5344-51.
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2003: Downward Julian
Cell biology: metabolism meets death.
Nature 2003;424(6951):896-7.
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2003: Iaccarino I; Hancock D; Evan G; Downward J
c-Myc induces cytochrome c release in Rat1 fibroblasts by increasing outer mitochondrial membrane permeability in a Bid-dependent manner.
Cell death and differentiation 2003;10(5):599-608.
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2003: Calleja Véronique; Ameer-Beg Simon M; Vojnovic Borivoj; Woscholski Rudiger; Downward Julian; Larijani Banafshé
Monitoring conformational changes of proteins in cells by fluorescence lifetime imaging microscopy.
The Biochemical journal 2003;372(Pt 1):33-40.
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2003: Tamás Péter; Solti Zita; Bauer Petra; Illés András; Sipeki Szabolcs; Bauer András; Faragó Anna; Downward Julian; Buday László
Mechanism of epidermal growth factor regulation of Vav2, a guanine nucleotide exchange factor for Rac.
The Journal of biological chemistry 2003;278(7):5163-71.
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2003: Basu Subham; Totty Nicholas F; Irwin Meredith S; Sudol Marius; Downward Julian
Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis.
Molecular cell 2003;11(1):11-23.
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2003: Downward Julian
Targeting RAS signalling pathways in cancer therapy.
Nature reviews. Cancer 2003;3(1):11-22.
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2003: Nicolás Francisco J; Lehmann Kerstin; Warne Patricia H; Hill Caroline S; Downward Julian
Epithelial to mesenchymal transition in Madin-Darby canine kidney cells is accompanied by down-regulation of Smad3 expression, leading to resistance to transforming growth factor-beta-induced growth arrest.
The Journal of biological chemistry 2003;278(5):3251-6.
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2002: Vyas Sheela; Béchade Catherine; Riveau Béatrice; Downward Julian; Triller Antoine
Involvement of survival motor neuron (SMN) protein in cell death.
Human molecular genetics 2002;11(22):2751-64.
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2002: Janda Elzbieta; Litos Gabi; Grünert Stefan; Downward Julian; Beug Hartmut
Oncogenic Ras/Her-2 mediate hyperproliferation of polarized epithelial cells in 3D cultures and rapid tumor growth via the PI3K pathway.
Oncogene 2002;21(33):5148-59.
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2002: Edme Natacha; Downward Julian; Thiery Jean-Paul; Boyer Brigitte
Ras induces NBT-II epithelial cell scattering through the coordinate activities of Rac and MAPK pathways.
Journal of cell science 2002;115(Pt 12):2591-601.
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2002: Marani Michela; Tenev Tencho; Hancock David; Downward Julian; Lemoine Nicholas R
Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis.
Molecular and cellular biology 2002;22(11):3577-89.
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2002: Reynolds Lucinda F; Smyth Lesley A; Norton Trisha; Freshney Norman; Downward Julian; Kioussis Dimitris; Tybulewicz Victor L J
Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways.
The Journal of experimental medicine 2002;195(9):1103-14.
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2002: Pardo Olivier E; Arcaro Alexandre; Salerno Giovanni; Raguz Selina; Downward Julian; Seckl Michael J
Fibroblast growth factor-2 induces translational regulation of Bcl-XL and Bcl-2 via a MEK-dependent pathway: correlation with resistance to etoposide-induced apoptosis.
The Journal of biological chemistry 2002;277(14):12040-6.
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2002: Inabe Kazunori; Ishiai Masamichi; Scharenberg Andrew M; Freshney Norman; Downward Julian; Kurosaki Tomohiro
Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation.
The Journal of experimental medicine 2002;195(2):189-200.
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2002: Janda Elzbieta; Lehmann Kerstin; Killisch Iris; Jechlinger Martin; Herzig Michaela; Downward Julian; Beug Hartmut; Grünert Stefan
Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways.
The Journal of cell biology 2002;156(2):299-313.
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2002: Martins L Miguel; Iaccarino Ingram; Tenev Tencho; Gschmeissner Stephen; Totty Nicholas F; Lemoine Nicholas R; Savopoulos John; Gray Carol W; Creasy Caretha L; Dingwall Colin; Downward Julian
The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif.
The Journal of biological chemistry 2002;277(1):439-44.
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2000: Zhao J; Tenev T; Martins L M; Downward J; Lemoine N R
The ubiquitin-proteasome pathway regulates survivin degradation in a cell cycle-dependent manner.
Journal of cell science 2000;113 Pt 23():4363-71.
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2000: Lehmann K; Janda E; Pierreux C E; Rytömaa M; Schulze A; McMahon M; Hill C S; Beug H; Downward J
Raf induces TGFbeta production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells.
Genes & development 2000;14(20):2610-22.
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1999: Altiok S; Batt D; Altiok N; Papautsky A; Downward J; Roberts T M; Avraham H
Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase/AKT in breast cancer cells.
The Journal of biological chemistry 1999;274(45):32274-8.
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1999: Ashcroft M; Stephens R M; Hallberg B; Downward J; Kaplan D R
The selective and inducible activation of endogenous PI 3-kinase in PC12 cells results in efficient NGF-mediated survival but defective neurite outgrowth.
Oncogene 1999;18(32):4586-97.
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1999: Gille H; Downward J
Multiple ras effector pathways contribute to G(1) cell cycle progression.
The Journal of biological chemistry 1999;274(31):22033-40.
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1999: Wennström S; Downward J
Role of phosphoinositide 3-kinase in activation of ras and mitogen-activated protein kinase by epidermal growth factor.
Molecular and cellular biology 1999;19(6):4279-88.
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1999: Wunderlich L; Gohér A; Faragó A; Downward J; Buday L
Requirement of multiple SH3 domains of Nck for ligand binding.
Cellular signalling 1999;11(4):253-62.
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1999: Wunderlich L; Faragó A; Downward J; Buday L
Association of Nck with tyrosine-phosphorylated SLP-76 in activated T lymphocytes.
European journal of immunology 1999;29(4):1068-75.
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1999: Watton S J; Downward J
Akt/PKB localisation and 3' phosphoinositide generation at sites of epithelial cell-matrix and cell-cell interaction.
Current biology : CB 1999;9(8):433-6.
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1998: Arcaro A; Volinia S; Zvelebil M J; Stein R; Watton S J; Layton M J; Gout I; Ahmadi K; Downward J; Waterfield M D
Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity.
The Journal of biological chemistry 1998;273(49):33082-90.
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1998: Fuller S J; Finn S G; Downward J; Sugden P H
Stimulation of gene expression in neonatal rat ventricular myocytes by Ras is mediated by Ral guanine nucleotide dissociation stimulator (Ral.GDS) and phosphatidylinositol 3-kinase in addition to Raf.
The Biochemical journal 1998;335 ( Pt 2)():241-6.
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1998: Hallberg B; Ashcroft M; Loeb D M; Kaplan D R; Downward J
Nerve growth factor induced stimulation of Ras requires Trk interaction with Shc but does not involve phosphoinositide 3-OH kinase.
Oncogene 1998;17(6):691-7.
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1998: Khwaja A; Lehmann K; Marte B M; Downward J
Phosphoinositide 3-kinase induces scattering and tubulogenesis in epithelial cells through a novel pathway.
The Journal of biological chemistry 1998;273(30):18793-801.
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1998: Downward J
Lipid-regulated kinases: some common themes at last.
Science (New York, N.Y.) 1998;279(5351):673-4.
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1997: Khwaja A; Downward J
Lack of correlation between activation of Jun-NH2-terminal kinase and induction of apoptosis after detachment of epithelial cells.
The Journal of cell biology 1997;139(4):1017-23.
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1997: Marte B M; Downward J
PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond.
Trends in biochemical sciences 1997;22(9):355-8.
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1997: Douville E; Downward J
EGF induced SOS phosphorylation in PC12 cells involves P90 RSK-2.
Oncogene 1997;15(4):373-83.
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1997: Khwaja A; Rodriguez-Viciana P; Wennström S; Warne P H; Downward J
Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway.
The EMBO journal 1997;16(10):2783-93.
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1997: Rodriguez-Viciana P; Warne P H; Khwaja A; Marte B M; Pappin D; Das P; Waterfield M D; Ridley A; Downward J
Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras.
Cell 1997;89(3):457-67.
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1997: Downward J
Cell cycle: routine role for Ras.
Current biology : CB 1997;7(4):R258-60.
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1997: Vanhaesebroeck B; Welham M J; Kotani K; Stein R; Warne P H; Zvelebil M J; Higashi K; Volinia S; Downward J; Waterfield M D
P110delta, a novel phosphoinositide 3-kinase in leukocytes.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(9):4330-5.
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1997: Kauffmann-Zeh A; Rodriguez-Viciana P; Ulrich E; Gilbert C; Coffer P; Downward J; Evan G
Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.
Nature 1997;385(6616):544-8.
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1997: Marte B M; Rodriguez-Viciana P; Wennström S; Warne P H; Downward J
R-Ras can activate the phosphoinositide 3-kinase but not the MAP kinase arm of the Ras effector pathways.
Current biology : CB 1997;7(1):63-70.
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1996: Khwaja A; Hallberg B; Warne P H; Downward J
Networks of interaction of p120cbl and p130cas with Crk and Grb2 adaptor proteins.
Oncogene 1996;12(12):2491-8.
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1996: Rodriguez-Viciana P; Warne P H; Vanhaesebroeck B; Waterfield M D; Downward J
Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation.
The EMBO journal 1996;15(10):2442-51.
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1996: Buday L; Khwaja A; Sipeki S; Faragó A; Downward J
Interactions of Cbl with two adapter proteins, Grb2 and Crk, upon T cell activation.
The Journal of biological chemistry 1996;271(11):6159-63.
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1996: Rodriguez-Viciana P; Marte B M; Warne P H; Downward J
Phosphatidylinositol 3' kinase: one of the effectors of Ras.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1996;351(1336):225-31; discussion 231-2.
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1996: Downward J
Control of ras activation.
Cancer surveys 1996;27():87-100.
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1995: de Vries-Smits A M; van der Voorn; Downward J; Bos J L
Measurements of GTP/GDP exchange in permeabilized fibroblasts.
Methods in enzymology 1995;255():156-61.
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1995: Downward J
Measurement of nucleotide exchange and hydrolysis activities in immunoprecipitates.
Methods in enzymology 1995;255():110-7.
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1994: Basu T; Warne P H; Downward J
Role of Shc in the activation of Ras in response to epidermal growth factor and nerve growth factor.
Oncogene 1994;9(12):3483-91.
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1994: Arvidsson A K; Rupp E; Nånberg E; Downward J; Rönnstrand L; Wennström S; Schlessinger J; Heldin C H; Claesson-Welsh L
Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation.
Molecular and cellular biology 1994;14(10):6715-26.
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1994: Kodaki T; Woscholski R; Hallberg B; Rodriguez-Viciana P; Downward J; Parker P J
The activation of phosphatidylinositol 3-kinase by Ras.
Current biology : CB 1994;4(9):798-806.
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1994: Rodriguez-Viciana P; Warne P H; Dhand R; Vanhaesebroeck B; Gout I; Fry M J; Waterfield M D; Downward J
Phosphatidylinositol-3-OH kinase as a direct target of Ras.
Nature 1994;370(6490):527-32.
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1994: Reif K; Buday L; Downward J; Cantrell D A
SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and a 75-kDa protein that is a substrate for T cell antigen receptor-activated tyrosine kinases.
The Journal of biological chemistry 1994;269(19):14081-7.
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1994: Pronk G J; de Vries-Smits A M; Buday L; Downward J; Maassen J A; Medema R H; Bos J L
Involvement of Shc in insulin- and epidermal growth factor-induced activation of p21ras.
Molecular and cellular biology 1994;14(3):1575-81.
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1994: Buday L; Egan S E; Rodriguez Viciana P; Cantrell D A; Downward J
A complex of Grb2 adaptor protein, Sos exchange factor, and a 36-kDa membrane-bound tyrosine phosphoprotein is implicated in ras activation in T cells.
The Journal of biological chemistry 1994;269(12):9019-23.
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1994: Hallberg B; Rayter S I; Downward J
Interaction of Ras and Raf in intact mammalian cells upon extracellular stimulation.
The Journal of biological chemistry 1994;269(6):3913-6.
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1994: Downward J
The GRB2/Sem-5 adaptor protein.
FEBS letters 1994;338(2):113-7.
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1993: Warne P H; Viciana P R; Downward J
Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro.
Nature 1993;364(6435):352-5.
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1993: Buday L; Downward J
Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor.
Cell 1993;73(3):611-20.
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1993: Woodrow M A; Rayter S; Downward J; Cantrell D A
p21ras function is important for T cell antigen receptor and protein kinase C regulation of nuclear factor of activated T cells.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(9):3853-61.
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1993: Buday L; Downward J
Epidermal growth factor regulates the exchange rate of guanine nucleotides on p21ras in fibroblasts.
Molecular and cellular biology 1993;13(3):1903-10.
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1992: Rayter S I; Woodrow M; Lucas S C; Cantrell D A; Downward J
p21ras mediates control of IL-2 gene promoter function in T cell activation.
The EMBO journal 1992;11(12):4549-56.
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1992: Izquierdo M; Downward J; Graves J D; Cantrell D A
Role of protein kinase C in T-cell antigen receptor regulation of p21ras: evidence that two p21ras regulatory pathways coexist in T cells.
Molecular and cellular biology 1992;12(7):3305-12.
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1992: Basu T N; Gutmann D H; Fletcher J A; Glover T W; Collins F S; Downward J
Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients.
Nature 1992;356(6371):713-5.
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1992: Graves J D; Downward J; Izquierdo-Pastor M; Rayter S; Warne P H; Cantrell D A
The growth factor IL-2 activates p21ras proteins in normal human T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(8):2417-22.
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1992: Izquierdo M; Downward J; Otani H; Leonard W J; Cantrell D A
Interleukin (IL)-2 activation of p21ras in murine myeloid cells transfected with human IL-2 receptor beta chain.
European journal of immunology 1992;22(3):817-21.
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1992: Downward J
Regulation of p21ras by GTPase activating proteins and guanine nucleotide exchange proteins.
Current opinion in genetics & development 1992;2(1):13-8.
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1992: Cantrell D A; Graves J D; Izquierdo M; Lucas S; Downward J
T lymphocyte activation signals.
Ciba Foundation symposium 1992;164():208-18; discussion 218-22.
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1991: Graves J D; Downward J; Rayter S; Warne P; Tutt A L; Glennie M; Cantrell D A
CD2 antigen mediated activation of the guanine nucleotide binding proteins p21ras in human T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(11):3709-12.
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1990: Downward J
The ras superfamily of small GTP-binding proteins.
Trends in biochemical sciences 1990;15(12):469-72.
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1990: Downward J; Graves J D; Warne P H; Rayter S; Cantrell D A
Stimulation of p21ras upon T-cell activation.
Nature 1990;346(6286):719-23.
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1989: Hsuan J J; Downward J; Clark S; Waterfield M D
Proteolytic generation of constitutive tyrosine kinase activity of the human insulin receptor.
The Biochemical journal 1989;259(2):519-27.
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