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Mitch Dowsett
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Network (preview)
39
Smith, Ian
32
Johnston, Stephen
31
Salter, Janine
30
Powles, Trevor
25
Detre, Simone
23
Folkerd, Elizabeth
14
Ormerod, Michael
14
Jarman, Michael
13
Martin, Lesley-Ann
12
A'Hern, Roger
12
Ashworth, Alan
11
Ashley, SE
11
Coombes, Charles
11
Hills, Margaret
10
Haynes, BP
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All Publications
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2009: Penault-Llorca Frédérique; Bilous Michael; Dowsett Mitch; Hanna Wedad; Osamura Robert Yoshiyuki; Rüschoff Josef; van de Vijver Marc
Emerging technologies for assessing HER2 amplification.
American journal of clinical pathology 2009;132(4):539-48.
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2009: Attard Gerhardt; Reid Alison H M; A'Hern Roger; Parker Christopher; Oommen Nikhil Babu; Folkerd Elizabeth; Messiou Christina; Molife L Rhoda; Maier Gal; Thompson Emilda; Olmos David; Sinha Rajesh; Lee Gloria; Dowsett Mitch; Kaye Stan B; Dearnaley David; Kheoh Thian; Molina Arturo; de Bono Johann S
Selective inhibition of CYP17 with abiraterone acetate is highly active in the treatment of castration-resistant prostate cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(23):3742-8.
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2009: Banerjee Susana; Zvelebil Marketa; Furet Pascal; Mueller-Vieira Ursula; Evans Dean B; Dowsett Mitch; Martin Lesley-Ann
The vascular endothelial growth factor receptor inhibitor PTK787/ZK222584 inhibits aromatase.
Cancer research 2009;69(11):4716-23.
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2009: Drury Suzanne; Anderson Helen; Dowsett Mitch
Selection of REFERENCE genes for normalization of qRT-PCR data derived from FFPE breast tumors.
Diagnostic molecular pathology : the American journal of surgical pathology, part B 2009;18(2):103-7.
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2009: Dowsett Mitch; Procter Marion; McCaskill-Stevens Worta; de Azambuja Evandro; Dafni Urania; Rueschoff Josef; Jordan Bruce; Dolci Stella; Abramovitz Mark; Stoss Oliver; Viale Giuseppe; Gelber Richard D; Piccart-Gebhart Martine; Leyland-Jones Brian
Disease-free survival according to degree of HER2 amplification for patients treated with adjuvant chemotherapy with or without 1 year of trastuzumab: the HERA Trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(18):2962-9.
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2009: Leary Alexandra F; Hanna Wedad M; van de Vijver Marc J; Penault-Llorca Frederique; Rüschoff Josef; Osamura Robert Y; Bilous Michael; Dowsett Mitch
Value and limitations of measuring HER-2 extracellular domain in the serum of breast cancer patients.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(10):1694-705.
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2009: Murray J; Young O E; Renshaw L; White S; Williams L; Evans D B; Thomas J St J; Dowsett M; Dixon J M
A randomised study of the effects of letrozole and anastrozole on oestrogen receptor positive breast cancers in postmenopausal women.
Breast cancer research and treatment 2009;114(3):495-501.
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2009: McCormack Valerie A; Dowsett Mitch; Folkerd Elizabeth; Johnson Nichola; Palles Claire; Coupland Ben; Holly Jeff M; Vinnicombe Sarah J; Perry Nicholas M; dos Santos Silva Isabel
Sex steroids, growth factors and mammographic density: a cross-sectional study of UK postmenopausal Caucasian and Afro-Caribbean women.
Breast cancer research : BCR 2009;11(3):R38.
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2009: Roddam Andrew W; Appleby Paul; Neale Rachel; Dowsett Mitch; Folkerd Elizabeth; Tipper Sarah; Allen Naomi E; Key Timothy J
Association between endogenous plasma hormone concentrations and fracture risk in men and women: the EPIC-Oxford prospective cohort study.
Journal of bone and mineral metabolism 2009;27(4):485-93.
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2008: Pancholi Sunil; Lykkesfeldt Anne E; Hilmi Caroline; Banerjee Susana; Leary Alexandra; Drury Suzanne; Johnston Stephen; Dowsett Mitch; Martin Lesley-Ann
ERBB2 influences the subcellular localization of the estrogen receptor in tamoxifen-resistant MCF-7 cells leading to the activation of AKT and RPS6KA2.
Endocrine-related cancer 2008;15(4):985-1002.
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2008: Ellis Matthew J; Tao Yu; Luo Jingqin; A'Hern Roger; Evans Dean B; Bhatnagar Ajay S; Chaudri Ross Hilary A; von Kameke Alexander; Miller William R; Smith Ian; Eiermann Wolfgang; Dowsett Mitch
Outcome prediction for estrogen receptor-positive breast cancer based on postneoadjuvant endocrine therapy tumor characteristics.
Journal of the National Cancer Institute 2008;100(19):1380-8.
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2008: Attard Gerhardt; Reid Alison H M; Yap Timothy A; Raynaud Florence; Dowsett Mitch; Settatree Sarah; Barrett Mary; Parker Christopher; Martins Vanessa; Folkerd Elizabeth; Clark Jeremy; Cooper Colin S; Kaye Stan B; Dearnaley David; Lee Gloria; de Bono Johann S
Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(28):4563-71.
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2008: Tan David S P; Marchió Caterina; Jones Robin L; Savage Kay; Smith Ian E; Dowsett Mitch; Reis-Filho Jorge S
Triple negative breast cancer: molecular profiling and prognostic impact in adjuvant anthracycline-treated patients.
Breast cancer research and treatment 2008;111(1):27-44.
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2008: Urruticoechea Ander; Arnedos Monica; Walsh Geraldine; Dowsett Mitch; Smith Ian E
Ovarian protection with goserelin during adjuvant chemotherapy for pre-menopausal women with early breast cancer (EBC).
Breast cancer research and treatment 2008;110(3):411-6.
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2008: Reis-Filho Jorge S; Drury Suzanne; Lambros Maryou B; Marchio Caterina; Johnson Nichola; Natrajan Rachael; Salter Janine; Levey Pauline; Fletcher Olivia; Peto Julian; Ashworth Alan; Dowsett Mitch
ESR1 gene amplification in breast cancer: a common phenomenon?
Nature genetics 2008;40(7):809-10; author reply 810-2.
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2008: Fiegl Heidi; Jones Allison; Hauser-Kronberger Cornelia; Hutarew Georg; Reitsamer Roland; Jones Robin L; Dowsett Mitch; Mueller-Holzner Elisabeth; Windbichler Gudrun; Daxenbichler Günter; Goebel Georg; Ensinger Christian; Jacobs Ian; Widschwendter Martin
Methylated NEUROD1 promoter is a marker for chemosensitivity in breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(11):3494-502.
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2008: Urruticoechea Ander; Aguilar Helena; Solé Xavier; Capellà Gabriel; Martin Lesley-Ann; Dowsett Mitch; Germà-Lluch Josep Ramon
Pre-clinical validation of early molecular markers of sensitivity to aromatase inhibitors in a mouse model of post-menopausal hormone-sensitive breast cancer.
Breast cancer research and treatment 2008;109(3):463-70.
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2008: Banerjee Susana; Pancholi Sunil; A'hern Roger; Ghazoui Zara; Smith Ian E; Dowsett Mitch; Martin Lesley-Ann
The effects of neoadjuvant anastrozole and tamoxifen on circulating vascular endothelial growth factor and soluble vascular endothelial growth factor receptor 1 in breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(9):2656-63.
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2008: Arriola Edurne; Marchio Caterina; Tan David S P; Drury Suzanne C; Lambros Maryou B; Natrajan Rachael; Rodriguez-Pinilla Socorro Maria; Mackay Alan; Tamber Narinder; Fenwick Kerry; Jones Chris; Dowsett Mitch; Ashworth Alan; Reis-Filho Jorge S
Genomic analysis of the HER2/TOP2A amplicon in breast cancer and breast cancer cell lines.
Laboratory investigation; a journal of technical methods and pathology 2008;88(5):491-503.
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2008: Kendall Anne; Anderson Helen; Dunbier Anita K; Mackay Alan; Dexter Tim; Urruticoechea Ander; Harper-Wynne Catherine; Dowsett Mitch
Impact of estrogen deprivation on gene expression profiles of normal postmenopausal breast tissue in vivo.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008;17(4):855-63.
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2008: Dixon J Michael; Renshaw Lorna; Young Oliver; Murray Juliette; Macaskill E Jane; McHugh Mary; Folkerd Elizabeth; Cameron David A; A'Hern Roger P; Dowsett Mitch
Letrozole suppresses plasma estradiol and estrone sulphate more completely than anastrozole in postmenopausal women with breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(10):1671-6.
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2008: Dowsett Mitch; Allred Craig; Knox Jill; Quinn Emma; Salter Janine; Wale Chris; Cuzick Jack; Houghton Joan; Williams Norman; Mallon Elizabeth; Bishop Hugh; Ellis Ian; Larsimont Denis; Sasano Hironobu; Carder Pauline; Cussac Antonio Llombart; Knox Fiona; Speirs Valerie; Forbes John; Buzdar Aman
Relationship between quantitative estrogen and progesterone receptor expression and human epidermal growth factor receptor 2 (HER-2) status with recurrence in the Arimidex, Tamoxifen, Alone or in Combination trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(7):1059-65.
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2008: Chan Mei-Fen; Dowsett Mitch; Folkerd Elizabeth; Wareham Nicholas; Luben Robert; Welch Ailsa; Bingham Sheila; Khaw Kay-Tee
Past oral contraceptive and hormone therapy use and endogenous hormone concentrations in postmenopausal women.
Menopause (New York, N.Y.) 2008;15(2):332-9.
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2008: Johnston Stephen R D; Leary Alexandra; Martin Lesley-Ann; Smith Ian E; Dowsett Mitch
Enhancing endocrine response with novel targeted therapies: why have the clinical trials to date failed to deliver on the preclinical promise?
Cancer 2008;112(3 Suppl):710-7.
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2008: Dowsett Mitch
Introduction to sessions on 'Predicting personal risk for breast cancer'.
Breast cancer research : BCR 2008;10 Suppl 4():S9.
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2008: Dowsett Mitch
Optimizing the implementation of future treatment using surrogate end-points.
Breast cancer research : BCR 2008;10 Suppl 4():S26.
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2007: Khaw Kay-Tee; Dowsett Mitch; Folkerd Elizabeth; Bingham Sheila; Wareham Nicholas; Luben Robert; Welch Ailsa; Day Nicholas
Endogenous testosterone and mortality due to all causes, cardiovascular disease, and cancer in men: European prospective investigation into cancer in Norfolk (EPIC-Norfolk) Prospective Population Study.
Circulation 2007;116(23):2694-701.
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2007: Arriola Edurne; Rodriguez-Pinilla Socorro Maria; Lambros Maryou B K; Jones Robin L; James Michelle; Savage Kay; Smith Ian E; Dowsett Mitch; Reis-Filho Jorge S
Topoisomerase II alpha amplification may predict benefit from adjuvant anthracyclines in HER2 positive early breast cancer.
Breast cancer research and treatment 2007;106(2):181-9.
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2007: Bartlett John M S; Ellis Ian O; Dowsett Mitch; Mallon Elizabeth A; Cameron David A; Johnston Stephen; Hall Emma; A'Hern Roger; Peckitt Clare; Bliss Judith M; Johnson Lindsay; Barrett-Lee Peter; Ellis Paul
Human epidermal growth factor receptor 2 status correlates with lymph node involvement in patients with estrogen receptor (ER) negative, but with grade in those with ER-positive early-stage breast cancer suitable for cytotoxic chemotherapy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(28):4423-30.
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2007: Martin Lesley-Ann; Head Julia E; Pancholi Sunil; Salter Janine; Quinn Emma; Detre Simone; Kaye Stan; Howes Angela; Dowsett Mitch; Johnston Stephen R D
The farnesyltransferase inhibitor R115777 (tipifarnib) in combination with tamoxifen acts synergistically to inhibit MCF-7 breast cancer cell proliferation and cell cycle progression in vitro and in vivo.
Molecular cancer therapeutics 2007;6(9):2458-67.
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2007: Banerjee Susana; Dowsett Mitch; Ashworth Alan; Martin Lesley-Ann
Mechanisms of disease: angiogenesis and the management of breast cancer.
Nature clinical practice. Oncology 2007;4(9):536-50.
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2007: Smith Ian E; Walsh Geraldine; Skene Anthony; Llombart Antonio; Mayordomo José Ignacio; Detre Simone; Salter Janine; Clark Emma; Magill Patrick; Dowsett Mitch
A phase II placebo-controlled trial of neoadjuvant anastrozole alone or with gefitinib in early breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(25):3816-22.
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2007: Tworoger Shelley S; Missmer Stacey A; Eliassen A Heather; Barbieri Robert L; Dowsett Mitch; Hankinson Susan E
Physical activity and inactivity in relation to sex hormone, prolactin, and insulin-like growth factor concentrations in premenopausal women - exercise and premenopausal hormones.
Cancer causes & control : CCC 2007;18(7):743-52.
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2007: Ellis Matthew J; Dixon Michael; Dowsett Mitch; Nagarajan Rakesh; Mardis Elaine
A luminal breast cancer genome atlas: progress and barriers.
The Journal of steroid biochemistry and molecular biology 2007;106(1-5):125-9.
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2007: Johnston Stephen R D; Martin Lesley-Ann; Leary Alex; Head Julia; Dowsett Mitch
Clinical strategies for rationale combinations of aromatase inhibitors with novel therapies for breast cancer.
The Journal of steroid biochemistry and molecular biology 2007;106(1-5):180-6.
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2007: Anderson Helen; Bulun Serdar; Smith Ian; Dowsett Mitch
Predictors of response to aromatase inhibitors.
The Journal of steroid biochemistry and molecular biology 2007;106(1-5):49-54.
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2007: Kubista Ernst; Planellas Gomez Juan V M; Dowsett Mitch; Foidart Jean-Michel; Pohlodek Kamil; Serreyn Rudolphe; Nechushkin Michail; Manikhas Alexey G; Semiglazov Victor F; Hageluken Cornelius C M; Singer Christian F
Effect of tibolone on breast cancer cell proliferation in postmenopausal ER+ patients: results from STEM trial.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(14):4185-90.
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2007: Santen Richard J; Boyd Norman F; Chlebowski Rowan T; Cummings Steven; Cuzick Jack; Dowsett Mitch; Easton Douglas; Forbes John F; Key Tim; Hankinson Susan E; Howell Anthony; Ingle James;
Critical assessment of new risk factors for breast cancer: considerations for development of an improved risk prediction model.
Endocrine-related cancer 2007;14(2):169-87.
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2007: Jones Michael E; Folkerd Elizabeth J; Doody Deborah A; Iqbal Jhangir; Dowsett Mitch; Ashworth Alan; Swerdlow Anthony J
Effect of delays in processing blood samples on measured endogenous plasma sex hormone levels in women.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007;16(6):1136-9.
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2007: Dowsett Mitch; Hanby A M; Laing R; Walker R;
HER2 testing in the UK: consensus from a national consultation.
Journal of clinical pathology 2007;60(6):685-9.
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2007: Low Yen-Ling; Dunning Alison M; Dowsett Mitch; Folkerd Elizabeth; Doody Deborah; Taylor James; Bhaniani Amit; Luben Robert; Khaw Kay-Tee; Wareham Nick J; Bingham Sheila A
Phytoestrogen exposure is associated with circulating sex hormone levels in postmenopausal women and interact with ESR1 and NR1I2 gene variants.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007;16(5):1009-16.
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2007: Chan Mei-Fen; Dowsett Mitch; Folkerd Elizabeth; Bingham Sheila; Wareham Nicholas; Luben Robert; Welch Ailsa; Khaw Kay-Tee
Usual physical activity and endogenous sex hormones in postmenopausal women: the European prospective investigation into cancer-norfolk population study.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007;16(5):900-5.
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2007: Dowsett Mitch; Hanna Wedad M; Kockx Mark; Penault-Llorca Frederique; Rüschoff Josef; Gutjahr Thorsten; Habben Kai; van de Vijver Marc J
Standardization of HER2 testing: results of an international proficiency-testing ring study.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2007;20(5):584-91.
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2007: Geisler Jürgen; Haynes Ben; Ekse Dagfinn; Dowsett Mitch; Lønning Per Eystein
Total body aromatization in postmenopausal breast cancer patients is strongly correlated to plasma leptin levels.
The Journal of steroid biochemistry and molecular biology 2007;104(1-2):27-34.
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2007: Arriola E; Hui E; Dowsett M; Smith I E
Aromatase inhibitors and male breast cancer.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2007;9(3):192-4.
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2007: Kote-Jarai Zsofia; Powles Trevor J; Mitchell Gillian; Tidy Alwynne; Ashley Sue; Easton Douglas; Assersohn Laura; Sodha Nayanta; Salter Janine; Gusterson Barry; Dowsett Mitch; Eeles Rosalind
BRCA1/BRCA2 mutation status and analysis of cancer family history in participants of the Royal Marsden Hospital tamoxifen chemoprevention trial.
Cancer letters 2007;247(2):259-65.
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2007: Powles Trevor J; Ashley Sue; Tidy Alwynne; Smith Ian E; Dowsett Mitch
Twenty-year follow-up of the Royal Marsden randomized, double-blinded tamoxifen breast cancer prevention trial.
Journal of the National Cancer Institute 2007;99(4):283-90.
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2007: Kendall Anne; Folkerd Elizabeth J; Dowsett Mitch
Influences on circulating oestrogens in postmenopausal women: relationship with breast cancer.
The Journal of steroid biochemistry and molecular biology 2007;103(2):99-109.
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2007: Dowsett Mitch; Smith Ian E; Ebbs Stephen R; Dixon J Michael; Skene Anthony; A'Hern Roger; Salter Janine; Detre Simone; Hills Margaret; Walsh Geraldine;
Prognostic value of Ki67 expression after short-term presurgical endocrine therapy for primary breast cancer.
Journal of the National Cancer Institute 2007;99(2):167-70.
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2007: Smith Ian; Procter Marion; Gelber Richard D; Guillaume Sébastien; Feyereislova Andrea; Dowsett Mitch; Goldhirsch Aron; Untch Michael; Mariani Gabriella; Baselga Jose; Kaufmann Manfred; Cameron David; Bell Richard; Bergh Jonas; Coleman Robert; Wardley Andrew; Harbeck Nadia; Lopez Roberto I; Mallmann Peter; Gelmon Karen; Wilcken Nicholas; Wist Erik; Sánchez Rovira Pedro; Piccart-Gebhart Martine J;
2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial.
Lancet 2007;369(9555):29-36.
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2007: Arriola Edurne; Lambros Maryou B K; Jones Chris; Dexter Tim; Mackay Alan; Tan David S P; Tamber Narinder; Fenwick Kerry; Ashworth Alan; Dowsett Mitch; Reis-Filho Jorge S
Evaluation of Phi29-based whole-genome amplification for microarray-based comparative genomic hybridisation.
Laboratory investigation; a journal of technical methods and pathology 2007;87(1):75-83.
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2007: Pierga J-Y; Reis-Filho J S; Cleator S J; Dexter T; Mackay A; Simpson P; Fenwick K; Iravani M; Salter J; Hills M; Jones C; Ashworth A; Smith I E; Powles T; Dowsett M
Microarray-based comparative genomic hybridisation of breast cancer patients receiving neoadjuvant chemotherapy.
British journal of cancer 2007;96(2):341-51.
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2007: Kaptoge S; Dalzell N; Folkerd E; Doody D; Khaw K-T; Beck T J; Loveridge N; Mawer E B; Berry J L; Shearer M J; Dowsett M; Reeve J
Sex hormone status may modulate rate of expansion of proximal femur diameter in older women alongside other skeletal regulators.
The Journal of clinical endocrinology and metabolism 2007;92(1):304-13.
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2007: Dowsett Mitch; Goldhirsch Aron; Hayes Daniel F; Senn Hans-Joerg; Wood William; Viale Giuseppe
International Web-based consultation on priorities for translational breast cancer research.
Breast cancer research : BCR 2007;9(6):R81.
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2007: Mackay Alan; Urruticoechea Ander; Dixon J Michael; Dexter Tim; Fenwick Kerry; Ashworth Alan; Drury Suzanne; Larionov Alexey; Young Oliver; White Sharon; Miller William R; Evans Dean B; Dowsett Mitch
Molecular response to aromatase inhibitor treatment in primary breast cancer.
Breast cancer research : BCR 2007;9(3):R37.
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2006: Tworoger Shelley S; Eliassen A Heather; Missmer Stacey A; Baer Heather; Rich-Edwards Janet; Michels Karin B; Barbieri Robert L; Dowsett Mitch; Hankinson Susan E
Birthweight and body size throughout life in relation to sex hormones and prolactin concentrations in premenopausal women.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2006;15(12):2494-501.
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2006: Dowsett Mitch
Estrogen receptor: methodology matters.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(36):5626-8.
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2006: Folkerd Elizabeth J; Martin Lesley-Ann; Kendall Anne; Dowsett Mitch
The relationship between factors affecting endogenous oestradiol levels in postmenopausal women and breast cancer.
The Journal of steroid biochemistry and molecular biology 2006;102(1-5):250-5.
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2006: Eliassen A Heather; Missmer Stacey A; Tworoger Shelley S; Spiegelman Donna; Barbieri Robert L; Dowsett Mitch; Hankinson Susan E
Endogenous steroid hormone concentrations and risk of breast cancer among premenopausal women.
Journal of the National Cancer Institute 2006;98(19):1406-15.
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2006: Lee Jennifer S; Ettinger Bruce; Stanczyk Frank Z; Vittinghoff Eric; Hanes Vladimir; Cauley Jane A; Chandler Walt; Settlage Jim; Beattie Mary S; Folkerd Elizabeth; Dowsett Mitch; Grady Deborah; Cummings Steven R
Comparison of methods to measure low serum estradiol levels in postmenopausal women.
The Journal of clinical endocrinology and metabolism 2006;91(10):3791-7.
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2006: Low Yen-Ling; Dunning Alison M; Dowsett Mitch; Luben Robert N; Khaw Kay-Tee; Wareham Nick J; Bingham Sheila A
Implications of gene-environment interaction in studies of gene variants in breast cancer: an example of dietary isoflavones and the D356N polymorphism in the sex hormone-binding globulin gene.
Cancer research 2006;66(18):8980-3.
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2006: Kendall Anne; Dowsett Mitch
Novel concepts for the chemoprevention of breast cancer through aromatase inhibition.
Endocrine-related cancer 2006;13(3):827-37.
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2006: Leary A; Dowsett M
Combination therapy with aromatase inhibitors: the next era of breast cancer treatment?
British journal of cancer 2006;95(6):661-6.
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2006: Warren Ruth; Skinner Jane; Sala Evis; Denton Erika; Dowsett Mitch; Folkerd Elizabeth; Healey Catherine S; Dunning Alison; Doody Deborah; Ponder Bruce; Luben Robert N; Day N E; Easton Douglas
Associations among mammographic density, circulating sex hormones, and polymorphisms in sex hormone metabolism genes in postmenopausal women.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2006;15(8):1502-8.
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2006: Eastell Richard; Hannon Rosemary A; Cuzick Jack; Dowsett Mitch; Clack Glen; Adams Judith E;
Effect of an aromatase inhibitor on bmd and bone turnover markers: 2-year results of the Anastrozole, Tamoxifen, Alone or in Combination (ATAC) trial (18233230).
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2006;21(8):1215-23.
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2006: Ellis Matthew J; Tao Yu; Young Oliver; White Sharon; Proia Alan D; Murray Julliette; Renshaw Lorna; Faratian Dana; Thomas Jeremy; Dowsett Mitch; Krause Andreas; Evans Dean B; Miller William R; Dixon J Michael
Estrogen-independent proliferation is present in estrogen-receptor HER2-positive primary breast cancer after neoadjuvant letrozole.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(19):3019-25.
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2006: Amin Sanober A; Huang Chiang-Ching; Reierstad Scott; Lin Zhihong; Arbieva Zarema; Wiley Elizabeth; Saborian Hossain; Haynes Ben; Cotterill Helen; Dowsett Mitch; Bulun Serdar E
Paracrine-stimulated gene expression profile favors estradiol production in breast tumors.
Molecular and cellular endocrinology 2006;253(1-2):44-55.
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2006: Reis-Filho Jorge S; Savage Kay; Lambros Maryou B K; James Michelle; Steele Dawn; Jones Robin L; Dowsett Mitch
Cyclin D1 protein overexpression and CCND1 amplification in breast carcinomas: an immunohistochemical and chromogenic in situ hybridisation analysis.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2006;19(7):999-1009.
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2006: Smith Ian E; Dowsett Mitch; Yap Yoon-Sim; Walsh Geraldine; Lønning Per E; Santen Richard J; Hayes Daniel
Adjuvant aromatase inhibitors for early breast cancer after chemotherapy-induced amenorrhoea: caution and suggested guidelines.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(16):2444-7.
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2006: Tworoger Shelley S; Missmer Stacey A; Eliassen A Heather; Spiegelman Donna; Folkerd Elizabeth; Dowsett Mitch; Barbieri Robert L; Hankinson Susan E
The association of plasma DHEA and DHEA sulfate with breast cancer risk in predominantly premenopausal women.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2006;15(5):967-71.
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2006: Dowsett M; Houghton J; Iden C; Salter J; Farndon J; A'Hern R; Sainsbury R; Baum M
Benefit from adjuvant tamoxifen therapy in primary breast cancer patients according oestrogen receptor, progesterone receptor, EGF receptor and HER2 status.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2006;17(5):818-26.
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2006: Kendall A; Dowsett M; Folkerd E; Smith I
Caution: Vaginal estradiol appears to be contraindicated in postmenopausal women on adjuvant aromatase inhibitors.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2006;17(4):584-7.
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2006: Schernhammer Eva S; Kroenke Candyce H; Dowsett Mitch; Folkerd Elizabeth; Hankinson Susan E
Urinary 6-sulfatoxymelatonin levels and their correlations with lifestyle factors and steroid hormone levels.
Journal of pineal research 2006;40(2):116-24.
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2006: Dowsett Mitch; Smith Ian E; Ebbs Steve R; Dixon J Michael; Skene Anthony; Griffith Clive; Boeddinghaus Irene; Salter Janine; Detre Simone; Hills Margaret; Ashley Susan; Francis Stephen; Walsh Geraldine; A'Hern Roger
Proliferation and apoptosis as markers of benefit in neoadjuvant endocrine therapy of breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(3 Pt 2):1024s-1030s.
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2006: Come Steven E; Buzdar Aman U; Ingle James N; Arteaga Carlos L; Brown Myles; Dowsett Mitch; Hilsenbeck Susan G; Kumar Rakesh; Johnston Stephen R D; Lee Adrian V; Paik Soonmyung; Pritchard Kathleen I; Winer Eric P; Hart Carol
Proceedings of the Fifth International Conference on Recent Advances and Future Directions in Endocrine Therapy for Breast Cancer: conference summary statement.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(3 Pt 2):997s-1000s.
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2006: Cleator Susan; Tsimelzon Anna; Ashworth Alan; Dowsett Mitch; Dexter Timothy; Powles Trevor; Hilsenbeck Susan; Wong Helen; Osborne C Kent; O'Connell Peter; Chang Jenny C
Gene expression patterns for doxorubicin (Adriamycin) and cyclophosphamide (cytoxan) (AC) response and resistance.
Breast cancer research and treatment 2006;95(3):229-33.
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2006: Beattie Mary S; Costantino Joseph P; Cummings Steven R; Wickerham D Lawrence; Vogel Victor G; Dowsett Mitch; Folkerd Elizabeth J; Willett Walter C; Wolmark Norman; Hankinson Susan E
Endogenous sex hormones, breast cancer risk, and tamoxifen response: an ancillary study in the NSABP Breast Cancer Prevention Trial (P-1).
Journal of the National Cancer Institute 2006;98(2):110-5.
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2006: Cleator Susan J; Powles Trevor J; Dexter Tim; Fulford Laura; Mackay Alan; Smith Ian E; Valgeirsson Haukur; Ashworth Alan; Dowsett Mitch
The effect of the stromal component of breast tumours on prediction of clinical outcome using gene expression microarray analysis.
Breast cancer research : BCR 2006;8(3):R32.
-
2006: Burcombe Russell; Wilson George D; Dowsett Mitch; Khan Ifty; Richman Paul I; Daley Frances; Detre Simone; Makris Andreas
Evaluation of Ki-67 proliferation and apoptotic index before, during and after neoadjuvant chemotherapy for primary breast cancer.
Breast cancer research : BCR 2006;8(3):R31.
-
2005: Martin L-A; Pancholi S; Chan C M W; Farmer I; Kimberley C; Dowsett M; Johnston S R D
The anti-oestrogen ICI 182,780, but not tamoxifen, inhibits the growth of MCF-7 breast cancer cells refractory to long-term oestrogen deprivation through down-regulation of oestrogen receptor and IGF signalling.
Endocrine-related cancer 2005;12(4):1017-36.
-
2005: Dowsett Mitch; Folkerd Elizabeth; Doody Deborah; Haynes Ben
The biology of steroid hormones and endocrine treatment of breast cancer.
Breast (Edinburgh, Scotland) 2005;14(6):452-7.
-
2005: Low Yen-Ling; Taylor James I; Grace Philip B; Dowsett Mitch; Folkerd Elizabeth; Doody Deborah; Dunning Alison M; Scollen Serena; Mulligan Angela A; Welch Ailsa A; Luben Robert N; Khaw Kay-Tee; Day Nick E; Wareham Nick J; Bingham Sheila A
Polymorphisms in the CYP19 gene may affect the positive correlations between serum and urine phytoestrogen metabolites and plasma androgen concentrations in men.
The Journal of nutrition 2005;135(11):2680-6.
-
2005: Dowsett Mitch; Cuzick Jack; Wale Chris; Howell Tony; Houghton Joan; Baum Michael
Retrospective analysis of time to recurrence in the ATAC trial according to hormone receptor status: an hypothesis-generating study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(30):7512-7.
-
2005: Urruticoechea Ander; Smith Ian E; Dowsett Mitch
Proliferation marker Ki-67 in early breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(28):7212-20.
-
2005: Geisler Jürgen; Haynes Ben; Anker Gun; Helle Hildegunn; Ekse Dagfinn; Dowsett Mitch; Lønning Per Eystein
Treatment with high-dose estrogen (diethylstilbestrol) significantly decreases plasma estrogen and androgen levels but does not influence in vivo aromatization in postmenopausal breast cancer patients.
The Journal of steroid biochemistry and molecular biology 2005;96(5):415-22.
-
2005: Smith Ian E; Dowsett Mitch; Ebbs Stephen R; Dixon J Michael; Skene Anthony; Blohmer J-U; Ashley Susan E; Francis Stephen; Boeddinghaus Irene; Walsh Geraldine;
Neoadjuvant treatment of postmenopausal breast cancer with anastrozole, tamoxifen, or both in combination: the Immediate Preoperative Anastrozole, Tamoxifen, or Combined with Tamoxifen (IMPACT) multicenter double-blind randomized trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(22):5108-16.
-
2005: Martin Lesley-Ann; Farmer Ian; Johnston Stephen R D; Ali Simak; Dowsett Mitch
Elevated ERK1/ERK2/estrogen receptor cross-talk enhances estrogen-mediated signaling during long-term estrogen deprivation.
Endocrine-related cancer 2005;12 Suppl 1():S75-84.
-
2005: Dowsett M; Johnston S; Martin L-A; Salter J; Hills M; Detre S; Gutierrez M C; Mohsin S K; Shou J; Allred D C; Schiff R; Osborne C K; Smith I
Growth factor signalling and response to endocrine therapy: the Royal Marsden Experience.
Endocrine-related cancer 2005;12 Suppl 1():S113-7.
-
2005: Johnston Stephen R D; Martin Lesley-Ann; Head Julia; Smith Ian; Dowsett Mitch
Aromatase inhibitors: combinations with fulvestrant or signal transduction inhibitors as a strategy to overcome endocrine resistance.
The Journal of steroid biochemistry and molecular biology 2005;95(1-5):173-81.
-
2005: Dowsett Mitch; Martin Lesley-Ann; Smith Ian; Johnston Stephen
Mechanisms of resistance to aromatase inhibitors.
The Journal of steroid biochemistry and molecular biology 2005;95(1-5):167-72.
-
2005: Dowsett Mitch; Ebbs Steve R; Dixon J Michael; Skene Anthony; Griffith Clive; Boeddinghaus Irene; Salter Janine; Detre Simone; Hills Margaret; Ashley Susan; Francis Stephen; Walsh Geraldine; Smith Ian E
Biomarker changes during neoadjuvant anastrozole, tamoxifen, or the combination: influence of hormonal status and HER-2 in breast cancer--a study from the IMPACT trialists.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(11):2477-92.
-
2005: Gutierrez M Carolina; Detre Simone; Johnston Stephen; Mohsin Syed K; Shou Jiang; Allred D Craig; Schiff Rachel; Osborne C Kent; Dowsett Mitch
Molecular changes in tamoxifen-resistant breast cancer: relationship between estrogen receptor, HER-2, and p38 mitogen-activated protein kinase.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(11):2469-76.
-
2005: Ring A E; Zabaglo L; Ormerod M G; Smith I E; Dowsett M
Detection of circulating epithelial cells in the blood of patients with breast cancer: comparison of three techniques.
British journal of cancer 2005;92(5):906-12.
-
2005: Dowsett Mitch; Smith Ian E; Ebbs Steve R; Dixon J Michael; Skene Anthony; Griffith Clive; Boeddinghaus Irene; Salter Janine; Detre Simone; Hills Margaret; Ashley Susan; Francis Stephen; Walsh Geraldine;
Short-term changes in Ki-67 during neoadjuvant treatment of primary breast cancer with anastrozole or tamoxifen alone or combined correlate with recurrence-free survival.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(2 Pt 2):951s-8s.
-
2005: Low Yen-Ling; Taylor James I; Grace Philip B; Dowsett Mitch; Scollen Serena; Dunning Alison M; Mulligan Angela A; Welch Ailsa A; Luben Robert N; Khaw Kay-Tee; Day Nick E; Wareham Nick J; Bingham Sheila A
Phytoestrogen exposure correlation with plasma estradiol in postmenopausal women in European Prospective Investigation of Cancer and Nutrition-Norfolk may involve diet-gene interactions.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2005;14(1):213-20.
-
2005: Esserman Laura J; Ozanne Elissa M; Dowsett Mitch; Slingerland Joyce M
Tamoxifen may prevent both ER+ and ER- breast cancers and select for ER- carcinogenesis: an alternative hypothesis.
Breast cancer research : BCR 2005;7(6):R1153-8.
-
2005: Johnston Stephen R; Martin Lesley-Ann; Dowsett Mitch
Life following aromatase inhibitors--where now for endocrine sequencing?
Breast cancer research and treatment 2005;93 Suppl 1():S19-25.
-
2005: Dowsett Mitch; Nicholson Robert I; Pietras Richard J
Biological characteristics of the pure antiestrogen fulvestrant: overcoming endocrine resistance.
Breast cancer research and treatment 2005;93 Suppl 1():S11-8.
-
2005: Dowsett Mitch; Folkerd Elizabeth
Deficits in plasma oestradiol measurement in studies and management of breast cancer.
Breast cancer research : BCR 2005;7(1):1-4.
-
2004: Ring Alistair; Dowsett Mitch
Mechanisms of tamoxifen resistance.
Endocrine-related cancer 2004;11(4):643-58.
-
2004: Dixon J M; Jackson J; Hills M; Renshaw L; Cameron D A; Anderson T J; Miller W R; Dowsett M
Anastrozole demonstrates clinical and biological effectiveness in oestrogen receptor-positive breast cancers, irrespective of the erbB2 status.
European journal of cancer (Oxford, England : 1990) 2004;40(18):2742-7.
-
2004: Dunning Alison M; Dowsett Mitch; Healey Catherine S; Tee Louise; Luben Robert N; Folkerd Elizabeth; Novik Karen L; Kelemen Livia; Ogata Saeko; Pharoah Paul D P; Easton Douglas F; Day N E; Ponder Bruce A J
Polymorphisms associated with circulating sex hormone levels in postmenopausal women.
Journal of the National Cancer Institute 2004;96(12):936-45.
-
2004: O'Donnell A; Judson I; Dowsett M; Raynaud F; Dearnaley D; Mason M; Harland S; Robbins A; Halbert G; Nutley B; Jarman M
Hormonal impact of the 17alpha-hydroxylase/C(17,20)-lyase inhibitor abiraterone acetate (CB7630) in patients with prostate cancer.
British journal of cancer 2004;90(12):2317-25.
-
2004: Grace Philip B; Taylor James I; Low Yen-Ling; Luben Robert N; Mulligan Angela A; Botting Nigel P; Dowsett Mitch; Welch Ailsa A; Khaw Kay-Tee; Wareham Nick J; Day Nick E; Bingham Sheila A
Phytoestrogen concentrations in serum and spot urine as biomarkers for dietary phytoestrogen intake and their relation to breast cancer risk in European prospective investigation of cancer and nutrition-norfolk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2004;13(5):698-708.
-
2004: Cuzick Jack; Buzdar Aman; Baum Michael; Bianco Raffaele; Coleman Robert; Constenla Manuel; Distler Wolfgang; Dowsett Mitch; Forbes John; Guastalla Jean Paul; Houghton Joan; Williams Norman; Howell Anthony; Locker Gershon; MacKey John; Sainsbury Richard; Tobias Jeffrey
Adjuvant use of anastrozole in breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(8):1524-6; author reply 1526-7.
-
2004: Johnston S R D; Gumbrell L A; Evans T R J; Coleman R E; Smith I E; Twelves C J; Soukop M; Rea D W; Earl H M; Howell A; Jones A; Canney P; Powles T J; Haynes B P; Nutley B; Grimshaw R; Jarman M; Halbert G W; Brampton M; Haviland J; Dowsett M; Coombes R C;
A cancer research (UK) randomized phase II study of idoxifene in patients with locally advanced/metastatic breast cancer resistant to tamoxifen.
Cancer chemotherapy and pharmacology 2004;53(4):341-8.
-
2004: Ring Alistair; Smith Ian E; Dowsett Mitch
Circulating tumour cells in breast cancer.
The lancet oncology 2004;5(2):79-88.
-
2004: Atkinson Charlotte; Compston Juliet E; Day Nicholas E; Dowsett Mitch; Bingham Sheila A
The effects of phytoestrogen isoflavones on bone density in women: a double-blind, randomized, placebo-controlled trial.
The American journal of clinical nutrition 2004;79(2):326-33.
-
2004: Dowsett Mitch
Designing the future shape of breast cancer diagnosis, prognosis and treatment.
Breast cancer research and treatment 2004;87 Suppl 1():S27-9.
-
2004: Dowsett Mitch
Biomarker investigations from the ATAC trial: the role of TA01.
Breast cancer research and treatment 2004;87 Suppl 1():S11-8.
-
2004: Dowsett Mitch
Translational research and the changing face of breast cancer.
Breast cancer research and treatment 2004;87 Suppl 1():S1-2.
-
2004: Howell Anthony; Dowsett Mitch
Endocrinology and hormone therapy in breast cancer: aromatase inhibitors versus antioestrogens.
Breast cancer research : BCR 2004;6(6):269-74.
-
2004: Atkinson Charlotte; Warren Ruth M L; Sala Evis; Dowsett Mitch; Dunning Alison M; Healey Catherine S; Runswick Shirley; Day Nicholas E; Bingham Sheila A
Red-clover-derived isoflavones and mammographic breast density: a double-blind, randomized, placebo-controlled trial [ISRCTN42940165].
Breast cancer research : BCR 2004;6(3):R170-9.
-
2003: Dowsett Mitch
Efforts to link biological and clinical breast cancer research.
Breast (Edinburgh, Scotland) 2003;12(6):442-6.
-
2003: Assersohn L; Salter J; Powles T J; A'hern R; Makris A; Gregory R K; Chang J; Dowsett M
Studies of the potential utility of Ki67 as a predictive molecular marker of clinical response in primary breast cancer.
Breast cancer research and treatment 2003;82(2):113-23.
-
2003: Johnston Stephen R D; Dowsett Mitch
Aromatase inhibitors for breast cancer: lessons from the laboratory.
Nature reviews. Cancer 2003;3(11):821-31.
-
2003: Zabaglo Lila; Ormerod Michael G; Dowsett Mitch
Measurement of proliferation marker Ki67 in breast tumour FNAs using laser scanning cytometry in comparison to conventional immunocytochemistry.
Cytometry. Part B, Clinical cytometry 2003;56(1):55-61.
-
2003: Haynes B P; Dowsett M; Miller W R; Dixon J M; Bhatnagar A S
The pharmacology of letrozole.
The Journal of steroid biochemistry and molecular biology 2003;87(1):35-45.
-
2003: Detre Simone; Riddler Sharon; Salter Janine; A'Hern Roger; Dowsett Mitch; Johnston Stephen R D
Comparison of the selective estrogen receptor modulator arzoxifene (LY353381) with tamoxifen on tumor growth and biomarker expression in an MCF-7 human breast cancer xenograft model.
Cancer research 2003;63(19):6516-22.
-
2003: Zabaglo Lila; Ormerod Michael G; Parton Marina; Ring Alistair; Smith Ian E; Dowsett Mitch
Cell filtration-laser scanning cytometry for the characterisation of circulating breast cancer cells.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2003;55(2):102-8.
-
2003: Dowsett M; Haynes B P
Hormonal effects of aromatase inhibitors: focus on premenopausal effects and interaction with tamoxifen.
The Journal of steroid biochemistry and molecular biology 2003;86(3-5):255-63.
-
2003: Archer C D; Parton M; Smith I E; Ellis P A; Salter J; Ashley S; Gui G; Sacks N; Ebbs S R; Allum W; Nasiri N; Dowsett M
Early changes in apoptosis and proliferation following primary chemotherapy for breast cancer.
British journal of cancer 2003;89(6):1035-41.
-
2003: Dowsett Mitch
Origin and characteristics of adverse events in aromatase inhibition therapy for breast cancer.
Seminars in oncology 2003;30(4 Suppl 14):58-69.
-
2003: Dowsett Mitch; Ellis Matthew J
Role of biologic markers in patient selection and application to disease prevention.
American journal of clinical oncology 2003;26(4):S34-9.
-
2003: Martin Lesley-Ann; Farmer Ian; Johnston Stephen R D; Ali Simak; Marshall Chris; Dowsett Mitch
Enhanced estrogen receptor (ER) alpha, ERBB2, and MAPK signal transduction pathways operate during the adaptation of MCF-7 cells to long term estrogen deprivation.
The Journal of biological chemistry 2003;278(33):30458-68.
-
2003: Dowsett Mitch; Ashworth Alan
New biology of the oestrogen receptor.
Lancet 2003;362(9380):260-2.
-
2003: Davies Giles; Salter Janine; Hills Margaret; Martin Lesley-Ann; Sacks Nigel; Dowsett Mitch
Correlation between cyclooxygenase-2 expression and angiogenesis in human breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(7):2651-6.
-
2003: Johnston Stephen R D; Hickish Tamas; Ellis Paul; Houston Stephen; Kelland Lloyd; Dowsett Mitch; Salter Janine; Michiels Bart; Perez-Ruixo Juan Jose; Palmer Peter; Howes Angela
Phase II study of the efficacy and tolerability of two dosing regimens of the farnesyl transferase inhibitor, R115777, in advanced breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2003;21(13):2492-9.
-
2003: Smith Ian E; Dowsett Mitch
Aromatase inhibitors in breast cancer.
The New England journal of medicine 2003;348(24):2431-42.
-
2003: Ring Alistair; Dowsett Mitch
Human epidermal growth factor receptor-2 and hormonal therapies: clinical implications.
Clinical breast cancer 2003;4 Suppl 1():S34-41.
-
2003: Dowsett M; Bartlett J; Ellis I O; Salter J; Hills M; Mallon E; Watters A D; Cooke T; Paish C; Wencyk P M; Pinder S E
Correlation between immunohistochemistry (HercepTest) and fluorescence in situ hybridization (FISH) for HER-2 in 426 breast carcinomas from 37 centres.
The Journal of pathology 2003;199(4):418-23.
-
2003: Bilous Michael; Dowsett Mitch; Hanna Wedad; Isola Jorma; Lebeau Annette; Moreno Aberlardo; Penault-Llorca Frédérique; Rüschoff Josef; Tomasic Gorana; van de Vijver Marc
Current perspectives on HER2 testing: a review of national testing guidelines.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2003;16(2):173-82.
-
2003: Johnston Stephen R D; Head Julia; Pancholi Sunil; Detre Simone; Martin Lesley-Ann; Smith Ian E; Dowsett Mitch
Integration of signal transduction inhibitors with endocrine therapy: an approach to overcoming hormone resistance in breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(1 Pt 2):524S-32S.
-
2003: Dowsett Mitch
Preoperative models to evaluate endocrine strategies for breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(1 Pt 2):502S-10S.
-
2003: Come Steven E; Buzdar Aman U; Arteaga Carlos L; Brodie Angela M; Davidson Nancy E; Dowsett Mitch; Ingle James N; Johnston Stephen R D; Lee Adrian V; Osborne C Kent; Pritchard Kathleen I; Vogel Victor G; Winer Eric P; Hart Carol S
Second International Conference on Recent Advances and Future Directions in Endocrine Manipulation of Breast Cancer: summary consensus statement.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(1 Pt 2):443S-6S.
-
2002: Dowsett Mitch; Howell Anthony
Breast cancer: aromatase inhibitors take on tamoxifen.
Nature medicine 2002;8(12):1341-4.
-
2002: Cleator S; Parton M; Dowsett M
The biology of neoadjuvant chemotherapy for breast cancer.
Endocrine-related cancer 2002;9(3):183-95.
-
2002: Chan Christina M W; Martin Lesley-Ann; Johnston Stephen R D; Ali Simak; Dowsett Mitch
Molecular changes associated with the acquisition of oestrogen hypersensitivity in MCF-7 breast cancer cells on long-term oestrogen deprivation.
The Journal of steroid biochemistry and molecular biology 2002;81(4-5):333-41.
-
2002: Harper-Wynne Catherine; Ross Gillian; Sacks Nigel; Salter Janine; Nasiri Nazar; Iqbal Jhangir; A'Hern Roger; Dowsett Mitch
Effects of the aromatase inhibitor letrozole on normal breast epithelial cell proliferation and metabolic indices in postmenopausal women: a pilot study for breast cancer prevention.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2002;11(7):614-21.
-
2002: Davies G; Martin L A; Sacks N; Dowsett M
Cyclooxygenase-2 (COX-2), aromatase and breast cancer: a possible role for COX-2 inhibitors in breast cancer chemoprevention.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2002;13(5):669-78.
-
2002: Assersohn Laura; Gangi Lisa; Zhao Yingdong; Dowsett Mitch; Simon Richard; Powles Trevor J; Liu Edison T
The feasibility of using fine needle aspiration from primary breast cancers for cDNA microarray analyses.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(3):794-801.
-
2002: Geisler Jürgen; Haynes Ben; Anker Gun; Dowsett Mitch; Lønning Per Eystein
Influence of letrozole and anastrozole on total body aromatization and plasma estrogen levels in postmenopausal breast cancer patients evaluated in a randomized, cross-over study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(3):751-7.
-
2002: Di Leo Angelo; Dowsett Mitch; Horten Bruce; Penault-Llorca Frédérique
Current status of HER2 testing.
Oncology 2002;63 Suppl 1():25-32.
-
2002: Sotiriou Christos; Powles Trevor J; Dowsett Mitch; Jazaeri Amir A; Feldman Andrew L; Assersohn Laura; Gadisetti Chandramouli; Libutti Steven K; Liu Edison T
Gene expression profiles derived from fine needle aspiration correlate with response to systemic chemotherapy in breast cancer.
Breast cancer research : BCR 2002;4(3):R3.
-
2002: Simpson Evan R; Dowsett Mitch
Aromatase and its inhibitors: significance for breast cancer therapy.
Recent progress in hormone research 2002;57():317-38.
-
2001: Dowsett M; Harper-Wynne C; Boeddinghaus I; Salter J; Hills M; Dixon M; Ebbs S; Gui G; Sacks N; Smith I
HER-2 amplification impedes the antiproliferative effects of hormone therapy in estrogen receptor-positive primary breast cancer.
Cancer research 2001;61(23):8452-8.
-
2001: Kelland L R; Smith V; Valenti M; Patterson L; Clarke P A; Detre S; End D; Howes A J; Dowsett M; Workman P; Johnston S R
Preclinical antitumor activity and pharmacodynamic studies with the farnesyl protein transferase inhibitor R115777 in human breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(11):3544-50.
-
2001: Dowsett M
Overexpression of HER-2 as a resistance mechanism to hormonal therapy for breast cancer.
Endocrine-related cancer 2001;8(3):191-5.
-
2001: Geisler J; Detre S; Berntsen H; Ottestad L; Lindtjørn B; Dowsett M; Einstein Lønning P
Influence of neoadjuvant anastrozole (Arimidex) on intratumoral estrogen levels and proliferation markers in patients with locally advanced breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(5):1230-6.
-
2001: Harper-Wynne C; Dowsett M
Recent advances in the clinical application of aromatase inhibitors.
The Journal of steroid biochemistry and molecular biology 2001;76(1-5):179-86.
-
2000: Ellis I O; Dowsett M; Bartlett J; Walker R; Cooke T; Gullick W; Gusterson B; Mallon E; Lee P B
Recommendations for HER2 testing in the UK.
Journal of clinical pathology 2000;53(12):890-2.
-
2000: Chang J; Ormerod M; Powles T J; Allred D C; Ashley S E; Dowsett M
Apoptosis and proliferation as predictors of chemotherapy response in patients with breast carcinoma.
Cancer 2000;89(11):2145-52.
-
2000: Zabaglo L; Ormerod M G; Dowsett M
Measurement of markers for breast cancer in a model system using laser scanning cytometry.
Cytometry 2000;41(3):166-71.
-
2000: Dowsett M
Use of risk determinants for different breast cancer prevention strategies.
European journal of cancer (Oxford, England : 1990) 2000;36(10):1283-7.
-
2000: Dowsett M; Dixon J M; Horgan K; Salter J; Hills M; Harvey E
Antiproliferative effects of idoxifene in a placebo-controlled trial in primary human breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(6):2260-7.
-
2000: Chang J; Powles T J; Allred D C; Ashley S E; Makris A; Gregory R K; Osborne C K; Dowsett M
Prediction of clinical outcome from primary tamoxifen by expression of biologic markers in breast cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(2):616-21.
-
2000: Gregory R K; Powles T J; Salter J; Chang J C; Ashley S; Dowsett M
Prognostic relevance of cerbB2 expression following neoadjuvant chemotherapy in patients in a randomised trial of neoadjuvant versus adjuvant chemoendocrine therapy.
Breast cancer research and treatment 2000;59(2):171-5.
-
2000: Dowsett M; Cooke T; Ellis I; Gullick W J; Gusterson B; Mallon E; Walker R
Assessment of HER2 status in breast cancer: why, when and how?
European journal of cancer (Oxford, England : 1990) 2000;36(2):170-6.
-
2000: Dowsett M
New hurdles for translational research.
Breast cancer research : BCR 2000;2(4):241-3.
-
2000: Dowsett M; Donaldson K; Tsuboi M; Wong J; Yates R
Effects of the aromatase inhibitor anastrozole on serum oestrogens in Japanese and Caucasian women.
Cancer chemotherapy and pharmacology 2000;46(1):35-9.
-
1999: Chan C M; Lykkesfeldt A E; Parker M G; Dowsett M
Expression of nuclear receptor interacting proteins TIF-1, SUG-1, receptor interacting protein 140, and corepressor SMRT in tamoxifen-resistant breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(11):3460-7.
-
1999: Chang J; Powles T J; Allred D C; Ashley S E; Clark G M; Makris A; Assersohn L; Gregory R K; Osborne C K; Dowsett M
Biologic markers as predictors of clinical outcome from systemic therapy for primary operable breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1999;17(10):3058-63.
-
1999: Dowsett M; Pfister C; Johnston S R; Miles D W; Houston S J; Verbeek J A; Gundacker H; Sioufi A; Smith I E
Impact of tamoxifen on the pharmacokinetics and endocrine effects of the aromatase inhibitor letrozole in postmenopausal women with breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(9):2338-43.
-
1999: Johnston S R; Boeddinghaus I M; Riddler S; Haynes B P; Hardcastle I R; Rowlands M; Grimshaw R; Jarman M; Dowsett M
Idoxifene antagonizes estradiol-dependent MCF-7 breast cancer xenograft growth through sustained induction of apoptosis.
Cancer research 1999;59(15):3646-51.
-
1999: Dowsett M; Doody D; Miall S; Howes A; English J; Coombes R C
Vorozole results in greater oestrogen suppression than formestane in postmenopausal women and when added to goserelin in premenopausal women with advanced breast cancer.
Breast cancer research and treatment 1999;56(1):25-34.
-
1999: Dowsett M
Drug and hormone interactions of aromatase inhibitors.
Endocrine-related cancer 1999;6(2):181-5.
-
1999: Makris A; Powles T J; Kakolyris S; Dowsett M; Ashley S E; Harris A L
Reduction in angiogenesis after neoadjuvant chemoendocrine therapy in patients with operable breast carcinoma.
Cancer 1999;85(9):1996-2000.
-
1999: Detre S; Salter J; Barnes D M; Riddler S; Hills M; Johnston S R; Gillett C; A'Hern R; Dowsett M
Time-related effects of estrogen withdrawal on proliferation- and cell death-related events in MCF-7 xenografts.
International journal of cancer. Journal international du cancer 1999;81(2):309-13.
-
1999: Dowsett M; Archer C; Assersohn L; Gregory R K; Ellis P A; Salter J; Chang J; Mainwaring P; Boeddinghaus I; Johnston S R; Powles T J; Smith I E
Clinical studies of apoptosis and proliferation in breast cancer.
Endocrine-related cancer 1999;6(1):25-8.
-
1999: Johnston S R; Lu B; Scott G K; Kushner P J; Smith I E; Dowsett M; Benz C C
Increased activator protein-1 DNA binding and c-Jun NH2-terminal kinase activity in human breast tumors with acquired tamoxifen resistance.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(2):251-6.
-
1999: Makris A; Powles T J; Allred D C; Ashley S E; Trott P A; Ormerod M G; Titley J C; Dowsett M
Quantitative changes in cytological molecular markers during primary medical treatment of breast cancer: a pilot study.
Breast cancer research and treatment 1999;53(1):51-9.
-
1999: Dowsett M; Tobias J S; Howell A; Blackman G M; Welch H; King N; Ponzone R; von Euler M; Baum M
The effect of anastrozole on the pharmacokinetics of tamoxifen in post-menopausal women with early breast cancer.
British journal of cancer 1999;79(2):311-5.
-
1998: Geisler J; King N; Anker G; Ornati G; Di Salle E; Lønning P E; Dowsett M
In vivo inhibition of aromatization by exemestane, a novel irreversible aromatase inhibitor, in postmenopausal breast cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(9):2089-93.
-
1998: Dowsett M; Detre S; Ormerod M G; Ellis P A; Mainwaring P N; Titley J C; Smith I E
Analysis and sorting of apoptotic cells from fine-needle aspirates of excised human primary breast carcinomas.
Cytometry 1998;32(4):291-300.
-
1998: Powles T; Eeles R; Ashley S; Easton D; Chang J; Dowsett M; Tidy A; Viggers J; Davey J
Interim analysis of the incidence of breast cancer in the Royal Marsden Hospital tamoxifen randomised chemoprevention trial.
Lancet 1998;352(9122):98-101.
-
1998: Dowsett M
Improved prognosis for biomarkers in breast cancer.
Lancet 1998;351(9118):1753-4.
-
1998: Ellis P A; Smith I E; Detre S; Burton S A; Salter J; A'Hern R; Walsh G; Johnston S R; Dowsett M
Reduced apoptosis and proliferation and increased Bcl-2 in residual breast cancer following preoperative chemotherapy.
Breast cancer research and treatment 1998;48(2):107-16.
-
1998: Chang J; Powles T J; Ashley S E; Iveson T; Gregory R K; Dowsett M
Variation in endometrial thickening in women with amenorrhea on tamoxifen.
Breast cancer research and treatment 1998;48(1):81-5.
-
1998: Makris A; Powles T J; Allred D C; Ashley S; Ormerod M G; Titley J C; Dowsett M
Changes in hormone receptors and proliferation markers in tamoxifen treated breast cancer patients and the relationship with response.
Breast cancer research and treatment 1998;48(1):11-20.
-
1998: Mainwaring P N; Ellis P A; Detre S; Smith I E; Dowsett M
Comparison of in situ methods to assess DNA cleavage in apoptotic cells in patients with breast cancer.
Journal of clinical pathology 1998;51(1):34-7.
-
1998: Lønning P E; Geisler J; Dowsett M
Pharmacological and clinical profile of anastrozole.
Breast cancer research and treatment 1998;49 Suppl 1():S53-7; discussion S73-7.
-
1997: Johnston S R; Lu B; Dowsett M; Liang X; Kaufmann M; Scott G K; Osborne C K; Benz C C
Comparison of estrogen receptor DNA binding in untreated and acquired antiestrogen-resistant human breast tumors.
Cancer research 1997;57(17):3723-7.
-
1997: Chan C M; Dowsett M
A novel estrogen receptor variant mRNA lacking exons 4 to 6 in breast carcinoma.
The Journal of steroid biochemistry and molecular biology 1997;62(5-6):419-30.
-
1997: Ellis P A; Saccani-Jotti G; Clarke R; Johnston S R; Anderson E; Howell A; A'Hern R; Salter J; Detre S; Nicholson R; Robertson J; Smith I E; Dowsett M
Induction of apoptosis by tamoxifen and ICI 182780 in primary breast cancer.
International journal of cancer. Journal international du cancer 1997;72(4):608-13.
-
1997: Zhu X; Daffada A A; Chan C M; Dowsett M
Identification of an exon 3 deletion splice variant androgen receptor mRNA in human breast cancer.
International journal of cancer. Journal international du cancer 1997;72(4):574-80.
-
1997: Dowsett M; Daffada A; Chan C M; Johnston S R
Oestrogen receptor mutants and variants in breast cancer.
European journal of cancer (Oxford, England : 1990) 1997;33(8):1177-83.
-
1997: Detre S; Ormerod M G; Titley J C; Dowsett M
An unusual artefact in the terminal deoxynucleotidyl transferase assay for apoptotic cells.
Cytometry 1997;28(3):264-7.
-
1997: Makris A; Allred D C; Powles T J; Dowsett M; Fernando I N; Trott P A; Ashley S E; Ormerod M G; Titley J C; Osborne C K
Cytological evaluation of biological prognostic markers from primary breast carcinomas.
Breast cancer research and treatment 1997;44(1):65-74.
-
1997: Makris A; Powles T J; Dowsett M; Osborne C K; Trott P A; Fernando I N; Ashley S E; Ormerod M G; Titley J C; Gregory R K; Allred D C
Prediction of response to neoadjuvant chemoendocrine therapy in primary breast carcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(4):593-600.
-
1997: Dowsett M
Future uses for aromatase inhibitors in breast cancer.
The Journal of steroid biochemistry and molecular biology 1997;61(3-6):261-6.
-
1997: Barrie S E; Haynes B P; Potter G A; Chan F C; Goddard P M; Dowsett M; Jarman M
Biochemistry and pharmacokinetics of potent non-steroidal cytochrome P450(17alpha) inhibitors.
The Journal of steroid biochemistry and molecular biology 1997;60(5-6):347-51.
-
1997: Ellis P A; Smith I E; McCarthy K; Detre S; Salter J; Dowsett M
Preoperative chemotherapy induces apoptosis in early breast cancer.
Lancet 1997;349(9055):849.
-
1997: Dowsett M; Lønning P E
Anastrozole--a new generation in aromatase inhibition: clinical pharmacology.
Oncology 1997;54 Suppl 2():11-4.
-
1997: Ellis P A; Lonning P E; Borresen-Dale A; Aas T; Geisler S; Akslen L A; Salter I; Smith I E; Dowsett M
Absence of p21 expression is associated with abnormal p53 in human breast carcinomas.
British journal of cancer 1997;76(4):480-5.
-
1997: Johnston S R; Riddler S; Haynes B P; A'Hern R; Smith I E; Jarman M; Dowsett M
The novel anti-oestrogen idoxifene inhibits the growth of human MCF-7 breast cancer xenografts and reduces the frequency of acquired anti-oestrogen resistance.
British journal of cancer 1997;75(6):804-9.
-
1996: Geisler J; King N; Dowsett M; Ottestad L; Lundgren S; Walton P; Kormeset P O; Lønning P E
Influence of anastrozole (Arimidex), a selective, non-steroidal aromatase inhibitor, on in vivo aromatisation and plasma oestrogen levels in postmenopausal women with breast cancer.
British journal of cancer 1996;74(8):1286-91.
-
1996: Dowsett M; Detre S; Rowlands M; Grimshaw R
Oestrogen formation in breast: clinical and biological importance.
The Journal of endocrinology 1996;150 Suppl():S59-63.
-
1996: Ellis P A; Smith I E; Dowsett M
Apoptosis--its role in tumour growth and therapy.
Cytopathology : official journal of the British Society for Clinical Cytology 1996;7(3):201-3.
-
1996: Dowsett M; Makris A; Ellis P; Johnston S R; Salter J; Detre S; Humphries S; Saccani-Jotti G; Powles T J; Smith I E
Oncogene products and other diagnostic markers in human breast cancer patients. Treatment effects and their significance.
Annals of the New York Academy of Sciences 1996;784():403-11.
-
1996: Ellis P A; Makris A; Burton S A; Titley J; Ormerod M G; Salter J; Powles T J; Smith I E; Dowsett M
Comparison of MIB-1 proliferation index with S-phase fraction in human breast carcinomas.
British journal of cancer 1996;73(5):640-3.
-
1996: Dowsett M; Lee K; Macaulay V M; Detre S; Rowlands M; Grimshaw R
The control and biological importance of intratumoural aromatase in breast cancer.
The Journal of steroid biochemistry and molecular biology 1996;56(1-6 Spec No):145-50.
-
1995: Daffada A A; Dowsett M
Tissue-dependent expression of a novel splice variant of the human oestrogen receptor.
The Journal of steroid biochemistry and molecular biology 1995;55(3-4):413-21.
-
1995: Detre S; Saclani Jotti G; Dowsett M
A "quickscore" method for immunohistochemical semiquantitation: validation for oestrogen receptor in breast carcinomas.
Journal of clinical pathology 1995;48(9):876-8.
-
1995: Johnston S R; Saccani-Jotti G; Smith I E; Salter J; Newby J; Coppen M; Ebbs S R; Dowsett M
Changes in estrogen receptor, progesterone receptor, and pS2 expression in tamoxifen-resistant human breast cancer.
Cancer research 1995;55(15):3331-8.
-
1995: Lee K; Macaulay V M; Nicholls J E; Detre S; Ashworth A; Dowsett M
An in vivo model of intratumoural aromatase using aromatase-transfected MCF7 human breast cancer cells.
International journal of cancer. Journal international du cancer 1995;62(3):297-302.
-
1995: Newby J C; A'Hern R P; Leek R D; Smith I E; Harris A L; Dowsett M
Immunohistochemical assay for epidermal growth factor receptor on paraffin-embedded sections: validation against ligand-binding assay and clinical relevance in breast cancer.
British journal of cancer 1995;71(6):1237-42.
-
1995: Coombes R C; Haynes B P; Dowsett M; Quigley M; English J; Judson I R; Griggs L J; Potter G A; McCague R; Jarman M
Idoxifene: report of a phase I study in patients with metastatic breast cancer.
Cancer research 1995;55(5):1070-4.
-
1995: Dowsett M; Howell R; Salter J; Thomas N M; Thomas E J
Effects of the pure anti-oestrogen ICI 182780 on oestrogen receptors, progesterone receptors and Ki67 antigen in human endometrium in vivo.
Human reproduction (Oxford, England) 1995;10(2):262-7.
-
1995: Daffada A A; Johnston S R; Smith I E; Detre S; King N; Dowsett M
Exon 5 deletion variant estrogen receptor messenger RNA expression in relation to tamoxifen resistance and progesterone receptor/pS2 status in human breast cancer.
Cancer research 1995;55(2):288-93.
-
1995: MacNeill F A; Jacobs S; Dowsett M; Lonning P E; Powles T J
The effects of oral 4-hydroxyandrostenedione on peripheral aromatisation in post-menopausal breast cancer patients.
Cancer chemotherapy and pharmacology 1995;36(3):249-54.
-
1995: Fernando I N; Powles T J; Dowsett M; Ashley S; McRobert L; Titley J; Ormerod M G; Sacks N; Nicolson M C; Nash A
Determining factors which predict response to primary medical therapy in breast cancer using a single fine needle aspirate with immunocytochemical staining and flow cytometry.
Virchows Archiv : an international journal of pathology 1995;426(2):155-61.
-
1994: Fernando I N; Titley J C; Powles T J; Dowsett M; Trott P A; Ashley S E; Ford H T; Ormerod M G
Measurement of S-phase fraction and ploidy in sequential fine-needle aspirates from primary human breast tumours treated with tamoxifen.
British journal of cancer 1994;70(6):1211-6.
-
1994: Daffada A A; Johnston S R; Nicholls J; Dowsett M
Detection of wild type and exon 5-deleted splice variant oestrogen receptor (ER) mRNA in ER-positive and -negative breast cancer cell lines by reverse transcription/polymerase chain reaction.
Journal of molecular endocrinology 1994;13(3):265-73.
-
1994: Burton S A; Dowsett M; Trott P A
Comparison of two methods of storing breast fine needle aspirates (FNAs) using oestrogen receptor immunocytochemical assay as a method of evaluating the storage methods.
Cytopathology : official journal of the British Society for Clinical Cytology 1994;5(6):380-3.
-
1994: Thomas E J; Walton P L; Thomas N M; Dowsett M
The effects of ICI 182,780, a pure anti-oestrogen, on the hypothalamic-pituitary-gonadal axis and on endometrial proliferation in pre-menopausal women.
Human reproduction (Oxford, England) 1994;9(11):1991-6.
-
1994: Saccani Jotti G; Johnston S R; Salter J; Detre S; Dowsett M
Comparison of new immunohistochemical assay for oestrogen receptor in paraffin wax embedded breast carcinoma tissue with quantitative enzyme immunoassay.
Journal of clinical pathology 1994;47(10):900-5.
-
1994: Barrie S E; Potter G A; Goddard P M; Haynes B P; Dowsett M; Jarman M
Pharmacology of novel steroidal inhibitors of cytochrome P450(17) alpha (17 alpha-hydroxylase/C17-20 lyase).
The Journal of steroid biochemistry and molecular biology 1994;50(5-6):267-73.
-
1994: MacNeill F A; Jacobs S; Lønning P E; Powles T J; Dowsett M
Combined treatment with 4-hydroxyandrostenedione and aminoglutethimide: effects on aromatase inhibition and oestrogen suppression.
British journal of cancer 1994;69(6):1171-5.
-
1994: Detre S; King N; Salter J; MacLennan K; McKinna J A; Dowsett M
Immunohistochemical and biochemical analysis of the oestrogen regulated protein pS2, and its relation with oestrogen receptor and progesterone receptor in breast cancer.
Journal of clinical pathology 1994;47(3):240-4.
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1994: Macaulay V M; Nicholls J E; Gledhill J; Rowlands M G; Dowsett M; Ashworth A
Biological effects of stable overexpression of aromatase in human hormone-dependent breast cancer cells.
British journal of cancer 1994;69(1):77-83.
-
1994: O'Brien M E; Dowsett M; Fryatt I; Wiltshaw E
Steroid hormone profile in postmenopausal women with ovarian cancer.
European journal of cancer (Oxford, England : 1990) 1994;30A(4):442-5.
-
1994: Dowsett M
Aromatase inhibition: basic concepts, and the pharmacodynamics of formestane.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1994;5 Suppl 7():S3-5.
-
1994: Johnston S R; MacLennan K A; Sacks N P; Salter J; Smith I E; Dowsett M
Modulation of Bcl-2 and Ki-67 expression in oestrogen receptor-positive human breast cancer by tamoxifen.
European journal of cancer (Oxford, England : 1990) 1994;30A(11):1663-9.
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1993: Johnston S R; Haynes B P; Sacks N P; McKinna J A; Griggs L J; Jarman M; Baum M; Smith I E; Dowsett M
Effect of oestrogen receptor status and time on the intra-tumoural accumulation of tamoxifen and N-desmethyltamoxifen following short-term therapy in human primary breast cancer.
Breast cancer research and treatment 1993;28(3):241-50.
-
1993: Johnston S R; Haynes B P; Smith I E; Jarman M; Sacks N P; Ebbs S R; Dowsett M
Acquired tamoxifen resistance in human breast cancer and reduced intra-tumoral drug concentration.
Lancet 1993;342(8886-8887):1521-2.
-
1993: Pearce S; Bassendine M; Dowsett M
Sex hormone binding globulin and non-protein-bound oestradiol in postmenopausal patients with primary biliary cirrhosis and normal controls.
The Journal of steroid biochemistry and molecular biology 1993;44(3):273-6.
-
1993: Dowsett M; Macaulay V; Gledhill J; Ryde C; Nicholls J; Ashworth A; McKinna J A; Smith I E
Control of aromatase in breast cancer cells and its importance for tumor growth.
The Journal of steroid biochemistry and molecular biology 1993;44(4-6):605-9.
-
1993: Coombes R C; Jarman M; Dowsett M; Chander S K; Rowlands M G; Di Salle E; Evans T J
New endocrine agents for the treatment of breast cancer.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1993;127():267-75.
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1992: MacNeill F A; Jones A L; Jacobs S; Lønning P E; Powles T J; Dowsett M
The influence of aminoglutethimide and its analogue rogletimide on peripheral aromatisation in breast cancer.
British journal of cancer 1992;66(4):692-7.
-
1992: Newton C J; Butta A; Nicholls J; Dowsett M
Oestradiol synthesis from oestrone in malignant breast epithelial cells: studies on a high affinity, 80 kDa form of oestradiol dehydrogenase.
The Journal of steroid biochemistry and molecular biology 1992;42(8):891-900.
-
1992: Dowsett M; Stein R C; Coombes R C
Aromatization inhibition alone or in combination with GnRH agonists for the treatment of premenopausal breast cancer patients.
The Journal of steroid biochemistry and molecular biology 1992;43(1-3):155-9.
-
1992: Davies J H; Dowsett M; Jacobs S; Coombes R C; Hedley A; Shearer R J
Aromatase inhibition: 4-hydroxyandrostenedione (4-OHA, CGP 32349) in advanced prostatic cancer.
British journal of cancer 1992;66(1):139-42.
-
1992: Johnston S R; Dowsett M; Smith I E
Towards a molecular basis for tamoxifen resistance in breast cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1992;3(7):503-11.
-
1992: Jacobs S; MacNeill F; Lonning P; Dowsett M; Jones A; Powles T
Aromatase activity, serum oestradiol and their correlation with demographic indices.
The Journal of steroid biochemistry and molecular biology 1992;41(3-8):769-71.
-
1992: Ryde C M; Nicholls J E; Dowsett M
Steroid and growth factor modulation of aromatase activity in MCF7 and T47D breast carcinoma cell lines.
Cancer research 1992;52(6):1411-5.
-
1992: Dowsett M; Jacobs S; Aherne J; Smith I E
Clinical and endocrine effects of leuprorelin acetate in pre- and postmenopausal patients with advanced breast cancer.
Clinical therapeutics 1992;14 Suppl A():97-103.
-
1992: Dowsett M; Mehta A; King N; Smith I E; Powles T J; Stein R C; Coombes R C
An endocrine and pharmacokinetic study of four oral doses of formestane in postmenopausal breast cancer patients.
European journal of cancer (Oxford, England : 1990) 1992;28(2-3):415-20.
-
1992: Ryde C M; Smith D; King N; Trott P A; MacLennan K; McKinna J A; Minasian H; Dowsett M
Comparison of four immunochemical methods for the measurement of oestrogen receptor levels in breast cancer.
Cytopathology : official journal of the British Society for Clinical Cytology 1992;3(3):155-60.
-
1992: Lønning P E; Dowsett M; Jones A; Ekse D; Jacobs S; McNeil F; Johannessen D C; Powles T J
Influence of aminoglutethimide on plasma oestrogen levels in breast cancer patients on 4-hydroxyandrostenedione treatment.
Breast cancer research and treatment 1992;23(1-2):57-62.
-
1992: Coombes R C; Hughes S W; Dowsett M
4-hydroxyandrostenedione: a new treatment for postmenopausal patients with breast cancer.
European journal of cancer (Oxford, England : 1990) 1992;28A(12):1941-5.
-
1992: Jones A L; MacNeill F; Jacobs S; Lonning P E; Dowsett M; Powles T J
The influence of intramuscular 4-hydroxyandrostenedione on peripheral aromatisation in breast cancer patients.
European journal of cancer (Oxford, England : 1990) 1992;28A(10):1712-6.
-
1992: Davies J H; Shearer R J; Rowlands M G; Poon G K; Houghton J; Jarman M; Dowsett M
Effects of 4-hydroxyandrost-4-ene-3,17-dione and its metabolites on 5 alpha-reductase activity and the androgen receptor.
Journal of enzyme inhibition 1992;6(2):141-7.
-
1991: Dowsett M
Inhibitors of steroidogenic enzymes for the treatment of breast cancer.
The Journal of steroid biochemistry and molecular biology 1991;39(5B):805-9.
-
1991: Dowsett M; MacNeill F; Mehta A; Newton C; Haynes B; Jones A; Jarman M; Lonning P; Powles T J; Coombes R C
Endocrine, pharmacokinetic and clinical studies of the aromatase inhibitor 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione ('pyridoglutethimide') in postmenopausal breast cancer patients.
British journal of cancer 1991;64(5):887-94.
-
1991: Newton C J; Mehta A; Dowsett M
The effect of the aromatase inhibitor, rogletimide (pyridoglutethimide), on guinea pig adrenal cell steroidogenesis and placental microsomal aromatase activity: comparison with aminoglutethimide and CGS 16949A.
The Journal of steroid biochemistry and molecular biology 1991;39(5A):723-7.
-
1991: Poon G K; Jarman M; Rowlands M G; Dowsett M; Firth J
Determination of 4-hydroxyandrost-4-ene-3,17-dione metabolism in breast cancer patients using high-performance liquid chromatography-mass spectrometry.
Journal of chromatography 1991;565(1-2):75-88.
-
1991: Dowsett M; Richner J
Effects of cytotoxic chemotherapy on ovarian and adrenal steroidogenesis in pre-menopausal breast cancer patients.
Oncology 1991;48(3):215-20.
-
1991: Haynes B P; Jarman M; Dowsett M; Mehta A; Lønning P E; Griggs L J; Jones A; Powles T; Stein R; Coombes R C
Pharmacokinetics and pharmacodynamics of the aromatase inhibitor 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione in patients with postmenopausal breast cancer.
Cancer chemotherapy and pharmacology 1991;27(5):367-72.
-
1991: Rowlands M G; Davies J H; Shearer R J; Dowsett M
Comparison of aromatase activity in human prostatic, testicular and placental tissues.
Journal of enzyme inhibition 1991;4(4):307-13.
-
1991: Jacobs S; Lønning P E; Haynes B; Griggs L; Dowsett M
Measurement of aromatisation by a urine technique suitable for the evaluation of aromatase inhibitors in vivo.
Journal of enzyme inhibition 1991;4(4):315-25.
-
1991: Dowsett M; Mehta A; Cantwell B M; Harris A L
Low-dose aminoglutethimide in postmenopausal breast cancer: effects on adrenal and thyroid hormone secretion.
European journal of cancer (Oxford, England : 1990) 1991;27(7):846-9.
-
1990: Dowsett M
Clinical development of aromatase inhibitors for the treatment of breast and prostate cancer.
The Journal of steroid biochemistry and molecular biology 1990;37(6):1037-41.
-
1990: Dowsett M; Mehta A; Mansi J; Smith I E
A dose-comparative endocrine-clinical study of leuprorelin in premenopausal breast cancer patients.
British journal of cancer 1990;62(5):834-7.
-
1990: Stein R C; Dowsett M; Hedley A; Gazet J C; Ford H T; Coombes R C
The clinical and endocrine effects of 4-hydroxyandrostenedione alone and in combination with goserelin in premenopausal women with advanced breast cancer.
British journal of cancer 1990;62(4):679-83.
-
1990: Shearer R J; Davies J H; Dowsett M; Malone P R; Hedley A; Cunningham D; Coombes R C
Aromatase inhibition in advanced prostatic cancer: preliminary communication.
British journal of cancer 1990;62(2):275-6.
-
1990: Dowsett M; Stein R C; Mehta A; Coombes R C
Potency and selectivity of the non-steroidal aromatase inhibitor CGS 16949A in postmenopausal breast cancer patients.
Clinical endocrinology 1990;32(5):623-34.
-
1990: Stein R C; Dowsett M; Cunningham D C; Davenport J; Ford H T; Gazet J C; von Angerer E; Coombes R C
Phase I/II study of the anti-oestrogen zindoxifene (D16726) in the treatment of advanced breast cancer. A Cancer Research Campaign Phase I/II Clinical Trials Committee study.
British journal of cancer 1990;61(3):451-3.
-
1990: Stein R C; Dowsett M; Davenport J; Hedley A; Ford H T; Gazet J C; Coombes R C
Preliminary study of the treatment of advanced breast cancer in postmenopausal women with the aromatase inhibitor CGS 16949A.
Cancer research 1990;50(5):1381-4.
-
1990: Stein R C; Dowsett M; Hedley A; Davenport J; Gazet J C; Ford H T; Coombes R C
Treatment of advanced breast cancer in postmenopausal women with 4-hydroxyandrostenedione.
Cancer chemotherapy and pharmacology 1990;26(1):75-8.
-
1990: Dowsett M; Lloyd P
Comparison of the pharmacokinetics and pharmacodynamics of unformulated and formulated 4-hydroxyandrostenedione taken orally by healthy men.
Cancer chemotherapy and pharmacology 1990;27(1):67-71.
-
1990: Dowsett M
Novel approaches to the endocrine therapy of breast cancer.
European journal of cancer (Oxford, England : 1990) 1990;26(9):989-92.
-
1989: Powles T J; Hardy J R; Ashley S E; Cosgrove D; Davey J B; Dowsett M; McKinna A; Nash A G; Rundle S K; Sinnett H D
Chemoprevention of breast cancer.
Breast cancer research and treatment 1989;14(1):23-31.
-
1989: Powles T J; Hardy J R; Ashley S E; Farrington G M; Cosgrove D; Davey J B; Dowsett M; McKinna J A; Nash A G; Sinnett H D
A pilot trial to evaluate the acute toxicity and feasibility of tamoxifen for prevention of breast cancer.
British journal of cancer 1989;60(1):126-31.
-
1989: Pearce S; Dowsett M; Jeffcoate S L
Three methods compared for estimating the fraction of testosterone and estradiol not bound to sex-hormone-binding globulin.
Clinical chemistry 1989;35(4):632-5.
-
1989: Dowsett M; Cunningham D C; Stein R C; Evans S; Dehennin L; Hedley A; Coombes R C
Dose-related endocrine effects and pharmacokinetics of oral and intramuscular 4-hydroxyandrostenedione in postmenopausal breast cancer patients.
Cancer research 1989;49(5):1306-12.
-
1989: Dowsett M; Cantwell B M; Harris A L
Endocrinology of Zoladex in postmenopausal women.
Hormone research 1989;32 Suppl 1():209-12.
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