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John Drach

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Chengwei Li; Mark Prichard; Debra C Quenelle; John C Drach; Jiri Zemlicka
Synthesis and antiviral activity of 6-deoxycyclopropavir, a new prodrug of cyclopropavir.
Valeria M Zakharova; Larryn W Peterson; Michaela Serpi; Katherine Z Borysko; Julie M Breitenbach; Mindy Collins; John C Drach; John M Hilfinger; Boris A Kashemirov; Ivan S Krylov; Charles E McKenna
Tyrosine-based 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine and -adenine ((S)-HPMPC and (S)-HPMPA) prodrugs: synthesis, stability, antiviral activity, and in vivo transport studies.
Larryn W Peterson; Stefanie Mitchell; Kathy Borysko; Julie M Breitenbach; John C Drach; John M Hilfinger; Boris A Kashemirov; Paul Kijek; Jae-Seung Kim; Charles E McKenna
Synthesis, transport and antiviral activity of Ala-Ser and Val-Ser prodrugs of cidofovir.

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All Publications

2012: Chengwei Li; Mark Prichard; Debra C Quenelle; John C Drach; Jiri Zemlicka
Synthesis and antiviral activity of 6-deoxycyclopropavir, a new prodrug of cyclopropavir.
Bioorganic & medicinal chemistry 2012;20(8):2669-74.
2011: Valeria M Zakharova; Larryn W Peterson; Michaela Serpi; Katherine Z Borysko; Julie M Breitenbach; Mindy Collins; John C Drach; John M Hilfinger; Boris A Kashemirov; Ivan S Krylov; Charles E McKenna
Tyrosine-based 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine and -adenine ((S)-HPMPC and (S)-HPMPA) prodrugs: synthesis, stability, antiviral activity, and in vivo transport studies.
Journal of medicinal chemistry 2011;54(16):5680-93.
2011: Larryn W Peterson; Stefanie Mitchell; Kathy Borysko; Julie M Breitenbach; John C Drach; John M Hilfinger; Boris A Kashemirov; Paul Kijek; Jae-Seung Kim; Charles E McKenna
Synthesis, transport and antiviral activity of Ala-Ser and Val-Ser prodrugs of cidofovir.
Bioorganic & medicinal chemistry letters 2011;21(13):4045-9.
2011: Mark Prichard; Samuel L Frederick; Shannon L Daily; Katherine Z Borysko; Leroy B Townsend; John C Drach; Earl R Kern
Benzimidazole analogs inhibit human herpesvirus 6.
Antimicrobial agents and chemotherapy 2011;55(5):2442-5.
2011: Brian G Gentry; Sara N Gentry; Trachette L Jackson; Jiri Zemlicka; John C Drach
Phosphorylation of antiviral and endogenous nucleotides to di- and triphosphates by guanosine monophosphate kinase.
Biochemical pharmacology 2011;81(1):43-9.
2010: Brian G Gentry; Jeremy P Kamil; Donald M Coen; Jiri Zemlicka; John C Drach
Stereoselective phosphorylation of cyclopropavir by pUL97 and competitive inhibition by maribavir.
Antimicrobial agents and chemotherapy 2010;54(8):3093-8.
2010: Roger G Ptak; Brian G Gentry; Tracy L Hartman; Karen M Watson; M Clayton Osterling; Robert W Buckheit; Leroy B Townsend; John C Drach
Inhibition of human immunodeficiency virus type 1 by triciribine involves the accessory protein nef.
Antimicrobial agents and chemotherapy 2010;54(4):1512-9.
2009: Chengwei Li; Brian G Gentry; John C Drach; Jiri Zemlicka
Synthesis and enantioselectivity of cyclopropavir phosphates for cellular GMP kinase.
Nucleosides, nucleotides & nucleic acids 2009;28(9):795-808.
2009: Santosh B Mhaske; Bashar Ksebati; Mark Prichard; John C Drach; Jiri Zemlicka
Phosphonate analogues of cyclopropavir phosphates and their E-isomers. Synthesis and antiviral activity.
Bioorganic & medicinal chemistry 2009;17(11):3892-9.
2009: Shaoman Zhou; John C Drach; Mark Prichard; Jiri Zemlicka
(Z)- and (E)-2-(1,2-dihydroxyethyl)methylenecyclopropane analogues of 2'-deoxyadenosine and 2'-deoxyguanosine. Synthesis of all stereoisomers, absolute configuration, and antiviral activity.
Journal of medicinal chemistry 2009;52(10):3397-407.
2009: Zhimeng Wu; John C Drach; Mark Prichard; Milka Yanachkova; Ivan Yanachkov; Terry L Bowlin; Jiri Zemlicka
L-valine ester of cyclopropavir: a new antiviral prodrug.
Antiviral chemistry & chemotherapy 2009;20(1):37-46.
2008: Ulrika Eriksson; Larryn W Peterson; Boris A Kashemirov; John M Hilfinger; John C Drach; Katherine Z Borysko; Julie M Breitenbach; Jae Seung Kim; Stefanie Mitchell; Paul Kijek; Charles E McKenna
Serine peptide phosphoester prodrugs of cyclic cidofovir: synthesis, transport, and antiviral activity.
Molecular pharmaceutics 2008;5(4):598-609.
2008: Chengwei Li; Mark Prichard; Brent E Korba; John C Drach; Jiri Zemlicka
Fluorinated methylenecyclopropane analogues of nucleosides. Synthesis and antiviral activity of (Z)- and (E)-9-{[(2-fluoromethyl-2-hydroxymethyl)-cyclopropylidene]methyl}adenine and -guanine.
Bioorganic & medicinal chemistry 2008;16(5):2148-55.
2008: Tun-Cheng Chien; John C Drach; Leroy B Townsend
Design and synthesis of 1-(beta-D-ribofuranosyl)imidazo[4,5-c]pyrazoles as 5:5 bicyclic analogs of purine nucleosides.
Nucleic acids symposium series (2004) 2008;(52):593-4.
2007: Ulrika Eriksson; John M Hilfinger; Jae-Seung Kim; Stefanie Mitchell; Paul Kijek; Katherine Z Borysko; Julie M Breitenbach; John C Drach; Boris A Kashemirov; Charles E McKenna
Synthesis and biological activation of an ethylene glycol-linked amino acid conjugate of cyclic cidofovir.
Bioorganic & medicinal chemistry letters 2007;17(3):583-6.
2007: Shaoman Zhou; Jiri Zemlicka; Earl R Kern; John C Drach
Fluoroanalogues of anti-cytomegalovirus agent cyclopropavir: synthesis and antiviral activity of (E)- and (Z)-9-{[2,2-bis(hydroxymethyl)-3-fluorocyclopropylidene]methyl}-adenines and guanines.
Nucleosides, nucleotides & nucleic acids 2007;26(3):231-43.
2006: Shaoman Zhou; Earl R Kern; Elizabeth Gullen; Yung-Chi Cheng; John C Drach; Sadahiro Tamiya; Hiroaki Mitsuya; Jiri Zemlicka
9-{[3-fluoro-2-(hydroxymethyl)cyclopropylidene]methyl}adenines and -guanines. Synthesis and antiviral activity of all stereoisomers1.
Journal of medicinal chemistry 2006;49(20):6120-8.
2006: Gregory B Less; Nathan W Ockwig; Paul G Rasmussen; Gary D Smith; Laura M Keller; John C Drach
Vanadium complex of 2-(2'-Pyridyl)-4,5-dicyanoimidazole showing spermicidal and cytotoxic properties.
Inorganic chemistry 2006;45(18):7105-10.
2006: Philip L Lorenzi; Christopher P Landowski; Andrea Brancale; Xueqin Song; Leroy B Townsend; John C Drach; Gordon L Amidon
N-methylpurine DNA glycosylase and 8-oxoguanine dna glycosylase metabolize the antiviral nucleoside 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(6):1070-7.
2006: Xinrong Qin; Xinchao Chen; Kun Wang; Lisa Anne Polin ; Earl R Kern; John C Drach; Elizabeth Gullen; Yung-Chi Cheng; Jiri Zemlicka
Synthesis, antiviral, and antitumor activity of 2-substituted purine methylenecyclopropane analogues of nucleosides.
Bioorganic & medicinal chemistry 2006;14(4):1247-54.
2006: Ho-Chul Shin; Jin-Suk Kim; Balvinder S Vig; Xueqin Song; John C Drach; Gordon L Amidon
Interaction of intestinal nucleoside transporter hCNT2 with amino acid ester prodrugs of floxuridine and 2-bromo-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole.
Biological & pharmaceutical bulletin 2006;29(2):247-52.
2006: Mark Prichard; Debra C Quenelle; Deborah J Bidanset; Gloria Komazin; Sunwen Chou; John C Drach; Earl R Kern
Human cytomegalovirus UL27 is not required for viral replication in human tissue implanted in SCID mice.
Virology journal 2006;3():18.
2005: Philip L Lorenzi; Christopher P Landowski; Xueqin Song; Katherine Z Borysko; Julie M Breitenbach; Jae Seung Kim; John M Hilfinger; Leroy B Townsend; John C Drach; Gordon L Amidon
Amino acid ester prodrugs of 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole enhance metabolic stability in vitro and in vivo.
The Journal of pharmacology and experimental therapeutics 2005;314(2):883-90.
2005: Michael T Migawa; John C Drach; Leroy B Townsend
Design, synthesis and antiviral activity of novel 4,5-disubstituted 7-(beta-D-ribofuranosyl)pyrrolo[2,3-d][1,2,3]triazines and the novel 3-amino-5-methyl-1-(beta-D-ribofuranosyl)- and 3-amino-5-methyl-1-(2-deoxy-beta-D-ribofuranosyl)-1,5-dihydro-1,4,5,6,7,8-hexaazaacenaphthylene as analogues of triciribine.
Journal of medicinal chemistry 2005;48(11):3840-51.
2005: Xueqin Song; Balvinder S Vig; Philip L Lorenzi; John C Drach; Leroy B Townsend; Gordon L Amidon
Amino acid ester prodrugs of the antiviral agent 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole as potential substrates of hPEPT1 transporter.
Journal of medicinal chemistry 2005;48(4):1274-7.
2005: Zhaohua Yan; Earl R Kern; Elizabeth Gullen; Yung-Chi Cheng; John C Drach; Jiri Zemlicka
Nucleotides and pronucleotides of 2,2-bis(hydroxymethyl)methylenecyclopropane analogues of purine nucleosides: synthesis and antiviral activity.
Journal of medicinal chemistry 2005;48(1):91-9.
2005: Tun-Cheng Chien; David A Berry; John C Drach; Leroy B Townsend
Synthesis of 3-aminoimidazo[4,5-c]pyrazole nucleoside via the N-N bond formation strategy as a [5:5] fused analog of adenosine.
Nucleosides, nucleotides & nucleic acids 2005;24(10-12):1971-96.
2005: Amalraj Ambrose; Jiri Zemlicka; Earl R Kern; John C Drach; Elizabeth Gullen; Yung-Chi Cheng
Phosphoralaninate pronucleotides of pyrimidine methylenecyclopropane analogues of nucleosides: synthesis and antiviral activity.
Nucleosides, nucleotides & nucleic acids 2005;24(10-12):1763-74.
2005: John D Williams; John C Drach; Leroy B Townsend
Synthesis and antiviral activity of some 2-substituted 3-formyl- and 3-cyano-5,6-dichloroindole nucleosides.
Nucleosides, nucleotides & nucleic acids 2005;24(10-12):1613-26.
2005: Jiong J Chen; Yuan Wei; John D Williams; John C Drach; Leroy B Townsend
Design, synthesis, and antiviral evaluation of some polyhalogenated indole C-nucleosides.
Nucleosides, nucleotides & nucleic acids 2005;24(10-12):1417-37.
2004: Shaoman Zhou; Earl R Kern; Elizabeth Gullen; Yung-Chi Cheng; John C Drach; Shintaro Matsumi; Hiroaki Mitsuya; Jiri Zemlicka
(Z)- and (E)-[2-Fluoro-2-(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines, a new class of methylenecyclopropane analogues of nucleosides: synthesis and antiviral activity.
Journal of medicinal chemistry 2004;47(27):6964-72.
2004: John D Williams; Roger G Ptak; John C Drach; Leroy B Townsend
Synthesis, antiviral activity, and mode of action of some 3-substituted 2,5,6-trichloroindole 2'- and 5'-deoxyribonucleosides.
Journal of medicinal chemistry 2004;47(23):5773-82.
2004: John D Williams; Jiong J Chen; John C Drach; Leroy B Townsend
Synthesis and antiviral activity of 3-formyl- and 3-cyano-2,5,6-trichloroindole nucleoside derivatives.
Journal of medicinal chemistry 2004;47(23):5766-72.
2004: John D Williams; Jiong J Chen; John C Drach; Leroy B Townsend
Design, synthesis, and antiviral activity of certain 3-substituted 2,5,6-trichloroindole nucleosides.
Journal of medicinal chemistry 2004;47(23):5753-65.
2004: Tun-Cheng Chien; Sunita S Saluja; John C Drach; Leroy B Townsend
Synthesis and antiviral evaluation of polyhalogenated imidazole nucleosides: dimensional analogues of 2,5,6-trichloro-1-(beta-D-ribofuranosyl)benzimidazole.
Journal of medicinal chemistry 2004;47(23):5743-52.
2004: David L Evers; Gloria Komazin; Roger G Ptak; Dongjin Shin; Brian T Emmer; Leroy B Townsend; John C Drach
Inhibition of human cytomegalovirus replication by benzimidazole nucleosides involves three distinct mechanisms.
Antimicrobial agents and chemotherapy 2004;48(10):3918-27.
2004: John D Williams; John C Drach; Leroy B Townsend
Synthesis and antiviral evaluation of some novel tricyclic pyrazolo[3,4-b]indole nucleosides.
Nucleosides, nucleotides & nucleic acids 2004;23(5):805-12.
2004: Earl R Kern; Caroll B Hartline; Rachel J Rybak; John C Drach; Leroy B Townsend; Karen K Biron; Deborah J Bidanset
Activities of benzimidazole D- and L-ribonucleosides in animal models of cytomegalovirus infections.
Antimicrobial agents and chemotherapy 2004;48(5):1749-55.
2004: Mark Richard Underwood; Robert G Ferris; Dean W Selleseth; Michelle G Davis; John C Drach; Leroy B Townsend; Karen K Biron; F Leslie Boyd
Mechanism of action of the ribopyranoside benzimidazole GW275175X against human cytomegalovirus.
Antimicrobial agents and chemotherapy 2004;48(5):1647-51.
2004: Shaoman Zhou; Julie M Breitenbach; Katherine Z Borysko; John C Drach; Earl R Kern; Elizabeth Gullen; Yung-Chi Cheng; Jiri Zemlicka
Synthesis and antiviral activity of (Z)- and (E)-2,2-[bis(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines: second-generation methylenecyclopropane analogues of nucleosides.
Journal of medicinal chemistry 2004;47(3):566-75.
2004: Gloria Komazin; Leroy B Townsend; John C Drach
Role of a mutation in human cytomegalovirus gene UL104 in resistance to benzimidazole ribonucleosides.
Journal of virology 2004;78(2):710-5.
2003: Anthony R Porcari; Roger G Ptak; Katherine Z Borysko; Julie M Breitenbach; John C Drach; Leroy B Townsend
Synthesis and antiviral activity of 2-substituted analogs of triciribine.
Nucleosides, nucleotides & nucleic acids 2003;22(12):2171-93.
2003: Gloria Komazin; Roger G Ptak; Brian T Emmer; Leroy B Townsend; John C Drach
Resistance of human cytomegalovirus to the benzimidazole L-ribonucleoside maribavir maps to UL27.
Journal of virology 2003;77(21):11499-506.
2003: John D Williams; Alaa E Mourad; John C Drach; Leroy B Townsend
Design and synthesis of acyclic nucleoside analogs with chlorinated imidazo[1,2-a]pyridine bases.
Nucleosides, nucleotides & nucleic acids 2003;22(10):1907-17.
2003: Ho-Chul Shin; Christopher P Landowski; Duxin Sun; Balvinder S Vig; Insook Kim; Sachin Mittal; Majella Lane; Gus R Rosania; John C Drach; Gordon L Amidon
Functional expression and characterization of a sodium-dependent nucleoside transporter hCNT2 cloned from human duodenum.
Biochemical and biophysical research communications 2003;307(3):696-703.
2003: Stephanie L Williams; Caroll B Hartline; Nicole L Kushner; Emma A Harden; Deborah J Bidanset; John C Drach; Leroy B Townsend; Mark Richard Underwood; Karen K Biron; Earl R Kern
In vitro activities of benzimidazole D- and L-ribonucleosides against herpesviruses.
Antimicrobial agents and chemotherapy 2003;47(7):2186-92.
2003: Kerby Shedden; Leroy B Townsend; John C Drach; Gus R Rosania
A rational approach to personalized anticancer therapy: chemoinformatic analysis reveals mechanistic gene-drug associations.
Pharmaceutical research 2003;20(6):843-7.
2003: Jiong J Chen; John C Drach; Leroy B Townsend
Convergent synthesis of polyhalogenated quinoline C-nucleosides as potential antiviral agents.
The Journal of organic chemistry 2003;68(11):4170-8.
2003: Gloria Komazin; Roger G Ptak; Brian T Emmer; Leroy B Townsend; John C Drach
Resistance of human cytomegalovirus to D- and L-ribosyl benzimidazoles as a tool to identify potential targets for antiviral drugs.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1725-7.
2003: Ruifang Wang; Xinchao Chen; John C Drach; Earl R Kern; Jiri Zemlicka
Synthesis and biological activity of 2-aminopurine methylenecyclopropane analogues of nucleosides.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):813-5.
2003: Xinchao Chen; Earl R Kern; John C Drach; Elizabeth Gullen; Yung-Chi Cheng; Jiri Zemlicka
Structure-activity relationships of (S,Z)-2-aminopurine methylenecyclopropane analogues of nucleosides. Variation of purine-6 substituents and activity against herpesviruses and hepatitis B virus.
Journal of medicinal chemistry 2003;46(8):1531-7.
2003: Kristjan S Gudmundsson; John D Williams; John C Drach; Leroy B Townsend
Synthesis and antiviral activity of novel erythrofuranosyl imidazo[1,2-a]pyridine C-nucleosides constructed via palladium coupling of iodoimidazo[1,2-a]pyridines and dihydrofuran.
Journal of medicinal chemistry 2003;46(8):1449-55.
2003: Ruifang Wang; Xinchao Chen; John C Drach; Earl R Kern; Jiri Zemlicka
Synthesis and biological activity of 2-aminopurine methylenecyclopropane analogues of nucleosides.
Nucleosides, nucleotides & nucleic acids 2003;22(2):135-44.
2002: David L Evers; Gloria Komazin; Dongjin Shin; Debbie D Hwang; Leroy B Townsend; John C Drach
Interactions among antiviral drugs acting late in the replication cycle of human cytomegalovirus.
Antiviral research 2002;56(1):61-72.
2002: Ruifang Wang; Thomas H Corbett; Yung-Chi Cheng; John C Drach; Earl R Kern; Hiroaki Mitsuya; Jiri Zemlicka
Tryptophanyl phosphoramidates as prodrugs of synadenol and its E-isomer: synthesis and biological activity.
Bioorganic & medicinal chemistry letters 2002;12(17):2467-70.
2002: David L Evers; Julie M Breitenbach; Katherine Z Borysko; Leroy B Townsend; John C Drach
Inhibition of cyclin-dependent kinase 1 by purines and pyrrolo[2,3-d]pyrimidines does not correlate with antiviral activity.
Antimicrobial agents and chemotherapy 2002;46(8):2470-6.
2002: George W Koszalka; Nelson W Johnson; Steven S Good; Leslie Boyd; Stanley C Chamberlain; Leroy B Townsend; John C Drach; Karen K Biron
Preclinical and toxicology studies of 1263W94, a potent and selective inhibitor of human cytomegalovirus replication.
Antimicrobial agents and chemotherapy 2002;46(8):2373-80.
2002: Karen K Biron; Robert J Harvey; Stanley C Chamberlain; Steven S Good; Albert A Smith; Michelle G Davis; Christine L Talarico; Wayne H Miller; Robert G Ferris; Ronna E Dornsife; Sylvia C Stanat; John C Drach; Leroy B Townsend; George W Koszalka
Potent and selective inhibition of human cytomegalovirus replication by 1263W94, a benzimidazole L-riboside with a unique mode of action.
Antimicrobial agents and chemotherapy 2002;46(8):2365-72.
2002: Paula M Krosky; Katherine Z Borysko; M Reza Nassiri; Rodrigo V Devivar; Roger G Ptak; Michelle G Davis; Karen K Biron; Leroy B Townsend; John C Drach
Phosphorylation of beta-D-ribosylbenzimidazoles is not required for activity against human cytomegalovirus.
Antimicrobial agents and chemotherapy 2002;46(2):478-86.
2001: Ruifang Wang; Mohamad Ksebati; Thomas H Corbett; Earl R Kern; John C Drach; Jiri Zemlicka
Methylene-gem-difluorocyclopropane analogues of nucleosides: synthesis, cyclopropene-methylenecyclopropane rearrangement, and biological activity.
Journal of medicinal chemistry 2001;44(23):4019-22.
2001: Ruifang Wang; Mohamad Ksebati; John C Drach; Jiri Zemlicka
Synthesis and antiviral activity of methylenedifluorocyclopropane analogues of nucleosides.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):329-32.
2000: Paula M Krosky; Roger G Ptak; Mark Richard Underwood; Karen K Biron; Leroy B Townsend; John C Drach
Differences in DNA packaging genes and sensitivity to benzimidazole ribonucleosides between human cytomegalovirus strains AD169 and Towne.
Antiviral chemistry & chemotherapy 2000;11(5):349-52.
2000: Kristjan S Gudmundsson; George A Freeman; John C Drach; Leroy B Townsend
Synthesis of fluorosugar analogues of 2,5,6-trichloro-1-(beta-D-ribofuranosyl)benzimidazole as antivirals with potentially increased glycosidic bond stability.
Journal of medicinal chemistry 2000;43(12):2473-8.
2000: Kristjan S Gudmundsson; Jeffrey H Tidwell; N Lippa; George W Koszalka; N van Draanen; Roger G Ptak; John C Drach; Leroy B Townsend
Synthesis and antiviral evaluation of halogenated beta-D- and -L-erythrofuranosylbenzimidazoles.
Journal of medicinal chemistry 2000;43(12):2464-72.
2000: Anthony R Porcari; Roger G Ptak; Katherine Z Borysko; Julie M Breitenbach; John C Drach; Leroy B Townsend
6-N-Acyltriciribine analogues: structure-activity relationship between acyl carbon chain length and activity against HIV-1.
Journal of medicinal chemistry 2000;43(12):2457-63.
2000: Jiong J Chen; Y Wei; John C Drach; Leroy B Townsend
Synthesis and antiviral evaluation of trisubstituted indole N-nucleosides as analogues of 2,5,6-trichloro-1-(beta-D-ribofuranosyl)benzimidazole (TCRB).
Journal of medicinal chemistry 2000;43(12):2449-56.
2000: Anthony R Porcari; Roger G Ptak; Katherine Z Borysko; Julie M Breitenbach; S Vittori; LL Wotring; John C Drach; Leroy B Townsend
Deoxy sugar analogues of triciribine: correlation of antiviral and antiproliferative activity with intracellular phosphorylation.
Journal of medicinal chemistry 2000;43(12):2438-48.
2000: Z Zhu; B Lippa; John C Drach; Leroy B Townsend
Design, synthesis, and biological evaluation of tricyclic nucleosides (dimensional probes) as analogues of certain antiviral polyhalogenated benzimidazole ribonucleosides.
Journal of medicinal chemistry 2000;43(12):2430-7.
2000: YL Qiu; F Geiser; T Kira; Elizabeth Gullen; Yung-Chi Cheng; Roger G Ptak; Julie M Breitenbach; John C Drach; Caroll B Hartline; Earl R Kern; Jiri Zemlicka
Synthesis and enantioselectivity of the antiviral effects of (R,Z)-,(S,Z)-methylenecyclopropane analogues of purine nucleosides and phosphoralaninate prodrugs: influence of heterocyclic base, type of virus and host cells.
Antiviral chemistry & chemotherapy 2000;11(3):191-202.
2000: H P Guan; Mohamad Ksebati; Yung-Chi Cheng; John C Drach; Earl R Kern; Jiri Zemlicka
Spiropentane mimics of nucleosides: analogues of 2'-deoxyadenosine and 2'-deoxyguanosine. Synthesis of all stereoisomers, isomeric assignment, and biological activity.
The Journal of organic chemistry 2000;65(5):1280-90.
2000: R Zou; E Kawashima; George A Freeman; George W Koszalka; John C Drach; Leroy B Townsend
Design, synthesis, and antiviral evaluation of 2-deoxy-D-ribosides of substituted benzimidazoles as potential agents for human cytomegalovirus infections.
Nucleosides, nucleotides & nucleic acids 2000;19(1-2):125-53.
2000: Joseph H Chan; Stanley D Chamberlain; Karen K Biron; Michelle G Davis; Robert J Harvey; Dean W Selleseth; Ronna E Dornsife; E H Dark; Lloyd Frick; Leroy B Townsend; John C Drach; George W Koszalka
Synthesis and evaluation of a series of 2'-deoxy analogues of the antiviral agent 5,6-dichloro-2-isopropylamino-1-(beta-L-ribofuranosyl)-1H-benzimidazole (1263W94).
Nucleosides, nucleotides & nucleic acids 2000;19(1-2):101-23.
2000: S Krawczyk; Michael T Migawa; John C Drach; Leroy B Townsend
Synthesis of 4-substituted imidazo[4,5-d][1,2,3]triazine (2-azapurine)nucleosides.
Nucleosides, nucleotides & nucleic acids 2000;19(1-2):39-68.
1999: Anthony R Porcari; Katherine Z Borysko; Roger G Ptak; Julie M Breitenbach; LL Wotring; John C Drach; Leroy B Townsend
Acyclic sugar analogs of triciribine: lack of antiviral and antiproliferative activity correlate with low intracellular phosphorylation.
Nucleosides & nucleotides 1999;18(11-12):2475-97.
1999: YL Qiu; Roger G Ptak; Julie M Breitenbach; JS Lin; Yung-Chi Cheng; John C Drach; Earl R Kern; Jiri Zemlicka
Synthesis and antiviral activity of phosphoralaninate derivatives of methylenecyclopropane analogues of nucleosides.
Antiviral research 1999;43(1):37-53.
1999: Jennie Jacobson; T E Renau; M Reza Nassiri; Domenica G Sweier; Julie M Breitenbach; Leroy B Townsend; John C Drach
Nonnucleoside pyrrolopyrimidines with a unique mechanism of action against human cytomegalovirus.
Antimicrobial agents and chemotherapy 1999;43(8):1888-94.
1999: YL Qiu; Andrew Hempel; Norman Camerman; Arthur Camerman; F Geiser; Roger G Ptak; Julie M Breitenbach; T Kira; L Li; Elizabeth Gullen; Yung-Chi Cheng; John C Drach; Jiri Zemlicka
Methylenecyclopropane analogues of nucleosides: synthesis, absolute configuration, and enantioselectivity of antiviral effect of (R)-(-)- and (S)-(+)-synadenol.
Nucleosides & nucleotides 1999;18(4-5):597-8.
1999: Leroy B Townsend; Kristjan S Gudmundsson; Susan M Daluge; Jiong J Chen; Z Zhu; George W Koszalka; L Boyd; Stanley D Chamberlain; George A Freeman; Karen K Biron; John C Drach
Studies designed to increase the stability and antiviral activity (HCMV) of the active benzimidazole nucleoside, TCRB.
Nucleosides & nucleotides 1999;18(4-5):509-19.
1998: YL Qiu; Andrew Hempel; Norman Camerman; Arthur Camerman; F Geiser; Roger G Ptak; Julie M Breitenbach; T Kira; L Li; Elizabeth Gullen; Yung-Chi Cheng; John C Drach; Jiri Zemlicka
(R)-(-)- and (S)-(+)-Synadenol: synthesis, absolute configuration, and enantioselectivity of antiviral effect.
Journal of medicinal chemistry 1998;41(26):5257-64.
1998: Roger G Ptak; Katherine Z Borysko; Anthony R Porcari; J L Buthod; L E Holland; C Shipman; Leroy B Townsend; John C Drach
Phosphorylation of triciribine is necessary for activity against HIV type 1.
AIDS research and human retroviruses 1998;14(15):1315-22.
1998: YL Qiu; Roger G Ptak; Julie M Breitenbach; JS Lin; Yung-Chi Cheng; Earl R Kern; John C Drach; Jiri Zemlicka
(Z)- and (E)-2-(hydroxymethylcyclopropylidene)-methylpurines and pyrimidines as antiviral agents.
Antiviral chemistry & chemotherapy 1998;9(4):341-52.
1998: Paula M Krosky; Mark Richard Underwood; S R Turk; K W Feng; R K Jain; Roger G Ptak; A C Westerman; Karen K Biron; Leroy B Townsend; John C Drach
Resistance of human cytomegalovirus to benzimidazole ribonucleosides maps to two open reading frames: UL89 and UL56.
Journal of virology 1998;72(6):4721-8.
1998: Michael T Migawa; J L Girardet; J A Walker; George W Koszalka; Stanley D Chamberlain; John C Drach; Leroy B Townsend
Design, synthesis, and antiviral activity of alpha-nucleosides: D- and L-isomers of lyxofuranosyl- and (5-deoxylyxofuranosyl)benzimidazoles.
Journal of medicinal chemistry 1998;41(8):1242-51.
1998: Anthony R Porcari; R V Devivar; L S Kucera; John C Drach; Leroy B Townsend
Design, synthesis, and antiviral evaluations of 1-(substituted benzyl)-2-substituted-5,6-dichlorobenzimidazoles as nonnucleoside analogues of 2,5,6-trichloro-1-(beta-D-ribofuranosyl)benzimidazole.
Journal of medicinal chemistry 1998;41(8):1252-62.
1998: J A Walker; W Liu; DS Wise; John C Drach; Leroy B Townsend
Synthesis and antiviral evaluation of certain novel pyrazinoic acid C-nucleosides.
Journal of medicinal chemistry 1998;41(8):1236-41.
1998: YL Qiu; Mohamad Ksebati; Roger G Ptak; B Y Fan; Julie M Breitenbach; JS Lin; Yung-Chi Cheng; Earl R Kern; John C Drach; Jiri Zemlicka
(Z)- and (E)-2-((hydroxymethyl)cyclopropylidene)methyladenine and -guanine. New nucleoside analogues with a broad-spectrum antiviral activity.
Journal of medicinal chemistry 1998;41(1):10-23.
1998: Mark Richard Underwood; Robert J Harvey; Sylvia C Stanat; M L Hemphill; T Miller; John C Drach; Leroy B Townsend; Karen K Biron
Inhibition of human cytomegalovirus DNA maturation by a benzimidazole ribonucleoside is mediated through the UL89 gene product.
Journal of virology 1998;72(1):717-25.
1997: Russell Taichman; M Reza Nassiri; MJ Reilly; Roger G Ptak; Stephen G Emerson; John C Drach
Infection and replication of human cytomegalovirus in bone marrow stromal cells: effects on the production of IL-6, MIP-1alpha, and TGF-beta1.
Bone marrow transplantation 1997;19(5):471-80.
1997: R Zou; John C Drach; Leroy B Townsend
Design, synthesis, and antiviral evaluation of 2-chloro-5,6-dihalo-1-beta-D-ribofuranosylbenzimidazoles as potential agents for human cytomegalovirus infections.
Journal of medicinal chemistry 1997;40(5):811-8.
1997: R Zou; John C Drach; Leroy B Townsend
Design, synthesis, and antiviral evaluation of 2-substituted 4,5-dichloro- and 4,6-dichloro-1-beta-D-ribofuranosylbenzimidazoles as potential agents for human cytomegalovirus infections.
Journal of medicinal chemistry 1997;40(5):802-10.
1997: E A Meade; LL Wotring; John C Drach; Leroy B Townsend
Synthesis and antiproliferative and antiviral activity of carbohydrate-modified pyrrolo[2,3-d]pyridazin-7-one nucleosides.
Journal of medicinal chemistry 1997;40(5):794-801.
1997: Kristjan S Gudmundsson; John C Drach; LL Wotring; Leroy B Townsend
Synthesis and antiviral activity of certain 5'-modified analogs of 2,5,6-trichloro-1-(beta-D-ribofuranosyl)benzimidazole.
Journal of medicinal chemistry 1997;40(5):785-93.
1997: E E Swayze; John C Drach; LL Wotring; Leroy B Townsend
Synthesis, antiproliferative and antiviral activity of imidazo[4,5-d]isothiazole nucleosides as 5:5 fused analogs of nebularine and 6-methylpurine ribonucleoside.
Journal of medicinal chemistry 1997;40(5):771-84.
1996: R Zou; K R Ayres; John C Drach; Leroy B Townsend
Synthesis and antiviral evaluation of certain disubstituted benzimidazole ribonucleosides.
Journal of medicinal chemistry 1996;39(18):3477-82.
1996: T E Renau; C Kennedy; Roger G Ptak; Julie M Breitenbach; John C Drach; Leroy B Townsend
Synthesis of non-nucleoside analogs of toyocamycin, sangivamycin, and thiosangivamycin: the effect of certain 4- and 4,6-substituents on the antiviral activity of pyrrolo[2,3-d]pyrimidines.
Journal of medicinal chemistry 1996;39(18):3470-6.
1996: M Reza Nassiri; Stephen G Emerson; R V Devivar; Leroy B Townsend; John C Drach; Russell Taichman
Comparison of benzimidazole nucleosides and ganciclovir on the in vitro proliferation and colony formation of human bone marrow progenitor cells.
British journal of haematology 1996;93(2):273-9.
1996: S Saluja; R Zou; John C Drach; Leroy B Townsend
Structure-activity relationships among 2-substituted 5,6-dichloro-, 4,6-dichloro-, and 4,5-dichloro-1-[(2-hydroxyethoxy) methyl]- and -1-[(1,3-dihydroxy-2-propoxy) methyl]benzimidazoles.
Journal of medicinal chemistry 1996;39(4):881-91.
1996: T E Renau; LL Wotring; John C Drach; Leroy B Townsend
Synthesis of non-nucleoside analogs of toyocamycin, sangivamycin, and ++thiosangivamycin: influence of various 7-substituents on antiviral activity.
Journal of medicinal chemistry 1996;39(4):873-80.
1995: S H Krawczyk; T E Renau; M Reza Nassiri; A C Westerman; LL Wotring; John C Drach; Leroy B Townsend
Synthesis and evaluation of certain thiosangivamycin analogs as potential inhibitors of cell proliferation and human cytomegalovirus.
Journal of medicinal chemistry 1995;38(20):4115-9.
1995: S H Krawczyk; M Reza Nassiri; L S Kucera; Earl R Kern; Roger G Ptak; LL Wotring; John C Drach; Leroy B Townsend
Synthesis and antiproliferative and antiviral activity of 2'-deoxy-2'-fluoroarabinofuranosyl analogs of the nucleoside antibiotics toyocamycin and sangivamycin.
Journal of medicinal chemistry 1995;38(20):4106-14.
1995: Leroy B Townsend; R V Devivar; S R Turk; M Reza Nassiri; John C Drach
Design, synthesis, and antiviral activity of certain 2,5,6-trihalo-1-(beta-D-ribofuranosyl)benzimidazoles.
Journal of medicinal chemistry 1995;38(20):4098-105.
1994: A F Lewis; John C Drach; S M Fennewald; J H Huffman; Roger G Ptak; Jean-Pierre Sommadossi; G R Revankar; RF Rando
Inhibition of human cytomegalovirus in culture by alkenyl guanine analogs of the thiazolo[4,5-d]pyrimidine ring system.
Antimicrobial agents and chemotherapy 1994;38(12):2889-95.
1994: R V Devivar; E Kawashima; G R Revankar; Julie M Breitenbach; E D Kreske; John C Drach; Leroy B Townsend
Benzimidazole ribonucleosides: design, synthesis, and antiviral activity of certain 2-(alkylthio)- and 2-(benzylthio)-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazoles.
Journal of medicinal chemistry 1994;37(18):2942-9.
1994: T E Renau; J S Lee; H Kim; C G Young; LL Wotring; Leroy B Townsend; John C Drach
Relationship between cytotoxicity and conversion of thiosangivamycin analogs to toyocamycin analogs in cell culture medium.
Biochemical pharmacology 1994;48(4):801-7.
1993: E A Meade; LL Wotring; John C Drach; Leroy B Townsend
Synthesis, antiproliferative, and antiviral activity of 4-amino-1-(beta-D-ribofuranosyl)pyrrolo[2,3-d]pyridazin-7(6H)-one and related derivatives.
Journal of medicinal chemistry 1993;36(24):3834-42.
1992: T E Renau; M Reza Nassiri; E E Swayze; Earl R Kern; Leroy B Townsend; John C Drach
Improved synthesis and biological evaluation of an acyclic thiosangivamycin active against human cytomegalovirus.
Antiviral research 1992;19(1):15-28.
1992: E A Meade; LL Wotring; John C Drach; Leroy B Townsend
Synthesis, antiproliferative, and antiviral activity of certain 4-aminopyrrolo[2,3-d]pyridazine nucleosides: an entry into a novel series of adenosine analogues.
Journal of medicinal chemistry 1992;35(3):526-33.
1991: M Reza Nassiri; S R Turk; G M Birch; L A Coleman; J L Hudson; J S Pudlo; Leroy B Townsend; John C Drach
Activity of acyclic halogenated tubercidin analogs against human cytomegalovirus and in uninfected cells.
Antiviral research 1991;16(2):135-50.
1991: Leroy B Townsend; John C Drach; LL Wotring; S Vittori; J S Pudlo; E E Swayze; Pavan K Gupta; T Maruyama; N Saxena; L A Coleman
Design, synthesis, and studies on the structure activity relationships of certain pyrrolo[2,3-d]pyrimidine nucleosides and structurally related analogs as potential antineoplastic and antiviral agents.
Farmaco (Società chimica italiana : 1989) 1991;46(1 Suppl):113-39.
1990: S H Krawczyk; M Bernier-Rodriguez; M Reza Nassiri; Earl R Kern; LL Wotring; John C Drach; Leroy B Townsend
Arabinofuranosylpyrrolo[2,3-d]pyrimidines as potential agents for human cytomegalovirus infections.
Journal of medicinal chemistry 1990;33(12):3160-9.
1990: J S Pudlo; M Reza Nassiri; Earl R Kern; LL Wotring; John C Drach; Leroy B Townsend
Synthesis, antiproliferative, and antiviral activity of certain 4-substituted and 4,5-disubstituted 7-[(1,3-dihydroxy-2-propoxy)methyl]pyrrolo[2,3-d]pyrimidines.
Journal of medicinal chemistry 1990;33(7):1984-92.
1990: N K Saxena; L A Coleman; John C Drach; Leroy B Townsend
Synthesis and antiviral activity of some 7-[(2-hydroxyethoxy)methyl]pyrazolo[3,4-d]pyrimidine analogues of sangivamycin and toyocamycin.
Journal of medicinal chemistry 1990;33(7):1980-3.
1990: Mark Prichard; S R Turk; L A Coleman; S L Engelhardt; C Shipman; John C Drach
A microtiter virus yield reduction assay for the evaluation of antiviral compounds against human cytomegalovirus and herpes simplex virus.
Journal of virological methods 1990;28(1):101-6.
1990: M Reza Nassiri; J L Hudson; J S Pudlo; G M Birch; Leroy B Townsend; John C Drach
Flow cytometric evaluation of the cytotoxicity of novel antiviral compounds.
Cytometry 1990;11(3):411-7.
1989: G M Birch; S H Krawczyk; Leroy B Townsend; John C Drach
Antagonism of the cytotoxic but not antiviral effects of ara-sangivamycin by adenosine.
Antimicrobial agents and chemotherapy 1989;33(9):1606-8.
1989: Pavan K Gupta; M Reza Nassiri; L A Coleman; LL Wotring; John C Drach; Leroy B Townsend
Synthesis, cytotoxicity, and antiviral activity of certain 7-[(2-hydroxyethoxy)methyl]pyrrolo[2,3-d]pyrimidine nucleosides related to toyocamycin and sangivamycin.
Journal of medicinal chemistry 1989;32(7):1420-5.
1989: Pavan K Gupta; Sylvia Daunert; M Reza Nassiri; LL Wotring; John C Drach; Leroy B Townsend
Synthesis, cytotoxicity, and antiviral activity of some acyclic analogues of the pyrrolo[2,3-d]pyrimidine nucleoside antibiotics tubercidin, toyocamycin, and sangivamycin.
Journal of medicinal chemistry 1989;32(2):402-8.
1988: J S Pudlo; N K Saxena; M Reza Nassiri; S R Turk; John C Drach; Leroy B Townsend
Synthesis and antiviral activity of certain 4- and 4,5-disubstituted 7-[(2-hydroxyethoxy)methyl]pyrrolo[2,3-d]pyrimidines.
Journal of medicinal chemistry 1988;31(11):2086-92.
1988: N K Saxena; B M Hagenow; G Genzlinger; S R Turk; John C Drach; Leroy B Townsend
Synthesis and antiviral activity of certain 4-substituted and 2,4-disubstituted 7-[(2-hydroxyethoxy)methyl]pyrrolo[2,3-d]pyrimidines.
Journal of medicinal chemistry 1988;31(8):1501-6.
1988: M Nasr; John C Drach; S H Smith; C Shipman; J H Burckhalter
7-Aminoquinolines. A novel class of agents active against herpesviruses.
Journal of medicinal chemistry 1988;31(7):1347-51.
1987: S R Turk; Phillip Cook; C M Reinke; John C Drach
Inhibition of herpes simplex virus DNA replication by ara-tubercidin.
Antiviral research 1987;8(2):97-102.
1987: S R Turk; C Shipman; R Nassiri; G Genzlinger; S H Krawczyk; Leroy B Townsend; John C Drach
Pyrrolo[2,3-d]pyrimidine nucleosides as inhibitors of human cytomegalovirus.
Antimicrobial agents and chemotherapy 1987;31(4):544-50.
1986: S R Turk; C Shipman; John C Drach
Structure-activity relationships among alpha-(N)-heterocyclic acyl thiosemicarbazones and related compounds as inhibitors of herpes simplex virus type 1-specified ribonucleoside diphosphate reductase.
The Journal of general virology 1986;67 ( Pt 8)():1625-32.
1986: C Shipman; S H Smith; John C Drach; D L Klayman
Thiosemicarbazones of 2-acetylpyridine, 2-acetylquinoline, 1-acetylisoquinoline, and related compounds as inhibitors of herpes simplex virus in vitro and in a cutaneous herpes guinea pig model.
Antiviral research 1986;6(4):197-222.
1986: S R Turk; C Shipman; John C Drach
Selective inhibition of herpes simplex virus ribonucleoside diphosphate reductase by derivatives of 2-acetylpyridine thiosemicarbazone.
Biochemical pharmacology 1986;35(9):1539-45.
1984: P M Schwartz; J Novack; C Shipman; John C Drach
Metabolism of arabinosyladenine in herpes simplex virus-infected and uninfected cells. Correlation with inhibition of DNA synthesis and role in antiviral selectivity.
Biochemical pharmacology 1984;33(15):2431-8.
1984: N H Rowe; C Shipman; John C Drach
Herpes simplex virus disease: implications for dental personnel. Council on Dental Therapeutics.
Journal of the American Dental Association (1939) 1984;108(3):381-2.
1984: J W Barnett; C M Reinke; S R Turk; John C Drach
DNA polymerase in nuclei isolated from herpes simplex virus type-2-infected cells. Characterization of the reaction product and inhibition by substrate analogs.
Biochimica et biophysica acta 1984;781(1-2):130-42.
1983: C Shipman; S L Tong; S H Smith; N B Katlama; John C Drach
Establishment of a murine cell line resistant to arabinosyladenine and devoid of adenosine deaminase activity.
Antimicrobial agents and chemotherapy 1983;24(6):947-9.
1983: D C Baker; R P Crews; T H Haskell; S R Putt; G Arnett; W M Shannon; C M Reinke; N B Katlama; John C Drach
An evaluation of certain chain-extended analogues of 9-beta-D-arabinofuranosyladenine for antiviral and cardiovascular activity.
Journal of medicinal chemistry 1983;26(10):1530-4.
1981: LL Bennett; Paula W Allan; Sue C Shaddix; W M Shannon; G Arnett; L Westbrook; John C Drach; C M Reinke
Biological activities and modes of action of 9-alpha-D-arabinofuranosyladenine and 9-alpha-D-arabinofuranosyl-8-azaadenine.
Biochemical pharmacology 1981;30(16):2325-32.
1981: John C Drach; M A Thomas; J W Barnett; S H Smith; C Shipman
Tritiated thymidine incorporation does not measure DNA synthesis in ribavirin-treated human cells.
Science (New York, N.Y.) 1981;212(4494):549-51.
1981: C Shipman; S H Smith; John C Drach; D L Klayman
Antiviral activity of 2-acetylpyridine thiosemicarbazones against herpes simplex virus.
Antimicrobial agents and chemotherapy 1981;19(4):682-5.
1981: J C Pelling; John C Drach; C Shipman
Internucleotide incorporation of arabinosyladenine into herpes simplex virus and mammalian cell DNA.
Virology 1981;109(2):323-35.
1981: S L Brooks; N H Rowe; John C Drach; C Shipman; S K Young
Prevalence of herpes simplex virus disease in a professional population.
Journal of the American Dental Association (1939) 1981;102(1):31-4.
1980: K Ishidate; John C Drach; J E Sinsheimer; J H Burckhalter
Inhibition of hepatic lipid biosynthesis by 1-(3-chlorophenyl)-1-methyl-2-phenyl-2-(2-pyridine) ethanol, a hypocholesterolemic agent.
Biochemical pharmacology 1980;29(23):3207-10.