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Giulio Draetta

Research Profile

Chemicals & Drugs

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Publications

TOP 3
Giulio F Draetta; Ronald A DePinho
Cancer drug discovery faces the FACT.
Clay L Efferson; Christopher T Winkelmann; Christopher Ware; Timothy Sullivan; Saverio Giampaoli; Jennifer Tammam; Shailendra Patel; Giuseppe Mesiti; John F Reilly; Raymond E Gibson; Carolyn Buser; Timothy Yeatman; Domenico Coppola; Christopher Winter; Edwin A Clark; Giulio F Draetta; Peter R Strack; Pradip K Majumder
Downregulation of Notch pathway by a gamma-secretase inhibitor attenuates AKT/mammalian target of rapamycin signaling and glucose uptake in an ERBB2 transgenic breast cancer model.
Sudhir S Rao; Jennifer O'Neil; Cole D Liberator; James S Hardwick; Xudong Dai; Theresa Zhang; Edyta Tyminski; Jing Yuan; Nancy E Kohl; Victoria M Richon; Lex H T Van Der Ploeg; Pamela M Carroll; Giulio F Draetta; A Thomas Look; Peter R Strack; Christopher G Winter
Inhibition of NOTCH signaling by gamma secretase inhibitor engages the RB pathway and elicits cell cycle exit in T-cell acute lymphoblastic leukemia cells.

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All Publications

2011: Giulio F Draetta; Ronald A DePinho
Cancer drug discovery faces the FACT.
Science translational medicine 2011;3(95):95ps34.
2010: Clay L Efferson; Christopher T Winkelmann; Christopher Ware; Timothy Sullivan; Saverio Giampaoli; Jennifer Tammam; Shailendra Patel; Giuseppe Mesiti; John F Reilly; Raymond E Gibson; Carolyn Buser; Timothy Yeatman; Domenico Coppola; Christopher Winter; Edwin A Clark; Giulio F Draetta; Peter R Strack; Pradip K Majumder
Downregulation of Notch pathway by a gamma-secretase inhibitor attenuates AKT/mammalian target of rapamycin signaling and glucose uptake in an ERBB2 transgenic breast cancer model.
Cancer research 2010;70(6):2476-84.
2009: Sudhir S Rao; Jennifer O'Neil; Cole D Liberator; James S Hardwick; Xudong Dai; Theresa Zhang; Edyta Tyminski; Jing Yuan; Nancy E Kohl; Victoria M Richon; Lex H T Van Der Ploeg; Pamela M Carroll; Giulio F Draetta; A Thomas Look; Peter R Strack; Christopher G Winter
Inhibition of NOTCH signaling by gamma secretase inhibitor engages the RB pathway and elicits cell cycle exit in T-cell acute lymphoblastic leukemia cells.
Cancer research 2009;69(7):3060-8.
2007: Jennifer O'Neil; Jonathan Grim; Peter Strack; Sudhir Rao; Deanne Tibbitts; Christopher Winter; James Hardwick; Markus Welcker; Jules P P Meijerink; Rob Pieters; Giulio F Draetta; Rosalie C Pelz; Bruce E Clurman; A Thomas Look
FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors.
The Journal of experimental medicine 2007;204(8):1813-24.
2007: Silvia Senese; Katrin Zaragoza; Simone Minardi; Ivan Muradore; Simona Ronzoni; Alfonso Passafaro; Loris Bernard; Giulio F Draetta; Myriam Alcalay; Christian Seiser; Susanna Chiocca
Role for histone deacetylase 1 in human tumor cell proliferation.
Molecular and cellular biology 2007;27(13):4784-95.
2007: Luca Busino; Florian Bassermann; Alessio Maiolica; Choogon Lee; Patrick M Nolan; Sofia I H Godinho; Giulio F Draetta; Michele Pagano
SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins.
Science (New York, N.Y.) 2007;316(5826):900-4.
2007: Huw D Lewis; Matthew Leveridge; Peter R Strack; Christine D Haldon; Jennifer O'Neil; Hellen Kim; Andrew Madin; Joanne C Hannam; A Thomas Look; Nancy Kohl; Giulio F Draetta; Timothy Harrison; Julie A Kerby; Mark S Shearman; Dirk Beher
Apoptosis in T cell acute lymphoblastic leukemia cells after cell cycle arrest induced by pharmacological inhibition of notch signaling.
Chemistry & biology 2007;14(2):209-19.
2006: Maria Capra; Paolo Giovanni Nuciforo; Stefano Confalonieri; Micaela Quarto; Marco Bianchi; Manuela Nebuloni; Renzo Boldorini; Francesco Pallotti; Giuseppe Viale; Mikhail L Gishizky; Giulio F Draetta; Pier Paolo Di Fiore
Frequent alterations in the expression of serine/threonine kinases in human cancers.
Cancer research 2006;66(16):8147-54.
2006: Massimo Squatrito; Monica Mancino; Leonardo Sala; Giulio F Draetta
Ebp1 is a dsRNA-binding protein associated with ribosomes that modulates eIF2alpha phosphorylation.
Biochemical and biophysical research communications 2006;344(3):859-68.
2005: Giulio F Draetta
Commentary on "A new cancer diagnostic system based on a CDK profiling technology" [Biochim. Biophys. Acta Molecular Basis of Disease 1741 (2005) 226-233].
Biochimica et biophysica acta 2005;1741(3):225.
2005: Dipankar Ray; Yasuhisa Terao; Dipali Nimbalkar; Li-Hao Chu; Maddalena Donzelli; Tateki Tsutsui; Xianghong Zou; Asish K Ghosh; john varga; Giulio F Draetta; Hiroaki Kiyokawa
Transforming growth factor beta facilitates beta-TrCP-mediated degradation of Cdc25A in a Smad3-dependent manner.
Molecular and cellular biology 2005;25(8):3338-47.
2004: Roberto Boggio; Riccardo Colombo; Ron Thomas Hay; Giulio F Draetta; Susanna Chiocca
A mechanism for inhibiting the SUMO pathway.
Molecular cell 2004;16(4):549-61.
2004: Barbara Masciadri; Liliana B Areces; Patrizia Carpinelli; Marco Foiani; Giulio F Draetta; Francesca Fiore
Characterization of the BUD31 gene of Saccharomyces cerevisiae.
Biochemical and biophysical research communications 2004;320(4):1342-50.
2004: Massimo Squatrito; Monica Mancino; Maddalena Donzelli; Liliana B Areces; Giulio F Draetta
EBP1 is a nucleolar growth-regulating protein that is part of pre-ribosomal ribonucleoprotein complexes.
Oncogene 2004;23(25):4454-65.
2004: Maddalena Donzelli; Luca Busino; Massimo Chiesa; Dvora Ganoth; Avram Hershko; Giulio F Draetta
Hierarchical order of phosphorylation events commits Cdc25A to betaTrCP-dependent degradation.
Cell cycle (Georgetown, Tex.) 2004;3(4):469-71.
2004: Luca Busino; Massimo Chiesa; Giulio F Draetta; Maddalena Donzelli
Cdc25A phosphatase: combinatorial phosphorylation, ubiquitylation and proteolysis.
Oncogene 2004;23(11):2050-6.
2003: Luca Busino; Maddalena Donzelli; Massimo Chiesa; Daniele Guardavaccaro; Dvora Ganoth; N Valerio Dorrello; Avram Hershko; Michele Pagano; Giulio F Draetta
Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage.
Nature 2003;426(6962):87-91.
2003: Maddalena Donzelli; Giulio F Draetta
Regulating mammalian checkpoints through Cdc25 inactivation.
EMBO reports 2003;4(7):671-7.
2003: Riccardo Colombo; Giulio F Draetta; Susanna Chiocca
Modulation of p120E4F transcriptional activity by the Gam1 adenoviral early protein.
Oncogene 2003;22(17):2541-7.
2002: Riccardo Colombo; Roberto Boggio; Christian Seiser; Giulio F Draetta; Susanna Chiocca
The adenovirus protein Gam1 interferes with sumoylation of histone deacetylase 1.
EMBO reports 2002;3(11):1062-8.
2002: Maddalena Donzelli; Massimo Squatrito; Dvora Ganoth; Avram Hershko; Michele Pagano; Giulio F Draetta
Dual mode of degradation of Cdc25 A phosphatase.
The EMBO journal 2002;21(18):4875-84.
2002: Susanna Chiocca; Vladislav Kurtev; Riccardo Colombo; Roberto Boggio; Maria Teresa Sciurpi; Gerald Brosch; Christian Seiser; Giulio F Draetta; Matt Cotten
Histone deacetylase 1 inactivation by an adenovirus early gene product.
Current biology : CB 2002;12(7):594-8.
2001: Geneviève Rodier; A Montagnoli; L Di Marcotullio; Philippe Coulombe; Giulio F Draetta; Michele Pagano; Sylvain Meloche
p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis.
The EMBO journal 2001;20(23):6672-82.
2001: C Soncini; I Berdo; Giulio F Draetta
Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease.
Oncogene 2001;20(29):3869-79.
2000: M Molinari; C Mercurio; J Dominguez; F Goubin; Giulio F Draetta
Human Cdc25 A inactivation in response to S phase inhibition and its role in preventing premature mitosis.
EMBO reports 2000;1(1):71-9.
1999: Roberto Piva; I Cancelli; Paola Cavalla; Simona Bortolotto; J Dominguez; Giulio F Draetta; Davide Schiffer
Proteasome-dependent degradation of p27/kip1 in gliomas.
Journal of neuropathology and experimental neurology 1999;58(7):691-6.
1999: A Montagnoli; F Fiore; Esther Eytan; Andrea C. Carrano; Giulio F Draetta; Avram Hershko; Michele Pagano
Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation.
Genes & development 1999;13(9):1181-9.
1998: S Naviglio; C Mattecucci; B Matoskova; T Nagase; N Nomura; Pier Paolo Di Fiore; Giulio F Draetta
UBPY: a growth-regulated human ubiquitin isopeptidase.
The EMBO journal 1998;17(12):3241-50.
1998: Giulio F Draetta
11th European Cell Cycle Conference: April 23-26, 1997, Gardone Riviera (Italy) and Symposium on Cell Cycle Regulation (17th International Congress of Biochemistry and Molecular Biology): August 24-29, 1997, San Francisco, CA.
Biochimica et biophysica acta 1998;1377(1):R11-20.
1997: L Lamphere; F Fiore; X Xu; leonardo brizuela; S Keezer; C Sardet; Giulio F Draetta; J Gyuris
Interaction between Cdc37 and Cdk4 in human cells.
Oncogene 1997;14(16):1999-2004.
1997: Giulio F Draetta; J Eckstein
Cdc25 protein phosphatases in cell proliferation.
Biochimica et biophysica acta 1997;1332(2):M53-63.
1997: Giulio F Draetta
Cell cycle: will the real Cdk-activating kinase please stand up.
Current biology : CB 1997;7(1):R50-2.