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Fotios Drenos

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Philippa J Talmud; John Whittaker; Ros A Whittall; Jackie A Cooper; Olivier S Descamps; Fotios Drenos; Marta Futema; Seamus C Harrison; Aroon D Hingorani; Philip Howard; Frederik Karpe; Mika Kivimaki; Meena Kumari; Claudia Langenberg; Nicholas Lench; Kawah Li; H Andrew W Neil; Sonia Shah; Steve E Humphries
Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: a case-control study.
Folkert W Asselbergs; Ruth C Lovering; Fotios Drenos
Progress in genetic association studies of plasma lipids.
Sonia Shah; Tina Shah; George Davey Smith; Reecha Sofat; Daniel I Swerdlow; Philippa J Talmud; John Whittaker; Delilah Zabaneh; Juan P Casas; Jackie Cooper; Ian N M Day; Fotios Drenos; Shah Ebrahim; Tom R Gaunt; Aroon D Hingorani; Mika Kivimaki; Meena Kumari; Debbie A Lawlor; Jutta Palmen; Steve E Humphries
Influence of common genetic variation on blood lipid levels, cardiovascular risk, and coronary events in two British prospective cohort studies.

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All Publications

2013: Philippa J Talmud; John Whittaker; Ros A Whittall; Jackie A Cooper; Olivier S Descamps; Fotios Drenos; Marta Futema; Seamus C Harrison; Aroon D Hingorani; Philip Howard; Frederik Karpe; Mika Kivimaki; Meena Kumari; Claudia Langenberg; Nicholas Lench; Kawah Li; H Andrew W Neil; Sonia Shah; Steve E Humphries
Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: a case-control study.
Lancet 2013;381(9874):1293-301.
2013: Folkert W Asselbergs; Ruth C Lovering; Fotios Drenos
Progress in genetic association studies of plasma lipids.
Current opinion in lipidology 2013;24(2):123-8.
2013: Sonia Shah; Tina Shah; George Davey Smith; Reecha Sofat; Daniel I Swerdlow; Philippa J Talmud; John Whittaker; Delilah Zabaneh; Juan P Casas; Jackie Cooper; Ian N M Day; Fotios Drenos; Shah Ebrahim; Tom R Gaunt; Aroon D Hingorani; Mika Kivimaki; Meena Kumari; Debbie A Lawlor; Jutta Palmen; Steve E Humphries
Influence of common genetic variation on blood lipid levels, cardiovascular risk, and coronary events in two British prospective cohort studies.
European heart journal 2013;34(13):972-81.
2013: Sonia Shah; Rona J Strawbridge; Daniel I Swerdlow; Philippa J Talmud; Elena Tremoli; Fabrizio Veglia; Nick Wareham; John Whittaker; Damiano Baldassarre; Juan P Casas; Ulf de Faire; John Deanfield; Fotios Drenos; Karl Gertow; Bruna Gigante; Anders Hamsten; Michael V Holmes; Steve E Humphries; Mika Kivimaki; Meena Kumari; Claudia Langenberg; Bengt Sennblad; Aroon D Hingorani
Causal relevance of blood lipid fractions in the development of carotid atherosclerosis: Mendelian randomization analysis.
Circulation. Cardiovascular genetics 2013;6(1):63-72.
2013: Kyriacos I Eleftheriou; Fares S Haddad; Steve E Humphries; Lindsay E James; Mike Loosemore; John R Payne; Dudley J Pennell; Jaikirty S Rawal; Julie Sanders; Michael J World; Fotios Drenos; Hugh E Montgomery
Bone structure and geometry in young men: the influence of smoking, alcohol intake and physical activity.
Bone 2013;52(1):17-26.
2012: Tom R Gaunt; Jules C Hancox; Aroon D Hingorani; Steve E Humphries; Mika Kivimaki; Meena Kumari; Debbie A Lawlor; Peter W Macfarlane; Christopher P Nelson; Nilesh J Samani; Sonia Shah; Philippa J Talmud; Martin D Tobin; Maciej Tomaszewski; John Whittaker; Henggui Zhang; Ismail Adeniran; Antoinette Amuzu; Peter Braund; Paul R Burton; Juan P Casas; Fotios Drenos; Per Eriksson; Lasse Folkersen; Ian N M Day
Integration of genetics into a systems model of electrocardiographic traits using HumanCVD BeadChip.
Circulation. Cardiovascular genetics 2012;5(6):630-8.
2012: Nikos Yiannakouris; J A Cooper; Fotios Drenos; R Elkeles; I F Godsland; A D Hingorani; H A Ireland; M Kivimaki; M Kumari; K-W Li; S Shah; J W Stephens; P J Talmud; S E Humphries
IRS1 gene variants, dysglycaemic metabolic changes and type-2 diabetes risk.
Nutrition, metabolism, and cardiovascular diseases : NMCD 2012;22(12):1024-30.
2012: Seán J Costelloe; Fotios Drenos; Julia S El-Sayed Moustafa; Anna-Liisa Hartikainen; Aroon D Hingorani; Steve E Humphries; Mika Kivimaki; Meena Kumari; Järvelin Marjo-Riitta; Jutta Palmen; Anneli Pouta; Li Qiao; Michael Thomas; Ioanna Tzoulaki; Robin G Walters; Stephen Whiting; Marjo-Riitta Järvelin; Qiao Li; Aimo Ruokonen; Ruokonen Aimo; Alexandra I F Blakemore; Lachlan J M Coin; Philippa J Talmud
Gene-targeted analysis of copy number variants identifies 3 novel associations with coronary heart disease traits.
Circulation. Cardiovascular genetics 2012;5(5):555-60.
2012: Gie Ken-Dror; Mika Kivimaki; Meena Kumari; Steve E Humphries; Fotios Drenos
A genetic instrument for Mendelian randomization of fibrinogen.
European journal of epidemiology 2012;27(4):267-79.
2012: Kyriacos I Eleftheriou; Fares S Haddad; Steve E Humphries; Laurence E James; Anthony Kehoe; Mike Loosemore; John R Payne; Dudley J Pennell; Zudin A Puthucheary; Jaikirty S Rawal; James R Skipworth; Michael World; Fotios Drenos; Hugh E Montgomery
The Lichfield bone study: the skeletal response to exercise in healthy young men.
Journal of applied physiology (Bethesda, Md. : 1985) 2012;112(4):615-26.
2011: Gie Ken-Dror; Jackie A Cooper; Fotios Drenos; Steve E Humphries; Helen A Ireland
Free protein S level as a risk factor for coronary heart disease and stroke in a prospective cohort study of healthy United Kingdom men.
American journal of epidemiology 2011;174(8):958-68.
2011: Delilah Zabaneh; Juan P Casas; Robert Clarke; Fotios Drenos; Gerry Fowkes; Aroon D Hingorani; Jemma Hopewell; Mika Kivimaki; Florian Kronenberg; Meena Kumari; Claudia Lamina; KaWah Li; Jutta Palmen; Theodore Papamarkou; Bernhard Paulweber; Jackie Price; Manj Sandhu; Shah Sonia; Tina Shah; Marlene Stewart; Monika Summerer; Philippa J Talmud; Nick Wainwright; Nick Wareham; John Whittaker; Steve E Humphries
Meta analysis of candidate gene variants outside the LPA locus with Lp(a) plasma levels in 14,500 participants of six White European cohorts.
Atherosclerosis 2011;217(2):447-51.
2011: Philippa J Talmud; J Whittaker; M Kivimaki; Meena Kumari; Debbie A Lawlor; Jutta Palmen; Shah Sonia; Tina Shah; J P Casas; Jackie A Cooper; Ian N M Day; Fotios Drenos; T Gaunt; Aroon D Hingorani; Michael Holmes; Steve E Humphries
Variants of ADRA2A are associated with fasting glucose, blood pressure, body mass index and type 2 diabetes risk: meta-analysis of four prospective studies.
Diabetologia 2011;54(7):1710-9.
2010: Gie Ken-Dror; Fotios Drenos; Steve E Humphries; Philippa J Talmud; Aroon D Hingorani; M Kivimäki; Meena Kumari; Kenneth A Bauer; James Morrissey; H A Ireland
Haplotype and genotype effects of the F7 gene on circulating factor VII, coagulation activation markers and incident coronary heart disease in UK men.
Journal of thrombosis and haemostasis : JTH 2010;8(11):2394-403.
2010: Andrew J P Smith; Jutta Palmen; Wendy Putt; Philippa J Talmud; Steve E Humphries; Fotios Drenos
Application of statistical and functional methodologies for the investigation of genetic determinants of coronary heart disease biomarkers: lipoprotein lipase genotype and plasma triglycerides as an exemplar.
Human molecular genetics 2010;19(20):3936-47.
2010: Gie Ken-Dror; Philippa J Talmud; Steve E Humphries; Fotios Drenos
APOE/C1/C4/C2 gene cluster genotypes, haplotypes and lipid levels in prospective coronary heart disease risk among UK healthy men.
Molecular medicine (Cambridge, Mass.) 2010;16(9-10):389-99.
2010: Steve E Humphries; Fotios Drenos; Gie Ken-Dror; Philippa J Talmud
Coronary heart disease risk prediction in the era of genome-wide association studies: current status and what the future holds.
Circulation 2010;121(20):2235-48.
2010: Andrew R Thompson; Jackie A Cooper; Gregory T Jones; Fotios Drenos; Frank M Van Bockxmeer; Erik Biros; Philip J Walker; Andre M van Rij; Jonathan Golledge; Paul E Norman; Hany Hafez; Stephen E Humphries
Assessment of the association between genetic polymorphisms in transforming growth factor beta, and its binding protein (LTBP), and the presence, and expansion, of Abdominal Aortic Aneurysm.
Atherosclerosis 2010;209(2):367-73.
2010: Fotios Drenos; Thomas B L Kirkwood
Selection on alleles affecting human longevity and late-life disease: the example of apolipoprotein E.
PloS one 2010;5(4):e10022.
2009: Philippa J Talmud; Fotios Drenos; Shah Sonia; Tina Shah; Jutta Palmen; Claudio Verzilli; Tom R Gaunt; Jacky Pallas; Ruth Lovering; Kawah Li; Juan P Casas; Reecha Sofat; Meena Kumari; Santiago Rodriguez; Toby Johnson; Stephen J Newhouse; Anna Dominiczak; Nilesh J Samani; Mark Caulfield; Peter Sever; Alice Stanton; Denis C Shields; Sandosh Padmanabhan; Olle Melander; Claire Hastie; Christian Delles; Shah Ebrahim; Michael Marmot; George Davey Smith; Debbie A Lawlor; Patricia B Munroe; Ian N Day; Mika Kivimaki; John Whittaker; Steve E Humphries; Aroon D Hingorani
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
American journal of human genetics 2009;85(5):628-42.
2009: Helen A Ireland; Jackie A Cooper; Fotios Drenos; Jayshree Acharya; Jacqueline P Mitchell; Ken A Bauer; James Morrissey; M Peter Esnouf; Stephen E Humphries
FVII, FVIIa, and downstream markers of extrinsic pathway activation differ by EPCR Ser219Gly variant in healthy men.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(11):1968-74.
2009: Fotios Drenos; Philippa J Talmud; Juan P Casas; Liam Smeeth; Jutta Palmen; Steve E Humphries; Aroon D Hingorani
Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk.
Human molecular genetics 2009;18(12):2305-16.
2008: Philippa J Talmud; Melissa Smart; Edward Presswood; Jackie A Cooper; Viviane Nicaud; Fotios Drenos; Jutta Palmen; Michael G Marmot; S Matthijs Boekholdt; Nicholas J Wareham; Kay-Tee Khaw; Meena Kumari; Steve E Humphries
ANGPTL4 E40K and T266M: effects on plasma triglyceride and HDL levels, postprandial responses, and CHD risk.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(12):2319-25.
2008: Philippa J Talmud; Jackie A Cooper; Jutta Palmen; Ruth Lovering; Fotios Drenos; Aroon D Hingorani; Steve E Humphries
Chromosome 9p21.3 coronary heart disease locus genotype and prospective risk of CHD in healthy middle-aged men.
Clinical chemistry 2008;54(3):467-74.
2008: Amal Muthumala; Fotios Drenos; Perry M Elliott; Steve E Humphries
Role of beta adrenergic receptor polymorphisms in heart failure: systematic review and meta-analysis.
European journal of heart failure 2008;10(1):3-13.
2007: Fotios Drenos; J C Whittaker; Steve E Humphries
The use of meta-analysis risk estimates for candidate genes in combination to predict coronary heart disease risk.
Annals of human genetics 2007;71(Pt 5):611-9.
2007: Peter T E Wootton; Nupur L Arora; Fotios Drenos; Simon R Thompson; Jackie A Cooper; Jeffrey W Stephens; Steven J Hurel; Eva Hurt-Camejo; Olov Wiklund; Steve E Humphries; Philippa J Talmud
Tagging SNP haplotype analysis of the secretory PLA2-V gene, PLA2G5, shows strong association with LDL and oxLDL levels, suggesting functional distinction from sPLA2-IIA: results from the UDACS study.
Human molecular genetics 2007;16(12):1437-44.
2007: Julian Thompson; James Raitt; Lynn Hutchings; Fotios Drenos; Eirik Bjargo; Are Loset; M P W Grocott; Hugh Montgomery
Angiotensin-converting enzyme genotype and successful ascent to extreme high altitude.
High altitude medicine & biology 2007;8(4):278-85.
2007: Fotios Drenos; George J Miller; Steve E Humphries
Increase of plasma fibrinogen levels and variability with age in a sample of middle aged healthy men.
Annals of human genetics 2007;71(Pt 1):43-53.
2006: Fotios Drenos; Rudi G J Westendorp; Thomas B L Kirkwood
Trade-off mediated effects on the genetics of human survival caused by increasingly benign living conditions.
Biogerontology 2006;7(4):287-95.
2006: Peter T E Wootton; Fotios Drenos; Jackie A Cooper; Simon R Thompson; Jeffrey W Stephens; Eva Hurt-Camejo; Olov Wiklund; Steve E Humphries; Philippa J Talmud
Tagging-SNP haplotype analysis of the secretory PLA2IIa gene PLA2G2A shows strong association with serum levels of sPLA2IIa: results from the UDACS study.
Human molecular genetics 2006;15(2):355-61.
2005: Fotios Drenos; Thomas B L Kirkwood
Modelling the disposable soma theory of ageing.
Mechanisms of ageing and development 2005;126(1):99-103.