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Huazhang An

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Pengyuan Yang; Huazhang An; Xingguang Liu; Mingyue Wen; Yuanyuan Zheng; Yaocheng Rui; Xuetao Cao
The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway.
Huazhang An; Cheng Qian; Xuetao Cao
Regulation of Toll-like receptor signaling in the innate immunity.
Chunmei Wang; Runzi Qi; Nan Li; Zhengxin Wang; Huazhang An; Qinghua Zhang; Yizhi Yu; Xuetao Cao
Notch1 signaling sensitizes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human hepatocellular carcinoma cells by inhibiting Akt/Hdm2-mediated p53 degradation and up-regulating p53-dependent DR5 expression.

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All Publications

2010: Pengyuan Yang; Huazhang An; Xingguang Liu; Mingyue Wen; Yuanyuan Zheng; Yaocheng Rui; Xuetao Cao
The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway.
Nature immunology 2010;11(6):487-94.
2010: Huazhang An; Cheng Qian; Xuetao Cao
Regulation of Toll-like receptor signaling in the innate immunity.
Science China. Life sciences 2010;53(1):34-43.
2009: Chunmei Wang; Runzi Qi; Nan Li; Zhengxin Wang; Huazhang An; Qinghua Zhang; Yizhi Yu; Xuetao Cao
Notch1 signaling sensitizes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human hepatocellular carcinoma cells by inhibiting Akt/Hdm2-mediated p53 degradation and up-regulating p53-dependent DR5 expression.
The Journal of biological chemistry 2009;284(24):16183-90.
2008: Hongmei Xu; Huazhang An; Jin Hou; Chaofeng Han; Pin Wang; Yizhi Yu; Xuetao Cao
Phosphatase PTP1B negatively regulates MyD88- and TRIF-dependent proinflammatory cytokine and type I interferon production in TLR-triggered macrophages.
Molecular immunology 2008;45(13):3545-52.
2008: Qiuyan Liu; Xiaoli Shu; Anna Sun; Qiaoling Sun; Chaoxiong Zhang; Huazhang An; Jikai Liu; Xuetao Cao
Plant-derived small molecule albaconol suppresses LPS-triggered proinflammatory cytokine production and antigen presentation of dendritic cells by impairing NF-kappaB activation.
International immunopharmacology 2008;8(8):1103-11.
2008: Huazhang An; Jin Hou; Jun Zhou; Wei Zhao; Hongmei Xu; Yuejuan Zheng; Yizhi Yu; Shuxun Liu; Xuetao Cao
Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1.
Nature immunology 2008;9(5):542-50.
2007: Cheng Qian; Huazhang An; Yizhi Yu; Shuxun Liu; Xuetao Cao
TLR agonists induce regulatory dendritic cells to recruit Th1 cells via preferential IP-10 secretion and inhibit Th1 proliferation.
Blood 2007;109(8):3308-15.
2007: Wei Zhao; Huazhang An; Jun Zhou; Hongmei Xu; Yizhi Yu; Xuetao Cao
Hyperthermia differentially regulates TLR4 and TLR2-mediated innate immune response.
Immunology letters 2007;108(2):137-42.
2006: Huazhang An; Wei Zhao; Jin Hou; Yan Zhang; Yun Xie; Yuejuan Zheng; Hongmei Xu; Cheng Qian; Jun Zhou; Yizhi Yu; Shuxun Liu; Gensheng Feng; Xuetao Cao
SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine production.
Immunity 2006;25(6):919-28.
2006: Cheng Qian; Xiaodong Jiang; Huazhang An; Yizhi Yu; Zhenhong Guo; Shuxun Liu; Hongmei Xu; Xuetao Cao
TLR agonists promote ERK-mediated preferential IL-10 production of regulatory dendritic cells (diffDCs), leading to NK-cell activation.
Blood 2006;108(7):2307-15.
2005: Huazhang An; Hongmei Xu; Minghui Zhang; Jun Zhou; Tao Feng; Cheng Qian; Runzi Qi; Xuetao Cao
Src homology 2 domain-containing inositol-5-phosphatase 1 (SHIP1) negatively regulates TLR4-mediated LPS response primarily through a phosphatase activity- and PI-3K-independent mechanism.
Blood 2005;105(12):4685-92.
2004: Minghui Zhang; Hua Tang; Zhenhong Guo; Huazhang An; Xuejun Zhu; Wengang Song; Jun Guo; Xin Huang; Taoyong Chen; Jianli Wang; Xuetao Cao
Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells.
Nature immunology 2004;5(11):1124-33.
2004: Tao Wan; Xiangyang Zhou; Guoyou Chen; Huazhang An; Taoyong Chen; Weiping Zhang; Shuxun Liu; Yingming Jiang; Feng Yang; Yanfeng Wu; Xuetao Cao
Novel heat shock protein Hsp70L1 activates dendritic cells and acts as a Th1 polarizing adjuvant.
Blood 2004;103(5):1747-54.
2003: Zhenhong Guo; Minghui Zhang; Huazhang An; Weilin Chen; Shuxun Liu; Jun Guo; Yizhi Yu; Xuetao Cao
Fas ligation induces IL-1beta-dependent maturation and IL-1beta-independent survival of dendritic cells: different roles of ERK and NF-kappaB signaling pathways.
Blood 2003;102(13):4441-7.
2003: Runzi Qi; Huazhang An; Yizhi Yu; Minghui Zhang; Shuxun Liu; Hongmei Xu; Zhenghong Guo; Tao Cheng; Xuetao Cao
Notch1 signaling inhibits growth of human hepatocellular carcinoma through induction of cell cycle arrest and apoptosis.
Cancer research 2003;63(23):8323-9.
2003: Jun Guo; Taoyong Chen; Baocheng Wang; Minghui Zhang; Huazhang An; Zhenhong Guo; Yizhi Yu; Zhihai Qin; Xuetao Cao
Chemoattraction, adhesion and activation of natural killer cells are involved in the antitumor immune response induced by fractalkine/CX3CL1.
Immunology letters 2003;89(1):1-7.
2003: Hongmei Xu; Huazhang An; Yizhi Yu; Minghui Zhang; Runzi Qi; Xuetao Cao
Ras participates in CpG oligodeoxynucleotide signaling through association with toll-like receptor 9 and promotion of interleukin-1 receptor-associated kinase/tumor necrosis factor receptor-associated factor 6 complex formation in macrophages.
The Journal of biological chemistry 2003;278(38):36334-40.
2003: Shuxun Liu; Yizhi Yu; Huazhang An; Nan Li; Naisong Lin; Wenya Wang; Weiping Zhang; Tao Wan; Xuetao Cao
Cloning and identification of a novel ubiquitin-like protein, BMSC-UbP, from human bone marrow stromal cells.
Immunology letters 2003;86(2):169-75.
2003: Shuxun Liu; Huazhang An; Nan Li; Yizhi Yu; Naisong Lin; Tao Wan; Minghui Zhang; Wenya Wang; Xuetao Cao
Cloning and identification of a novel human ubiquitin-like protein, DC-UbP, from dendritic cells.
Biochemical and biophysical research communications 2003;300(3):800-5.
2002: Huazhang An; Yizhi Yu; Minghui Zhang; Hongmei Xu; Runzi Qi; Xiaoyi Yan; Shuxun Liu; Wenya Wang; Zhenghong Guo; Jun Guo; Zhihai Qin; Xuetao Cao
Involvement of ERK, p38 and NF-kappaB signal transduction in regulation of TLR2, TLR4 and TLR9 gene expression induced by lipopolysaccharide in mouse dendritic cells.
Immunology 2002;106(1):38-45.
2002: Huazhang An; Hongmei Xu; Yizhi Yu; Minghui Zhang; Runzi Qi; Xiaoyi Yan; Shuxun Liu; Wenya Wang; Zhenghong Guo; Zhihai Qin; Xuetao Cao
Up-regulation of TLR9 gene expression by LPS in mouse macrophages via activation of NF-kappaB, ERK and p38 MAPK signal pathways.
Immunology letters 2002;81(3):165-9.
2002: Yizhi Yu; Ling Tang; Jianli Wang; Shuxun Liu; Wengya Wang; Huazhang An; Runzi Qi; Minghui Zhang; Xuetao Cao
Psoriatic lesional keratinocytes promote the maturation of human monocyte-derived Langerhans cells.
Dermatology (Basel, Switzerland) 2002;204(2):94-9.