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Jan Wouter Drijfhout

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Eliane C M Zeestraten; Jan Wouter Drijfhout; Lorraine M Fathers; Hans Gelderblom; Rogier Jongen; Ellen Kapiteijn; Peter Kuppen; Hans W Nijman; Jaap Oostendorp; Sepideh Saadatmand; Frank M Speetjens; Linda F M Stynenbosch; Rob Valentijn; Cornelis J H van de Velde; Sjoerd H van der burg; Marij J P Welters; Cornelis J M Melief
Addition of interferon-α to the p53-SLP® vaccine results in increased production of interferon-γ in vaccinated colorectal cancer patients: a phase I/II clinical trial.
Jing Shi; Leendert A Trouw; Peter A van Veelen; Annemieke J Willemze; Anthony Cerami; Jan Wouter Drijfhout; Tom W J Huizinga; George M C Janssen; René E Toes
Recognition of citrullinated and carbamylated proteins by human antibodies: specificity, cross-reactivity and the 'AMC-Senshu' method.
Renee Vermeij; Rinze Wolf; Jaap Oostendorp; Anna K L Reyners; Sjoerd H van der burg; Ate G J van der Zee; Joost Bart; Toos Daemen; Jan Wouter Drijfhout; Ineke L E Hamming; Harry Hollema; Baukje Nynke Hoogeboom; Ninke Leffers; Cornelis J Melief; Barbara H W Molmans; Hans W Nijman
Potentiation of a p53-SLP vaccine by cyclophosphamide in ovarian cancer: a single-arm phase II study.

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All Publications

2013: Eliane C M Zeestraten; Jan Wouter Drijfhout; Lorraine M Fathers; Hans Gelderblom; Rogier Jongen; Ellen Kapiteijn; Peter Kuppen; Hans W Nijman; Jaap Oostendorp; Sepideh Saadatmand; Frank M Speetjens; Linda F M Stynenbosch; Rob Valentijn; Cornelis J H van de Velde; Sjoerd H van der burg; Marij J P Welters; Cornelis J M Melief
Addition of interferon-α to the p53-SLP® vaccine results in increased production of interferon-γ in vaccinated colorectal cancer patients: a phase I/II clinical trial.
International journal of cancer. Journal international du cancer 2013;132(7):1581-91.
2013: Jing Shi; Leendert A Trouw; Peter A van Veelen; Annemieke J Willemze; Anthony Cerami; Jan Wouter Drijfhout; Tom W J Huizinga; George M C Janssen; René E Toes
Recognition of citrullinated and carbamylated proteins by human antibodies: specificity, cross-reactivity and the 'AMC-Senshu' method.
Annals of the rheumatic diseases 2013;72(1):148-50.
2012: Renee Vermeij; Rinze Wolf; Jaap Oostendorp; Anna K L Reyners; Sjoerd H van der burg; Ate G J van der Zee; Joost Bart; Toos Daemen; Jan Wouter Drijfhout; Ineke L E Hamming; Harry Hollema; Baukje Nynke Hoogeboom; Ninke Leffers; Cornelis J Melief; Barbara H W Molmans; Hans W Nijman
Potentiation of a p53-SLP vaccine by cyclophosphamide in ovarian cancer: a single-arm phase II study.
International journal of cancer. Journal international du cancer 2012;131(5):E670-80.
2012: Fernanda V Castro; Jan Wouter Drijfhout; David Gilham; Hui-Rong Jiang; Milena Kalaitsidou; Kate Mulryan; Andrzej J Rutkowski; Sumia Ali; Mariam Al-Muftah; Peter L Stern
Regulation of autologous immunity to the mouse 5T4 oncofoetal antigen: implications for immunotherapy.
Cancer immunology, immunotherapy : CII 2012;61(7):1005-18.
2012: Hanna E Lindfors; Jan Wouter Drijfhout; Marcellus Ubbink
The Src SH2 domain interacts dynamically with the focal adhesion kinase binding site as demonstrated by paramagnetic NMR spectroscopy.
IUBMB life 2012;64(6):538-44.
2012: Nadine van Montfoort; Sjef Verbeek; Ingrid E C Verhaart; Ari Waisman; Marcel Camps; Jan Wouter Drijfhout; Sara M Mangsbo; Cornelis J M Melief; Wendy W C van Maren; Ferry Ossendorp
Circulating specific antibodies enhance systemic cross-priming by delivery of complexed antigen to dendritic cells in vivo.
European journal of immunology 2012;42(3):598-606.
2012: Wendy W J Unger; Arno R van der Slik; Dave V Serreze; Leonard D Shultz; Joana R F Abreu; Sacha Mulder-van der Kracht; Jan Wouter Drijfhout; Dale L Greiner; Marieke Griffioen; Michel Kester; Sandra Laban; Todd Pearson; Bart O Roep
Islet-specific CTL cloned from a type 1 diabetes patient cause beta-cell destruction after engraftment into HLA-A2 transgenic NOD/scid/IL2RG null mice.
PloS one 2012;7(11):e49213.
2011: Yvonne Kooy-Winkelaar; M Luisa Mearin; Antonis K Moustakas; Chris J Mulder; George K Papadopoulos; Bart O Roep; Joachim Schweizer; Jeroen Van Bergen; Menno van Lummel; Jan Wouter Drijfhout; Frits Koning
Gluten-specific T cells cross-react between HLA-DQ8 and the HLA-DQ2α/DQ8β transdimer.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(10):5123-9.
2011: wendy unger; Jurjen H L Velthuis; Schumacher Ton; Joana R F Abreu; Arnold H Bakker; Jan Wouter Drijfhout; Gaby Duinkerken; Kees L M C Franken; Robert Hilbrands; Michel Kester; Bart Keymeulen; Sandra Laban; Arend Mulder; Ferry Ossendorp; Mark Peakman; Edwin Quinten; Sine Reker-Hadrup; Bart O Roep
Discovery of low-affinity preproinsulin epitopes and detection of autoreactive CD8 T-cells using combinatorial MHC multimers.
Journal of autoimmunity 2011;37(3):151-9.
2011: Susanna Commandeur; Krista E van Meijgaarden; May Young Lin; Kees L M C Franken; Annemieke H Friggen; Jan Wouter Drijfhout; Fredrik Oftung; Gro Ellen Korsvold; Annemieke Geluk; Tom H M Ottenhoff
Identification of human T-cell responses to Mycobacterium tuberculosis resuscitation-promoting factors in long-term latently infected individuals.
Clinical and vaccine immunology : CVI 2011;18(4):676-83.
2011: Marieke C Verweij; Maaike E Ressing; Wilco Knetsch; Edwin Quinten; Anne Halenius; Nikki van Bel; Hartmut Hengel; Jan Wouter Drijfhout; Thorbald van Hall; Emmanuel J H J Wiertz
Inhibition of mouse TAP by immune evasion molecules encoded by non-murine herpesviruses.
Molecular immunology 2011;48(6-7):835-45.
2011: Hanna E Lindfors; Bharat Somireddy Venkata; Jan Wouter Drijfhout; Marcellus Ubbink
Linker length dependent binding of a focal adhesion kinase derived peptide to the Src SH3-SH2 domains.
FEBS letters 2011;585(4):601-5.
2011: P Suwannalai; H U Scherer; D van der Woude; Andreea Ioan-Facsinay; CM Jol-van der Zijde; Maarten J D van Tol; Jan Wouter Drijfhout; T W J Huizinga; René E M Toes; Leendert A Trouw
Anti-citrullinated protein antibodies have a low avidity compared with antibodies against recall antigens.
Annals of the rheumatic diseases 2011;70(2):373-9.
2011: Parawee Suwannalai; Jan Wouter Drijfhout; Nivine Levarht; Gerrie Stoeken-Rijsbergen; Linda van Toorn; Annemiek Willemze; Tom W J Huizinga; Rene E M Toes; Leendert A Trouw
The fine specificity of IgM anti-citrullinated protein antibodies (ACPA) is different from that of IgG ACPA.
Arthritis research & therapy 2011;13(6):R195.
2010: Muriel van den Hende; Anke Redeker; Kitty M C Kwappenberg; Kees L M C Franken; Jan Wouter Drijfhout; Jaap Oostendorp; Rob Valentijn; Loraine M Fathers; Marij J P Welters; Cornelis J M Melief; Gemma G Kenter; Sjoerd H van der burg; Rienk Offringa
Evaluation of immunological cross-reactivity between clade A9 high-risk human papillomavirus types on the basis of E6-Specific CD4+ memory T cell responses.
The Journal of infectious diseases 2010;202(8):1200-11.
2010: Diane van der Woude; Solbritt Rantapää-Dahlqvist; Andreea Ioan-Facsinay; Carla Onnekink; Carla M Schwarte; Kirsten N Verpoort; Jan Wouter Drijfhout; Tom W J Huizinga; René E M Toes; Ger J M Pruijn
Epitope spreading of the anti-citrullinated protein antibody response occurs before disease onset and is associated with the disease course of early arthritis.
Annals of the rheumatic diseases 2010;69(8):1554-61.
2010: Jurjen H Velthuis; wendy unger; Joana R F Abreu; Gaby Duinkerken; Kees Franken; Mark Peakman; Arnold H Bakker; Sine Reker-Hadrup; Bart Keymeulen; Jan Wouter Drijfhout; Ton N Schumacher; Bart O Roep
Simultaneous detection of circulating autoreactive CD8+ T-cells specific for different islet cell-associated epitopes using combinatorial MHC multimers.
Diabetes 2010;59(7):1721-30.
2010: Marij J P Welters; Gemma G Kenter; Peggy J de Vos van Steenwijk; Margriet J G Löwik; Dorien M A Berends-van der Meer; Farah Essahsah; Linda F M Stynenbosch; Annelies P G Vloon; Tamara H Ramwadhdoebe; Sytse J Piersma; Jeanette M van der Hulst; Rob Valentijn; Lorraine M Fathers; Jan Wouter Drijfhout; Kees L M C Franken; Jaap Oostendorp; Gert Jan Fleuren; Cornelis J M Melief; Sjoerd H van der burg
Success or failure of vaccination for HPV16-positive vulvar lesions correlates with kinetics and phenotype of induced T-cell responses.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(26):11895-9.
2010: Cristina Mitea; Elma M J Salentijn; Peter van Veelen; Svetlana V Goryunova; Ingrid M van der Meer; Hetty C van den Broeck; Jorge R Mujico; Veronica Monserrat; Luud J W J Gilissen; Jan Wouter Drijfhout; Liesbeth Dekking; Frits Koning; Veronica Montserrat; Marinus Smulders
A universal approach to eliminate antigenic properties of alpha-gliadin peptides in celiac disease.
PloS one 2010;5(12):e15637.
2010: Anouk L Feitsma; Ellen I H van der Voort; Kees L M C Franken; Hanane el Bannoudi; Berendina G Elferink; Jan Wouter Drijfhout; Tom W J Huizinga; René R P De Vries; René E M Toes; A Ioan-Facsinay
Identification of citrullinated vimentin peptides as T cell epitopes in HLA-DR4-positive patients with rheumatoid arthritis.
Arthritis and rheumatism 2010;62(1):117-25.
2009: Gemma G Kenter; Marij J P Welters; Rob Valentijn; Margriet J G Lowik; Dorien M A Berends-van der Meer; Annelies P G Vloon; Farah Essahsah; Lorraine M Fathers; Rienk Offringa; Jan Wouter Drijfhout; Amon R Wafelman; Jaap Oostendorp; Gert Jan Fleuren; Sjoerd H van der burg; Cornelis J M Melief
Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia.
The New England journal of medicine 2009;361(19):1838-47.
2009: Ninke Leffers; Annechien J A Lambeck; Marloes J M Gooden; Baukje Nynke Hoogeboom; Rinze Wolf; Ineke E Hamming; Bouke G Hepkema; Pax H B Willemse; Barbara H W Molmans; Harry Hollema; Jan Wouter Drijfhout; Willem J Sluiter; Rob Valentijn; Loraine M Fathers; Jaap Oostendorp; Ate G J van der Zee; Cornelis J Melief; Sjoerd H van der burg; Toos Daemen; Hans W Nijman
Immunization with a P53 synthetic long peptide vaccine induces P53-specific immune responses in ovarian cancer patients, a phase II trial.
International journal of cancer. Journal international du cancer 2009;125(9):2104-13.
2009: Eyad Elkord; Adam Dangoor; Deborah J Burt; Thomas D Southgate; Sai Daayana; Richard Harrop; Jan Wouter Drijfhout; David Sherlock; Robert E Hawkins; Peter L Stern
Immune evasion mechanisms in colorectal cancer liver metastasis patients vaccinated with TroVax (MVA-5T4).
Cancer immunology, immunotherapy : CII 2009;58(10):1657-67.
2009: Eric Spierings; Stéphanie Gras; Jean-Baptiste Reiser; Bregje Mommaas; Mathilde Almekinders; Michel Kester; Anne Chouquet; Madalen Le Gorrec; Jan Wouter Drijfhout; Ferry Ossendorp; Dominique Housset; Els Goulmy
Steric hindrance and fast dissociation explain the lack of immunogenicity of the minor histocompatibility HA-1Arg Null allele.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(8):4809-16.
2009: Frank M Speetjens; Peter J K Kuppen; Marij J P Welters; Farah Essahsah; Anne Marie E G Voet van den Brink; M Graziella Kallenberg Lantrua; Rob Valentijn; Jaap Oostendorp; Lorraine M Fathers; Hans W Nijman; Jan Wouter Drijfhout; Cornelis J H van de Velde; Cornelis J M Melief; Sjoerd H van der burg
Induction of p53-specific immunity by a p53 synthetic long peptide vaccine in patients treated for metastatic colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(3):1086-95.
2009: Jimmy J Weterings; Selina Khan; Jan Wouter Drijfhout; Ferry Ossendorp; Herman S Overkleeft; Gijsbert A van der Marel; Dmitri V Filippov
Synthesis of modified and hybrid protein derived biopolymers.
Advances in experimental medicine and biology 2009;611():141-2.
2008: Eyad Elkord; Adam Dangoor; Noel L Drury; Richard Harrop; Deborah J Burt; Jan Wouter Drijfhout; Caroline Hamer; Danielle Andrews; Stuart Naylor; David Sherlock; Robert E Hawkins; Peter L Stern
An MVA-based vaccine targeting the oncofetal antigen 5T4 in patients undergoing surgical resection of colorectal cancer liver metastases.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2008;31(9):820-9.
2008: Cristina Mitea; Yvonne Kooy-Winkelaar; Peter van Veelen; Arnoud de Ru; Jan Wouter Drijfhout; Frits Koning; Liesbeth Dekking
Fine specificity of monoclonal antibodies against celiac disease-inducing peptides in the gluteome.
The American journal of clinical nutrition 2008;88(4):1057-66.
2008: Martina Wiesner; Dariusz Stepniak; Arnoud de Ru; Antonis K Moustakis; Jan Wouter Drijfhout; George K Papadopoulos; Peter van Veelen; Frits Koning
Dominance of an alternative CLIP sequence in the celiac disease associated HLA-DQ2 molecule.
Immunogenetics 2008;60(9):551-5.
2008: Hanna E Lindfors; Peter E de Koning; Jan Wouter Drijfhout; Brigida Venezia; Marcellus Ubbink
Mobility of TOAC spin-labelled peptides binding to the Src SH3 domain studied by paramagnetic NMR.
Journal of biomolecular NMR 2008;41(3):157-67.
2008: Junda M Kel; Bram Slütter; Jan Wouter Drijfhout; Frits Koning; Lex Nagelkerken
Mannosylated self-peptide inhibits the development of experimental autoimmune encephalomyelitis via expansion of nonencephalitogenic T cells.
Journal of leukocyte biology 2008;84(1):182-90.
2008: Muriel van den Hende; Mariëtte I E Van Poelgeest; Jeanette M van der Hulst; J de Jong; Jan Wouter Drijfhout; Gert Jan Fleuren; Rob Valentijn; Amon R Wafelman; Gijs M Slappendel; Cornelis J M Melief; Rienk Offringa; Sjoerd H van der burg; Gemma G Kenter
Skin reactions to human papillomavirus (HPV) 16 specific antigens intradermally injected in healthy subjects and patients with cervical neoplasia.
International journal of cancer. Journal international du cancer 2008;123(1):146-52.
2008: Eyad Elkord; Deborah J Burt; Jan Wouter Drijfhout; Robert E Hawkins; Peter L Stern
CD4+ T-cell recognition of human 5T4 oncofoetal antigen: implications for initial depletion of CD25+ T cells.
Cancer immunology, immunotherapy : CII 2008;57(6):833-47.
2008: Dariusz Stepniak; Martina Wiesner; Arnoud de Ru; Antonis K Moustakas; Jan Wouter Drijfhout; George K Papadopoulos; Peter van Veelen; Frits Koning
Large-scale characterization of natural ligands explains the unique gluten-binding properties of HLA-DQ2.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(5):3268-78.
2008: Annemieke Geluk; JD van der Ploeg; Rose O B Teles; Kees L M C Franken; Corine Prins; Jan Wouter Drijfhout; Euzenir N Sarno; Elizabeth P Sampaio; Tom H M Ottenhoff
Rational combination of peptides derived from different Mycobacterium leprae proteins improves sensitivity for immunodiagnosis of M. leprae infection.
Clinical and vaccine immunology : CVI 2008;15(3):522-33.
2008: Marij J P Welters; Gemma G Kenter; Sytse J Piersma; Annelies P G Vloon; Margriet J G Löwik; Dorien M A Berends-van der Meer; Jan Wouter Drijfhout; Rob Valentijn; Amon R Wafelman; Jaap Oostendorp; Gert Jan Fleuren; Rienk Offringa; Cornelis J M Melief; Sjoerd H van der burg
Induction of tumor-specific CD4+ and CD8+ T-cell immunity in cervical cancer patients by a human papillomavirus type 16 E6 and E7 long peptides vaccine.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(1):178-87.
2008: Gemma G Kenter; Marij J P Welters; Rob Valentijn; Margriet J G Lowik; Dorien M A Berends-van der Meer; Annelies P G Vloon; Jan Wouter Drijfhout; Amon R Wafelman; Jaap Oostendorp; Gert Jan Fleuren; Rienk Offringa; Sjoerd H van der burg; Cornelis J M Melief
Phase I immunotherapeutic trial with long peptides spanning the E6 and E7 sequences of high-risk human papillomavirus 16 in end-stage cervical cancer patients shows low toxicity and robust immunogenicity.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(1):169-77.
2008: Junda M Kel; Eveline De Geus; Marianne J van Stipdonk; Jan Wouter Drijfhout; Frits Koning; Lex Nagelkerken
Immunization with mannosylated peptide induces poor T cell effector functions despite enhanced antigen presentation.
International immunology 2008;20(1):117-27.
2007: Kirsten N Verpoort; K Cheung; Andreea Ioan-Facsinay; Annette H M Van Der Helm-Van Mil; Jeska K de Vries-Bouwstra; Cornelia F Allaart; Jan Wouter Drijfhout; René R P De Vries; Ferdinand C Breedveld; Tom W J Huizinga; Ger J M Pruijn; René E M Toes
Fine specificity of the anti-citrullinated protein antibody response is influenced by the shared epitope alleles.
Arthritis and rheumatism 2007;56(12):3949-52.
2007: Albert J W Zendman; Reinout Raijmakers; Suzanne Nijenhuis; Erik R Vossenaar; Marloes van den Tillaart; Renato G S Chirivi; Jos M H Raats; Walther J van Venrooij; Jan Wouter Drijfhout; Ger J M Pruijn
ABAP: antibody-based assay for peptidylarginine deiminase activity.
Analytical biochemistry 2007;369(2):232-40.
2007: Kirsten N Verpoort; E A M Papendrecht-van der Voort; Annette H M Van Der Helm-Van Mil; CM Jol-van der Zijde; Maarten J D van Tol; Jan Wouter Drijfhout; Ferdinand C Breedveld; René R P De Vries; Tom W J Huizinga; René E M Toes
Association of smoking with the constitution of the anti-cyclic citrullinated peptide response in the absence of HLA-DRB1 shared epitope alleles.
Arthritis and rheumatism 2007;56(9):2913-8.
2007: Annechien J A Lambeck; Ninke Leffers; Baukje Nynke Hoogeboom; Wim Sluiter; Ineke Hamming; Harry Klip; Klaske A ten Hoor; Martha Esajas; Magda van Oven; Jan Wouter Drijfhout; Inge Platteel; Rienk Offringa; Harry Hollema; Kees Melief; Sjoerd H van der burg; Ate van der Zee; Toos Daemen; Hans W Nijman
P53-specific T cell responses in patients with malignant and benign ovarian tumors: implications for p53 based immunotherapy.
International journal of cancer. Journal international du cancer 2007;121(3):606-14.
2007: Selina Khan; Martijn Bijker; Jimmy J Weterings; Hans J Tanke; Gosse J Adema; Thorbald van Hall; Jan Wouter Drijfhout; Cornelis J M Melief; Herman S Overkleeft; Gijsbert A van der Marel; Dmitri V Filippov; Sjoerd H van der burg; Ferry Ossendorp
Distinct uptake mechanisms but similar intracellular processing of two different toll-like receptor ligand-peptide conjugates in dendritic cells.
The Journal of biological chemistry 2007;282(29):21145-59.
2007: Tom Groeneveld; Tamara H Ramwadhdoebé; Leendert A Trouw; Dafne L van den Ham; Vanessa van der Borden; Jan Wouter Drijfhout; Pieter S Hiemstra; Mohamed R Daha; Anja Roos
Human neutrophil peptide-1 inhibits both the classical and the lectin pathway of complement activation.
Molecular immunology 2007;44(14):3608-14.
2007: Wolfgang Hueber; Beren H Tomooka; XIAOYAN ZHAO; Brian A Kidd; Jan Wouter Drijfhout; James F Fries; Walther J van Venrooij; Allan L Metzger; Mark C Genovese; William H Robinson
Proteomic analysis of secreted proteins in early rheumatoid arthritis: anti-citrulline autoreactivity is associated with up regulation of proinflammatory cytokines.
Annals of the rheumatic diseases 2007;66(6):712-9.
2007: Reinout Raijmakers; Albert J W Zendman; Wilma Vree Egberts; Erik R Vossenaar; Jos M H Raats; Claudia Soede-Huijbregts; Floris P J T Rutjes; Peter A van Veelen; Jan Wouter Drijfhout; Ger J M Pruijn
Methylation of arginine residues interferes with citrullination by peptidylarginine deiminases in vitro.
Journal of molecular biology 2007;367(4):1118-29.
2007: wendy unger; Gabrielle G M Pinkse; S Mulder-van der Kracht; Arno R van der Slik; Michel Kester; Ferry Ossendorp; Jan Wouter Drijfhout; D V Serreze; Bart O Roep
Human clonal CD8 autoreactivity to an IGRP islet epitope shared between mice and men.
Annals of the New York Academy of Sciences 2007;1103():192-5.
2007: Sytse J Piersma; Ekaterina S. Jordanova; Mariëtte I E Van Poelgeest; Kitty M C Kwappenberg; Jeanette M van der Hulst; Jan Wouter Drijfhout; Cornelis J M Melief; Gemma G Kenter; Gert Jan Fleuren; Rienk Offringa; Sjoerd H van der burg
High number of intraepithelial CD8+ tumor-infiltrating lymphocytes is associated with the absence of lymph node metastases in patients with large early-stage cervical cancer.
Cancer research 2007;67(1):354-61.
2007: Junda M Kel; Judith Oldenampsen; Mariken E Luca; Jan Wouter Drijfhout; Frits Koning; Lex Nagelkerken
Soluble mannosylated myelin peptide inhibits the encephalitogenicity of autoreactive T cells during experimental autoimmune encephalomyelitis.
The American journal of pathology 2007;170(1):272-80.
2006: Kirsten N Verpoort; CM Jol-van der Zijde; E A M Papendrecht-van der Voort; Andreea Ioan-Facsinay; Jan Wouter Drijfhout; Maarten J D van Tol; Ferdinand C Breedveld; Tom W J Huizinga; René E M Toes
Isotype distribution of anti-cyclic citrullinated peptide antibodies in undifferentiated arthritis and rheumatoid arthritis reflects an ongoing immune response.
Arthritis and rheumatism 2006;54(12):3799-808.
2006: Jan H. Kessler; S A Bres-Vloemans; Peter van Veelen; Arnoud de Ru; Ivo Huijbers; Marcel Camps; Arend Mulder; Rienk Offringa; Jan Wouter Drijfhout; OC Leeksma; Ferry Ossendorp; Cornelis J M Melief
BCR-ABL fusion regions as a source of multiple leukemia-specific CD8+ T-cell epitopes.
Leukemia 2006;20(10):1738-50.
2006: Lucy J C Smyth; Eyad Elkord; Taher E I Taher; Hui-Rong Jiang; Deborah J Burt; Alison Clayton; Peter van Veelen; Arnoud de Ru; Ferry Ossendorp; Cornelis J M Melief; Jan Wouter Drijfhout; Said Dermime; Robert E Hawkins; Peter L Stern
CD8 T-cell recognition of human 5T4 oncofetal antigen.
International journal of cancer. Journal international du cancer 2006;119(7):1638-47.
2006: Danny Van Aken; Willemien Benckhuijsen; Jan Wouter Drijfhout; Fred Wassenaar; Alexander E Gorbalenya; Eric J Snijder
Expression, purification, and in vitro activity of an arterivirus main proteinase.
Virus research 2006;120(1-2):97-106.
2006: Ivana Durinovic-Belló; Silke Rosinger; Jennifer A Olson; Mauro Congia; Regina C Ahmad; Mathias Rickert; Johannes Hampl; Hubert Kalbacher; Jan Wouter Drijfhout; Elizabeth D Mellins; Sascha Al Dahouk; Thomas Kamradt; Markus J Maeurer; Carol Nhan; Bart O Roep; Bernhard O Boehm; Constantin Polychronakos; Gerald Nepom; Wolfram Karges; Hugh McDevitt; Grete Sønderstrup
DRB1*0401-restricted human T cell clone specific for the major proinsulin73-90 epitope expresses a down-regulatory T helper 2 phenotype.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(31):11683-8.
2006: John Frater; Charles T T Edwards; N McCarthy; Julie Fox; Helen Brown; Anita Milicic; Nicola E Mackie; Tilly Pillay; Jan Wouter Drijfhout; Simon Dustan; John R Clarke; Edward C Holmes; Hua-Tang Zhang; Katja Pfafferott; Philip J R Goulder; Myra O McClure; Jonathan Weber; Rodney E Phillips; Sarah Fidler
Passive sexual transmission of human immunodeficiency virus type 1 variants and adaptation in new hosts.
Journal of virology 2006;80(14):7226-34.
2006: Jimmy J Weterings; Selina Khan; Gerbrand J van der Heden; Jan Wouter Drijfhout; Cornelis J M Melief; Herman S Overkleeft; Sjoerd H van der burg; Ferry Ossendorp; Gijsbert A van der Marel; Dmitri V Filippov
Synthesis of 2-alkoxy-8-hydroxyadenylpeptides: towards synthetic epitope-based vaccines.
Bioorganic & medicinal chemistry letters 2006;16(12):3258-61.
2006: Thorbald van Hall; Elisabeth Z Wolpert; Peter van Veelen; Sandra Laban; Michael van der Veer; Marjet Roseboom; Sandra A Bres; Per Grufman; Arnoud de Ru; Hugo D Meiring; Annemieke de Jong; Kees L M C Franken; Antoinette Teixeira; Rob Valentijn; Jan Wouter Drijfhout; Frits Koning; Marcel Camps; Ferry Ossendorp; Klas Kärre; Hans-Gustaf Ljunggren; Cornelis J M Melief; Rienk Offringa
Selective cytotoxic T-lymphocyte targeting of tumor immune escape variants.
Nature medicine 2006;12(4):417-24.
2006: Marja J Nell; G Sandra Tjabringa; Amon R Wafelman; Ruud Verrijk; Pieter S Hiemstra; Jan Wouter Drijfhout; Jan J Grote
Development of novel LL-37 derived antimicrobial peptides with LPS and LTA neutralizing and antimicrobial activities for therapeutic application.
Peptides 2006;27(4):649-60.
2006: Carla A Herberts; Joost Neijssen; Jolanda de Haan; Lennert Janssen; Jan Wouter Drijfhout; Eric Reits; Jacques Neefjes
Cutting edge: HLA-B27 acquires many N-terminal dibasic peptides: coupling cytosolic peptide stability to antigen presentation.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(5):2697-701.
2006: Marij J P Welters; Pauline van der Logt; Susan J F van den Eeden; Kitty M C Kwappenberg; Jan Wouter Drijfhout; Gert Jan Fleuren; Gemma G Kenter; Cornelis J M Melief; Sjoerd H van der burg; Rienk Offringa
Detection of human papillomavirus type 18 E6 and E7-specific CD4+ T-helper 1 immunity in relation to health versus disease.
International journal of cancer. Journal international du cancer 2006;118(4):950-6.
2006: G Sandra Tjabringa; Dennis K Ninaber; Jan Wouter Drijfhout; Klaus F Rabe; Pieter S Hiemstra
Human cathelicidin LL-37 is a chemoattractant for eosinophils and neutrophils that acts via formyl-peptide receptors.
International archives of allergy and immunology 2006;140(2):103-12.
2005: Gabrielle G M Pinkse; Odette H M Tysma; Cees A M Bergen; Michel Kester; Ferry Ossendorp; Peter van Veelen; Bart Keymeulen; Daniel Pipeleers; Jan Wouter Drijfhout; Bart O Roep
Autoreactive CD8 T cells associated with beta cell destruction in type 1 diabetes.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(51):18425-30.
2005: Anita Milicic; Charles T T Edwards; Stéphane Hué; Julie Fox; Helen Brown; Tilly Pillay; Jan Wouter Drijfhout; Jonathan N Weber; Edward C Holmes; Sarah Fidler; Hua-Tang Zhang; Rodney E Phillips
Sexual transmission of single human immunodeficiency virus type 1 virions encoding highly polymorphic multisite cytotoxic T-lymphocyte escape variants.
Journal of virology 2005;79(22):13953-62.
2005: Arend Mulder; Chantal Eijsink; Michel Kester; Marry E I Franke; Marrie J Kardol; Mirjam H M Heemskerk; Cees van Kooten; Frank A W Verreck; Jan Wouter Drijfhout; Frits Koning; Ilias Doxiadis; Frans H J Claas
Impact of peptides on the recognition of HLA class I molecules by human HLA antibodies.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(9):5950-7.
2005: Liesbeth Spaenij-Dekking; Yvonne Kooy-Winkelaar; Peter van Veelen; Jan Wouter Drijfhout; Harry Jonker; Loek van Soest; Marinus Smulders; Dirk Bosch; Luud J W J Gilissen; Frits Koning
Natural variation in toxicity of wheat: potential for selection of nontoxic varieties for celiac disease patients.
Gastroenterology 2005;129(3):797-806.
2005: Wolfgang Hueber; Brian A Kidd; Beren H Tomooka; Byung J Lee; Bonnie Bruce; James F Fries; Grete Sønderstrup; Paul A Monach; Jan Wouter Drijfhout; Walther J van Venrooij; Paul J Utz; Mark C Genovese; William H Robinson
Antigen microarray profiling of autoantibodies in rheumatoid arthritis.
Arthritis and rheumatism 2005;52(9):2645-55.
2005: Tilly Pillay; Hua-Tang Zhang; Jan Wouter Drijfhout; Nicola Robinson; Helen Brown; Munira Khan; Jack Moodley; Miriam Adhikari; Katja Pfafferott; Margaret E Feeney; Anne St John; Edward C Holmes; Hoosen M Coovadia; Paul Klenerman; Philip J R Goulder; Rodney E Phillips
Unique acquisition of cytotoxic T-lymphocyte escape mutants in infant human immunodeficiency virus type 1 infection.
Journal of virology 2005;79(18):12100-5.
2005: Mariëtte I E Van Poelgeest; Manon van Seters; Marc van Beurden; Kitty M C Kwappenberg; Claudia Heijmans-Antonissen; Jan Wouter Drijfhout; Cornelis J M Melief; Gemma G Kenter; Theo J M Helmerhorst; Rienk Offringa; Sjoerd H van der burg
Detection of human papillomavirus (HPV) 16-specific CD4+ T-cell immunity in patients with persistent HPV16-induced vulvar intraepithelial neoplasia in relation to clinical impact of imiquimod treatment.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(14):5273-80.
2005: Aude E Duquesne; Martina de Ruijter; Jaap Brouwer; Jan Wouter Drijfhout; Sander B Nabuurs; Chris A E M Spronk; Geerten W Vuister; Marcellus Ubbink; Gerard W Canters
Solution structure of the second PDZ domain of the neuronal adaptor X11alpha and its interaction with the C-terminal peptide of the human copper chaperone for superoxide dismutase.
Journal of biomolecular NMR 2005;32(3):209-18.
2005: Dariusz Stepniak; L Willemijn Vader; Yvonne M C Kooy; Peter van Veelen; Antonis K Moustakas; Nikolaos A Papandreou; Elias Eliopoulos; Jan Wouter Drijfhout; George K Papadopoulos; Frits Koning
T-cell recognition of HLA-DQ2-bound gluten peptides can be influenced by an N-terminal proline at p-1.
Immunogenetics 2005;57(1-2):8-15.
2005: Annemieke de Jong; Jeanette M van der Hulst; Gemma G Kenter; Jan Wouter Drijfhout; Kees L M C Franken; Pieter Vermeij; Rienk Offringa; Sjoerd H van der burg; Cornelis J M Melief
Rapid enrichment of human papillomavirus (HPV)-specific polyclonal T cell populations for adoptive immunotherapy of cervical cancer.
International journal of cancer. Journal international du cancer 2005;114(2):274-82.
2005: Joost Neijssen; Carla A Herberts; Jan Wouter Drijfhout; Eric Reits; Lennert Janssen; Jacques Neefjes
Cross-presentation by intercellular peptide transfer through gap junctions.
Nature 2005;434(7029):83-8.
2004: Marij J P Welters; Dmitri V Filippov; Susan J F van den Eeden; Kees L M C Franken; Jan Nouta; Rob Valentijn; Gijsbert A van der Marel; Herman S Overkleeft; Grayson Lipford; Rienk Offringa; Cornelis J M Melief; Jacques H van Boom; Sjoerd H van der burg; Jan Wouter Drijfhout
Chemically synthesized protein as tumour-specific vaccine: immunogenicity and efficacy of synthetic HPV16 E7 in the TC-1 mouse tumour model.
Vaccine 2004;23(3):305-11.
2004: Jan H. Kessler; Willemien E Benckhuijsen; Tuna Mutis; Cornelis J M Melief; Sjoerd H van der burg; Jan Wouter Drijfhout
Competition-based cellular peptide binding assay for HLA class I.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2004;Chapter 18():Unit 18.12.
2004: Eduardus F M Posthuma; Cornelis A M van Bergen; Michel Kester; Roelof A de Paus; Peter van Veelen; Arnoud de Ru; Jan Wouter Drijfhout; Ellie G A Lurvink; Rein Willemze; J H Frederik Falkenburg
Proteosomal degradation of BCR/ABL protein can generate an HLA-A*0301-restricted peptide, but high-avidity T cells recognizing this leukemia-specific antigen were not demonstrated.
Haematologica 2004;89(9):1062-71.
2004: E H A Spaenij-Dekking; E M C Kooy-Winkelaar; Willem Nieuwenhuizen; Jan Wouter Drijfhout; Frits Koning
A novel and sensitive method for the detection of T cell stimulatory epitopes of alpha/beta- and gamma-gliadin.
Gut 2004;53(9):1267-73.
2004: Annemieke de Jong; Mariëtte I E Van Poelgeest; Jeanette M van der Hulst; Jan Wouter Drijfhout; Gert Jan Fleuren; Cornelis J M Melief; Gemma G Kenter; Rienk Offringa; Sjoerd H van der burg
Human papillomavirus type 16-positive cervical cancer is associated with impaired CD4+ T-cell immunity against early antigens E2 and E6.
Cancer research 2004;64(15):5449-55.
2004: Dik Blok; Hans I J Feitsma; Yvonne M C Kooy; Mick Welling; Ferry Ossendorp; Pieter Vermeij; Jan Wouter Drijfhout
New chelation strategy allows for quick and clean 99mTc-labeling of synthetic peptides.
Nuclear medicine and biology 2004;31(6):815-20.
2004: Eric Reits; Joost Neijssen; Carla A Herberts; Willemien Benckhuijsen; Lennert Janssen; Jan Wouter Drijfhout; Jacques Neefjes
A major role for TPPII in trimming proteasomal degradation products for MHC class I antigen presentation.
Immunity 2004;20(4):495-506.
2003: G Sandra Tjabringa; Jamil Aarbiou; Dennis K Ninaber; Jan Wouter Drijfhout; Ole E Sørensen; Niels Borregaard; Klaus F Rabe; Pieter S Hiemstra
The antimicrobial peptide LL-37 activates innate immunity at the airway epithelial surface by transactivation of the epidermal growth factor receptor.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(12):6690-6.
2003: E H A Spaenij-Dekking; J Van Delft; Els van der Meijden; HS Hiemstra; J H Frederik Falkenburg; Frits Koning; Jan Wouter Drijfhout; Johanna C Kluin-Nelemans
Synaptojanin 2 is recognized by HLA class II-restricted hairy cell leukemia-specific T cells.
Leukemia 2003;17(12):2467-73.
2003: Sjoerd H van der burg; Anand G Menon; Anke Redeker; Kees L M C Franken; Jan Wouter Drijfhout; R A E M Tollenaar; Henk H Hartgrink; Cornelis J H van de Velde; Peter Kuppen; Cornelis J M Melief; Rienk Offringa
Magnitude and polarization of P53-specific T-helper immunity in connection to leukocyte infiltration of colorectal tumors.
International journal of cancer. Journal international du cancer 2003;107(3):425-33.
2003: L Willemijn Vader; Dariusz Stepniak; Evelien M Bunnik; Yvonne M C Kooy; Willeke de Haan; Jan Wouter Drijfhout; Peter van Veelen; Frits Koning
Characterization of cereal toxicity for celiac disease patients based on protein homology in grains.
Gastroenterology 2003;125(4):1105-13.
2003: W A Erik Marijt; Mirjam H M Heemskerk; Freke M Kloosterboer; Els Goulmy; Michel Kester; Menno A W G van der Hoorn; Simone A P van Luxemburg-Heys; Manja Hoogeboom; Tuna Mutis; Jan Wouter Drijfhout; Jon van Rood; Rein Willemze; J H Frederik Falkenburg
Hematopoiesis-restricted minor histocompatibility antigens HA-1- or HA-2-specific T cells can induce complete remissions of relapsed leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2742-7.
2003: Marij J P Welters; Annemieke de Jong; Susan J F van den Eeden; Jeanette M van der Hulst; Kitty M C Kwappenberg; Sabrin Hassane; Kees L M C Franken; Jan Wouter Drijfhout; Gert Jan Fleuren; Gemma G Kenter; Cornelis J M Melief; Rienk Offringa; Sjoerd H van der burg
Frequent display of human papillomavirus type 16 E6-specific memory t-Helper cells in the healthy population as witness of previous viral encounter.
Cancer research 2003;63(3):636-41.
2003: Jan H. Kessler; Bregje Mommaas; Tuna Mutis; Ivo Huijbers; Debby Vissers; Willemien Benckhuijsen; G M Th Schreuder; Rienk Offringa; Els Goulmy; Cornelis J M Melief; Sjoerd H van der burg; Jan Wouter Drijfhout
Competition-based cellular peptide binding assays for 13 prevalent HLA class I alleles using fluorescein-labeled synthetic peptides.
Human immunology 2003;64(2):245-55.
2003: Eric Reits; Alexander Griekspoor; Joost Neijssen; Tom A M Groothuis; Kees Jalink; Peter van Veelen; Hans Janssen; Jero Calafat; Jan Wouter Drijfhout; Jacques Neefjes
Peptide diffusion, protection, and degradation in nuclear and cytoplasmic compartments before antigen presentation by MHC class I.
Immunity 2003;18(1):97-108.
2002: A Teixeira; Willemien Benckhuijsen; P E de Koning; Rob Valentijn; Jan Wouter Drijfhout
The use of DODT as a non-malodorous scavenger in Fmoc-based peptide synthesis.
Protein and peptide letters 2002;9(5):379-85.
2002: Bregje Mommaas; Janine Kamp; Jan Wouter Drijfhout; Nico J Beekman; Ferry Ossendorp; Peter van Veelen; Joke M M den Haan; Els Goulmy; Tuna Mutis
Identification of a novel HLA-B60-restricted T cell epitope of the minor histocompatibility antigen HA-1 locus.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(6):3131-6.
2002: Willemijn Vader; Yvonne M C Kooy; Peter van Veelen; Arnoud de Ru; Diana Harris; Willemien Benckhuijsen; Amado Salvador Peña; Luisa Mearin; Jan Wouter Drijfhout; Frits Koning
The gluten response in children with celiac disease is directed toward multiple gliadin and glutenin peptides.
Gastroenterology 2002;122(7):1729-37.
2002: Sjoerd H van der burg; Anand G Menon; Anke Redeker; Marie-Claude Bonnet; Jan Wouter Drijfhout; R A E M Tollenaar; Cornelis J H van de Velde; Philippe Moingeon; Peter Kuppen; Rienk Offringa; Cornelis J M Melief
Induction of p53-specific immune responses in colorectal cancer patients receiving a recombinant ALVAC-p53 candidate vaccine.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(5):1019-27.
2002: Mario H J Vogt; Joost W van den Muijsenberg; Els Goulmy; Eric Spierings; Petra Kluck; Michel Kester; Ronald A van Soest; Jan Wouter Drijfhout; Rein Willemze; J H Frederik Falkenburg
The DBY gene codes for an HLA-DQ5-restricted human male-specific minor histocompatibility antigen involved in graft-versus-host disease.
Blood 2002;99(8):3027-32.
2002: Bart O Roep; HS Hiemstra; Nanette C Schloot; René R P De Vries; A Chaudhuri; Peter Behan; Jan Wouter Drijfhout
Molecular mimicry in type 1 diabetes: immune cross-reactivity between islet autoantigen and human cytomegalovirus but not Coxsackie virus.
Annals of the New York Academy of Sciences 2002;958():163-5.
2002: L Willemijn Vader; Arnoud de Ru; Yvonne van der Wal; Yvonne M C Kooy; Willemien Benckhuijsen; M Luisa Mearin; Jan Wouter Drijfhout; Peter van Veelen; Frits Koning
Specificity of tissue transglutaminase explains cereal toxicity in celiac disease.
The Journal of experimental medicine 2002;195(5):643-9.
2002: Annemieke de Jong; Sjoerd H van der burg; Kitty M C Kwappenberg; Jeanette M van der Hulst; Kees L M C Franken; Annemieke Geluk; Krista E van Meijgaarden; Jan Wouter Drijfhout; Gemma G Kenter; Pieter Vermeij; Cornelis J M Melief; Rienk Offringa
Frequent detection of human papillomavirus 16 E2-specific T-helper immunity in healthy subjects.
Cancer research 2002;62(2):472-9.
2001: Anja Roos; Alma J Nauta; D Broers; Maria C Faber-Krol; Leendert A Trouw; Jan Wouter Drijfhout; Mohamed R Daha
Specific inhibition of the classical complement pathway by C1q-binding peptides.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(12):7052-9.
2001: Jehad Charo; Annemieke Geluk; Maria Sundbäck; B Mirzai; Alexander Diehl; Karl-Johan Malmberg; Adnane Achour; S Huriguchi; Krista E van Meijgaarden; Jan Wouter Drijfhout; Nico J Beekman; Peter van Veelen; Ferry Ossendorp; T H Ottenhoff; Rolf Kiessling
The identification of a common pathogen-specific HLA class I A*0201-restricted cytotoxic T cell epitope encoded within the heat shock protein 65.
European journal of immunology 2001;31(12):3602-11.
2001: Gabri van der Pluijm; Bianca Sijmons; HJ Vloedgraven; Chris van Der Bent; Jan Wouter Drijfhout; Jan H Verheijen; Paul H A Quax; Marcel Karperien; Socrates E Papapoulos; Clemens W G M Löwik
Urokinase-receptor/integrin complexes are functionally involved in adhesion and progression of human breast cancer in vivo.
The American journal of pathology 2001;159(3):971-82.
2001: Nanette C Schloot; Sabine Willemen; Gaby Duinkerken; Jan Wouter Drijfhout; René R P De Vries; Bart O Roep
Molecular mimicry in type 1 diabetes mellitus revisited: T-cell clones to GAD65 peptides with sequence homology to Coxsackie or proinsulin peptides do not crossreact with homologous counterpart.
Human immunology 2001;62(4):299-309.
2001: HS Hiemstra; Nanette C Schloot; Peter van Veelen; Sabine Willemen; Kees L M C Franken; Jon van Rood; René R P De Vries; A Chaudhuri; Peter Behan; Jan Wouter Drijfhout; Bart O Roep
Cytomegalovirus in autoimmunity: T cell crossreactivity to viral antigen and autoantigen glutamic acid decarboxylase.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(7):3988-91.
2001: Sjoerd H van der burg; K de Cock; Anand G Menon; Kees L M C Franken; M Palmen; Anke Redeker; Jan Wouter Drijfhout; Peter Kuppen; Cornelis J H van de Velde; L Erdile; R A E M Tollenaar; Cornelis J M Melief; Rienk Offringa
Long lasting p53-specific T cell memory responses in the absence of anti-p53 antibodies in patients with resected primary colorectal cancer.
European journal of immunology 2001;31(1):146-55.
2000: Annemieke Geluk; Krista E van Meijgaarden; Kees L M C Franken; Jan Wouter Drijfhout; S D'Souza; A Necker; K Huygen; Tom H M Ottenhoff
Identification of major epitopes of Mycobacterium tuberculosis AG85B that are recognized by HLA-A*0201-restricted CD8+ T cells in HLA-transgenic mice and humans.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(11):6463-71.
2000: Antonis K Moustakas; Y van de Wal; J Routsias; Yvonne M C Kooy; Peter van Veelen; Jan Wouter Drijfhout; Frits Koning; George K Papadopoulos
Structure of celiac disease-associated HLA-DQ8 and non-associated HLA-DQ9 alleles in complex with two disease-specific epitopes.
International immunology 2000;12(8):1157-66.
2000: C J Hawkes; Nanette C Schloot; J Marks; Sabine Willemen; Jan Wouter Drijfhout; E K Mayer; Michael R Christie; Bart O Roep
T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes.
Diabetes 2000;49(3):356-66.
2000: HS Hiemstra; Jan Wouter Drijfhout; Bart O Roep
Antigen arrays in T cell immunology.
Current opinion in immunology 2000;12(1):80-4.
2000: Kees L M C Franken; HS Hiemstra; Krista E van Meijgaarden; Yanri W Subronto; Jan den Hartigh; Tom H M Ottenhoff; Jan Wouter Drijfhout
Purification of his-tagged proteins by immobilized chelate affinity chromatography: the benefits from the use of organic solvent.
Protein expression and purification 2000;18(1):95-9.
2000: H S Hiemstra; Jan Wouter Drijfhout; Frits Koning
Synthetic Peptide libraries for T-cell epitope identification.
Methods in molecular medicine 2000;41():89-96.
2000: Peter van Veelen; Jan Wouter Drijfhout; Frits Koning
Structure elucidation of gluten-derived peptides by tandem mass spectrometry.
Methods in molecular medicine 2000;41():75-88.
1999: Jeroen Van Bergen; Ferry Ossendorp; R Jordens; A Mieke Mommaas; Jan Wouter Drijfhout; Frits Koning
Get into the groove! Targeting antigens to MHC class II.
Immunological reviews 1999;172():87-96.
1999: Y van de Wal; Yvonne M C Kooy; Peter van Veelen; Willemijn Vader; S A August; Jan Wouter Drijfhout; Amado Salvador Peña; Frits Koning
Glutenin is involved in the gluten-driven mucosal T cell response.
European journal of immunology 1999;29(10):3133-9.
1999: HS Hiemstra; Peter van Veelen; Annemieke Geluk; Nanette C Schloot; René R P De Vries; Tom H M Ottenhoff; Bart O Roep; Jan Wouter Drijfhout
Limitations of homology searching for identification of T-cell antigens with library derived mimicry epitopes.
Vaccine 1999;18(3-4):204-8.
1999: HS Hiemstra; Peter van Veelen; Sabine Willemen; Willemien Benckhuijsen; Annemieke Geluk; René R P De Vries; Bart O Roep; Jan Wouter Drijfhout
Quantitative determination of TCR cross-reactivity using peptide libraries and protein databases.
European journal of immunology 1999;29(8):2385-91.
1999: H S de Koster; Corine Vermeulen; HS Hiemstra; R Amons; Jan Wouter Drijfhout; Frits Koning
Definition of agonists and design of antagonists for alloreactive T cell clones using synthetic peptide libraries.
International immunology 1999;11(4):585-91.
1999: Maaike E Ressing; J Hans De Jong; RM Brandt; Jan Wouter Drijfhout; Willemien Benckhuijsen; G M Th Schreuder; Rienk Offringa; W Martin Kast; Cornelis J M Melief
Differential binding of viral peptides to HLA-A2 alleles. Implications for human papillomavirus type 16 E7 peptide-based vaccination against cervical carcinoma.
European journal of immunology 1999;29(4):1292-303.
1999: Sjoerd H van der burg; Kitty M C Kwappenberg; Annemieke Geluk; M van der Kruk; Oscar Pontesilli; Egbert Hovenkamp; Kees L M C Franken; Krista E van Meijgaarden; Jan Wouter Drijfhout; Tom H M Ottenhoff; Cornelis J M Melief; Rienk Offringa
Identification of a conserved universal Th epitope in HIV-1 reverse transcriptase that is processed and presented to HIV-specific CD4+ T cells by at least four unrelated HLA-DR molecules.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(1):152-60.
1998: Monique M ten Dam; Y van de Wal; M Luisa Mearin; Yvonne M C Kooy; Amado Salvador Peña; Jan Wouter Drijfhout; Frits Koning; Maarten J D van Tol
Anti-alpha-gliadin antibodies (AGA) in the serum of coeliac children and controls recognize an identical collection of linear epitopes of alpha-gliadin.
Clinical and experimental immunology 1998;114(2):189-95.
1998: Michel P M Vierboom; Mariet C W Feltkamp; A Neisig; Jan Wouter Drijfhout; Jan ter Schegget; J J Neefjes; Cornelis J M Melief; W M Kast
Peptide vaccination with an anchor-replaced CTL epitope protects against human papillomavirus type 16-induced tumors expressing the wild-type epitope.
Journal of immunotherapy (Hagerstown, Md. : 1997) 1998;21(6):399-408.
1998: HS Hiemstra; Peter van Veelen; Nanette C Schloot; Annemieke Geluk; Krista E van Meijgaarden; Sabine Willemen; Jack Leunissen; Willemien Benckhuijsen; R Amons; René R P De Vries; Bart O Roep; Tom H M Ottenhoff; Jan Wouter Drijfhout
Definition of natural T cell antigens with mimicry epitopes obtained from dedicated synthetic peptide libraries.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(8):4078-82.
1998: Annemieke Geluk; Krista E van Meijgaarden; Nanette C Schloot; Jan Wouter Drijfhout; Tom H M Ottenhoff; Bart O Roep
HLA-DR binding analysis of peptides from islet antigens in IDDM.
Diabetes 1998;47(10):1594-601.
1998: M C Agnes; A Tan; R Jordens; Annemieke Geluk; B O Roep; Tom H M Ottenhoff; Jan Wouter Drijfhout; Frits Koning
Strongly increased efficiency of altered peptide ligands by mannosylation.
International immunology 1998;10(9):1299-304.
1998: Michel Klein; Sjoerd H van der burg; Egbert Hovenkamp; AM Holwerda; Jan Wouter Drijfhout; Cornelis J M Melief; Frank Miedema
Characterization of HLA-B57-restricted human immunodeficiency virus type 1 Gag- and RT-specific cytotoxic T lymphocyte responses.
The Journal of general virology 1998;79 ( Pt 9)():2191-201.
1998: Y van de Wal; Yvonne M C Kooy; Peter van Veelen; Amado Salvador Peña; Luisa Mearin; Oyvind Molberg; Knut E A Lundin; Ludvig M Sollid; Tuna Mutis; Willemien Benckhuijsen; Jan Wouter Drijfhout; Frits Koning
Small intestinal T cells of celiac disease patients recognize a natural pepsin fragment of gliadin.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(17):10050-4.
1998: HS Hiemstra; Willemien Benckhuijsen; R Amons; W Rapp; Jan Wouter Drijfhout
A new hybrid resin for stepwise screening of peptide libraries combined with single bead Edman sequencing.
Journal of peptide science : an official publication of the European Peptide Society 1998;4(4):282-8.
1998: René E M Toes; Ellen I H van der Voort; Stephen P Schoenberger; Jan Wouter Drijfhout; Louis van Bloois; G Storm; W Martin Kast; Rienk Offringa; Cornelis J M Melief
Enhancement of tumor outgrowth through CTL tolerization after peptide vaccination is avoided by peptide presentation on dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(9):4449-56.
1998: ML De Bruijn; Danita Schuurhuis; Michel P M Vierboom; H Vermeulen; K A de Cock; Marlies E Ooms; Maaike E Ressing; Mireille Toebes; Kees L M C Franken; Jan Wouter Drijfhout; Tom H M Ottenhoff; Rienk Offringa; Cornelis J M Melief
Immunization with human papillomavirus type 16 (HPV16) oncoprotein-loaded dendritic cells as well as protein in adjuvant induces MHC class I-restricted protection to HPV16-induced tumor cells.
Cancer research 1998;58(4):724-31.
1997: Sjoerd H van der burg; Michel Klein; Oscar Pontesilli; AM Holwerda; Jan Wouter Drijfhout; W M Kast; Frank Miedema; Cornelis J M Melief
HIV-1 reverse transcriptase-specific CTL against conserved epitopes do not protect against progression to AIDS.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(7):3648-54.
1997: HS Hiemstra; Gaby Duinkerken; Willemien Benckhuijsen; R Amons; René R P De Vries; Bart O Roep; Jan Wouter Drijfhout
The identification of CD4+ T cell epitopes with dedicated synthetic peptide libraries.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(19):10313-8.
1997: MC Tan; A Mieke Mommaas; Jan Wouter Drijfhout; R Jordens; Jos J M Onderwater; Desiree Verwoerd; Aat A Mulder; A N van der Heiden; D Scheidegger; Lauran Oomen; Tom H M Ottenhoff; A Tulp; Jacques Neefjes; Frits Koning
Mannose receptor-mediated uptake of antigens strongly enhances HLA class II-restricted antigen presentation by cultured dendritic cells.
European journal of immunology 1997;27(9):2426-35.
1997: T L Tan; Annemieke Geluk; Mireille Toebes; Tom H M Ottenhoff; Jan Wouter Drijfhout
A novel, highly efficient peptide-HLA class I binding assay using unfolded heavy chain molecules: identification of HIV-1 derived peptides that bind to HLA-A*0201 and HLA-A*0301.
Journal of immunological methods 1997;205(2):201-9.
1997: LM Meadows; W Wang; Joke M M den Haan; Els Blokland; C Reinhardus; Jan Wouter Drijfhout; Jeffrey Shabanowitz; R Pierce; AI Agulnik; Jack alvarez; Donald F Hunt; Els Goulmy; Victor H Engelhard
The HLA-A*0201-restricted H-Y antigen contains a posttranslationally modified cysteine that significantly affects T cell recognition.
Immunity 1997;6(3):273-81.
1997: Tom H M Ottenhoff; Annemieke Geluk; Mireille Toebes; Willemien Benckhuijsen; Krista E van Meijgaarden; Jan Wouter Drijfhout
A sensitive fluorometric assay for quantitatively measuring specific peptide binding to HLA class I and class II molecules.
Journal of immunological methods 1997;200(1-2):89-97.
1997: Y van de Wal; Yvonne M C Kooy; Jan Wouter Drijfhout; R Amons; George K Papadopoulos; Frits Koning
Unique peptide binding characteristics of the disease-associated DQ(alpha 1*0501, beta 1*0201) vs the non-disease-associated DQ(alpha 1*0201, beta 1*0202) molecule.
Immunogenetics 1997;46(6):484-92.
1997: MC Tan; A Mieke Mommaas; Jan Wouter Drijfhout; R Jordens; Jos J M Onderwater; Desiree Verwoerd; Aat A Mulder; A N van der Heiden; Tom H M Ottenhoff; M Cella; A Tulp; Jacques Neefjes; Frits Koning
Mannose receptor mediated uptake of antigens strongly enhances HLA-class II restricted antigen presentation by cultured dendritic cells.
Advances in experimental medicine and biology 1997;417():171-4.
1996: B Beekman; Jan Wouter Drijfhout; W Bloemhoff; H Karel Ronday; P P Tak; Johan teKoppele
Convenient fluorometric assay for matrix metalloproteinase activity and its application in biological media.
FEBS letters 1996;390(2):221-5.
1996: F A Verreck; Corine Vermeulen; A V Poel; P Jorritsma; R Amons; J E Coligan; Jan Wouter Drijfhout; Frits Koning
The generation of SDS-stable HLA DR dimers is independent of efficient peptide binding.
International immunology 1996;8(3):397-404.
1996: Y van de Wal; Yvonne M C Kooy; Jan Wouter Drijfhout; R Amons; Frits Koning
Peptide binding characteristics of the coeliac disease-associated DQ(alpha1*0501, beta1*0201) molecule.
Immunogenetics 1996;44(4):246-53.
1996: F A Verreck; A van de Poel; Jan Wouter Drijfhout; R Amons; J E Coligan; F Konig
Natural peptides isolated from Gly86/Val86-containing variants of HLA-DR1, -DR11, -DR13, and -DR52.
Immunogenetics 1996;43(6):392-7.
1995: Sjoerd H van der burg; E Ras; Jan Wouter Drijfhout; Willemien Benckhuijsen; A J Bremers; Cornelis J M Melief; W Martin Kast
An HLA class I peptide-binding assay based on competition for binding to class I molecules on intact human B cells. Identification of conserved HIV-1 polymerase peptides binding to HLA-A*0301.
Human immunology 1995;44(4):189-98.
1995: H S de Koster; R Amons; Willemien Benckhuijsen; M Feijlbrief; G A Schellekens; Jan Wouter Drijfhout
The use of dedicated peptide libraries permits the discovery of high affinity binding peptides.
Journal of immunological methods 1995;187(1):179-88.
1995: Brigitte Wieles; J van Noort; Jan Wouter Drijfhout; R Offringa; A Holmgren; Tom H M Ottenhoff
Purification and functional analysis of the Mycobacterium leprae thioredoxin/thioredoxin reductase hybrid protein.
The Journal of biological chemistry 1995;270(43):25604-6.
1995: Annemieke Geluk; Krista E van Meijgaarden; Jan Wouter Drijfhout; Tom H M Ottenhoff
Clip binds to HLA class II using methionine-based, allele-dependent motifs as well as allele-independent supermotifs.
Molecular immunology 1995;32(13):975-81.
1995: Joke M M den Haan; N E Sherman; Els Blokland; E Huczko; Frits Koning; Jan Wouter Drijfhout; JC Skipper; Jeffrey Shabanowitz; Donald F Hunt; Victor H Engelhard
Identification of a graft versus host disease-associated human minor histocompatibility antigen.
Science (New York, N.Y.) 1995;268(5216):1476-80.
1995: Joe D'Amaro; J G Houbiers; Jan Wouter Drijfhout; RM Brandt; R Schipper; J N Bavinck; Cornelis J M Melief; W Martin Kast
A computer program for predicting possible cytotoxic T lymphocyte epitopes based on HLA class I peptide-binding motifs.
Human immunology 1995;43(1):13-8.
1995: Jan Wouter Drijfhout; RM Brandt; Joe D'Amaro; W Martin Kast; Cornelis J M Melief
Detailed motifs for peptide binding to HLA-A*0201 derived from large random sets of peptides using a cellular binding assay.
Human immunology 1995;43(1):1-12.
1994: G A Schellekens; E Lasonder; M Feijlbrief; D G Koedijk; Jan Wouter Drijfhout; A J Scheffer; Sytske Welling-Wester; Gjalt W Welling
Identification of the core residues of the epitope of a monoclonal antibody raised against glycoprotein D of herpes simplex virus type 1 by screening of a random peptide library.
European journal of immunology 1994;24(12):3188-93.
1994: Annemieke Geluk; Krista E van Meijgaarden; Scott Southwood; Carla Oseroff; Jan Wouter Drijfhout; René R P De Vries; Tom H M Ottenhoff; Alessandro Sette
HLA-DR3 molecules can bind peptides carrying two alternative specific submotifs.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(12):5742-8.
1994: W Martin Kast; RM Brandt; J Sidney; Jan Wouter Drijfhout; R T Kubo; Howard Grey; Cornelis J M Melief; Alessandro Sette
Role of HLA-A motifs in identification of potential CTL epitopes in human papillomavirus type 16 E6 and E7 proteins.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(8):3904-12.
1994: F A Verreck; A van de Poel; A Termijtelen; R Amons; Jan Wouter Drijfhout; Frits Koning
Identification of an HLA-DQ2 peptide binding motif and HLA-DPw3-bound self-peptide by pool sequencing.
European journal of immunology 1994;24(2):375-9.
1994: Sytske Welling-Wester; M Feijlbrief; D G Koedijk; Jan Wouter Drijfhout; W J Weijer; A J Scheffer; Gjalt W Welling
Analogues of peptide 9-21 of glycoprotein D of herpes simplex virus and their binding to group VII monoclonal antibodies.
Archives of virology 1994;138(3-4):331-40.
1994: E Filley; J E Thole; Graham Rook; S Nagai; M Waters; Jan Wouter Drijfhout; T F Rinke de Wit; René R P De Vries; C Abou-Zeid
Identification of an antigenic domain on Mycobacterium leprae protein antigen 85B, which is specifically recognized by antibodies from patients with leprosy.
The Journal of infectious diseases 1994;169(1):162-9.
1993: J G Houbiers; HW Nijman; Sjoerd H van der burg; Jan Wouter Drijfhout; Peter Kenemans; Cornelis J H van de Velde; Anneke Brand; F Momburg; W Martin Kast; Cornelis J M Melief
In vitro induction of human cytotoxic T lymphocyte responses against peptides of mutant and wild-type p53.
European journal of immunology 1993;23(9):2072-7.
1993: M C Feltkamp; H L Smits; Michel P M Vierboom; R P Minnaar; B M de Jongh; Jan Wouter Drijfhout; Jan ter Schegget; Cornelis J M Melief; W Martin Kast
Vaccination with cytotoxic T lymphocyte epitope-containing peptide protects against a tumor induced by human papillomavirus type 16-transformed cells.
European journal of immunology 1993;23(9):2242-9.
1993: W Martin Kast; RM Brandt; Jan Wouter Drijfhout; Cornelis J M Melief
Human leukocyte antigen-A2.1 restricted candidate cytotoxic T lymphocyte epitopes of human papillomavirus type 16 E6 and E7 proteins identified by using the processing-defective human cell line T2.
Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy 1993;14(2):115-20.
1993: HW Nijman; J G Houbiers; Michel P M Vierboom; Sjoerd H van der burg; Jan Wouter Drijfhout; Joe D'Amaro; Peter Kenemans; Cornelis J M Melief; W Martin Kast
Identification of peptide sequences that potentially trigger HLA-A2.1-restricted cytotoxic T lymphocytes.
European journal of immunology 1993;23(6):1215-9.
1993: M de Bueger; F Verreck; Els Blokland; Jan Wouter Drijfhout; R Amons; Frits Koning; Els Goulmy
Isolation of an HLA-A2.1 extracted human minor histocompatibility peptide.
European journal of immunology 1993;23(3):614-8.
1993: R A Damhof; Jan Wouter Drijfhout; A J Scheffer; J B Wilterdink; Gjalt W Welling; Sytske Welling-Wester
T cell responses to synthetic peptides of herpes simplex virus type 1 glycoprotein D in naturally infected individuals.
Archives of virology 1993;130(1-2):187-93.
1992: Annemieke Geluk; Krista E van Meijgaarden; Anneke A M Janson; Jan Wouter Drijfhout; R H Meloen; René R P De Vries; Tom H M Ottenhoff
Functional analysis of DR17(DR3)-restricted mycobacterial T cell epitopes reveals DR17-binding motif and enables the design of allele-specific competitor peptides.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(9):2864-71.
1992: T F Rinke de Wit; S Bekelie; A Osland; T L Miko; Peter W M Hermans; D van Soolingen; Jan Wouter Drijfhout; R Schöningh; Anneke A M Janson; J E Thole
Mycobacteria contain two groEL genes: the second Mycobacterium leprae groEL gene is arranged in an operon with groES.
Molecular microbiology 1992;6(14):1995-2007.
1991: Gjalt W Welling; J van Gorkum; R A Damhof; Jan Wouter Drijfhout; W Bloemhoff; Sytske Welling-Wester
A ten-residue fragment of an antibody (mini-antibody) directed against lysozyme as ligand in immunoaffinity chromatography.
Journal of chromatography 1991;548(1-2):235-42.
1991: Jan Wouter Drijfhout; W Bloemhoff
A new synthetic functionalized antigen carrier.
International journal of peptide and protein research 1991;37(1):27-32.
1990: H J Geerligs; C H Kocken; Jan Wouter Drijfhout; W J Weijer; W Bloemhoff; J B Wilterdink; Gjalt W Welling; Sytske Welling-Wester
Virus neutralizing activity induced by synthetic peptides of glycoprotein D of herpes simplex virus type 1, selected by their reactivity with hyperimmune sera from mice.
The Journal of general virology 1990;71 ( Pt 8)():1767-74.
1990: Gjalt W Welling; T Geurts; J van Gorkum; R A Damhof; Jan Wouter Drijfhout; W Bloemhoff; Sytske Welling-Wester
Synthetic antibody fragment as ligand in immunoaffinity chromatography.
Journal of chromatography 1990;512():337-43.
1990: Jan Wouter Drijfhout; W Bloemhoff; J T Poolman; P Hoogerhout
Solid-phase synthesis and applications of N-(S-acetylmercaptoacetyl) peptides.
Analytical biochemistry 1990;187(2):349-54.
1990: H J Geerligs; M Feijlbrief; M Bolk; C A Bos; Jan Wouter Drijfhout; Gjalt W Welling; Sytske Welling-Wester
Reactivity of human sera with overlapping synthetic peptides of herpes simplex virus type 1 glycoprotein D.
Archives of virology 1990;114(3-4):251-8.
1989: Jan van der Ploeg; Jan Wouter Drijfhout; M Feijlbrief; W Bloemhoff; Gjalt W Welling; Sytske Welling-Wester
Immunological properties of multiple repeats of a linear epitope of herpes simplex virus type 1 glycoprotein D.
Journal of immunological methods 1989;124(2):211-7.
1988: Jan Wouter Drijfhout; E W Perdijk; W J Weijer; W Bloemhoff
Controlled peptide-protein conjugation by means of 3-nitro-2-pyridinesulfenyl protection-activation.
International journal of peptide and protein research 1988;32(3):161-6.
1988: W J Weijer; Jan Wouter Drijfhout; H J Geerligs; W Bloemhoff; M Feijlbrief; C A Bos; P Hoogerhout; K E Kerling; T Popken-Boer; K Slopsema
Antibodies against synthetic peptides of herpes simplex virus type 1 glycoprotein D and their capability to neutralize viral infectivity in vitro.
Journal of virology 1988;62(2):501-10.
1988: C H Kocken; H J Geerligs; C A Bos; G Ab; W J Weijer; Jan Wouter Drijfhout; Gjalt W Welling; Sytske Welling-Wester
Immunological properties of an N-terminal fragment of herpes simplex virus type 1 glycoprotein D expressed in Escherichia coli.
Archives of virology 1988;103(3-4):267-74.