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Ralf Dringen

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Anatomy

Living Beings

Chemicals & Drugs

Disorders

Oxidative Stress

Physiology

Cell Survival

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Co-Publications
Name
33
Hamprecht, Bernd
17
Hirrlinger, Johannes
10
Robinson, Stephen
8
Gutterer, Jan Mirko
6
Kussmaul, L
6
Schulz, Jörg
6
Wiesinger, Heinrich
4
Liddell, Jeff
3
Leibfritz, Dieter
3
Kranich, O
3
Hoepken, Hans-Hermann
3
Bishop, Glenda
3
Crack, Peter
2
Gebhardt, Rolf
2
Giaume, Christian

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Publications

TOP 3
Dang Theresa N; Bishop Glenda M; Dringen Ralf; Robinson Stephen R
The putative heme transporter HCP1 is expressed in cultured astrocytes and contributes to the uptake of hemin.
Liddell Jeff R; Zwingmann Claudia; Schmidt Maike M; Thiessen Anette; Leibfritz Dieter; Robinson Stephen R; Dringen Ralf
Sustained hydrogen peroxide stress decreases lactate production by cultured astrocytes.
Schmidt Maike M; Dringen Ralf
Differential effects of iodoacetamide and iodoacetate on glycolysis and glutathione metabolism of cultured astrocytes.

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All Publications

2010: Dang Theresa N; Bishop Glenda M; Dringen Ralf; Robinson Stephen R
The putative heme transporter HCP1 is expressed in cultured astrocytes and contributes to the uptake of hemin.
Glia 2010;58(1):55-65.
2009: Liddell Jeff R; Zwingmann Claudia; Schmidt Maike M; Thiessen Anette; Leibfritz Dieter; Robinson Stephen R; Dringen Ralf
Sustained hydrogen peroxide stress decreases lactate production by cultured astrocytes.
Journal of neuroscience research 2009;87(12):2696-708.
2009: Schmidt Maike M; Dringen Ralf
Differential effects of iodoacetamide and iodoacetate on glycolysis and glutathione metabolism of cultured astrocytes.
Frontiers in neuroenergetics 2009;1():1.
2008: Frade João; Pope Simon; Schmidt Maike; Dringen Ralf; Barbosa Rui; Pocock Jennifer; Laranjinha João; Heales Simon
Glutamate induces release of glutathione from cultured rat astrocytes--a possible neuroprotective mechanism?
Journal of neurochemistry 2008;105(4):1144-52.
2008: Arning Jürgen; Dringen Ralf; Schmidt Maike; Thiessen Anette; Stolte Stefan; Matzke Marianne; Bottin-Weber Ulrike; Caesar-Geertz Birgit; Jastorff Bernd; Ranke Johannes
Structure-activity relationships for the impact of selected isothiazol-3-one biocides on glutathione metabolism and glutathione reductase of the human liver cell line Hep G2.
Toxicology 2008;246(2-3):203-12.
2007: Dringen Ralf; Bishop Glenda M; Koeppe Maico; Dang Theresa N; Robinson Stephen R
The pivotal role of astrocytes in the metabolism of iron in the brain.
Neurochemical research 2007;32(11):1884-90.
2007: Bishop Glenda M; Dringen Ralf; Robinson Stephen R
Zinc stimulates the production of toxic reactive oxygen species (ROS) and inhibits glutathione reductase in astrocytes.
Free radical biology & medicine 2007;42(8):1222-30.
2007: Rana Sanyukta; Dringen Ralf
Gap junction hemichannel-mediated release of glutathione from cultured rat astrocytes.
Neuroscience letters 2007;415(1):45-8.
2006: Waak Jens; Dringen Ralf
Formation and rapid export of the monochlorobimane-glutathione conjugate in cultured rat astrocytes.
Neurochemical research 2006;31(12):1409-16.
2006: Liddell Jeff R; Dringen Ralf; Crack Peter J; Robinson Stephen R
Glutathione peroxidase 1 and a high cellular glutathione concentration are essential for effective organic hydroperoxide detoxification in astrocytes.
Glia 2006;54(8):873-9.
2006: Knorpp T; Robinson S R; Crack P J; Dringen R
Glutathione peroxidase-1 contributes to the protection of glutamine synthetase in astrocytes during oxidative stress.
Journal of neural transmission (Vienna, Austria : 1996) 2006;113(9):1145-55.
2006: Liddell Jeff R; Hoepken Hans H; Crack Peter J; Robinson Stephen R; Dringen Ralf
Glutathione peroxidase 1 and glutathione are required to protect mouse astrocytes from iron-mediated hydrogen peroxide toxicity.
Journal of neuroscience research 2006;84(3):578-86.
2006: Minich Tobias; Riemer Jan; Schulz Jörg B; Wielinga Peter; Wijnholds Jan; Dringen Ralf
The multidrug resistance protein 1 (Mrp1), but not Mrp5, mediates export of glutathione and glutathione disulfide from brain astrocytes.
Journal of neurochemistry 2006;97(2):373-84.
2006: El-Tahir Heba M; Dietz Frank; Dringen Ralf; Schwabe Kerstin; Strenge Karen; Kelm Sørge; Abouzied Mekky M; Gieselmann Volkmar; Franken Sebastian
Expression of hepatoma-derived growth factor family members in the adult central nervous system.
BMC neuroscience 2006;7():6.
2005: Hirrlinger Johannes; Moeller Heinz; Kirchhoff Frank; Dringen Ralf
Expression of multidrug resistance proteins (Mrps) in astrocytes of the mouse brain: a single cell RT-PCR study.
Neurochemical research 2005;30(10):1237-44.
2005: Dringen Ralf
Oxidative and antioxidative potential of brain microglial cells.
Antioxidants & redox signaling 2005;7(9-10):1223-33.
2005: Lotharius Julie; Falsig Jeppe; van Beek Johan; Payne Sarah; Dringen Ralf; Brundin Patrik; Leist Marcel
Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed-lineage kinase pathway.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(27):6329-42.
2005: Biagiotti Enrica; Ferri Paola; Dringen Ralf; Del Grande Paolo; Ninfali Paolino
Glucose-6-phosphate dehydrogenase and NADPH-consuming enzymes in the rat olfactory bulb.
Journal of neuroscience research 2005;80(3):434-41.
2005: Dringen Ralf; Pawlowski Petra G; Hirrlinger Johannes
Peroxide detoxification by brain cells.
Journal of neuroscience research 2005;79(1-2):157-65.
2005: Hirrlinger Johannes; Dringen Ralf
Multidrug resistance protein 1-mediated export of glutathione and glutathione disulfide from brain astrocytes.
Methods in enzymology 2005;400():395-409.
2004: Wick Antje; Wick Wolfgang; Hirrlinger Johannes; Gerhardt Ellen; Dringen Ralf; Dichgans Johannes; Weller Michael; Schulz Jörg B
Chemotherapy-induced cell death in primary cerebellar granule neurons but not in astrocytes: in vitro paradigm of differential neurotoxicity.
Journal of neurochemistry 2004;91(5):1067-74.
2004: Riemer Jan; Hoepken Hans Hermann; Czerwinska Hania; Robinson Stephen R; Dringen Ralf
Colorimetric ferrozine-based assay for the quantitation of iron in cultured cells.
Analytical biochemistry 2004;331(2):370-5.
2004: Liddell Jeff R; Robinson Stephen R; Dringen Ralf
Endogenous glutathione and catalase protect cultured rat astrocytes from the iron-mediated toxicity of hydrogen peroxide.
Neuroscience letters 2004;364(3):164-7.
2004: Hoepken Hans H; Korten Till; Robinson Stephen R; Dringen Ralf
Iron accumulation, iron-mediated toxicity and altered levels of ferritin and transferrin receptor in cultured astrocytes during incubation with ferric ammonium citrate.
Journal of neurochemistry 2004;88(5):1194-202.
2004: Ruedig Cornelia; Dringen Ralf
TNF alpha increases activity of gamma-glutamyl transpeptidase in cultured rat astroglial cells.
Journal of neuroscience research 2004;75(4):536-43.
2003: Pawlowski P G; Dringen R
Identification of Nepsilon-(carboxymethyl)lysine-positive cells in astroglia-rich primary cultures.
Journal of neural transmission (Vienna, Austria : 1996) 2003;110(10):1077-90.
2003: Minich Tobias; Yokota Sadaki; Dringen Ralf
Cytosolic and mitochondrial isoforms of NADP+-dependent isocitrate dehydrogenases are expressed in cultured rat neurons, astrocytes, oligodendrocytes and microglial cells.
Journal of neurochemistry 2003;86(3):605-14.
2003: Hasselblatt Martin; Bunte Marion; Dringen Ralf; Tabernero Arantxa; Medina José M; Giaume Christian; Sirén Anna-Leena; Ehrenreich Hannelore
Effect of endothelin-1 on astrocytic protein content.
Glia 2003;42(4):390-7.
2003: Dringen Ralf; Hirrlinger Johannes
Glutathione pathways in the brain.
Biological chemistry 2003;384(4):505-16.
2002: Hirrlinger Johannes; König Jörg; Dringen Ralf
Expression of mRNAs of multidrug resistance proteins (Mrps) in cultured rat astrocytes, oligodendrocytes, microglial cells and neurones.
Journal of neurochemistry 2002;82(3):716-9.
2002: Hirrlinger Johannes; Resch Alexandra; Gutterer Jan Mirko; Dringen Ralf
Oligodendroglial cells in culture effectively dispose of exogenous hydrogen peroxide: comparison with cultured neurones, astroglial and microglial cells.
Journal of neurochemistry 2002;82(3):635-44.
2002: Hirrlinger Johannes; Schulz Jörg B; Dringen Ralf
Effects of dopamine on the glutathione metabolism of cultured astroglial cells: implications for Parkinson's disease.
Journal of neurochemistry 2002;82(3):458-67.
2002: Hirrlinger Johannes; Schulz Jörg B; Dringen Ralf
Glutathione release from cultured brain cells: multidrug resistance protein 1 mediates the release of GSH from rat astroglial cells.
Journal of neuroscience research 2002;69(3):318-26.
2002: Dringen Ralf; Gutterer Jan Mirko
Glutathione reductase from bovine brain.
Methods in enzymology 2002;348():281-8.
2001: Dringen R; Gutterer J M; Gros C; Hirrlinger J
Aminopeptidase N mediates the utilization of the GSH precursor CysGly by cultured neurons.
Journal of neuroscience research 2001;66(5):1003-8.
2001: Kirchhoff F; Dringen R; Giaume C
Pathways of neuron-astrocyte interactions and their possible role in neuroprotection.
European archives of psychiatry and clinical neuroscience 2001;251(4):159-69.
2001: Hirrlinger J; König J; Keppler D; Lindenau J; Schulz J B; Dringen R
The multidrug resistance protein MRP1 mediates the release of glutathione disulfide from rat astrocytes during oxidative stress.
Journal of neurochemistry 2001;76(2):627-36.
2001: Sokolova T; Gutterer J M; Hirrlinger J; Hamprecht B; Dringen R
Catalase in astroglia-rich primary cultures from rat brain: immunocytochemical localization and inactivation during the disposal of hydrogen peroxide.
Neuroscience letters 2001;297(2):129-32.
2000: Dringen R
Metabolism and functions of glutathione in brain.
Progress in neurobiology 2000;62(6):649-71.
2000: Hirrlinger J; Gutterer J M; Kussmaul L; Hamprecht B; Dringen R
Microglial cells in culture express a prominent glutathione system for the defense against reactive oxygen species.
Developmental neuroscience 2000;22(5-6):384-92.
2000: Rahman B; Kussmaul L; Hamprecht B; Dringen R
Glycogen is mobilized during the disposal of peroxides by cultured astroglial cells from rat brain.
Neuroscience letters 2000;290(3):169-72.
2000: Dringen R; Gutterer J M; Hirrlinger J
Glutathione metabolism in brain metabolic interaction between astrocytes and neurons in the defense against reactive oxygen species.
European journal of biochemistry / FEBS 2000;267(16):4912-6.
1999: Vogel R; Wiesinger H; Hamprecht B; Dringen R
The regeneration of reduced glutathione in rat forebrain mitochondria identifies metabolic pathways providing the NADPH required.
Neuroscience letters 1999;275(2):97-100.
1999: Gutterer J M; Dringen R; Hirrlinger J; Hamprecht B
Purification of glutathione reductase from bovine brain, generation of an antiserum, and immunocytochemical localization of the enzyme in neural cells.
Journal of neurochemistry 1999;73(4):1422-30.
1999: Kussmaul L; Hamprecht B; Dringen R
The detoxification of cumene hydroperoxide by the glutathione system of cultured astroglial cells hinges on hexose availability for the regeneration of NADPH.
Journal of neurochemistry 1999;73(3):1246-53.
1999: Hirrlinger J; Hamprecht B; Dringen R
Application and modulation of a permanent hydrogen peroxide-induced oxidative stress to cultured astroglial cells.
Brain research. Brain research protocols 1999;4(2):223-9.
1999: Dringen R; Kussmaul L; Gutterer J M; Hirrlinger J; Hamprecht B
The glutathione system of peroxide detoxification is less efficient in neurons than in astroglial cells.
Journal of neurochemistry 1999;72(6):2523-30.
1999: Dringen R; Hamprecht B
N-acetylcysteine, but not methionine or 2-oxothiazolidine-4-carboxylate, serves as cysteine donor for the synthesis of glutathione in cultured neurons derived from embryonal rat brain.
Neuroscience letters 1999;259(2):79-82.
1999: Dringen R; Pfeiffer B; Hamprecht B
Synthesis of the antioxidant glutathione in neurons: supply by astrocytes of CysGly as precursor for neuronal glutathione.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(2):562-9.
1998: Dringen R; Hamprecht B; Drukarch B
Anethole dithiolethione, a putative neuroprotectant, increases intracellular and extracellular glutathione levels during starvation of cultured astroglial cells.
Naunyn-Schmiedeberg's archives of pharmacology 1998;358(6):616-22.
1998: Brand A; Leibfritz D; Hamprecht B; Dringen R
Metabolism of cysteine in astroglial cells: synthesis of hypotaurine and taurine.
Journal of neurochemistry 1998;71(2):827-32.
1998: Dringen R; Hamprecht B; Bröer S
The peptide transporter PepT2 mediates the uptake of the glutathione precursor CysGly in astroglia-rich primary cultures.
Journal of neurochemistry 1998;71(1):388-93.
1998: Dringen R; Kussmaul L; Hamprecht B
Rapid clearance of tertiary butyl hydroperoxide by cultured astroglial cells via oxidation of glutathione.
Glia 1998;23(2):139-45.
1998: Dringen R; Kussmaul L; Hamprecht B
Detoxification of exogenous hydrogen peroxide and organic hydroperoxides by cultured astroglial cells assessed by microtiter plate assay.
Brain research. Brain research protocols 1998;2(3):223-8.
1998: Dringen R; Verleysdonk S; Hamprecht B; Willker W; Leibfritz D; Brand A
Metabolism of glycine in primary astroglial cells: synthesis of creatine, serine, and glutathione.
Journal of neurochemistry 1998;70(2):835-40.
1998: Kranich O; Dringen R; Sandberg M; Hamprecht B
Utilization of cysteine and cysteine precursors for the synthesis of glutathione in astroglial cultures: preference for cystine.
Glia 1998;22(1):11-8.
1998: Dringen R; Hamprecht B
Glutathione restoration as indicator for cellular metabolism of astroglial cells.
Developmental neuroscience 1998;20(4-5):401-7.
1997: Wiesinger H; Hamprecht B; Dringen R
Metabolic pathways for glucose in astrocytes.
Glia 1997;21(1):22-34.
1997: Dringen R; Kranich O; Löschmann P A; Hamprecht B
Use of dipeptides for the synthesis of glutathione by astroglia-rich primary cultures.
Journal of neurochemistry 1997;69(2):868-74.
1997: Dringen R; Hamprecht B
Involvement of glutathione peroxidase and catalase in the disposal of exogenous hydrogen peroxide by cultured astroglial cells.
Brain research 1997;759(1):67-75.
1997: Dringen R; Kranich O; Hamprecht B
The gamma-glutamyl transpeptidase inhibitor acivicin preserves glutathione released by astroglial cells in culture.
Neurochemical research 1997;22(6):727-33.
1996: Kranich O; Hamprecht B; Dringen R
Different preferences in the utilization of amino acids for glutathione synthesis in cultured neurons and astroglial cells derived from rat brain.
Neuroscience letters 1996;219(3):211-4.
1996: Dringen R; Hamprecht B
Glutathione content as an indicator for the presence of metabolic pathways of amino acids in astroglial cultures.
Journal of neurochemistry 1996;67(4):1375-82.
1996: Wüllner U; Löschmann P A; Schulz J B; Schmid A; Dringen R; Eblen F; Turski L; Klockgether T
Glutathione depletion potentiates MPTP and MPP+ toxicity in nigral dopaminergic neurones.
Neuroreport 1996;7(4):921-3.
1996: Bergbauer K; Dringen R; Verleysdonk S; Gebhardt R; Hamprecht B; Wiesinger H
Studies on fructose metabolism in cultured astroglial cells and control hepatocytes: lack of fructokinase activity and immunoreactivity in astrocytes.
Developmental neuroscience 1996;18(5-6):371-9.
1995: Dringen R; Peters H; Wiesinger H; Hamprecht B
Lactate transport in cultured glial cells.
Developmental neuroscience 1995;17(2):63-9.
1994: Dringen R; Bergbauer K; Wiesinger H; Hamprecht B
Utilization of mannose by astroglial cells.
Neurochemical research 1994;19(1):23-30.
1993: Dringen R; Wiesinger H; Hamprecht B
Uptake of L-lactate by cultured rat brain neurons.
Neuroscience letters 1993;163(1):5-7.
1993: Dringen R; Gebhardt R; Hamprecht B
Glycogen in astrocytes: possible function as lactate supply for neighboring cells.
Brain research 1993;623(2):208-14.
1993: Dringen R; Hamprecht B
Differences in glycogen metabolism in astroglia-rich primary cultures and sorbitol-selected astroglial cultures derived from mouse brain.
Glia 1993;8(3):143-9.
1993: Dringen R; Schmoll D; Cesar M; Hamprecht B
Incorporation of radioactivity from [14C]lactate into the glycogen of cultured mouse astroglial cells. Evidence for gluconeogenesis in brain cells.
Biological chemistry Hoppe-Seyler 1993;374(5):343-7.
1993: Dringen R; Hamprecht B
Inhibition by 2-deoxyglucose and 1,5-gluconolactone of glycogen mobilization in astroglia-rich primary cultures.
Journal of neurochemistry 1993;60(4):1498-504.
1992: Dringen R; Hamprecht B
Glucose, insulin, and insulin-like growth factor I regulate the glycogen content of astroglia-rich primary cultures.
Journal of neurochemistry 1992;58(2):511-7.

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