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James Driscoll

Research Profile

Chemicals & Drugs

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TOP 3
Michael J Munchhof; Amy S Antipas; Laura C Blumberg; William H Brissette; Matthew F Brown; Jeffrey M Casavant; Jonathan L Doty; James P Driscoll; Thomas M Harris; Lilli A Wolf-Gouveia; Christopher S Jones; Qifang Li; Robert G Linde; Paul D Lira; Anthony Marfat; Eric McElroy; Mark Mitton-Fry; Sandra P McCurdy; Lawrence A Reiter; Sharon L Ripp; Andrei Shavnya; Lisa M Thomasco; Kristen A Trevena
The identification of orally bioavailable thrombopoietin agonists.
Amit S Kalgutkar; James P Driscoll; Sabrina X Zhao; Gregory S Walker; Richard M Shepard; John R Soglia; James Atherton; Linning Yu; Abdul E Mutlib; Michael J Munchhof; Lawrence A Reiter; Christopher S Jones; Johnathan L Doty; Kristen A Trevena; Christopher L Shaffer; Sharon L Ripp
A rational chemical intervention strategy to circumvent bioactivation liabilities associated with a nonpeptidyl thrombopoietin receptor agonist containing a 2-amino-4-arylthiazole motif.
James P Driscoll; Katherine Kornecki; Joanna P Wolkowski; Lou Chupak; Amit S Kalgutkar; John P O'Donnell
Bioactivation of phencyclidine in rat and human liver microsomes and recombinant P450 2B enzymes: evidence for the formation of a novel quinone methide intermediate.

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2009: Michael J Munchhof; Amy S Antipas; Laura C Blumberg; William H Brissette; Matthew F Brown; Jeffrey M Casavant; Jonathan L Doty; James P Driscoll; Thomas M Harris; Lilli A Wolf-Gouveia; Christopher S Jones; Qifang Li; Robert G Linde; Paul D Lira; Anthony Marfat; Eric McElroy; Mark Mitton-Fry; Sandra P McCurdy; Lawrence A Reiter; Sharon L Ripp; Andrei Shavnya; Lisa M Thomasco; Kristen A Trevena
The identification of orally bioavailable thrombopoietin agonists.
Bioorganic & medicinal chemistry letters 2009;19(5):1428-30.
2007: Amit S Kalgutkar; James P Driscoll; Sabrina X Zhao; Gregory S Walker; Richard M Shepard; John R Soglia; James Atherton; Linning Yu; Abdul E Mutlib; Michael J Munchhof; Lawrence A Reiter; Christopher S Jones; Johnathan L Doty; Kristen A Trevena; Christopher L Shaffer; Sharon L Ripp
A rational chemical intervention strategy to circumvent bioactivation liabilities associated with a nonpeptidyl thrombopoietin receptor agonist containing a 2-amino-4-arylthiazole motif.
Chemical research in toxicology 2007;20(12):1954-65.
2007: James P Driscoll; Katherine Kornecki; Joanna P Wolkowski; Lou Chupak; Amit S Kalgutkar; John P O'Donnell
Bioactivation of phencyclidine in rat and human liver microsomes and recombinant P450 2B enzymes: evidence for the formation of a novel quinone methide intermediate.
Chemical research in toxicology 2007;20(10):1488-97.
2007: Lawrence A Reiter; Chakrapani Subramanyam; Emilio J Mangual; Christopher S Jones; Marc I Smeets; William H Brissette; Sandra P McCurdy; Paul D Lira; Robert G Linde; Qifang Li; Fangning Zhang; Amy S Antipas; Laura C Blumberg; Jonathan L Doty; James P Driscoll; Michael J Munchhof; Sharon L Ripp; Andrei Shavnya; Richard M Shepard; Diana Sperger; Lisa M Thomasco; Kristen A Trevena; Lilli A Wolf-Gouveia; Liling Zhang
Pyrimidine benzamide-based thrombopoietin receptor agonists.
Bioorganic & medicinal chemistry letters 2007;17(19):5447-54.
2007: Matthew F Brown; Kevin Bahnck; Laura C Blumberg; William H Brissette; Sara A Burrell; James P Driscoll; Flavia Fedeles; Michael B Fisher; Robert S Foti; Ronald P Gladue; Aikomari Guzman-Martinez; Matthew M Hayward; Paul D Lira; Brett M Lillie; Yi Lu; Greg D Lundquist; Eric B McElroy; Molly A McGlynn; Timothy J Paradis; Christopher S Poss; James H Roache; Andrei Shavnya; Richard M Shepard; Kristen A Trevena; Laurie A Tylaska
Piperazinyl CCR1 antagonists--optimization of human liver microsome stability.
Bioorganic & medicinal chemistry letters 2007;17(11):3109-12.