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Wulf Dröge

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Eggert Holm; Wulf Hildebrandt; Ralf Kinscherf; Wulf Dröge
Low postabsorptive net protein degradation in male cancer patients: lack of sensitivity to regulatory amino acids?
Gabriel A Bonaterra; Wulf Hildebrandt; Anne Bodens; Roland Sauer; Klaus A Dugi; Hans-Peter Deigner; Dan Turcanu; Helmut Heinle; Wulf Dröge; Jürgen Metz; Ralf Kinscherf
Increased gene expression of scavenger receptors and proinflammatory markers in peripheral blood mononuclear cells of hyperlipidemic males.
Bernd Sido; Cornelia Seel; Achim Hochlehnert; Raoul Breitkreutz; Wulf Dröge
Low intestinal glutamine level and low glutaminase activity in Crohn's disease: a rational for glutamine supplementation?

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2007: Eggert Holm; Wulf Hildebrandt; Ralf Kinscherf; Wulf Dröge
Low postabsorptive net protein degradation in male cancer patients: lack of sensitivity to regulatory amino acids?
Oncology reports 2007;17(3):695-700.
2007: Gabriel A Bonaterra; Wulf Hildebrandt; Anne Bodens; Roland Sauer; Klaus A Dugi; Hans-Peter Deigner; Dan Turcanu; Helmut Heinle; Wulf Dröge; Jürgen Metz; Ralf Kinscherf
Increased gene expression of scavenger receptors and proinflammatory markers in peripheral blood mononuclear cells of hyperlipidemic males.
Journal of molecular medicine (Berlin, Germany) 2007;85(2):181-90.
2006: Bernd Sido; Cornelia Seel; Achim Hochlehnert; Raoul Breitkreutz; Wulf Dröge
Low intestinal glutamine level and low glutaminase activity in Crohn's disease: a rational for glutamine supplementation?
Digestive diseases and sciences 2006;51(12):2170-9.
2006: Wulf Dröge; Ralf Kinscherf; Wulf Hildebrandt; Thomas Schmitt
The deficit in low molecular weight thiols as a target for antiageing therapy.
Current drug targets 2006;7(11):1505-12.
2006: Thomas L Schmitt; Helmut Klein; Wulf Dröge
Hydrogen peroxide inhibits activity of the IGF-1 receptor kinase.
Redox report : communications in free radical research 2006;11(3):105-9.
2005: Wulf Dröge
Oxidative stress and ageing: is ageing a cysteine deficiency syndrome?
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2005;360(1464):2355-72.
2005: Wulf Dröge
Oxidative enhancement of insulin receptor signaling: experimental findings and clinical implications.
Antioxidants & redox signaling 2005;7(7-8):1071-7.
2005: Thomas L Schmitt; Agnes Hotz-Wagenblatt; Helmut Klein; Wulf Dröge
Interdependent regulation of insulin receptor kinase activity by ADP and hydrogen peroxide.
The Journal of biological chemistry 2005;280(5):3795-801.
2005: Gabriel A Bonaterra; Wulf Hildebrandt; Anne Bodens; Roland Sauer; Klaus A Dugi; Hans-Peter Deigner; Wulf Dröge; Jürgen Metz; Ralf Kinscherf
Increased cyclooxygenase-2 expression in peripheral blood mononuclear cells of smokers and hyperlipidemic subjects.
Free radical biology & medicine 2005;38(2):235-42.
2004: Wulf Hildebrandt; Andreas Hamann; Holger Krakowski-Roosen; Ralf Kinscherf; Klaus A Dugi; Roland Sauer; Sabrina Lacher; Nuria Nöbel; Anne Bodens; Vassiliki Bellou; Lutz Edler; Peter Nawroth; Wulf Dröge
Effect of thiol antioxidant on body fat and insulin reactivity.
Journal of molecular medicine (Berlin, Germany) 2004;82(5):336-44.
2004: Wulf Dröge
Autophagy and aging--importance of amino acid levels.
Mechanisms of ageing and development 2004;125(3):161-8.
2003: Andreas Möller; Hüseyin Sirma; Thomas G Hofmann; Hannah Staege; Ekaterina Gresko; Katharina Schmid Lüdi; Elisabeth Klimczak; Wulf Dröge; Hans Will; M Lienhard Schmitz
Sp100 is important for the stimulatory effect of homeodomain-interacting protein kinase-2 on p53-dependent gene expression.
Oncogene 2003;22(54):8731-7.
2003: Ralf Kinscherf; Konstantinos Cafaltzis; Falk Röder; Wulf Hildebrandt; Lutz Edler; Hans-Peter Deigner; Raoul Breitkreutz; Giso Feussner; Jörg Kreuzer; Egon Werle; Gerd Michel; Jürgen Metz; Wulf Dröge
Cholesterol levels linked to abnormal plasma thiol concentrations and thiol/disulfide redox status in hyperlipidemic subjects.
Free radical biology & medicine 2003;35(10):1286-92.
2003: Andreas Möller; Hüseyin Sirma; Thomas G Hofmann; Sven Rueffer; Elisabeth Klimczak; Wulf Dröge; Hans Will; M Lienhard Schmitz
PML is required for homeodomain-interacting protein kinase 2 (HIPK2)-mediated p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains.
Cancer research 2003;63(15):4310-4.
2003: Klaus Hauer; Wulf Hildebrandt; Yvonne Sehl; Lutz Edler; Peter Oster; Wulf Dröge
Improvement in muscular performance and decrease in tumor necrosis factor level in old age after antioxidant treatment.
Journal of molecular medicine (Berlin, Germany) 2003;81(2):118-25.
2003: Wulf Hildebrandt; Wulf Dröge
Thiol-mediated redox regulation.
Forum of nutrition 2003;56():199-200.
2003: Wulf Dröge
Oxidative stress and aging.
Advances in experimental medicine and biology 2003;543():191-200.
2003: Oliver Dienz; Andreas Möller; Andreas Strecker; Nadja Stephan; Peter H Krammer; Wulf Dröge; M Lienhard Schmitz
Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa and phospholipase C gamma 1 are required for NF-kappa B activation and lipid raft recruitment of protein kinase C theta induced by T cell costimulation.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(1):365-72.
2002: Wulf Dröge
Aging-related changes in the thiol/disulfide redox state: implications for the use of thiol antioxidants.
Experimental gerontology 2002;37(12):1333-45.
2002: Wulf Hildebrandt; Ralf Kinscherf; Klaus Hauer; Eggert Holm; Wulf Dröge
Plasma cystine concentration and redox state in aging and physical exercise.
Mechanisms of ageing and development 2002;123(9):1269-81.
2002: Wulf Dröge
The plasma redox state and ageing.
Ageing research reviews 2002;1(2):257-78.
2002: Wulf Hildebrandt; Steve Alexander; Peter Bärtsch; Wulf Dröge
Effect of N-acetyl-cysteine on the hypoxic ventilatory response and erythropoietin production: linkage between plasma thiol redox state and O(2) chemosensitivity.
Blood 2002;99(5):1552-5.
2002: M Lienhard Schmitz; Susanne Bacher; Wulf Dröge
Molecular analysis of mitogen-activated protein kinase signaling pathways induced by reactive oxygen intermediates.
Methods in enzymology 2002;352():53-61.
2002: Agnes Hotz-Wagenblatt; Wulf Dröge
Redox-mediated functional and structural changes in insulin receptor kinase.
Methods in enzymology 2002;348():288-96.
2002: Wulf Dröge
Free radicals in the physiological control of cell function.
Physiological reviews 2002;82(1):47-95.
2002: Thomas G Hofmann; Andreas Möller; Hüseyin Sirma; Hanswalter Zentgraf; Yoichi Taya; Wulf Dröge; Hans Will; M Lienhard Schmitz
Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2.
Nature cell biology 2002;4(1):1-10.
2001: Raoul Breitkreutz; J Wagner; Mehmet Tokus; Axel Benner; Siegbert Rossol; N Pittack; J Stein; Wulf Dröge; Eggert Holm
Flux of amino acids and energy substrates across the leg in weight-stable HIV-infected patients with acute opportunistic infections: indication of a slow protein wasting process.
Journal of molecular medicine (Berlin, Germany) 2001;79(11):671-8.
2001: FJ Taut; Raoul Breitkreutz; Christina Zapletal; JC Thies; A Babylon; Eike Martin; Wulf Dröge
Influence of N-acetylcysteine on hepatic amino acid metabolism in patients undergoing orthotopic liver transplantation.
Transplant international : official journal of the European Society for Organ Transplantation 2001;14(5):329-33.
2001: Thomas G Hofmann; Andreas Möller; Steffen P Hehner; D Welsch; Wulf Dröge; M Lienhard Schmitz
CD95-induced JNK activation signals are transmitted by the death-inducing signaling complex (DISC), but not by Daxx.
International journal of cancer. Journal international du cancer 2001;93(2):185-91.
2001: Andreas Möller; Oliver Dienz; Steffen P Hehner; Wulf Dröge; M Lienhard Schmitz
Protein kinase C theta cooperates with Vav1 to induce JNK activity in T-cells.
The Journal of biological chemistry 2001;276(23):20022-8.
2001: Susanne Bacher; J Grosshans; Wulf Dröge; M Lienhard Schmitz
The Drosophila proteins Pelle and Tube induce JNK/AP-1 activity in mammalian cells.
FEBS letters 2001;497(2-3):153-8.
2000: Thomas G Hofmann; Antoaneta Mincheva; Peter Lichter; Wulf Dröge; M L Schmitz
Human homeodomain-interacting protein kinase-2 (HIPK2) is a member of the DYRK family of protein kinases and maps to chromosome 7q32-q34.
Biochimie 2000;82(12):1123-7.
2000: Wulf Dröge; Raoul Breitkreutz
Glutathione and immune function.
The Proceedings of the Nutrition Society 2000;59(4):595-600.
2000: Steffen P Hehner; Raoul Breitkreutz; G Shubinsky; H Unsoeld; Klaus Schulze-Osthoff; M Lienhard Schmitz; Wulf Dröge
Enhancement of T cell receptor signaling by a mild oxidative shift in the intracellular thiol pool.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(8):4319-28.
2000: Viktor Umansky; M Rocha; Raoul Breitkreutz; Steffen P Hehner; Mariana Bucur; N Erbe; Wulf Dröge; A Ushmorov
Glutathione is a factor of resistance of Jurkat leukemia cells to nitric oxide-mediated apoptosis.
Journal of cellular biochemistry 2000;78(4):578-87.
2000: barbara kaltschmidt; Christian Kaltschmidt; Thomas G Hofmann; Steffen P Hehner; Wulf Dröge; M Lienhard Schmitz
The pro- or anti-apoptotic function of NF-kappaB is determined by the nature of the apoptotic stimulus.
European journal of biochemistry / FEBS 2000;267(12):3828-35.
2000: Steffen P Hehner; Min Li-Weber; Marco Giaisi; Wulf Dröge; Peter H Krammer; M Lienhard Schmitz
Vav synergizes with protein kinase C theta to mediate IL-4 gene expression in response to CD28 costimulation in T cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(7):3829-36.
2000: Steffen P Hehner; Thomas G Hofmann; A Ushmorov; Oliver Dienz; I Wing-Lan Leung; N Lassam; C Scheidereit; Wulf Dröge; M Lienhard Schmitz
Mixed-lineage kinase 3 delivers CD3/CD28-derived signals into the IkappaB kinase complex.
Molecular and cellular biology 2000;20(7):2556-68.
2000: Thomas G Hofmann; Steffen P Hehner; Wulf Dröge; M Lienhard Schmitz
Caspase-dependent cleavage and inactivation of the Vav1 proto-oncogene product during apoptosis prevents IL-2 transcription.
Oncogene 2000;19(9):1153-63.
2000: Raoul Breitkreutz; S Holm; N Pittack; Matthias Beichert; A Babylon; J Yodoi; Wulf Dröge
Massive loss of sulfur in HIV infection.
AIDS research and human retroviruses 2000;16(3):203-9.
2000: Raoul Breitkreutz; N Pittack; C T Nebe; Dieter Schuster; Jürgen Brust; Matthias Beichert; Volker Hack; V Daniel; Lutz Edler; Wulf Dröge
Improvement of immune functions in HIV infection by sulfur supplementation: two randomized trials.
Journal of molecular medicine (Berlin, Germany) 2000;78(1):55-62.
2000: Raoul Breitkreutz; A Babylon; Volker Hack; K Schuster; Mehmet Tokus; H Böhles; E Hagmüller; Lutz Edler; Eggert Holm; Wulf Dröge
Effect of carnitine on muscular glutamate uptake and intramuscular glutathione in malignant diseases.
British journal of cancer 2000;82(2):399-403.
1999: Steffen P Hehner; Thomas G Hofmann; Wulf Dröge; M Lienhard Schmitz
The antiinflammatory sesquiterpene lactone parthenolide inhibits NF-kappa B by targeting the I kappa B kinase complex.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(10):5617-23.
1999: Wulf Dröge; Raoul Breitkreutz
N-acetyl-cysteine in the therapy of HIV-positive patients.
Current opinion in clinical nutrition and metabolic care 1999;2(6):493-8.
1999: Steffen P Hehner; Thomas G Hofmann; Wulf Dröge; M Lienhard Schmitz
Inhibition of tyrosine phosphatases induces apoptosis independent from the CD95 system.
Cell death and differentiation 1999;6(9):833-41.
1999: E Schmid; Agnes Hotz-Wagenblatt; V Hacj; Wulf Dröge
Phosphorylation of the insulin receptor kinase by phosphocreatine in combination with hydrogen peroxide: the structural basis of redox priming.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(12):1491-500.
1999: Steffen P Hehner; Thomas G Hofmann; F Ratter; Wulf Dröge; M Lienhard Schmitz
Inhibition of tyrosine phosphatases antagonizes CD95-mediated apoptosis.
European journal of biochemistry / FEBS 1999;264(1):132-9.
1999: A Ushmorov; Volker Hack; Wulf Dröge
Differential reconstitution of mitochondrial respiratory chain activity and plasma redox state by cysteine and ornithine in a model of cancer cachexia.
Cancer research 1999;59(14):3527-34.
1999: barbara kaltschmidt; Christian Kaltschmidt; Steffen P Hehner; Wulf Dröge; M Lienhard Schmitz
Repression of NF-kappaB impairs HeLa cell proliferation by functional interference with cell cycle checkpoint regulators.
Oncogene 1999;18(21):3213-25.
1999: Wulf Dröge
Cysteine and glutathione in catabolic conditions and immunological dysfunction.
Current opinion in clinical nutrition and metabolic care 1999;2(3):227-33.
1999: A Ushmorov; F Ratter; Volker Lehmann; Wulf Dröge; Volker Schirrmacher; Viktor Umansky
Nitric-oxide-induced apoptosis in human leukemic lines requires mitochondrial lipid degradation and cytochrome C release.
Blood 1999;93(7):2342-52.
1999: FJ Taut; Christina Zapletal; Ernst Klar; Johann Motsch; JC Thies; A Babylon; Eike Martin; Wulf Dröge; Raoul Breitkreutz
Sulfur-containing metabolites of N-acetylcysteine in patients undergoing orthotopic liver transplantation.
Transplantation proceedings 1999;31(1-2):411-3.
1999: A Dumont; Steffen P Hehner; Thomas G Hofmann; M Ueffing; Wulf Dröge; M Lienhard Schmitz
Hydrogen peroxide-induced apoptosis is CD95-independent, requires the release of mitochondria-derived reactive oxygen species and the activation of NF-kappaB.
Oncogene 1999;18(3):747-57.
1999: E Schmid; Agnes Hotz-Wagenblatt; Wulf Dröge
Inhibition of the insulin receptor kinase phosphorylation by nitric oxide: functional and structural aspects.
Antioxidants & redox signaling 1999;1(1):45-53.
1998: Thomas G Hofmann; Steffen P Hehner; Susanne Bacher; Wulf Dröge; M Lienhard Schmitz
Various glucocorticoids differ in their ability to induce gene expression, apoptosis and to repress NF-kappaB-dependent transcription.
FEBS letters 1998;441(3):441-6.
1998: V Umansky; Steffen P Hehner; A Dumont; Thomas G Hofmann; V Schirrmacher; Wulf Dröge; M Lienhard Schmitz
Co-stimulatory effect of nitric oxide on endothelial NF-kappaB implies a physiological self-amplifying mechanism.
European journal of immunology 1998;28(8):2276-82.
1998: Steffen P Hehner; Thomas G Hofmann; F Ratter; A Dumont; Wulf Dröge; M Lienhard Schmitz
Tumor necrosis factor-alpha-induced cell killing and activation of transcription factor NF-kappaB are uncoupled in L929 cells.
The Journal of biological chemistry 1998;273(29):18117-21.
1998: E Schmid; J El Benna; D Galter; G Klein; Wulf Dröge
Redox priming of the insulin receptor beta-chain associated with altered tyrosine kinase activity and insulin responsiveness in the absence of tyrosine autophosphorylation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998;12(10):863-70.
1998: Volker Hack; Raoul Breitkreutz; Ralf Kinscherf; H Röhrer; Peter Bärtsch; FJ Taut; Axel Benner; Wulf Dröge
The redox state as a correlate of senescence and wasting and as a target for therapeutic intervention.
Blood 1998;92(1):59-67.
1998: Bernd Sido; Volker Hack; Achim Hochlehnert; H Lipps; Christian Herfarth; Wulf Dröge
Impairment of intestinal glutathione synthesis in patients with inflammatory bowel disease.
Gut 1998;42(4):485-92.
1998: Steffen P Hehner; M Heinrich; P M Bork; M Vogt; F Ratter; Volker Lehmann; Klaus Schulze-Osthoff; Wulf Dröge; M Lienhard Schmitz
Sesquiterpene lactones specifically inhibit activation of NF-kappa B by preventing the degradation of I kappa B-alpha and I kappa B-beta.
The Journal of biological chemistry 1998;273(3):1288-97.
1998: Wulf Dröge; Volker Hack; Raoul Breitkreutz; Eggert Holm; G Shubinsky; E Schmid; D Galter
Role of cysteine and glutathione in signal transduction, immunopathology and cachexia.
BioFactors (Oxford, England) 1998;8(1-2):97-102.
1997: Wulf Dröge; Eggert Holm
Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1997;11(13):1077-89.
1997: Volker Hack; A Gross; A Böhme; C Stahl-Hennig; Wulf Dröge
Decrease in phosphocreatine level in skeletal muscle of SIV-infected rhesus macaques correlates with decrease in intracellular glutathione.
AIDS research and human retroviruses 1997;13(13):1089-91.
1997: Eggert Holm; Volker Hack; Mehmet Tokus; Raoul Breitkreutz; A Babylon; Wulf Dröge
Linkage between postabsorptive amino acid release and glutamate uptake in skeletal muscle tissue of healthy young subjects, cancer patients, and the elderly.
Journal of molecular medicine (Berlin, Germany) 1997;75(6):454-61.
1997: Volker Hack; Claus Weiss; Birgit Friedmann; S Suttner; M Schykowski; N Erbe; Axel Benner; Peter Bärtsch; Wulf Dröge
Decreased plasma glutamine level and CD4+ T cell number in response to 8 wk of anaerobic training.
The American journal of physiology 1997;272(5 Pt 1):E788-95.
1997: Volker Hack; D Schmid; Raoul Breitkreutz; C Stahl-Henning; P Drings; Ralf Kinscherf; FJ Taut; Eggert Holm; Wulf Dröge
Cystine levels, cystine flux, and protein catabolism in cancer cachexia, HIV/SIV infection, and senescence.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1997;11(1):84-92.
1997: Wulf Dröge; A Gross; Volker Hack; Ralf Kinscherf; M Schykowski; M Bockstette; S Mihm; D Galter
Role of cysteine and glutathione in HIV infection and cancer cachexia: therapeutic intervention with N-acetylcysteine.
Advances in pharmacology (San Diego, Calif.) 1997;38():581-600.
1996: A Gross; Volker Hack; Christiane Stahl-Hennig; Wulf Dröge
Elevated hepatic gamma-glutamylcysteine synthetase activity and abnormal sulfate levels in liver and muscle tissue may explain abnormal cysteine and glutathione levels in SIV-infected rhesus macaques.
AIDS research and human retroviruses 1996;12(17):1639-41.
1996: Vladimir Shatrov; F Ratter; A Gruber; Wulf Dröge; Volker Lehmann
HIV type 1 glycoprotein 120 amplifies tumor necrosis factor-induced NF-kappa B activation in Jurkat cells.
AIDS research and human retroviruses 1996;12(13):1209-16.
1996: Volker Hack; A Gross; Ralf Kinscherf; M Bockstette; Walter Fiers; G Berke; Wulf Dröge
Abnormal glutathione and sulfate levels after interleukin 6 treatment and in tumor-induced cachexia.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(10):1219-26.
1996: Ralf Kinscherf; Volker Hack; T Fischbach; Birgit Friedmann; Claus Weiss; L Edler; Peter Bärtsch; Wulf Dröge
Low plasma glutamine in combination with high glutamate levels indicate risk for loss of body cell mass in healthy individuals: the effect of N-acetyl-cysteine.
Journal of molecular medicine (Berlin, Germany) 1996;74(7):393-400.
1996: F Ratter; Matthias Germer; T Fischbach; Klaus Schulze-Osthoff; Marcus E Peter; Wulf Dröge; Peter H Krammer; Volker Lehmann
S-adenosylhomocysteine as a physiological modulator of Apo-1-mediated apoptosis.
International immunology 1996;8(7):1139-47.
1996: Volker Hack; O Stütz; Ralf Kinscherf; M Schykowski; M Kellerer; Eggert Holm; Wulf Dröge
Elevated venous glutamate levels in (pre)catabolic conditions result at least partly from a decreased glutamate transport activity.
Journal of molecular medicine (Berlin, Germany) 1996;74(6):337-43.
1996: H Schenk; M Vogt; Wulf Dröge; Klaus Schulze-Osthoff
Thioredoxin as a potent costimulus of cytokine expression.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(2):765-71.
1995: Marek Los; H Schenk; K Hexel; PA Baeuerle; Wulf Dröge; Klaus Schulze-Osthoff
IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase.
The EMBO journal 1995;14(15):3731-40.
1995: Marek Los; M Van de Craen; Louis C Penning; H Schenk; M Westendorp; PA Baeuerle; Wulf Dröge; Peter H Krammer; Walter Fiers; Klaus Schulze-Osthoff
Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis.
Nature 1995;375(6526):81-3.
1995: M O Westendorp; Vladimir Shatrov; Klaus Schulze-Osthoff; R Frank; M Kraft; Marek Los; Peter H Krammer; Wulf Dröge; Volker Lehmann
HIV-1 Tat potentiates TNF-induced NF-kappa B activation and cytotoxicity by altering the cellular redox state.
The EMBO journal 1995;14(3):546-54.
1995: S Mihm; D Galter; Wulf Dröge
Modulation of transcription factor NF kappa B activity by intracellular glutathione levels and by variations of the extracellular cysteine supply.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1995;9(2):246-52.
1995: Claus Weiss; Ralf Kinscherf; S Roth; Birgit Friedmann; T Fischbach; J Reus; Wulf Dröge; Peter Bärtsch
Lymphocyte subpopulations and concentrations of soluble CD8 and CD4 antigen after anaerobic training.
International journal of sports medicine 1995;16(2):117-21.
1995: Marek Los; Wulf Dröge; K Stricker; PA Baeuerle; Klaus Schulze-Osthoff
Hydrogen peroxide as a potent activator of T lymphocyte functions.
European journal of immunology 1995;25(1):159-65.
1995: Wulf Dröge; Ralf Kinscherf; S Mihm; D Galter; S Roth; H Gmünder; T Fischbach; M Bockstette
Thiols and the immune system: effect of N-acetylcysteine on T cell system in human subjects.
Methods in enzymology 1995;251():255-70.
1995: Klaus Schulze-Osthoff; H Schenk; Wulf Dröge
Effects of thioredoxin on activation of transcription factor NF-kappa B.
Methods in enzymology 1995;252():253-64.
1994: Wulf Dröge; Klaus Schulze-Osthoff; S Mihm; D Galter; H Schenk; H P Eck; S Roth; H Gmünder
Functions of glutathione and glutathione disulfide in immunology and immunopathology.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1994;8(14):1131-8.
1994: Klaus Schulze-Osthoff; Peter H Krammer; Wulf Dröge
Divergent signalling via APO-1/Fas and the TNF receptor, two homologous molecules involved in physiological cell death.
The EMBO journal 1994;13(19):4587-96.
1994: Klaus Schulze-Osthoff; Henning Walczak; Wulf Dröge; Peter H Krammer
Cell nucleus and DNA fragmentation are not required for apoptosis.
The Journal of cell biology 1994;127(1):15-20.
1994: Marek Los; Wulf Dröge; Klaus Schulze-Osthoff
Inhibition of activation of transcription factor AP-1 by CD28 signalling in human T-cells.
The Biochemical journal 1994;302 ( Pt 1)():119-23.
1994: D Galter; S Mihm; Wulf Dröge
Distinct effects of glutathione disulphide on the nuclear transcription factor kappa B and the activator protein-1.
European journal of biochemistry / FEBS 1994;221(2):639-48.
1994: S Roth; Wulf Dröge
Glutathione reverses the inhibition of T cell responses by superoptimal numbers of "nonprofessional" antigen presenting cells.
Cellular immunology 1994;155(1):183-94.
1994: Ralf Kinscherf; T Fischbach; S Mihm; S Roth; E Hohenhaus-Sievert; Claus Weiss; L Edler; Peter Bärtsch; Wulf Dröge
Effect of glutathione depletion and oral N-acetyl-cysteine treatment on CD4+ and CD8+ cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1994;8(6):448-51.
1994: H Schenk; M Klein; Wilhelm Erdbrügger; Wulf Dröge; Klaus Schulze-Osthoff
Distinct effects of thioredoxin and antioxidants on the activation of transcription factors NF-kappa B and AP-1.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(5):1672-6.
1994: Wulf Dröge; H P Eck; S Mihm; S Roth; Ralf Kinscherf; T Fischbach
The role of a cysteine and glutathione deficiency in the immunopathology of HIV infection.
Acta microbiologica et immunologica Hungarica 1994;41 Suppl():17-20.
1994: Wulf Dröge; H P Eck; S Mihm
Oxidant-antioxidant status in human immunodeficiency virus infection.
Methods in enzymology 1994;233():594-601.
1994: Wulf Dröge; S Mihm; M Bockstette; S Roth
Effect of reactive oxygen intermediates and antioxidants on proliferation and function of T lymphocytes.
Methods in enzymology 1994;234():135-51.
1993: Wulf Dröge; Krishna K Murthy; Christiane Stahl-Hennig; S Hartung; Roland Plesker; S Rouse; E Peterhans; Ralf Kinscherf; T Fischbach; H P Eck
Plasma amino acid dysregulation after lentiviral infection.
AIDS research and human retroviruses 1993;9(9):807-9.
1992: Wulf Dröge; H P Eck; S Mihm
HIV-induced cysteine deficiency and T-cell dysfunction--a rationale for treatment with N-acetylcysteine.
Immunology today 1992;13(6):211-4.
1992: J S Lim; H P Eck; H Gmünder; Wulf Dröge
Expression of increased immunogenicity by thiol-releasing tumor variants.
Cellular immunology 1992;140(2):345-56.
1991: Wulf Dröge; H P Eck; H Gmünder; S Mihm
Requirement for prooxidant and antioxidant states in T cell mediated immune responses.--Relevance for the pathogenetic mechanisms of AIDS?
Klinische Wochenschrift 1991;69(21-23):1118-22.
1991: H Gmünder; Wulf Dröge
Differential effects of glutathione depletion on T cell subsets.
Cellular immunology 1991;138(1):229-37.
1991: H Gmünder; H P Eck; Wulf Dröge
Low membrane transport activity for cystine in resting and mitogenically stimulated human lymphocyte preparations and human T cell clones.
European journal of biochemistry / FEBS 1991;201(1):113-7.
1991: Wulf Dröge; H P Eck; H Gmünder; S Mihm
Modulation of lymphocyte functions and immune responses by cysteine and cysteine derivatives.
The American journal of medicine 1991;91(3C):140S-144S.
1991: H P Eck; Christiane Stahl-Hennig; G Hunsmann; Wulf Dröge
Metabolic disorder as early consequence of simian immunodeficiency virus infection in rhesus macaques.
Lancet 1991;338(8763):346-7.
1991: S Roth; H Gmünder; Wulf Dröge
Regulation of intracellular glutathione levels and lymphocyte functions by lactate.
Cellular immunology 1991;136(1):95-104.
1991: Volker Lehmann; B Benninghoff; Wulf Dröge
Selective induction of metabolic activation programs in peritoneal macrophages by lipopolysaccharide substructures.
Infection and immunity 1991;59(8):2822-7.
1991: S Roth; Wulf Dröge
Regulation of interleukin 2 production, interleukin 2 mRNA expression and intracellular glutathione levels in ex vivo derived T lymphocytes by lactate.
European journal of immunology 1991;21(8):1933-7.
1991: B Benninghoff; Volker Lehmann; H P Eck; Wulf Dröge
Production of citrulline and ornithine by interferon-gamma treated macrophages.
International immunology 1991;3(5):413-7.
1991: S Mihm; J Ennen; U Pessara; R Kurth; Wulf Dröge
Inhibition of HIV-1 replication and NF-kappa B activity by cysteine and cysteine derivatives.
AIDS (London, England) 1991;5(5):497-503.
1991: Wulf Dröge; M Wolf; B Häcker-Shahin; H Kriegbaum; B Benninghoff; H Gmünder; H P Eck; S Mihm
Immunomodulatory action of eicosanoids and other small molecular weight products of macrophages.
Annali dell'Istituto superiore di sanità 1991;27(1):67-9.
1990: H Gmünder; S Roth; H P Eck; H Gallas; S Mihm; Wulf Dröge
Interleukin-2 mRNA expression, lymphokine production and DNA synthesis in glutathione-depleted T cells.
Cellular immunology 1990;130(2):520-8.
1990: H Gmünder; H P Eck; B Benninghoff; S Roth; Wulf Dröge
Macrophages regulate intracellular glutathione levels of lymphocytes. Evidence for an immunoregulatory role of cysteine.
Cellular immunology 1990;129(1):32-46.
1990: H P Eck; M Betzler; P Schlag; Wulf Dröge
Partial recovery of lymphocyte activity in patients with colorectal carcinoma after curative surgical treatment and return of plasma glutamate concentrations to normal levels.
Journal of cancer research and clinical oncology 1990;116(6):648-50.
1989: B Benninghoff; Wulf Dröge; Volker Lehmann
The lipopolysaccharide-induced stimulation of peritoneal macrophages involves at least two signal pathways. Partial stimulation by lipid A precursors.
European journal of biochemistry / FEBS 1989;179(3):589-94.
1989: H P Eck; H Gmünder; M Hartmann; Detlef Petzoldt; V Daniel; Wulf Dröge
Low concentrations of acid-soluble thiol (cysteine) in the blood plasma of HIV-1-infected patients.
Biological chemistry Hoppe-Seyler 1989;370(2):101-8.
1989: H P Eck; Wulf Dröge
Influence of the extracellular glutamate concentration on the intracellular cyst(e)ine concentration in macrophages and on the capacity to release cysteine.
Biological chemistry Hoppe-Seyler 1989;370(2):109-13.
1989: S Mihm; Angela Risso; M Stöhr; Franz Oberdorfer; Wulf Dröge
Downregulation of T cell growth factor production by ornithine decarboxylase and its product putrescine: D,L-alpha-difluoromethylornithine suppresses general protein synthesis but augments simultaneously the production of interleukin-2.
Experimental cell research 1989;180(2):383-98.
1989: H P Eck; H Frey; Wulf Dröge
Elevated plasma glutamate concentrations in HIV-1-infected patients may contribute to loss of macrophage and lymphocyte functions.
International immunology 1989;1(4):367-72.
1989: H P Eck; P Drings; Wulf Dröge
Plasma glutamate levels, lymphocyte reactivity and death rate in patients with bronchial carcinoma.
Journal of cancer research and clinical oncology 1989;115(6):571-4.
1988: Wulf Dröge; H P Eck; H Näher; U Pekar; V Daniel
Abnormal amino-acid concentrations in the blood of patients with acquired immunodeficiency syndrome (AIDS) may contribute to the immunological defect.
Biological chemistry Hoppe-Seyler 1988;369(3):143-8.
1988: Wulf Dröge; A Wehrmaker; H P Eck
Alanine inhibits cytotoxic responses: its production by different tumor cell lines explains differences in their immunogenicity.
Cancer detection and prevention 1988;11(3-6):151-6.
1988: Wulf Dröge; H P Eck; M Betzler; P Schlag; P Drings; W Ebert
Plasma glutamate concentration and lymphocyte activity.
Journal of cancer research and clinical oncology 1988;114(2):124-8.
1987: Wulf Dröge; H P Eck; M Betzler; H Näher
Elevated plasma glutamate levels in colorectal carcinoma patients and in patients with acquired immunodeficiency syndrome (AIDS).
Immunobiology 1987;174(4-5):473-9.
1987: H Kriegbaum; B Benninghoff; B Häcker-Shahin; Wulf Dröge
Correlation of immunogenicity and production of ornithine by peritoneal macrophages.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(3):899-904.
1987: Wulf Dröge; B Benninghoff; Volker Lehmann
Tumor necrosis factor augments the immunogenicity and the production of L-ornithine by peritoneal macrophages.
Lymphokine research 1987;6(2):111-7.
1986: A Wehrmaker; V Lehmann; Wulf Dröge
Analysis of protective and cytotoxic immune responses in vivo against metabolically inactivated and untreated cells of a mutagenized tumor line (requirements for tumor immunogenicity).
Cellular immunology 1986;101(2):290-8.
1986: Wulf Dröge; H P Eck; H Kriegbaum; S Mihm
Release of L-alanine by tumor cells.
Journal of immunology (Baltimore, Md. : 1950) 1986;137(4):1383-6.
1984: C Moyers; C Pottmeyer-Gerber; M Gerber; H Buszello; Wulf Dröge
Mitomycin C-treated or irradiated concanavalin A-activated T cells augment the activation of cytotoxic T cells in vivo.
Cellular immunology 1984;88(1):123-8.
1984: Wulf Dröge; C Moyers; A Wehrmaker; H Schmidt; S Panknin; D Männel; W Falk
Capacity of different cell types to stimulate cytotoxic T lymphocyte precursor cells in the presence of interleukin 2.
Journal of immunology (Baltimore, Md. : 1950) 1984;132(6):2749-59.