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Daniel Drucker

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Minsuk Kim; Mathew J Platt; Susan E Quaggin; Susumu Seino; Tadao Shibasaki; Jeremy A Simpson; Peter H Backx; Daniel J Drucker
GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure.
Mohammad Hossein Noyan Ashraf; Lisa Annette Robinson; Irmgard Schuiki; Eric Akihiko Shikatani; Allen Volchuk; Jun Wu; Filio Billia; Daniel J Drucker; Ren-Ke Li; Ilya Mukovozov; Mansoor Husain
A glucagon-like peptide-1 analog reverses the molecular pathology and cardiac dysfunction of a mouse model of obesity.
Naim Panjwani; Catherine Streutker; Bernardo Yusta; Dianne Holland; Christine Longuet; Erin E Mulvihill; Laurie L Baggio; Theodore J Brown; Jonathan E Campbell; Xiemin Cao; Daniel J Drucker
GLP-1 receptor activation indirectly reduces hepatic lipid accumulation but does not attenuate development of atherosclerosis in diabetic male ApoE(-/-) mice.

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All Publications

2013: Minsuk Kim; Mathew J Platt; Susan E Quaggin; Susumu Seino; Tadao Shibasaki; Jeremy A Simpson; Peter H Backx; Daniel J Drucker
GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure.
Nature medicine 2013;19(5):567-75.
2013: Mohammad Hossein Noyan Ashraf; Lisa Annette Robinson; Irmgard Schuiki; Eric Akihiko Shikatani; Allen Volchuk; Jun Wu; Filio Billia; Daniel J Drucker; Ren-Ke Li; Ilya Mukovozov; Mansoor Husain
A glucagon-like peptide-1 analog reverses the molecular pathology and cardiac dysfunction of a mouse model of obesity.
Circulation 2013;127(1):74-85.
2013: Naim Panjwani; Catherine Streutker; Bernardo Yusta; Dianne Holland; Christine Longuet; Erin E Mulvihill; Laurie L Baggio; Theodore J Brown; Jonathan E Campbell; Xiemin Cao; Daniel J Drucker
GLP-1 receptor activation indirectly reduces hepatic lipid accumulation but does not attenuate development of atherosclerosis in diabetic male ApoE(-/-) mice.
Endocrinology 2013;154(1):127-39.
2011: Jenny Barthson; Daniel J Drucker; Decio L Eizirik; Carla M Germano; Conny Gysemans; Andrea Jurisicova; Adriano Maida; Piero Marchetti; Chantal Mathieu; Fabrice Moore; Gabriel Nuñez; Esteban N Gurzov
Cytokines tumor necrosis factor-α and interferon-γ induce pancreatic β-cell apoptosis through STAT1-mediated Bim protein activation.
The Journal of biological chemistry 2011;286(45):39632-43.
2011: Daniel J Drucker; C F Rosen
Glucagon-like peptide-1 (GLP-1) receptor agonists, obesity and psoriasis: diabetes meets dermatology.
Diabetologia 2011;54(11):2741-4.
2011: Daniel J Drucker; Steven I Sherman; Richard M Bergenstal; John B Buse
The safety of incretin-based therapies--review of the scientific evidence.
The Journal of clinical endocrinology and metabolism 2011;96(7):2027-31.
2011: Daniel J Drucker; Allison B Goldfine
Cardiovascular safety and diabetes drug development.
Lancet 2011;377(9770):977-9.
2011: A Maida; B J Lamont; X Cao; Daniel J Drucker
Metformin regulates the incretin receptor axis via a pathway dependent on peroxisome proliferator-activated receptor-α in mice.
Diabetologia 2011;54(2):339-49.
2010: Jasmine Bahrami; Christine Longuet; Laurie L Baggio; Karen Li; Daniel J Drucker
Glucagon-like peptide-2 receptor modulates islet adaptation to metabolic stress in the ob/ob mouse.
Gastroenterology 2010;139(3):857-68.
2010: Jasmine Bahrami; Bernardo Yusta; Daniel J Drucker
ErbB activity links the glucagon-like peptide-2 receptor to refeeding-induced adaptation in the murine small bowel.
Gastroenterology 2010;138(7):2447-56.
2010: Daniel J Drucker; Argyris Dritselis; Peter Kirkpatrick
Liraglutide.
Nature reviews. Drug discovery 2010;9(4):267-8.
2010: J Hsieh; C Longuet; C L Baker; B Qin; L M Federico; Daniel J Drucker; Khosrow Adeli
The glucagon-like peptide 1 receptor is essential for postprandial lipoprotein synthesis and secretion in hamsters and mice.
Diabetologia 2010;53(3):552-61.
2010: Daniel J Drucker; Steven I Sherman; Fred S Gorelick; Richard M Bergenstal; Robert S Sherwin; John B Buse
Incretin-based therapies for the treatment of type 2 diabetes: evaluation of the risks and benefits.
Diabetes care 2010;33(2):428-33.
2009: Adriano Maida; Tanya Hansotia; Christine Longuet; Yutaka Seino; Daniel J Drucker
Differential importance of glucose-dependent insulinotropic polypeptide vs glucagon-like peptide 1 receptor signaling for beta cell survival in mice.
Gastroenterology 2009;137(6):2146-57.
2009: Denise D Belsham; Laura J Fick; Prasad S Dalvi; Maria-Luisa Centeno; Jennifer A Chalmers; Paul K P Lee; Yangyang Wang; Daniel J Drucker; Margaret M Koletar
Ciliary neurotrophic factor recruitment of glucagon-like peptide-1 mediates neurogenesis, allowing immortalization of adult murine hypothalamic neurons.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(12):4256-65.
2009: Bernardo Yusta; Dianne Holland; Jacqueline A Koehler; Marlena Maziarz; Jennifer L Estall; Rachel Higgins; Daniel J Drucker
ErbB signaling is required for the proliferative actions of GLP-2 in the murine gut.
Gastroenterology 2009;137(3):986-96.
2009: Jacqueline A Koehler; Laurie L Baggio; Benjamin J Lamont; Safina Ali; Daniel J Drucker
Glucagon-like peptide-1 receptor activation modulates pancreatitis-associated gene expression but does not modify the susceptibility to experimental pancreatitis in mice.
Diabetes 2009;58(9):2148-61.
2009: JA Lovshin; Daniel J Drucker
Incretin-based therapies for type 2 diabetes mellitus.
Nature reviews. Endocrinology 2009;5(5):262-9.
2009: Irene Hadjiyanni; Kunmin Karen Li; Daniel J Drucker
Glucagon-like peptide-2 reduces intestinal permeability but does not modify the onset of type 1 diabetes in the nonobese diabetic mouse.
Endocrinology 2009;150(2):592-9.
2009: Hélène Duez; Angela C Smith; Changting Xiao; Adria Giacca; Linda Szeto; Daniel J Drucker; Gary F Lewis
Acute dipeptidyl peptidase-4 inhibition rapidly enhances insulin-mediated suppression of endogenous glucose production in mice.
Endocrinology 2009;150(1):56-62.
2008: Christine Longuet; Elaine M Sinclair; Adriano Maida; Laurie L Baggio; Marlena Maziarz; Maureen J Charron; Daniel J Drucker
The glucagon receptor is required for the adaptive metabolic response to fasting.
Cell metabolism 2008;8(5):359-71.
2008: Jacqueline A Koehler; Will Harper; Maja Barnard; Bernardo Yusta; Daniel J Drucker
Glucagon-like peptide-2 does not modify the growth or survival of murine or human intestinal tumor cells.
Cancer research 2008;68(19):7897-904.
2008: Satish Patel; Bradley Doble; Katrina MacAulay; Elaine M Sinclair; Daniel J Drucker; James R Woodgett
Tissue-specific role of glycogen synthase kinase 3beta in glucose homeostasis and insulin action.
Molecular and cellular biology 2008;28(20):6314-28.
2008: Ravi Retnakaran; Daniel J Drucker
Intensive insulin therapy in newly diagnosed type 2 diabetes.
Lancet 2008;371(9626):1725-6.
2008: Kiwon Ban; M Hossein Noyan-Ashraf; Judith Hoefer; Steffen-Sebastian Bolz; Daniel J Drucker; Mansoor Husain
Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways.
Circulation 2008;117(18):2340-50.
2008: Irene Hadjiyanni; Laurie L Baggio; Philippe Poussier; Daniel J Drucker
Exendin-4 modulates diabetes onset in nonobese diabetic mice.
Endocrinology 2008;149(3):1338-49.
2008: Julio E Ayala; Deanna P Bracy; Tanya Hansotia; Grace Flock; Yutaka Seino; David H Wasserman; Daniel J Drucker
Insulin action in the double incretin receptor knockout mouse.
Diabetes 2008;57(2):288-97.
2007: Rhonda D Wideman; Scott D Covey; Gene C Webb; Daniel J Drucker; Timothy J Kieffer
A switch from prohormone convertase (PC)-2 to PC1/3 expression in transplanted alpha-cells is accompanied by differential processing of proglucagon and improved glucose homeostasis in mice.
Diabetes 2007;56(11):2744-52.
2007: Katrina MacAulay; Bradley Doble; Satish Patel; Tanya Hansotia; Elaine M Sinclair; Daniel J Drucker; Andras Nagy; James R Woodgett
Glycogen synthase kinase 3alpha-specific regulation of murine hepatic glycogen metabolism.
Cell metabolism 2007;6(4):329-37.
2007: Daniel J Drucker
Dipeptidyl peptidase-4 inhibition and the treatment of type 2 diabetes: preclinical biology and mechanisms of action.
Diabetes care 2007;30(6):1335-43.
2007: Daniel J Drucker
The role of gut hormones in glucose homeostasis.
The Journal of clinical investigation 2007;117(1):24-32.
2007: Tanya Hansotia; Adriano Maida; Grace Flock; Yuichiro Yamada; Katsushi Tsukiyama; Yutaka Seino; Daniel J Drucker
Extrapancreatic incretin receptors modulate glucose homeostasis, body weight, and energy expenditure.
The Journal of clinical investigation 2007;117(1):143-52.
2006: Daniel J Drucker; Michael A Nauck
The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes.
Lancet 2006;368(9548):1696-705.
2006: Bernardo Yusta; Laurie L Baggio; Jennifer L Estall; Jacqueline A Koehler; Dianne P Holland; Hongyun Li; Danny Pipeleers; Zhidong Ling; Daniel J Drucker
GLP-1 receptor activation improves beta cell function and survival following induction of endoplasmic reticulum stress.
Cell metabolism 2006;4(5):391-406.
2006: Daniel J Drucker
Enhancing the action of incretin hormones: a new whey forward?
Endocrinology 2006;147(7):3171-2.
2006: Jacqueline A Koehler; Daniel J Drucker
Activation of glucagon-like peptide-1 receptor signaling does not modify the growth or apoptosis of human pancreatic cancer cells.
Diabetes 2006;55(5):1369-79.
2006: Daniel J Drucker
The evidence for achieving glycemic control with incretin mimetics.
The Diabetes educator 2006;32 Suppl 2():72S-81S.
2006: Daniel J Drucker
Incretin-based therapies: a clinical need filled by unique metabolic effects.
The Diabetes educator 2006;32 Suppl 2():65S-71S.
2006: Daniel J Drucker
The biology of incretin hormones.
Cell metabolism 2006;3(3):153-65.
2006: Jennifer L Estall; Daniel J Drucker
Glucagon and glucagon-like peptide receptors as drug targets.
Current pharmaceutical design 2006;12(14):1731-50.
2006: Jennifer L Estall; Daniel J Drucker
Glucagon-like Peptide-2.
Annual review of nutrition 2006;26():391-411.
2006: Laurie L Baggio; Daniel J Drucker
Therapeutic approaches to preserve islet mass in type 2 diabetes.
Annual review of medicine 2006;57():265-81.
2005: Daniel J Drucker
Does exenatide provide a meaningful new treatment option for patients with type 2 diabetes?
Nature clinical practice. Endocrinology & metabolism 2005;1(2):70-1.
2005: Elaine M Sinclair; Daniel J Drucker
Proglucagon-derived peptides: mechanisms of action and therapeutic potential.
Physiology (Bethesda, Md.) 2005;20():357-65.
2005: Tanvi Talsania; Younes Anini; Stephanie Siu; Daniel J Drucker; Patricia L Brubaker
Peripheral exendin-4 and peptide YY(3-36) synergistically reduce food intake through different mechanisms in mice.
Endocrinology 2005;146(9):3748-56.
2005: Tanya Hansotia; Daniel J Drucker
GIP and GLP-1 as incretin hormones: lessons from single and double incretin receptor knockout mice.
Regulatory peptides 2005;128(2):125-34.
2005: Jennifer L Estall; Jacqueline A Koehler; Bernardo Yusta; Daniel J Drucker
The glucagon-like peptide-2 receptor C terminus modulates beta-arrestin-2 association but is dispensable for ligand-induced desensitization, endocytosis, and G-protein-dependent effector activation.
The Journal of biological chemistry 2005;280(23):22124-34.
2005: Eric D Shin; Jennifer L Estall; Angelo Izzo; Daniel J Drucker; Patricia L Brubaker
Mucosal adaptation to enteral nutrients is dependent on the physiologic actions of glucagon-like peptide-2 in mice.
Gastroenterology 2005;128(5):1340-53.
2005: Marlena Maziarz; Clement Chung; Daniel J Drucker; Andrew Emili
Integrating global proteomic and genomic expression profiles generated from islet alpha cells: opportunities and challenges to deriving reliable biological inferences.
Molecular & cellular proteomics : MCP 2005;4(4):458-74.
2005: Yazhou Li; Xiemin Cao; Li-Xin Li; Patricia L Brubaker; Ulla Edlund; Daniel J Drucker
beta-Cell Pdx1 expression is essential for the glucoregulatory, proliferative, and cytoprotective actions of glucagon-like peptide-1.
Diabetes 2005;54(2):482-91.
2005: Jacqueline A Koehler; Bernardo Yusta; Daniel J Drucker
The HeLa cell glucagon-like peptide-2 receptor is coupled to regulation of apoptosis and ERK1/2 activation through divergent signaling pathways.
Molecular endocrinology (Baltimore, Md.) 2005;19(2):459-73.
2005: Jennifer L Estall; Daniel J Drucker
Tales beyond the crypt: glucagon-like peptide-2 and cytoprotection in the intestinal mucosa.
Endocrinology 2005;146(1):19-21.
2005: Grace Flock; Xiemin Cao; Daniel J Drucker
Pdx-1 is not sufficient for repression of proglucagon gene transcription in islet or enteroendocrine cells.
Endocrinology 2005;146(1):441-9.
2004: Laurie L Baggio; Jung-Guk Kim; Daniel J Drucker
Chronic exposure to GLP-1R agonists promotes homologous GLP-1 receptor desensitization in vitro but does not attenuate GLP-1R-dependent glucose homeostasis in vivo.
Diabetes 2004;53 Suppl 3():S205-14.
2004: Laurie L Baggio; Daniel J Drucker
Clinical endocrinology and metabolism. Glucagon-like peptide-1 and glucagon-like peptide-2.
Best practice & research. Clinical endocrinology & metabolism 2004;18(4):531-54.
2004: Laurie L Baggio; Qingling Huang; Theodore J Brown; Daniel J Drucker
Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure.
Gastroenterology 2004;127(2):546-58.
2004: Jennifer L Estall; Bernardo Yusta; Daniel J Drucker
Lipid raft-dependent glucagon-like peptide-2 receptor trafficking occurs independently of agonist-induced desensitization.
Molecular biology of the cell 2004;15(8):3673-87.
2004: JA Lovshin; Qingling Huang; Raewyn M Seaberg; Patricia L Brubaker; Daniel J Drucker
Extrahypothalamic expression of the glucagon-like peptide-2 receptor is coupled to reduction of glutamate-induced cell death in cultured hippocampal cells.
Endocrinology 2004;145(7):3495-506.
2004: Patricia L Brubaker; Daniel J Drucker
Minireview: Glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system.
Endocrinology 2004;145(6):2653-9.
2004: Tanya Hansotia; Laurie L Baggio; Dominique Delmeire; Simon Hinke; Yuichiro Yamada; Katsushi Tsukiyama; Yutaka Seino; Jens J Holst; Frans Schuit; Daniel J Drucker
Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors.
Diabetes 2004;53(5):1326-35.
2003: Daniel J Drucker
Glucagon-like peptide-1 and the islet beta-cell: augmentation of cell proliferation and inhibition of apoptosis.
Endocrinology 2003;144(12):5145-8.
2003: Jennifer L Estall; Daniel J Drucker
Dual regulation of cell proliferation and survival via activation of glucagon-like peptide-2 receptor signaling.
The Journal of nutrition 2003;133(11):3708-11.
2003: Robin P Boushey; Amir Abadir; Daisy Flamez; Laurie L Baggio; Yazhou Li; Veerle Berger; Bess A Marshall; Diane Finegood; Timothy C Wang; Frans Schuit; Daniel J Drucker
Hypoglycemia, defective islet glucagon secretion, but normal islet mass in mice with a disruption of the gastrin gene.
Gastroenterology 2003;125(4):1164-74.
2003: Daniel J Drucker
Enhancing incretin action for the treatment of type 2 diabetes.
Diabetes care 2003;26(10):2929-40.
2003: Natalie A Walsh; Bernardo Yusta; Mark P DaCambra; Younes Anini; Daniel J Drucker; Patricia L Brubaker
Glucagon-like peptide-2 receptor activation in the rat intestinal mucosa.
Endocrinology 2003;144(10):4385-92.
2003: Robert Gros; Xiaomang You; Laurie L Baggio; golam kabir; Al Muktafi Sadi; Imran N Mungrue; Thomas G Parker; Qingling Huang; Daniel J Drucker; Mansoor Husain
Cardiac function in mice lacking the glucagon-like peptide-1 receptor.
Endocrinology 2003;144(6):2242-52.
2003: Xiemin Cao; Grace Flock; Caroline Choi; David M Irwin; Daniel J Drucker
Aberrant regulation of human intestinal proglucagon gene expression in the NCI-H716 cell line.
Endocrinology 2003;144(5):2025-33.
2003: Jung-Guk Kim; Laurie L Baggio; Dominique Bridon; Jean-Paul Castaigne; Martin Robitaille; Lucie Jetté; Corinne Benquet; Daniel J Drucker
Development and characterization of a glucagon-like peptide 1-albumin conjugate: the ability to activate the glucagon-like peptide 1 receptor in vivo.
Diabetes 2003;52(3):751-9.
2003: Daniel J Drucker
Glucagon-like peptides: regulators of cell proliferation, differentiation, and apoptosis.
Molecular endocrinology (Baltimore, Md.) 2003;17(2):161-71.
2003: Denny K Y Trinh; Kai Zhang; Moazzem Hossain; Patricia L Brubaker; Daniel J Drucker
Pax-6 activates endogenous proglucagon gene expression in the rodent gastrointestinal epithelium.
Diabetes 2003;52(2):425-33.
2003: Yazhou Li; Tanya Hansotia; Bernardo Yusta; Frédéric Ris; Philippe A Halban; Daniel J Drucker
Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis.
The Journal of biological chemistry 2003;278(1):471-8.
2003: Daniel J Drucker
Therapeutic potential of dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes.
Expert opinion on investigational drugs 2003;12(1):87-100.
2002: Grace Flock; Daniel J Drucker
Pax-2 activates the proglucagon gene promoter but is not essential for proglucagon gene expression or development of proglucagon-producing cell lineages in the murine pancreas or intestine.
Molecular endocrinology (Baltimore, Md.) 2002;16(10):2349-59.
2002: Feisal A Adatia; Laurie L Baggio; Q Xiao; Daniel J Drucker; Patricia L Brubaker
Cellular specificity of proexendin-4 processing in mammalian cells in vitro and in vivo.
Endocrinology 2002;143(9):3464-71.
2002: Yuanfang Liu; Wei Shen; Patricia L Brubaker; Klaus kaestner; Daniel J Drucker
Foxa3 (HNF-3gamma) binds to and activates the rat proglucagon gene promoter but is not essential for proglucagon gene expression.
The Biochemical journal 2002;366(Pt 2):633-41.
2002: Bernardo Yusta; Jennifer L Estall; Daniel J Drucker
Glucagon-like peptide-2 receptor activation engages bad and glycogen synthase kinase-3 in a protein kinase A-dependent manner and prevents apoptosis following inhibition of phosphatidylinositol 3-kinase.
The Journal of biological chemistry 2002;277(28):24896-906.
2002: Patricia L Brubaker; Daniel J Drucker; Sylvia Asa; Carol J Swallow; Mark Redston; Gordon R Greenberg
Prolonged gastrointestinal transit in a patient with a glucagon-like peptide (GLP)-1- and -2-producing neuroendocrine tumor.
The Journal of clinical endocrinology and metabolism 2002;87(7):3078-83.
2002: Daniel J Drucker
Gut adaptation and the glucagon-like peptides.
Gut 2002;50(3):428-35.
2002: Daniel J Drucker
Biological actions and therapeutic potential of the glucagon-like peptides.
Gastroenterology 2002;122(2):531-44.
2002: Laurie L Baggio; Daniel J Drucker
Harnessing the therapeutic potential of glucagon-like peptide-1: a critical review.
Treatments in endocrinology 2002;1(2):117-25.
2002: Patricia L Brubaker; Daniel J Drucker
Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors.
Receptors & channels 2002;8(3-4):179-88.
2002: Min Nian; Jun Gu; David M Irwin; Daniel J Drucker
Human glucagon gene promoter sequences regulating tissue-specific versus nutrient-regulated gene expression.
American journal of physiology. Regulatory, integrative and comparative physiology 2002;282(1):R173-83.
2001: Daniel J Drucker
Development of glucagon-like peptide-1-based pharmaceuticals as therapeutic agents for the treatment of diabetes.
Current pharmaceutical design 2001;7(14):1399-412.
2001: JA Lovshin; Jennifer L Estall; Bernardo Yusta; Theodore J Brown; Daniel J Drucker
Glucagon-like peptide (GLP)-2 action in the murine central nervous system is enhanced by elimination of GLP-1 receptor signaling.
The Journal of biological chemistry 2001;276(24):21489-99.
2001: Zhidong Ling; D Wu; Y Zambre; Daisy Flamez; Daniel J Drucker; Daniel G Pipeleers; Frans Schuit
Glucagon-like peptide 1 receptor signaling influences topography of islet cells in mice.
Virchows Archiv : an international journal of pathology 2001;438(4):382-7.
2001: Daniel J Drucker
Glucagon-like peptide 2.
The Journal of clinical endocrinology and metabolism 2001;86(4):1759-64.
2001: Daniel J Drucker
Minireview: the glucagon-like peptides.
Endocrinology 2001;142(2):521-7.
2001: Robin P Boushey; Bernardo Yusta; Daniel J Drucker
Glucagon-like peptide (GLP)-2 reduces chemotherapy-associated mortality and enhances cell survival in cells expressing a transfected GLP-2 receptor.
Cancer research 2001;61(2):687-93.
2000: Bernardo Yusta; Robin P Boushey; Daniel J Drucker
The glucagon-like peptide-2 receptor mediates direct inhibition of cellular apoptosis via a cAMP-dependent protein kinase-independent pathway.
The Journal of biological chemistry 2000;275(45):35345-52.
2000: Laurie L Baggio; Feisal A Adatia; T Bock; Patricia L Brubaker; Daniel J Drucker
Sustained expression of exendin-4 does not perturb glucose homeostasis, beta-cell mass, or food intake in metallothionein-preproexendin transgenic mice.
The Journal of biological chemistry 2000;275(44):34471-7.
2000: JA Lovshin; Bernardo Yusta; I Iliopoulos; A Migirdicyan; L Dableh; Patricia L Brubaker; Daniel J Drucker
Ontogeny of the glucagon-like peptide-2 receptor axis in the developing rat intestine.
Endocrinology 2000;141(11):4194-201.
2000: Laurie L Baggio; T J Kieffer; Daniel J Drucker
Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, regulates fasting glycemia and nonenteral glucose clearance in mice.
Endocrinology 2000;141(10):3703-9.
2000: Bernardo Yusta; L Huang; DG Munroe; G Wolff; R Fantaske; S Sharma; L Demchyshyn; Sylvia Asa; Daniel J Drucker
Enteroendocrine localization of GLP-2 receptor expression in humans and rodents.
Gastroenterology 2000;119(3):744-55.
2000: Louise A Scrocchi; M E Hill; J Saleh; B Perkins; Daniel J Drucker
Elimination of glucagon-like peptide 1R signaling does not modify weight gain and islet adaptation in mice with combined disruption of leptin and GLP-1 action.
Diabetes 2000;49(9):1552-60.
2000: M P DaCambra; Bernardo Yusta; M Sumner-Smith; A Crivici; Daniel J Drucker; Patricia L Brubaker
Structural determinants for activity of glucagon-like peptide-2.
Biochemistry 2000;39(30):8888-94.
2000: Q Xiao; Robin P Boushey; M Cino; Daniel J Drucker; Patricia L Brubaker
Circulating levels of glucagon-like peptide-2 in human subjects with inflammatory bowel disease.
American journal of physiology. Regulatory, integrative and comparative physiology 2000;278(4):R1057-63.
2000: JA Lovshin; Daniel J Drucker
Synthesis, secretion and biological actions of the glucagon-like peptides.
Pediatric diabetes 2000;1(1):49-57.
2000: Neil J MacLusky; S Cook; Louise A Scrocchi; J Shin; J Kim; Franco J Vaccarino; Sylvia Asa; Daniel J Drucker
Neuroendocrine function and response to stress in mice with complete disruption of glucagon-like peptide-1 receptor signaling.
Endocrinology 2000;141(2):752-62.
2000: Daniel J Drucker; JA Lovshin; Laurie L Baggio; Min Nian; Feisal A Adatia; Robin P Boushey; Y Liu; J Saleh; Bernardo Yusta; Louise A Scrocchi
New developments in the biology of the glucagon-like peptides GLP-1 and GLP-2.
Annals of the New York Academy of Sciences 2000;921():226-32.
2000: W Tavares; Daniel J Drucker; Patricia L Brubaker
Enzymatic- and renal-dependent catabolism of the intestinotropic hormone glucagon-like peptide-2 in rats.
American journal of physiology. Endocrinology and metabolism 2000;278(1):E134-9.
1999: Robin P Boushey; Bernardo Yusta; Daniel J Drucker
Glucagon-like peptide 2 decreases mortality and reduces the severity of indomethacin-induced murine enteritis.
The American journal of physiology 1999;277(5 Pt 1):E937-47.
1999: Bernardo Yusta; Romel Somwar; F Wang; DG Munroe; Sergio Grinstein; Amira Klip; Daniel J Drucker
Identification of glucagon-like peptide-2 (GLP-2)-activated signaling pathways in baby hamster kidney fibroblasts expressing the rat GLP-2 receptor.
The Journal of biological chemistry 1999;274(43):30459-67.
1999: Daisy Flamez; Patrick Gilon; Karen Moens; A Van Breusegem; Dominique Delmeire; LA Scrocchi; Jean-Claude Henquin; Daniel J Drucker; Frans Schuit
Altered cAMP and Ca2+ signaling in mouse pancreatic islets with glucagon-like peptide-1 receptor null phenotype.
Diabetes 1999;48(10):1979-86.
1999: Daniel J Drucker; Robin P Boushey; F Wang; M E Hill; Patricia L Brubaker; Bernardo Yusta
Biologic properties and therapeutic potential of glucagon-like peptide-2.
JPEN. Journal of parenteral and enteral nutrition 1999;23(5 Suppl):S98-100.
1999: M E Hill; Sylvia Asa; Daniel J Drucker
Essential requirement for Pax6 in control of enteroendocrine proglucagon gene transcription.
Molecular endocrinology (Baltimore, Md.) 1999;13(9):1474-86.
1999: Q Xiao; Robin P Boushey; Daniel J Drucker; Patricia L Brubaker
Secretion of the intestinotropic hormone glucagon-like peptide 2 is differentially regulated by nutrients in humans.
Gastroenterology 1999;117(1):99-105.
1999: K Y Trinh; Tianru Jin; Daniel J Drucker
Identification of domains mediating transcriptional activation and cytoplasmic export in the caudal homeobox protein Cdx-3.
The Journal of biological chemistry 1999;274(9):6011-9.
1999: DG Munroe; A K Gupta; F Kooshesh; T B Vyas; Geihan Rizkalla; Hua Wang; Lidia Demchyshyn; Z J Yang; Rajender K Kamboj; H Chen; KL McCallum; M Sumner-Smith; Daniel J Drucker; A Crivici
Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(4):1569-73.
1999: Daniel J Drucker; Bernardo Yusta; Robin P Boushey; L DeForest; Patricia L Brubaker
Human [Gly2]GLP-2 reduces the severity of colonic injury in a murine model of experimental colitis.
The American journal of physiology 1999;276(1 Pt 1):G79-91.
1998: Patricia L Brubaker; J Schloos; Daniel J Drucker
Regulation of glucagon-like peptide-1 synthesis and secretion in the GLUTag enteroendocrine cell line.
Endocrinology 1998;139(10):4108-14.
1998: Raymond A Pederson; Malathy Satkunarajah; Christopher H S McIntosh; LA Scrocchi; Daisy Flamez; Frans Schuit; Daniel J Drucker; Michael B Wheeler
Enhanced glucose-dependent insulinotropic polypeptide secretion and insulinotropic action in glucagon-like peptide 1 receptor -/- mice.
Diabetes 1998;47(7):1046-52.
1998: Louise A Scrocchi; Daniel J Drucker
Effects of aging and a high fat diet on body weight and glucose tolerance in glucagon-like peptide-1 receptor -/- mice.
Endocrinology 1998;139(7):3127-32.
1998: Daisy Flamez; A Van Breusegem; LA Scrocchi; Erik Quartier; Daniel Pipeleers; Daniel J Drucker; Frans Schuit
Mouse pancreatic beta-cells exhibit preserved glucose competence after disruption of the glucagon-like peptide-1 receptor gene.
Diabetes 1998;47(4):646-52.
1998: Louise A Scrocchi; Bess A Marshall; S M Cook; Patricia L Brubaker; Daniel J Drucker
Identification of glucagon-like peptide 1 (GLP-1) actions essential for glucose homeostasis in mice with disruption of GLP-1 receptor signaling.
Diabetes 1998;47(4):632-9.
1998: Daniel J Drucker
Glucagon-like peptides.
Diabetes 1998;47(2):159-69.
1997: Daniel J Drucker; L DeForest; Patricia L Brubaker
Intestinal response to growth factors administered alone or in combination with human [Gly2]glucagon-like peptide 2.
The American journal of physiology 1997;273(6 Pt 1):G1252-62.
1997: Louise A Scrocchi; Theodore J Brown; Daniel J Drucker
Leptin sensitivity in nonobese glucagon-like peptide I receptor -/- mice.
Diabetes 1997;46(12):2029-34.
1997: Patricia L Brubaker; A Crivici; Angelo Izzo; P Ehrlich; CH Tsai; Daniel J Drucker
Circulating and tissue forms of the intestinal growth factor, glucagon-like peptide-2.
Endocrinology 1997;138(11):4837-43.
1997: Klaus-Dieter Fischer; Savita Dhanvantari; Daniel J Drucker; Patricia L Brubaker
Intestinal growth is associated with elevated levels of glucagon-like peptide 2 in diabetic rats.
The American journal of physiology 1997;273(4 Pt 1):E815-20.
1997: Daniel J Drucker
Epithelial cell growth and differentiation. I. Intestinal growth factors.
The American journal of physiology 1997;273(1 Pt 1):G3-6.
1997: CH Tsai; M Hill; Sylvia Asa; Patricia L Brubaker; Daniel J Drucker
Intestinal growth-promoting properties of glucagon-like peptide-2 in mice.
The American journal of physiology 1997;273(1 Pt 1):E77-84.
1997: Daniel J Drucker; Q Shi; A Crivici; M Sumner-Smith; W Tavares; M Hill; L DeForest; S Cooper; Patricia L Brubaker
Regulation of the biological activity of glucagon-like peptide 2 in vivo by dipeptidyl peptidase IV.
Nature biotechnology 1997;15(7):673-7.
1997: Patricia L Brubaker; Angelo Izzo; M Hill; Daniel J Drucker
Intestinal function in mice with small bowel growth induced by glucagon-like peptide-2.
The American journal of physiology 1997;272(6 Pt 1):E1050-8.
1997: CH Tsai; M Hill; Daniel J Drucker
Biological determinants of intestinotrophic properties of GLP-2 in vivo.
The American journal of physiology 1997;272(3 Pt 1):G662-8.
1997: Chen Lab; Daniel J Drucker
Tissue-specific expression of unique mRNAs that encode proglucagon-derived peptides or exendin 4 in the lizard.
The Journal of biological chemistry 1997;272(7):4108-15.
1997: Tianru Jin; Denny K Y Trinh; F Wang; Daniel J Drucker
The caudal homeobox protein cdx-2/3 activates endogenous proglucagon gene expression in InR1-G9 islet cells.
Molecular endocrinology (Baltimore, Md.) 1997;11(2):203-9.
1996: Louise A Scrocchi; T J Brown; N MaClusky; Patricia L Brubaker; A B Auerbach; Alexandra L Joyner; Daniel J Drucker
Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene.
Nature medicine 1996;2(11):1254-8.
1996: F Lü; Tianru Jin; Daniel J Drucker
Proglucagon gene expression is induced by gastrin-releasing peptide in a mouse enteroendocrine cell line.
Endocrinology 1996;137(9):3710-6.
1996: ZQ Shi; K S Rastogi; Michael Lekas; Suad Efendic; Daniel J Drucker; Mladen Vranic
Glucagon response to hypoglycemia is improved by insulin-independent restoration of normoglycemia in diabetic rats.
Endocrinology 1996;137(8):3193-9.
1996: T Petrocelli; R Poon; Daniel J Drucker; Joyce M Slingerland; Cheryl F Rosen
UVB radiation induces p21Cip1/WAF1 and mediates G1 and S phase checkpoints.
Oncogene 1996;12(7):1387-96.
1996: Tianru Jin; Daniel J Drucker
Activation of proglucagon gene transcription through a novel promoter element by the caudal-related homeodomain protein cdx-2/3.
Molecular and cellular biology 1996;16(1):19-28.
1995: Tianru Jin; Daniel J Drucker
The proglucagon gene upstream enhancer contains positive and negative domains important for tissue-specific proglucagon gene transcription.
Molecular endocrinology (Baltimore, Md.) 1995;9(10):1306-20.
1995: M Wang; Daniel J Drucker
The LIM domain homeobox gene isl-1 is a positive regulator of islet cell-specific proglucagon gene transcription.
The Journal of biological chemistry 1995;270(21):12646-52.
1995: Cheryl F Rosen; R Poon; Daniel J Drucker
UVB radiation-activated genes induced by transcriptional and posttranscriptional mechanisms in rat keratinocytes.
The American journal of physiology 1995;268(4 Pt 1):C846-55.
1994: R V Campos; L Zhang; Daniel J Drucker
Differential expression of RNA transcripts encoding unique carboxy-terminal sequences of human parathyroid hormone-related peptide.
Molecular endocrinology (Baltimore, Md.) 1994;8(12):1656-66.
1994: Daniel J Drucker; Tianru Jin; Sylvia Asa; T A Young; Patricia L Brubaker
Activation of proglucagon gene transcription by protein kinase-A in a novel mouse enteroendocrine cell line.
Molecular endocrinology (Baltimore, Md.) 1994;8(12):1646-55.
1994: P Ehrlich; D Tucker; Sylvia Asa; Patricia L Brubaker; Daniel J Drucker
Inhibition of pancreatic proglucagon gene expression in mice bearing subcutaneous endocrine tumors.
The American journal of physiology 1994;267(5 Pt 1):E662-71.
1994: Daniel J Drucker
Molecular pathophysiology of glucagon-SV40 T antigen transgenic mice.
The American journal of physiology 1994;267(5 Pt 1):E629-35.
1994: R V Campos; Y C Lee; Daniel J Drucker
Divergent tissue-specific and developmental expression of receptors for glucagon and glucagon-like peptide-1 in the mouse.
Endocrinology 1994;134(5):2156-64.
1994: X Li; Daniel J Drucker
Parathyroid hormone-related peptide is a downstream target for ras and src activation.
The Journal of biological chemistry 1994;269(9):6263-6.
1994: M Wang; Daniel J Drucker
The LIM domain homeobox gene isl-1: conservation of human, hamster, and rat complementary deoxyribonucleic acid sequences and expression in cell types of nonneuroendocrine lineage.
Endocrinology 1994;134(3):1416-22.
1993: Tania Roskams; M Willems; R V Campos; Daniel J Drucker; Sing Hiem Yap; Valeer Desmet
Parathyroid hormone-related peptide expression in primary and metastatic liver tumours.
Histopathology 1993;23(6):519-25.
1993: Tania Roskams; R V Campos; Daniel J Drucker; Valeer Desmet
Reactive human bile ductules express parathyroid hormone-related peptide.
Histopathology 1993;23(1):11-9.
1993: Y C Lee; R V Campos; Daniel J Drucker
Region- and age-specific differences in proglucagon gene expression in the central nervous system of wild-type and glucagon-simian virus-40 T-antigen transgenic mice.
Endocrinology 1993;133(1):171-7.
1993: X Li; Daniel J Drucker
Growth factor-like properties of parathyroid hormone-related peptide in transfected rodent cell line.
Cancer research 1993;53(13):2980-6.
1993: D Gajic; Daniel J Drucker
Multiple cis-acting domains mediate basal and adenosine 3',5'-monophosphate-dependent glucagon gene transcription in a mouse neuroendocrine cell line.
Endocrinology 1993;132(3):1055-62.
1992: Daniel J Drucker; Y C Lee; Sylvia Asa; Patricia L Brubaker
Inhibition of pancreatic glucagon gene expression in mice bearing a subcutaneous glucagon-producing GLUTag transplantable tumor.
Molecular endocrinology (Baltimore, Md.) 1992;6(12):2175-84.
1992: Cheryl F Rosen; D Gajic; Q Jia; Daniel J Drucker
Interaction of TPA and ultraviolet B radiation in regulation of ODC gene expression in rat keratinocytes.
The American journal of physiology 1992;263(5 Pt 1):C1103-10.
1992: Patricia L Brubaker; Y C Lee; Daniel J Drucker
Alterations in proglucagon processing and inhibition of proglucagon gene expression in transgenic mice which contain a chimeric proglucagon-SV40 T antigen gene.
The Journal of biological chemistry 1992;267(29):20728-33.
1992: R V Campos; C Wang; Daniel J Drucker
Regulation of parathyroid hormone-related peptide (PTHrP) gene transcription: cell- and tissue-specific promoter utilization mediated by multiple positive and negative cis-acting DNA elements.
Molecular endocrinology (Baltimore, Md.) 1992;6(10):1642-52.
1992: E T Allinson; Daniel J Drucker
Parathyroid hormone-like peptide shares features with members of the early response gene family: rapid induction by serum, growth factors, and cycloheximide.
Cancer research 1992;52(11):3103-9.
1992: Y C Lee; Sylvia Asa; Daniel J Drucker
Glucagon gene 5'-flanking sequences direct expression of simian virus 40 large T antigen to the intestine, producing carcinoma of the large bowel in transgenic mice.
The Journal of biological chemistry 1992;267(15):10705-8.
1991: R V Campos; Sylvia Asa; Daniel J Drucker
Immunocytochemical localization of parathyroid hormone-like peptide in the rat fetus.
Cancer research 1991;51(23 Pt 1):6351-7.
1991: Patricia L Brubaker; Daniel J Drucker; Sylvia Asa; Gordon R Greenberg
Regulation of peptide-YY synthesis and secretion in fetal rat intestinal cultures.
Endocrinology 1991;129(6):3351-8.
1991: J Dong; Sylvia Asa; Daniel J Drucker
Islet cell and extrapancreatic expression of the LIM domain homeobox gene isl-1.
Molecular endocrinology (Baltimore, Md.) 1991;5(11):1633-41.
1991: C Streutker; Daniel J Drucker
Rapid induction of parathyroid hormone-like peptide gene expression by sodium butyrate in a rat islet cell line.
Molecular endocrinology (Baltimore, Md.) 1991;5(5):703-8.
1991: C Wang; R V Campos; K M Stobie; Patricia L Brubaker; Daniel J Drucker
Differential glucocorticoid regulation of glucagon gene expression in cell lines derived from rat and hamster islet cell tumors.
Cancer research 1991;51(4):1196-201.
1991: Daniel J Drucker; R Campos; R Reynolds; K Stobie; Patricia L Brubaker
The rat glucagon gene is regulated by a protein kinase A-dependent pathway in pancreatic islet cells.
Endocrinology 1991;128(1):394-400.
1991: Patricia L Brubaker; K M Stobie; J N Roberge; E Y Lui; Daniel J Drucker
Proglucagon-derived peptides in the neuroendocrine system.
Advances in experimental medicine and biology 1991;291():143-59.
1990: Y C Lee; Patricia L Brubaker; Daniel J Drucker
Developmental and tissue-specific regulation of proglucagon gene expression.
Endocrinology 1990;127(5):2217-22.
1990: Cheryl F Rosen; D Gajic; Q Jia; Daniel J Drucker
Ultraviolet B radiation induction of ornithine decarboxylase gene expression in mouse epidermis.
The Biochemical journal 1990;270(3):565-8.
1990: Daniel J Drucker
Glucagon and the glucagon-like peptides.
Pancreas 1990;5(4):484-8.
1990: Y C Lee; Daniel J Drucker
Glucagon gene 3'-flanking sequences direct formation of proglucagon messenger RNA 3'-ends in islet and nonislet cells lines.
Molecular endocrinology (Baltimore, Md.) 1990;4(6):800-6.
1990: Patricia L Brubaker; Daniel J Drucker; Gordon R Greenberg
Synthesis and secretion of somatostatin-28 and -14 by fetal rat intestinal cells in culture.
The American journal of physiology 1990;258(6 Pt 1):G974-81.
1990: Cheryl F Rosen; D Gajic; Daniel J Drucker
Ultraviolet radiation induction of ornithine decarboxylase in rat keratinocytes.
Cancer research 1990;50(9):2631-5.
1990: Daniel J Drucker; Sylvia Asa; J Silverberg; Patricia L Brubaker
Molecular and cellular analysis of a neoplastic pancreatic A cell tumor.
Cancer 1990;65(8):1762-70.
1990: E Y Lui; Sylvia Asa; Daniel J Drucker; Y C Lee; Patricia L Brubaker
Glucagon and related peptides in fetal rat hypothalamus in vivo and in vitro.
Endocrinology 1990;126(1):110-7.
1989: Daniel J Drucker; Sylvia Asa; J Henderson; D Goltzman
The parathyroid hormone-like peptide gene is expressed in the normal and neoplastic human endocrine pancreas.
Molecular endocrinology (Baltimore, Md.) 1989;3(10):1589-95.
1989: Patricia L Brubaker; D C So; Daniel J Drucker
Tissue-specific differences in the levels of proglucagon-derived peptides in streptozotocin-induced diabetes.
Endocrinology 1989;124(6):3003-9.
1989: Daniel J Drucker; Patricia L Brubaker
Proglucagon gene expression is regulated by a cyclic AMP-dependent pathway in rat intestine.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(11):3953-7.
1988: J Philippe; A C Powers; S Mojsov; Daniel J Drucker; R Comi; Joel F Habener
Expression of peptide hormone genes in human islet cell tumors.
Diabetes 1988;37(12):1647-51.
1988: J Philippe; Daniel J Drucker; W Knepel; L Jepeal; Z Misulovin; Joel F Habener
Alpha-cell-specific expression of the glucagon gene is conferred to the glucagon promoter element by the interactions of DNA-binding proteins.
Molecular and cellular biology 1988;8(11):4877-88.
1988: Daniel J Drucker; J Philippe; S Mojsov
Proglucagon gene expression and posttranslational processing in a hamster islet cell line.
Endocrinology 1988;123(4):1861-7.
1988: Daniel J Drucker; Sylvia Asa
Glucagon gene expression in vertebrate brain.
The Journal of biological chemistry 1988;263(27):13475-8.
1987: Daniel J Drucker; J Philippe; L Jepeal; Joel F Habener
Glucagon gene 5'-flanking sequences promote islet cell-specific gene transcription.
The Journal of biological chemistry 1987;262(32):15659-65.
1987: Daniel J Drucker; J Philippe; S Mojsov; W L Chick; Joel F Habener
Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(10):3434-8.
1987: Daniel J Drucker; J Philippe; L Jepeal; Joel F Habener
cis-acting DNA sequence controls glucagon gene expression in pancreatic islet cells.
Transactions of the Association of American Physicians 1987;100():109-15.
1986: J Philippe; S Mojsov; Daniel J Drucker; Joel F Habener
Proglucagon processing in a rat islet cell line resembles phenotype of intestine rather than pancreas.
Endocrinology 1986;119(6):2833-9.
1986: Daniel J Drucker; S Mojsov; Joel F Habener
Cell-specific post-translational processing of preproglucagon expressed from a metallothionein-glucagon fusion gene.
The Journal of biological chemistry 1986;261(21):9637-43.