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Kirk Druey

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Chemicals & Drugs

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Amanda Hurley; Hiromi Imamichi; Tatiana Karpova; H Clifford Lane; James McNally; Erin Nickel; Beverly Packard; Stephen Shaw; Mindy Smith; Michael Sneller; Kirk M Druey; Dean Follmann; Rebecca B Hasley; Jeanette Higgins; Zonghui Hu; Nariman Balenga; Natalya Belkina; Marta Catalfamo
Enhanced effector function of CD8(+) T cells from healthy controls and HIV-infected patients occurs through thrombin activation of protease-activated receptor 1.
Sucharita P Shankar; Mark Wilson; Thomas A Wynn; Zhihui Xie; Jeffrey DiVietro; Margaret M Mentink-Kane; Kirk M Druey
RGS16 attenuates pulmonary Th2/Th17 inflammatory responses.
Zhao Yang; Richard Edwards; Reynold A Panettieri; Nariman Balenga; Christopher E Brightling; Philip R Cooper; Gautam Damera; Kirk M Druey
Regulator of G-protein signaling-5 inhibits bronchial smooth muscle contraction in severe asthma.

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All Publications

2013: Amanda Hurley; Hiromi Imamichi; Tatiana Karpova; H Clifford Lane; James McNally; Erin Nickel; Beverly Packard; Stephen Shaw; Mindy Smith; Michael Sneller; Kirk M Druey; Dean Follmann; Rebecca B Hasley; Jeanette Higgins; Zonghui Hu; Nariman Balenga; Natalya Belkina; Marta Catalfamo
Enhanced effector function of CD8(+) T cells from healthy controls and HIV-infected patients occurs through thrombin activation of protease-activated receptor 1.
The Journal of infectious diseases 2013;207(4):638-50.
2012: Sucharita P Shankar; Mark Wilson; Thomas A Wynn; Zhihui Xie; Jeffrey DiVietro; Margaret M Mentink-Kane; Kirk M Druey
RGS16 attenuates pulmonary Th2/Th17 inflammatory responses.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(12):6347-56.
2012: Zhao Yang; Richard Edwards; Reynold A Panettieri; Nariman Balenga; Christopher E Brightling; Philip R Cooper; Gautam Damera; Kirk M Druey
Regulator of G-protein signaling-5 inhibits bronchial smooth muscle contraction in severe asthma.
American journal of respiratory cell and molecular biology 2012;46(6):823-32.
2012: Zhihui Xie; Donna Gaskins; Chandra C Ghosh; Philip R Greipp; Shoko Iwaki; Nina Jones; Celeste Nelson; Samir M Parikh; Roshni Patel; Kirk M Druey
Vascular endothelial hyperpermeability induces the clinical symptoms of Clarkson disease (the systemic capillary leak syndrome).
Blood 2012;119(18):4321-32.
2012: Genqing Liang; Juan Rivera; Zhihui Xie; Tolga Barker; Nicolas Charles; Kirk M Druey
Naive T cells sense the cysteine protease allergen papain through protease-activated receptor 2 and propel TH2 immunity.
The Journal of allergy and clinical immunology 2012;129(5):1377-1386.e13.
2012: Peter Kellman; Sujata M Shanbhag; Martin Ugander; Joel R Wilson; Hui Xue; W Patricia Bandettini; Kirk M Druey; Andrew E Arai
Extracellular volume fraction mapping in the myocardium, part 2: initial clinical experience.
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 2012;14():64.
2012: Gautam Damera; Kirk M Druey; Toshinori Hoshi; Vera P Krymskaya; Yassine Amrani; Christopher E Brightling; Philip R Cooper; Roy J Soberman; Reynold A Panettieri
An RGS4-mediated phenotypic switch of bronchial smooth muscle cells promotes fixed airway obstruction in asthma.
PloS one 2012;7(1):e28504.
2011: Shoko Iwaki; Yunbiao Lu; Zhihui Xie; Kirk M Druey
p53 negatively regulates RGS13 protein expression in immune cells.
The Journal of biological chemistry 2011;286(25):22219-26.
2011: James Koh; Moahad Dar; Brian R Untch; Darshana Dixit; Yuhong Shi; Zhao Yang; Mohamed Abdelgadir Adam; Holly K Dressman; Xiaojuan Wang; Diane Gesty-Palmer; Jeffrey R Marks; Robert F Spurney; Kirk M Druey; John Olson
Regulator of G protein signaling 5 is highly expressed in parathyroid tumors and inhibits signaling by the calcium-sensing receptor.
Molecular endocrinology (Baltimore, Md.) 2011;25(5):867-76.
2011: Zhao Yang; Philip R Cooper; Gautam Damera; Indranil Mukhopadhyay; Hyeseon Cho; John H Kehrl; Reynold A Panettieri; Kirk M Druey
Beta-agonist-associated reduction in RGS5 expression promotes airway smooth muscle hyper-responsiveness.
The Journal of biological chemistry 2011;286(13):11444-55.
2010: Zhihui Xie; Zhao Yang; Kirk M Druey
Phosphorylation of RGS13 by the cyclic AMP-dependent protein kinase inhibits RGS13 degradation.
Journal of molecular cell biology 2010;2(6):357-65.
2010: Kirk M Druey; Philip R Greipp
Narrative review: the systemic capillary leak syndrome.
Annals of internal medicine 2010;153(2):90-8.
2010: Kimberly D Dyer; Caroline M Percopo; Zhihui Xie; Zhao Yang; John Dongil Kim; Francis Davoine; Paige Lacy; Kirk M Druey; Redwan Moqbel; Helene F Rosenberg
Mouse and human eosinophils degranulate in response to platelet-activating factor (PAF) and lysoPAF via a PAF-receptor-independent mechanism: evidence for a novel receptor.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(11):6327-34.
2009: Genqing Liang; Geetanjali Bansal; Zhihui Xie; Kirk M Druey
RGS16 inhibits breast cancer cell growth by mitigating phosphatidylinositol 3-kinase signaling.
The Journal of biological chemistry 2009;284(32):21719-27.
2009: Kirk M Druey
Regulation of G-protein-coupled signaling pathways in allergic inflammation.
Immunologic research 2009;43(1-3):62-76.
2008: Geetanjali Bansal; Jeffrey DiVietro; Hye Sun Kuehn; Sudhir Rao; Karl H Nocka; Alasdair M Gilfillan; Kirk M Druey
RGS13 controls g protein-coupled receptor-evoked responses of human mast cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(11):7882-90.
2008: Zhihui Xie; Timothy R Geiger; Eric N Johnson; Jennifer K Nyborg; Kirk M Druey
RGS13 acts as a nuclear repressor of CREB.
Molecular cell 2008;31(5):660-70.
2008: Geetanjali Bansal; Zhihui Xie; Sudhir Rao; Karl H Nocka; Kirk M Druey
Suppression of immunoglobulin E-mediated allergic responses by regulator of G protein signaling 13.
Nature immunology 2008;9(1):73-80.
2007: Geetanjali Bansal; Kirk M Druey; Zhihui Xie
R4 RGS proteins: regulation of G-protein signaling and beyond.
Pharmacology & therapeutics 2007;116(3):473-95.
2005: Maria Domenica Castellone; Hidemi Teramoto; Bart Williams; Kirk M Druey; J Silvio Gutkind
Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis.
Science (New York, N.Y.) 2005;310(5753):1504-10.
2004: Jacob D Estes; Tyler Thacker; Denise L Hampton; Sariah A Kell; Brandon F Keele; Emily A Palenske; Kirk M Druey; GREGORY BURTON
Follicular dendritic cell regulation of CXCR4-mediated germinal center CD4 T cell migration.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(10):6169-78.
2003: Eric N Johnson; Tammy M Seasholtz; Abdul A Waheed; Barry Kreutz; Nobuchika Suzuki; Tohru Kozasa; Teresa L Z Jones; Joan Heller Brown; Kirk M Druey
RGS16 inhibits signalling through the G alpha 13-Rho axis.
Nature cell biology 2003;5(12):1095-103.
2003: Kirk M Druey
Regulators of G protein signalling: potential targets for treatment of allergic inflammatory diseases such as asthma.
Expert opinion on therapeutic targets 2003;7(4):475-84.
2003: Eric Lippert; David L Yowe; Jose-Angel Gonzalo; J Paul Justice; Jeremy M Webster; Eric R Fedyk; Martin R Hodge; Cheryl Miller; Jose-Carlos Gutierrez-Ramos; Francisco Borrego; Andrea Keane-Myers; Kirk M Druey
Role of regulator of G protein signaling 16 in inflammation-induced T lymphocyte migration and activation.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(3):1542-55.
2003: Daljit S Bahia; Nana Sartania; Richard J Ward; Antonella Cavalli; Teresa L Z Jones; Kirk M Druey; Graeme Milligan
Concerted stimulation and deactivation of pertussis toxin-sensitive G proteins by chimeric G protein-coupled receptor-regulator of G protein signaling 4 fusion proteins: analysis of the contribution of palmitoylated cysteine residues to the GAP activity of RGS4.
Journal of neurochemistry 2003;85(5):1289-98.
2003: Abel Hiol; Penelope C Davey; James L Osterhout; Abdul A Waheed; Elizabeth R Fischer; Ching-Kang Chen; Graeme Milligan; Kirk M Druey; Teresa L Z Jones
Palmitoylation regulates regulators of G-protein signaling (RGS) 16 function. I. Mutation of amino-terminal cysteine residues on RGS16 prevents its targeting to lipid rafts and palmitoylation of an internal cysteine residue.
The Journal of biological chemistry 2003;278(21):19301-8.
2003: James L Osterhout; Abdul A Waheed; Abel Hiol; Richard J Ward; Penelope C Davey; Lylia Nini; Jiun Wang; Graeme Milligan; Teresa L Z Jones; Kirk M Druey
Palmitoylation regulates regulator of G-protein signaling (RGS) 16 function. II. Palmitoylation of a cysteine residue in the RGS box is critical for RGS16 GTPase accelerating activity and regulation of Gi-coupled signalling.
The Journal of biological chemistry 2003;278(21):19309-16.
2003: Alexandrine Derrien; Bin Zheng; James L Osterhout; Yong-Chao Ma; Graeme Milligan; Marilyn G Farquhar; Kirk M Druey
Src-mediated RGS16 tyrosine phosphorylation promotes RGS16 stability.
The Journal of biological chemistry 2003;278(18):16107-16.
2002: Jiaxin Niu; Astrid Scheschonka; Kirk M Druey; Amanda Davis; Eleanor Reed; Vladimir Kolenko; Richard J Bodnar; Tatyana Voyno-Yasenetskaya; Xiaoping Du; John Kehrl; Nickolai O Dulin
RGS3 interacts with 14-3-3 via the N-terminal region distinct from the RGS (regulator of G-protein signalling) domain.
The Biochemical journal 2002;365(Pt 3):677-84.
2002: Eric N Johnson; Kirk M Druey
Functional characterization of the G protein regulator RGS13.
The Journal of biological chemistry 2002;277(19):16768-74.
2002: Eric N Johnson; Kirk M Druey
Heterotrimeric G protein signaling: role in asthma and allergic inflammation.
The Journal of allergy and clinical immunology 2002;109(4):592-602.
2001: A Derrien; Kirk M Druey
RGS16 function is regulated by epidermal growth factor receptor-mediated tyrosine phosphorylation.
The Journal of biological chemistry 2001;276(51):48532-8.
2001: Kirk M Druey
Bridging with GAPs: receptor communication through RGS proteins.
Science's STKE : signal transduction knowledge environment 2001;2001(104):re14.
2000: BM Sullivan; K J Harrison-Lavoie; Vladimir Marshansky; Herbert Y Lin; John Kehrl; Dennis A Ausiello; Dennis Brown; Kirk M Druey
RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi membranes and intracellular transport.
Molecular biology of the cell 2000;11(9):3155-68.
2000: Antonella Cavalli; Kirk M Druey; Graeme Milligan
The regulator of G protein signaling RGS4 selectively enhances alpha 2A-adreoreceptor stimulation of the GTPase activity of Go1alpha and Gi2alpha.
The Journal of biological chemistry 2000;275(31):23693-9.
2000: Chantal Moratz; V H Kang; Kirk M Druey; Chong-Shan Shi; Astrid Scheschonka; P M Murphy; Tohru Kozasa; John Kehrl
Regulator of G protein signaling 1 (RGS1) markedly impairs Gi alpha signaling responses of B lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(4):1829-38.
1999: Kirk M Druey; Ozlem Ugur; J M Caron; Ching-Kang Chen; P S Backlund; Teresa L Z Jones
Amino-terminal cysteine residues of RGS16 are required for palmitoylation and modulation of Gi- and Gq-mediated signaling.
The Journal of biological chemistry 1999;274(26):18836-42.
1999: Carol Beadling; Kirk M Druey; G Richter; John Kehrl; Kendall A Smith
Regulators of G protein signaling exhibit distinct patterns of gene expression and target G protein specificity in human lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(5):2677-82.
1998: Edward P Bowman; James J Campbell; Kirk M Druey; Astrid Scheschonka; John Kehrl; Eugene C Butcher
Regulation of chemotactic and proadhesive responses to chemoattractant receptors by RGS (regulator of G-protein signaling) family members.
The Journal of biological chemistry 1998;273(43):28040-8.
1998: Kirk M Druey; BM Sullivan; Dennis Brown; E R Fischer; N Watson; K J Blumer; Charles R Gerfen; Astrid Scheschonka; John Kehrl
Expression of GTPase-deficient Gialpha2 results in translocation of cytoplasmic RGS4 to the plasma membrane.
The Journal of biological chemistry 1998;273(29):18405-10.
1997: Kirk M Druey; John Kehrl
Inhibition of regulator of G protein signaling function by two mutant RGS4 proteins.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(24):12851-6.
1997: Jimmy Neill; L Wayne Duck; Jeffrey C Sellers; Lois C Musgrove; Astrid Scheschonka; Kirk M Druey; John Kehrl
Potential role for a regulator of G protein signaling (RGS3) in gonadotropin-releasing hormone (GnRH) stimulated desensitization.
Endocrinology 1997;138(2):843-6.
1996: N Watson; Maurine E Linder; Kirk M Druey; John Kehrl; Kendall J Blumer
RGS family members: GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.
Nature 1996;383(6596):172-5.
1996: Joseph M Tuscano; Kirk M Druey; A Riva; J Pena; Craig Thompson; John Kehrl
Bcl-x rather than Bcl-2 mediates CD40-dependent centrocyte survival in the germinal center.
Blood 1996;88(4):1359-64.
1996: Kirk M Druey; Kendall J Blumer; V H Kang; John Kehrl
Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family.
Nature 1996;379(6567):742-6.
1994: K A Harrison; Kirk M Druey; Y Deguchi; Joseph M Tuscano; John Kehrl
A novel human homeobox gene distantly related to proboscipedia is expressed in lymphoid and pancreatic tissues.
The Journal of biological chemistry 1994;269(31):19968-75.