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Martin Drysdale

Research Profile

Chemicals & Drugs

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Drug Design

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Molecular Structure

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TOP 3
Nicholas G M Davies; Ben Davis; Martin J Drysdale; Nicolas Foloppe; Stephanie Geoffrey; Ben Gibbons; Terance Hart; Roderick Hubbard; Michael Rugaard Jensen; Howard Mansell; Andrew James Massey; Natalia Matassova; Jonathan D Moore; James Murray; Robert Pratt; Stuart Ray; Alan Robertson; Stephen D Roughley; Joseph Schoepfer; Kirsten Scriven; Heather Simmonite; Stephen Stokes; Allan Surgenor; Paul Webb; Mike Wood; Lisa Wright; Helen Browne; Paul A Brough
Targeting conserved water molecules: design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization.
Christine M Richardson; Claire L Nunns; Douglas Williamson; Martin J Parratt; Pawel Dokurno; Rob Howes; Jenifer Borgognoni; Martin J Drysdale; Harry Finch; Roderick E Hubbard; Philip S Jackson; Peter Kierstan; Georg Lentzen; Jonathan D Moore; James B Murray; Heather Simmonite; Allan Surgenor; Christopher J Torrance
Discovery of a potent CDK2 inhibitor with a novel binding mode, using virtual screening and initial, structure-guided lead scoping.
Swee Y Sharp; Chrisostomos Prodromou; Kathy Boxall; Marissa V Powers; Joanna L Holmes; Gary Box; Thomas P Matthews; Kwai-Ming J Cheung; Andrew Kalusa; Karen James; Angela Hayes; Anthea Hardcastle; Brian Dymock; Paul A Brough; Xavier Barril; Julie E Cansfield; Lisa Wright; Allan Surgenor; Nicolas Foloppe; Roderick E Hubbard; Wynne Aherne; Laurence H Pearl; Keith Jones; Edward McDonald; Florence I Raynaud; Suzanne A Eccles; Martin J Drysdale; Paul Workman
Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues.

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All Publications

2012: Nicholas G M Davies; Ben Davis; Martin J Drysdale; Nicolas Foloppe; Stephanie Geoffrey; Ben Gibbons; Terance Hart; Roderick Hubbard; Michael Rugaard Jensen; Howard Mansell; Andrew James Massey; Natalia Matassova; Jonathan D Moore; James Murray; Robert Pratt; Stuart Ray; Alan Robertson; Stephen D Roughley; Joseph Schoepfer; Kirsten Scriven; Heather Simmonite; Stephen Stokes; Allan Surgenor; Paul Webb; Mike Wood; Lisa Wright; Helen Browne; Paul A Brough
Targeting conserved water molecules: design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization.
Bioorganic & medicinal chemistry 2012;20(22):6770-89.
2007: Christine M Richardson; Claire L Nunns; Douglas Williamson; Martin J Parratt; Pawel Dokurno; Rob Howes; Jenifer Borgognoni; Martin J Drysdale; Harry Finch; Roderick E Hubbard; Philip S Jackson; Peter Kierstan; Georg Lentzen; Jonathan D Moore; James B Murray; Heather Simmonite; Allan Surgenor; Christopher J Torrance
Discovery of a potent CDK2 inhibitor with a novel binding mode, using virtual screening and initial, structure-guided lead scoping.
Bioorganic & medicinal chemistry letters 2007;17(14):3880-5.
2007: Swee Y Sharp; Chrisostomos Prodromou; Kathy Boxall; Marissa V Powers; Joanna L Holmes; Gary Box; Thomas P Matthews; Kwai-Ming J Cheung; Andrew Kalusa; Karen James; Angela Hayes; Anthea Hardcastle; Brian Dymock; Paul A Brough; Xavier Barril; Julie E Cansfield; Lisa Wright; Allan Surgenor; Nicolas Foloppe; Roderick E Hubbard; Wynne Aherne; Laurence H Pearl; Keith Jones; Edward McDonald; Florence I Raynaud; Suzanne A Eccles; Martin J Drysdale; Paul Workman
Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues.
Molecular cancer therapeutics 2007;6(4):1198-211.
2007: Roderick E Hubbard; Ben Davis; Ijen Chen; Martin J Drysdale
The SeeDs approach: integrating fragments into drug discovery.
Current topics in medicinal chemistry 2007;7(16):1568-81.
2006: Martin J Drysdale; Paul A Brough; Andrew James Massey; Michael Rugaard Jensen; Joseph Schoepfer
Targeting Hsp90 for the treatment of cancer.
Current opinion in drug discovery & development 2006;9(4):483-95.
2006: Nicola F Smith; Angela Hayes; Karen James; Bernard P Nutley; Edward McDonald; Alan Henley; Brian Dymock; Martin J Drysdale; Florence I Raynaud; Paul Workman
Preclinical pharmacokinetics and metabolism of a novel diaryl pyrazole resorcinol series of heat shock protein 90 inhibitors.
Molecular cancer therapeutics 2006;5(6):1628-37.
2006: Xavier Barril; Mandy Beswick; Adam Collier; Martin J Drysdale; Brian Dymock; Alexandra Fink; Kate Grant; Rob Howes; Allan M Jordan; Andrew James Massey; Allan Surgenor; Joanne Wayne; Paul Workman; Lisa Wright
4-Amino derivatives of the Hsp90 inhibitor CCT018159.
Bioorganic & medicinal chemistry letters 2006;16(9):2543-8.
2006: Rob Howes; Xavier Barril; Brian Dymock; Kate Grant; C J Northfield; Alan G S Robertson; Allan Surgenor; J Wayne; Lisa Wright; Karen James; T Matthews; Kwai-Ming J Cheung; Edward McDonald; Paul Workman; Martin J Drysdale
A fluorescence polarization assay for inhibitors of Hsp90.
Analytical biochemistry 2006;350(2):202-13.
2006: Edward McDonald; Keith Jones; Paul A Brough; Martin J Drysdale; Paul Workman
Discovery and development of pyrazole-scaffold Hsp90 inhibitors.
Current topics in medicinal chemistry 2006;6(11):1193-203.
2005: Paul A Brough; Xavier Barril; Mandy Beswick; Brian Dymock; Martin J Drysdale; Lisa Wright; Kate Grant; Andrew James Massey; Allan Surgenor; Paul Workman
3-(5-Chloro-2,4-dihydroxyphenyl)-pyrazole-4-carboxamides as inhibitors of the Hsp90 molecular chaperone.
Bioorganic & medicinal chemistry letters 2005;15(23):5197-201.
2005: Xavier Barril; Paul A Brough; Martin J Drysdale; Roderick E Hubbard; Andrew James Massey; Allan Surgenor; Lisa Wright
Structure-based discovery of a new class of Hsp90 inhibitors.
Bioorganic & medicinal chemistry letters 2005;15(23):5187-91.
2005: Brian Dymock; Xavier Barril; Paul A Brough; Julie E Cansfield; Andrew James Massey; Edward McDonald; Roderick E Hubbard; Allan Surgenor; Stephen D Roughley; Paul Webb; Paul Workman; Lisa Wright; Martin J Drysdale
Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design.
Journal of medicinal chemistry 2005;48(13):4212-5.
2004: Nicolas Baurin; Fareed Aboul-Ela; Xavier Barril; Ben Davis; Martin J Drysdale; Brian Dymock; Harry Finch; Christophe Fromont; Christine Richardson; Heather Simmonite; Roderick E Hubbard
Design and characterization of libraries of molecular fragments for use in NMR screening against protein targets.
Journal of chemical information and computer sciences 2004;44(6):2157-66.
2004: Lisa Wright; Xavier Barril; Brian Dymock; Louisa Sheridan; Allan Surgenor; Mandy Beswick; Martin J Drysdale; Adam Collier; Andrew James Massey; Nick Davies; Alexandra Fink; Christophe Fromont; Wynne Aherne; Kathy Boxall; Swee Sharp; Paul Workman; Roderick E Hubbard
Structure-activity relationships in purine-based inhibitor binding to HSP90 isoforms.
Chemistry & biology 2004;11(6):775-85.
2004: Alastair I H Murchie; Ben Davis; Catherine Isel; Mohammad Afshar; Martin J Drysdale; Justin Bower; Andrew J Potter; Ian D Starkey; Terry M Swarbrick; Shabana Mirza; Catherine D Prescott; Philippe Vaglio; Fareed Aboul-Ela; Jonathan Karn
Structure-based drug design targeting an inactive RNA conformation: exploiting the flexibility of HIV-1 TAR RNA.
Journal of molecular biology 2004;336(3):625-38.
2004: Ben Davis; Mohammad Afshar; Gabriele Varani; Alastair I H Murchie; Jonathan Karn; Georg Lentzen; Martin J Drysdale; Justin Bower; Andrew J Potter; Ian D Starkey; Terry Swarbrick; Fareed Aboul-Ela
Rational design of inhibitors of HIV-1 TAR RNA through the stabilisation of electrostatic "hot spots".
Journal of molecular biology 2004;336(2):343-56.
2004: Brian Dymock; Xavier Barril; Mandy Beswick; Adam Collier; Nicholas Davies; Martin J Drysdale; Alexandra Fink; Christophe Fromont; Roderick E Hubbard; Andrew James Massey; Allan Surgenor; Lisa Wright
Adenine derived inhibitors of the molecular chaperone HSP90-SAR explained through multiple X-ray structures.
Bioorganic & medicinal chemistry letters 2004;14(2):325-8.
2003: Justin Bower; Martin J Drysdale; Richard Hebdon; Allan Jordan; Georg Lentzen; Natalia Matassova; Alastair I H Murchie; Jenifer Powles; Stephen D Roughley
Structure-based design of agents targeting the bacterial ribosome.
Bioorganic & medicinal chemistry letters 2003;13(15):2455-8.
2002: Martin J Drysdale; Georg Lentzen; Natalia Matassova; Alastair I H Murchie; Fareed Aboul-Ela; Mohammad Afshar
RNA as a drug target.
Progress in medicinal chemistry 2002;39():73-119.