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Cyril D'Souza

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Irina Esterlis; Jonas O Hannestad; Dorothy M Hatsukami; Frederic Bois; Kelly P Cosgrove; D Cyril D'Souza; Evgenia Perkins; John P Seibyl; Rachel F Tyndale; Stephanie S O'Malley
Effect of a nicotine vaccine on nicotine binding to β2*-nicotinic acetylcholine receptors in vivo in human tobacco smokers.
R Andrew Sewell; Patrick D Skosnik; Ashley Williams; Jacqueline Elander; Brian Pittman; Rajiv Radhakrishnan; Mohini Ranganathan; Ashley Schnakenberg; D Cyril D'Souza
Acute effects of THC on time perception in frequent and infrequent cannabis users.
Handan Gunduz-Bruce; Styliani Kaliora; Stephen Oliver; D Cyril D'Souza; Kimberlee Forselius-Bielen; Ralitza Gueorguieva; Susan Ray; Cenk Tek; Zoran Zimolo; Georgios Petrides
Efficacy of pimozide augmentation for clozapine partial responders with schizophrenia.

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2013: Irina Esterlis; Jonas O Hannestad; Dorothy M Hatsukami; Frederic Bois; Kelly P Cosgrove; D Cyril D'Souza; Evgenia Perkins; John P Seibyl; Rachel F Tyndale; Stephanie S O'Malley
Effect of a nicotine vaccine on nicotine binding to β2*-nicotinic acetylcholine receptors in vivo in human tobacco smokers.
The American journal of psychiatry 2013;170(4):399-407.
2013: R Andrew Sewell; Patrick D Skosnik; Ashley Williams; Jacqueline Elander; Brian Pittman; Rajiv Radhakrishnan; Mohini Ranganathan; Ashley Schnakenberg; D Cyril D'Souza
Acute effects of THC on time perception in frequent and infrequent cannabis users.
Psychopharmacology 2013;226(2):401-13.
2013: Handan Gunduz-Bruce; Styliani Kaliora; Stephen Oliver; D Cyril D'Souza; Kimberlee Forselius-Bielen; Ralitza Gueorguieva; Susan Ray; Cenk Tek; Zoran Zimolo; Georgios Petrides
Efficacy of pimozide augmentation for clozapine partial responders with schizophrenia.
Schizophrenia research 2013;143(2-3):344-7.
2013: D Cyril D'Souza; Edward Perry; Brian Pittman; Rajiv Radhakrishnan; Mahendra P Sharma; Nagendra M Singh; Richa Yadav; D Abi-Saab; Morris Bell; Savita Bhakta; Santosh K Chaturvedi; Chittaranjan Andrade
Feasibility, safety, and efficacy of the combination of D-serine and computerized cognitive retraining in schizophrenia: an international collaborative pilot study.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2013;38(3):492-503.
2012: Mohini Ranganathan; Ashley Schnakenberg; R Andrew Sewell; Patrick D Skosnik; Bruce M Cohen; Brian Pittman; D Cyril D'Souza
Dose-related behavioral, subjective, endocrine, and psychophysiological effects of the κ opioid agonist Salvinorin A in humans.
Biological psychiatry 2012;72(10):871-9.
2012: D Cyril D'Souza; Jacqueline Elander; Peter Jatlow; Haleh Nadim; Brian Pittman; Kyungheup Ahn; Savita Bhakta; Nagendra Singh; Raymond F Suckow; Mohini Ranganathan
Nicotine fails to attenuate ketamine-induced cognitive deficits and negative and positive symptoms in humans: implications for schizophrenia.
Biological psychiatry 2012;72(9):785-94.
2012: Mohini Ranganathan; Richard A Sewell; Gabriel Braley; Michelle Carbuto; Jaqueline Elander; Edward Perry; Brian Pittman; Rajiv Radhakrishnan; D Cyril D'Souza
Naltrexone does not attenuate the effects of intravenous Δ9-tetrahydrocannabinol in healthy humans.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2012;15(9):1251-64.
2012: Patrick D Skosnik; Adam B Steinmetz; Jennifer M Vollmer; D Cyril D'Souza; Chad R Edwards; William P Hetrick; Brian F O'Donnell
The effect of chronic cannabinoids on broadband EEG neural oscillations in humans.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2012;37(10):2184-93.
2012: Richard S E Keefe; Stephen M Marder; Alice Medalia; Stephen J Olson; Jayendra K Patel; Peter F Buckley; Stanley N Caroff; D Cyril D'Souza; Karen A Graham; Adam J Haim; Robert M Hamer; Philip D Harvey; Dawn I Velligan; Sophia Vinogradov; Trina M Walker; Del D Miller; Thomas Stroup
Feasibility and pilot efficacy results from the multisite Cognitive Remediation in the Schizophrenia Trials Network (CRSTN) randomized controlled trial.
The Journal of clinical psychiatry 2012;73(7):1016-22.
2012: D Cyril D'Souza; Jacqueline Elander; Daniel J Fridberg; Michelle Carbuto; Brian Pittman; Mohini Ranganathan; Brian Roach; Ashley Schnakenberg; R Andrew Sewell; Nagendra Singh; Patrick D Skosnik; Ashley Williams; Daniel H Mathalon
Dose-related modulation of event-related potentials to novel and target stimuli by intravenous Δ⁹-THC in humans.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2012;37(7):1632-46.
2012: Handan Gunduz-Bruce; John H Krystal; D Cyril D'Souza; Judith M Ford; Ralitza Gueorguieva; Stephen Oliver; Robert M G Reinhart; Brian J Roach; Daniel H Mathalon
Glutamatergic modulation of auditory information processing in the human brain.
Biological psychiatry 2012;71(11):969-77.
2012: Elizabeth Ralevski; Michael Vendetti; Vanessa Bufis; Thomas B Cooper; Erica Dean; D Cyril D'Souza; Jacqueline Elander; Diana Limoncelli; Sherry McKee; Edward B Perry; Ismene Petrakis
Preliminary findings on the interactive effects of IV ethanol and IV nicotine on human behavior and cognition: a laboratory study.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2012;14(5):596-606.
2012: Patrick D Skosnik; Mohini Ranganathan; D Cyril D'Souza
Cannabinoids, working memory, and schizophrenia.
Biological psychiatry 2012;71(8):662-3.
2012: D Cyril D'Souza; Jacqueline Elander; Pierre Peeters; Brian Pittman; Mohini Ranganathan; Michelle Carbuto; Joanna Udo de Haes; Nagendra Singh; Magnus Sjogren; Jacques Schipper
Glycine transporter inhibitor attenuates the psychotomimetic effects of ketamine in healthy males: preliminary evidence.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2012;37(4):1036-46.
2012: Michelle Carbuto; D Cyril D'Souza; Jacqueline Elander; Kim Forselius-Bielen; Edward Perry; Brian Pittman; Mohini Ranganathan; Ashley Schnakenberg; R Andrew Sewell; Ashley Williams; Savita Bhakta; Gabriel Braley
The safety of studies with intravenous Δ⁹-tetrahydrocannabinol in humans, with case histories.
Psychopharmacology 2012;219(3):885-96.
2011: John H Krystal; Ismene L Petrakis; Diana Limoncelli; Susan Krasnicki Nappi; Louis Trevisan; Brian Pittman; D Cyril D'Souza; Raymond F Suckow
Characterization of the interactive effects of glycine and D-cycloserine in men: further evidence for enhanced NMDA receptor function associated with human alcohol dependence.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2011;36(3):701-10.
2010: R Andrew Sewell; Edward B Perry; Laurence P Karper; Morris D Bell; Paul H Lysaker; Joseph L Goulet; Louise Brenner; Joseph Erdos; D Cyril D'Souza; John P Seibyl; John H Krystal
Clinical significance of neurological soft signs in schizophrenia: factor analysis of the Neurological Evaluation Scale.
Schizophrenia research 2010;124(1-3):1-12.
2010: John H Krystal; Sanjay J Mathew; D Cyril D'Souza; Amir Garakani; Handan Gunduz-Bruce; Dennis S Charney
Potential psychiatric applications of metabotropic glutamate receptor agonists and antagonists.
CNS drugs 2010;24(8):669-93.
2010: Philip R Corlett; D Cyril D'Souza; John H Krystal
Capgras syndrome induced by ketamine in a healthy subject.
Biological psychiatry 2010;68(1):e1-2.
2009: John H Krystal; David F Tolin; Gerard Sanacora; Stacy A Castner; Graham V Williams; Deane E Aikins; Ralph E Hoffman; D Cyril D'Souza
Neuroplasticity as a target for the pharmacotherapy of anxiety disorders, mood disorders, and schizophrenia.
Drug discovery today 2009;14(13-14):690-7.
2009: Mohini Ranganathan; Gabriel Braley; Brian Pittman; Thomas Cooper; Edward Perry; John H Krystal; D Cyril D'Souza
The effects of cannabinoids on serum cortisol and prolactin in humans.
Psychopharmacology 2009;203(4):737-44.
2009: D Cyril D'Souza; Brian Pittman; Edward Perry; Arthur Simen
Preliminary evidence of cannabinoid effects on brain-derived neurotrophic factor (BDNF) levels in humans.
Psychopharmacology 2009;202(4):569-78.
2008: D Cyril D'Souza; Mohini Ranganathan; Gabriel Braley; Ralitza Gueorguieva; Zoran Zimolo; Thomas Cooper; Edward Perry; John H Krystal
Blunted psychotomimetic and amnestic effects of delta-9-tetrahydrocannabinol in frequent users of cannabis.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2008;33(10):2505-16.
2008: D Cyril D'Souza; Gabriel Braley; Rebecca Blaise; Michael Vendetti; Stephen Oliver; Brian Pittman; Mohini Ranganathan; Savita Bhakta; Zoran Zimolo; Thomas Cooper; Edward Perry
Effects of haloperidol on the behavioral, subjective, cognitive, motor, and neuroendocrine effects of Delta-9-tetrahydrocannabinol in humans.
Psychopharmacology 2008;198(4):587-603.
2008: Louis Trevisan; Ismene L Petrakis; Brian Pittman; Ralitza Gueorguieva; D Cyril D'Souza; Edward Perry; Diana Limoncelli; John H Krystal
Absence of significant interactive effects of high-dose D-cycloserine and ethanol in healthy human subjects: preliminary insights into ethanol actions at the glycine B site of NMDA glutamate receptors.
Alcoholism, clinical and experimental research 2008;32(1):36-42.
2007: Edward B Perry; Joyce A Cramer; Hyun-Sang Cho; Ismene L Petrakis; Laurence P Karper; Angelina Genovese; Elizabeth O'Donnell; John H Krystal; D Cyril D'Souza
Psychiatric safety of ketamine in psychopharmacology research.
Psychopharmacology 2007;192(2):253-60.
2007: D Cyril D'Souza
Cannabinoids and psychosis.
International review of neurobiology 2007;78():289-326.
2006: John H Krystal; D Cyril D'Souza; Jürgen Gallinat; Naomi Driesen; Anissa Abi-Dargham; Ismene L Petrakis; Andreas Heinz; Godfrey D Pearlson
The vulnerability to alcohol and substance abuse in individuals diagnosed with schizophrenia.
Neurotoxicity research 2006;10(3-4):235-52.
2006: D Cyril D'Souza; Roberto B Gil; Steven Madonick; Edward B Perry; Kimberlee Forselius-Bielen; Gabriel Braley; Lia Donahue; Tahir Tellioglu; Zoran Zimolo; Ralitza Gueorguieva; John H Krystal
Enhanced sensitivity to the euphoric effects of alcohol in schizophrenia.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2006;31(12):2767-75.
2006: Mohini Ranganathan; D Cyril D'Souza
The acute effects of cannabinoids on memory in humans: a review.
Psychopharmacology 2006;188(4):425-44.
2006: Celia J A Morgan; Edward B Perry; Hyun-Sang Cho; John H Krystal; D Cyril D'Souza
Greater vulnerability to the amnestic effects of ketamine in males.
Psychopharmacology 2006;187(4):405-14.
2006: John H Krystal; Steven Madonick; Edward Perry; Ralitza Gueorguieva; Laura Brush; Yola Wray; Aysenil Belger; D Cyril D'Souza
Potentiation of low dose ketamine effects by naltrexone: potential implications for the pharmacotherapy of alcoholism.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2006;31(8):1793-800.
2006: Vinod H Srihari; Tih-Shih Warren Lee; Robert M Rohrbaugh; D Cyril D'Souza
Revisiting cycloid psychosis: a case of an acute, transient and recurring psychotic disorder.
Schizophrenia research 2006;82(2-3):261-4.
2006: D Cyril D'Souza; Roberto B Gil; Edward Zuzarte; Lisa MacDougall; Lia Donahue; John S Ebersole; Nashaat N Boutros; Tom Cooper; John P Seibyl; John H Krystal
gamma-Aminobutyric acid-serotonin interactions in healthy men: implications for network models of psychosis and dissociation.
Biological psychiatry 2006;59(2):128-37.
2005: John H Krystal; Edward B Perry; Ralitza Gueorguieva; Aysenil Belger; Steven Madonick; Anissa Abi-Dargham; Thomas B Cooper; Lisa MacDougall; Walid Abi-Saab; D Cyril D'Souza
Comparative and interactive human psychopharmacologic effects of ketamine and amphetamine: implications for glutamatergic and dopaminergic model psychoses and cognitive function.
Archives of general psychiatry 2005;62(9):985-94.
2005: Hyun-Sang Cho; D Cyril D'Souza; Ralitza Gueorguieva; Edward B Perry; Steven Madonick; Laurence P Karper; Anissa Abi-Dargham; Aysenil Belger; Walid Abi-Saab; Deborah S Lipschitz; Alexandre Bennet; John P Seibyl; John H Krystal
Absence of behavioral sensitization in healthy human subjects following repeated exposure to ketamine.
Psychopharmacology 2005;179(1):136-43.
2005: John H Krystal; Walid Abi-Saab; Edward Perry; D Cyril D'Souza; Nianjun Liu; Ralitza Gueorguieva; Lisa McDougall; Tracy Hunsberger; Aysenil Belger; Louise Levine; Alan Breier
Preliminary evidence of attenuation of the disruptive effects of the NMDA glutamate receptor antagonist, ketamine, on working memory by pretreatment with the group II metabotropic glutamate receptor agonist, LY354740, in healthy human subjects.
Psychopharmacology 2005;179(1):303-9.
2005: D Cyril D'Souza; Walid Abi-Saab; Steven Madonick; Kimberlee Forselius-Bielen; Anne Doersch; Gabriel Braley; Ralitza Gueorguieva; Thomas B Cooper; John H Krystal
Delta-9-tetrahydrocannabinol effects in schizophrenia: implications for cognition, psychosis, and addiction.
Biological psychiatry 2005;57(6):594-608.
2004: D Cyril D'Souza; Edward Perry; Lisa MacDougall; Yola Ammerman; Thomas Cooper; Yu-Te Wu; Gabriel Braley; Ralitza Gueorguieva; John H Krystal
The psychotomimetic effects of intravenous delta-9-tetrahydrocannabinol in healthy individuals: implications for psychosis.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2004;29(8):1558-72.
2004: Leslie K Jacobsen; D Cyril D'Souza; W Einar Mencl; Kenneth R Pugh; Pawel Skudlarski; John H Krystal
Nicotine effects on brain function and functional connectivity in schizophrenia.
Biological psychiatry 2004;55(8):850-8.
2003: John H Krystal; Ismene L Petrakis; Evgeny Krupitsky; Christian Schutz; Louis Trevisan; D Cyril D'Souza
NMDA receptor antagonism and the ethanol intoxication signal: from alcoholism risk to pharmacotherapy.
Annals of the New York Academy of Sciences 2003;1003():176-84.
2003: John H Krystal; Ismene L Petrakis; Diana Limoncelli; Elizabeth Webb; Ralitza Gueorgueva; D Cyril D'Souza; Nashaat N Boutros; Louis Trevisan; Dennis S Charney
Altered NMDA glutamate receptor antagonist response in recovering ethanol-dependent patients.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(11):2020-8.
2003: John H Krystal; D Cyril D'Souza; Daniel Mathalon; Edward Perry; Aysenil Belger; Ralph Hoffman
NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development.
Psychopharmacology 2003;169(3-4):215-33.
2003: John H Krystal; Ismene L Petrakis; Graeme Mason; Louis Trevisan; D Cyril D'Souza
N-methyl-D-aspartate glutamate receptors and alcoholism: reward, dependence, treatment, and vulnerability.
Pharmacology & therapeutics 2003;99(1):79-94.
2002: Walid Abi-Saab; John P Seibyl; D Cyril D'Souza; Laurence P Karper; Ralitza Gueorgueva; Anissa Abi-Dargham; Ma-Li Wong; Sachin Rajhans; Joseph Erdos; George R Heninger; Dennis S Charney; John H Krystal
Ritanserin antagonism of m-chlorophenylpiperazine effects in neuroleptic-free schizophrenics patients: support for serotonin-2 receptor modulation of schizophrenia symptoms.
Psychopharmacology 2002;162(1):55-62.
2001: John H Krystal; D Cyril D'Souza; Gerard Sanacora; Andrew W Goddard; Dennis S Charney
Current perspectives on the pathophysiology of schizophrenia, depression, and anxiety disorders.
The Medical clinics of North America 2001;85(3):559-77.
2000: D Cyril D'Souza; R Gil; K Cassello; K Morrissey; D Abi-Saab; J White; R Sturwold; A Bennett; Laurence P Karper; E Zuzarte; Dennis S Charney; John H Krystal
IV glycine and oral D-cycloserine effects on plasma and CSF amino acids in healthy humans.
Biological psychiatry 2000;47(5):450-62.
2000: Marc Laruelle; Anissa Abi-Dargham; Christopher H van Dyck; Roberto Gil; D Cyril D'Souza; John Krystal; John P Seibyl; R Baldwin; Robert B Innis
Dopamine and serotonin transporters in patients with schizophrenia: an imaging study with [(123)I]beta-CIT.
Biological psychiatry 2000;47(5):371-9.
2000: John H Krystal; A Bennett; D Abi-Saab; Aysenil Belger; Laurence P Karper; D Cyril D'Souza; Deborah S Lipschitz; Anissa Abi-Dargham; Dennis S Charney
Dissociation of ketamine effects on rule acquisition and rule implementation: possible relevance to NMDA receptor contributions to executive cognitive functions.
Biological psychiatry 2000;47(2):137-43.
1999: D Cyril D'Souza; Robert M Berman; John H Krystal; D S Charney
Symptom provocation studies in psychiatric disorders: scientific value, risks, and future.
Biological psychiatry 1999;46(8):1060-80.
1999: John H Krystal; D Cyril D'Souza; Ismene L Petrakis; Aysenil Belger; Robert M Berman; Dennis S Charney; Walid Abi-Saab; Steven Madonick
NMDA agonists and antagonists as probes of glutamatergic dysfunction and pharmacotherapies in neuropsychiatric disorders.
Harvard review of psychiatry 1999;7(3):125-43.
1999: John H Krystal; D Cyril D'Souza; Laurence P Karper; A Bennett; Anissa Abi-Dargham; D Abi-Saab; K Cassello; Malcolm B Bowers; Sally Vegso; George R Heninger; Dennis S Charney
Interactive effects of subanesthetic ketamine and haloperidol in healthy humans.
Psychopharmacology 1999;145(2):193-204.
1999: John H Krystal; D Cyril D'Souza; Steven Madonick; Ismene L Petrakis
Toward a rational pharmacotherapy of comorbid substance abuse in schizophrenic patients.
Schizophrenia research 1999;35 Suppl():S35-49.
1998: Walid Abi-Saab; D Cyril D'Souza; Bita Moghaddam; John H Krystal
The NMDA antagonist model for schizophrenia: promise and pitfalls.
Pharmacopsychiatry 1998;31 Suppl 2():104-9.
1998: John H Krystal; Laurence P Karper; A Bennett; D Cyril D'Souza; Anissa Abi-Dargham; K Morrissey; D Abi-Saab; J Douglas Bremner; Malcolm B Bowers; Raymond F Suckow; P Stetson; George R Heninger; Dennis S Charney
Interactive effects of subanesthetic ketamine and subhypnotic lorazepam in humans.
Psychopharmacology 1998;135(3):213-29.
1994: D Cyril D'Souza; A Bennett; Anissa Abi-Dargham; John H Krystal
Precipitation of a psychoneuromotor syndrome by fluoxetine in a haloperidol-treated schizophrenic patient.
Journal of clinical psychopharmacology 1994;14(5):361-3.